| Year |
Citation |
Score |
| 2024 |
Williams AS, Crown SB, Lyons SP, Koves TR, Wilson RJ, Johnson JM, Slentz DH, Kelly DP, Grimsrud PA, Zhang GF, Muoio DM. Ketone flux through BDH1 supports metabolic remodeling of skeletal and cardiac muscles in response to intermittent time-restricted feeding. Cell Metabolism. 36: 422-437.e8. PMID 38325337 DOI: 10.1016/j.cmet.2024.01.007 |
0.372 |
|
| 2023 |
Guilherme A, Rowland LA, Wetoska N, Tsagkaraki E, Santos KB, Bedard AH, Henriques F, Kelly M, Munroe S, Pedersen DJ, Ilkayeva OR, Koves TR, Tauer L, Pan M, Han X, ... ... Muoio DM, et al. Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program. Cell Reports. 42: 112488. PMID 37163372 DOI: 10.1016/j.celrep.2023.112488 |
0.333 |
|
| 2023 |
Koves TR, Zhang GF, Davidson MT, Chaves AB, Crown SB, Johnson JM, Slentz DH, Grimsrud PA, Muoio DM. Pyruvate-supported flux through medium-chain ketothiolase promotes mitochondrial lipid tolerance in cardiac and skeletal muscles. Cell Metabolism. PMID 37060901 DOI: 10.1016/j.cmet.2023.03.016 |
0.387 |
|
| 2023 |
Yamamoto T, Maurya SK, Pruzinsky E, Batmanov K, Xiao Y, Sulon SM, Sakamoto T, Wang Y, Lai L, McDaid KS, Shewale SV, Leone TC, Koves TR, Muoio DM, Dierickx P, et al. RIP140 deficiency enhances cardiac fuel metabolism and protects mice from heart failure. The Journal of Clinical Investigation. PMID 36927960 DOI: 10.1172/JCI162309 |
0.3 |
|
| 2021 |
Williams AS, Koves TR, Pettway YD, Draper JA, Slentz DH, Grimsrud PA, Ilkayeva OR, Muoio DM. Nicotinamide riboside supplementation confers marginal metabolic benefits in obese mice without remodeling the muscle acetyl-proteome. Iscience. 25: 103635. PMID 35028529 DOI: 10.1016/j.isci.2021.103635 |
0.39 |
|
| 2020 |
White PJ, Lapworth AL, McGarrah RW, Kwee LC, Crown SB, Ilkayeva O, An J, Carson MW, Christopher BA, Ball JR, Davies MN, Kjalarsdottir L, George T, Muehlbauer MJ, Bain JR, ... ... Muoio DM, et al. Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion. Cell Reports. 33: 108375. PMID 33176135 DOI: 10.1016/j.celrep.2020.108375 |
0.414 |
|
| 2020 |
Davidson MT, Grimsrud P, Lai L, Draper J, Fisher-Wellman KH, Narowski TM, Koves TR, Kelly DP, Muoio DM. Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure. Circulation Research. PMID 32660330 DOI: 10.1161/Circresaha.120.317293 |
0.361 |
|
| 2020 |
Bartlett DB, Slentz CA, Willis LH, Hoselton A, Huebner JL, Kraus VB, Moss J, Muehlbauer MJ, Spielmann G, Muoio DM, Koves TR, Wu H, Huffman KM, Lord JM, Kraus WE. Rejuvenation of Neutrophil Functions in Association With Reduced Diabetes Risk Following Ten Weeks of Low-Volume High Intensity Interval Walking in Older Adults With Prediabetes - A Pilot Study. Frontiers in Immunology. 11: 729. PMID 32431698 DOI: 10.3389/Fimmu.2020.00729 |
0.321 |
|
| 2020 |
Yurdagul A, Subramanian M, Wang X, Crown SB, Ilkayeva OR, Darville L, Kolluru GK, Rymond CC, Gerlach BD, Zheng Z, Kuriakose G, Kevil CG, Koomen JM, Cleveland JL, Muoio DM, et al. Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury. Cell Metabolism. PMID 32004476 DOI: 10.1016/J.Cmet.2020.01.001 |
0.32 |
|
| 2019 |
Williams AS, Koves TR, Davidson MT, Crown SB, Fisher-Wellman KH, Torres MJ, Draper JA, Narowski TM, Slentz DH, Lantier L, Wasserman DH, Grimsrud PA, Muoio DM. Disruption of Acetyl-Lysine Turnover in Muscle Mitochondria Promotes Insulin Resistance and Redox Stress without Overt Respiratory Dysfunction. Cell Metabolism. PMID 31813822 DOI: 10.1016/J.Cmet.2019.11.003 |
0.462 |
|
| 2019 |
Bruls YM, de Ligt M, Lindeboom L, Phielix E, Havekes B, Schaart G, Kornips E, Wildberger JE, Hesselink MK, Muoio D, Schrauwen P, Schrauwen-Hinderling VB. Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trial. Ebiomedicine. 49: 318-330. PMID 31676389 DOI: 10.1016/J.Ebiom.2019.10.017 |
0.422 |
|
| 2019 |
Ho KL, Zhang L, Wagg C, Batran RA, Gopal K, Levasseur J, Leone T, Dyck JRB, Ussher JR, Muoio DM, Kelly DP, Lopaschuk GD. Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency. Cardiovascular Research. PMID 30778524 DOI: 10.1093/Cvr/Cvz045 |
0.308 |
|
| 2019 |
Lin KH, Xie A, Rutter JC, Ahn YR, Lloyd-Cowden JM, Nichols AG, Soderquist RS, Koves TR, Muoio DM, MacIver NJ, Lamba JK, Pardee TS, McCall CM, Rizzieri DA, Wood KC. Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity. Cell Metabolism. PMID 30773463 DOI: 10.1016/J.Cmet.2019.01.011 |
0.342 |
|
| 2019 |
Fisher-Wellman KH, Draper JA, Davidson MT, Williams AS, Narowski TM, Slentz DH, Ilkayeva OR, Stevens RD, Wagner GR, Najjar R, Hirschey MD, Thompson JW, Olson DP, Kelly DP, Koves TR, ... ... Muoio DM, et al. Respiratory Phenomics across Multiple Models of Protein Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on Bioenergetics. Cell Reports. 26: 1557-1572.e8. PMID 30726738 DOI: 10.1016/J.Celrep.2019.01.057 |
0.332 |
|
| 2019 |
Horton JL, Davidson MT, Kurishima C, Vega RB, Powers JC, Matsuura TR, Petucci C, Lewandowski ED, Crawford PA, Muoio DM, Recchia FA, Kelly DP. The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense. Jci Insight. PMID 30668551 DOI: 10.1172/Jci.Insight.124079 |
0.332 |
|
| 2018 |
Fisher-Wellman KH, Davidson MT, Narowski TM, Lin CT, Koves TR, Muoio DM. Mitochondrial Diagnostics: A Multiplexed Assay Platform for Comprehensive Assessment of Mitochondrial Energy Fluxes. Cell Reports. 24: 3593-3606.e10. PMID 30257218 DOI: 10.1016/J.Celrep.2018.08.091 |
0.342 |
|
| 2018 |
Khodabukus A, Madden L, Prabhu NK, Koves TR, Jackman CP, Muoio DM, Bursac N. Electrical stimulation increases hypertrophy and metabolic flux in tissue-engineered human skeletal muscle. Biomaterials. PMID 30180985 DOI: 10.1016/J.Biomaterials.2018.08.058 |
0.411 |
|
| 2018 |
Wang Y, Christopher BA, Wilson KA, Muoio D, McGarrah RW, Brunengraber H, Zhang GF. Propionate-induced changes in cardiac metabolism, notably CoA trapping, are not altered by L-carnitine. American Journal of Physiology. Endocrinology and Metabolism. PMID 30016154 DOI: 10.1152/Ajpendo.00081.2018 |
0.457 |
|
| 2018 |
An J, Wang L, Patnode ML, Ridaura VK, Haldeman JM, Stevens RD, Ilkayeva O, Bain JR, Muehlbauer MJ, Glynn EL, Thomas S, Muoio D, Summers SA, Vath JE, Hughes TE, et al. Physiological mechanisms of sustained fumagillin-induced weight loss. Jci Insight. 3. PMID 29515039 DOI: 10.1172/Jci.Insight.99453 |
0.307 |
|
| 2018 |
Ho K, Zhang L, Wagg C, Gopal K, Levasseur J, Leone T, Dyck J, Ussher J, Muoio D, Kelly D, Lopaschuk G. Increasing fatty acid oxidation in the failing heart does not improve cardiac function Journal of Molecular and Cellular Cardiology. 124: 113-114. DOI: 10.1016/J.Yjmcc.2018.07.091 |
0.357 |
|
| 2017 |
Stöckli J, Fisher-Wellman KH, Chaudhuri R, Zeng XY, Fazakerley DJ, Meoli CC, Thomas KC, Hoffman NJ, Mangiafico SP, Xirouchaki CE, Yang CH, Ilkayeva O, Wong K, Cooney GJ, Andrikopoulos S, ... Muoio DM, et al. Metabolomic analysis of insulin resistance across different mouse strains and diets. The Journal of Biological Chemistry. PMID 28982973 DOI: 10.1074/Jbc.M117.818351 |
0.42 |
|
| 2017 |
Krycer JR, Fisher-Wellman KH, Fazakerley DJ, Muoio DM, James DE. Bicarbonate alters cellular responses in respiration assays. Biochemical and Biophysical Research Communications. PMID 28559140 DOI: 10.1016/J.Bbrc.2017.05.151 |
0.376 |
|
| 2017 |
Anderson KA, Huynh FK, Fisher-Wellman K, Stuart JD, Peterson BS, Douros JD, Wagner GR, Thompson JW, Madsen AS, Green MF, Sivley RM, Ilkayeva OR, Stevens RD, Backos DS, Capra JA, ... ... Muoio DM, et al. SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion. Cell Metabolism. 25: 838-855.e15. PMID 28380376 DOI: 10.1016/J.Cmet.2017.03.003 |
0.482 |
|
| 2017 |
Muoio DM. HDAC3 sets the timer on muscle fuel switching. Nature Medicine. 23: 148-150. PMID 28170378 DOI: 10.1038/Nm.4282 |
0.37 |
|
| 2016 |
Consitt LA, Koves TR, Muoio DM, Nakazawa M, Newton CA, Houmard JA. Plasma acylcarnitines during insulin stimulation in humans are reflective of age-related metabolic dysfunction. Biochemical and Biophysical Research Communications. PMID 27693789 DOI: 10.1016/J.Bbrc.2016.09.116 |
0.407 |
|
| 2016 |
Crown SB, Kelleher JK, Rouf R, Muoio DM, Antoniewicz M. Comprehensive metabolic modeling of multiple 13C-isotopomer data sets to study metabolism in perfused working hearts. American Journal of Physiology. Heart and Circulatory Physiology. ajpheart.00428.2016. PMID 27496880 DOI: 10.1152/Ajpheart.00428.2016 |
0.349 |
|
| 2016 |
Horton JL, Martin OJ, Lai L, Riley NM, Richards AL, Vega RB, Leone TC, Pagliarini DJ, Muoio DM, Bedi KC, Margulies KB, Coon JJ, Kelly DP. Mitochondrial protein hyperacetylation in the failing heart. Jci Insight. 2. PMID 26998524 DOI: 10.1172/Jci.Insight.84897 |
0.34 |
|
| 2016 |
Davies MN, Kjalarsdottir L, Thompson JW, Dubois LG, Stevens RD, Ilkayeva OR, Brosnan MJ, Rolph TP, Grimsrud PA, Muoio DM. The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins. Cell Reports. 14: 243-54. PMID 26748706 DOI: 10.1016/J.Celrep.2015.12.030 |
0.44 |
|
| 2015 |
Barrientos T, Laothamatas I, Koves TR, Soderblom EJ, Bryan M, Moseley MA, Muoio DM, Andrews NC. Metabolic Catastrophe in Mice Lacking Transferrin Receptor in Muscle. Ebiomedicine. 2: 1705-17. PMID 26870796 DOI: 10.1016/J.Ebiom.2015.09.041 |
0.412 |
|
| 2015 |
Huynh FK, Muoio DM, Hirschey MD. SIRT3 Directs Carbon Traffic in Muscle to Promote Glucose Control. Diabetes. 64: 3058-60. PMID 26294425 DOI: 10.2337/Db15-0709 |
0.41 |
|
| 2015 |
Kien CL, Matthews DE, Poynter ME, Bunn JY, Fukagawa NK, Crain KI, Ebenstein DB, Tarleton EK, Stevens RD, Koves TR, Muoio DM. Increased palmitate intake: higher acylcarnitine concentrations without impaired progression of β-oxidation. Journal of Lipid Research. 56: 1795-807. PMID 26156077 DOI: 10.1194/Jlr.M060137 |
0.329 |
|
| 2015 |
Seiler SE, Koves TR, Gooding JR, Wong KE, Stevens RD, Ilkayeva OR, Wittmann AH, DeBalsi KL, Davies MN, Lindeboom L, Schrauwen P, Schrauwen-Hinderling VB, Muoio DM. Carnitine Acetyltransferase Mitigates Metabolic Inertia and Muscle Fatigue during Exercise. Cell Metabolism. 22: 65-76. PMID 26154055 DOI: 10.1016/J.Cmet.2015.06.003 |
0.389 |
|
| 2015 |
Baker PR, Boyle KE, Koves TR, Ilkayeva OR, Muoio DM, Houmard JA, Friedman JE. Metabolomic analysis reveals altered skeletal muscle amino acid and fatty acid handling in obese humans. Obesity (Silver Spring, Md.). 23: 981-8. PMID 25864501 DOI: 10.1002/Oby.21046 |
0.464 |
|
| 2015 |
Fisher-Wellman KH, Lin CT, Ryan TE, Reese LR, Gilliam LA, Cathey BL, Lark DS, Smith CD, Muoio DM, Neufer PD. Pyruvate dehydrogenase complex and nicotinamide nucleotide transhydrogenase constitute an energy-consuming redox circuit. The Biochemical Journal. 467: 271-80. PMID 25643703 DOI: 10.1042/Bj20141447 |
0.369 |
|
| 2015 |
Wong KE, Mikus CR, Slentz DH, Seiler SE, DeBalsi KL, Ilkayeva OR, Crain KI, Kinter MT, Kien CL, Stevens RD, Muoio DM. Muscle-Specific Overexpression of PGC-1α Does Not Augment Metabolic Improvements in Response to Exercise and Caloric Restriction. Diabetes. 64: 1532-43. PMID 25422105 DOI: 10.2337/Db14-0827 |
0.507 |
|
| 2015 |
Li LO, Grevengoed TJ, Paul DS, Ilkayeva O, Koves TR, Pascual F, Newgard CB, Muoio DM, Coleman RA. Compartmentalized acyl-CoA metabolism in skeletal muscle regulates systemic glucose homeostasis. Diabetes. 64: 23-35. PMID 25071025 DOI: 10.2337/Db13-1070 |
0.76 |
|
| 2014 |
Muoio DM. Metabolic inflexibility: when mitochondrial indecision leads to metabolic gridlock. Cell. 159: 1253-62. PMID 25480291 DOI: 10.1016/J.Cell.2014.11.034 |
0.415 |
|
| 2014 |
Muoio DM, Newgard CB. Diabetes: The good in fat. Nature. 516: 49-50. PMID 25409152 DOI: 10.1038/Nature14070 |
0.355 |
|
| 2014 |
Lindeboom L, Nabuurs CI, Hoeks J, Brouwers B, Phielix E, Kooi ME, Hesselink MK, Wildberger JE, Stevens RD, Koves T, Muoio DM, Schrauwen P, Schrauwen-Hinderling VB. Long-echo time MR spectroscopy for skeletal muscle acetylcarnitine detection. The Journal of Clinical Investigation. 124: 4915-25. PMID 25271624 DOI: 10.1172/Jci74830 |
0.397 |
|
| 2014 |
Huffman KM, Koves TR, Hubal MJ, Abouassi H, Beri N, Bateman LA, Stevens RD, Ilkayeva OR, Hoffman EP, Muoio DM, Kraus WE. Metabolite signatures of exercise training in human skeletal muscle relate to mitochondrial remodelling and cardiometabolic fitness. Diabetologia. 57: 2282-95. PMID 25091629 DOI: 10.1007/S00125-014-3343-4 |
0.366 |
|
| 2014 |
Soni MS, Rabaglia ME, Bhatnagar S, Shang J, Ilkayeva O, Mynatt R, Zhou YP, Schadt EE, Thornberry NA, Muoio DM, Keller MP, Attie AD. Downregulation of carnitine acyl-carnitine translocase by miRNAs 132 and 212 amplifies glucose-stimulated insulin secretion. Diabetes. 63: 3805-14. PMID 24969106 DOI: 10.2337/Db13-1677 |
0.354 |
|
| 2014 |
Ussher JR, Keung W, Fillmore N, Koves TR, Mori J, Zhang L, Lopaschuk DG, Ilkayeva OR, Wagg CS, Jaswal JS, Muoio DM, Lopaschuk GD. Treatment with the 3-ketoacyl-CoA thiolase inhibitor trimetazidine does not exacerbate whole-body insulin resistance in obese mice. The Journal of Pharmacology and Experimental Therapeutics. 349: 487-96. PMID 24700885 DOI: 10.1124/Jpet.114.214197 |
0.497 |
|
| 2014 |
DeBalsi KL, Wong KE, Koves TR, Slentz DH, Seiler SE, Wittmann AH, Ilkayeva OR, Stevens RD, Perry CG, Lark DS, Hui ST, Szweda L, Neufer PD, Muoio DM. Targeted metabolomics connects thioredoxin-interacting protein (TXNIP) to mitochondrial fuel selection and regulation of specific oxidoreductase enzymes in skeletal muscle. The Journal of Biological Chemistry. 289: 8106-20. PMID 24482226 DOI: 10.1074/Jbc.M113.511535 |
0.481 |
|
| 2014 |
Kien CL, Bunn JY, Stevens R, Bain J, Ikayeva O, Crain K, Koves TR, Muoio DM. Dietary intake of palmitate and oleate has broad impact on systemic and tissue lipid profiles in humans American Journal of Clinical Nutrition. 99: 436-445. PMID 24429541 DOI: 10.3945/Ajcn.113.070557 |
0.355 |
|
| 2014 |
Seiler SE, Martin OJ, Noland RC, Slentz DH, DeBalsi KL, Ilkayeva OR, An J, Newgard CB, Koves TR, Muoio DM. Obesity and lipid stress inhibit carnitine acetyltransferase activity. Journal of Lipid Research. 55: 635-44. PMID 24395925 DOI: 10.1194/Jlr.M043448 |
0.497 |
|
| 2014 |
Martin OJ, Lai L, Soundarapandian MM, Leone TC, Zorzano A, Keller MP, Attie AD, Muoio DM, Kelly DP. A role for peroxisome proliferator-activated receptor γ coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth. Circulation Research. 114: 626-36. PMID 24366168 DOI: 10.1161/Circresaha.114.302562 |
0.312 |
|
| 2013 |
Wendel AA, Cooper DE, Ilkayeva OR, Muoio DM, Coleman RA. Glycerol-3-phosphate acyltransferase (GPAT)-1, but not GPAT4, incorporates newly synthesized fatty acids into triacylglycerol and diminishes fatty acid oxidation. The Journal of Biological Chemistry. 288: 27299-306. PMID 23908354 DOI: 10.1074/Jbc.M113.485219 |
0.728 |
|
| 2013 |
Laurent G, German NJ, Saha AK, de Boer VC, Davies M, Koves TR, Dephoure N, Fischer F, Boanca G, Vaitheesvaran B, Lovitch SB, Sharpe AH, Kurland IJ, Steegborn C, Gygi SP, ... Muoio DM, et al. SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase. Molecular Cell. 50: 686-98. PMID 23746352 DOI: 10.1016/J.Molcel.2013.05.012 |
0.513 |
|
| 2013 |
Kien CL, Bunn JY, Tompkins CL, Dumas JA, Crain KI, Ebenstein DB, Koves TR, Muoio DM. Substituting dietary monounsaturated fat for saturated fat is associated with increased daily physical activity and resting energy expenditure and with changes in mood. The American Journal of Clinical Nutrition. 97: 689-97. PMID 23446891 DOI: 10.3945/Ajcn.112.051730 |
0.357 |
|
| 2013 |
Kien CL, Bunn JY, Poynter ME, Stevens R, Bain J, Ikayeva O, Fukagawa NK, Champagne CM, Crain KI, Koves TR, Muoio DM. A lipidomics analysis of the relationship between dietary fatty acid composition and insulin sensitivity in young adults Diabetes. 62: 1054-1063. PMID 23238293 DOI: 10.2337/Db12-0363 |
0.398 |
|
| 2013 |
Jackson KC, Wohlers LM, Lovering RM, Schuh RA, Maher AC, Bonen A, Koves TR, Ilkayeva O, Thomson DM, Muoio DM, Spangenburg EE. Ectopic lipid deposition and the metabolic profile of skeletal muscle in ovariectomized mice. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 304: R206-17. PMID 23193112 DOI: 10.1152/Ajpregu.00428.2012 |
0.5 |
|
| 2013 |
Koves TR, Sparks LM, Kovalik JP, Mosedale M, Arumugam R, DeBalsi KL, Everingham K, Thorne L, Phielix E, Meex RC, Kien CL, Hesselink MK, Schrauwen P, Muoio DM. PPARγ coactivator-1α contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans. Journal of Lipid Research. 54: 522-34. PMID 23175776 DOI: 10.1194/Jlr.P028910 |
0.445 |
|
| 2012 |
Smith BK, Perry CG, Koves TR, Wright DC, Smith JC, Neufer PD, Muoio DM, Holloway GP. Identification of a novel malonyl-CoA IC(50) for CPT-I: implications for predicting in vivo fatty acid oxidation rates. The Biochemical Journal. 448: 13-20. PMID 22928974 DOI: 10.1042/Bj20121110 |
0.357 |
|
| 2012 |
Muoio DM. Revisiting the connection between intramyocellular lipids and insulin resistance: a long and winding road. Diabetologia. 55: 2551-2554. PMID 22660796 DOI: 10.1007/S00125-012-2597-Y |
0.409 |
|
| 2012 |
Muoio DM, Noland RC, Kovalik JP, Seiler SE, Davies MN, DeBalsi KL, Ilkayeva OR, Stevens RD, Kheterpal I, Zhang J, Covington JD, Bajpeyi S, Ravussin E, Kraus W, Koves TR, et al. Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility. Cell Metabolism. 15: 764-77. PMID 22560225 DOI: 10.1016/J.Cmet.2012.04.005 |
0.483 |
|
| 2012 |
Muoio DM, Neufer PD. Lipid-induced mitochondrial stress and insulin action in muscle. Cell Metabolism. 15: 595-605. PMID 22560212 DOI: 10.1016/J.Cmet.2012.04.010 |
0.491 |
|
| 2012 |
Watt MJ, Hoy AJ, Muoio DM, Coleman RA. Distinct roles of specific fatty acids in cellular processes: implications for interpreting and reporting experiments. American Journal of Physiology. Endocrinology and Metabolism. 302: E1-3. PMID 22180647 DOI: 10.1152/Ajpendo.00418.2011 |
0.595 |
|
| 2012 |
Koves T, Seiler S, DeBalsi K, Whitman A, Muoio D. Absence of malonyl-CoA decarboxylase (MCD) impacts endurance exercise capacity and reprograms skeletal muscle mitochondrial metabolism Mitochondrion. 12: 586. DOI: 10.1016/J.Mito.2012.07.091 |
0.404 |
|
| 2011 |
Miranda DA, Koves TR, Gross DA, Chadt A, Al-Hasani H, Cline GW, Schwartz GJ, Muoio DM, Silver DL. Re-patterning of skeletal muscle energy metabolism by fat storage-inducing transmembrane protein 2. The Journal of Biological Chemistry. 286: 42188-99. PMID 22002063 DOI: 10.1074/Jbc.M111.297127 |
0.494 |
|
| 2011 |
Kovalik JP, Slentz D, Stevens RD, Kraus WE, Houmard JA, Nicoll JB, Lea-Currie YR, Everingham K, Kien CL, Buehrer BM, Muoio DM. Metabolic remodeling of human skeletal myocytes by cocultured adipocytes depends on the lipolytic state of the system. Diabetes. 60: 1882-93. PMID 21602515 DOI: 10.2337/Db10-0427 |
0.401 |
|
| 2011 |
Ellis JM, Mentock SM, Depetrillo MA, Koves TR, Sen S, Watkins SM, Muoio DM, Cline GW, Taegtmeyer H, Shulman GI, Willis MS, Coleman RA. Mouse cardiac acyl coenzyme a synthetase 1 deficiency impairs Fatty Acid oxidation and induces cardiac hypertrophy. Molecular and Cellular Biology. 31: 1252-62. PMID 21245374 DOI: 10.1128/Mcb.01085-10 |
0.625 |
|
| 2011 |
Boyle KE, Canham JP, Consitt LA, Zheng D, Koves TR, Gavin TP, Holbert D, Neufer PD, Ilkayeva O, Muoio DM, Houmard JA. A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals. The Journal of Clinical Endocrinology and Metabolism. 96: 775-81. PMID 21190973 DOI: 10.1210/Jc.2010-2253 |
0.432 |
|
| 2011 |
Kien CL, Everingham KI, D Stevens R, Fukagawa NK, Muoio DM. Short-term effects of dietary fatty acids on muscle lipid composition and serum acylcarnitine profile in human subjects. Obesity (Silver Spring, Md.). 19: 305-11. PMID 20559306 DOI: 10.1038/Oby.2010.135 |
0.374 |
|
| 2010 |
Chen JL, Merl D, Peterson CW, Wu J, Liu PY, Yin H, Muoio DM, Ayer DE, West M, Chi JT. Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA. Plos Genetics. 6: e1001093. PMID 20844768 DOI: 10.1371/Journal.Pgen.1001093 |
0.358 |
|
| 2010 |
Muoio DM. Metabolism and vascular fatty acid transport. The New England Journal of Medicine. 363: 291-3. PMID 20647206 DOI: 10.1056/Nejmcibr1005397 |
0.383 |
|
| 2010 |
Ellis JM, Li LO, Wu PC, Koves TR, Ilkayeva O, Stevens RD, Watkins SM, Muoio DM, Coleman RA. Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis. Cell Metabolism. 12: 53-64. PMID 20620995 DOI: 10.1016/J.Cmet.2010.05.012 |
0.659 |
|
| 2010 |
Ussher JR, Koves TR, Cadete VJ, Zhang L, Jaswal JS, Swyrd SJ, Lopaschuk DG, Proctor SD, Keung W, Muoio DM, Lopaschuk GD. Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption. Diabetes. 59: 2453-64. PMID 20522596 DOI: 10.2337/Db09-1293 |
0.416 |
|
| 2010 |
Thyfault JP, Cree MG, Tapscott EB, Bell JA, Koves TR, Ilkayeva O, Wolfe RR, Dohm GL, Muoio DM. Metabolic profiling of muscle contraction in lean compared with obese rodents. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 299: R926-34. PMID 20504904 DOI: 10.1152/Ajpregu.00093.2010 |
0.451 |
|
| 2010 |
Bell JA, Reed MA, Consitt LA, Martin OJ, Haynie KR, Hulver MW, Muoio DM, Dohm GL. Lipid partitioning, incomplete fatty acid oxidation, and insulin signal transduction in primary human muscle cells: effects of severe obesity, fatty acid incubation, and fatty acid translocase/CD36 overexpression. The Journal of Clinical Endocrinology and Metabolism. 95: 3400-10. PMID 20427507 DOI: 10.1210/Jc.2009-1596 |
0.466 |
|
| 2010 |
Koonen DP, Sung MM, Kao CK, Dolinsky VW, Koves TR, Ilkayeva O, Jacobs RL, Vance DE, Light PE, Muoio DM, Febbraio M, Dyck JR. Alterations in skeletal muscle fatty acid handling predisposes middle-aged mice to diet-induced insulin resistance. Diabetes. 59: 1366-75. PMID 20299464 DOI: 10.2337/Db09-1142 |
0.438 |
|
| 2010 |
Consitt LA, Bell JA, Koves TR, Muoio DM, Hulver MW, Haynie KR, Dohm GL, Houmard JA. Peroxisome proliferator-activated receptor-gamma coactivator-1alpha overexpression increases lipid oxidation in myocytes from extremely obese individuals. Diabetes. 59: 1407-15. PMID 20200320 DOI: 10.2337/Db09-1704 |
0.384 |
|
| 2010 |
Muoio DM. Intramuscular triacylglycerol and insulin resistance: guilty as charged or wrongly accused? Biochimica Et Biophysica Acta. 1801: 281-8. PMID 19958841 DOI: 10.1016/J.Bbalip.2009.11.007 |
0.452 |
|
| 2009 |
Bain JR, Stevens RD, Wenner BR, Ilkayeva O, Muoio DM, Newgard CB. Metabolomics applied to diabetes research: moving from information to knowledge. Diabetes. 58: 2429-43. PMID 19875619 DOI: 10.2337/Db09-0580 |
0.344 |
|
| 2009 |
Li LO, Ellis JM, Paich HA, Wang S, Gong N, Altshuller G, Thresher RJ, Koves TR, Watkins SM, Muoio DM, Cline GW, Shulman GI, Coleman RA. Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition. The Journal of Biological Chemistry. 284: 27816-26. PMID 19648649 DOI: 10.1074/Jbc.M109.022467 |
0.662 |
|
| 2009 |
Noland RC, Koves TR, Seiler SE, Lum H, Lust RM, Ilkayeva O, Stevens RD, Hegardt FG, Muoio DM. Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control. The Journal of Biological Chemistry. 284: 22840-52. PMID 19553674 DOI: 10.1074/Jbc.M109.032888 |
0.551 |
|
| 2009 |
Ussher JR, Koves TR, Jaswal JS, Zhang L, Ilkayeva O, Dyck JR, Muoio DM, Lopaschuk GD. Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase. Diabetes. 58: 1766-75. PMID 19478144 DOI: 10.2337/Db09-0011 |
0.523 |
|
| 2009 |
Lien LF, Haqq AM, Arlotto M, Slentz CA, Muehlbauer MJ, McMahon RL, Rochon J, Gallup D, Bain JR, Ilkayeva O, Wenner BR, Stevens RD, Millington DS, Muoio DM, Butler MD, et al. The STEDMAN project: biophysical, biochemical and metabolic effects of a behavioral weight loss intervention during weight loss, maintenance, and regain. Omics : a Journal of Integrative Biology. 13: 21-35. PMID 19290809 DOI: 10.1089/Omi.2008.0035 |
0.348 |
|
| 2009 |
Malakauskas SM, Kourany WM, Zhang XY, Lu D, Stevens RD, Koves TR, Hohmeier HE, Muoio DM, Newgard CB, Le TH. Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha. Molecular Endocrinology (Baltimore, Md.). 23: 881-92. PMID 19246514 DOI: 10.1210/Me.2008-0274 |
0.444 |
|
| 2009 |
Makowski L, Noland RC, Koves TR, Xing W, Ilkayeva OR, Muehlbauer MJ, Stevens RD, Muoio DM. Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 586-604. PMID 18945875 DOI: 10.1096/Fj.08-119420 |
0.503 |
|
| 2009 |
Malakauskas SM, Kourany WM, Zhang XY, Lu D, Stevens RD, Koves TR, Hohmeier HE, Muoio DM, Newgard CB, Le TH. Increased Insulin Sensitivity in Mice Lacking Collectrin, a Downstream Target of HNF-1α Endocrine Reviews. 30: 1837-1837. DOI: 10.1210/Edrv.30.3.9987 |
0.34 |
|
| 2008 |
Muoio DM, Newgard CB. Fatty acid oxidation and insulin action: when less is more. Diabetes. 57: 1455-6. PMID 18511446 DOI: 10.2337/Db08-0281 |
0.506 |
|
| 2008 |
Stoltzman CA, Peterson CW, Breen KT, Muoio DM, Billin AN, Ayer DE. Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression. Proceedings of the National Academy of Sciences of the United States of America. 105: 6912-7. PMID 18458340 DOI: 10.1073/Pnas.0712199105 |
0.352 |
|
| 2008 |
Muoio DM, Newgard CB. Mechanisms of disease:Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes. Nature Reviews. Molecular Cell Biology. 9: 193-205. PMID 18200017 DOI: 10.1038/Nrm2327 |
0.33 |
|
| 2008 |
Koves TR, Ussher JR, Noland RC, Slentz D, Mosedale M, Ilkayeva O, Bain J, Stevens R, Dyck JR, Newgard CB, Lopaschuk GD, Muoio DM. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metabolism. 7: 45-56. PMID 18177724 DOI: 10.1016/J.Cmet.2007.10.013 |
0.53 |
|
| 2007 |
Muoio DM, Koves TR. Lipid-induced metabolic dysfunction in skeletal muscle. Novartis Foundation Symposium. 286: 24-38; discussion 38. PMID 18269172 DOI: 10.1002/9780470985571.Ch4 |
0.516 |
|
| 2007 |
Muoio DM, Koves TR. Skeletal muscle adaptation to fatty acid depends on coordinated actions of the PPARs and PGC1 alpha: implications for metabolic disease. Applied Physiology, Nutrition, and Metabolism = Physiologie AppliquéE, Nutrition Et MéTabolisme. 32: 874-83. PMID 18059612 DOI: 10.1139/H07-083 |
0.416 |
|
| 2007 |
Muoio DM. TXNIP links redox circuitry to glucose control. Cell Metabolism. 5: 412-4. PMID 17550776 DOI: 10.1016/J.Cmet.2007.05.011 |
0.343 |
|
| 2007 |
Power RA, Hulver MW, Zhang JY, Dubois J, Marchand RM, Ilkayeva O, Muoio DM, Mynatt RL. Carnitine revisited: Potential use as adjunctive treatment in diabetes Diabetologia. 50: 824-832. PMID 17310372 DOI: 10.1007/S00125-007-0605-4 |
0.492 |
|
| 2007 |
Thyfault JP, Cree MG, Zheng D, Zwetsloot JJ, Tapscott EB, Koves TR, Ilkayeva O, Wolfe RR, Muoio DM, Dohm GL. Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism. American Journal of Physiology. Cell Physiology. 292: C729-39. PMID 17050616 DOI: 10.1152/Ajpcell.00311.2006 |
0.483 |
|
| 2006 |
Muoio DM, Newgard CB. Obesity-related derangements in metabolic regulation. Annual Review of Biochemistry. 75: 367-401. PMID 16756496 DOI: 10.1146/Annurev.Biochem.75.103004.142512 |
0.403 |
|
| 2006 |
Thyfault JP, Cree MG, Bell JA, Zwetsloot JJ, Koves TR, Wolfe RR, Muoio DM, Dohm GL. The Impact of Obesity, Muscle Contraction, and Insulin on Skeletal Muscle Lipids, A Metabolomic Approach Medicine & Science in Sports & Exercise. 38: S44. DOI: 10.1249/00005768-200611001-00171 |
0.411 |
|
| 2005 |
Hulver MW, Berggren JR, Carper MJ, Miyazaki M, Ntambi JM, Hoffman EP, Thyfault JP, Stevens R, Dohm GL, Houmard JA, Muoio DM. Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans. Cell Metabolism. 2: 251-61. PMID 16213227 DOI: 10.1016/J.Cmet.2005.09.002 |
0.45 |
|
| 2005 |
Koves TR, Li P, An J, Akimoto T, Slentz D, Ilkayeva O, Dohm GL, Yan Z, Newgard CB, Muoio DM. Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency. The Journal of Biological Chemistry. 280: 33588-98. PMID 16079133 DOI: 10.1074/Jbc.M507621200 |
0.488 |
|
| 2005 |
Muoio DM, Newgard CB. Metabolism: A is for adipokine. Nature. 436: 337-8. PMID 16034406 DOI: 10.1038/436337A |
0.388 |
|
| 2005 |
Hammond LE, Neschen S, Romanelli AJ, Cline GW, Ilkayeva OR, Shulman GI, Muoio DM, Coleman RA. Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs. The Journal of Biological Chemistry. 280: 25629-36. PMID 15878874 DOI: 10.1074/Jbc.M503181200 |
0.776 |
|
| 2005 |
Berggren JR, Tanner CJ, Koves TR, Muoio DM, Houmard JA. Glucose uptake in muscle cell cultures from endurance-trained men. Medicine and Science in Sports and Exercise. 37: 579-84. PMID 15809555 DOI: 10.1249/01.Mss.0000158180.11224.E8 |
0.375 |
|
| 2005 |
Koves TR, Noland RC, Bates AL, Henes ST, Muoio DM, Cortright RN. Subsarcolemmal and intermyofibrillar mitochondria play distinct roles in regulating skeletal muscle fatty acid metabolism American Journal of Physiology - Cell Physiology. 288. PMID 15647392 DOI: 10.1152/Ajpcell.00391.2004 |
0.465 |
|
| 2004 |
Muoio DM, Newgard CB. Biomedicine. Insulin resistance takes a trip through the ER. Science (New York, N.Y.). 306: 425-6. PMID 15486283 DOI: 10.1126/Science.1104680 |
0.362 |
|
| 2004 |
An J, Muoio DM, Shiota M, Fujimoto Y, Cline GW, Shulman GI, Koves TR, Stevens R, Millington D, Newgard CB. Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance Nature Medicine. 10: 268-274. PMID 14770177 DOI: 10.1038/Nm995 |
0.49 |
|
| 2002 |
Muoio DM, Lynis Dohm G. Peripheral metabolic actions of leptin. Best Practice & Research. Clinical Endocrinology & Metabolism. 16: 653-66. PMID 12468413 DOI: 10.1053/Beem.2002.0223 |
0.448 |
|
| 2002 |
Muoio DM, MacLean PS, Lang DB, Li S, Houmard JA, Way JM, Winegar DA, Corton JC, Dohm GL, Kraus WE. Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta. The Journal of Biological Chemistry. 277: 26089-97. PMID 12118038 DOI: 10.1074/Jbc.M203997200 |
0.48 |
|
| 2002 |
Kim JY, Koves TR, Yu GS, Gulick T, Cortright RN, Dohm GL, Muoio DM. Evidence of a malonyl-CoA-insensitive carnitine palmitoyltransferase I activity in red skeletal muscle. American Journal of Physiology. Endocrinology and Metabolism. 282: E1014-22. PMID 11934665 DOI: 10.1152/Ajpendo.00233.2001 |
0.446 |
|
| 2002 |
Muoio DM, Way JM, Tanner CJ, Winegar DA, Kliewer SA, Houmard JA, Kraus WE, Dohm GL. Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells. Diabetes. 51: 901-9. PMID 11916905 DOI: 10.2337/Diabetes.51.4.901 |
0.429 |
|
| 2000 |
Hackney AC, Muoio D, Meyer WR. The effect of sex steroid hormones on substrate oxidation during prolonged submaximal exercise in women Japanese Journal of Physiology. 50: 489-494. PMID 11120915 DOI: 10.2170/Jjphysiol.50.489 |
0.339 |
|
| 2000 |
Muoio DM, Lewin TM, Wiedmer P, Coleman RA. Acyl-CoAs are functionally channeled in liver: potential role of acyl-CoA synthetase. American Journal of Physiology. Endocrinology and Metabolism. 279: E1366-73. PMID 11093925 DOI: 10.1152/Ajpendo.2000.279.6.E1366 |
0.608 |
|
| 2000 |
Coleman RA, Lewin TM, Muoio DM. Physiological and nutritional regulation of enzymes of triacylglycerol synthesis. Annual Review of Nutrition. 20: 77-103. PMID 10940327 DOI: 10.1146/Annurev.Nutr.20.1.77 |
0.55 |
|
| 2000 |
Vidal-Puig AJ, Grujic D, Zhang CY, Hagen T, Boss O, Ido Y, Szczepanik A, Wade J, Mootha V, Cortright R, Muoio DM, Lowell BB. Energy metabolism in uncoupling protein 3 gene knockout mice Journal of Biological Chemistry. 275: 16258-16266. PMID 10748196 DOI: 10.1074/Jbc.M910179199 |
0.487 |
|
| 1999 |
Muoio DM, Dohm GL, Tapscott EB, Coleman RA. Leptin opposes insulin's effects on fatty acid partitioning in muscles isolated from obese ob/obmice. American Journal of Physiology. Endocrinology and Metabolism. 276: E913-E921. PMID 29590818 DOI: 10.1152/ajpendo.1999.276.5.E913 |
0.364 |
|
| 1999 |
Muoio DM, Dohm GL, Tapscott EB, Coleman RA. Leptin opposes insulin's effects on fatty acid partitioning in muscles isolated from obese ob/ob mice. The American Journal of Physiology. 276: E913-21. PMID 10329986 DOI: 10.1152/Ajpendo.1999.276.5.E913 |
0.632 |
|
| 1999 |
MUOIO DM, SEEFELD K, WITTERS LA, COLEMAN RA. AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target Biochemical Journal. 338: 783. DOI: 10.1042/Bj3380783 |
0.673 |
|
| 1999 |
MUOIO DM, SEEFELD K, WITTERS LA, COLEMAN RA. AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target Biochemical Journal. 338: 783-791. DOI: 10.1042/BJ3380783 |
0.423 |
|
| 1997 |
Muoio DM, Dohm GL, Fiedorek FT, Tapscott EB, Coleman RA, Dohn GL. Leptin directly alters lipid partitioning in skeletal muscle. Diabetes. 46: 1360-3. PMID 9231663 DOI: 10.2337/Diab.46.8.1360 |
0.656 |
|
| 1997 |
CORTRIGHT R, MUOIO D, DOHM G. Skeletal muscle lipid metabolism: A frontier for new insights into fuel homeostasis The Journal of Nutritional Biochemistry. 8: 228-245. DOI: 10.1016/S0955-2863(97)89660-X |
0.432 |
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