| Year |
Citation |
Score |
| 2024 |
Lee HM, Park JH, Kim TH, Kim HS, Kim DE, Lee MK, You J, Lee GM, Kim YG. Effects of autophagy-inhibiting chemicals on sialylation of Fc-fusion glycoprotein in recombinant CHO cells. Applied Microbiology and Biotechnology. 108: 224. PMID 38376550 DOI: 10.1007/s00253-024-13059-9 |
0.381 |
|
| 2024 |
Kim SH, Park JH, Shin S, Shin S, Chun D, Kim YG, Yoo J, You WK, Lee JS, Lee GM. Genome-Wide CRISPR/Cas9 Screening Unveils a Novel Target ATF7IP-SETDB1 Complex for Enhancing Difficult-to-Express Protein Production. Acs Synthetic Biology. PMID 38240694 DOI: 10.1021/acssynbio.3c00646 |
0.327 |
|
| 2023 |
Kim D, Kim SH, Yoon C, Lee GM. Genome-wide CRISPR/Cas9 knockout screening to mitigate cell growth inhibition induced by histone deacetylase inhibitors in recombinant CHO cells. Biotechnology and Bioengineering. PMID 38013500 DOI: 10.1002/bit.28611 |
0.382 |
|
| 2023 |
Yoon C, Baek KE, Kim D, Lee GM. Mitigating transcriptional bottleneck using a constitutively active transcription factor, VP16-CREB, in mammalian cells. Metabolic Engineering. PMID 37709006 DOI: 10.1016/j.ymben.2023.09.005 |
0.315 |
|
| 2023 |
Kim SH, Shin S, Baek M, Xiong K, Karottki KJC, Hefzi H, Grav LM, Pedersen LE, Kildegaard HF, Lewis NE, Lee JS, Lee GM. Identification of hyperosmotic stress-responsive genes in Chinese hamster ovary cells via genome-wide virus-free CRISPR/Cas9 screening. Metabolic Engineering. PMID 37709005 DOI: 10.1016/j.ymben.2023.09.006 |
0.589 |
|
| 2023 |
Kang DE, An YB, Kim Y, Ahn S, Kim YJ, Lim JS, Ryu SH, Choi H, Yoo J, You WK, Lee DY, Park J, Hong M, Lee GM, Baik JY, et al. Enhanced cell growth, production, and mAb quality produced in Chinese hamster ovary-K1 cells by supplementing polyamine in the media. Applied Microbiology and Biotechnology. PMID 36947192 DOI: 10.1007/s00253-023-12459-7 |
0.417 |
|
| 2022 |
Ha TK, Òdena A, Karottki KJC, Kim CL, Hefzi H, Lee GM, Faustrup Kildegaard H, Nielsen LK, Grav LM, Lewis NE. Enhancing CHO cell productivity through a dual selection system using Aspg and Gs in glutamine free medium. Biotechnology and Bioengineering. PMID 36562657 DOI: 10.1002/bit.28318 |
0.584 |
|
| 2022 |
Shin S, Kim SH, Park JH, Lee JS, Lee GM. Recombinase-mediated cassette exchange-based screening of a CRISPR/Cas9 library for enhanced recombinant protein production in human embryonic kidney cells: Improving resistance to hyperosmotic stress. Metabolic Engineering. 72: 247-258. PMID 35398513 DOI: 10.1016/j.ymben.2022.03.017 |
0.336 |
|
| 2021 |
Xiong K, Karottki KJC, Hefzi H, Li S, Grav LM, Li S, Spahn P, Lee JS, Ventina I, Lee GM, Lewis NE, Kildegaard HF, Pedersen LE. Erratum: An optimized genome-wide, virus-free CRISPR screen for mammalian cells. Cell Reports Methods. 1: 100115. PMID 35475003 DOI: 10.1016/j.crmeth.2021.100115 |
0.492 |
|
| 2021 |
Kim D, Yoon C, Lee GM. Small molecule epigenetic modulators for enhancing recombinant antibody production in CHO cell cultures. Biotechnology and Bioengineering. PMID 34961935 DOI: 10.1002/bit.28013 |
0.336 |
|
| 2021 |
Xiong K, Karottki KJC, Hefzi H, Li S, Grav LM, Li S, Spahn P, Lee JS, Ventina I, Lee GM, Lewis NE, Kildegaard HF, Pedersen LE. An optimized genome-wide, virus-free CRISPR screen for mammalian cells. Cell Reports Methods. 1. PMID 34935002 DOI: 10.1016/j.crmeth.2021.100062 |
0.533 |
|
| 2021 |
Kim SH, Baek M, Park S, Shin S, Lee JS, Lee GM. Improving the secretory capacity of CHO producer cells: The effect of controlled Blimp1 expression, a master transcription factor for plasma cells. Metabolic Engineering. 69: 73-86. PMID 34775077 DOI: 10.1016/j.ymben.2021.11.001 |
0.362 |
|
| 2021 |
Ha TK, Kim D, Kim CL, Grav LM, Lee GM. Factors affecting the quality of therapeutic proteins in recombinant Chinese hamster ovary cell culture. Biotechnology Advances. 107831. PMID 34480988 DOI: 10.1016/j.biotechadv.2021.107831 |
0.359 |
|
| 2021 |
Kim MG, Lee GM. Blockage of undesirable endocytosis of recombinant human growth/differentiation factor-5 in Chinese hamster ovary cell cultures requires heparin analogs with specific chain lengths. Biotechnology Journal. e2100227. PMID 34347378 DOI: 10.1002/biot.202100227 |
0.391 |
|
| 2021 |
Shamie I, Duttke SH, Karottki KJC, Han CZ, Hansen AH, Hefzi H, Xiong K, Li S, Roth SJ, Tao J, Lee GM, Glass CK, Kildegaard HF, Benner C, Lewis NE. A Chinese hamster transcription start site atlas that enables targeted editing of CHO cells. Nar Genomics and Bioinformatics. 3: lqab061. PMID 34268494 DOI: 10.1093/nargab/lqab061 |
0.5 |
|
| 2021 |
Shin S, Kim SH, Lee JS, Lee GM. Streamlined Human Cell-Based Recombinase-Mediated Cassette Exchange Platform Enables Multigene Expression for the Production of Therapeutic Proteins. Acs Synthetic Biology. PMID 34133132 DOI: 10.1021/acssynbio.1c00113 |
0.313 |
|
| 2021 |
Karottki KJC, Hefzi H, Li S, Pedersen LE, Spahn PN, Joshi C, Ruckerbauer D, Bort JAH, Thomas A, Lee JS, Borth N, Lee GM, Kildegaard HF, Lewis NE. A metabolic CRISPR-Cas9 screen in Chinese hamster ovary cells identifies glutamine-sensitive genes. Metabolic Engineering. PMID 33813034 DOI: 10.1016/j.ymben.2021.03.017 |
0.515 |
|
| 2021 |
Kim MG, Kim CL, Kim YS, Jang JW, Lee GM. Selective endocytosis of recombinant human BMPs through cell surface heparan sulfate proteoglycans in CHO cells: BMP-2 and BMP-7. Scientific Reports. 11: 3378. PMID 33564092 DOI: 10.1038/s41598-021-82955-1 |
0.422 |
|
| 2020 |
Lee SY, Baek M, Lee GM. Comprehensive Characterization of Dihydrofolate Reductase-Mediated Gene Amplification for the Establishment of Recombinant Human Embryonic Kidney 293 Cells Producing Monoclonal Antibodies. Biotechnology Journal. e2000351. PMID 33314785 DOI: 10.1002/biot.202000351 |
0.425 |
|
| 2020 |
Park SH, Park JH, Lee JH, Lee HM, Kang YJ, Lee EJ, Shin S, Lee GM, Kim YG. Amplification of EBNA-1 through a single-plasmid vector-based gene amplification system in HEK293 cells as an efficient transient gene expression system. Applied Microbiology and Biotechnology. PMID 33191460 DOI: 10.1007/s00253-020-11001-3 |
0.35 |
|
| 2020 |
Sergeeva D, Lee GM, Nielsen LK, Grav LM. Multi-copy targeted integration for accelerated development of high-producing CHO cells. Acs Synthetic Biology. PMID 32835482 DOI: 10.1021/Acssynbio.0C00322 |
0.449 |
|
| 2020 |
Shin S, Kim SH, Shin SW, Grav LM, Pedersen LE, Lee JS, Lee GM. Comprehensive Analysis of Genomic Safe Harbors as Target Sites for Stable Expression of the Heterologous Gene in HEK293 Cells. Acs Synthetic Biology. PMID 32470292 DOI: 10.1021/Acssynbio.0C00097 |
0.433 |
|
| 2020 |
Kol S, Ley D, Wulff T, Decker M, Arnsdorf J, Schoffelen S, Hansen AH, Jensen TL, Gutierrez JM, Chiang AWT, Masson HO, Palsson BO, Voldborg BG, Pedersen LE, Kildegaard HF, ... Lee GM, et al. Multiplex secretome engineering enhances recombinant protein production and purity. Nature Communications. 11: 1908. PMID 32313013 DOI: 10.1038/S41467-020-15866-W |
0.649 |
|
| 2020 |
Yoon C, Kim D, Lim JH, Lee GM. Forskolin Increases cAMP Levels and Enhances Recombinant Antibody Production in CHO Cell Cultures Biotechnology Journal. 2000264. DOI: 10.1002/Biot.202000264 |
0.489 |
|
| 2019 |
Ha TK, Hansen AH, Kildegaard HF, Lee GM. Knockout of sialidase and pro-apoptotic genes in Chinese hamster ovary cells enables the production of recombinant human erythropoietin in fed-batch cultures. Metabolic Engineering. PMID 31785386 DOI: 10.1016/j.ymben.2019.11.008 |
0.411 |
|
| 2019 |
Julie la Cour Karottki K, Hefzi H, Xiong K, Shamie I, Hansen AH, Li S, Pedersen LE, Li S, Lee JS, Lee GM, Kildegaard HF, Lewis NE. Awakening dormant glycosyltransferases in CHO cells with CRISPRa. Biotechnology and Bioengineering. PMID 31631317 DOI: 10.1002/Bit.27199 |
0.578 |
|
| 2019 |
Lee JS, Kildegaard HF, Lewis NE, Lee GM. Mitigating Clonal Variation in Recombinant Mammalian Cell Lines. Trends in Biotechnology. PMID 30898338 DOI: 10.1016/J.Tibtech.2019.02.007 |
0.594 |
|
| 2019 |
Xiong K, Marquart KF, Karottki KJC, Li S, Shamie I, Lee JS, Gerling S, Yeo NC, Chavez A, Lee GM, Lewis NE, Kildegaard HF. Reduced Apoptosis in Chinese Hamster Ovary Cells via Optimized CRISPR Interference. Biotechnology and Bioengineering. PMID 30883679 DOI: 10.1002/Bit.26969 |
0.608 |
|
| 2019 |
Pristovsek N, Nallapereddy S, Grav LM, Hefzi H, Lewis NE, Rugbjerg P, Hansen HG, Lee GM, Andersen MR, Kildegaard HF. Systematic Evaluation of Site-Specific Recombinant Gene Expression for Programmable Mammalian Cell Engineering. Acs Synthetic Biology. PMID 30807689 DOI: 10.1021/Acssynbio.8B00453 |
0.525 |
|
| 2019 |
Lee JH, Kim J, Park JH, Heo WD, Lee GM. Analysis of Golgi pH in CHO cells using ratiometric pH-sensitive fluorescent proteins. Biotechnology and Bioengineering. PMID 30636290 DOI: 10.1002/Bit.26920 |
0.327 |
|
| 2018 |
Kim CL, Lee GM. Improving recombinant bone morphogenetic protein-4 (BMP-4) production by autoregulatory feedback loop removal using BMP receptor-knockout CHO cell lines. Metabolic Engineering. PMID 30447330 DOI: 10.1016/j.ymben.2018.11.003 |
0.389 |
|
| 2018 |
Lee JS, Park JH, Ha TK, Samoudi M, Lewis N, Palsson BØ, Kildegaard HF, Lee GM. Revealing key determinants of clonal variation in transgene expression in recombinant CHO cells using targeted genome editing. Acs Synthetic Biology. PMID 30388888 DOI: 10.1021/Acssynbio.8B00290 |
0.619 |
|
| 2018 |
Grav LM, Sergeeva D, Lee JS, Marín de Mas I, Lewis NE, Andersen MR, Nielsen LK, Lee GM, Kildegaard HF. Minimizing clonal variation during mammalian cell line engineering for improved systems biology data generation. Acs Synthetic Biology. PMID 30060646 DOI: 10.1021/Acssynbio.8B00140 |
0.591 |
|
| 2018 |
Kim CL, Jung MY, Kim YS, Jang JW, Lee GM. Improving the production of recombinant human bone morphogenetic protein-4 in CHO cell cultures by inhibition of undesirable endocytosis. Biotechnology and Bioengineering. PMID 30011067 DOI: 10.1002/Bit.26798 |
0.509 |
|
| 2018 |
Baek E, Lee JS, Lee GM. Untangling the mechanism of 3-methyladenine (3-MA) in enhancing the specific productivity: Transcriptome analysis of recombinant CHO cells treated with 3-MA. Biotechnology and Bioengineering. PMID 29940077 DOI: 10.1002/bit.26777 |
0.362 |
|
| 2018 |
Lee JH, Park JH, Park SH, Kim SH, Kim JY, Min JK, Lee GM, Kim YG. Co-amplification of EBNA-1 and PyLT through dhfr-mediated gene amplification for improving foreign protein production in transient gene expression in CHO cells. Applied Microbiology and Biotechnology. PMID 29654557 DOI: 10.1007/s00253-018-8977-6 |
0.405 |
|
| 2018 |
Noh SM, Shin S, Lee GM. Comprehensive characterization of glutamine synthetase-mediated selection for the establishment of recombinant CHO cells producing monoclonal antibodies. Scientific Reports. 8: 5361. PMID 29599455 DOI: 10.1038/s41598-018-23720-9 |
0.355 |
|
| 2018 |
Pristovšek N, Hansen HG, Sergeeva D, Borth N, Lee GM, Andersen MR, Kildegaard HF. Using titer and titer normalized to confluence are complementary strategies for obtaining Chinese hamster ovary cell lines with high volumetric productivity of etanercept. Biotechnology Journal. PMID 29359860 DOI: 10.1002/biot.201700216 |
0.353 |
|
| 2018 |
Yu DY, Lee SY, Lee GM. Glutamine synthetase gene knockout-human embryonic kidney 293E cells for stable production of monoclonal antibodies. Biotechnology and Bioengineering. PMID 29359789 DOI: 10.1002/Bit.26552 |
0.518 |
|
| 2017 |
Ha TK, Hansen AH, Kol S, Kildegaard HF, Lee GM. Baicalein reduces oxidative stress in CHO cell cultures and improves recombinant antibody productivity. Biotechnology Journal. PMID 29125225 DOI: 10.1002/biot.201700425 |
0.372 |
|
| 2017 |
Park JH, Jin JH, Ji IJ, An HJ, Kim JW, Lee GM. Proteomic Analysis of Host Cell Protein Dynamics in the Supernatant of Fc-Fusion Protein-Producing CHO DG44 and DUKX-B11 Cell Lines in Batch and Fed-Batch cultures. Biotechnology and Bioengineering. PMID 28627725 DOI: 10.1002/Bit.26360 |
0.37 |
|
| 2017 |
Baek E, Noh SM, Lee GM. Anti-Apoptosis Engineering for Improved Protein Production from CHO Cells. Methods in Molecular Biology (Clifton, N.J.). 1603: 71-85. PMID 28493124 DOI: 10.1007/978-1-4939-6972-2_5 |
0.396 |
|
| 2017 |
Park JH, Jin JH, Lim MS, An HJ, Kim JW, Lee GM. Proteomic Analysis of Host Cell Protein Dynamics in the Culture Supernatants of Antibody-Producing CHO Cells. Scientific Reports. 7: 44246. PMID 28281648 DOI: 10.1038/Srep44246 |
0.395 |
|
| 2017 |
Kallehauge TB, Li S, Pedersen LE, Ha TK, Ley D, Andersen MR, Kildegaard HF, Lee GM, Lewis NE. Ribosome profiling-guided depletion of an mRNA increases cell growth rate and protein secretion. Scientific Reports. 7: 40388. PMID 28091612 DOI: 10.1038/Srep40388 |
0.599 |
|
| 2016 |
Hansen HG, Pristovšek N, Kildegaard HF, Lee GM. Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions. Biotechnology Advances. PMID 27931938 DOI: 10.1016/j.biotechadv.2016.11.008 |
0.311 |
|
| 2016 |
Noh SM, Park JH, Lim MS, Kim JW, Lee GM. Reduction of ammonia and lactate through the coupling of glutamine synthetase selection and downregulation of lactate dehydrogenase-A in CHO cells. Applied Microbiology and Biotechnology. PMID 27704181 DOI: 10.1007/S00253-016-7876-Y |
0.495 |
|
| 2016 |
Yu DY, Noh SM, Lee GM. Limitations to the development of recombinant human embryonic kidney 293E cells using glutamine synthetase-mediated gene amplification: methionine sulfoximine resistance. Journal of Biotechnology. PMID 27288593 DOI: 10.1016/J.Jbiotec.2016.06.003 |
0.539 |
|
| 2016 |
Park JH, Lim MS, Woo JR, Kim JW, Lee GM. The Molecular Weight and Concentration of Dextran Sulfate Affect Cell Growth and Antibody Production in CHO Cell Cultures. Biotechnology Progress. PMID 27114230 DOI: 10.1002/Btpr.2287 |
0.521 |
|
| 2016 |
Baek E, Kim CL, Kim MG, Lee JS, Lee GM. Chemical inhibition of autophagy: Examining its potential to increase the specific productivity of recombinant CHO cell lines. Biotechnology and Bioengineering. PMID 26914152 DOI: 10.1002/Bit.25962 |
0.422 |
|
| 2016 |
Lee N, Shin J, Park J, Lee GM, Cho SH, Cho BK. Targeted gene deletion using DNA-free RNA-guided Cas9 nuclease accelerates adaptation of CHO cells to suspension culture. Acs Synthetic Biology. PMID 26854539 DOI: 10.1021/Acssynbio.5B00249 |
0.418 |
|
| 2016 |
Kim CL, Bang YL, Kim YS, Jang JW, Lee GM. Alleviation of proteolytic degradation of recombinant human bone morphogenetic protein-4 by repeated batch culture of Chinese hamster ovary cells Process Biochemistry. 51: 1078-1084. DOI: 10.1016/J.Procbio.2016.05.007 |
0.431 |
|
| 2016 |
Kim CL, Ha TK, Lee GM. Combinatorial treatment with lithium chloride enhances recombinant antibody production in transiently transfected CHO and HEK293E cells Biotechnology and Bioprocess Engineering. 21: 667-675. DOI: 10.1007/S12257-016-0434-8 |
0.432 |
|
| 2016 |
Lee S, Kim MG, Kim N, Heo WD, Lee GM. Heparan sulfate proteoglycan synthesis in CHO DG44 and HEK293 cells Biotechnology and Bioprocess Engineering. 21: 439-445. DOI: 10.1007/S12257-015-0688-6 |
0.507 |
|
| 2015 |
Park JH, Noh SM, Woo JR, Kim JW, Lee GM. Valeric acid induces cell cycle arrest at G1 phase in CHO cell cultures and improves recombinant antibody productivity. Biotechnology Journal. PMID 26663903 DOI: 10.1002/Biot.201500327 |
0.435 |
|
| 2015 |
Hansen HG, Nilsson CN, Lund AM, Kol S, Grav LM, Lundqvist M, Rockberg J, Lee GM, Andersen MR, Kildegaard HF. Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells. Scientific Reports. 5: 18016. PMID 26657798 DOI: 10.1038/Srep18016 |
0.478 |
|
| 2015 |
Lee JH, Kim YG, Lee GM. Effect of Bcl-xL overexpression on sialylation of Fc-fusion protein in recombinant Chinese hamster ovary cell cultures. Biotechnology Progress. 31: 1133-6. PMID 26018766 DOI: 10.1002/Btpr.2115 |
0.505 |
|
| 2015 |
Grav LM, Lee JS, Gerling S, Kallehauge TB, Hansen AH, Kol S, Lee GM, Pedersen LE, Kildegaard HF. One-step generation of triple knockout CHO cell lines using CRISPR/Cas9 and fluorescent enrichment. Biotechnology Journal. PMID 25864574 DOI: 10.1002/Biot.201500027 |
0.468 |
|
| 2015 |
Ha TK, Kim YG, Lee GM. Understanding of altered N-glycosylation-related gene expression in recombinant Chinese hamster ovary cells subjected to elevated ammonium concentration by digital mRNA counting. Biotechnology and Bioengineering. 112: 1583-93. PMID 25728222 DOI: 10.1002/Bit.25568 |
0.412 |
|
| 2015 |
Sathyamurthy M, Kim CL, Bang YL, Kim YS, Jang JW, Lee GM. Characterization and expression of proprotein convertases in CHO cells: Efficient proteolytic maturation of human bone morphogenetic protein-7. Biotechnology and Bioengineering. 112: 560-8. PMID 25219685 DOI: 10.1002/Bit.25458 |
0.446 |
|
| 2015 |
Min KH, Lee GM. Purification of TNFR-Fc produced in recombinant CHO cells: Characterization of product-related impurities Process Biochemistry. 50: 1313-1317. DOI: 10.1016/J.Procbio.2015.05.006 |
0.352 |
|
| 2015 |
Shin J, Lee N, Song Y, Park J, Kang TJ, Kim SC, Lee GM, Cho BK. Efficient CRISPR/Cas9-mediated multiplex genome editing in CHO cells via high-level sgRNA-Cas9 complex Biotechnology and Bioprocess Engineering. 20: 825-833. DOI: 10.1007/S12257-015-0233-7 |
0.36 |
|
| 2014 |
Ha TK, Kim YG, Lee GM. Effect of lithium chloride on the production and sialylation of Fc-fusion protein in Chinese hamster ovary cell culture. Applied Microbiology and Biotechnology. 98: 9239-48. PMID 25132065 DOI: 10.1007/S00253-014-6012-0 |
0.47 |
|
| 2014 |
Ha TK, Lee GM. Effect of glutamine substitution by TCA cycle intermediates on the production and sialylation of Fc-fusion protein in Chinese hamster ovary cell culture. Journal of Biotechnology. 180: 23-9. PMID 24721212 DOI: 10.1016/J.Jbiotec.2014.04.002 |
0.424 |
|
| 2014 |
Hong JK, Lee SM, Kim KY, Lee GM. Effect of sodium butyrate on the assembly, charge variants, and galactosylation of antibody produced in recombinant Chinese hamster ovary cells. Applied Microbiology and Biotechnology. 98: 5417-25. PMID 24557571 DOI: 10.1007/S00253-014-5596-8 |
0.432 |
|
| 2014 |
Seo JS, Min BS, Kim YJ, Cho JM, Baek E, Cho MS, Lee GM. Effect of glucose feeding on the glycosylation quality of antibody produced by a human cell line, F2N78, in fed-batch culture. Applied Microbiology and Biotechnology. 98: 3509-15. PMID 24384750 DOI: 10.1007/S00253-013-5462-0 |
0.356 |
|
| 2014 |
Lee SM, Kim YG, Lee EG, Lee GM. Digital mRNA profiling of N-glycosylation gene expression in recombinant Chinese hamster ovary cells treated with sodium butyrate. Journal of Biotechnology. 171: 56-60. PMID 24333461 DOI: 10.1016/J.Jbiotec.2013.12.001 |
0.368 |
|
| 2014 |
Kim WH, Kim YJ, Lee GM. Gadd45-induced cell cycle G2/M arrest for improved transient gene expression in Chinese hamster ovary cells Biotechnology and Bioprocess Engineering. 19: 386-393. DOI: 10.1007/S12257-014-0151-0 |
0.523 |
|
| 2013 |
Ha TK, Jeon MK, Yu da Y, Lee GM. Effect of Bcl-x(L) overexpression on lactate metabolism in chinese hamster ovary cells producing antibody. Biotechnology Progress. 29: 1594-8. PMID 24039207 DOI: 10.1002/Btpr.1805 |
0.455 |
|
| 2013 |
Kim YJ, Baek E, Lee JS, Lee GM. Autophagy and its implication in Chinese hamster ovary cell culture. Biotechnology Letters. 35: 1753-63. PMID 23881315 DOI: 10.1007/S10529-013-1276-5 |
0.488 |
|
| 2013 |
Seo JS, Kim YJ, Cho JM, Baek E, Lee GM. Effect of culture pH on recombinant antibody production by a new human cell line, F2N78, grown in suspension at 33.0 °C and 37.0 °C. Applied Microbiology and Biotechnology. 97: 5283-91. PMID 23553031 DOI: 10.1007/S00253-013-4849-2 |
0.49 |
|
| 2013 |
Lee JS, Ha TK, Park JH, Lee GM. Anti-cell death engineering of CHO cells: co-overexpression of Bcl-2 for apoptosis inhibition, Beclin-1 for autophagy induction. Biotechnology and Bioengineering. 110: 2195-207. PMID 23436561 DOI: 10.1002/Bit.24879 |
0.431 |
|
| 2013 |
Lee S, Lee GM. Bcl-2 overexpression in CHO cells improves polyethylenimine-mediated gene transfection Process Biochemistry. 48: 1436-1440. DOI: 10.1016/J.Procbio.2013.03.021 |
0.484 |
|
| 2013 |
Noh SM, Sathyamurthy M, Lee GM. Development of recombinant Chinese hamster ovary cell lines for therapeutic protein production Current Opinion in Chemical Engineering. 2: 391-397. DOI: 10.1016/J.Coche.2013.08.002 |
0.456 |
|
| 2012 |
Sathyamurthy M, Lee JS, Park JH, Kim YJ, Jeong JY, Jang JW, Lee GM. Overexpression of PACEsol improves BMP-7 processing in recombinant CHO cells. Journal of Biotechnology. 164: 336-9. PMID 23376616 DOI: 10.1016/J.Jbiotec.2013.01.012 |
0.454 |
|
| 2012 |
Lee JS, Ha TK, Lee SJ, Lee GM. Current state and perspectives on erythropoietin production. Applied Microbiology and Biotechnology. 95: 1405-16. PMID 22820523 DOI: 10.1007/S00253-012-4291-X |
0.433 |
|
| 2012 |
Lee JS, Kim YJ, Kim CL, Lee GM. Differential induction of autophagy in caspase-3/7 down-regulating and Bcl-2 overexpressing recombinant CHO cells subjected to sodium butyrate treatment. Journal of Biotechnology. 161: 34-41. PMID 22728390 DOI: 10.1016/J.Jbiotec.2012.05.011 |
0.401 |
|
| 2012 |
Lee JS, Lee GM. Rapamycin treatment inhibits CHO cell death in a serum-free suspension culture by autophagy induction. Biotechnology and Bioengineering. 109: 3093-102. PMID 22627923 DOI: 10.1002/Bit.24567 |
0.471 |
|
| 2012 |
Lee JS, Lee GM. Effect of sodium butyrate on autophagy and apoptosis in Chinese hamster ovary cells. Biotechnology Progress. 28: 349-57. PMID 22492702 DOI: 10.1002/Btpr.1512 |
0.403 |
|
| 2012 |
Kim JY, Kim YG, Lee GM. Differential in-gel electrophoresis (DIGE) analysis of CHO cells under hyperosmotic pressure: osmoprotective effect of glycine betaine addition. Biotechnology and Bioengineering. 109: 1395-403. PMID 22252946 DOI: 10.1002/Bit.24442 |
0.425 |
|
| 2012 |
Kim JY, Kim YG, Lee GM. CHO cells in biotechnology for production of recombinant proteins: current state and further potential. Applied Microbiology and Biotechnology. 93: 917-30. PMID 22159888 DOI: 10.1007/S00253-011-3758-5 |
0.502 |
|
| 2012 |
Lee JS, Lee GM. Monitoring of autophagy in Chinese hamster ovary cells using flow cytometry. Methods (San Diego, Calif.). 56: 375-82. PMID 22142658 DOI: 10.1016/J.Ymeth.2011.11.006 |
0.468 |
|
| 2012 |
Kim WH, Kim MS, Kim YG, Lee GM. Development of apoptosis-resistant CHO cell line expressing PyLT for the enhancement of transient antibody production Process Biochemistry. 47: 2557-2561. DOI: 10.1016/J.Procbio.2012.08.005 |
0.452 |
|
| 2012 |
Kim YG, Park B, Lee S, Ahn JO, Jung JK, Lee HW, Lee GM, Lee EG. Effect of mitochondrial and ER-targeted Bcl-2 overexpression on apoptosis in recombinant Chinese hamster ovary cells treated with sodium butyrate Process Biochemistry. 47: 2518-2522. DOI: 10.1016/J.Procbio.2012.06.021 |
0.329 |
|
| 2012 |
Lee JS, Lee GM. Estimation of autophagy pathway genes for autophagy induction: Overexpression of Atg9A does not induce autophagy in recombinant Chinese hamster ovary cells Biochemical Engineering Journal. 68: 221-226. DOI: 10.1016/J.Bej.2012.07.021 |
0.445 |
|
| 2012 |
Mohan C, Sathyamurthy M, Lee GM. A role of GADD153 in ER stress-induced apoptosis in recombinant chinese hamster ovary cells Biotechnology and Bioprocess Engineering. 17: 446-455. DOI: 10.1007/S12257-011-0653-Y |
0.415 |
|
| 2011 |
Park S, Han J, Kim W, Lee GM, Kim HS. Rapid selection of single cells with high antibody production rates by microwell array. Journal of Biotechnology. 156: 197-202. PMID 21925218 DOI: 10.1016/J.Jbiotec.2011.08.031 |
0.471 |
|
| 2011 |
Han YK, Ha TK, Kim YG, Lee GM. Bcl-x L overexpression delays the onset of autophagy and apoptosis in hyperosmotic recombinant Chinese hamster ovary cell cultures Journal of Biotechnology. 156: 52-55. PMID 21875625 DOI: 10.1016/J.Jbiotec.2011.07.032 |
0.388 |
|
| 2011 |
Jeon MK, Yu DY, Lee GM. Combinatorial engineering of ldh-a and bcl-2 for reducing lactate production and improving cell growth in dihydrofolate reductase-deficient Chinese hamster ovary cells Applied Microbiology and Biotechnology. 92: 779-790. PMID 21792592 DOI: 10.1007/S00253-011-3475-0 |
0.532 |
|
| 2011 |
Hong JK, Lee GM, Yoon SK. Growth factor withdrawal in combination with sodium butyrate addition extends culture longevity and enhances antibody production in CHO cells Journal of Biotechnology. 155: 225-231. PMID 21723342 DOI: 10.1016/J.Jbiotec.2011.06.020 |
0.499 |
|
| 2011 |
Hwang SJ, Yoon SK, Koh GY, Lee GM. Effects of culture temperature and pH on flag-tagged COMP angiopoietin-1 (FCA1) production from recombinant CHO cells: FCA1 aggregation. Applied Microbiology and Biotechnology. 91: 305-15. PMID 21509567 DOI: 10.1007/S00253-011-3266-7 |
0.395 |
|
| 2011 |
Han YK, Ha TK, Lee SJ, Lee JS, Lee GM. Autophagy and apoptosis of recombinant Chinese hamster ovary cells during fed-batch culture: Effect of nutrient supplementation Biotechnology and Bioengineering. 108: 2182-2192. PMID 21495016 DOI: 10.1002/Bit.23165 |
0.512 |
|
| 2011 |
Kim YG, Han YK, Kim JY, Lee EG, Lee HW, Lee GM. Effect of constitutively active ras overexpression on cell growth in recombinant chinese hamster ovary cells Biotechnology Progress. 27: 577-580. PMID 21438179 DOI: 10.1002/Btpr.567 |
0.339 |
|
| 2011 |
Hwang SJ, Jeon CJ, Cho SM, Lee GM, Yoon SK. Effect of chemical chaperone addition on production and aggregation of recombinant flag-tagged COMP-angiopoietin 1 in Chinese hamster ovary cells. Biotechnology Progress. 27: 587-91. PMID 21425253 DOI: 10.1002/Btpr.579 |
0.368 |
|
| 2011 |
Kim JY, Kim YG, Han YK, Choi HS, Kim YH, Lee GM. Proteomic understanding of intracellular responses of recombinant Chinese hamster ovary cells cultivated in serum-free medium supplemented with hydrolysates. Applied Microbiology and Biotechnology. 89: 1917-28. PMID 21286710 DOI: 10.1007/S00253-011-3106-9 |
0.424 |
|
| 2011 |
Kim YG, Kim JY, Park B, Ahn JO, Jung JK, Lee HW, Lee GM, Lee EG. Effect of Bcl-xL overexpression on erythropoietin production in recombinant Chinese hamster ovary cells treated with dimethyl sulfoxide Process Biochemistry. 46: 2201-2204. DOI: 10.1016/J.Procbio.2011.07.017 |
0.446 |
|
| 2011 |
Baik JY, Ha TK, Kim YH, Lee GM. Proteomic understanding of intracellular responses of recombinant chinese hamster ovary cells adapted to grow in serum-free suspension culture Biotechnology Progress. 27: 1680-1688. DOI: 10.1002/Btpr.685 |
0.451 |
|
| 2010 |
Jeon MK, Lim JB, Lee GM. Development of a serum-free medium for in vitro expansion of human cytotoxic T lymphocytes using a statistical design Bmc Biotechnology. 10. PMID 20854694 DOI: 10.1186/1472-6750-10-70 |
0.376 |
|
| 2010 |
Mohan C, Lee GM. Effect of inducible co-overexpression of protein disulfide isomerase and endoplasmic reticulum oxidoreductase on the specific antibody productivity of recombinant chinese hamster ovary cells Biotechnology and Bioengineering. 107: 337-346. PMID 20506311 DOI: 10.1002/Bit.22781 |
0.417 |
|
| 2010 |
Lee JS, Park HJ, Kim YH, Lee GM. Protein reference mapping of dihydrofolate reductase-deficient CHO DG44 cell lines using 2-dimensional electrophoresis Proteomics. 10: 2292-2302. PMID 20391528 DOI: 10.1002/Pmic.200900430 |
0.405 |
|
| 2010 |
Koo J, Kim KI, Min BH, Lee GM. Differential protein expression in human articular chondrocytes expanded in serum-free media of different medium osmolalities by DIGE. Journal of Proteome Research. 9: 2480-7. PMID 20329760 DOI: 10.1021/Pr100136Q |
0.38 |
|
| 2010 |
Han YK, Kim YG, Kim JY, Lee GM. Hyperosmotic stress induces autophagy and apoptosis in recombinant chinese hamster ovary cell culture Biotechnology and Bioengineering. 105: 1187-1192. PMID 20014438 DOI: 10.1002/Bit.22643 |
0.449 |
|
| 2010 |
Koo J, Kim KI, Min BH, Lee GM. Controlling medium osmolality improves the expansion of human articular chondrocytes in serum-free media. Tissue Engineering. Part C, Methods. 16: 957-63. PMID 20001269 DOI: 10.1089/Ten.Tec.2009.0525 |
0.392 |
|
| 2010 |
Kim JY, Kim YG, Baik JY, Joo EJ, Kim YH, Lee GM. A proteomic approach for identifying cellular proteins interacting with erythropoietin in recombinant Chinese hamster ovary cells Biotechnology Progress. 26: 246-251. PMID 19918894 DOI: 10.1002/Btpr.323 |
0.362 |
|
| 2010 |
Baik JY, Lee GM. A DIGE approach for the assessment of differential expression of the CHO proteome under sodium butyrate addition: Effect of Bcl-xL overexpression Biotechnology and Bioengineering. 105: 358-367. PMID 19739093 DOI: 10.1002/Bit.22534 |
0.367 |
|
| 2009 |
Kim YG, Kim JY, Lee GM. Effect of XIAP overexpression on sodium butyrate-induced apoptosis in recombinant Chinese hamster ovary cells producing erythropoietin Journal of Biotechnology. 144: 299-303. PMID 19799944 DOI: 10.1016/J.Jbiotec.2009.09.016 |
0.367 |
|
| 2009 |
Han YK, Koo TY, Lee GM. Enhanced interferon-β production by CHO cells through elevated osmolality and reduced culture temperature Biotechnology Progress. 25: 1440-1447. PMID 19572287 DOI: 10.1002/Btpr.234 |
0.327 |
|
| 2009 |
Ju HK, Hwang SJ, Jeon CJ, Lee GM, Yoon SK. Use of NaCl prevents aggregation of recombinant COMP-angiopoietin-1 in Chinese hamster ovary cells. Journal of Biotechnology. 143: 145-50. PMID 19559063 DOI: 10.1016/J.Jbiotec.2009.06.017 |
0.4 |
|
| 2009 |
Kim WH, Kim JS, Yoon Y, Lee GM. Effect of Ca2+ and Mg2+ concentration in culture medium on the activation of recombinant factor IX produced in Chinese hamster ovary cells Journal of Biotechnology. 142: 275-278. PMID 19523499 DOI: 10.1016/J.Jbiotec.2009.06.001 |
0.331 |
|
| 2009 |
Kim YG, Kim JY, Mohan C, Lee GM. Effect of Bcl-xL overexpression on apoptosis and autophagy in recombinant Chinese hamster ovary cells under nutrient-deprived condition Biotechnology and Bioengineering. 103: 757-766. PMID 19266576 DOI: 10.1002/Bit.22298 |
0.352 |
|
| 2009 |
Kim SH, Lee GM. Development of serum-free medium supplemented with hydrolysates for the production of therapeutic antibodies in CHO cell cultures using design of experiments Applied Microbiology and Biotechnology. 83: 639-648. PMID 19266194 DOI: 10.1007/S00253-009-1903-1 |
0.487 |
|
| 2009 |
Kim YG, Lee GM. Bcl-xL overexpression does not enhance specific erythropoietin productivity of recombinant CHO cells grown at 33°C and 37°C Biotechnology Progress. 25: 252-256. PMID 19224599 DOI: 10.1002/Btpr.91 |
0.459 |
|
| 2009 |
Jang C, Koh YJ, Lim NK, Kang HJ, Kim DH, Park SK, Lee GM, Jeon CJ, Koh GY. Angiopoietin-2 exocytosis is stimulated by sphingosine-1-phosphate in human blood and lymphatic endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 29: 401-7. PMID 19112163 DOI: 10.1161/Atvbaha.108.172676 |
0.311 |
|
| 2009 |
Hwang SO, Lee GM. Effect of Akt overexpression on programmed cell death in antibody-producing Chinese hamster ovary cells Journal of Biotechnology. 139: 89-94. PMID 18983878 DOI: 10.1016/J.Jbiotec.2008.09.008 |
0.489 |
|
| 2009 |
Mohan C, Lee GM. Calnexin overexpression sensitizes recombinant CHO cells to apoptosis induced by sodium butyrate treatment Cell Stress and Chaperones. 14: 49-60. PMID 18663604 DOI: 10.1007/S12192-008-0054-0 |
0.463 |
|
| 2009 |
Kim WH, Kim JS, Yoon Y, Lee GM. Corrigendum to "Effect of Ca2+ and Mg2+ concentration in culture medium on the activation of recombinant factor IX produced in Chinese hamster ovary cells" [J. Biotechnol. 142 (2009) 275-278] (DOI:10.1016/j.jbiotec.2009.06.001) Journal of Biotechnology. 144: 342. DOI: 10.1016/J.Jbiotec.2009.09.011 |
0.368 |
|
| 2009 |
Kim KS, Kim MS, Moon JH, Jeong MS, Kim J, Lee GM, Myung PK, Hong HJ. Enhancement of recombinant antibody production in HEK 293E cells by WPRE Biotechnology and Bioprocess Engineering. 14: 633-638. DOI: 10.1007/S12257-008-0221-2 |
0.423 |
|
| 2008 |
Kim MS, Lee GM. Use of Flp-mediated cassette exchange in the development of a CHO cell line stably producing erythropoietin Journal of Microbiology and Biotechnology. 18: 1342-1351. PMID 18667865 |
0.321 |
|
| 2008 |
Hwang SJ, Kim SH, Kim HZ, Steinmetz MO, Koh GY, Lee GM. High-level expression and purification of a designed angiopoietin-1 chimeric protein, COMP-Ang1, produced in Chinese hamster ovary cells. The Protein Journal. 27: 319-26. PMID 18465215 DOI: 10.1007/S10930-008-9140-5 |
0.444 |
|
| 2008 |
Mohan C, Kim YG, Koo J, Lee GM. Assessment of cell engineering strategies for improved therapeutic protein production in CHO cells Biotechnology Journal. 3: 624-630. PMID 18293320 DOI: 10.1002/Biot.200700249 |
0.477 |
|
| 2008 |
Baik JY, Joo EJ, Kim YH, Lee GM. Limitations to the comparative proteomic analysis of thrombopoietin producing Chinese hamster ovary cells treated with sodium butyrate Journal of Biotechnology. 133: 461-468. PMID 18164778 DOI: 10.1016/J.Jbiotec.2007.11.008 |
0.357 |
|
| 2008 |
Hwang SO, Lee GM. Autophagy and apoptosis in Chinese hamster ovary cell culture Autophagy. 4: 70-72. PMID 17932458 DOI: 10.4161/Auto.5065 |
0.5 |
|
| 2008 |
Sun OH, Lee GM. Nutrient deprivation induces autophagy as well as apoptosis in Chinese hamster ovary cell culture Biotechnology and Bioengineering. 99: 678-685. PMID 17680685 DOI: 10.1002/Bit.21589 |
0.499 |
|
| 2008 |
Sung YH, Lee GM. Enhanced Human Thrombopoietin Production by Sodium Butyrate Addition to Serum-Free Suspension Culture of Bcl-2 Overexpressing CHO Cells Biotechnology Progress. 21: 50-57. PMID 15903240 DOI: 10.1021/Bp049892N |
0.522 |
|
| 2008 |
Lee SJ, Lee GM. Effect of BCL-2 overexpression on HEK293 EBNA cells in transient gene expression system Journal of Biotechnology. 136. DOI: 10.1016/J.Jbiotec.2008.07.296 |
0.386 |
|
| 2008 |
Lee GM. Assessment of cell engineering strategies for improved foreign protein production in cho cells Journal of Biotechnology. 136. DOI: 10.1016/J.Jbiotec.2008.07.275 |
0.454 |
|
| 2008 |
Jeon MK, Lim JB, Lee GM. A method using allogenous dendritic cells of the same HLA-A type to stimulate CMV specific cytotoxic T lymohocytes Journal of Biotechnology. 136. DOI: 10.1016/J.Jbiotec.2008.07.263 |
0.315 |
|
| 2008 |
Kim MS, Kim WH, Lee GM. Characterization of site-specific recombination mediated by Cre recombinase during the development of erythropoietin producing CHO cell lines Biotechnology and Bioprocess Engineering. 13: 418-423. DOI: 10.1007/S12257-008-0151-Z |
0.403 |
|
| 2007 |
Jeon MK, Lee GM. Correlation between enhancing effect of sodium butyrate on specific productivity and mRNA transcription level in recombinant Chinese hamster ovary cells producing antibody Journal of Microbiology and Biotechnology. 17: 1036-1040. PMID 18050924 |
0.387 |
|
| 2007 |
Sung YH, Lee JS, Park SH, Koo J, Lee GM. Influence of co-down-regulation of caspase-3 and caspase-7 by siRNAs on sodium butyrate-induced apoptotic cell death of Chinese hamster ovary cells producing thrombopoietin Metabolic Engineering. 9: 452-464. PMID 17892962 DOI: 10.1016/j.ymben.2007.08.001 |
0.303 |
|
| 2007 |
Hwang SJ, Kim HZ, Koh GY, Lee GM. Expression and purification of recombinant human angiopoietin-1 produced in Chinese hamster ovary cells. In Vitro Cellular & Developmental Biology. Animal. 43: 162-7. PMID 17619940 DOI: 10.1007/S11626-007-9037-1 |
0.506 |
|
| 2007 |
Kim SH, Lee GM. Functional expression of human pyruvate carboxylase for reduced lactic acid formation of Chinese hamster ovary cells (DG44) Applied Microbiology and Biotechnology. 76: 659-665. PMID 17583807 DOI: 10.1007/S00253-007-1041-6 |
0.53 |
|
| 2007 |
Mohan C, Soon HP, Joo YC, Lee GM. Effect of doxycycline-regulated protein disulfide isomerase expression on the specific productivity of recombinant CHO cells: Thrombopoietin and antibody Biotechnology and Bioengineering. 98: 611-615. PMID 17421043 DOI: 10.1002/Bit.21453 |
0.484 |
|
| 2007 |
Hong JK, Kim YG, Yoon SK, Lee GM. Down-regulation of cold-inducible RNA-binding protein does not improve hypothermic growth of Chinese hamster ovary cells producing erythropoietin Metabolic Engineering. 9: 208-216. PMID 17239640 DOI: 10.1016/J.Ymben.2006.11.003 |
0.452 |
|
| 2007 |
Kim SH, Lee GM. Down-regulation of lactate dehydrogenase-A by siRNAs for reduced lactic acid formation of Chinese hamster ovary cells producing thrombopoietin Applied Microbiology and Biotechnology. 74: 152-159. PMID 17086415 DOI: 10.1007/S00253-006-0654-5 |
0.512 |
|
| 2006 |
Jun SC, Kim MS, Hong HJ, Lee GM. Limitations to the development of humanized antibody producing Chinese hamster ovary cells using glutamine synthetase-mediated gene amplification. Biotechnology Progress. 22: 770-80. PMID 16739961 DOI: 10.1021/Bp060004T |
0.416 |
|
| 2006 |
Kwon RJ, Kim SK, Lee SI, Hwang SJ, Lee GM, Kim JS, Seol W. Artificial transcription factors increase production of recombinant antibodies in Chinese hamster ovary cells. Biotechnology Letters. 28: 9-15. PMID 16369868 DOI: 10.1007/S10529-005-4680-7 |
0.457 |
|
| 2006 |
Yoon SK, Hong JK, Choo SH, Song JY, Park HW, Lee GM. Adaptation of Chinese hamster ovary cells to low culture temperature: Cell growth and recombinant protein production Journal of Biotechnology. 122: 463-472. PMID 16253368 DOI: 10.1016/J.Jbiotec.2005.09.010 |
0.5 |
|
| 2006 |
Baik JY, Lee MS, An SR, Yoon SK, Joo EJ, Kim YH, Park HW, Lee GM. Initial transcriptome and proteome analyses of low culture temperature-induced expression in CHO cells producing erythropoietin Biotechnology and Bioengineering. 93: 361-371. PMID 16187333 DOI: 10.1002/Bit.20717 |
0.392 |
|
| 2006 |
Yoon SK, Kim SH, Song JY, Lee GM. Biphasic culture strategy for enhancing volumetric erythropoietin productivity of Chinese hamster ovary cells Enzyme and Microbial Technology. 39: 362-365. DOI: 10.1016/J.Enzmictec.2005.11.029 |
0.416 |
|
| 2005 |
Sung YH, Hwang SJ, Lee GM. Influence of down-regulation of caspase-3 by siRNAs on sodium-butyrate-induced apoptotic cell death of Chinese hamster ovary cells producing thrombopoietin. Metabolic Engineering. 7: 457-66. PMID 16169764 DOI: 10.1016/J.Ymben.2005.08.001 |
0.444 |
|
| 2005 |
Jun SC, Kim MS, Baik JY, Hwang SO, Lee GM. Selection strategies for the establishment of recombinant Chinese hamster ovary cell line with dihydrofolate reductase-mediated gene amplification. Applied Microbiology and Biotechnology. 69: 162-9. PMID 15818475 DOI: 10.1007/S00253-005-1972-8 |
0.42 |
|
| 2005 |
Hwang SJ, Choi HH, Kim KT, Hong HJ, Koh GY, Lee GM. Expression and purification of recombinant human angiopoietin-2 produced in Chinese hamster ovary cells. Protein Expression and Purification. 39: 175-83. PMID 15642468 DOI: 10.1016/J.Pep.2004.09.005 |
0.461 |
|
| 2005 |
Yoon SK, Choi SL, Song JY, Lee GM. Effect of culture pH on erythropoietin production by Chinese hamster ovary cells grown in suspension at 32.5 and 37.0 degrees C. Biotechnology and Bioengineering. 89: 345-356. PMID 15625678 DOI: 10.1002/Bit.20353 |
0.374 |
|
| 2005 |
Ryu JH, Kim MS, Lee GM, Choi CY, Kim BS. The enhancement of recombinant protein production by polymer nanospheres in cell suspension culture Biomaterials. 26: 2173-2181. PMID 15576193 DOI: 10.1016/J.Biomaterials.2004.06.017 |
0.514 |
|
| 2004 |
Yoon SK, Hwang SO, Lee GM. Enhancing Effect of Low Culture Temperature on Specific Antibody Productivity of Recombinant Chinese Hamster Ovary Cells: Clonal Variation Biotechnology Progress. 20: 1683-1688. PMID 15575699 DOI: 10.1021/Bp049847F |
0.404 |
|
| 2004 |
Sung YH, Song YJ, Lim SW, Chung JY, Lee GM. Effect of sodium butyrate on the production, heterogeneity and biological activity of human thrombopoietin by recombinant Chinese hamster ovary cells. Journal of Biotechnology. 112: 323-335. PMID 15313009 DOI: 10.1016/J.Jbiotec.2004.05.003 |
0.459 |
|
| 2004 |
Yoon SK, Hong JK, Lee GM. Effect of simultaneous application of stressful culture conditions on specific productivity and heterogeneity of erythropoietin in chinese hamster ovary cells Biotechnology Progress. 20: 1293-1296. PMID 15296466 DOI: 10.1021/Bp034382Z |
0.369 |
|
| 2004 |
Park MT, Hwang SJ, Lee GM. Flow cytometric application of helper adenovirus (HAd) containing GFP gene flanked by two parallel loxP sites to evaluation of 293 cre-complementing cell line and monitoring of HAd in Gutless Ad production. Biotechnology Progress. 20: 913-20. PMID 15176899 DOI: 10.1021/Bp034248E |
0.4 |
|
| 2004 |
Park MT, Lee MS, Kim SH, Jo EC, Lee GM. Influence of culture passages on growth kinetics and adenovirus vector production for gene therapy in monolayer and suspension cultures of HEK 293 cells. Applied Microbiology and Biotechnology. 65: 553-8. PMID 15168091 DOI: 10.1007/S00253-004-1617-3 |
0.469 |
|
| 2004 |
Cho CH, Kammerer RA, Lee HJ, Yasunaga K, Kim KT, Choi HH, Kim W, Kim SH, Park SK, Lee GM, Koh GY. Designed angiopoietin-1 variant, COMP-Ang1, protects against radiation-induced endothelial cell apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 101: 5553-8. PMID 15060280 DOI: 10.1073/Pnas.0307575101 |
0.335 |
|
| 2004 |
Cho CH, Kammerer RA, Lee HJ, Steinmetz MO, Ryu YS, Lee SH, Yasunaga K, Kim KT, Kim I, Choi HH, Kim W, Kim SH, Park SK, Lee GM, Koh GY. COMP-Ang1: a designed angiopoietin-1 variant with nonleaky angiogenic activity. Proceedings of the National Academy of Sciences of the United States of America. 101: 5547-52. PMID 15060279 DOI: 10.1073/Pnas.0307574101 |
0.304 |
|
| 2004 |
Chung JY, Lim SW, Hong YJ, Hwang SO, Lee GM. Effect of doxycycline‐regulated calnexin and calreticulin expression on specific thrombopoietin productivity of recombinant chinese hamster ovary cells Biotechnology and Bioengineering. 85: 539-546. PMID 14760694 DOI: 10.1002/Bit.10919 |
0.492 |
|
| 2004 |
Lee MS, Kim KW, Kim YH, Lee GM. Proteome analysis of antibody-expressing CHO cells in response to hyperosmotic pressure. Biotechnology Progress. 19: 1734-41. PMID 14656149 DOI: 10.1021/Bp034093A |
0.435 |
|
| 2004 |
Yoon SK, Kim SH, Lee GM. Effect of low culture temperature on specific productivity and transcription level of anti-4-1BB antibody in recombinant Chinese hamster ovary cells. Biotechnology Progress. 19: 1383-6. PMID 12892507 DOI: 10.1021/Bp034051M |
0.515 |
|
| 2004 |
Sung Y, Lim S, Chung J, Lee G. Yeast hydrolysate as a low-cost additive to serum-free medium for the production of human thrombopoietin in suspension cultures of Chinese hamster ovary cells. Applied Microbiology and Biotechnology. 63: 527-536. PMID 12856163 DOI: 10.1007/S00253-003-1389-1 |
0.468 |
|
| 2003 |
Lee SK, Lee GM. Development of apoptosis‐resistant dihydrofolate reductase‐deficient Chinese hamster ovary cell line Biotechnology and Bioengineering. 82: 872-876. PMID 12701155 DOI: 10.1002/Bit.10633 |
0.526 |
|
| 2003 |
Yoon SK, Song JY, Lee GM. Effect of low culture temperature on specific productivity, transcription level, and heterogeneity of erythropoietin in Chinese hamster ovary cells Biotechnology and Bioengineering. 82: 289-298. PMID 12599255 DOI: 10.1002/Bit.10566 |
0.437 |
|
| 2003 |
Hwang SO, Chung JY, Lee GM. Effect of doxycycline-regulated ERp57 expression on specific thrombopoietin productivity of recombinant CHO cells. Biotechnology Progress. 19: 179-184. PMID 12573023 DOI: 10.1021/Bp025578M |
0.469 |
|
| 2002 |
Kim MS, Kim NS, Sung YH, Lee GM. Biphasic culture strategy based on hyperosmotic pressure for improved humanized antibody production in Chinese hamster ovary cell culture. In Vitro Cellular & Developmental Biology – Animal. 38: 314-319. PMID 12513118 DOI: 10.1290/1071-2690(2002)038<0314:Bcsboh>2.0.Co;2 |
0.501 |
|
| 2002 |
Kim NS, Lee GM. Response of recombinant Chinese hamster ovary cells to hyperosmotic pressure: effect of Bcl-2 overexpression. Journal of Biotechnology. 95: 237-248. PMID 12007864 DOI: 10.1016/S0168-1656(02)00011-1 |
0.471 |
|
| 2002 |
Lee GM, Fong SS, Oh DJ, Francis K, Palsson BO. Characterization and efficacy of PKH26 as a probe to study the replication history of the human hematopoietic KG1a progenitor cell line. In Vitro Cellular & Developmental Biology. Animal. 38: 90-6. PMID 11929001 DOI: 10.1290/1071-2690(2002)038<0090:Caeopa>2.0.Co;2 |
0.756 |
|
| 2002 |
Kim NS, Lee GM. Inhibition of sodium butyrate‐induced apoptosis in recombinant Chinese hamster ovary cells by constitutively expressing antisense RNA of caspase‐3 Biotechnology and Bioengineering. 78: 217-228. PMID 11870612 DOI: 10.1002/Bit.10191 |
0.516 |
|
| 2002 |
Francis K, Lee GM, Palsson BO. Characterization of the KG1a cell line for use in a cell migration based screening assay Biotechnology and Bioprocess Engineering. 7: 178-184. DOI: 10.1007/Bf02932916 |
0.702 |
|
| 2001 |
Lee MS, Lee GM. Effect of hypoosmotic pressure on cell growth and antibody production in recombinant Chinese hamster ovary cell culture Cytotechnology. 36: 61-69. PMID 19003316 DOI: 10.1023/A:1014032701800 |
0.443 |
|
| 2001 |
Ryu JS, Lee MS, Lee GM. Effects of cloned gene dosage on the response of recombinant CHO cells to hyperosmotic pressure in regard to cell growth and antibody production. Biotechnology Progress. 17: 993-999. PMID 11735431 DOI: 10.1021/Bp010116E |
0.507 |
|
| 2001 |
Kim NS, Lee GM. Overexpression of bcl-2 inhibits sodium butyrate-induced apoptosis in Chinese hamster ovary cells resulting in enhanced humanized antibody production. Biotechnology and Bioengineering. 71: 184-93. PMID 11291028 DOI: 10.1002/1097-0290(2000)71:3<184::Aid-Bit1008>3.0.Co;2-W |
0.506 |
|
| 2001 |
Kim NS, Byun TH, Lee GM. Key determinants in the occurrence of clonal variation in humanized antibody expression of cho cells during dihydrofolate reductase mediated gene amplification. Biotechnology Progress. 17: 69-75. PMID 11170482 DOI: 10.1021/Bp000144H |
0.36 |
|
| 2001 |
Kim TK, Chung JY, Sung YH, Lee GM. Relationship between Cell Size and Specific Thrombopoietin Productivity in Chinese Hamster Ovary Cells during Dihydrofolate Reductase-mediated Gene Amplification Biotechnology and Bioprocess Engineering. 6: 332-336. DOI: 10.1007/Bf02933001 |
0.5 |
|
| 2000 |
Kang S, Kim B, Lee GM. Justification of continuous packed-bed reactor for retroviral vector production from amphotropic ΨCRIP murine producer cell Cytotechnology. 34: 151-158. PMID 19003389 DOI: 10.1023/A:1008120313175 |
0.45 |
|
| 2000 |
Kim JH, Bae SW, Hong HJ, Lee GM. Decreased chimeric antibody productivity of KR12H-1 transfectoma during long-term culture results from decreased antibody gene copy number. Biotechnology and Bioengineering. 51: 479-487. PMID 18629800 DOI: 10.1002/(Sici)1097-0290(19960820)51:4<479::Aid-Bit11>3.0.Co;2-D |
0.382 |
|
| 2000 |
Chung JY, Kim TK, Lee GM. Morphological Selection of Parental Chinese Hamster Ovary Cell Clones Exhibiting High-Level Expression of Recombinant Protein Biotechniques. 29: 768-774. PMID 11056806 DOI: 10.2144/00294St02 |
0.423 |
|
| 2000 |
Kim TK, Ryu JS, Chung JY, Kim MS, Lee GM. Osmoprotective effect of glycine betaine on thrombopoietin production in hyperosmotic Chinese hamster ovary cell culture: clonal variations. Biotechnology Progress. 16: 775-781. PMID 11027169 DOI: 10.1021/Bp000106Y |
0.47 |
|
| 2000 |
Ryu JS, Kim TK, Chung JY, Lee GM. Osmoprotective effect of glycine betaine on foreign protein production in hyperosmotic recombinant Chinese hamster ovary cell cultures differs among cell lines Biotechnology and Bioengineering. 70: 167-175. PMID 10972928 DOI: 10.1002/1097-0290(20001020)70:2<167::Aid-Bit6>3.0.Co;2-P |
0.542 |
|
| 2000 |
Oh DJ, Martinez AR, Lee GM, Francis K, Palsson BO. Intercellular adhesion can be visualized using fluorescently labeled fibrosarcoma HT1080 cells cocultured with hematopoietic cell lines or CD34(+) enriched human mobilized peripheral blood cells. Cytometry. 40: 119-25. PMID 10805931 DOI: 10.1002/(Sici)1097-0320(20000601)40:2<119::Aid-Cyto5>3.0.Co;2-P |
0.704 |
|
| 2000 |
Oh DJ, Martinez AR, Lee GM, Francis K, Palsson BO. Extension of osmolality-induced podia is observed from fluorescently labeled hematopoietic cell lines in hyperosmotic medium. Cytometry. 40: 109-18. PMID 10805930 DOI: 10.1002/(Sici)1097-0320(20000601)40:2<109::Aid-Cyto4>3.0.Co;2-V |
0.7 |
|
| 2000 |
Lee GM, Fong S, Francis K, Oh DJ, Palsson BO. In situ labeling of adherent cells with PKH26. In Vitro Cellular & Developmental Biology. Animal. 36: 4-6. PMID 10691033 DOI: 10.1290/1071-2690(2000)036<0004:Isloac>2.0.Co;2 |
0.741 |
|
| 2000 |
Park M, Lee G. Rapid titer assay of adenovirus containing green fluorescent protein gene using flow cytometric analysis Bioprocess Engineering. 22: 403-406. DOI: 10.1007/S004490050751 |
0.33 |
|
| 1999 |
Kim EJ, Kim NS, Lee GM. Development of a serum-free medium for dihydrofolate reductase-deficient Chinese hamster ovary cells (DG44) using a statistical design: Beneficial effect of weaning of cells In Vitro Cellular and Developmental Biology - Animal. 35: 178-182. PMID 10478796 DOI: 10.1007/S11626-999-0024-6 |
0.496 |
|
| 1999 |
Oh DJ, Lee GM, Francis K, Palsson BO. Phototoxicity of the fluorescent membrane dyes PKH2 and PKH26 on the human hematopoietic KG1a progenitor cell line. Cytometry. 36: 312-8. PMID 10404146 DOI: 10.1002/(Sici)1097-0320(19990801)36:4<312::Aid-Cyto5>3.0.Co;2-V |
0.69 |
|
| 1999 |
Lee GM, Kim EJ, Kim NS, Yoon SK, Ahn YH, Song JY. Development of a serum-free medium for the production of erythropoietin by suspension culture of recombinant Chinese hamster ovary cells using a statistical design. Journal of Biotechnology. 69: 85-93. PMID 10361720 DOI: 10.1016/S0168-1656(99)00004-8 |
0.449 |
|
| 1999 |
Ryu JS, Lee GM. Application of hypoosmolar medium to fed-batch culture of hybridoma cells for improvement of culture longevity. Biotechnology and Bioengineering. 62: 120-123. PMID 10099520 DOI: 10.1002/(Sici)1097-0290(19990105)62:1<120::Aid-Bit14>3.0.Co;2-R |
0.418 |
|
| 1998 |
Kim NS, Kim SJ, Lee GM. Clonal variability within dihydrofolate reductase-mediated gene amplified Chinese hamster ovary cells: stability in the absence of selective pressure. Biotechnology and Bioengineering. 60: 679-688. PMID 10099478 DOI: 10.1002/(Sici)1097-0290(19981220)60:6<679::Aid-Bit5>3.0.Co;2-Q |
0.494 |
|
| 1998 |
Kim SJ, Kim NS, Ryu CJ, Hong HJ, Lee GM. Characterization of chimeric antibody producing CHO cells in the course of dihydrofolate reductase-mediated gene amplification and their stability in the absence of selective pressure Biotechnology and Bioengineering. 58: 73-84. PMID 10099263 DOI: 10.1002/(Sici)1097-0290(19980405)58:1<73::Aid-Bit8>3.0.Co;2-R |
0.453 |
|
| 1998 |
Kim EJ, Kim NS, Lee GM. Development of a serum-free medium for the production of humanized antibody from Chinese hamster ovary cells using a statistical design In Vitro Cellular and Developmental Biology - Animal. 34: 757-761. PMID 9870524 DOI: 10.1007/S11626-998-0029-6 |
0.476 |
|
| 1998 |
Lee GM, Choi JH, Jun SC, Palsson BO. Temperature significantly affects retroviral vector production and deactivation rates, and thereby determines retroviral titers Bioprocess Engineering. 19: 343. DOI: 10.1007/S004490050530 |
0.534 |
|
| 1997 |
Ryu JS, Lee GM. Effect Of Hypoosmotic Stress On Hybridoma Cell Growth And Antibody Production Biotechnology and Bioengineering. 55: 565-570. PMID 18636524 DOI: 10.1002/(Sici)1097-0290(19970805)55:3<565::Aid-Bit14>3.0.Co;2-F |
0.421 |
|
| 1997 |
Ryu J, Lee G. Influence of hyperosmolar basal media on hybridoma cell growth and antibody production Bioprocess Engineering. 16: 305-310. DOI: 10.1007/S004490050327 |
0.467 |
|
| 1997 |
Choi JH, Jun SC, Lee GM. Effect of serum concentration on retroviral vector production from the amphotropic ψCRIP murine producer cells Bioprocess Engineering. 17: 349-353. DOI: 10.1007/Pl00008969 |
0.47 |
|
| 1996 |
Rhee S, Lee G, Lee ST. Influence of a supplementary carbon source on biodegradation of pyridine by freely suspended and immobilized Pimelobacter sp Applied Microbiology and Biotechnology. 44: 816-822. PMID 8867640 DOI: 10.1007/Bf00178624 |
0.411 |
|
| 1996 |
Bae SW, Lee GM. Influence of fluorescent antibody probe specificity on flow cytometric analysis of antibody-producing cells Journal of Immunological Methods. 189: 83-88. PMID 8576583 DOI: 10.1016/0022-1759(95)00236-7 |
0.321 |
|
| 1996 |
Lee GM, Kim JH, Lee HG. Flow cytometric analysis of antibody producing cells using double immunofluorescent staining Biotechnology Techniques. 10: 615-620. DOI: 10.1007/Bf00157372 |
0.363 |
|
| 1995 |
Jun SC, Lee GM, Chang SH, Kim JH. Effect of serum type and concentration on the expression ofβ-galactosidase in recombinant vaccinia virus infected HeLa S3 cells. Cytotechnology. 19: 153-9. PMID 22359015 DOI: 10.1007/Bf00749770 |
0.344 |
|
| 1995 |
Choi SK, Chang HN, Lee GM, Kim IH, Oh DJ. High cell density perfusion cultures of anchorage-dependent Vero cells in a depth filter perfusion system. Cytotechnology. 17: 173-183. PMID 22358557 DOI: 10.1007/Bf00749655 |
0.462 |
|
| 1995 |
Bae SW, Hong HJ, Lee GM. Stability of transfectomas producing chimeric antibody against the pre-S2 surface antigen of hepatitis B virus during a long-term culture. Biotechnology and Bioengineering. 47: 243-251. PMID 18623398 DOI: 10.1002/Bit.260470216 |
0.356 |
|
| 1995 |
Kim SJ, Han BK, Lee GM. Feasibility study on the use of calcium alginate-entrapped hybridoma cells for IgM production Bioprocess Engineering. 12: 65-70. DOI: 10.1007/Bf01112995 |
0.452 |
|
| 1995 |
Park SY, Lee GM. Feasibility study on the use of hyperosmolar medium for improved antibody production of hybridoma cells in a long-term, repeated-fed batch culture Bioprocess Engineering. 13: 79-86. DOI: 10.1007/Bf00420433 |
0.452 |
|
| 1995 |
Lee GM, Park SY. Enhanced specific antibody productivity of hybridomas resulting from hyperosmotic stress is cell line-specific Biotechnology Letters. 17: 145-150. DOI: 10.1007/Bf00127978 |
0.465 |
|
| 1995 |
Park SY, Lee GM. Enhancement of monoclonal antibody production by immobilized hybridoma cell culture with hyperosmolar medium Biotechnology and Bioengineering. 48: 699-705. DOI: 10.1002/Bit.260480618 |
0.543 |
|
| 1994 |
Levee MG, Lee GM, Paek SH, Palsson BO. Microencapsulated human bone marrow cultures: a potential culture system for the clonal outgrowth of hematopoietic progenitor cells. Biotechnology and Bioengineering. 43: 734-9. PMID 18615796 DOI: 10.1002/Bit.260430807 |
0.609 |
|
| 1994 |
Lee GM, Kim SJ, Palsson BO. Enhanced specific antibody productivity of calcium alginate-entrapped hybridoma is cell line-specific. Cytotechnology. 16: 1-15. PMID 7765785 DOI: 10.1007/Bf00761774 |
0.569 |
|
| 1994 |
Lee GM, Palsson BO. Monoclonal antibody production using free-suspended and entrapped hybridoma cells. Biotechnology & Genetic Engineering Reviews. 12: 509-33. PMID 7727036 DOI: 10.1080/02648725.1994.10647920 |
0.569 |
|
| 1994 |
Lee S, Rhee S, Lee G. Biodegradation of pyridine by freely suspended and immobilized Pimelobacter sp. Applied Microbiology and Biotechnology. 41: 652-657. DOI: 10.1007/Bf00167280 |
0.471 |
|
| 1994 |
Shin JH, Lee GM, Kim JH. Comparison of cell disruption methods for determining β-galactosidase activity expressed in animal cells Biotechnology Techniques. 8: 425-430. DOI: 10.1007/Bf00154315 |
0.446 |
|
| 1993 |
Lee GM, Palsson BO. Stability of antibody productivity is improved when hybridoma cells are entrapped in calcium alginate beads. Biotechnology and Bioengineering. 42: 1131-5. PMID 18613244 DOI: 10.1002/Bit.260420917 |
0.618 |
|
| 1993 |
Lee GM, Chuck AS, Palsson BO. Cell Culture conditions determine the enhancement of specific monoclonal antibody productivity of calcium alginate-entrapped S3H5/gamma2bA2 hybridoma cells. Biotechnology and Bioengineering. 41: 330-40. PMID 18609557 DOI: 10.1002/Bit.260410307 |
0.764 |
|
| 1993 |
Palsson BO, Paek SH, Schwartz RM, Palsson M, Lee GM, Silver S, Emerson SG. Expansion of human bone marrow progenitor cells in a high cell density continuous perfusion system. Bio/Technology (Nature Publishing Company). 11: 368-72. PMID 7763438 DOI: 10.1038/Nbt0393-368 |
0.683 |
|
| 1993 |
Lee GM, Chuck AS, Palsson BO. Effect of fixation temperature on flow cytometric measurement of intracellular antibody content of hybridomas during batch culture Biotechnology Techniques. 7: 271-276. DOI: 10.1007/Bf00150897 |
0.732 |
|
| 1992 |
Lee GM, Kaminski MS, Palsson BO. Observations consistent with autocrine stimulation of hybridoma cell growth and implications for large-scale antibody production Biotechnology Letters. 14: 257-262. DOI: 10.1007/Bf01022320 |
0.615 |
|
| 1992 |
Lee GM, Han BK, Kim JH, Palsson BO. Effect of calcium chloride treatment on hybridoma cell viability and growth Biotechnology Letters. 14: 891-896. DOI: 10.1007/Bf01020624 |
0.476 |
|
| 1991 |
Lee GM, Varma A, Palsson BO. Production of monoclonal antibody using free-suspended and immobilized hybridoma cells: Effect of serum. Biotechnology and Bioengineering. 38: 821-30. PMID 18600839 DOI: 10.1002/Bit.260380804 |
0.727 |
|
| 1991 |
Lee GM, Varma A, Palsson BO. Application of population balance model to the loss of hybridoma antibody productivity. Biotechnology Progress. 7: 72-5. PMID 1366981 DOI: 10.1021/Bp00007A013 |
0.625 |
|
| 1991 |
Lee GM, Gray JJ, Palsson B. Effect of trisodium citrate treatment on hybridoma cell viability Biotechnology Techniques. 5: 295-298. DOI: 10.1007/Bf02438666 |
0.579 |
|
| 1990 |
Lee GM, Palsson BO. Immobilization can improve the stability of hybridoma antibody productivity in serum-free media. Biotechnology and Bioengineering. 36: 1049-55. PMID 18595043 DOI: 10.1002/Bit.260361010 |
0.57 |
|
| 1990 |
Lee GM, Palsson BO. Simplified method of making alginate-polylysine microcapsules for hybridoma cell culture using RPMI 1640 medium Biotechnology Techniques. 4: 341-344. DOI: 10.1007/Bf00157433 |
0.579 |
|
| 1989 |
Lee GM, Huard TK, Palsson BO. Effect of serum concentration on hybridoma cell growth and monoclonal antibody production at various initial cell densities. Hybridoma. 8: 369-75. PMID 2744789 DOI: 10.1089/Hyb.1989.8.369 |
0.622 |
|
| 1989 |
Lee GM, Savinell JM, Palsson BO. Serum can act as a shear protecting agent in agitated hybridoma cell cultures. Hybridoma. 8: 639-45. PMID 2693339 DOI: 10.1089/Hyb.1989.8.639 |
0.78 |
|
| 1989 |
Savinell JM, Lee GM, Palsson BO. On the orders of magnitude of epigenic dynamics and monoclonal antibody production Bioprocess Engineering. 4: 231-234. DOI: 10.1007/Bf00369177 |
0.783 |
|
| 1988 |
Lee GM, Huard TK, Kaminski MS, Palsson BO. Effect of mechanical agitation on hybridoma cell growth Biotechnology Letters. 10: 625-628. DOI: 10.1007/Bf01024713 |
0.527 |
|
| 1986 |
Lee GM, Song KB, Rhee SK, Han MH. Plasmid maintenance and growth of recombinant Saccharomyces cerevisiae producing hepatitis B virus surface antigen Biotechnology Letters. 8: 385-390. DOI: 10.1007/Bf01026737 |
0.335 |
|
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