| Year |
Citation |
Score |
| 2019 |
Li Y, Li QY, Ling QL, So SP, Ruan KH. A novel single-chain enzyme complex with chain reaction properties rapidly producing thromboxane A and exhibiting powerful anti-bleeding functions. Journal of Cellular and Molecular Medicine. PMID 31628732 DOI: 10.1111/Jcmm.14711 |
0.318 |
|
| 2018 |
Li Y, Xu A, Ling Q, Ruan KH. Advances in extracellular ligand recognition sites on prostanoid receptors. Future Medicinal Chemistry. PMID 29673264 DOI: 10.4155/Fmc-2017-0319 |
0.356 |
|
| 2017 |
Akasaka H, Thaliachery N, Zheng X, Blumenthal M, Nikhar S, Murdoch EE, Ling Q, Ruan KH. The key residue within the second extracellular loop of human EP3 involved in selectively turning down PGE2-and retaining PGE1-mediated signaling in live cells. Archives of Biochemistry and Biophysics. PMID 28065721 DOI: 10.1016/J.Abb.2016.12.001 |
0.349 |
|
| 2011 |
Chen Y, Fujita T, Zhang D, Doan H, Pinkaew D, Liu Z, Wu J, Koide Y, Chiu A, Lin CC, Chang JY, Ruan KH, Fujise K. Physical and functional antagonism between tumor suppressor protein p53 and fortilin, an anti-apoptotic protein. The Journal of Biological Chemistry. 286: 32575-85. PMID 21795694 DOI: 10.1074/jbc.M110.217836 |
0.413 |
|
| 2011 |
Mohite A, Chillar A, So SP, Cervantes V, Ruan KH. Novel mechanism of the vascular protector prostacyclin: regulating microRNA expression. Biochemistry. 50: 1691-9. PMID 21250659 DOI: 10.1021/Bi101654W |
0.306 |
|
| 2010 |
Chillar A, Wu J, Cervantes V, Ruan KH. Structural and functional analysis of the C-terminus of Galphaq in complex with the human thromboxane A2 receptor provides evidence of constitutive activity. Biochemistry. 49: 6365-74. PMID 20590159 DOI: 10.1021/Bi100047N |
0.613 |
|
| 2010 |
Chillar A, Wu J, Cervantes V, Ruan K. Characterization Of The Ligand-Free Constitutive Activity Of The Thromboxane A2 Receptor By The Integrated Approaches Of Nmr Spectroscopy And A Recombinant Receptor Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr20112 |
0.388 |
|
| 2009 |
Ruan KH, Cervantes V, So SP. Engineering of a novel hybrid enzyme: an anti-inflammatory drug target with triple catalytic activities directly converting arachidonic acid into the inflammatory prostaglandin E2. Protein Engineering, Design & Selection : Peds. 22: 733-40. PMID 19850676 DOI: 10.1093/Protein/Gzp058 |
0.33 |
|
| 2009 |
Ruan KH, Cervantes V, Wu J. Ligand-specific conformation determines agonist activation and antagonist blockade in purified human thromboxane A2 receptor. Biochemistry. 48: 3157-65. PMID 19170518 DOI: 10.1021/Bi801443G |
0.598 |
|
| 2008 |
Ruan KH, So SP, Wu H, Cervantes V. Large-scale expression, purification, and characterization of an engineered prostacyclin-synthesizing enzyme with therapeutic potential. Archives of Biochemistry and Biophysics. 480: 41-50. PMID 18835243 DOI: 10.1016/J.Abb.2008.09.010 |
0.332 |
|
| 2008 |
Chillar A, Wu J, So SP, Ruan KH. Involvement of non-conserved residues important for PGE2 binding to the constrained EP3 eLP2 using NMR and site-directed mutagenesis. Febs Letters. 582: 2863-8. PMID 18652829 DOI: 10.1016/J.Febslet.2008.07.018 |
0.605 |
|
| 2008 |
Ruan KH, Wijaya C, Cervantes V, Wu J. Characterization of the prostaglandin H2 mimic: binding to the purified human thromboxane A2 receptor in solution. Archives of Biochemistry and Biophysics. 477: 396-403. PMID 18590695 DOI: 10.1016/J.Abb.2008.05.022 |
0.592 |
|
| 2008 |
Ruan KH, Cervantes V, Wu J. A simple, quick, and high-yield preparation of the human thromboxane A2 receptor in full size for structural studies. Biochemistry. 47: 6819-26. PMID 18529068 DOI: 10.1021/Bi702501G |
0.573 |
|
| 2008 |
Ruan KH, Wu J, Cervantes V. Characterization of the substrate mimic bound to engineered prostacyclin synthase in solution using high-resolution NMR spectroscopy and mutagenesis: implication of the molecular mechanism in biosynthesis of prostacyclin. Biochemistry. 47: 680-8. PMID 18081314 DOI: 10.1021/Bi701671Q |
0.566 |
|
| 2008 |
Wu J, Feng M, Ruan KH. Assembling NMR structures for the intracellular loops of the human thromboxane A2 receptor: implication of the G protein-coupling pocket. Archives of Biochemistry and Biophysics. 470: 73-82. PMID 18073117 DOI: 10.1016/J.Abb.2007.11.016 |
0.62 |
|
| 2008 |
Ni F, So SP, Cervantes V, Ruan KH. A profile of the residues in the second extracellular loop that are critical for ligand recognition of human prostacyclin receptor. The Febs Journal. 275: 128-37. PMID 18042246 DOI: 10.1111/J.1742-4658.2007.06183.X |
0.466 |
|
| 2006 |
Ruan KH, Deng H, So SP. Engineering of a protein with cyclooxygenase and prostacyclin synthase activities that converts arachidonic acid to prostacyclin. Biochemistry. 45: 14003-11. PMID 17115695 DOI: 10.1021/Bi0614277 |
0.336 |
|
| 2006 |
Zhang L, Bastepe M, Jüppner H, Ruan KH. Characterization of the molecular mechanisms of the coupling between intracellular loops of prostacyclin receptor with the C-terminal domain of the Galphas protein in human coronary artery smooth muscle cells. Archives of Biochemistry and Biophysics. 454: 80-8. PMID 16942748 DOI: 10.1016/J.Abb.2006.06.023 |
0.543 |
|
| 2006 |
Ruan KH, Dogné JM. Implications of the molecular basis of prostacyclin biosynthesis and signaling in pharmaceutical designs. Current Pharmaceutical Design. 12: 925-41. PMID 16533160 DOI: 10.2174/138161206776055994 |
0.365 |
|
| 2006 |
Dogné JM, Hanson J, de Leval X, Pratico D, Pace-Asciak CR, Drion P, Pirotte B, Ruan KH. From the design to the clinical application of thromboxane modulators. Current Pharmaceutical Design. 12: 903-23. PMID 16533159 DOI: 10.2174/138161206776055921 |
0.304 |
|
| 2006 |
Zhang L, Wu J, Ruan KH. Solution structure of the first intracellular loop of prostacyclin receptor and implication of its interaction with the C-terminal segment of G alpha s protein. Biochemistry. 45: 1734-44. PMID 16460020 DOI: 10.1021/Bi0515669 |
0.61 |
|
| 2005 |
Ruan KH, Wu J, Wang LH. Solution structure of a common substrate mimetic of cyclooxygenase-downstream synthases bound to an engineered thromboxane A2 synthase using a high-resolution NMR technique. Archives of Biochemistry and Biophysics. 444: 165-73. PMID 16297851 DOI: 10.1016/J.Abb.2005.10.010 |
0.565 |
|
| 2005 |
Ruan CH, Wu J, Ruan KH. A strategy using NMR peptide structures of thromboxane A2 receptor as templates to construct ligand-recognition pocket of prostacyclin receptor. Bmc Biochemistry. 6: 23. PMID 16271145 DOI: 10.1186/1471-2091-6-23 |
0.567 |
|
| 2005 |
Zhang L, Huang G, Wu J, Ruan KH. A profile of the residues in the first intracellular loop critical for Gs-mediated signaling of human prostacyclin receptor characterized by an integrative approach of NMR-experiment and mutagenesis. Biochemistry. 44: 11389-401. PMID 16114876 DOI: 10.1021/Bi050483P |
0.65 |
|
| 2005 |
Ruan KH, Deng H, Wu J, So SP. The N-terminal membrane anchor domain of the membrane-bound prostacyclin synthase involved in the substrate presentation of the coupling reaction with cyclooxygenase. Archives of Biochemistry and Biophysics. 435: 372-81. PMID 15708381 DOI: 10.1016/J.Abb.2004.12.018 |
0.518 |
|
| 2004 |
Ruan KH, Wu J, So SP, Jenkins LA, Ruan CH. NMR structure of the thromboxane A2 receptor ligand recognition pocket. European Journal of Biochemistry / Febs. 271: 3006-16. PMID 15233797 DOI: 10.1111/J.1432-1033.2004.04232.X |
0.596 |
|
| 2004 |
Geng L, Wu J, So SP, Huang G, Ruan KH. Structural and functional characterization of the first intracellular loop of human thromboxane A2 receptor. Archives of Biochemistry and Biophysics. 423: 253-65. PMID 15001390 DOI: 10.1016/J.Abb.2004.01.001 |
0.621 |
|
| 2003 |
Ruan KH, Wu J, So SP, Jenkins LA. Evidence of the residues involved in ligand recognition in the second extracellular loop of the prostacyclin receptor characterized by high resolution 2D NMR techniques. Archives of Biochemistry and Biophysics. 418: 25-33. PMID 13679079 DOI: 10.1016/S0003-9861(03)00401-6 |
0.622 |
|
| 2003 |
Wu J, So SP, Ruan KH. Solution structure of the third extracellular loop of human thromboxane A2 receptor. Archives of Biochemistry and Biophysics. 414: 287-93. PMID 12781781 |
0.592 |
|
| 2003 |
Deng H, Wu J, So SP, Ruan KH. Identification of the residues in the helix F/G loop important to catalytic function of membrane-bound prostacyclin synthase. Biochemistry. 42: 5609-17. PMID 12741817 DOI: 10.1021/Bi026749Z |
0.57 |
|
| 2003 |
Wu J, So SP, Ruan KH. Determination of the membrane contact residues and solution structure of the helix F/G loop of prostaglandin I2 synthase. Archives of Biochemistry and Biophysics. 411: 27-35. PMID 12590920 |
0.512 |
|
| 2003 |
So SP, Wu J, Huang G, Huang A, Li D, Ruan KH. Identification of residues important for ligand binding of thromboxane A2 receptor in the second extracellular loop using the NMR experiment-guided mutagenesis approach. The Journal of Biological Chemistry. 278: 10922-7. PMID 12551898 DOI: 10.1074/Jbc.M209337200 |
0.62 |
|
| 2002 |
Ruan KH, So SP, Zheng W, Wu J, Li D, Kung J. Solution structure and topology of the N-terminal membrane anchor domain of a microsomal cytochrome P450: prostaglandin I2 synthase. The Biochemical Journal. 368: 721-8. PMID 12193162 DOI: 10.1042/Bj20021001 |
0.559 |
|
| 2002 |
Deng H, Huang A, So SP, Lin YZ, Ruan KH. Substrate access channel topology in membrane-bound prostacyclin synthase. The Biochemical Journal. 362: 545-51. PMID 11879180 DOI: 10.1042/0264-6021:3620545 |
0.345 |
|
| 2001 |
Ruan KH, So SP, Wu J, Li D, Huang A, Kung J. Solution structure of the second extracellular loop of human thromboxane A2 receptor. Biochemistry. 40: 275-80. PMID 11141080 DOI: 10.1021/Bi001867C |
0.632 |
|
| 2000 |
So S, Li D, Ruan K. Identification of the Substrate Interaction Site in the N-terminal Membrane Anchor Segment of Thromboxane A2Synthase by Determination of Its Substrate Analog Conformational Changes Using High Resolution NMR Technique Journal of Biological Chemistry. 275: 40679-40685. PMID 11006279 DOI: 10.1074/Jbc.M005752200 |
0.389 |
|
| 2000 |
Lin Y, Deng H, Ruan K. Topology of Catalytic Portion of Prostaglandin I2 Synthase: Identification by Molecular Modeling-Guided Site-Specific Antibodies Archives of Biochemistry and Biophysics. 379: 188-197. PMID 10898934 DOI: 10.1006/Abbi.2000.1892 |
0.38 |
|
| 1998 |
Ruan K, Li D, Ji J, Lin Y, Gao X. Structural characterization and topology of the second potential membrane anchor region in the thromboxane A2 synthase amino-terminal domain. Biochemistry. 37: 822-830. PMID 9454571 DOI: 10.1021/Bi971881Y |
0.392 |
|
| 1997 |
Ren Y, Walker C, Ruan K, Kulmacz RJ. Examination of Prostaglandin H Synthase-1 Topology in the Endoplasmic Reticulum Membrane Advances in Experimental Medicine and Biology. 171-5. PMID 9547554 DOI: 10.1007/978-1-4615-5325-0_25 |
0.355 |
|
| 1995 |
Ren Y, Walker C, Loose-Mitchell DS, Deng J, Ruan K, Kulmacz RJ. Topology of prostaglandin H synthase-1 in the endoplasmic reticulum membrane. Archives of Biochemistry and Biophysics. 323: 205-214. PMID 7487068 DOI: 10.1006/Abbi.1995.0027 |
0.36 |
|
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