| Year |
Citation |
Score |
| 2017 |
Friedmann T. Gene therapy for spinomuscular atrophy: a biomedical advance, a missed opportunity for more equitable drug pricing. Gene Therapy. 24: 503-505. PMID 28639617 DOI: 10.1038/Gt.2017.48 |
0.317 |
|
| 2016 |
Friedmann T. An ASGCT Perspective on the National Academies Genome Editing Summit. Molecular Therapy : the Journal of the American Society of Gene Therapy. 24: 1-2. PMID 26854182 DOI: 10.1038/Mt.2015.228 |
0.348 |
|
| 2015 |
Friedmann T, Jonlin EC, King NM, Torbett BE, Wivel NA, Kaneda Y, Sadelain M. ASGCT and JSGT Joint Position Statement on Human Genomic Editing. Molecular Therapy : the Journal of the American Society of Gene Therapy. 23: 1282. PMID 26227250 DOI: 10.1038/Mt.2015.118 |
0.349 |
|
| 2015 |
Kang TH, Friedmann T. Alzheimer's disease shares gene expression aberrations with purinergic dysregulation of HPRT deficiency (Lesch-Nyhan disease). Neuroscience Letters. 590: 35-9. PMID 25636690 DOI: 10.1016/J.Neulet.2015.01.042 |
0.343 |
|
| 2013 |
Kang TH, Park Y, Bader JS, Friedmann T. The housekeeping gene hypoxanthine guanine phosphoribosyltransferase (HPRT) regulates multiple developmental and metabolic pathways of murine embryonic stem cell neuronal differentiation. Plos One. 8: e74967. PMID 24130677 DOI: 10.1371/Journal.Pone.0074967 |
0.352 |
|
| 2012 |
Corrigan-Curay J, Cohen-Haguenauer O, O'Reilly M, Ross SR, Fan H, Rosenberg N, Somia N, King N, Friedmann T, Dunbar C, Aiuti A, Naldini L, Baum C, von Kalle C, Kiem HP, et al. Challenges in vector and trial design using retroviral vectors for long-term gene correction in hematopoietic stem cell gene therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 1084-94. PMID 22652996 DOI: 10.1038/Mt.2012.93 |
0.331 |
|
| 2012 |
Friedmann T. The successful clinical use of viral vectors for human gene therapy. Preface. Methods in Enzymology. 507: xvii-xx. PMID 22365783 DOI: 10.1016/B978-0-12-386509-0.00027-2 |
0.376 |
|
| 2012 |
Mastrangelo L, Kim JE, Miyanohara A, Kang TH, Friedmann T. Purinergic signaling in human pluripotent stem cells is regulated by the housekeeping gene encoding hypoxanthine guanine phosphoribosyltransferase. Proceedings of the National Academy of Sciences of the United States of America. 109: 3377-82. PMID 22331909 DOI: 10.1073/Pnas.1118067109 |
0.347 |
|
| 2012 |
Guibinga GH, Hrustanovic G, Bouic K, Jinnah HA, Friedmann T. MicroRNA-mediated dysregulation of neural developmental genes in HPRT deficiency: clues for Lesch-Nyhan disease? Human Molecular Genetics. 21: 609-22. PMID 22042773 DOI: 10.1093/Hmg/Ddr495 |
0.381 |
|
| 2011 |
Kang TH, Guibinga GH, Jinnah HA, Friedmann T. HPRT deficiency coordinately dysregulates canonical Wnt and presenilin-1 signaling: a neuro-developmental regulatory role for a housekeeping gene? Plos One. 6: e16572. PMID 21305049 DOI: 10.1371/Journal.Pone.0016572 |
0.345 |
|
| 2010 |
Guibinga GH, Friedmann T. Preparation of pseudotyped lentiviral vectors resistant to inactivation by serum complement. Cold Spring Harbor Protocols. 2010: pdb.prot5420. PMID 20647353 DOI: 10.1101/Pdb.Prot5420 |
0.317 |
|
| 2010 |
Friedmann T. How close are we to gene doping? The Hastings Center Report. 40: 20-2. PMID 20391845 DOI: 10.1353/Hcr.0.0246 |
0.36 |
|
| 2010 |
Friedmann T, Rabin O, Frankel MS. Ethics. Gene doping and sport. Science (New York, N.Y.). 327: 647-8. PMID 20133558 DOI: 10.1126/Science.1177801 |
0.3 |
|
| 2010 |
Guibinga GH, Hsu S, Friedmann T. Deficiency of the housekeeping gene hypoxanthine-guanine phosphoribosyltransferase (HPRT) dysregulates neurogenesis. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 54-62. PMID 19672249 DOI: 10.1038/Mt.2009.178 |
0.322 |
|
| 2009 |
Nienhuis A, Friedmann T. An integrated funding mechanism for clinical trials in human gene therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 1117-8. PMID 19564863 DOI: 10.1038/Mt.2009.129 |
0.329 |
|
| 2008 |
Guibinga GH, Song S, Loring J, Friedmann T. Characterization of the gene delivery properties of baculoviral-based virosomal vectors. Journal of Virological Methods. 148: 277-82. PMID 18207578 DOI: 10.1016/J.Jviromet.2007.11.007 |
0.374 |
|
| 2007 |
Friedmann T. A decade of accomplishments: gene therapy and the ASGT. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1576-8. PMID 17710079 DOI: 10.1038/Sj.Mt.6300284 |
0.325 |
|
| 2007 |
Song S, Friedmann T. Tissue-specific aberrations of gene expression in HPRT-deficient mice: functional complexity in a monogenic disease? Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1432-43. PMID 17505472 DOI: 10.1038/Sj.Mt.6300199 |
0.382 |
|
| 2006 |
Hall JC, Dunlap JC, Friedmann T, van Heyningen V. Some Ethical Aspects of "Harm" in Sport Advances in Genetics. 51: 89-93. DOI: 10.1016/S0065-2660(06)51008-9 |
0.332 |
|
| 2006 |
Hall JC, Dunlap JC, Friedmann T, van Heyningen V. A Scientific Perspective Advances in Genetics. 51: 79-87. DOI: 10.1016/S0065-2660(06)51007-7 |
0.327 |
|
| 2006 |
Hall JC, Dunlap JC, Friedmann T, van Heyningen V. International Cooperation and Regulation: The Banbury Workshop (2002) Advances in Genetics. 51: 65-78. DOI: 10.1016/S0065-2660(06)51006-5 |
0.352 |
|
| 2006 |
Hall JC, Dunlap JC, Friedmann T, van Heyningen V. Ethics and Oversight in Clinical Trials: Attempts at Gene Doping Would Not Conform to Accepted Ethical Standards Advances in Genetics. 51: 51-63. DOI: 10.1016/S0065-2660(06)51005-3 |
0.35 |
|
| 2006 |
Hall JC, Dunlap JC, Friedmann T, van Heyningen V. Gene Transfer In Sports: An Opening Scenario For Genetic Enhancement of Normal "Human Traits" Advances in Genetics. 51: 37-49. DOI: 10.1016/S0065-2660(06)51004-1 |
0.357 |
|
| 2006 |
Hall JC, Dunlap JC, Friedmann T, van Heyningen V. Early Gene Transfer Experiments: Problems and Eventual Success Advances in Genetics. 51: 27-35. DOI: 10.1016/S0065-2660(06)51003-X |
0.355 |
|
| 2006 |
Hall JC, Dunlap JC, Friedmann T, van Heyningen V. The Scientific Basis for Gene Therapy: A New Concept in Medicine Advances in Genetics. 51: 11-25. DOI: 10.1016/S0065-2660(06)51002-8 |
0.381 |
|
| 2006 |
Guibinga GH, Song S, Loring J, Friedmann T. 531. Complexes of DNA-Cationic Liposomes with Baculovirus GP64 Envelope Fusion Protein Vesicles Demonstrate Enhanced Transfection Efficiency Molecular Therapy. 13: S204. DOI: 10.1016/J.Ymthe.2006.08.602 |
0.341 |
|
| 2006 |
Bhasker CR, Song S, Friedmann T. 335. Global Transcriptional Profiles of Murine C2C12 Myoblasts Treated with IGF-1 Molecular Therapy. 13: S127. DOI: 10.1016/J.Ymthe.2006.08.392 |
0.351 |
|
| 2006 |
Guo LT, King CC, Song S, Friedmann T. 223. Proteomic Analysis of the Striatum of Wild Type and HPRT-Deficient Mouse Molecular Therapy. 13: S85-S86. DOI: 10.1016/J.Ymthe.2006.08.248 |
0.319 |
|
| 2006 |
Song S, Ramana Bhasker C, Guo L, Friedmann T. 222. Aberrant Striatal Gene Expression in the Striatum of HPRT-Knockout Mouse Molecular Therapy. 13: S85. DOI: 10.1016/J.Ymthe.2006.08.247 |
0.374 |
|
| 2005 |
Friedmann T. Lessons for the stem cell discourse from the gene therapy experience. Perspectives in Biology and Medicine. 48: 585-91. PMID 16227669 DOI: 10.1353/Pbm.2005.0089 |
0.35 |
|
| 2005 |
Guibinga GH, Friedmann T. Baculovirus GP64-pseudotyped HIV-based lentivirus vectors are stabilized against complement inactivation by codisplay of decay accelerating factor (DAF) or of a GP64-DAF fusion protein. Molecular Therapy : the Journal of the American Society of Gene Therapy. 11: 645-51. PMID 15771967 DOI: 10.1016/J.Ymthe.2004.12.002 |
0.316 |
|
| 2005 |
Guibinga GH, Hinton AC, Miyanohara A, Friedmann T. 186. Secreted Extracellular Vesicles of Baculovirus GP64 Interact with Plasmid DNA to Enhance Transfection Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.189 |
0.342 |
|
| 2004 |
Friedmann T. Clinical gene therapy: lessons from the ether dome. Molecular Therapy : the Journal of the American Society of Gene Therapy. 10: 205-6. PMID 15294165 DOI: 10.1016/J.Ymthe.2004.07.009 |
0.318 |
|
| 2004 |
Hinton A, Friedmann T, Hayek A. 400. Transduction of Human Embryonic Stem Cells with Lentiviral Vectors: Variable Promoter Activity in Pluripotent Cells Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.347 |
0.368 |
|
| 2003 |
Friedmann T. Gene therapy's new era: a balance of unequivocal benefit and unequivocal harm. Molecular Therapy : the Journal of the American Society of Gene Therapy. 8: 5-7. PMID 12872762 DOI: 10.1016/S1525-0016(03)00190-4 |
0.354 |
|
| 2002 |
Guibinga GH, Miyanohara A, Esko JD, Friedmann T. Cell surface heparan sulfate is a receptor for attachment of envelope protein-free retrovirus-like particles and VSV-G pseudotyped MLV-derived retrovirus vectors to target cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 5: 538-46. PMID 11991744 DOI: 10.1006/Mthe.2002.0578 |
0.319 |
|
| 2001 |
Friedmann T. Stanfield Rogers: insights into virus vectors and failure of an early gene therapy model. Molecular Therapy : the Journal of the American Society of Gene Therapy. 4: 285-8. PMID 11592829 DOI: 10.1006/Mthe.2001.0454 |
0.329 |
|
| 2001 |
Okimoto T, Friedmann T, Miyanohara A. VSV-G envelope glycoprotein forms complexes with plasmid DNA and MLV retrovirus-like particles in cell-free conditions and enhances DNA transfection. Molecular Therapy : the Journal of the American Society of Gene Therapy. 4: 232-8. PMID 11545614 DOI: 10.1006/Mthe.2001.0443 |
0.328 |
|
| 2001 |
Friedmann T, Noguchi P, Mickelson C. The evolution of public review and oversight mechanisms in human gene transfer research: joint roles of the FDA and NIH. Current Opinion in Biotechnology. 12: 304-7. PMID 11404110 DOI: 10.1016/S0958-1669(00)00216-0 |
0.315 |
|
| 2000 |
Miyanohara A, Friedmann T. Viral vectors do the DNA shuffle. Nature Biotechnology. 18: 1244-5. PMID 11101799 DOI: 10.1038/82345 |
0.304 |
|
| 2000 |
Sharma S, Miyanohara A, Friedmann T. Separable mechanisms of attachment and cell uptake during retrovirus infection. Journal of Virology. 74: 10790-5. PMID 11044124 DOI: 10.1128/Jvi.74.22.10790-10795.2000 |
0.334 |
|
| 2000 |
Friedmann T. Changing roles for academia and industry in genetics and gene therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy. 1: 9-11. PMID 10933906 DOI: 10.1006/Mthe.1999.0015 |
0.315 |
|
| 2000 |
Friedmann T. Medical ethics. Principles for human gene therapy studies. Science (New York, N.Y.). 287: 2163-5. PMID 10744537 DOI: 10.1126/Science.287.5461.2163 |
0.346 |
|
| 1999 |
Buchschacher GL, Yu L, Murai F, Friedmann T, Miyanohara A. Association of murine leukemia virus pol with virions, independent of Gag-Pol expression. Journal of Virology. 73: 9632-7. PMID 10516075 DOI: 10.1128/Jvi.73.11.9632-9637.1999 |
0.331 |
|
| 1999 |
Friedmann T. In Vivo Gene Transfer with Retrovirus Vectors Nature Biotechnology. 17: 19-19. DOI: 10.1038/70138 |
0.355 |
|
| 1998 |
Abe A, Miyanohara A, Friedmann T. Polybrene increases the efficiency of gene transfer by lipofection. Gene Therapy. 5: 708-11. PMID 9797877 DOI: 10.1038/Sj.Gt.3300652 |
0.339 |
|
| 1998 |
Johnson LG, Mewshaw JP, Ni H, Friedmann T, Boucher RC, Olsen JC. Effect of host modification and age on airway epithelial gene transfer mediated by a murine leukemia virus-derived vector. Journal of Virology. 72: 8861-72. PMID 9765431 DOI: 10.1128/Jvi.72.11.8861-8872.1998 |
0.372 |
|
| 1998 |
Abe A, Chen ST, Miyanohara A, Friedmann T. In vitro cell-free conversion of noninfectious Moloney retrovirus particles to an infectious form by the addition of the vesicular stomatitis virus surrogate envelope G protein. Journal of Virology. 72: 6356-61. PMID 9658075 DOI: 10.1128/Jvi.72.8.6356-6361.1998 |
0.349 |
|
| 1998 |
Abe A, Miyanohara A, Friedmann T. Enhanced gene transfer with fusogenic liposomes containing vesicular stomatitis virus G glycoprotein. Journal of Virology. 72: 6159-63. PMID 9621082 DOI: 10.1128/Jvi.72.7.6159-6163.1998 |
0.332 |
|
| 1997 |
Friedmann T. The road toward human gene therapy--a 25-year perspective. Annals of Medicine. 29: 575-7. PMID 9562527 DOI: 10.3109/07853899709007485 |
0.374 |
|
| 1997 |
Sharma S, Murai F, Miyanohara A, Friedmann T. Noninfectious virus-like particles produced by Moloney murine leukemia virus-based retrovirus packaging cells deficient in viral envelope become infectious in the presence of lipofection reagents. Proceedings of the National Academy of Sciences of the United States of America. 94: 10803-8. PMID 9380714 DOI: 10.1073/Pnas.94.20.10803 |
0.328 |
|
| 1997 |
Laitinen M, Pakkanen T, Donetti E, Baetta R, Luoma J, Lehtolainen P, Viita H, Agrawal R, Miyanohara A, Friedmann T, Risau W, Martin JF, Soma M, Ylä-Herttuala S. Gene transfer into the carotid artery using an adventitial collar: comparison of the effectiveness of the plasmid-liposome complexes, retroviruses, pseudotyped retroviruses, and adenoviruses. Human Gene Therapy. 8: 1645-50. PMID 9322866 DOI: 10.1089/Hum.1997.8.14-1645 |
0.372 |
|
| 1997 |
Friedmann T. Overcoming the obstacles to gene therapy. Scientific American. 276: 96-101. PMID 9163941 DOI: 10.1038/Scientificamerican0697-95 |
0.335 |
|
| 1996 |
Cantwell MJ, Sharma S, Friedmann T, Kipps TJ. Adenovirus vector infection of chronic lymphocytic leukemia B cells. Blood. 88: 4676-83. PMID 8977261 DOI: 10.1182/Blood.V88.12.4676.Bloodjournal88124676 |
0.353 |
|
| 1996 |
Friedmann T. The maturation of human gene therapy. Acta Paediatrica (Oslo, Norway : 1992). 85: 1261-5. PMID 8955449 DOI: 10.1111/J.1651-2227.1996.Tb13908.X |
0.349 |
|
| 1996 |
Burns JC, McNeill L, Shimizu C, Matsubara T, Yee JK, Friedmann T, Kurdi-Haidar B, Maliwat E, Holt CE. Retrovirol gene transfer in Xenopus cell lines and embryos. In Vitro Cellular & Developmental Biology. Animal. 32: 78-84. PMID 8907120 DOI: 10.1007/Bf02723038 |
0.414 |
|
| 1996 |
Sharma S, Cantwell M, Kipps TJ, Friedmann T. Efficient infection of a human T-cell line and of human primary peripheral blood leukocytes with a pseudotyped retrovirus vector. Proceedings of the National Academy of Sciences of the United States of America. 93: 11842-7. PMID 8876225 DOI: 10.1073/Pnas.93.21.11842 |
0.395 |
|
| 1996 |
Kurdi-Haidar B, Friedmann T. Simplified plasmid rescue of host sequences adjacent to integrated proviruses. Gene. 168: 199-203. PMID 8654944 DOI: 10.1016/0378-1119(95)00753-9 |
0.373 |
|
| 1996 |
Friedmann T. Human gene therapy--an immature genie, but certainly out of the bottle. Nature Medicine. 2: 144-7. PMID 8574951 DOI: 10.1038/Nm0296-144 |
0.341 |
|
| 1995 |
Van Meir EG, Roemer K, Diserens AC, Kikuchi T, Rempel SA, Haas M, Huang HJ, Friedmann T, de Tribolet N, Cavenee WK. Single cell monitoring of growth arrest and morphological changes induced by transfer of wild-type p53 alleles to glioblastoma cells. Proceedings of the National Academy of Sciences of the United States of America. 92: 1008-12. PMID 7862624 DOI: 10.1073/Pnas.92.4.1008 |
0.334 |
|
| 1995 |
Jinnah HA, Friedmann T. Gene therapy and the brain. British Medical Bulletin. 51: 138-48. PMID 7767640 DOI: 10.1093/Oxfordjournals.Bmb.A072943 |
0.323 |
|
| 1995 |
Roemer K, Johnson PA, Friedmann T. Transduction of foreign regulatory sequences by a replication-defective herpes simplex virus type 1: the rat neuron-specific enolase promoter. Virus Research. 35: 81-9. PMID 7754677 DOI: 10.1016/0168-1702(94)00083-O |
0.622 |
|
| 1995 |
Wang MJ, Friedmann T, Johnson PA. Differentiation of PC12 cells by infection with an HSV-1 vector expressing nerve growth factor. Gene Therapy. 2: 323-35. PMID 7671108 |
0.542 |
|
| 1995 |
Friedmann T, Yee JK. Pseudotyped retroviral vectors for studies of human gene therapy. Nature Medicine. 1: 275-7. PMID 7585046 DOI: 10.1038/Nm0395-275 |
0.376 |
|
| 1995 |
Friedmann T. Lesch-Nyhan disease as a model for central nervous system directed gene therapy Mental Retardation and Developmental Disabilities Research Reviews. 1: 49-55. DOI: 10.1002/Mrdd.1410010110 |
0.358 |
|
| 1995 |
de la Cruz F, Friedmann T. Prospects for human gene therapy in mental retardation and developmental disabilities Mental Retardation and Developmental Disabilities Research Reviews. 1: 2-3. DOI: 10.1002/Mrdd.1410010103 |
0.321 |
|
| 1994 |
Burns JC, Matsubara T, Lozinski G, Yee JK, Friedmann T, Washabaugh CH, Tsonis PA. Pantropic retroviral vector-mediated gene transfer, integration, and expression in cultured newt limb cells. Developmental Biology. 165: 285-9. PMID 8088445 DOI: 10.1006/Dbio.1994.1253 |
0.405 |
|
| 1994 |
Johnson PA, Wang MJ, Friedmann T. Improved cell survival by the reduction of immediate-early gene expression in replication-defective mutants of herpes simplex virus type 1 but not by mutation of the virion host shutoff function. Journal of Virology. 68: 6347-62. PMID 8083974 DOI: 10.1128/Jvi.68.10.6347-6362.1994 |
0.616 |
|
| 1994 |
Friedmann T. Gene therapy for neurological disorders. Trends in Genetics : Tig. 10: 210-4. PMID 8073535 DOI: 10.1016/0168-9525(94)90258-5 |
0.317 |
|
| 1994 |
Lin S, Gaiano N, Culp P, Burns JC, Friedmann T, Yee JK, Hopkins N. Integration and germ-line transmission of a pseudotyped retroviral vector in zebrafish. Science (New York, N.Y.). 265: 666-9. PMID 8036514 DOI: 10.1126/Science.8036514 |
0.357 |
|
| 1994 |
Yee JK, Miyanohara A, LaPorte P, Bouic K, Burns JC, Friedmann T. A general method for the generation of high-titer, pantropic retroviral vectors: highly efficient infection of primary hepatocytes. Proceedings of the National Academy of Sciences of the United States of America. 91: 9564-8. PMID 7937806 DOI: 10.1073/Pnas.91.20.9564 |
0.411 |
|
| 1994 |
Yee JK, Friedmann T, Burns JC. Generation of high-titer pseudotyped retroviral vectors with very broad host range. Methods in Cell Biology. 43: 99-112. PMID 7823872 DOI: 10.1016/S0091-679X(08)60600-7 |
0.402 |
|
| 1994 |
Johnson PA, Friedmann T. Replication-defective recombinant herpes simplex virus vectors. Methods in Cell Biology. 43: 211-30. PMID 7823863 DOI: 10.1016/S0091-679X(08)60605-6 |
0.599 |
|
| 1994 |
Lu M, Maruyama M, Zhang N, Levine F, Friedmann T, Ho AD. High efficiency retroviral-mediated gene transduction into CD34+ cells purified from peripheral blood of breast cancer patients primed with chemotherapy and granulocyte-macrophage colony-stimulating factor. Human Gene Therapy. 5: 203-8. PMID 7514449 DOI: 10.1089/Hum.1994.5.2-203 |
0.332 |
|
| 1993 |
Roemer K, Friedmann T. Modulation of cell proliferation and gene expression by a p53-estrogen receptor hybrid protein Proceedings of the National Academy of Sciences of the United States of America. 90: 9252-9256. PMID 8415687 DOI: 10.1073/Pnas.90.20.9252 |
0.309 |
|
| 1993 |
Burns JC, Friedmann T, Driever W, Burrascano M, Yee JK. Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 90: 8033-7. PMID 8396259 DOI: 10.1073/Pnas.90.17.8033 |
0.416 |
|
| 1993 |
Abe A, Takeo T, Emi N, Tanimoto M, Ueda R, Yee JK, Friedmann T, Saito H. Transduction of a drug-sensitive toxic gene into human leukemia cell lines with a novel retroviral vector Proceedings of the Society For Experimental Biology and Medicine. 203: 354-359. PMID 8390693 DOI: 10.3181/00379727-203-43611 |
0.389 |
|
| 1993 |
Friedmann T. Milestone and events in the early development of human gene therapy Molecular Genetic Medicine. 3: 1-32. PMID 8220161 DOI: 10.1016/B978-0-12-462003-2.50005-5 |
0.335 |
|
| 1993 |
Friedmann T, Jinnah HA. Gene therapy for disorders of the nervous system Trends in Biotechnology. 11: 192-197. PMID 7763810 DOI: 10.1016/0167-7799(93)90113-N |
0.36 |
|
| 1993 |
Friedmann T. Gene therapy - a new kind of medicine Trends in Biotechnology. 11: 156-159. PMID 7763803 DOI: 10.1016/0167-7799(93)90106-J |
0.343 |
|
| 1992 |
Roemer K, Friedmann T. Concepts and strategies for human gene therapy European Journal of Biochemistry. 208: 211-225. PMID 1521521 DOI: 10.1111/J.1432-1033.1992.Tb17176.X |
0.408 |
|
| 1992 |
Roman M, Axelrod JH, Dai Y, Naviaux RK, Friedmann T, Verma IM. Circulating human or canine factor IX from retrovirally transduced primary myoblasts and established myoblast cell lines grafted into murine skeletal muscle. Somatic Cell and Molecular Genetics. 18: 247-58. PMID 1496420 DOI: 10.1007/Bf01233861 |
0.317 |
|
| 1992 |
Friedmann T. Approaches to gene therapy of complex multigenic diseases: cancer as a model and implications for cardiovascular disease and diabetes. Annals of Medicine. 24: 411-7. PMID 1418928 DOI: 10.3109/07853899209147847 |
0.311 |
|
| 1992 |
Johnson PA, Miyanohara A, Levine F, Cahill T, Friedmann T. Cytotoxicity of a replication-defective mutant of herpes simplex virus type 1. Journal of Virology. 66: 2952-65. PMID 1373198 DOI: 10.1128/Jvi.66.5.2952-2965.1992 |
0.632 |
|
| 1992 |
Roemer K, Johnson PA, Friedmann T. Recombination between a herpes simplex virus type 1 vector deleted for immediate early gene 3 and the infected cell genome. The Journal of General Virology. 73: 1553-8. PMID 1318949 DOI: 10.1099/0022-1317-73-6-1553 |
0.631 |
|
| 1992 |
Miyanohara A, Johnson PA, Elam RL, Dai Y, Witztum JL, Verma IM, Friedmann T. Direct gene transfer to the liver with herpes simplex virus type 1 vectors: transient production of physiologically relevant levels of circulating factor IX. The New Biologist. 4: 238-46. PMID 1316145 |
0.537 |
|
| 1992 |
Johnson PA, Yoshida K, Gage FH, Friedmann T. Effects of gene transfer into cultured CNS neurons with a replication-defective herpes simplex virus type 1 vector. Brain Research. Molecular Brain Research. 12: 95-102. PMID 1312210 DOI: 10.1016/0169-328X(92)90072-J |
0.595 |
|
| 1992 |
Friedmann T. A brief history of gene therapy Nature Genetics. 2: 93-98. PMID 1303270 DOI: 10.1038/Ng1092-93 |
0.42 |
|
| 1991 |
Friedmann T. The evolving concept of gene therapy. Human Gene Therapy. 1: 175-81. PMID 2078579 DOI: 10.1089/Hum.1990.1.2-175 |
0.391 |
|
| 1991 |
Roemer K, Johnson PA, Friedmann T. Knock-in and knock-out. Transgenes, Development and Disease: A Keystone Symposium sponsored by Genentech and Immunex, Tamarron, CO, USA, January 12-18, 1991. The New Biologist. 3: 331-5. PMID 2065017 |
0.491 |
|
| 1991 |
Emi N, Friedmann T, Yee JK. Pseudotype formation of murine leukemia virus with the G protein of vesicular stomatitis virus. Journal of Virology. 65: 1202-7. PMID 1847450 DOI: 10.1128/Jvi.65.3.1202-1207.1991 |
0.34 |
|
| 1991 |
Johnson PA, Best MG, Friedmann T, Parris DS. Isolation of a herpes simplex virus type 1 mutant deleted for the essential UL42 gene and characterization of its null phenotype. Journal of Virology. 65: 700-10. PMID 1846193 DOI: 10.1128/Jvi.65.2.700-710.1991 |
0.618 |
|
| 1991 |
Levine F, Jiing Kuan Yee, Friedmann T. Efficient gene expression in mammalian cells from a dicistronic transcriptional unit in an improved retroviral vector Gene. 108: 167-174. PMID 1660834 DOI: 10.1016/0378-1119(91)90431-A |
0.434 |
|
| 1991 |
Roemer K, Johnson PA, Friedmann T. Activity of the simian virus 40 early promoter-enhancer in herpes simplex virus type 1 vectors is dependent on its position, the infected cell type, and the presence of Vmw175. Journal of Virology. 65: 6900-12. PMID 1658381 DOI: 10.1128/Jvi.65.12.6900-6912.1991 |
0.629 |
|
| 1991 |
Levine F, Friedmann T. Gene therapy techniques Current Opinion in Biotechnology. 2: 840-844. PMID 1367958 DOI: 10.1016/S0958-1669(05)80117-X |
0.342 |
|
| 1990 |
Johnson P, Friedmann T. Limited bidirectional activity of two housekeeping gene promoters: human HPRT and PGK. Gene. 88: 207-13. PMID 2347494 DOI: 10.1016/0378-1119(90)90033-N |
0.581 |
|
| 1990 |
Short MP, Rosenberg MB, Ezzedine ZD, Gage FH, Friedmann T, Breakefield XO. Autocrine differentiation of PC12 cells mediated by retroviral vectors. Developmental Neuroscience. 12: 34-45. PMID 2105198 DOI: 10.1159/000111833 |
0.333 |
|
| 1990 |
Gage FH, Rosenberg MB, Tuszynski MH, Yoshida K, Armstrong DM, Hayes RC, Friedmann T. Gene therapy in the CNS: intracerebral grafting of genetically modified cells. Progress in Brain Research. 86: 205-17. PMID 2087558 DOI: 10.1016/S0079-6123(08)63178-7 |
0.347 |
|
| 1990 |
Gage FH, Fisher LJ, Jinnah HA, Rosenberg MB, Tuszynski MH, Friedmann T. Grafting genetically modified cells to the brain: conceptual and technical issues. Progress in Brain Research. 82: 1-10. PMID 1981271 DOI: 10.1016/S0079-6123(08)62584-4 |
0.368 |
|
| 1989 |
Friedmann T. Progress toward human gene therapy. Science (New York, N.Y.). 244: 1275-81. PMID 2660259 DOI: 10.1126/Science.2660259 |
0.389 |
|
| 1989 |
Wolff JA, Fisher LJ, Xu L, Jinnah HA, Langlais PJ, Iuvone PM, O'Malley KL, Rosenberg MB, Shimohama S, Friedmann T. Grafting fibroblasts genetically modified to produce L-dopa in a rat model of Parkinson disease. Proceedings of the National Academy of Sciences of the United States of America. 86: 9011-4. PMID 2573072 DOI: 10.1073/Pnas.86.22.9011 |
0.31 |
|
| 1989 |
Xu L, Yee JK, Wolff JA, Friedmann T. Factors affecting long-term stability of Moloney murine leukemia virus-based vectors. Virology. 171: 331-41. PMID 2503932 DOI: 10.1016/0042-6822(89)90600-4 |
0.425 |
|
| 1989 |
Shimohama S, Rosenberg MB, Fagan AM, Wolff JA, Short MP, Breakefield XO, Friedmann T, Gage FH. Grafting genetically modified cells into the rat brain: characteristics of E. coli beta-galactosidase as a reporter gene. Brain Research. Molecular Brain Research. 5: 271-8. PMID 2501628 DOI: 10.1016/0169-328X(89)90061-2 |
0.311 |
|
| 1988 |
Huang HJ, Yee JK, Shew JY, Chen PL, Bookstein R, Friedmann T, Lee EY, Lee WH. Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells. Science (New York, N.Y.). 242: 1563-6. PMID 3201247 DOI: 10.1126/Science.3201247 |
0.396 |
|
| 1988 |
Gage FH, Wolff JA, Rosenberg MB, Xu L, Yee JK, Shults C, Friedmann T. Implantation of genetically engineered cells to the brain. Progress in Brain Research. 78: 651-8. PMID 2907815 DOI: 10.1016/S0079-6123(08)60345-3 |
0.358 |
|
| 1988 |
Bookstein R, Lee EY, To H, Young LJ, Sery TW, Hayes RC, Friedmann T, Lee WH. Human retinoblastoma susceptibility gene: genomic organization and analysis of heterozygous intragenic deletion mutants. Proceedings of the National Academy of Sciences of the United States of America. 85: 2210-4. PMID 2895471 DOI: 10.1073/Pnas.85.7.2210 |
0.399 |
|
| 1988 |
Miyanohara A, Sharkey MF, Witztum JL, Steinberg D, Friedmann T. Efficient expression of retroviral vector-transduced human low density lipoprotein (LDL) receptor in LDL receptor-deficient rabbit fibroblasts in vitro. Proceedings of the National Academy of Sciences of the United States of America. 85: 6538-42. PMID 2842777 DOI: 10.1073/Pnas.85.17.6538 |
0.323 |
|
| 1988 |
Johnson PA, Friedmann T. 69 THE HPRT PROMOTER Pediatric Research. 24: 122-122. DOI: 10.1203/00006450-198807000-00093 |
0.381 |
|
| 1988 |
Chang H, Jolly DJ, Biro E, Jones OW, Friedmann T. Chromosomal sublocalization of human gene sequences by in situ hybridization Journal of Tissue Culture Methods. 11: 1-8. DOI: 10.1007/Bf01404406 |
0.317 |
|
| 1987 |
Friedmann T. Scientific and policy progress toward gene therapy. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 3: 40-1. PMID 3870346 DOI: 10.1002/Bies.950030111 |
0.302 |
|
| 1987 |
Wolff JA, Yee JK, Skelly H, Moores J, Respess J, Friedmann T, Leffert H. Adult mammalian hepatocyte as target cell for retroviral gene transfer: a model for gene therapy. Somatic Cell and Molecular Genetics. 13: 423-8. PMID 3484086 DOI: 10.1007/Bf01534943 |
0.363 |
|
| 1987 |
Jolly DJ, Yee JK, Friedmann T. High-efficiency gene transfer into cells. Methods in Enzymology. 149: 10-25. PMID 3480408 DOI: 10.1016/0076-6879(87)49040-X |
0.417 |
|
| 1987 |
Yee JK, Moores JC, Jolly DJ, Wolff JA, Respess JG, Friedmann T. Gene expression from transcriptionally disabled retroviral vectors. Proceedings of the National Academy of Sciences of the United States of America. 84: 5197-201. PMID 3474647 DOI: 10.1073/Pnas.84.15.5197 |
0.433 |
|
| 1987 |
Gage FH, Wolff JA, Rosenberg MB, Xu L, Yee JK, Shults C, Friedmann T. Grafting genetically modified cells to the brain: possibilities for the future. Neuroscience. 23: 795-807. PMID 3325854 DOI: 10.1016/0306-4522(87)90159-X |
0.313 |
|
| 1987 |
Wolff JA, Yee JK, Skelly HF, Moores JC, Respess JG, Friedmann T, Leffert H. Expression of retrovirally transduced genes in primary cultures of adult rat hepatocytes. Proceedings of the National Academy of Sciences of the United States of America. 84: 3344-8. PMID 3033644 DOI: 10.1073/Pnas.84.10.3344 |
0.348 |
|
| 1987 |
Yee JK, Jolly DJ, Miller AD, Willis R, Wolff J, Friedmann T. Epitope insertion into the human hypoxanthine phosphoribosyltransferase protein and detection of the mutant protein by an anti-peptide antibody. Gene. 53: 97-104. PMID 2439408 DOI: 10.1016/0378-1119(87)90096-5 |
0.377 |
|
| 1986 |
Yee JK, Jolly DJ, Moores JC, Respess JG, Friedmann T. Gene expression from a transcriptionally disabled retroviral vector. Cold Spring Harbor Symposia On Quantitative Biology. 51: 1021-6. PMID 3034493 DOI: 10.1101/Sqb.1986.051.01.117 |
0.358 |
|
| 1986 |
Gruber HE, Finley KD, Luchtman LA, Hershberg RM, Katzman SS, Laikind PK, Meyers EN, Seegmiller JE, Friedmann T, Yee JK. Insertion of hypoxanthine phosphoribosyltransferase cDNA into human bone marrow cells by a retrovirus. Advances in Experimental Medicine and Biology. 195: 171-5. PMID 3014831 |
0.435 |
|
| 1986 |
Kim SH, Moores JC, David D, Respess JG, Jolly DJ, Friedmann T. The organization of the human HPRT gene Nucleic Acids Research. 14: 3103-3118. PMID 3008106 DOI: 10.1093/Nar/14.7.3103 |
0.41 |
|
| 1985 |
Gruber HE, Finley KD, Hershberg RM, Katzman SS, Laikind PK, Seegmiller JE, Friedmann T, Yee JK, Jolly DJ. Retroviral vector-mediated gene transfer into human hematopoietic progenitor cells. Science (New York, N.Y.). 230: 1057-61. PMID 3864246 DOI: 10.1126/Science.3864246 |
0.578 |
|
| 1985 |
Yee J, Jolly DJ, Friedmann T. AN ALTERED HPRT PROTEIN, CREATED BY AN IN VITRO MUTAGENESIS OF THE GENE, CAN BE RECOGNIZED SPECIF: CALLY BY AN ANTIPEPTIDE ANTIBODY: 235 Pediatric Research. 19: 783-783. DOI: 10.1203/00006450-198507000-00255 |
0.318 |
|
| 1985 |
Kim SH, Moores J, Respess JG, David D, Jolly DJ, Friedmann T. ORGANIZATION OF THE HUMAN HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE GENE: 101 Pediatric Research. 19: 760-760. DOI: 10.1203/00006450-198507000-00121 |
0.331 |
|
| 1985 |
Gruber HE, Friedmann T, Finley KD, Katzman S, Laikind PK, Hershberg RM, Luchtman LA, Seegmiller JE, Jolly DJ. INSERTION OF HYPOXAKTHINE PHOSPHORIBOSYLTRANSFERASE (HPRT) cDNA INTO HUMAN BONE MARROW CELLS (BMC) A RETROVIRUS VECTOR: 75 Pediatric Research. 19: 756-756. DOI: 10.1203/00006450-198507000-00095 |
0.511 |
|
| 1985 |
Jolly DJ, Willis RC, Friedmann T. 834 STABILITY OF GENE TRANSFER IN LESCH NYHAN CELLS Pediatric Research. 19: 249A-249A. DOI: 10.1203/00006450-198504000-00864 |
0.436 |
|
| 1984 |
Miller AD, Eckner RJ, Jolly DJ, Friedmann T, Verma IM. Expression of a retrovirus encoding human HPRT in mice. Science (New York, N.Y.). 225: 630-2. PMID 6377498 DOI: 10.1126/Science.6377498 |
0.374 |
|
| 1984 |
Willis RC, Jolly DJ, Miller AD, Plent MM, Esty AC, Anderson PJ, Chang HC, Jones OW, Seegmiller JE, Friedmann T. Partial phenotypic correction of human Lesch-Nyhan (hypoxanthine-guanine phosphoribosyltransferase-deficient) lymphoblasts with a transmissible retroviral vector. The Journal of Biological Chemistry. 259: 7842-9. PMID 6203897 |
0.53 |
|
| 1983 |
Miller AD, Jolly DJ, Friedmann T, Verma IM. A transmissible retrovirus expressing human hypoxanthine phosphoribosyltransferase (HPRT): gene transfer into cells obtained from humans deficient in HPRT. Proceedings of the National Academy of Sciences of the United States of America. 80: 4709-13. PMID 6308645 DOI: 10.1073/Pnas.80.15.4709 |
0.422 |
|
| 1983 |
Jolly DJ, Okayama H, Berg P, Esty AC, Filpula D, Bohlen P, Johnson GG, Shively JE, Hunkapillar T, Friedmann T. Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase. Proceedings of the National Academy of Sciences of the United States of America. 80: 477-81. PMID 6300847 DOI: 10.1073/Pnas.80.2.477 |
0.376 |
|
| 1983 |
Jolly DJ, Esty AC, Subramani S, Friedmann T, Verma IM. Elements in the long terminal repeat of murine retroviruses enhance stable transformation by thymidine kinase gene. Nucleic Acids Research. 11: 1855-72. PMID 6300781 DOI: 10.1093/Nar/11.6.1855 |
0.398 |
|
| 1982 |
Jolly DJ, Esty AC, Bernard HU, Friedmann T. Isolation of a genomic clone partially encoding human hypoxanthine phosphoribosyltransferase. Proceedings of the National Academy of Sciences of the United States of America. 79: 5038-41. PMID 6956912 DOI: 10.1073/Pnas.79.16.5038 |
0.368 |
|
| 1981 |
Deininger PL, Jolly DJ, Rubin CM, Friedmann T, Schmid CW. Base sequence studies of 300 nucleotide renatured repeated human DNA clones. Journal of Molecular Biology. 151: 17-33. PMID 6276559 DOI: 10.1016/0022-2836(81)90219-9 |
0.685 |
|
| 1981 |
Fuhrman SA, Deininger PL, LaPorte P, Friedmann T, Geiduschek EP. Analysis of transcription of the human Alu family ubiquitous repeating element by eukaryotic RNA polymerase III. Nucleic Acids Research. 9: 6439-56. PMID 6275362 DOI: 10.1093/Nar/9.23.6439 |
0.526 |
|
| 1981 |
Deininger PL, LaPorte P, Friedmann T. Nucleotide sequence changes in polyoma ts-a mutants: correlation with protein structure. Journal of Virology. 37: 871-5. PMID 6262533 DOI: 10.1128/Jvi.37.3.871-875.1981 |
0.528 |
|
| 1981 |
Fujimura FK, Deininger PL, Friedmann T, Linney E. Mutation near the polyoma DNA replication origin permits productive infection of F9 embryonal carcinoma cells. Cell. 23: 809-14. PMID 6261957 DOI: 10.1016/0092-8674(81)90445-1 |
0.568 |
|
| 1981 |
Srivatsan ES, Deininger PL, Friedmann T. Nucleotide sequence at polyoma VP1 mRNA splice sites. Journal of Virology. 37: 244-7. PMID 6260979 DOI: 10.1128/Jvi.37.1.244-247.1981 |
0.571 |
|
| 1981 |
Eckhart W, Delbrück S, Deininger P, Friedmann T, Hunter T. A mutation increasing the size of the polyoma virion proteins, VP2 and VP3. Virology. 109: 35-46. PMID 6258312 DOI: 10.1016/0042-6822(81)90469-4 |
0.56 |
|
| 1980 |
Hunter T, Hutchinson MA, Eckhart W, Friedmann T, Esty A, La Porte P, Deininger P. Organization of T antigens in the polyoma virus genome. Cold Spring Harbor Symposia On Quantitative Biology. 44: 131-9. PMID 6253126 DOI: 10.1101/Sqb.1980.044.01.015 |
0.528 |
|
| 1980 |
Rubin CM, Houck CM, Deininger PL, Friedmann T, Schmid CW. Partial nucleotide sequence of the 300-nucleotide interspersed repeated human DNA sequences. Nature. 284: 372-4. PMID 6244506 DOI: 10.1038/284372A0 |
0.678 |
|
| 1979 |
Hunter T, Hutchinson MA, Eckhart W, Friedmann T, Esty A, LaPorte P, Deininger P. Regions of the polyoma genome coding for T antigens. Nucleic Acids Research. 7: 2275-88. PMID 230465 DOI: 10.1093/Nar/7.8.2275 |
0.539 |
|
| 1979 |
Deininger P, Esty A, LaPorte P, Friedmann T. Nucleotide sequence and genetic organization of the polyoma late region: features common to the polyoma early region and SV40. Cell. 18: 771-9. PMID 229965 DOI: 10.1016/0092-8674(79)90130-2 |
0.553 |
|
| 1979 |
Friedmann T, Esty A, LaPorte P, Deininger P. The nucleotide sequence and genome organization of the polyoma early region: extensive nucleotide and amino acid homology with SV40. Cell. 17: 715-24. PMID 225042 DOI: 10.1016/0092-8674(79)90278-2 |
0.549 |
|
| 1978 |
Air GM, Coulson AR, Fiddes JC, Friedmann T, Hutchison CA, Sanger F, Slocombe PM, Smith AJ. Nucleotide sequence of the F protein coding region of bacteriophage phiX174 and the amino acid sequence of its product. Journal of Molecular Biology. 125: 247-54. PMID 731694 DOI: 10.1016/0022-2836(78)90347-9 |
0.551 |
|
| 1978 |
Sanger F, Coulson AR, Friedmann T, Air GM, Barrell BG, Brown NL, Fiddes JC, Hutchison CA, Slocombe PM, Smith M. The nucleotide sequence of bacteriophage phiX174. Journal of Molecular Biology. 125: 225-46. PMID 731693 DOI: 10.1016/0022-2836(78)90346-7 |
0.543 |
|
| 1976 |
Friedmann T. The future for gene therapy--a reevaluation. Annals of the New York Academy of Sciences. 265: 141-52. PMID 1066080 DOI: 10.1111/J.1749-6632.1976.Tb29328.X |
0.333 |
|
| 1972 |
Friedmann T, Roblin R. Gene therapy for human genetic disease? Science (New York, N.Y.). 175: 949-55. PMID 5061866 DOI: 10.1126/Science.175.4025.949 |
0.422 |
|
| 1969 |
Friedmann T, Seegmiller JE, Subak-Sharpe JH. Evidence against the existence of guanosine and inosine kinases in human fibroblasts in tissue culture. Experimental Cell Research. 56: 425-9. PMID 5824460 DOI: 10.1016/0014-4827(69)90034-2 |
0.477 |
|
| 1968 |
Seegmiller JE, Friedmann T, Harrison HE, Wong V, Schneider JA. Cystinosis. Combined clinical staff conference at the National Institutes of Health. Annals of Internal Medicine. 68: 883-905. PMID 5642970 |
0.375 |
|
| 1968 |
FRIEDMANN T, SEEGMILLER JE, SUBAK-SHARPE JH. Metabolic Cooperation between Genetically Marked Human Fibroblasts in Tissue Culture Nature. 220: 272-274. DOI: 10.1038/220272A0 |
0.514 |
|
| 1967 |
Friedmann T, Johnson P. The structure of Tamm-Horsfall mucoprotein in fibrocystic disease. The Journal of Laboratory and Clinical Medicine. 70: 404-7. PMID 4962588 |
0.425 |
|
| 1966 |
Friedmann T, Johnson P. Further characterization of the subunit of Tamm-Horsfall mucoprotein. Biochimica Et Biophysica Acta. 130: 355-60. PMID 5972848 DOI: 10.1016/0304-4165(66)90231-5 |
0.447 |
|
| 1966 |
Friedmann T, Johnson P. The disaggregation of Tamm Horsfall mucroprotein by acetic acid. Biochimica Et Biophysica Acta. 121: 292-7. PMID 4960255 DOI: 10.1016/0304-4165(66)90118-8 |
0.44 |
|
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