| Year |
Citation |
Score |
| 2022 |
Karim RM, Yang L, Chen L, Bikowitz MJ, Lu J, Grassie D, Shultz ZP, Lopchuk JM, Chen J, Schönbrunn E. Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain. Journal of Medicinal Chemistry. PMID 35191694 DOI: 10.1021/acs.jmedchem.1c01999 |
0.305 |
|
| 2021 |
Lu J, Chen L, Song Z, Das M, Chen J. Hypothermia effectively treats tumors with temperature-sensitive p53 mutations. Cancer Research. PMID 33687951 DOI: 10.1158/0008-5472.CAN-21-0033 |
0.324 |
|
| 2020 |
Li Q, Karim RM, Cheng M, Das M, Chen L, Zhang C, Lawrence HR, Daughdrill GW, Schonbrunn E, Ji H, Chen J. Inhibition of p53 DNA binding by a small molecule protects mice from radiation toxicity. Oncogene. PMID 32555331 DOI: 10.1038/S41388-020-1344-Y |
0.357 |
|
| 2020 |
Huang Q, Chen L, Schonbrunn E, Chen J. MDMX inhibits casein kinase 1α activity and stimulates Wnt signaling. The Embo Journal. e104410. PMID 32511789 DOI: 10.15252/Embj.2020104410 |
0.336 |
|
| 2020 |
Sang P, Shi Y, Lu J, Chen L, Yang L, Borcherds W, Abdulkadir S, Li Q, Daughdrill GW, Chen J, Cai J. α-Helix-Mimicking Sulfono-γ-AApeptide Inhibitors for p53-MDM2/MDMX Protein-Protein Interactions. Journal of Medicinal Chemistry. PMID 31971801 DOI: 10.1021/Acs.Jmedchem.9B00993 |
0.428 |
|
| 2019 |
He F, Borcherds W, Song T, Wei X, Das M, Chen L, Daughdrill GW, Chen J. Interaction between p53 N terminus and core domain regulates specific and nonspecific DNA binding. Proceedings of the National Academy of Sciences of the United States of America. PMID 30988205 DOI: 10.1073/Pnas.1903077116 |
0.447 |
|
| 2018 |
Yang L, Song T, Cheng Q, Chen L, Chen J. Mutant p53 sequestration of MDM2 acidic domain inhibits E3 ligase activity. Molecular and Cellular Biology. PMID 30455251 DOI: 10.1128/Mcb.00375-18 |
0.457 |
|
| 2018 |
Huang Q, Chen L, Yang L, Xie X, Gan L, Cleveland JL, Chen J. MDMX acidic domain inhibits p53 DNA binding in vivo and regulates tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 29581299 DOI: 10.1073/Pnas.1719090115 |
0.501 |
|
| 2017 |
Yang L, Fang J, Chen J. Tumor cell senescence response produces aggressive variants. Cell Death Discovery. 3: 17049. PMID 28845296 DOI: 10.1038/Cddiscovery.2017.49 |
0.357 |
|
| 2017 |
Borcherds W, Becker A, Chen L, Chen J, Chemes LB, Daughdrill GW. Optimal Affinity Enhancement by a Conserved Flexible Linker Controls p53 Mimicry in MdmX. Biophysical Journal. PMID 28487147 DOI: 10.1016/J.Bpj.2017.04.017 |
0.401 |
|
| 2016 |
Chen J. Intra molecular interactions in the regulation of p53 pathway. Translational Cancer Research. 5: 639-649. PMID 30613472 DOI: 10.21037/tcr.2016.09.23 |
0.378 |
|
| 2016 |
Elf S, Lin R, Xia S, Pan Y, Shan C, Wu S, Lonial S, Gaddh M, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Boggon TJ, Fan J, Chen J. Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin. Oncogene. PMID 27270429 DOI: 10.1038/onc.2016.196 |
0.357 |
|
| 2016 |
Chen Y, Li C, Pan Y, Han S, Feng B, Gao Y, Chen J, Zhang K, Wang R, Chen L. The Emerging Role and Promise of Long Noncoding RNAs in Lung Cancer Treatment. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 38: 2194-2206. PMID 27183839 DOI: 10.1159/000445575 |
0.32 |
|
| 2016 |
Wei X, Wu S, Song T, Chen L, Gao M, Borcherds W, Daughdrill GW, Chen J. Secondary interaction between MDMX and p53 core domain inhibits p53 DNA binding. Proceedings of the National Academy of Sciences of the United States of America. PMID 27114532 DOI: 10.1073/Pnas.1603838113 |
0.488 |
|
| 2016 |
Chohan TA, Chen JJ, Qian HY, Pan YL, Chen JZ. Molecular modeling studies to characterize N-phenylpyrimidin-2-amine selectivity for CDK2 and CDK4 through 3D-QSAR and molecular dynamics simulations. Molecular Biosystems. PMID 26883408 DOI: 10.1039/c5mb00860c |
0.349 |
|
| 2016 |
Cekan P, Hasegawa K, Pan Y, Tubman E, Odde D, Chen JQ, Herrmann MA, Kumar S, Kalab P. RCC1-dependent activation of Ran accelerates cell cycle and DNA repair, inhibiting DNA damage-induced cell senescence. Molecular Biology of the Cell. PMID 26864624 DOI: 10.1091/Mbc.E16-01-0025 |
0.393 |
|
| 2015 |
Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Aparin A, Arkhipkin D, Aschenauer EC, Averichev GS, Banerjee A, Bellwied R, Bhasin A, Bhati AK, ... ... Chen JH, et al. Observation of Transverse Spin-Dependent Azimuthal Correlations of Charged Pion Pairs in p^{↑}+p at sqrt[s]=200 GeV. Physical Review Letters. 115: 242501. PMID 26705627 DOI: 10.1103/Physrevlett.115.242501 |
0.385 |
|
| 2015 |
Chen Y, Gao Y, Zhang K, Li C, Pan Y, Chen J, Wang R, Chen L. MicroRNAs as Regulators of Cisplatin Resistance in Lung Cancer. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 37: 1869-1880. PMID 26584286 DOI: 10.1159/000438548 |
0.303 |
|
| 2015 |
Chohan TA, Qian HY, Pan YL, Chen JZ. Molecular simulation studies on the binding selectivity of 2-anilino-4-(thiazol-5-yl)-pyrimidines in complexes with CDK2 and CDK7. Molecular Biosystems. PMID 26565382 DOI: 10.1039/c5mb00630a |
0.353 |
|
| 2015 |
Wu Q, Zhong ZM, Zhu SY, Liao CR, Pan Y, Zeng JH, Zheng S, Ding RT, Lin QS, Ye Q, Ye WB, Li W, Chen JT. Advanced oxidation protein products induce chondrocyte apoptosis via receptor for advanced glycation end products-mediated, redox-dependent intrinsic apoptosis pathway. Apoptosis : An International Journal On Programmed Cell Death. PMID 26520447 DOI: 10.1007/s10495-015-1191-4 |
0.322 |
|
| 2015 |
Yang L, Song T, Chen L, Soliman H, Chen J. Nucleolar repression facilitates initiation and maintenance of senescence. Cell Cycle (Georgetown, Tex.). 0. PMID 26505814 DOI: 10.1080/15384101.2015.1100777 |
0.417 |
|
| 2015 |
Pan Y, He B, Chen J, Sun H, Deng Q, Wang F, Ying H, Liu X, Lin K, Peng H, Xie H, Wang S. Gene therapy for colorectal cancer by adenovirus-mediated siRNA targeting CD147 based on loss of the IGF2 imprinting system. International Journal of Oncology. PMID 26397886 DOI: 10.3892/ijo.2015.3181 |
0.33 |
|
| 2015 |
Zhang Y, Seeburg DP, Pulli B, Wojtkiewicz GR, Bure L, Atkinson W, Schob S, Iwamoto Y, Ali M, Zhang W, Rodriguez E, Milewski A, Keliher EJ, Wang C, Pan Y, ... ... Chen JW, et al. Myeloperoxidase Nuclear Imaging for Epileptogenesis. Radiology. 141922. PMID 26397127 DOI: 10.1148/Radiol.2015141922 |
0.329 |
|
| 2015 |
Chen J, Deng Q, Pan Y, He B, Ying H, Sun H, Liu X, Wang S. Prognostic value of neutrophil-to-lymphocyte ratio in breast cancer. Febs Open Bio. 5: 502-7. PMID 26137435 DOI: 10.1016/j.fob.2015.05.003 |
0.328 |
|
| 2015 |
Ying HQ, Chen J, He BS, Pan YQ, Wang F, Deng QW, Sun HL, Liu X, Wang SK. The effect of BIM deletion polymorphism on intrinsic resistance and clinical outcome of cancer patient with kinase inhibitor therapy. Scientific Reports. 5: 11348. PMID 26076815 DOI: 10.1038/srep11348 |
0.308 |
|
| 2015 |
Chen A, Huang X, Xue Z, Cao D, Huang K, Chen J, Pan Y, Gao Y. The Role of p21 in Apoptosis, Proliferation, Cell Cycle Arrest, and Antioxidant Activity in UVB-Irradiated Human HaCaT Keratinocytes. Medical Science Monitor Basic Research. 21: 86-95. PMID 25925725 DOI: 10.12659/MSMBR.893608 |
0.504 |
|
| 2015 |
Sun L, Kokura K, Izumi V, Koomen JM, Seto E, Chen J, Fang J. MPP8 and SIRT1 crosstalk in E-cadherin gene silencing and epithelial-mesenchymal transition. Embo Reports. 16: 689-99. PMID 25870236 DOI: 10.15252/Embr.201439792 |
0.343 |
|
| 2015 |
Chen L, Borcherds W, Wu S, Becker A, Schonbrunn E, Daughdrill GW, Chen J. Autoinhibition of MDMX by intramolecular p53 mimicry. Proceedings of the National Academy of Sciences of the United States of America. 112: 4624-9. PMID 25825738 DOI: 10.1073/Pnas.1420833112 |
0.394 |
|
| 2015 |
Peng L, Yuan Z, Li Y, Ling H, Izumi V, Fang B, Fukasawa K, Koomen J, Chen J, Seto E. Ubiquitinated sirtuin 1 (SIRT1) function is modulated during DNA damage-induced cell death and survival. The Journal of Biological Chemistry. 290: 8904-12. PMID 25670865 DOI: 10.1074/Jbc.M114.612796 |
0.366 |
|
| 2014 |
Zhang M, Xiang S, Joo HY, Wang L, Williams KA, Liu W, Hu C, Tong D, Haakenson J, Wang C, Zhang S, Pavlovicz RE, Jones A, Schmidt KH, Tang J, ... ... Chen J, et al. HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSα. Molecular Cell. 55: 31-46. PMID 24882211 DOI: 10.1016/J.Molcel.2014.04.028 |
0.346 |
|
| 2014 |
Cheng Q, Song T, Chen L, Chen J. Autoactivation of the MDM2 E3 ligase by intramolecular interaction. Molecular and Cellular Biology. 34: 2800-10. PMID 24842904 DOI: 10.1128/Mcb.00246-14 |
0.426 |
|
| 2014 |
Schneeberger VE, Luetteke N, Ren Y, Berns H, Chen L, Foroutan P, Martinez GV, Haura EB, Chen J, Coppola D, Wu J. SHP2E76K mutant promotes lung tumorigenesis in transgenic mice. Carcinogenesis. 35: 1717-25. PMID 24480804 DOI: 10.1093/Carcin/Bgu025 |
0.319 |
|
| 2013 |
Zheng H, Yang L, Peng L, Izumi V, Koomen J, Seto E, Chen J. hMOF acetylation of DBC1/CCAR2 prevents binding and inhibition of SirT1. Molecular and Cellular Biology. 33: 4960-70. PMID 24126058 DOI: 10.1128/Mcb.00874-13 |
0.412 |
|
| 2013 |
Yang L, Song T, Chen L, Kabra N, Zheng H, Koomen J, Seto E, Chen J. Regulation of SirT1-nucleomethylin binding by rRNA coordinates ribosome biogenesis with nutrient availability. Molecular and Cellular Biology. 33: 3835-48. PMID 23897426 DOI: 10.1128/Mcb.00476-13 |
0.665 |
|
| 2013 |
Song T, Yang L, Kabra N, Chen L, Koomen J, Haura EB, Chen J. The NAD+ synthesis enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT1) regulates ribosomal RNA transcription. The Journal of Biological Chemistry. 288: 20908-17. PMID 23737528 DOI: 10.1074/Jbc.M113.470302 |
0.693 |
|
| 2013 |
Tang J, Agrawal T, Cheng Q, Qu L, Brewer MD, Chen J, Yang X. Phosphorylation of Daxx by ATM contributes to DNA damage-induced p53 activation. Plos One. 8: e55813. PMID 23405218 DOI: 10.1371/Journal.Pone.0055813 |
0.356 |
|
| 2013 |
Hodul PJ, Dong Y, Husain K, Pimiento JM, Chen J, Zhang A, Francois R, Pledger WJ, Coppola D, Sebti SM, Chen DT, Malafa MP. Vitamin E δ-tocotrienol induces p27(Kip1)-dependent cell-cycle arrest in pancreatic cancer cells via an E2F-1-dependent mechanism. Plos One. 8: e52526. PMID 23393547 DOI: 10.1371/Journal.Pone.0052526 |
0.386 |
|
| 2012 |
Wu S, Chen L, Becker A, Schonbrunn E, Chen J. Casein kinase 1α regulates an MDMX intramolecular interaction to stimulate p53 binding. Molecular and Cellular Biology. 32: 4821-32. PMID 23028042 DOI: 10.1128/Mcb.00851-12 |
0.468 |
|
| 2012 |
Peng L, Ling H, Yuan Z, Fang B, Bloom G, Fukasawa K, Koomen J, Chen J, Lane WS, Seto E. SIRT1 negatively regulates the activities, functions, and protein levels of hMOF and TIP60. Molecular and Cellular Biology. 32: 2823-36. PMID 22586264 DOI: 10.1128/Mcb.00496-12 |
0.388 |
|
| 2012 |
Wong CC, Zhang H, Gilkes DM, Chen J, Wei H, Chaturvedi P, Hubbi ME, Semenza GL. Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis. Journal of Molecular Medicine (Berlin, Germany). 90: 803-15. PMID 22231744 DOI: 10.1007/S00109-011-0855-Y |
0.742 |
|
| 2012 |
Li X, Gilkes D, Li B, Cheng Q, Pernazza D, Lawrence H, Lawrence N, Chen J. Abnormal MDMX degradation in tumor cells due to ARF deficiency. Oncogene. 31: 3721-32. PMID 22120712 DOI: 10.1038/Onc.2011.534 |
0.788 |
|
| 2012 |
Zhang H, Wong CC, Wei H, Gilkes DM, Korangath P, Chaturvedi P, Schito L, Chen J, Krishnamachary B, Winnard PT, Raman V, Zhen L, Mitzner WA, Sukumar S, Semenza GL. HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs. Oncogene. 31: 1757-70. PMID 21860410 DOI: 10.1038/Onc.2011.365 |
0.753 |
|
| 2011 |
Muppidi A, Li X, Chen J, Lin Q. Conjugation of spermine enhances cellular uptake of the stapled peptide-based inhibitors of p53-Mdm2 interaction. Bioorganic & Medicinal Chemistry Letters. 21: 7412-5. PMID 22047690 DOI: 10.1016/J.Bmcl.2011.10.009 |
0.312 |
|
| 2011 |
Cheng Q, Cross B, Li B, Chen L, Li Z, Chen J. Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage. Molecular and Cellular Biology. 31: 4951-63. PMID 21986495 DOI: 10.1128/Mcb.05553-11 |
0.779 |
|
| 2011 |
Peng L, Yuan Z, Ling H, Fukasawa K, Robertson K, Olashaw N, Koomen J, Chen J, Lane WS, Seto E. SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities. Molecular and Cellular Biology. 31: 4720-34. PMID 21947282 DOI: 10.1128/Mcb.06147-11 |
0.389 |
|
| 2011 |
Wong CC, Gilkes DM, Zhang H, Chen J, Wei H, Chaturvedi P, Fraley SI, Wong CM, Khoo US, Ng IO, Wirtz D, Semenza GL. Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. Proceedings of the National Academy of Sciences of the United States of America. 108: 16369-74. PMID 21911388 DOI: 10.1073/Pnas.1113483108 |
0.745 |
|
| 2011 |
Cross B, Chen L, Cheng Q, Li B, Yuan ZM, Chen J. Inhibition of p53 DNA binding function by the MDM2 protein acidic domain. The Journal of Biological Chemistry. 286: 16018-29. PMID 21454483 DOI: 10.1074/Jbc.M111.228981 |
0.801 |
|
| 2011 |
Madden MM, Muppidi A, Li Z, Li X, Chen J, Lin Q. Synthesis of cell-permeable stapled peptide dual inhibitors of the p53-Mdm2/Mdmx interactions via photoinduced cycloaddition. Bioorganic & Medicinal Chemistry Letters. 21: 1472-5. PMID 21277201 DOI: 10.1016/J.Bmcl.2011.01.004 |
0.318 |
|
| 2011 |
Shen J, Zhang S, Li Y, Zhang W, Chen J, Zhang M, Wang T, Jiang L, Zou X, Wong J, Li X, Cui Y, Wang C. p14(ARF) inhibits the functions of adenovirus E1A oncoprotein. The Biochemical Journal. 434: 275-85. PMID 21133853 DOI: 10.1042/Bj20101163 |
0.478 |
|
| 2011 |
Cross BL, Cheng Q, Li B, Yuan Z, Chen J. Abstract 3090: Inhibition of p53 DNA binding function by the MDM2 acidic domain Cancer Research. 71: 3090-3090. DOI: 10.1158/1538-7445.Am2011-3090 |
0.496 |
|
| 2010 |
Chen L, Li Z, Zwolinska AK, Smith MA, Cross B, Koomen J, Yuan ZM, Jenuwein T, Marine JC, Wright KL, Chen J. MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output. The Embo Journal. 29: 2538-52. PMID 20588255 DOI: 10.1038/Emboj.2010.140 |
0.797 |
|
| 2010 |
Li C, Pazgier M, Li J, Li C, Liu M, Zou G, Li Z, Chen J, Tarasov SG, Lu WY, Lu W. Limitations of peptide retro-inverso isomerization in molecular mimicry. The Journal of Biological Chemistry. 285: 19572-81. PMID 20382735 DOI: 10.1074/Jbc.M110.116814 |
0.319 |
|
| 2010 |
Li B, Cheng Q, Li Z, Chen J. p53 inactivation by MDM2 and MDMX negative feedback loops in testicular germ cell tumors. Cell Cycle (Georgetown, Tex.). 9: 1411-20. PMID 20372076 DOI: 10.4161/Cc.9.7.11255 |
0.507 |
|
| 2010 |
Yuan Z, Villagra A, Peng L, Coppola D, Glozak M, Sotomayor EM, Chen J, Lane WS, Seto E. The ATDC (TRIM29) protein binds p53 and antagonizes p53-mediated functions. Molecular and Cellular Biology. 30: 3004-15. PMID 20368352 DOI: 10.1128/Mcb.01023-09 |
0.491 |
|
| 2010 |
Cheng Q, Chen J. Mechanism of p53 stabilization by ATM after DNA damage. Cell Cycle (Georgetown, Tex.). 9: 472-8. PMID 20081365 |
0.413 |
|
| 2010 |
Zhang Y, Dong H, Li Z, Xiang S, Zhu Y, Zhang M, Liu J, Bai W, Nicosia SV, Chen J, Zhao RJ, Zhang X. Bing De Ling, a Chinese herbal formula, inhibits cancer cells growth via p53. Frontiers in Bioscience (Elite Edition). 2: 221-30. PMID 20036872 DOI: 10.2741/E84 |
0.494 |
|
| 2010 |
Phan J, Li Z, Kasprzak A, Li B, Sebti S, Guida W, Schönbrunn E, Chen J. Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX. The Journal of Biological Chemistry. 285: 2174-83. PMID 19910468 DOI: 10.1074/Jbc.M109.073056 |
0.426 |
|
| 2009 |
Cheng Q, Chen L, Li Z, Lane WS, Chen J. ATM activates p53 by regulating MDM2 oligomerization and E3 processivity. The Embo Journal. 28: 3857-67. PMID 19816404 DOI: 10.1038/Emboj.2009.294 |
0.46 |
|
| 2009 |
Lawrence HR, Li Z, Yip ML, Sung SS, Lawrence NJ, McLaughlin ML, McManus GJ, Zaworotko MJ, Sebti SM, Chen J, Guida WC. Identification of a disruptor of the MDM2-p53 protein-protein interaction facilitated by high-throughput in silico docking. Bioorganic & Medicinal Chemistry Letters. 19: 3756-9. PMID 19457663 DOI: 10.1016/J.Bmcl.2009.04.124 |
0.321 |
|
| 2009 |
Kabra N, Li Z, Chen L, Li B, Zhang X, Wang C, Yeatman T, Coppola D, Chen J. SirT1 is an inhibitor of proliferation and tumor formation in colon cancer. The Journal of Biological Chemistry. 284: 18210-7. PMID 19433578 DOI: 10.1074/Jbc.M109.000034 |
0.674 |
|
| 2009 |
Fu W, Ma Q, Chen L, Li P, Zhang M, Ramamoorthy S, Nawaz Z, Shimojima T, Wang H, Yang Y, Shen Z, Zhang Y, Zhang X, Nicosia SV, Zhang Y, ... ... Chen J, et al. MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation. The Journal of Biological Chemistry. 284: 13987-4000. PMID 19321440 DOI: 10.1074/Jbc.M901758200 |
0.467 |
|
| 2009 |
Yamaguchi H, Woods NT, Piluso LG, Lee HH, Chen J, Bhalla KN, Monteiro A, Liu X, Hung MC, Wang HG. p53 acetylation is crucial for its transcription-independent proapoptotic functions. The Journal of Biological Chemistry. 284: 11171-83. PMID 19265193 DOI: 10.1074/Jbc.M809268200 |
0.482 |
|
| 2009 |
Li Z, Chen L, Kabra N, Wang C, Fang J, Chen J. Inhibition of SUV39H1 methyltransferase activity by DBC1. The Journal of Biological Chemistry. 284: 10361-6. PMID 19218236 DOI: 10.1074/Jbc.M900956200 |
0.678 |
|
| 2009 |
Zhang Y, Zhang M, Dong H, Yong S, Li X, Olashaw N, Kruk PA, Cheng JQ, Bai W, Chen J, Nicosia SV, Zhang X. Deacetylation of cortactin by SIRT1 promotes cell migration. Oncogene. 28: 445-60. PMID 18850005 DOI: 10.1038/Onc.2008.388 |
0.409 |
|
| 2008 |
Yang W, Dicker DT, Chen J, El-Deiry WS. CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2. Cell Cycle (Georgetown, Tex.). 7: 670-82. PMID 18382127 DOI: 10.4161/Cc.7.5.5701 |
0.361 |
|
| 2008 |
Gilkes DM, Pan Y, Coppola D, Yeatman T, Reuther GW, Chen J. Regulation of MDMX expression by mitogenic signaling. Molecular and Cellular Biology. 28: 1999-2010. PMID 18172009 DOI: 10.1128/Mcb.01633-07 |
0.791 |
|
| 2007 |
Yang Y, Fu W, Chen J, Olashaw N, Zhang X, Nicosia SV, Bhalla K, Bai W. SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress. Nature Cell Biology. 9: 1253-62. PMID 17934453 DOI: 10.1038/Ncb1645 |
0.359 |
|
| 2007 |
Hu B, Gilkes DM, Chen J. Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX. Cancer Research. 67: 8810-7. PMID 17875722 DOI: 10.1158/0008-5472.Can-07-1140 |
0.795 |
|
| 2007 |
Wang C, Rauscher FJ, Cress WD, Chen J. Regulation of E2F1 function by the nuclear corepressor KAP1. The Journal of Biological Chemistry. 282: 29902-9. PMID 17704056 DOI: 10.1074/Jbc.M704757200 |
0.387 |
|
| 2007 |
Gilkes DM, Chen J. Distinct roles of MDMX in the regulation of p53 response to ribosomal stress. Cell Cycle (Georgetown, Tex.). 6: 151-5. PMID 17327702 DOI: 10.4161/Cc.6.2.3719 |
0.779 |
|
| 2006 |
Gilkes DM, Chen L, Chen J. MDMX regulation of p53 response to ribosomal stress. The Embo Journal. 25: 5614-25. PMID 17110929 DOI: 10.1038/Sj.Emboj.7601424 |
0.786 |
|
| 2006 |
Hu B, Gilkes DM, Farooqi B, Sebti SM, Chen J. MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin. The Journal of Biological Chemistry. 281: 33030-5. PMID 16905541 DOI: 10.1074/Jbc.C600147200 |
0.793 |
|
| 2006 |
Wang C, Chen L, Hou X, Li Z, Kabra N, Ma Y, Nemoto S, Finkel T, Gu W, Cress WD, Chen J. Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nature Cell Biology. 8: 1025-31. PMID 16892051 DOI: 10.1038/Ncb1468 |
0.698 |
|
| 2006 |
LeBron C, Chen L, Gilkes DM, Chen J. Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3. The Embo Journal. 25: 1196-206. PMID 16511560 DOI: 10.1038/Sj.Emboj.7601032 |
0.793 |
|
| 2005 |
Chen L, Gilkes DM, Pan Y, Lane WS, Chen J. ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage. The Embo Journal. 24: 3411-22. PMID 16163388 DOI: 10.1038/Sj.Emboj.7600812 |
0.784 |
|
| 2005 |
Wang C, Ivanov A, Chen L, Fredericks WJ, Seto E, Rauscher FJ, Chen J. MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation. The Embo Journal. 24: 3279-90. PMID 16107876 DOI: 10.1038/Sj.Emboj.7600791 |
0.521 |
|
| 2005 |
Chen L, Li C, Pan Y, Chen J. Regulation of p53-MDMX interaction by casein kinase 1 alpha. Molecular and Cellular Biology. 25: 6509-20. PMID 16024788 DOI: 10.1128/Mcb.25.15.6509-6520.2005 |
0.592 |
|
| 2005 |
Chen L, Yin H, Farooqi B, Sebti S, Hamilton AD, Chen J. p53 alpha-Helix mimetics antagonize p53/MDM2 interaction and activate p53. Molecular Cancer Therapeutics. 4: 1019-25. PMID 15956260 DOI: 10.1158/1535-7163.Mct-04-0342 |
0.355 |
|
| 2005 |
Pan Y, Chen J. Modification of MDMX by sumoylation. Biochemical and Biophysical Research Communications. 332: 702-9. PMID 15907800 DOI: 10.1016/J.Bbrc.2005.05.012 |
0.527 |
|
| 2005 |
Wang C, Hou X, Mohapatra S, Ma Y, Cress WD, Pledger WJ, Chen J. Activation of p27Kip1 Expression by E2F1. A negative feedback mechanism. The Journal of Biological Chemistry. 280: 12339-43. PMID 15713665 DOI: 10.1074/Jbc.C400536200 |
0.493 |
|
| 2004 |
Liu Q, Kaneko S, Yang L, Feldman RI, Nicosia SV, Chen J, Cheng JQ. Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215. The Journal of Biological Chemistry. 279: 52175-82. PMID 15469940 DOI: 10.1074/Jbc.M406802200 |
0.485 |
|
| 2004 |
Yamaguchi H, Chen J, Bhalla K, Wang HG. Regulation of Bax activation and apoptotic response to microtubule-damaging agents by p53 transcription-dependent and -independent pathways. The Journal of Biological Chemistry. 279: 39431-7. PMID 15262986 DOI: 10.1074/Jbc.M401530200 |
0.479 |
|
| 2004 |
Wang JW, Gamsby JJ, Highfill SL, Mora LB, Bloom GC, Yeatman TJ, Pan TC, Ramne AL, Chodosh LA, Cress WD, Chen J, Kerr WG. Deregulated expression of LRBA facilitates cancer cell growth. Oncogene. 23: 4089-97. PMID 15064745 DOI: 10.1038/Sj.Onc.1207567 |
0.398 |
|
| 2003 |
Chen L, Chen J. MDM2-ARF complex regulates p53 sumoylation. Oncogene. 22: 5348-57. PMID 12917636 DOI: 10.1038/sj.onc.1206851 |
0.382 |
|
| 2003 |
Peng Y, Li C, Chen L, Sebti S, Chen J. Rescue of mutant p53 transcription function by ellipticine. Oncogene. 22: 4478-87. PMID 12881704 DOI: 10.1038/Sj.Onc.1206777 |
0.387 |
|
| 2003 |
Pan Y, Chen J. MDM2 promotes ubiquitination and degradation of MDMX. Molecular and Cellular Biology. 23: 5113-21. PMID 12860999 DOI: 10.1128/Mcb.23.15.5113-5121.2003 |
0.606 |
|
| 2003 |
Wang C, Chen J. Phosphorylation and hsp90 binding mediate heat shock stabilization of p53. The Journal of Biological Chemistry. 278: 2066-71. PMID 12427754 DOI: 10.1074/Jbc.M206697200 |
0.399 |
|
| 2002 |
Li C, Chen L, Chen J. DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms. Molecular and Cellular Biology. 22: 7562-71. PMID 12370303 DOI: 10.1128/Mcb.22.21.7562-7571.2002 |
0.503 |
|
| 2002 |
Lu W, Lin J, Chen J. Expression of p14ARF overcomes tumor resistance to p53. Cancer Research. 62: 1305-10. PMID 11888896 |
0.311 |
|
| 2000 |
Witherow DS, Wang Q, Levay K, Cabrera JL, Chen J, Willars GB, Slepak VZ. Complexes of the G protein subunit gbeta 5 with the regulators of G protein signaling RGS7 and RGS9. Characterization in native tissues and in transfected cells. The Journal of Biological Chemistry. 275: 24872-80. PMID 10840031 DOI: 10.1074/Jbc.M001535200 |
0.316 |
|
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