| Year |
Citation |
Score |
| 2020 |
Akgűn E, Lunzer MM, Tian D, Ansonoff M, Pintar J, Hawkinson JE, Wilcox GL, Portoghese P. FBNTI, a DOR-selective antagonist that allosterically activates MOR within a MOR-DOR heteromer. Biochemistry. PMID 32930576 DOI: 10.1021/Acs.Biochem.0C00498 |
0.516 |
|
| 2020 |
Speltz R, Lunzer MM, Shueb SS, Akgün E, Reed R, Kalyuzhny A, Portoghese PS, Simone DA. The bivalent ligand, MMG22, reduces neuropathic pain after nerve injury without the side effects of traditional opioids. Pain. PMID 32345918 DOI: 10.1097/J.Pain.0000000000001902 |
0.433 |
|
| 2019 |
Sheub SS, Erb SJ, Lunzer MM, Speltz R, Harding-Rose C, Akgün E, Simone DA, Portoghese PS. Targeting MOR-mGluR heteromers reduces bone cancer pain by activating MOR and inhibiting mGluR5. Neuropharmacology. 107690. PMID 31271770 DOI: 10.1016/J.Neuropharm.2019.107690 |
0.397 |
|
| 2019 |
Zhang X, Peng Y, Grace PM, Metcalf MD, Kwilasz AJ, Wang Y, Zhang T, Wu S, Selfridge BR, Portoghese PS, Rice KC, Watkins LR, Hutchinson MR, Wang X. Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201900173RRR. PMID 31162938 DOI: 10.1096/Fj.201900173Rrr |
0.35 |
|
| 2019 |
Cataldo G, Erb SJ, Lunzer MM, Luong N, Akgün E, Portoghese PS, Olson JK, Simone DA. The bivalent ligand MCC22 potently attenuates hyperalgesia in a mouse model of cisplatin-evoked neuropathic pain without tolerance or reward. Neuropharmacology. PMID 30970233 DOI: 10.1016/J.Neuropharm.2019.04.004 |
0.424 |
|
| 2019 |
Borsodi A, Bruchas M, Caló G, Chavkin C, Christie MJ, Civelli O, Connor M, Cox BM, Devi LA, Evans C, Höllt V, Henderson G, Husbands S, Kelly E, Kieffer B, ... ... Portoghese PS, et al. Opioid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f50/2019.4 |
0.513 |
|
| 2018 |
Akgün E, Lunzer MM, Portoghese PS. Combined Glia Inhibition and Opioid Receptor Agonism Afford Highly Potent Analgesics without Tolerance. Acs Chemical Neuroscience. PMID 30110531 DOI: 10.1021/Acschemneuro.8B00323 |
0.501 |
|
| 2018 |
Dutta R, Lunzer MM, Auger JL, Akgün E, Portoghese PS, Binstadt BA. A bivalent compound targeting CCR5 and the mu opioid receptor treats inflammatory arthritis pain in mice without inducing pharmacologic tolerance. Arthritis Research & Therapy. 20: 154. PMID 30053832 DOI: 10.1186/S13075-018-1661-5 |
0.58 |
|
| 2018 |
Cataldo G, Lunzer MM, Olson JK, Akgün E, Belcher JD, Vercellotti GM, Portoghese PS, Simone DA. The bivalent ligand MCC22 potently attenuates nociception in a murine model of sickle cell disease. Pain. PMID 29578946 DOI: 10.1097/J.Pain.0000000000001225 |
0.425 |
|
| 2017 |
Peterson CD, Kitto KF, Akgün E, Lunzer MM, Riedl MS, Vulchanova L, Wilcox GL, Portoghese PS, Fairbanks CA. A bivalent ligand that activates mu opioid receptor and antagonizes mGluR5 receptor reduces neuropathic pain in mice. Pain. PMID 28891868 DOI: 10.1097/J.Pain.0000000000001050 |
0.494 |
|
| 2017 |
Portoghese PS, Akgün E, Lunzer MM. Heteromer Induction: An Approach to Unique Pharmacology? Acs Chemical Neuroscience. PMID 28139906 DOI: 10.1021/Acschemneuro.7B00002 |
0.555 |
|
| 2016 |
Goudie-DeAngelis EM, Abdelhamid RE, Nunez MG, Kissel CL, Kovács KJ, Portoghese PS, Larson AA. Modulation of Musculoskeletal Hyperalgesia by Brown Adipose Tissue Activity in Mice. Pain. PMID 27437788 DOI: 10.1097/J.Pain.0000000000000677 |
0.315 |
|
| 2015 |
Akgün E, Javed MI, Lunzer MM, Powers MD, Sham YY, Watanabe Y, Portoghese PS. Inhibition of Inflammatory and Neuropathic Pain by Targeting a Mu Opioid Receptor/Chemokine Receptor5 Heteromer (MOR-CCR5). Journal of Medicinal Chemistry. PMID 26451468 DOI: 10.1021/Acs.Jmedchem.5B01245 |
0.556 |
|
| 2015 |
Cataldo G, Lunzer MM, Simone DA, Akgün E, Belcher JD, Vercellotti GM, Portoghese PS. Targeting Putative Mu Opioid/Chemokine Receptor Type 5 Heteromers Potently Attenuates Nociception in a Murine Model of Sickle Cell Disease Blood. 126: 277-277. DOI: 10.1182/Blood.V126.23.277.277 |
0.38 |
|
| 2014 |
Smeester BA, Lunzer MM, Akgün E, Beitz AJ, Portoghese PS. Targeting putative mu opioid/metabotropic glutamate receptor-5 heteromers produces potent antinociception in a chronic murine bone cancer model. European Journal of Pharmacology. 743: 48-52. PMID 25239072 DOI: 10.1016/J.Ejphar.2014.09.008 |
0.491 |
|
| 2014 |
Le Naour M, Lunzer MM, Powers MD, Kalyuzhny AE, Benneyworth MA, Thomas MJ, Portoghese PS. Putative kappa opioid heteromers as targets for developing analgesics free of adverse effects. Journal of Medicinal Chemistry. 57: 6383-92. PMID 24978316 DOI: 10.1021/Jm500159D |
0.491 |
|
| 2013 |
Akgün E, Javed MI, Lunzer MM, Smeester BA, Beitz AJ, Portoghese PS. Ligands that interact with putative MOR-mGluR5 heteromer in mice with inflammatory pain produce potent antinociception. Proceedings of the National Academy of Sciences of the United States of America. 110: 11595-9. PMID 23798416 DOI: 10.1073/Pnas.1305461110 |
0.523 |
|
| 2013 |
Le Naour M, Akgün E, Yekkirala A, Lunzer MM, Powers MD, Kalyuzhny AE, Portoghese PS. Bivalent ligands that target μ opioid (MOP) and cannabinoid1 (CB1) receptors are potent analgesics devoid of tolerance. Journal of Medicinal Chemistry. 56: 5505-13. PMID 23734559 DOI: 10.1021/Jm4005219 |
0.831 |
|
| 2013 |
Yekkirala AS, Kalyuzhny AE, Portoghese PS. An immunocytochemical-derived correlate for evaluating the bridging of heteromeric mu-delta opioid protomers by bivalent ligands. Acs Chemical Biology. 8: 1412-6. PMID 23675763 DOI: 10.1021/Cb400113D |
0.833 |
|
| 2013 |
Pravetoni M, Le Naour M, Tucker AM, Harmon TM, Hawley TM, Portoghese PS, Pentel PR. Reduced antinociception of opioids in rats and mice by vaccination with immunogens containing oxycodone and hydrocodone haptens. Journal of Medicinal Chemistry. 56: 915-23. PMID 23249238 DOI: 10.1021/Jm3013745 |
0.38 |
|
| 2012 |
Aceto MD, Harris LS, Negus SS, Banks ML, Hughes LD, Akgün E, Portoghese PS. MDAN-21: A Bivalent Opioid Ligand Containing mu-Agonist and Delta-Antagonist Pharmacophores and Its Effects in Rhesus Monkeys. International Journal of Medicinal Chemistry. 2012: 327257. PMID 25954526 DOI: 10.1155/2012/327257 |
0.495 |
|
| 2012 |
Yekkirala AS, Banks ML, Lunzer MM, Negus SS, Rice KC, Portoghese PS. Clinically employed opioid analgesics produce antinociception via μ-δ opioid receptor heteromers in Rhesus monkeys. Acs Chemical Neuroscience. 3: 720-7. PMID 23019498 DOI: 10.1021/Cn300049M |
0.84 |
|
| 2012 |
Metcalf MD, Yekkirala AS, Powers MD, Kitto KF, Fairbanks CA, Wilcox GL, Portoghese PS. The δ opioid receptor agonist SNC80 selectively activates heteromeric μ-δ opioid receptors. Acs Chemical Neuroscience. 3: 505-9. PMID 22860219 DOI: 10.1021/Cn3000394 |
0.843 |
|
| 2012 |
Pravetoni M, Raleigh MD, Le Naour M, Tucker AM, Harmon TM, Jones JM, Birnbaum AK, Portoghese PS, Pentel PR. Co-administration of morphine and oxycodone vaccines reduces the distribution of 6-monoacetylmorphine and oxycodone to brain in rats. Vaccine. 30: 4617-24. PMID 22583811 DOI: 10.1016/J.Vaccine.2012.04.101 |
0.352 |
|
| 2012 |
Cawston EE, Lam PC, Harikumar KG, Dong M, Ball AM, Augustine ML, Akgün E, Portoghese PS, Orry A, Abagyan R, Sexton PM, Miller LJ. Molecular basis for binding and subtype selectivity of 1,4-benzodiazepine antagonist ligands of the cholecystokinin receptor. The Journal of Biological Chemistry. 287: 18618-35. PMID 22467877 DOI: 10.1074/Jbc.M111.335646 |
0.431 |
|
| 2012 |
Pravetoni M, Le Naour M, Harmon TM, Tucker AM, Portoghese PS, Pentel PR. An oxycodone conjugate vaccine elicits drug-specific antibodies that reduce oxycodone distribution to brain and hot-plate analgesia. The Journal of Pharmacology and Experimental Therapeutics. 341: 225-32. PMID 22262924 DOI: 10.1124/Jpet.111.189506 |
0.376 |
|
| 2012 |
Le Naour M, Lunzer MM, Powers MD, Portoghese PS. Opioid activity of spinally selective analogues of N-naphthoyl-β-naltrexamine in HEK-293 cells and mice. Journal of Medicinal Chemistry. 55: 670-7. PMID 22136373 DOI: 10.1021/Jm200902V |
0.575 |
|
| 2012 |
Berg KA, Rowan MP, Gupta A, Sanchez TA, Silva M, Gomes I, McGuire BA, Portoghese PS, Hargreaves KM, Devi LA, Clarke WP. Allosteric interactions between δ and κ opioid receptors in peripheral sensory neurons. Molecular Pharmacology. 81: 264-72. PMID 22072818 DOI: 10.1124/Mol.111.072702 |
0.499 |
|
| 2011 |
Tang Y, Yang J, Lunzer MM, Powers MD, Portoghese PS. A κ Opioid Pharmacophore Becomes a Spinally Selective κ-δ Agonist When Modified with a Basic Extender Arm. Acs Medicinal Chemistry Letters. 2: 7-10. PMID 24936231 DOI: 10.1021/Ml1001294 |
0.538 |
|
| 2011 |
Yekkirala AS, Lunzer MM, McCurdy CR, Powers MD, Kalyuzhny AE, Roerig SC, Portoghese PS. N-naphthoyl-beta-naltrexamine (NNTA), a highly selective and potent activator of μ/kappa-opioid heteromers. Proceedings of the National Academy of Sciences of the United States of America. 108: 5098-103. PMID 21385944 DOI: 10.1073/Pnas.1016277108 |
0.843 |
|
| 2010 |
Yekkirala AS, Kalyuzhny AE, Portoghese PS. Standard opioid agonists activate heteromeric opioid receptors: evidence for morphine and [d-Ala(2)-MePhe(4)-Glyol(5)]enkephalin as selective μ-δ agonists. Acs Chemical Neuroscience. 1: 146-54. PMID 22816017 DOI: 10.1021/Cn9000236 |
0.844 |
|
| 2010 |
Ansonoff MA, Portoghese PS, Pintar JE. Consequences of opioid receptor mutation on actions of univalent and bivalent kappa and delta ligands. Psychopharmacology. 210: 161-8. PMID 20333506 DOI: 10.1007/S00213-010-1826-7 |
0.589 |
|
| 2010 |
Harikumar KG, Akgün E, Portoghese PS, Miller LJ. Modulation of cell surface expression of nonactivated cholecystokinin receptors using bivalent ligand-induced internalization. Journal of Medicinal Chemistry. 53: 2836-42. PMID 20235611 DOI: 10.1021/Jm100135G |
0.479 |
|
| 2010 |
Harikumar KG, Akgün E, Portoghese PS, Miller L. Internalization of Two Distinct Receptors in Response to Occupation with a Bivalent Ligand Incorporating a Single Stimulus for Internalization Biophysical Journal. 98: 501a. DOI: 10.1016/J.Bpj.2009.12.2728 |
0.496 |
|
| 2009 |
Zhang S, Yekkirala A, Tang Y, Portoghese PS. A bivalent ligand (KMN-21) antagonist for mu/kappa heterodimeric opioid receptors. Bioorganic & Medicinal Chemistry Letters. 19: 6978-80. PMID 19892550 DOI: 10.1016/J.Bmcl.2009.10.045 |
0.841 |
|
| 2009 |
Akgün E, Körner M, Gao F, Harikumar KG, Waser B, Reubi JC, Portoghese PS, Miller LJ. Synthesis and in vitro characterization of radioiodinatable benzodiazepines selective for type 1 and type 2 cholecystokinin receptors. Journal of Medicinal Chemistry. 52: 2138-47. PMID 19271701 DOI: 10.1021/Jm801439X |
0.467 |
|
| 2009 |
Zheng Y, Akgün E, Harikumar KG, Hopson J, Powers MD, Lunzer MM, Miller LJ, Portoghese PS. Induced association of mu opioid (MOP) and type 2 cholecystokinin (CCK2) receptors by novel bivalent ligands. Journal of Medicinal Chemistry. 52: 247-58. PMID 19113864 DOI: 10.1021/Jm800174P |
0.58 |
|
| 2008 |
Rady JJ, Holmes BB, Portoghese PS, Fujimoto JM. Morphine Tolerance in Mice Changes Response of Heroin from μ to δ Opioid Receptors Proceedings of the Society For Experimental Biology and Medicine. 224: 93-101. DOI: 10.1111/j.1525-1373.2000.22406.x |
0.46 |
|
| 2007 |
Haris SP, Zhang Y, Le Bourdonnec B, McCurdy CR, Portoghese PS. o-Naphthalenedicarboxaldehyde derivative of 7'-aminonaltrindole as a selective delta-opioid receptor affinity label. Journal of Medicinal Chemistry. 50: 3392-6. PMID 17555306 DOI: 10.1021/Jm061194H |
0.507 |
|
| 2007 |
Lunzer MM, Portoghese PS. Selectivity of delta- and kappa-opioid ligands depends on the route of central administration in mice. The Journal of Pharmacology and Experimental Therapeutics. 322: 166-71. PMID 17400888 DOI: 10.1124/Jpet.107.120279 |
0.589 |
|
| 2007 |
Lunzer MM, Yekkirala A, Hebbel RP, Portoghese PS. Naloxone acts as a potent analgesic in transgenic mouse models of sickle cell anemia. Proceedings of the National Academy of Sciences of the United States of America. 104: 6061-5. PMID 17389363 DOI: 10.1073/Pnas.0700295104 |
0.815 |
|
| 2007 |
Lenard NR, Daniels DJ, Portoghese PS, Roerig SC. Absence of conditioned place preference or reinstatement with bivalent ligands containing mu-opioid receptor agonist and delta-opioid receptor antagonist pharmacophores. European Journal of Pharmacology. 566: 75-82. PMID 17383633 DOI: 10.1016/J.Ejphar.2007.02.040 |
0.611 |
|
| 2007 |
Akgün E, Portoghese PS, Sajjad M, Nabi HA. Synthesis and 124I-labeling of m-iodophenylpyrrolomorphinan as a potential PET imaging agent for delta opioid (DOP) receptors Journal of Labelled Compounds and Radiopharmaceuticals. 50: 165-170. DOI: 10.1002/Jlcr.1216 |
0.422 |
|
| 2006 |
Akgün E, Sajjad M, Portoghese PS. N1'-(p-[18F]fluorobenzyl)naltrindole (p-[18F]BNTI) as a potential PET imaging agent for DOP receptors Journal of Labelled Compounds and Radiopharmaceuticals. 49: 857-866. DOI: 10.1002/Jlcr.1095 |
0.422 |
|
| 2005 |
Daniels DJ, Lenard NR, Etienne CL, Law PY, Roerig SC, Portoghese PS. Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series. Proceedings of the National Academy of Sciences of the United States of America. 102: 19208-13. PMID 16365317 DOI: 10.1073/Pnas.0506627102 |
0.596 |
|
| 2005 |
Xie Z, Bhushan RG, Daniels DJ, Portoghese PS. Interaction of bivalent ligand KDN21 with heterodimeric delta-kappa opioid receptors in human embryonic kidney 293 cells. Molecular Pharmacology. 68: 1079-86. PMID 16006595 DOI: 10.1124/Mol.105.012070 |
0.605 |
|
| 2005 |
Waldhoer M, Fong J, Jones RM, Lunzer MM, Sharma SK, Kostenis E, Portoghese PS, Whistler JL. A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers. Proceedings of the National Academy of Sciences of the United States of America. 102: 9050-5. PMID 15932946 DOI: 10.1073/Pnas.0501112102 |
0.678 |
|
| 2005 |
Zhang Y, Sham YY, Rajamani R, Gao J, Portoghese PS. Homology modeling and molecular dynamics simulations of the mu opioid receptor in a membrane-aqueous system. Chembiochem : a European Journal of Chemical Biology. 6: 853-9. PMID 15776407 DOI: 10.1002/Cbic.200400207 |
0.541 |
|
| 2005 |
Daniels DJ, Kulkarni A, Xie Z, Bhushan RG, Portoghese PS. A bivalent ligand (KDAN-18) containing delta-antagonist and kappa-agonist pharmacophores bridges delta2 and kappa1 opioid receptor phenotypes. Journal of Medicinal Chemistry. 48: 1713-6. PMID 15771416 DOI: 10.1021/Jm034234F |
0.613 |
|
| 2005 |
Zhang Y, McCurdy CR, Metzger TG, Portoghese PS. Specific cross-linking of Lys233 and Cys235 in the mu opioid receptor by a reporter affinity label. Biochemistry. 44: 2271-5. PMID 15709739 DOI: 10.1021/Bi048049V |
0.561 |
|
| 2005 |
Jutkiewicz EM, Walker NP, Folk JE, Rice KC, Portoghese PS, Woods JH, Traynor JR. Comparison of peptidic and nonpeptidic delta-opioid agonists on guanosine 5'-O-(3-[35S]thio)triphosphate ([35S]GTPgammaS) binding in brain slices from Sprague-Dawley rats. The Journal of Pharmacology and Experimental Therapeutics. 312: 1314-20. PMID 15574687 DOI: 10.1124/Jpet.104.078741 |
0.52 |
|
| 2004 |
Bhushan RG, Sharma SK, Xie Z, Daniels DJ, Portoghese PS. A bivalent ligand (KDN-21) reveals spinal delta and kappa opioid receptors are organized as heterodimers that give rise to delta(1) and kappa(2) phenotypes. Selective targeting of delta-kappa heterodimers. Journal of Medicinal Chemistry. 47: 2969-72. PMID 15163177 DOI: 10.1021/Jm0342358 |
0.554 |
|
| 2004 |
Todtenkopf MS, Marcus JF, Portoghese PS, Carlezon WA. Effects of kappa-opioid receptor ligands on intracranial self-stimulation in rats. Psychopharmacology. 172: 463-70. PMID 14727002 DOI: 10.1007/S00213-003-1680-Y |
0.431 |
|
| 2004 |
Townsend D, Portoghese PS, Brown DR. Characterization of specific opioid binding sites in neural membranes from the myenteric plexus of porcine small intestine. The Journal of Pharmacology and Experimental Therapeutics. 308: 385-93. PMID 14569065 DOI: 10.1124/Jpet.103.058016 |
0.425 |
|
| 2003 |
Portoghese PS, Law PY, Loh HH. Effect of opioid receptor ligands on the mu-S196A knock-in and mu knockout mouse vas deferens. European Journal of Pharmacology. 478: 207-10. PMID 14575806 DOI: 10.1016/J.Ejphar.2003.08.041 |
0.605 |
|
| 2003 |
Portoghese PS, Lunzer MM. Identity of the putative delta1-opioid receptor as a delta-kappa heteromer in the mouse spinal cord. European Journal of Pharmacology. 467: 233-4. PMID 12706480 DOI: 10.1016/S0014-2999(03)01599-1 |
0.561 |
|
| 2003 |
Mague SD, Pliakas AM, Todtenkopf MS, Tomasiewicz HC, Zhang Y, Stevens WC, Jones RM, Portoghese PS, Carlezon WA. Antidepressant-like effects of kappa-opioid receptor antagonists in the forced swim test in rats. The Journal of Pharmacology and Experimental Therapeutics. 305: 323-30. PMID 12649385 DOI: 10.1124/Jpet.102.046433 |
0.644 |
|
| 2002 |
Negus SS, Mello NK, Linsenmayer DC, Jones RM, Portoghese PS. Kappa opioid antagonist effects of the novel kappa antagonist 5'-guanidinonaltrindole (GNTI) in an assay of schedule-controlled behavior in rhesus monkeys. Psychopharmacology. 163: 412-9. PMID 12373442 DOI: 10.1007/S00213-002-1038-X |
0.686 |
|
| 2002 |
McCurdy CR, Le Bourdonnec B, Metzger TG, El Kouhen R, Zhang Y, Law PY, Portoghese PS. Naphthalene dicarboxaldehyde as an electrophilic fluorogenic moiety for affinity labeling: application to opioid receptor affinity labels with greatly improved fluorogenic properties. Journal of Medicinal Chemistry. 45: 2887-90. PMID 12086475 DOI: 10.1021/Jm015586U |
0.562 |
|
| 2002 |
Rady JJ, Portoghese PS, Fujimo JM. Methadone and heroin antinociception: predominant delta-opioid-receptor responses in methadone-tolerant mice. Japanese Journal of Pharmacology. 88: 319-31. PMID 11949888 DOI: 10.1254/Jjp.88.319 |
0.576 |
|
| 2001 |
Jewett DC, Grace MK, Jones RM, Billington CJ, Portoghese PS, Levine AS. The kappa-opioid antagonist GNTI reduces U50,488-, DAMGO-, and deprivation-induced feeding, but not butorphanol- and neuropeptide Y-induced feeding in rats. Brain Research. 909: 75-80. PMID 11478923 DOI: 10.1016/S0006-8993(01)02624-5 |
0.663 |
|
| 2001 |
Portoghese PS. From models to molecules: opioid receptor dimers, bivalent ligands, and selective opioid receptor probes. Journal of Medicinal Chemistry. 44: 2259-69. PMID 11428919 DOI: 10.1021/Jm010158+ |
0.593 |
|
| 2001 |
Portoghese PS, el Kouhen R, Law PY, Loh HH, Le Bourdonnec B. Affinity labels as tools for the identification of opioid receptor recognition sites. Farmaco (Societã Chimica Italiana : 1989). 56: 191-6. PMID 11409326 DOI: 10.1016/S0014-827X(01)01040-0 |
0.575 |
|
| 2001 |
Sharma SK, Jones RM, Metzger TG, Ferguson DM, Portoghese PS. Transformation of a kappa-opioid receptor antagonist to a kappa-agonist by transfer of a guanidinium group from the 5'- to 6'-position of naltrindole. Journal of Medicinal Chemistry. 44: 2073-9. PMID 11405645 DOI: 10.1021/Jm010095V |
0.68 |
|
| 2001 |
Poonyachoti S, Portoghese PS, Brown DR. Pharmacological evidence for a 7-benzylidenenaltrexone-preferring opioid receptor mediating the inhibitory actions of peptidic delta- and mu-opioid agonists on neurogenic ion transport in porcine ileal mucosa. The Journal of Pharmacology and Experimental Therapeutics. 297: 672-9. PMID 11303057 |
0.481 |
|
| 2001 |
Peterson PK, Gekker G, Lokensgard JR, Bidlack JM, Chang AC, Fang X, Portoghese PS. Kappa-opioid receptor agonist suppression of HIV-1 expression in CD4+ lymphocytes. Biochemical Pharmacology. 61: 1145-51. PMID 11301048 DOI: 10.1016/S0006-2952(01)00574-3 |
0.378 |
|
| 2001 |
Metzger TG, Paterlini MG, Ferguson DM, Portoghese PS. Investigation of the selectivity of oxymorphone- and naltrexone-derived ligands via site-directed mutagenesis of opioid receptors: exploring the "address" recognition locus. Journal of Medicinal Chemistry. 44: 857-62. PMID 11300867 DOI: 10.1021/jm000381r |
0.519 |
|
| 2001 |
Le Bourdonnec B, El Kouhen R, Poda G, Law PY, Loh HH, Ferguson DM, Portoghese PS. Covalently induced activation of the delta opioid receptor by a fluorogenic affinity label, 7'-(phthalaldehydecarboxamido)naltrindole (PNTI). Journal of Medicinal Chemistry. 44: 1017-20. PMID 11297446 DOI: 10.1021/Jm010004U |
0.578 |
|
| 2001 |
Poonyachoti S, Portoghese PS, Brown DR. Characterization of opioid receptors modulating neurogenic contractions of circular muscle from porcine ileum and evidence that delta- and kappa-opioid receptors are coexpressed in myenteric neurons. The Journal of Pharmacology and Experimental Therapeutics. 297: 69-77. PMID 11259529 |
0.476 |
|
| 2001 |
Portoghese PS. Molecular recognition at kappa opioid receptors Pure and Applied Chemistry. 73: 1387-1391. DOI: 10.1351/Pac200173091387 |
0.554 |
|
| 2001 |
Portoghese PS. 2000 Alfred Burger Award Address in Medicinal Chemistry. From Models to Molecules: Opioid Receptor Dimers, Bivalent Ligands, and Selective Opioid Receptor Probes. Journal of Medicinal Chemistry. 44: 3758-3758. DOI: 10.1021/Jm0103514 |
0.593 |
|
| 2000 |
Stevens WC, Jones RM, Subramanian G, Metzger TG, Ferguson DM, Portoghese PS. Potent and selective indolomorphinan antagonists of the kappa-opioid receptor. Journal of Medicinal Chemistry. 43: 2759-69. PMID 10893314 DOI: 10.1021/Jm0000665 |
0.705 |
|
| 2000 |
Le Bourdonnec B, El Kouhen R, Lunzer MM, Law PY, Loh HH, Portoghese PS. Reporter affinity labels: an o-phthalaldehyde derivative of beta-naltrexamine as a fluorogenic ligand for opioid receptors. Journal of Medicinal Chemistry. 43: 2489-92. PMID 10891107 DOI: 10.1021/Jm000138S |
0.502 |
|
| 2000 |
Jones RM, Portoghese PS. 5'-Guanidinonaltrindole, a highly selective and potent kappa-opioid receptor antagonist. European Journal of Pharmacology. 396: 49-52. PMID 10822054 DOI: 10.1016/S0014-2999(00)00208-9 |
0.698 |
|
| 2000 |
Rady JJ, Holmes BB, Portoghese PS, Fujimoto JM. Morphine tolerance in mice changes response of heroin from mu to delta opioid receptors. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 224: 93-101. PMID 10806416 |
0.499 |
|
| 2000 |
Larson DL, Jones RM, Hjorth SA, Schwartz TW, Portoghese PS. Binding of norbinaltorphimine (norBNI) congeners to wild-type and mutant mu and kappa opioid receptors: molecular recognition loci for the pharmacophore and address components of kappa antagonists. Journal of Medicinal Chemistry. 43: 1573-6. PMID 10780914 DOI: 10.1021/Jm000059G |
0.687 |
|
| 2000 |
McCurdy CR, Jones RM, Portoghese PS. Investigation of phenolic bioisosterism in opiates: 3-sulfonamido analogues of naltrexone and oxymorphone. Organic Letters. 2: 819-21. PMID 10754685 DOI: 10.1021/Ol005561+ |
0.57 |
|
| 2000 |
Ferguson DM, Kramer S, Metzger TG, Law PY, Portoghese PS. Isosteric replacement of acidic with neutral residues in extracellular loop-2 of the kappa-opioid receptor does not affect dynorphin A(1-13) affinity and function. Journal of Medicinal Chemistry. 43: 1251-2. PMID 10753461 DOI: 10.1021/Jm990583R |
0.547 |
|
| 2000 |
Subramanian G, Paterlini MG, Portoghese PS, Ferguson DM. Molecular docking reveals a novel binding site model for fentanyl at the mu-opioid receptor. Journal of Medicinal Chemistry. 43: 381-91. PMID 10669565 DOI: 10.1021/Jm9903702 |
0.497 |
|
| 2000 |
Paterlini MG, Avitabile F, Ostrowski BG, Ferguson DM, Portoghese PS. Stereochemical requirements for receptor recognition of the mu-opioid peptide endomorphin-1. Biophysical Journal. 78: 590-9. PMID 10653774 DOI: 10.1016/S0006-3495(00)76619-7 |
0.397 |
|
| 1999 |
June HL, McCane SR, Zink RW, Portoghese PS, Li TK, Froehlich JC. The delta 2-opioid receptor antagonist naltriben reduces motivated responding for ethanol. Psychopharmacology. 147: 81-9. PMID 10591872 DOI: 10.1007/S002130051145 |
0.303 |
|
| 1999 |
Peterson PK, Gekker G, Hu S, Lokensgard J, Portoghese PS, Chao CC. Endomorphin-1 potentiates HIV-1 expression in human brain cell cultures: implication of an atypical mu-opioid receptor. Neuropharmacology. 38: 273-8. PMID 10218868 DOI: 10.1016/S0028-3908(98)00167-1 |
0.543 |
|
| 1998 |
PORTOGHESE PS. The absolute antipodal activity of analgesics in the basic anilide series. Journal of Pharmaceutical Sciences. 51: 1197-8. PMID 13985627 DOI: 10.1002/Jps.2600511221 |
0.324 |
|
| 1998 |
Jones RM, Hjorth SA, Schwartz TW, Portoghese PS. Mutational evidence for a common kappa antagonist binding pocket in the wild-type kappa and mutant mu[K303E] opioid receptors. Journal of Medicinal Chemistry. 41: 4911-4. PMID 9836606 DOI: 10.1021/Jm9805182 |
0.653 |
|
| 1998 |
Subramanian G, Germana Paterlini M, Larson DL, Portoghese PS, Ferguson DM. Conformational analysis and automated receptor docking of selective arylacetamide-based κ-opioid agonists Journal of Medicinal Chemistry. 41: 4777-4789. PMID 9822548 DOI: 10.1021/Jm9803166 |
0.473 |
|
| 1998 |
Ohkawa S, Portoghese PS. 7-Arylidenenaltrexones as selective delta1 opioid receptor antagonists. Journal of Medicinal Chemistry. 41: 4177-80. PMID 9767654 DOI: 10.1021/Jm980384S |
0.528 |
|
| 1998 |
Linner KM, Stickney BJ, Quist HE, Sharp BM, Portoghese PS. The delta1-opioid receptor antagonist, 7-(benzospiroindanyl)naltrexone [correction of 7-benzylspiroindanylnaltrexone], prolongs renal allograft survival in a rat model. European Journal of Pharmacology. 354: R3-5. PMID 9726640 DOI: 10.1016/S0014-2999(98)00477-4 |
0.517 |
|
| 1998 |
Gao P, Larson DL, Portoghese PS. Synthesis of 7-arylmorphinans. Probing the 'address' requirements for selectivity at opioid δ receptors Journal of Medicinal Chemistry. 41: 3091-3098. PMID 9685249 DOI: 10.1021/Jm9802214 |
0.611 |
|
| 1998 |
Kshirsagar T, Nakano AH, Law PY, Elde R, Portoghese PS. NTI4F: a non-peptide fluorescent probe selective for functional delta opioid receptors. Neuroscience Letters. 249: 83-6. PMID 9682822 DOI: 10.1016/S0304-3940(98)00379-6 |
0.583 |
|
| 1998 |
Kshirsagar TA, Fang X, Portoghese PS. 14-Desoxy analogues of naltrindole and 7-spiroindanyloxymorphone: the role of the 14-hydroxy group at delta opioid receptors. Journal of Medicinal Chemistry. 41: 2657-60. PMID 9651172 DOI: 10.1021/Jm980209B |
0.571 |
|
| 1998 |
Krishnan-Sarin S, Wand GS, Li XW, Portoghese PS, Froehlich JC. Effect of mu opioid receptor blockade on alcohol intake in rats bred for high alcohol drinking. Pharmacology, Biochemistry, and Behavior. 59: 627-35. PMID 9512064 DOI: 10.1016/S0091-3057(97)00474-7 |
0.303 |
|
| 1998 |
Linner KM, Stickney BJ, Quist HE, Sharp BM, Portoghese PS. Erratum: The σ1-opioid receptor antagonist, 7-benzylspiroindanylnaltrexone, prolongs renal allograft survival in a rat model (European Journal of Pharmacology 354 (1998) (R3-R5) PII: S0014299998004774) European Journal of Pharmacology. 363. DOI: 10.1016/S0014-2999(98)00776-6 |
0.412 |
|
| 1997 |
Paterlini G, Portoghese PS, Ferguson DM. Molecular simulation of dynorphin A-(1-10) binding to extracellular loop 2 of the kappa-opioid receptor. A model for receptor activation. Journal of Medicinal Chemistry. 40: 3254-62. PMID 9379445 DOI: 10.1021/Jm970252J |
0.539 |
|
| 1997 |
Clark MJ, Emmerson PJ, Mansour A, Akil H, Woods JH, Portoghese PS, Remmers AE, Medzihradsky F. Opioid efficacy in a C6 glioma cell line stably expressing the delta opioid receptor. The Journal of Pharmacology and Experimental Therapeutics. 283: 501-10. PMID 9353363 |
0.46 |
|
| 1997 |
Fang X, Larson DL, Portoghese PS. 7-Spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands Journal of Medicinal Chemistry. 40: 3064-3070. PMID 9301669 DOI: 10.1021/Jm970283E |
0.599 |
|
| 1997 |
Farouz-Grant F, Portoghese PS. Pyrrolomorphinans as delta opioid receptor antagonists. The role of steric hindrance in conferring selectivity. Journal of Medicinal Chemistry. 40: 1977-81. PMID 9207938 DOI: 10.1021/jm970189y |
0.483 |
|
| 1997 |
Ohkawa S, DiGiacomo B, Larson DL, Takemori AE, Portoghese PS. 7-Spiroindanyl derivatives of naltrexone and oxymorphone as selective ligands for delta opioid receptors. Journal of Medicinal Chemistry. 40: 1720-5. PMID 9171881 DOI: 10.1021/jm9700880 |
0.543 |
|
| 1997 |
Schwartz RW, Chang AC, Portoghese PS, Berzetei-Gurske IP. A guinea pig ileum preparation devoid of functional kappa receptors: a new in vitro pharmacologic assay for mu-opioid ligands. Life Sciences. 60: PL235-9. PMID 9096250 DOI: 10.1016/S0024-3205(97)00076-3 |
0.609 |
|
| 1997 |
Rady JJ, Baemmert D, Takemori AE, Portoghese PS, Fujimoto JM. Spinal delta opioid receptor subtype activity of 6-monoacetylmorphine in Swiss Webster mice. Pharmacology, Biochemistry, and Behavior. 56: 243-9. PMID 9050081 DOI: 10.1016/S0091-3057(96)00219-5 |
0.573 |
|
| 1997 |
Korlipara V, Ells J, Wang J, Tam S, Elde R, Portoghese P. Fluorescent N-benzylnaltrindole analogues as potential delta opioid receptor selective probes European Journal of Medicinal Chemistry. 32: 171-174. DOI: 10.1016/S0223-5234(97)87545-9 |
0.521 |
|
| 1996 |
Dhawan BN, Cesselin F, Raghubir R, Reisine T, Bradley PB, Portoghese PS, Hamon M. International Union of Pharmacology. XII. Classification of opioid receptors. Pharmacological Reviews. 48: 567-92. PMID 8981566 |
0.497 |
|
| 1996 |
Metzger TG, Paterlini MG, Portoghese PS, Ferguson DM. Application of the message-address concept to the docking of naltrexone and selective naltrexone-derived opioid antagonists into opioid receptor models. Neurochemical Research. 21: 1287-94. PMID 8947918 DOI: 10.1007/Bf02532369 |
0.584 |
|
| 1996 |
Chang AC, Cowan A, Takemori AE, Portoghese PS. Aspartic acid conjugates of 2-(3,4-dichlorophenyl)-N-methyl-N-[(1S)-1(3-aminophenyl)-2-(1-pyrrolidi nyl) ethyl]acetamide: kappa opioid receptor agonists with limited access to the central nervous system. Journal of Medicinal Chemistry. 39: 4478-82. PMID 8893842 DOI: 10.1021/Jm960459X |
0.498 |
|
| 1996 |
Chang AC, Chao CC, Takemori AE, Gekker G, Hu S, Peterson PK, Portoghese PS. Arylacetamide-derived fluorescent probes: synthesis, biological evaluation, and direct fluorescent labeling of kappa opioid receptors in mouse microglial cells. Journal of Medicinal Chemistry. 39: 1729-35. PMID 8648612 DOI: 10.1021/Jm950813B |
0.508 |
|
| 1996 |
Bolognesi ML, Ojala WH, Gleason WB, Griffin JF, Farouz-Grant F, Larson DL, Takemori AE, Portoghese PS. Opioid antagonist activity of naltrexone-derived bivalent ligands: importance of a properly oriented molecular scaffold to guide "address" recognition at kappa opioid receptors. Journal of Medicinal Chemistry. 39: 1816-22. PMID 8627605 DOI: 10.1021/Jm950807F |
0.746 |
|
| 1996 |
Portoghese PS. Selective nonpeptide ligands as probes to explore δ opioid receptor architecture Pharmacochemistry Library. 24: 303-312. DOI: 10.1016/S0165-7208(96)80024-9 |
0.489 |
|
| 1996 |
Paterlini MG, Metzger TG, Portoghese PS, Ferguson DM. Identification of Helical Packing Motifs Common to Bacteriorhodopsin and G Protein-Coupled Receptors Journal of Molecular Modeling. 3: 70. DOI: 10.1007/S008940050024 |
0.377 |
|
| 1995 |
Portoghese PS, Farouz-Grant F, Sultana M, Takemori AE. 7'-Substituted amino acid conjugates of naltrindole. Hydrophilic groups as determinants of selective antagonism of delta 1 opioid receptor-mediated antinociception in mice. Journal of Medicinal Chemistry. 38: 402-7. PMID 7853332 DOI: 10.1021/Jm00003A002 |
0.565 |
|
| 1995 |
Korlipara VL, Takemori AE, Portoghese PS. Electrophilic N-benzylnaltrindoles as delta opioid receptor-selective antagonists. Journal of Medicinal Chemistry. 38: 1337-43. PMID 7731019 DOI: 10.1021/Jm00008A012 |
0.566 |
|
| 1995 |
Chao CC, Gekker G, Hu S, Sheng WS, Portoghese PS, Peterson PK. Upregulation of HIV-1 expression in cocultures of chronically infected promonocytes and human brain cells by dynorphin Biochemical Pharmacology. 50: 715-722. PMID 7669075 DOI: 10.1016/0006-2952(95)00176-Z |
0.344 |
|
| 1995 |
Chao CC, Gekker G, Sheng WS, Hu S, Portoghese PS, Peterson PK. Endogenous opioid peptides suppress cytokine-mediated upregulation of HIV- 1 expression in the chronically infected promonocyte clone U1 Advances in Experimental Medicine and Biology. 373: 65-72. PMID 7668162 DOI: 10.1007/978-1-4615-1951-5_10 |
0.449 |
|
| 1995 |
Killian P, Holmes BB, Takemori AE, Portoghese PS, Fujimoto JM. Cold water swim stress- and delta-2 opioid-induced analgesia are modulated by spinal gamma-aminobutyric acidA receptors. The Journal of Pharmacology and Experimental Therapeutics. 274: 730-4. PMID 7636735 |
0.406 |
|
| 1995 |
Krishnan-Sarin S, Portoghese PS, Li TK, Froehlich JC. The delta 2-opioid receptor antagonist naltriben selectively attenuates alcohol intake in rats bred for alcohol preference. Pharmacology, Biochemistry, and Behavior. 52: 153-9. PMID 7501658 DOI: 10.1016/0091-3057(95)00080-G |
0.44 |
|
| 1995 |
Tseng LF, Tsai JHH, Collins KA, Portoghese PS. Spinal δ2-, but not δ1-, μ-, or κ-opioid receptors are involved in the tail-flick inhibition induced by β-endorphin from nucleus raphe obscurus in the pentobarbital-anesthetized rat European Journal of Pharmacology. 277: 251-256. PMID 7493616 DOI: 10.1016/0014-2999(95)00084-X |
0.531 |
|
| 1995 |
Chang AC, Trometer JD, Portoghese PS. Synthesis of [3H]DIPPA: A potent irreversible antagonist selective for the κ opioid receptor Journal of Labelled Compounds and Radiopharmaceuticals. 36: 553-557. DOI: 10.1002/Jlcr.2580360607 |
0.587 |
|
| 1994 |
Búzás B, Izenwasser S, Portoghese PS, Cox BM. Evidence for delta opioid receptor subtypes regulating adenylyl cyclase activity in rat brain. Life Sciences. 54: PL101-6. PMID 8309345 DOI: 10.1016/0024-3205(94)00412-9 |
0.591 |
|
| 1994 |
Chang AC, Takemori AE, Portoghese PS. 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long-lasting kappa antagonism in mice. Journal of Medicinal Chemistry. 37: 1547-9. PMID 8201586 DOI: 10.1021/Jm00037A001 |
0.503 |
|
| 1994 |
Portoghese PS, Lin CE, Farouz-Grant F, Takemori AE. Structure-activity relationship of N17'-substituted norbinaltorphimine congeners. Role of the N17' basic group in the interaction with a putative address subsite on the kappa opioid receptor. Journal of Medicinal Chemistry. 37: 1495-500. PMID 8182708 DOI: 10.1021/Jm00036A015 |
0.505 |
|
| 1994 |
Levine AS, Grace M, Portoghese PS, Billington CJ. The effect of selective opioid antagonists on butorphanol-induced feeding. Brain Research. 637: 242-8. PMID 8180802 DOI: 10.1016/0006-8993(94)91239-4 |
0.45 |
|
| 1994 |
Vanderah T, Takemori AE, Sultana M, Portoghese PS, Mosberg HI, Hruby VJ, Haaseth RC, Matsunaga TO, Porreca F. Interaction of [D-Pen2,D-Pen5]enkephalin and [D-Ala2,Glu4]deltorphin with delta-opioid receptor subtypes in vivo. European Journal of Pharmacology. 252: 133-7. PMID 8157053 DOI: 10.1016/0014-2999(94)90588-6 |
0.568 |
|
| 1994 |
Portoghese PS, Sultana M, Moe ST, Takemori AE. Synthesis of naltrexone-derived delta-opioid antagonists. Role of conformation of the delta address moiety. Journal of Medicinal Chemistry. 37: 579-85. PMID 8126697 DOI: 10.1021/Jm00031A006 |
0.609 |
|
| 1994 |
Peterson PK, Gekker G, Hu S, Anderson WR, Kravitz F, Portoghese PS, Balfour HH, Chao CC. Morphine amplifies HIV-1 expression in chronically infected promonocytes cocultured with human brain cells. Journal of Neuroimmunology. 50: 167-75. PMID 8120138 DOI: 10.1016/0165-5728(94)90043-4 |
0.363 |
|
| 1994 |
Rady JJ, Takemori AE, Portoghese PS, Fujimoto JM. Supraspinal delta receptor subtype activity of heroin and 6-monoacetylmorphine in Swiss Webster mice. Life Sciences. 55: 603-9. PMID 8046996 DOI: 10.1016/0024-3205(94)00486-2 |
0.571 |
|
| 1994 |
Miyamoto Y, Bowen WD, Portoghese PS, Takemori AE. Lack of involvement of delta-1 opioid receptors in the development of physical dependence on morphine in mice. The Journal of Pharmacology and Experimental Therapeutics. 270: 37-9. PMID 8035333 |
0.506 |
|
| 1994 |
Portoghese PS, Ohkawa S, Moe ST, Takemori AE. Synthesis and delta-opioid receptor antagonist activity of a naltrindole analogue with a regioisomeric indole moiety. Journal of Medicinal Chemistry. 37: 1886-8. PMID 8021929 DOI: 10.1021/Jm00038A019 |
0.582 |
|
| 1994 |
Korlipara VL, Takemori AE, Portoghese PS. N-benzylnaltrindoles as long-acting delta-opioid receptor antagonists. Journal of Medicinal Chemistry. 37: 1882-5. PMID 8021928 DOI: 10.1021/Jm00038A018 |
0.612 |
|
| 1994 |
Chang AC, Takemori AE, Ojala WH, Gleason WB, Portoghese PS. kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists. Journal of Medicinal Chemistry. 37: 4490-8. PMID 7799399 DOI: 10.1021/Jm00052A008 |
0.579 |
|
| 1994 |
Chang AC, Takemori AE, Portoghese PS. DIPPA: An opioid receptor affinity label that produces selective and long-lasting κ antagonism in mice Regulatory Peptides. 54: 49-50. DOI: 10.1016/0167-0115(94)90383-2 |
0.584 |
|
| 1993 |
Takemori AE, Portoghese PS. The mixed antinociceptive agonist-antagonist activity of beta-endorphin(1-27) in mice. Life Sciences. 53: 1049-52. PMID 8396188 DOI: 10.1016/0024-3205(93)90257-4 |
0.532 |
|
| 1993 |
Portoghese PS, Moe ST, Takemori AE. A selective delta 1 opioid receptor agonist derived from oxymorphone. Evidence for separate recognition sites for delta 1 opioid receptor agonists and antagonists. Journal of Medicinal Chemistry. 36: 2572-4. PMID 8394935 DOI: 10.1021/Jm00069A017 |
0.607 |
|
| 1993 |
Miyamoto Y, Portoghese PS, Takemori AE. Involvement of delta 2 opioid receptors in acute dependence on morphine in mice. The Journal of Pharmacology and Experimental Therapeutics. 265: 1325-7. PMID 8389861 |
0.329 |
|
| 1993 |
Negus SS, Henriksen SJ, Mattox A, Pasternak GW, Portoghese PS, Takemori AE, Weinger MB, Koob GF. Effect of antagonists selective for mu, delta and kappa opioid receptors on the reinforcing effects of heroin in rats. The Journal of Pharmacology and Experimental Therapeutics. 265: 1245-52. PMID 8389859 |
0.407 |
|
| 1993 |
Portoghese PS. The design of δ-selective opioid receptor antagonists Farmaco. 48: 243-251. PMID 8388215 |
0.482 |
|
| 1993 |
Tseng LF, Collins KA, Portoghese PS. Spinal δ2 but not δ1 opioid receptors are involved in intracereboventricular β-endorphin-induced antinociception in the mouse Life Sciences. 52: PL211-PL215. PMID 8387138 DOI: 10.1016/0024-3205(93)90062-8 |
0.499 |
|
| 1993 |
Miyamoto Y, Portoghese PS, Takemori AE. Involvement of delta 2 opioid receptors in the development of morphine dependence in mice. The Journal of Pharmacology and Experimental Therapeutics. 264: 1141-5. PMID 8383738 |
0.482 |
|
| 1993 |
Sofuoglu M, Portoghese PS, Takemori AE. 7-Benzylidenenaltrexone (BNTX): a selective delta 1 opioid receptor antagonist in the mouse spinal cord. Life Sciences. 52: 769-75. PMID 8383271 DOI: 10.1016/0024-3205(93)90240-4 |
0.562 |
|
| 1993 |
Reid LD, Hubbell CL, Glaccum MB, Bilsky EJ, Portoghese PS, Porreca F. Naltrindole, an opioid delta receptor antagonist, blocks cocaine-induced facilitation of responding for rewarding brain stimulation Life Sciences. 52: PL67-PL71. PMID 8382329 DOI: 10.1016/0024-3205(93)90084-G |
0.365 |
|
| 1993 |
Wild KD, Carlisi VJ, Mosberg HI, Bowen WD, Portoghese PS, Sultana M, Takemori AE, Hruby VJ, Porreca F. Evidence for a single functional opioid delta receptor subtype in the mouse isolated vas deferens. The Journal of Pharmacology and Experimental Therapeutics. 264: 831-8. PMID 8382281 |
0.392 |
|
| 1993 |
Olmsted SL, Takemori AE, Portoghese PS. A remarkable change of opioid receptor selectivity on the attachment of a peptidomimetic kappa address element to the delta antagonist, natrindole: 5'-[N2-alkylamidino)methyl]naltrindole derivatives as a novel class of kappa opioid receptor antagonists. Journal of Medicinal Chemistry. 36: 179-80. PMID 8380614 DOI: 10.1021/Jm00053A025 |
0.595 |
|
| 1993 |
Lin CE, Takemori AE, Portoghese PS. Synthesis and kappa-opioid antagonist selectivity of a norbinaltorphimine congener. Identification of the address moiety required for kappa-antagonist activity. Journal of Medicinal Chemistry. 36: 2412-5. PMID 8360887 DOI: 10.1021/Jm00068A020 |
0.544 |
|
| 1993 |
Jones DN, Bowen WD, Portoghese PS, Holtzman SG. Delta-opioid receptor antagonists attenuate motor activity induced by amphetamine but not cocaine. European Journal of Pharmacology. 249: 167-77. PMID 8287898 DOI: 10.1016/0014-2999(93)90429-L |
0.512 |
|
| 1993 |
Takemori AE, Portoghese PS. Enkephalin antinociception in mice is mediated by delta 1- and delta 2-opioid receptors in the brain and spinal cord, respectively. European Journal of Pharmacology. 242: 145-50. PMID 8253111 DOI: 10.1016/0014-2999(93)90074-R |
0.576 |
|
| 1993 |
Chakrabarti S, Sultana M, Portoghese PS, Takemori AE. Differential antagonism by naltrindole-5'-isothiocyanate on [3H]DSLET and [3H]DPDPE binding to striatal slices of mice. Life Sciences. 53: 1761-5. PMID 8246672 DOI: 10.1016/0024-3205(93)90163-W |
0.38 |
|
| 1993 |
Larson DL, Hua M, Takemori AE, Portoghese PS. Possible contribution of a glutathione conjugate to the long-duration action of beta-funaltrexamine. Journal of Medicinal Chemistry. 36: 3669-73. PMID 8246236 DOI: 10.1021/Jm00075A023 |
0.434 |
|
| 1993 |
Vanderah TW, Wild KD, Takemori AE, Sultana M, Portoghese PS, Bowen WD, Hruby VJ, Mosberg HI, Porreca F. Modulation of morphine antinociception by swim-stress in the mouse: involvement of supraspinal opioid delta-2 receptors. The Journal of Pharmacology and Experimental Therapeutics. 267: 449-55. PMID 8229774 |
0.419 |
|
| 1993 |
Kong H, Raynor K, Yasuda K, Moe ST, Portoghese PS, Bell GI, Reisine T. A single residue, aspartic acid 95, in the δ opioid receptor specifies selective high affinity agonist binding Journal of Biological Chemistry. 268: 23055-23058. PMID 8226821 |
0.519 |
|
| 1993 |
Sultana M, Takemori AE, Portoghese PS. 7-Benzylidenenaltrexone (BNTX), a highly selective δ1 antagonist, the first clear evidence for δ receptor subtypes based on binding Nida Research Monograph Series. 130. |
0.346 |
|
| 1992 |
Menkens K, Bilsky EJ, Wild KD, Portoghese PS, Reid LD, Porreca F. Cocaine place preference is blocked by the δ-opioid receptor antagonist, naltrindole European Journal of Pharmacology. 219: 345-346. PMID 1425962 DOI: 10.1016/0014-2999(92)90319-Y |
0.405 |
|
| 1992 |
Portoghese PS, Larson DL, Sultana M, Takemori AE. Opioid agonist and antagonist activities of morphindoles related to naltrindole. Journal of Medicinal Chemistry. 35: 4325-9. PMID 1333013 DOI: 10.1021/Jm00101A009 |
0.609 |
|
| 1992 |
Portoghese PS. Chemical tools in opioid research Nida Research Monograph. 119: 27-33. PMID 1331796 |
0.343 |
|
| 1992 |
Portoghese PS, Sultana M, Nelson WL, Klein P, Takemori AE. Delta opioid antagonist activity and binding studies of regioisomeric isothiocyanate derivatives of naltrindole: evidence for delta receptor subtypes. Journal of Medicinal Chemistry. 35: 4086-91. PMID 1331455 DOI: 10.1021/Jm00100A014 |
0.707 |
|
| 1992 |
Freye E, Latasch L, Portoghese PS. The delta receptor is involved in sufentanil-induced respiratory depression-opioid subreceptors mediate different effects European Journal of Anaesthesiology. 9: 457-462. PMID 1330549 |
0.46 |
|
| 1992 |
Schoffelmeer ANM, De Vries TJ, Hogenboom F, Hruby VJ, Portoghese PS, Mulder AH. Opioid receptor antagonists discriminate between presynaptic mu and delta receptors and the adenylate cyclase-coupled opioid receptor complex in the brain Journal of Pharmacology and Experimental Therapeutics. 263: 20-24. PMID 1328606 |
0.474 |
|
| 1992 |
Porreca F, Takemori AE, Sultana M, Portoghese PS, Bowen WD, Mosberg HI. Modulation of mu-mediated antinociception in the mouse involves opioid delta-2 receptors. The Journal of Pharmacology and Experimental Therapeutics. 263: 147-52. PMID 1328602 |
0.499 |
|
| 1992 |
Portoghese PS, Sultana M, Nagase H, Takemori AE. A highly selective delta 1-opioid receptor antagonist: 7-benzylidenenaltrexone. European Journal of Pharmacology. 218: 195-6. PMID 1327826 DOI: 10.1016/0014-2999(92)90167-3 |
0.492 |
|
| 1992 |
Sofuoglu M, Portoghese PS, Takemori AE. delta-Opioid receptor binding in mouse brain: evidence for heterogeneous binding sites. European Journal of Pharmacology. 216: 273-7. PMID 1327813 DOI: 10.1016/0014-2999(92)90370-J |
0.383 |
|
| 1992 |
Vanderah TW, Wild KD, Takemori AE, Sultana M, Portoghese PS, Bowen WD, Mosberg HI, Porreca F. Mediation of swim-stress antinociception by the opioid delta 2 receptor in the mouse. The Journal of Pharmacology and Experimental Therapeutics. 262: 190-7. PMID 1320682 |
0.43 |
|
| 1992 |
Takemori AE, Portoghese PS. Selective naltrexone-derived opioid receptor antagonists. Annual Review of Pharmacology and Toxicology. 32: 239-69. PMID 1318671 DOI: 10.1146/Annurev.Pa.32.040192.001323 |
0.612 |
|
| 1992 |
Sofuoglu M, Portoghese PS, Takemori AE. Maintenance of acute morphine tolerance in mice by selective blockage of kappa opioid receptors with norbinaltorphimine. European Journal of Pharmacology. 210: 159-62. PMID 1318206 DOI: 10.1016/0014-2999(92)90666-R |
0.518 |
|
| 1992 |
Portoghese PS. Edward E. Smissman-Bristol-Myers Squibb Award Address. The role of concepts in structure-activity relationship studies of opioid ligands Journal of Medicinal Chemistry. 35: 1927-1937. PMID 1317919 DOI: 10.1021/Jm00089A001 |
0.6 |
|
| 1992 |
Takemori AE, Sultana M, Nagase H, Portoghese PS. Agonist and antagonist activities of ligands derived from naltrexone and oxymorphone. Life Sciences. 50: 1491-5. PMID 1315896 DOI: 10.1016/0024-3205(92)90138-F |
0.605 |
|
| 1992 |
Mattia A, Farmer SC, Takemori AE, Sultana M, Portoghese PS, Mosberg HI, Bowen WD, Porreca F. Spinal opioid delta antinociception in the mouse: mediation by a 5'-NTII-sensitive delta receptor subtype. The Journal of Pharmacology and Experimental Therapeutics. 260: 518-25. PMID 1310737 |
0.468 |
|
| 1992 |
Portoghese PS. An approach to the design of receptor-type-selective non-peptide antagonists of peptidergic receptors: Δ opioid antagonists Journal De Pharmacie De Belgique. 47: 337-344. DOI: 10.1021/Jm00110A001 |
0.552 |
|
| 1992 |
Nagase H, Portoghese PS. Abnormal reaction of 4,5-epoxydihydromorohinones and its application to the syntheses of opioid receptor antagonists Journal of Pharmacobio-Dynamics. 15: s-41. |
0.472 |
|
| 1991 |
Portoghese PS, Nagase H, MaloneyHuss KE, Lin CE, Takemori AE. Role of spacer and address components in peptidomimetic delta opioid receptor antagonists related to naltrindole. Journal of Medicinal Chemistry. 34: 1715-20. PMID 1851846 DOI: 10.1021/Jm00109A027 |
0.611 |
|
| 1991 |
Portoghese PS, Garzon-Aburbeh A, Nagase H, Lin CE, Takemori AE. Role of the spacer in conferring kappa opioid receptor selectivity to bivalent ligands related to norbinaltorphimine. Journal of Medicinal Chemistry. 34: 1292-6. PMID 1849995 DOI: 10.1021/Jm00108A008 |
0.565 |
|
| 1991 |
Vink R, Portoghese PS, Faden AI. κ-Opioid antagonist improves cellular bioenergetics and recovery after traumatic brain injury American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 261: R1527-R1532. PMID 1661103 DOI: 10.1152/Ajpregu.1991.261.6.R1527 |
0.386 |
|
| 1991 |
Sofuoglu M, Portoghese PS, Takemori AE. Cross-tolerance studies in the spinal cord of beta-FNA-treated mice provides further evidence for delta opioid receptor subtypes. Life Sciences. 49: PL153-6. PMID 1658509 DOI: 10.1016/0024-3205(91)90397-T |
0.465 |
|
| 1991 |
Portoghese PS, Garzon-Aburbeh A, Larson DL. Persistent binding of fatty acyl derivatives of naltrexamine to opioid receptors. Journal of Medicinal Chemistry. 34: 1966-9. PMID 1648619 DOI: 10.1021/Jm00111A007 |
0.478 |
|
| 1990 |
Peterson PK, Sharp BM, Gekker G, Portoghese PS, Sannerud K, Balfour HH. Morphine promotes the growth of HIV-1 in human peripheral blood mononuclear cell cocultures Aids. 4: 869-873. PMID 2174676 DOI: 10.1097/00002030-199009000-00006 |
0.351 |
|
| 1990 |
Heijna MH, Padt M, Hogenboom F, Portoghese PS, Mulder AH, Schoffelmeer AN. Opioid receptor-mediated inhibition of dopamine and acetylcholine release from slices of rat nucleus accumbens, olfactory tubercle and frontal cortex. European Journal of Pharmacology. 181: 267-78. PMID 2166675 DOI: 10.1016/0014-2999(90)90088-N |
0.45 |
|
| 1990 |
Portoghese PS, Sultana M, Takemori AE. Design of peptidomimetic delta opioid receptor antagonists using the message-address concept. Journal of Medicinal Chemistry. 33: 1714-20. PMID 2160538 DOI: 10.1021/Jm00168A028 |
0.611 |
|
| 1990 |
Portoghese PS, Sultana M, Takemori AE. Naltrindole 5'-isothiocyanate: a nonequilibrium, highly selective delta opioid receptor antagonist. Journal of Medicinal Chemistry. 33: 1547-8. PMID 2160532 DOI: 10.1021/jm00168a004 |
0.527 |
|
| 1990 |
Quock RM, Best JA, Chen DC, Vaughn LK, Portoghese PS, Takemori AE. Mediation of nitrous oxide analgesia in mice by spinal and supraspinal kappa-opioid receptors. European Journal of Pharmacology. 175: 97-100. PMID 2157601 DOI: 10.1016/0014-2999(90)90158-3 |
0.475 |
|
| 1990 |
Levine AS, Grace M, Billington CJ, Portoghese PS. Nor-binaltorphimine decreases deprivation and opioid-induced feeding. Brain Research. 534: 60-4. PMID 1963567 DOI: 10.1016/0006-8993(90)90112-O |
0.433 |
|
| 1990 |
Takemori AE, Yim CB, Larson DL, Portoghese PS. Long-acting agonist and antagonist activities of naltrexamine bivalent ligands in mice. European Journal of Pharmacology. 186: 285-8. PMID 1963149 DOI: 10.1016/0014-2999(90)90445-C |
0.454 |
|
| 1990 |
Portoghese PS, Sultana M, Takemori AE. Design of peptidomimetic .delta. opioid receptor antagonists using the message-address concept [Erratum to document cited in CA112(25):235659s] Journal of Medicinal Chemistry. 33: 3229-3229. DOI: 10.1021/Jm00174A021 |
0.503 |
|
| 1990 |
Sofuoglu M, Portoghese PS, Takemori AE. Differential antagonism of DSLET and DPDPE by novel delta opioid receptor antagonists European Journal of Pharmacology. 183: 2322. DOI: 10.1016/0014-2999(90)93879-U |
0.598 |
|
| 1989 |
Garzon-Aburbeh A, Lipkowski AW, Larson DL, Portoghese PS. Transfer of fatty acyl groups from membrane phosphatides to opiate ligands. Neurochemistry International. 15: 207-14. PMID 20504485 DOI: 10.1016/0197-0186(89)90102-2 |
0.361 |
|
| 1989 |
Sander HW, Portoghese PS, Gintzler AR. Spinal kappa-opiate receptor involvement in the analgesia of pregnancy: effects of intrathecal nor-binaltorphimine, a kappa-selective antagonist. Brain Research. 474: 343-7. PMID 2850091 DOI: 10.1016/0006-8993(88)90448-9 |
0.51 |
|
| 1989 |
Takemori AE, Portoghese PS. The use of mu opioid receptors in the mouse vas deferens for the study of opiate tolerance. European Journal of Pharmacology. 174: 267-71. PMID 2560981 DOI: 10.1016/0014-2999(89)90319-1 |
0.585 |
|
| 1989 |
Carr KD, Bak TH, Simon EJ, Portoghese PS. Effects of the selective kappa opioid antagonist, nor-binaltorphimine, on electrically-elicited feeding in the rat Life Sciences. 45: 1787-1792. PMID 2556617 DOI: 10.1016/0024-3205(89)90518-3 |
0.473 |
|
| 1989 |
Portoghese PS. Bivalent ligands and the message-address concept in the design of selective opioid receptor antagonists. Trends in Pharmacological Sciences. 10: 230-5. PMID 2549665 DOI: 10.1016/0165-6147(89)90267-8 |
0.503 |
|
| 1989 |
Werling LL, McMahon PN, Portoghese PS, Takemori AE, Cox BM. Selective opioid antagonist effects on opioid-induced inhibition of release of norepinephrine in guinea pig cortex. Neuropharmacology. 28: 103-7. PMID 2541364 DOI: 10.1016/0028-3908(89)90044-0 |
0.564 |
|
| 1989 |
Tortella FC, Echevarria E, Lipkowski AW, Takemori AE, Portoghese PS, Holaday JW. Selective kappa antagonist properties of nor-binaltorphimine in the rat MES seizure model. Life Sciences. 44: 661-5. PMID 2538689 DOI: 10.1016/0024-3205(89)90470-0 |
0.541 |
|
| 1989 |
Botros S, Lipkowski AW, Larson DL, Stark PA, Takemori AE, Portoghese PS. Opioid agonist and antagonist activities of peripherally selective derivatives of naltrexamine and oxymorphamine. Journal of Medicinal Chemistry. 32: 2068-71. PMID 2475628 DOI: 10.1021/jm00129a009 |
0.437 |
|
| 1988 |
Takahashi M, Portoghese PS, Takemori AE. Irreversible binding of [3H]beta-funaltrexamine to brain slices of morphine-tolerant and -dependent mice. European Journal of Pharmacology. 149: 205-12. PMID 3409950 DOI: 10.1016/0014-2999(88)90650-4 |
0.519 |
|
| 1988 |
Portoghese PS, Nagase H, Takemori AE. Only one pharmacophore is required for the kappa opioid antagonist selectivity of norbinaltorphimine. Journal of Medicinal Chemistry. 31: 1344-7. PMID 2838632 DOI: 10.1021/Jm00402A015 |
0.578 |
|
| 1988 |
Portoghese PS, Nagase H, Lipkowski AW, Larson DL, Takemori AE. Binaltorphimine-related bivalent ligands and their kappa opioid receptor antagonist selectivity. Journal of Medicinal Chemistry. 31: 836-41. PMID 2832604 DOI: 10.1021/Jm00399A026 |
0.58 |
|
| 1988 |
Portoghese PS, Sultana M, Takemori AE. Naltrindole, a highly selective and potent non-peptide delta opioid receptor antagonist. European Journal of Pharmacology. 146: 185-6. PMID 2832195 DOI: 10.1016/0014-2999(88)90502-X |
0.547 |
|
| 1988 |
Portoghese PS, Sultana M, Nagase H, Takemori AE. Application of the message-address concept in the design of highly potent and selective non-peptide delta opioid receptor antagonists. Journal of Medicinal Chemistry. 31: 281-2. PMID 2828619 DOI: 10.1021/Jm00397A001 |
0.519 |
|
| 1988 |
Portoghese PS, Nagase H, Lipkowski AW, Larson DL, Takemori AE. Binaltorphimine-related bivalent ligands and their .kappa. opioid receptor antagonist selectivity [Erratum to document cited in CA108(17):150771q] Journal of Medicinal Chemistry. 31: 2056-2056. DOI: 10.1021/Jm00118A035 |
0.515 |
|
| 1987 |
Lovett JA, Portoghese PS. Synthesis and evaluation of melphalan-containing N,N-dialkylenkephalin analogues as irreversible antagonists of the delta opioid receptor. Journal of Medicinal Chemistry. 30: 1668-74. PMID 3041000 DOI: 10.1021/Jm00392A025 |
0.543 |
|
| 1987 |
Urbanczyk-Lipkowska Z, Lipkowski AW, Etter MC, Hahn EF, Pasternak GW, Portoghese PS. X-ray crystal structure of the opioid ligand naltrexonazine. Journal of Medicinal Chemistry. 30: 1489-94. PMID 3039139 DOI: 10.1021/Jm00391A035 |
0.519 |
|
| 1987 |
Lovett JA, Portoghese PS. N,N-dialkylated leucine enkephalins as potential delta opioid receptor antagonists. Journal of Medicinal Chemistry. 30: 1144-9. PMID 3037078 DOI: 10.1021/Jm00390A005 |
0.453 |
|
| 1987 |
Schoenecker JW, Takemori AE, Portoghese PS. Nonequilibrium opioid antagonist activity of 6,14-dideoxynaltrexone derivatives. Journal of Medicinal Chemistry. 30: 1040-4. PMID 3035177 DOI: 10.1021/Jm00389A014 |
0.493 |
|
| 1987 |
Schoenecker JW, Takemori AE, Portoghese PS. Opioid agonist and antagonist activities of monofunctional nitrogen mustard analogues of beta-chlornaltrexamine. Journal of Medicinal Chemistry. 30: 933-5. PMID 3033246 DOI: 10.1021/Jm00388A033 |
0.5 |
|
| 1987 |
Portoghese PS, Lipkowski AW, Takemori AE. Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists. Life Sciences. 40: 1287-92. PMID 2882399 DOI: 10.1016/0024-3205(87)90585-6 |
0.624 |
|
| 1987 |
Lipkowski AW, Tam SW, Portoghese PS. Peptides as receptor selectivity modulators of opiate pharmacophores. Journal of Medicinal Chemistry. 29: 1222-5. PMID 2879914 DOI: 10.1002/Chin.198648315 |
0.554 |
|
| 1987 |
Portoghese PS, Larson DL, Ronsisvalle G, Schiller PW, Nguyen TM, Lemieux C, Takemori AE. Hybrid bivalent ligands with opiate and enkephalin pharmacophores. Journal of Medicinal Chemistry. 30: 1991-4. PMID 2444704 DOI: 10.1021/Jm00394A010 |
0.548 |
|
| 1987 |
Urba?czyk-Lipkowska Z, Etter MC, Lipkowski AW, Portoghese PS. The crystal structure of a bimorphinan with highly selective kappa opioid receptor antagonist activity Journal of Molecular Structure. 159: 287-295. DOI: 10.1016/0022-2860(87)80047-9 |
0.456 |
|
| 1987 |
SCHOENECKER JW, TAKEMORI AE, PORTOGHESE PS. ChemInform Abstract: Opioid Agonist and Antagonist Activities of Monofunctional Nitrogen Mustard Analogues (I) of β-Chlornaltrexamine. Cheminform. 18. DOI: 10.1002/chin.198746353 |
0.41 |
|
| 1987 |
PORTOGHESE PS, LARSON DL, SAYRE LM, YIM CB, RONSISVALLE G, TAM SW, TAKEMORI AE. ChemInform Abstract: Opioid Agonist and Antagonist Bivalent Ligands. The Relationship between Spacer Length and Selectivity at Multiple Opioid Receptors. Cheminform. 18. DOI: 10.1002/chin.198711343 |
0.527 |
|
| 1987 |
PORTOGHESE PS, REIN MD, TAKEMORI AE. ChemInform Abstract: Synthesis and Biological Activity of Analogues of β-Chlornaltrexamine and β-Funaltrexamine at Opioid Receptors. Cheminform. 18. DOI: 10.1002/chin.198711314 |
0.317 |
|
| 1987 |
SCHOENECKER JW, TAKEMORI AE, PORTOGHESE PS. ChemInform Abstract: Irreversible Blockage of Opioid Receptor Types by Ester Homologues of β-Funaltrexamine. Cheminform. 18. DOI: 10.1002/chin.198711313 |
0.417 |
|
| 1987 |
PORTOGHESE PS, RONSISVALLE G, LARSON DL, TAKEMORI AE. ChemInform Abstract: Synthesis and Opioid Antagonist Potencies of Naltrexamine Bivalent Ligands with Conformationally Restricted Spacers. Cheminform. 18. DOI: 10.1002/chin.198706307 |
0.465 |
|
| 1987 |
MOHAMED MS, LARSON DL, TAKEMORI AE, PORTOGHESE PS. ChemInform Abstract: Activity of N-Methyl-α- and -β-funaltrexamine at Opioid Receptors. Cheminform. 18. DOI: 10.1002/chin.198704313 |
0.353 |
|
| 1986 |
Aceto MD, Dewey WL, Portoghese PS, Takemori AE. Effects of beta-funaltrexamine (beta-FNA) on morphine dependence in rats and monkeys. European Journal of Pharmacology. 123: 387-93. PMID 3720824 DOI: 10.1016/0014-2999(86)90713-2 |
0.475 |
|
| 1986 |
Griffin JF, Larson DL, Portoghese PS. Crystal structures of α- and β-funaltrexamine: Conformational requirement of the fumaramate moiety in the irreversible blockage of μ opioid receptors Journal of Medicinal Chemistry. 29: 778-783. PMID 3701789 DOI: 10.1002/Chin.198638064 |
0.392 |
|
| 1986 |
Sugg EE, Portoghese PS. Investigation of 4-(3-hydroxyphenyl)-4-methylpipecolic acid as a conformationally restricted mimic of the tyrosyl residue of leucine-enkephalinamide. Journal of Medicinal Chemistry. 29: 2028-33. PMID 3020252 DOI: 10.1021/Jm00160A039 |
0.414 |
|
| 1986 |
Schoenecker JW, Takemori AE, Portoghese PS. Irreversible blockage of opioid receptor types by ester homologues of beta-funaltrexamine. Journal of Medicinal Chemistry. 29: 1868-71. PMID 3020246 DOI: 10.1021/Jm00160A013 |
0.571 |
|
| 1986 |
Portoghese PS, Rein MD, Takemori AE. Synthesis and biological activity of analogues of beta-chlornaltrexamine and beta-funaltrexamine at opioid receptors. Journal of Medicinal Chemistry. 29: 1861-4. PMID 3020245 DOI: 10.1021/Jm00160A011 |
0.524 |
|
| 1986 |
Portoghese PS, Larson DL, Sayre LM, Yim CB, Ronsisvalle G, Tam SW, Takemori AE. Opioid agonist and antagonist bivalent ligands. The relationship between spacer length and selectivity at multiple opioid receptors. Journal of Medicinal Chemistry. 29: 1855-61. PMID 3020244 DOI: 10.1021/Jm00160A010 |
0.61 |
|
| 1986 |
Portoghese PS, Ronsisvalle G, Larson DL, Takemori AE. Synthesis and opioid antagonist potencies of naltrexamine bivalent ligands with conformationally restricted spacers. Journal of Medicinal Chemistry. 29: 1650-3. PMID 3018242 DOI: 10.1021/Jm00159A014 |
0.601 |
|
| 1986 |
Mohamed MS, Larson DL, Takemori AE, Portoghese PS. Activity of N-methyl-alpha- and -beta-funaltrexamine at opioid receptors. Journal of Medicinal Chemistry. 29: 1551-3. PMID 3016272 DOI: 10.1021/Jm00158A043 |
0.571 |
|
| 1986 |
Takemori AE, Ikeda M, Portoghese PS. The mu, kappa and delta properties of various opioid agonists. European Journal of Pharmacology. 123: 357-61. PMID 3013652 DOI: 10.1016/0014-2999(86)90709-0 |
0.599 |
|
| 1986 |
Botros S, Lipkowski AW, Takemori AE, Portoghese PS. Investigation of the structural requirements for the kappa-selective opioid receptor antagonist, 6 beta,6 beta'-[ethylenebis(oxyethyleneimino)]bis[17-(cyclopropylmethyl)- 4,5 alpha-epoxymorphinan-3,14-diol] (TENA). Journal of Medicinal Chemistry. 29: 874-6. PMID 3009817 DOI: 10.1021/Jm00155A048 |
0.55 |
|
| 1986 |
Lovett JA, Portoghese PS. Melphalan-containing N,N-dialkylenkephalin analogs as potential irreversible antagonists of the delta opioid receptor. Nida Research Monograph. 75: 185-8. PMID 2828969 |
0.407 |
|
| 1986 |
BOTROS S, LIPKOWSKI AW, TAKEMORI AE, PORTOGHESE PS. ChemInform Abstract: Investigation of the Structural Requirements for the K-Selective Opioid Receptor Antagonist, 6β,6β′-[Ethylenebis(oxyethyleneimino)]bis[17-(cyclopropylmethyl)-4,5-epoxymorphinan-3,14-diol] (TENA). Chemischer Informationsdienst. 17. DOI: 10.1002/Chin.198638302 |
0.504 |
|
| 1986 |
Mohamed MS, Portoghese PS. Stereoselectivity of the reduction of naltrexone oxime with borane The Journal of Organic Chemistry. 51: 105-106. DOI: 10.1002/Chin.198625322 |
0.364 |
|
| 1985 |
Zagon IS, McLaughlin PJ, Takemori AE, Portoghese PS. beta-Funaltrexamine (beta-FNA) and neural tumor response in mice. European Journal of Pharmacology. 116: 165-9. PMID 4054212 DOI: 10.1016/0014-2999(85)90198-0 |
0.351 |
|
| 1985 |
Elliott RL, Marks N, Berg MJ, Portoghese PS. Synthesis and biological evaluation of phosphonamidate peptide inhibitors of enkephalinase and angiotensin-converting enzyme Journal of Medicinal Chemistry. 28: 1208-1216. PMID 2993614 DOI: 10.1002/Chin.198551305 |
0.308 |
|
| 1985 |
Portoghese PS, Larson DL, Yim CB, Sayre LM, Ronsisvalle G, Lipkowski AW, Takemori AE, Rice KC, Tam SW. Stereostructure-activity relationship of opioid agonist and antagonist bivalent ligands. Evidence for bridging between vicinal opioid receptors. Journal of Medicinal Chemistry. 28: 1140-1. PMID 2993609 DOI: 10.1002/Chin.198551348 |
0.604 |
|
| 1985 |
Takemori AE, Portoghese PS. Affinity labels for opioid receptors. Annual Review of Pharmacology and Toxicology. 25: 193-223. PMID 2988419 DOI: 10.1146/Annurev.Pa.25.040185.001205 |
0.577 |
|
| 1985 |
Ward SJ, Fries DS, Larson DL, Portoghese PS, Takemori AE. Opioid receptor binding characteristics of the non-equilibrium mu antagonist, beta-funaltrexamine (beta-FNA). European Journal of Pharmacology. 107: 323-30. PMID 2984010 DOI: 10.1016/0014-2999(85)90257-2 |
0.352 |
|
| 1985 |
Portoghese PS, Takemori AE. TENA, a selective kappa opioid receptor antagonist. Life Sciences. 36: 801-5. PMID 2983171 DOI: 10.1016/0024-3205(85)90202-4 |
0.599 |
|
| 1985 |
PORTOGHESE PS, LARSON DL, YIM CB, SAYRE LM, RONSISVALLE G, LIPKOWSKI AW, TAKEMORI AE, RICE KC, TAM SW. ChemInform Abstract: STEREOSTRUCTURE-ACTIVITY RELATIONSHIP OF OPIOID AGONIST AND ANTAGONIST BIVALENT LIGANDS. EVIDENCE FOR BRIDGING BETWEEN VICINAL OPIOID RECEPTORS Chemischer Informationsdienst. 16. DOI: 10.1002/chin.198551348 |
0.528 |
|
| 1985 |
FANG S, TAKEMORI AE, PORTOGHESE PS. ChemInform Abstract: ACTIVITIES OF MORPHINONE AND N-(CYCLOPROPYLMETHYL)NORMORPHINONE AT OPIOID RECEPTORS Chemischer Informationsdienst. 16. DOI: 10.1002/chin.198509358 |
0.481 |
|
| 1985 |
SAYRE LM, LARSON DL, TAKEMORI AE, PORTOGHESE PS. ChemInform Abstract: DESIGN AND SYNTHESIS OF NALTREXONE-DERIVED AFFINITY LABELS WITH NONEQUILIBRIUM OPIOID AGONIST AND ANTAGONIST ACTIVITIES. EVIDENCE FOR THE EXISTENCE OF DIFFERENT μ RECEPTOR SUBTYPES IN DIFFERENT TISSUES Chemischer Informationsdienst. 16. DOI: 10.1002/chin.198509357 |
0.472 |
|
| 1985 |
FANG S, BELL KH, PORTOGHESE PS. ChemInform Abstract: SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF AN 8β-BIS(2-CHLOROETHYL)AMINO OPIATE AS A NONEQUILIBRIUM OPIOID RECEPTOR PROBE Chemischer Informationsdienst. 16. DOI: 10.1002/chin.198504334 |
0.43 |
|
| 1984 |
Fang S, Takemori AE, Portoghese PS. Activities of morphinone and N-(cyclopropylmethyl)normorphinone at opioid receptors. Journal of Medicinal Chemistry. 27: 1361-3. PMID 6207298 DOI: 10.1002/Chin.198509358 |
0.497 |
|
| 1984 |
Takemori AE, Portoghese PS. Comparative antagonism by naltrexone and naloxone of mu, kappa, and delta agonists. European Journal of Pharmacology. 104: 101-4. PMID 6094203 DOI: 10.1016/0014-2999(84)90374-1 |
0.575 |
|
| 1984 |
Sayre LM, Larson DL, Takemori AE, Portoghese PS. Design and synthesis of naltrexone-derived affinity labels with nonequilibrium opioid agonist and antagonist activities. Evidence for the existence of different mu receptor subtypes in different tissues. Journal of Medicinal Chemistry. 27: 1325-35. PMID 6090663 DOI: 10.1002/Chin.198509357 |
0.596 |
|
| 1984 |
Fang SN, Bell KH, Portoghese PS. Synthesis and pharmacological evaluation of an 8 beta-bis(2-chloroethyl)amino opiate as a nonequilibrium opioid receptor probe. Journal of Medicinal Chemistry. 27: 1090-2. PMID 6086925 DOI: 10.1021/Jm00374A026 |
0.524 |
|
| 1984 |
Duax WL, Smith GD, Griffin JF, Strong PD, Portoghese PS. The crystal structure and molecular conformation of threo 5-methylmetadone in relation to opioid receptor binding Tetrahedron. 40: 467-471. DOI: 10.1016/0040-4020(84)85051-6 |
0.426 |
|
| 1984 |
PORTOGHESE PS, TAKEMORI AE. ChemInform Abstract: DIFFERENT RECEPTOR SITES MEDIATE OPIOID AGONISM AND ANTAGONISM Chemischer Informationsdienst. 15. DOI: 10.1002/chin.198413357 |
0.48 |
|
| 1984 |
SAYRE LM, LARSON DL, FRIES DS, TAKEMORI AE, PORTOGHESE PS. ChemInform Abstract: IMPORTANCE OF CARBON 6 CHIRALITY IN CONFERRING IRREVERSIBLE OPIOID ANTAGONISM TO NALTREXONE-DERIVED AFFINITY LABELS Chemischer Informationsdienst. 15. DOI: 10.1002/Chin.198406322 |
0.461 |
|
| 1983 |
Essawi MY, Portoghese PS. Synthesis and evaluation of 1- and 2-substituted fentanyl analogues for opioid activity. Journal of Medicinal Chemistry. 26: 348-52. PMID 6827557 DOI: 10.1021/Jm00357A007 |
0.584 |
|
| 1983 |
Portoghese PS, Takemori AE. Different receptor sites mediate opioid agonism and antagonism. Journal of Medicinal Chemistry. 26: 1341-3. PMID 6312042 DOI: 10.1002/Chin.198413357 |
0.565 |
|
| 1983 |
Sayre LM, Larson DL, Fries DS, Takemori AE, Portoghese PS. Importance of C-6 chirality in conferring irreversible opioid antagonism to naltrexone-derived affinity labels. Journal of Medicinal Chemistry. 26: 1229-35. PMID 6310111 DOI: 10.1021/Jm00363A005 |
0.537 |
|
| 1983 |
Sayre LM, Portoghese PS, Takemori AE. Difference between mu-receptors in the guinea pig ileum and the mouse vas deferens. European Journal of Pharmacology. 90: 159-60. PMID 6307720 DOI: 10.1016/0014-2999(83)90232-7 |
0.521 |
|
| 1983 |
Duax WL, Smith GD, Griffin JF, Portoghese PS. Methadone conformation and opioid activity Science. 220: 417-418. PMID 6301007 DOI: 10.1126/Science.6301007 |
0.492 |
|
| 1983 |
Sayre LM, Takemori AE, Portoghese PS. Alkylation of opioid receptor subtypes by alpha-chlornaltrexamine produces concurrent irreversible agonistic and irreversible antagonistic activities. Journal of Medicinal Chemistry. 26: 503-6. PMID 6300401 DOI: 10.1021/Jm00358A009 |
0.538 |
|
| 1982 |
Ramakrishnan K, Portoghese PS. Synthesis and biological evaluation of a metazocine-containing enkephalinamide. Evidence for nonidentical roles of the tyramine moiety in opiates and opioid peptides Journal of Medicinal Chemistry. 25: 1423-1427. PMID 7154002 DOI: 10.1021/Jm00354A006 |
0.505 |
|
| 1982 |
Erez M, Takemori AE, Portoghese PS. Narcotic antagonistic potency of bivalent ligands which contain beta-naltrexamine. Evidence for bridging between proximal recognition sites. Journal of Medicinal Chemistry. 25: 847-9. PMID 7108900 DOI: 10.1021/Jm00349A016 |
0.552 |
|
| 1982 |
Ward SJ, Portoghese PS, Takemori AE. Improved assays for the assessment of kappa- and delta-properties of opioid ligands. European Journal of Pharmacology. 85: 163-70. PMID 6295778 DOI: 10.1016/0014-2999(82)90461-7 |
0.524 |
|
| 1982 |
Portoghese PS, Ronsisvalle G, Larson DL, Yim CB, Sayre LM, Takemori AE. Opioid agonist and antagonist bivalent ligands as receptor probes. Life Sciences. 31: 1283-6. PMID 6292615 DOI: 10.1016/0024-3205(82)90362-9 |
0.58 |
|
| 1982 |
Ward SJ, Portoghese PS, Takemori AE. Pharmacological profiles of beta-funaltrexamine (beta-FNA) and beta-chlornaltrexamine (beta-CNA) on the mouse vas deferens preparation. European Journal of Pharmacology. 80: 377-84. PMID 6286325 DOI: 10.1016/0014-2999(82)90083-8 |
0.311 |
|
| 1982 |
Portoghese PS, Poupaert JH, Larson DL, Groutas WC, Meitzner GD, Swenson DC, Smith GD, Duax WL. Synthesis, X-ray crystallographic determination, and opioid activity of erythro-5-methylmethadone enantiomers. Evidence which suggests that μ and δ opioid receptors possess different stereochemical requirements Journal of Medicinal Chemistry. 25: 684-688. PMID 6284938 DOI: 10.1002/Chin.198246154 |
0.584 |
|
| 1982 |
Fries DS, Dodge RP, Hope H, Portoghese PS. Stereochemical studies on medicinal agents. 25. Absolute configuration and analgetic potency of beta-1,2-dimethyl-2-phenyl-4-(propionyloxy)piperidine enantiomers. Journal of Medicinal Chemistry. 25: 9-12. PMID 6283082 DOI: 10.1021/Jm00343A002 |
0.499 |
|
| 1982 |
Messing RB, Portoghese PS, Takemori AE, Sparber SB. Antagonism of morphine-induced behavioral suppression by opiate receptor alkylators. Pharmacology, Biochemistry, and Behavior. 16: 621-6. PMID 6280206 DOI: 10.1016/0091-3057(82)90426-9 |
0.4 |
|
| 1981 |
Portoghese PS, Alreja BD, Larson DL. Allylprodine analogues as receptor probes. Evidence that phenolic and nonphenolic ligands interact with different subsites on identical opioid receptors Journal of Medicinal Chemistry. 24: 782-787. PMID 6268787 DOI: 10.1002/Chin.198147219 |
0.576 |
|
| 1981 |
Tulunay FC, Ayhan IH, Portoghese PS, Takemori AE. Antagonism by chlornaltrexamine of some effects of delta 9-tetrahydrocannabinol in rats. European Journal of Pharmacology. 70: 219-24. PMID 6266844 DOI: 10.1016/0014-2999(81)90217-X |
0.461 |
|
| 1981 |
Takemori AE, Larson DL, Portoghese PS. The irreversible narcotic antagonistic and reversible agonistic properties of the fumaramate methyl ester derivative of naltrexone. European Journal of Pharmacology. 70: 445-51. PMID 6263637 DOI: 10.1016/0014-2999(81)90355-1 |
0.417 |
|
| 1980 |
Caruso TP, Larson DL, Portoghese PS, Takemori AE. Isolation of selective 3H-chlornaltrexamine-bound complexes, possible opioid receptor components in brains of mice. Life Sciences. 27: 2063-9. PMID 6259471 DOI: 10.1016/0024-3205(80)90485-3 |
0.331 |
|
| 1980 |
Portoghese PS, Larson DL, Sayre LM, Fries DS, Takemori AE. A novel opioid receptor site directed alkylating agent with irreversible narcotic antagonistic and reversible agonistic activities. Journal of Medicinal Chemistry. 23: 233-4. PMID 6245210 DOI: 10.1021/Jm00177A002 |
0.572 |
|
| 1980 |
Kam ST, Portoghese PS. 9, 11-Azo-12-oxa-15-hydroxyprostanoic acid: a potent thromboxane synthetase inhibitor and a PGH2/TxA2 receptor antagonist. Prostaglandins and Medicine. 3: 279-90. PMID 233035 DOI: 10.1016/0161-4630(79)90069-7 |
0.318 |
|
| 1979 |
Portoghese PS, Larson DL, Jiang JB, Caruso TP, Takemori AE. Synthesis and pharmacologic characterization of an alkylating analogue (chlornaltrexamine) of naltrexone with ultralong-lasting narcotic antagonist properties. Journal of Medicinal Chemistry. 22: 168-73. PMID 218009 DOI: 10.1002/Chin.197925340 |
0.497 |
|
| 1979 |
Caruso TP, Takemori AE, Larson DL, Portoghese PS. Chloroxymorphamine, and opioid receptor site-directed alkylating agent having narcotic agonist activity. Science (New York, N.Y.). 204: 316-8. PMID 86208 DOI: 10.1126/Science.86208 |
0.571 |
|
| 1978 |
Portoghese PS, Larson DL, Jiang JB, Takemori AE, Caruso TP. 6beta-[N,N-Bis(2-chloroethyl)amino]-17-(cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxymorphinan(chlornaltrexamine) a potent opioid receptor alkylating agent with ultralong narcotic antagonist actitivty. Journal of Medicinal Chemistry. 21: 598-9. PMID 209185 DOI: 10.1021/Jm00205A002 |
0.479 |
|
| 1978 |
Portoghese P, Larson D, Jiang J, Takemori A, Caruso T. Additions and Corrections - 6β[N,N-Bis(2-chloroethyl)amino]-17-(cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan(Chlornaltrexamine), a Potent Opioid Receptor Alkylating Agent with Ultralong Narcotic Antagonist Activity Journal of Medicinal Chemistry. 21: 1340-1340. DOI: 10.1021/Jm00210A602 |
0.471 |
|
| 1978 |
Portoghese PS. Stereoisomeric ligands as opioid receptor probes Accounts of Chemical Research. 11: 21-29. DOI: 10.1021/Ar50121A004 |
0.575 |
|
| 1978 |
PORTOGHESE PS, LARSON DL, JIANG JB, TAKEMORI AE, CARUSO TP. ChemInform Abstract: 6β-(N,N-BIS(2-CHLOROETHYL)AMINO)-17-(CYCLOPROPYLMETHYL)-4,5α-EPOXY-3# ,14-DIHYDROXYMORPHINAN (CHLORANALTREXAMINE), A POTENT OPIOID RECEPTOR ALKYLATING AGENT WITH ULTRALONG NARCOTIC ANTAGONIST ACTIVITY Chemischer Informationsdienst. 9. DOI: 10.1002/Chin.197850350 |
0.468 |
|
| 1977 |
Jiang JB, Hanson RN, Portoghese PS, Takemori AE. Stereochemical studies on medicinal agents. 23. Synthesis and biological evaluation of 6-amino derivatives of naloxone and naltrexone. Journal of Medicinal Chemistry. 20: 1100-2. PMID 894682 DOI: 10.1002/Chin.197749253 |
0.43 |
|
| 1977 |
Portoghese PS, Hanson RN, Telang VG, Winger JL, Takemori AE. 3-Hydroxy-17-aralkylmorphinans as potential opiate receptor-site-directed alkylating agents. Journal of Medicinal Chemistry. 20: 1020-4. PMID 197237 DOI: 10.1002/Chin.197749376 |
0.537 |
|
| 1977 |
PERT CB, SNYDER SH, PORTOGHESE PS. ChemInform Abstract: CORRELATION OF OPIATE RECEPTOR AFFINITY WITH ANALGETIC EFFECTS OF MEPERIDINE HOMOLOGS Chemischer Informationsdienst. 8: no-no. DOI: 10.1002/chin.197705241 |
0.374 |
|
| 1976 |
Portoghese PS, Shefter E. Stereochemical studies on medicinal agents. 19. X-ray crystal structures of two (+/-)-allylprodine diastereomers. The role of the allyl group in conferring high stereoselectivity and potency at analgetic receptors. Journal of Medicinal Chemistry. 19: 55-7. PMID 1246054 DOI: 10.1021/Jm00223A012 |
0.369 |
|
| 1976 |
Fries DS, Portoghese PS. Stereochemical studies on medicinal agents. 20. Absolute configuration and analgetic potency of α-promedol2 enantiomers. The role of the C-4 chiral center in conferring stereoselectivity in axial- and equatorial-phenyl prodine congeners Journal of Medicinal Chemistry. 19: 1155-1158. PMID 978670 DOI: 10.1021/Jm00231A014 |
0.32 |
|
| 1974 |
Takemori AE, Ward A, Portoghese PS, Telang VG. Potential nonequilibrium analgetic receptor inactivators. Further pharmacologic studies of N-acylanileridines. Journal of Medicinal Chemistry. 17: 1051-4. PMID 4479531 DOI: 10.1002/Chin.197505281 |
0.413 |
|
| 1974 |
Portoghese PS, Riley TN, Miller JW. Stereochemical studies on medicinal agents. 10. The role of chirality in alpha-adrenergic receptor blockage by (plus)-and(minus)-phenoxybenzamine hydrochloride. Journal of Medicinal Chemistry. 14: 561-4. PMID 4151883 DOI: 10.1021/Jm00289A001 |
0.357 |
|
| 1973 |
Portoghese PS, Gomaa ZSD, Larson DL, Shefter E. Stereochemical studies on medicinal agents. 13. Correlation of the solid-state conformations of 1,3,5-trimethyl- and 1,3-dimethyl-4-phenyl-4-propionoxypiperidine enantiomers with their absolute stereoselectivity at analgetic receptors Journal of Medicinal Chemistry. 16: 199-203. PMID 4733099 DOI: 10.1021/Jm00261A006 |
0.408 |
|
| 1973 |
Larson DL, Portoghese PS. Stereochemical studies on medicinal agents. 12. The distinction of enantiotopic groups in the interaction of 1-methyl-4-phenyl-4-propionoxypiperidine with analgetic receptors Journal of Medicinal Chemistry. 16: 195-198. PMID 4733098 DOI: 10.1021/Jm00261A005 |
0.36 |
|
| 1973 |
Larson D, Portoghese P. Additions and Correction. Stereo-chemical Studies on Medicinal Agents. 12. The Distinction of Enantiotopic Groups in the Interaction of 1-Methyl-4-phenyl-4-propionoxypiperidine with Analgetic Receptors. Journal of Medicinal Chemistry. 16: 1416-1416. DOI: 10.1021/Jm00270A604 |
0.355 |
|
| 1972 |
Portoghese PS. Translocation of ligand conformational free energy in receptor activation: a possible functional role of conformational isomerism in drug action. Journal of Pharmaceutical Sciences. 60: 806-7. PMID 5125793 DOI: 10.1002/Jps.2600600537 |
0.354 |
|
| 1971 |
Portoghese PS, Telang VG, Takemori AE, Hayashi G. Potential nonequilibrium analgetic receptor inactivators. Synthesis and biological activities of N-acylanileridines. Journal of Medicinal Chemistry. 14: 144-8. PMID 5107751 DOI: 10.1021/Jm00284A015 |
0.393 |
|
| 1968 |
Portoghese PS, Larson DL. Absolute stereochemistry and analgesic potency of prodine enantiomers Journal of Pharmaceutical Sciences. 57: 711-713. PMID 5652174 DOI: 10.1002/Jps.2600570444 |
0.434 |
|
| 1966 |
Portoghese PS. A new concept on the mode of interaction of narcotic analgesics with receptors. Journal of Medicinal Chemistry. 8: 609-16. PMID 5867942 DOI: 10.1021/Jm00329A013 |
0.368 |
|
| 1966 |
Portoghese PS. Stereochemical factors and receptor interactions associated with narcotic analgesics. Journal of Pharmaceutical Sciences. 55: 865-87. PMID 5331369 DOI: 10.1002/Jps.2600550902 |
0.394 |
|
| 1965 |
SMISSMAN EE, SCHNETTLER RA, PORTOGHESE PS. MECHANISM OF THE PRINS REACTION. STEREOASPECTS OF THE FORMATION OF 1,3-DIOXANES. The Journal of Organic Chemistry. 30: 797-801. PMID 14285672 DOI: 10.1021/Jo01014A034 |
0.504 |
|
| 1965 |
Portoghese PS, Riley TN. Stereochemical Studies on Medicinal Agents III. Influence of Length of N-aralkyl Group on Configurational Selectivity of Receptors Toward Enantiomeric Basic Anilide Analgesics Journal of Pharmaceutical Sciences. 54: 1831-1833. DOI: 10.1002/Jps.2600541237 |
0.45 |
|
| 1965 |
Portoghese PS. Linear Free Energy Relationship Among Analgesic N-Substituted Phenylpiperidine Derivatives. Method of Detecting Similar Modes of Molecular Binding to Common Receptors Journal of Pharmaceutical Sciences. 54: 1077-1079. DOI: 10.1002/Jps.2600540736 |
0.352 |
|
| 1962 |
PORTOGHESE PS, SMISSMAN EE. Stereoaspects of the Prins Reaction of Anethole1 The Journal of Organic Chemistry. 27: 719-722. DOI: 10.1021/Jo01050A003 |
0.498 |
|
| 1961 |
SMISSMAN EE, PORTOGHESE PS, MODE RA. Stereochemistry of the Cyclization of the Half-Esters of Diarylitaconic Acid The Journal of Organic Chemistry. 26: 3628-3631. DOI: 10.1021/Jo01068A003 |
0.514 |
|
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