| Year |
Citation |
Score |
| 2023 |
Hoffman A, Stampolaki M, Tzitzoglaki C, Schmerer P, Ma C, Döring K, Turcu A, Wang J, Vazquez S, Schmidtke M, Kolokouris A, Stylianakis I, Movellan KT, Andreas L, Becker S. Adamantyl Amines Activity Study Against Mutant Influenza A M2 Channels Identified a Polycyclic Cage Amine Triple blocker Explored with MD simulations and Solid state NMR. Chemmedchem. e202300182. PMID 37377066 DOI: 10.1002/cmdc.202300182 |
0.374 |
|
| 2022 |
Tan H, Ma C, Wang J. Invalidation of dieckol and 1,2,3,4,6-pentagalloylglucose (PGG) as SARS-CoV-2 main protease inhibitors and the discovery of PGG as a papain-like protease inhibitor. Medicinal Chemistry Research : An International Journal For Rapid Communications On Design and Mechanisms of Action of Biologically Active Agents. 1-7. PMID 35578732 DOI: 10.1007/s00044-022-02903-0 |
0.329 |
|
| 2022 |
Tan H, Ma C, Wang J. Invalidation of dieckol and 1,2,3,4,6-pentagalloylglucose (PGG) as SARS-CoV-2 main protease inhibitors and the discovery of PGG as a papain-like protease inhibitor. Research Square. PMID 35378761 DOI: 10.21203/rs.3.rs-1490282/v1 |
0.33 |
|
| 2021 |
Ma C, Tan H, Choza J, Wang Y, Wang J. Validation and invalidation of SARS-CoV-2 main protease inhibitors using the Flip-GFP and Protease-Glo luciferase assays. Acta Pharmaceutica Sinica. B. PMID 34745850 DOI: 10.1016/j.apsb.2021.10.026 |
0.3 |
|
| 2021 |
Cáceres CJ, Hu Y, Cárdenas-García S, Tan H, Wu X, Carnaccini S, Gay LC, Geiger G, Ma C, Zhang QY, Rajao D, Perez DR, Wang J. Rational design of a deuterium-containing M2-S31N channel blocker UAWJ280 with antiviral efficacy against both oseltamivir sensitive and -resistant influenza A viruses. Emerging Microbes & Infections. 1-38. PMID 34427541 DOI: 10.1080/22221751.2021.1972769 |
0.375 |
|
| 2021 |
Xia Z, Sacco M, Hu Y, Ma C, Meng X, Zhang F, Szeto T, Xiang Y, Chen Y, Wang J. Rational Design of Hybrid SARS-CoV-2 Main Protease Inhibitors Guided by the Superimposed Cocrystal Structures with the Peptidomimetic Inhibitors GC-376, Telaprevir, and Boceprevir. Acs Pharmacology & Translational Science. 4: 1408-1421. PMID 34414360 DOI: 10.1021/acsptsci.1c00099 |
0.311 |
|
| 2021 |
Thomaston JL, Samways ML, Konstantinidi A, Ma C, Hu Y, Bruce Macdonald HE, Wang J, Essex JW, DeGrado WF, Kolocouris A. Rimantadine Binds to and Inhibits the Influenza A M2 Proton Channel without Enantiomeric Specificity. Biochemistry. PMID 34342217 DOI: 10.1021/acs.biochem.1c00437 |
0.353 |
|
| 2021 |
Kitamura N, Sacco MD, Ma C, Hu Y, Townsend JA, Meng X, Zhang F, Zhang X, Ba M, Szeto T, Kukuljac A, Marty MT, Schultz D, Cherry S, Xiang Y, et al. Expedited Approach toward the Rational Design of Noncovalent SARS-CoV-2 Main Protease Inhibitors. Journal of Medicinal Chemistry. PMID 33891389 DOI: 10.1021/acs.jmedchem.1c00509 |
0.323 |
|
| 2020 |
Ma C, Hu Y, Townsend JA, Lagarias PI, Marty MT, Kolocouris A, Wang J. Ebselen, Disulfiram, Carmofur, PX-12, Tideglusib, and Shikonin Are Nonspecific Promiscuous SARS-CoV-2 Main Protease Inhibitors. Acs Pharmacology & Translational Science. 3: 1265-1277. PMID 33330841 DOI: 10.1021/acsptsci.0c00130 |
0.323 |
|
| 2020 |
Sacco MD, Ma C, Lagarias P, Gao A, Townsend JA, Meng X, Dube P, Zhang X, Hu Y, Kitamura N, Hurst B, Tarbet B, Marty MT, Kolocouris A, Xiang Y, et al. Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against M and cathepsin L. Science Advances. PMID 33158912 DOI: 10.1126/sciadv.abe0751 |
0.31 |
|
| 2020 |
Ma C, Hu Y, Townsend JA, Lagarias PI, Marty MT, Kolocouris A, Wang J. Ebselen, disulfiram, carmofur, PX-12, tideglusib, and shikonin are non-specific promiscuous SARS-CoV-2 main protease inhibitors. Biorxiv : the Preprint Server For Biology. PMID 32995786 DOI: 10.1101/2020.09.15.299164 |
0.349 |
|
| 2020 |
Musharrafieh R, Lagarias P, Ma C, Hau R, Romano A, Lambrinidis G, Kolocouris A, Wang J. Investigation of the Drug Resistance Mechanism of M2-S31N Channel Blockers through Biomolecular Simulations and Viral Passage Experiments. Acs Pharmacology & Translational Science. 3: 666-675. PMID 32832869 DOI: 10.1021/acsptsci.0c00018 |
0.424 |
|
| 2020 |
Tzitzoglaki C, McGuire K, Lagarias P, Konstantinidi A, Hoffmann A, Fokina NA, Ma C, Papanastasiou IP, Schreiner PR, Vazquez S, Schmidtke M, Wang J, Busath DD, Kolocouris A. Chemical Probes for Blocking of Influenza A M2 WT and S31N Channels. Acs Chemical Biology. PMID 32786258 DOI: 10.1021/Acschembio.0C00553 |
0.459 |
|
| 2020 |
Sacco MD, Ma C, Lagarias P, Gao A, Townsend JA, Meng X, Dube P, Zhang X, Hu Y, Kitamura N, Hurst B, Tarbet B, Marty MT, Kolocouris A, Xiang Y, et al. Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against M and cathepsin L. Biorxiv : the Preprint Server For Biology. PMID 32766590 DOI: 10.1101/2020.07.27.223727 |
0.312 |
|
| 2020 |
Ma C, Hu Y, Zhang J, Wang J. Pharmacological characterization of the mechanism of action of R523062, a promising antiviral for enterovirus D68. Acs Infectious Diseases. PMID 32692536 DOI: 10.1021/Acsinfecdis.0C00383 |
0.364 |
|
| 2020 |
Ma C, Sacco MD, Hurst B, Townsend JA, Hu Y, Szeto T, Zhang X, Tarbet B, Marty MT, Chen Y, Wang J. Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease. Cell Research. PMID 32541865 DOI: 10.1038/S41422-020-0356-Z |
0.439 |
|
| 2020 |
Cai S, Tuohy P, Ma C, Kitamura N, Gomez K, Zhou Y, Ran D, Bellampalli SS, Yu J, Luo S, Dorame A, Ngan Pham NY, Molnar G, Streicher JM, Patek M, et al. A modulator of the low-voltage activated T-type calcium channel that reverses HIV glycoprotein 120-, paclitaxel-, and spinal nerve ligation-induced peripheral neuropathies. Pain. PMID 32541387 DOI: 10.1097/J.Pain.0000000000001955 |
0.306 |
|
| 2020 |
Ma C, Sacco MD, Hurst B, Townsend JA, Hu Y, Szeto T, Zhang X, Tarbet B, Marty MT, Chen Y, Wang J. Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease. Biorxiv : the Preprint Server For Biology. PMID 32511378 DOI: 10.1101/2020.04.20.051581 |
0.34 |
|
| 2019 |
Musharrafieh R, Ma C, Wang J. Discovery of M2 channel blockers targeting the drug-resistant double mutants M2-S31N/L26I and M2-S31N/V27A from the influenza A viruses. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 105124. PMID 31669761 DOI: 10.1016/J.Ejps.2019.105124 |
0.529 |
|
| 2019 |
Ma C, Hu Y, Zhang J, Musharrafieh R, Wang J. A Novel Capsid Binding Inhibitor Displays Potent Antiviral Activity against Enterovirus D68. Acs Infectious Diseases. PMID 31532189 DOI: 10.1021/Acsinfecdis.9B00284 |
0.366 |
|
| 2019 |
Musharrafieh R, Lagarias P, Ma C, Tan G, Kolocouris A, Wang J. The L46P mutant confers a novel allosteric mechanism of resistance towards the influenza A virus M2 S31N proton channel blockers. Molecular Pharmacology. PMID 31175183 DOI: 10.1124/Mol.119.116640 |
0.366 |
|
| 2019 |
Zhang J, Hu Y, Hau R, Musharrafieh R, Ma C, Zhou X, Chen Y, Wang J. Identification of NMS-873, an allosteric and specific p97 inhibitor, as a broad antiviral against both influenza A and B viruses. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 133: 86-94. PMID 30930289 DOI: 10.1016/J.Ejps.2019.03.020 |
0.43 |
|
| 2019 |
Musharrafieh R, Ma C, Zhang J, Hu Y, Diesing JM, Marty MT, Wang J. Validating Enterovirus D68-2A as an Antiviral Drug Target and the Discovery of Telaprevir as a Potent D68-2A Inhibitor. Journal of Virology. PMID 30674624 DOI: 10.1128/Jvi.02221-18 |
0.31 |
|
| 2018 |
Hu Y, Hau RK, Wang Y, Tuohy P, Zhang Y, Xu S, Ma C, Wang J. Structure-Property Relationship Studies of Influenza A Virus AM2-S31N Proton Channel Blockers. Acs Medicinal Chemistry Letters. 9: 1111-1116. PMID 30429954 DOI: 10.1021/Acsmedchemlett.8B00336 |
0.494 |
|
| 2018 |
Zhao X, Li R, Zhou Y, Xiao M, Ma C, Yang Z, Zeng S, Du Q, Yang C, Jiang H, Hu Y, Wang K, Mok CKP, Sun P, Dong J, et al. Discovery of Highly Potent Pinanamine-Based Inhibitors Against Amantadine- and Oseltamivir-resistant Influenza A Viruses. Journal of Medicinal Chemistry. PMID 29799746 DOI: 10.1021/Acs.Jmedchem.8B00042 |
0.478 |
|
| 2018 |
Mandour YM, Breitinger U, Ma C, Wang J, Boeckler FM, Breitinger HG, Zlotos DP. Symmetric dimeric adamantanes for exploring the structure of two viroporins: influenza virus M2 and hepatitis C virus p7. Drug Design, Development and Therapy. 12: 1019-1031. PMID 29750015 DOI: 10.2147/Dddt.S157104 |
0.46 |
|
| 2018 |
Zhang J, Hu Y, Foley C, Wang Y, Musharrafieh R, Xu S, Zhang Y, Ma C, Hulme C, Wang J. Exploring Ugi-Azide Four-Component Reaction Products for Broad-Spectrum Influenza Antivirals with a High Genetic Barrier to Drug Resistance. Scientific Reports. 8: 4653. PMID 29545578 DOI: 10.1038/S41598-018-22875-9 |
0.423 |
|
| 2018 |
Drakopoulos A, Tzitzoglaki C, McGuire K, Hoffmann A, Konstantinidi A, Kolokouris D, Ma C, Freudenberger K, Hutterer J, Gauglitz G, Wang J, Schmidtke M, Busath DD, Kolocouris A. Unraveling the Binding, Proton Blockage, and Inhibition of Influenza M2 WT and S31N by Rimantadine Variants. Acs Medicinal Chemistry Letters. 9: 198-203. PMID 29541360 DOI: 10.1021/Acsmedchemlett.7B00458 |
0.462 |
|
| 2018 |
Musharrafieh R, Ma C, Wang J. Profiling the in vitro drug-resistance mechanism of influenza A viruses towards the AM2-S31N proton channel blockers. Antiviral Research. PMID 29518414 DOI: 10.1016/J.Antiviral.2018.03.002 |
0.466 |
|
| 2018 |
Wang Y, Hu Y, Xu S, Zhang Y, Musharrafieh R, Hau RK, Ma C, Wang J. In Vitro Pharmacokinetic Optimizations of AM2-S31N Channel Blockers Led to the Discovery of Slow-Binding Inhibitors with Potent Antiviral Activity against Drug-Resistant Influenza A Viruses. Journal of Medicinal Chemistry. PMID 29341607 DOI: 10.1021/Acs.Jmedchem.7B01536 |
0.467 |
|
| 2017 |
Ma C, Wang J. Functional studies reveal the similarities and differences between AM2 and BM2 proton channels from influenza viruses. Biochimica Et Biophysica Acta. PMID 29106970 DOI: 10.1016/J.Bbamem.2017.10.026 |
0.393 |
|
| 2017 |
Hu Y, Zhang J, Musharrafieh R, Hau R, Ma C, Wang J. Chemical Genomics Approach Leads to the Identification of Hesperadin, an Aurora B Kinase Inhibitor, as a Broad-Spectrum Influenza Antiviral. International Journal of Molecular Sciences. 18. PMID 28885544 DOI: 10.3390/Ijms18091929 |
0.435 |
|
| 2017 |
Hu Y, Zhang J, Musharrafieh RG, Ma C, Hau R, Wang J. Discovery of dapivirine, a nonnucleoside HIV-1 reverse transcriptase inhibitor, as a broad-spectrum antiviral against both influenza A and B viruses. Antiviral Research. PMID 28778830 DOI: 10.1016/J.Antiviral.2017.07.016 |
0.432 |
|
| 2017 |
Hu Y, Wang Y, Li F, Ma C, Wang J. Design and expeditious synthesis of organosilanes as potent antivirals targeting multidrug-resistant influenza A viruses. European Journal of Medicinal Chemistry. 135: 70-76. PMID 28433777 DOI: 10.1016/J.Ejmech.2017.04.038 |
0.464 |
|
| 2017 |
Li F, Hu Y, Wang Y, Ma C, Wang J. Expeditious Lead Optimization of Isoxazole-Containing Influenza A Virus M2-S31N Inhibitors Using the Suzuki-Miyaura Cross-Coupling Reaction. Journal of Medicinal Chemistry. PMID 28182419 DOI: 10.1021/Acs.Jmedchem.6B01852 |
0.479 |
|
| 2017 |
Hu Y, Musharrafieh R, Ma C, Zhang J, Smee DF, DeGrado WF, Wang J. An M2-V27A channel blocker demonstrates potent in vitro and in vivo antiviral activities against amantadine-sensitive and -resistant influenza A viruses. Antiviral Research. PMID 28087313 DOI: 10.1016/J.Antiviral.2017.01.006 |
0.519 |
|
| 2016 |
Li F, Ma C, Hu Y, Wang Y, Wang J. Discovery of Potent Antivirals against Amantadine-Resistant Influenza A Viruses by Targeting the M2-S31N Proton Channel. Acs Infectious Diseases. PMID 27657178 DOI: 10.1021/Acsinfecdis.6B00130 |
0.526 |
|
| 2016 |
Ma C, Li F, Musharrafieh R, Wang J. Discovery of cyclosporine A and its analogs as broad-spectrum anti-influenza drugs with a high in vitro genetic barrier of drug resistance. Antiviral Research. PMID 27478032 DOI: 10.1016/J.Antiviral.2016.07.019 |
0.451 |
|
| 2016 |
Ma C, Zhang J, Wang J. Pharmacological characterizations of the spectrum of antiviral activity and genetic barrier of drug resistance of M2-S31N channel blockers. Molecular Pharmacology. PMID 27385729 DOI: 10.1124/Mol.116.105346 |
0.494 |
|
| 2016 |
Li F, Ma C, DeGrado WF, Wang J. Discovery of highly potent inhibitors targeting the predominant drug-resistant S31N mutant of the influenza A virus M2 proton channel. Journal of Medicinal Chemistry. PMID 26771709 DOI: 10.1021/Acs.Jmedchem.5B01910 |
0.516 |
|
| 2015 |
Wang J, Li F, Ma C. Recent Progress in Designing Inhibitors That Target the Drug-resistant M2 Proton Channels from the Influenza A Viruses. Biopolymers. PMID 25663018 DOI: 10.1002/Bip.22623 |
0.48 |
|
| 2014 |
Wu Y, Canturk B, Jo H, Ma C, Gianti E, Klein ML, Pinto LH, Lamb RA, Fiorin G, Wang J, DeGrado WF. Flipping in the pore: discovery of dual inhibitors that bind in different orientations to the wild-type versus the amantadine-resistant S31N mutant of the influenza A virus M2 proton channel. Journal of the American Chemical Society. 136: 17987-95. PMID 25470189 DOI: 10.1021/Ja508461M |
0.525 |
|
| 2014 |
Rey-Carrizo M, Barniol-Xicota M, Ma C, Frigolé-Vivas M, Torres E, Naesens L, Llabrés S, Juárez-Jiménez J, Luque FJ, DeGrado WF, Lamb RA, Pinto LH, Vázquez S. Easily accessible polycyclic amines that inhibit the wild-type and amantadine-resistant mutants of the M2 channel of influenza A virus. Journal of Medicinal Chemistry. 57: 5738-47. PMID 24941437 DOI: 10.1021/Jm5005804 |
0.496 |
|
| 2013 |
Rey-Carrizo M, Torres E, Ma C, Barniol-Xicota M, Wang J, Wu Y, Naesens L, DeGrado WF, Lamb RA, Pinto LH, Vázquez S. 3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant. Journal of Medicinal Chemistry. 56: 9265-74. PMID 24237039 DOI: 10.1021/Jm401340P |
0.481 |
|
| 2013 |
Ma C, Fiorin G, Carnevale V, Wang J, Lamb RA, Klein ML, Wu Y, Pinto LH, DeGrado WF. Asp44 stabilizes the Trp41 gate of the M2 proton channel of influenza A virus. Structure (London, England : 1993). 21: 2033-41. PMID 24139991 DOI: 10.1016/J.Str.2013.08.029 |
0.46 |
|
| 2013 |
Roberts KL, Leser GP, Ma C, Lamb RA. The amphipathic helix of influenza A virus M2 protein is required for filamentous bud formation and scission of filamentous and spherical particles. Journal of Virology. 87: 9973-82. PMID 23843641 DOI: 10.1128/Jvi.01363-13 |
0.452 |
|
| 2013 |
Torres E, Duque MD, Vanderlinden E, Ma C, Pinto LH, Camps P, Froeyen M, Vázquez S, Naesens L. Role of the viral hemagglutinin in the anti-influenza virus activity of newly synthesized polycyclic amine compounds. Antiviral Research. 99: 281-91. PMID 23800838 DOI: 10.1016/J.Antiviral.2013.06.006 |
0.497 |
|
| 2013 |
Wang J, Ma C, Wang J, Jo H, Canturk B, Fiorin G, Pinto LH, Lamb RA, Klein ML, DeGrado WF. Discovery of novel dual inhibitors of the wild-type and the most prevalent drug-resistant mutant, S31N, of the M2 proton channel from influenza A virus. Journal of Medicinal Chemistry. 56: 2804-12. PMID 23437766 DOI: 10.1021/Jm301538E |
0.523 |
|
| 2013 |
Balgi AD, Wang J, Cheng DY, Ma C, Pfeifer TA, Shimizu Y, Anderson HJ, Pinto LH, Lamb RA, DeGrado WF, Roberge M. Inhibitors of the influenza A virus M2 proton channel discovered using a high-throughput yeast growth restoration assay. Plos One. 8: e55271. PMID 23383318 DOI: 10.1371/Journal.Pone.0055271 |
0.492 |
|
| 2013 |
Wang J, Wu Y, Ma C, Fiorin G, Wang J, Pinto LH, Lamb RA, Klein ML, Degrado WF. Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus. Proceedings of the National Academy of Sciences of the United States of America. 110: 1315-20. PMID 23302696 DOI: 10.1073/Pnas.1216526110 |
0.525 |
|
| 2012 |
Torres E, Duque MD, López-Querol M, Taylor MC, Naesens L, Ma C, Pinto LH, Sureda FX, Kelly JM, Vázquez S. Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities. Bioorganic & Medicinal Chemistry. 20: 942-8. PMID 22178660 DOI: 10.1016/J.Bmc.2011.11.050 |
0.331 |
|
| 2012 |
Fiorin G, Carnevale V, Wang J, Ma C, Wang T, Hu F, Lamb R, Pinto L, Hong M, DeGrado W, Klein M. Mapping Water Density to Design New Blockers Against a Viral Proton Channel Biophysical Journal. 102: 682a. DOI: 10.1016/J.Bpj.2011.11.3708 |
0.482 |
|
| 2011 |
Wang J, Ma C, Wu Y, Lamb RA, Pinto LH, DeGrado WF. Exploring organosilane amines as potent inhibitors and structural probes of influenza a virus M2 proton channel. Journal of the American Chemical Society. 133: 13844-7. PMID 21819109 DOI: 10.1021/Ja2050666 |
0.532 |
|
| 2011 |
Wang J, Ma C, Fiorin G, Carnevale V, Wang T, Hu F, Lamb RA, Pinto LH, Hong M, Klein ML, DeGrado WF. Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2. Journal of the American Chemical Society. 133: 12834-41. PMID 21744829 DOI: 10.1021/Ja204969M |
0.492 |
|
| 2011 |
Wang J, Ma C, Balannik V, Pinto LH, Lamb RA, Degrado WF. Exploring the Requirements for the Hydrophobic Scaffold and Polar Amine in inhibitors of M2 from Influenza A Virus. Acs Medicinal Chemistry Letters. 2: 307-312. PMID 21691418 DOI: 10.1021/Ml100297W |
0.485 |
|
| 2011 |
Duque MD, Ma C, Torres E, Wang J, Naesens L, Juárez-Jiménez J, Camps P, Luque FJ, DeGrado WF, Lamb RA, Pinto LH, Vázquez S. Exploring the size limit of templates for inhibitors of the M2 ion channel of influenza A virus. Journal of Medicinal Chemistry. 54: 2646-57. PMID 21466220 DOI: 10.1021/Jm101334Y |
0.513 |
|
| 2010 |
Polishchuk AL, Lear JD, Ma C, Lamb RA, Pinto LH, Degrado WF. A pH-dependent conformational ensemble mediates proton transport through the influenza A/M2 protein. Biochemistry. 49: 10061-71. PMID 20968306 DOI: 10.1021/Bi101229M |
0.372 |
|
| 2010 |
Ma C, Ohigashi Y, Jing X, Lamb RA, Pinto LH. Pharmacological Relevant Amantadine Binding Site is in the Pore of Influenza a Virus M2 Proton Channel Biophysical Journal. 98: 539a. DOI: 10.1016/J.Bpj.2009.12.2926 |
0.537 |
|
| 2009 |
Ohigashi Y, Ma C, Jing X, Balannick V, Pinto LH, Lamb RA. An amantadine-sensitive chimeric BM2 ion channel of influenza B virus has implications for the mechanism of drug inhibition. Proceedings of the National Academy of Sciences of the United States of America. 106: 18775-9. PMID 19841275 DOI: 10.1073/Pnas.0910584106 |
0.524 |
|
| 2009 |
Ma C, Polishchuk AL, Ohigashi Y, Stouffer AL, Schön A, Magavern E, Jing X, Lear JD, Freire E, Lamb RA, DeGrado WF, Pinto LH. Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel. Proceedings of the National Academy of Sciences of the United States of America. 106: 12283-8. PMID 19590009 DOI: 10.1073/Pnas.0905726106 |
0.51 |
|
| 2009 |
Ma C, Polishchuk A, Ohigashi Y, DeGrado WF, Lamb RA, Pinto LH. Determining the Functional Core for Proton Transport, Ion Selectivity and Amantadine Sensitivity of the A/M2 Protein from Influenza A Virus Biophysical Journal. 96: 668a. DOI: 10.1016/J.Bpj.2008.12.3529 |
0.504 |
|
| 2008 |
Nguyen PA, Soto CS, Polishchuk A, Caputo GA, Tatko CD, Ma C, Ohigashi Y, Pinto LH, DeGrado WF, Howard KP. pH-induced conformational change of the influenza M2 protein C-terminal domain. Biochemistry. 47: 9934-6. PMID 18754675 DOI: 10.1021/Bi801315M |
0.401 |
|
| 2008 |
Jing X, Ma C, Ohigashi Y, Oliveira FA, Jardetzky TS, Pinto LH, Lamb RA. Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel. Proceedings of the National Academy of Sciences of the United States of America. 105: 10967-72. PMID 18669647 DOI: 10.1073/Pnas.0804958105 |
0.5 |
|
| 2008 |
Stouffer AL, Ma C, Cristian L, Ohigashi Y, Lamb RA, Lear JD, Pinto LH, DeGrado WF. The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza A virus. Structure (London, England : 1993). 16: 1067-76. PMID 18611380 DOI: 10.1016/J.Str.2008.04.011 |
0.504 |
|
| 2008 |
Ma C, Soto CS, Ohigashi Y, Taylor A, Bournas V, Glawe B, Udo MK, Degrado WF, Lamb RA, Pinto LH. Identification of the pore-lining residues of the BM2 ion channel protein of influenza B virus. The Journal of Biological Chemistry. 283: 15921-31. PMID 18408016 DOI: 10.1074/Jbc.M710302200 |
0.488 |
|
| 2007 |
Ma C, Remani S, Sun J, Kotaria R, Mayor JA, Walters DE, Kaplan RS. Identification of the substrate binding sites within the yeast mitochondrial citrate transport protein. The Journal of Biological Chemistry. 282: 17210-20. PMID 17400551 DOI: 10.1074/Jbc.M611268200 |
0.649 |
|
| 2006 |
Ma C, Remani S, Kotaria R, Mayor JA, Walters DE, Kaplan RS. The mitochondrial citrate transport protein: evidence for a steric interaction between glutamine 182 and leucine 120 and its relationship to the substrate translocation pathway and identification of other mechanistically essential residues. Biochimica Et Biophysica Acta. 1757: 1271-6. PMID 16904062 DOI: 10.1016/J.Bbabio.2006.06.011 |
0.594 |
|
| 2005 |
Ma C, Kotaria R, Mayor JA, Remani S, Walters DE, Kaplan RS. The yeast mitochondrial citrate transport protein: characterization of transmembrane domain III residue involvement in substrate translocation. The Journal of Biological Chemistry. 280: 2331-40. PMID 15498760 DOI: 10.1074/Jbc.M411474200 |
0.607 |
|
| 2004 |
Ma C, Kotaria R, Mayor JA, Eriks LR, Dean AM, Walters DE, Kaplan RS. The mitochondrial citrate transport protein: probing the secondary structure of transmembrane domain III, identification of residues that likely comprise a portion of the citrate transport pathway, and development of a model for the putative TMDIII-TMDIII' interface. The Journal of Biological Chemistry. 279: 1533-40. PMID 14561747 DOI: 10.1074/Jbc.M310866200 |
0.566 |
|
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