| Year |
Citation |
Score |
| 2016 |
Whicker ME, Lin ZP, Hanna R, Sartorelli AC, Ratner ES. MK-2206 sensitizes BRCA-deficient epithelial ovarian adenocarcinoma to cisplatin and olaparib. Bmc Cancer. 16: 550. PMID 27465688 DOI: 10.1186/S12885-016-2598-1 |
0.322 |
|
| 2015 |
Shyam K, Penketh PG, Baumann RP, Finch RA, Zhu R, Zhu YL, Sartorelli AC. Antitumor sulfonylhydrazines: Design, structure-activity relationships, resistance mechanisms, and strategies for improving therapeutic utility Journal of Medicinal Chemistry. 58: 3639-3671. PMID 25612194 DOI: 10.1021/Jm501459C |
0.407 |
|
| 2014 |
Ishiguro K, Lin ZP, Penketh PG, Shyam K, Zhu R, Baumann RP, Zhu YL, Sartorelli AC, Rutherford TJ, Ratner ES. Distinct mechanisms of cell-kill by triapine and its terminally dimethylated derivative Dp44mT due to a loss or gain of activity of their copper(II) complexes. Biochemical Pharmacology. 91: 312-22. PMID 25130544 DOI: 10.1016/J.Bcp.2014.08.006 |
0.432 |
|
| 2014 |
Penketh PG, Patridge E, Shyam K, Baumann RP, Zhu R, Ishiguro K, Sartorelli AC. Influence of glutathione and glutathione S-transferases on DNA interstrand cross-link formation by 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine, the active anticancer moiety generated by laromustine. Chemical Research in Toxicology. 27: 1440-9. PMID 25012050 DOI: 10.1021/Tx500197T |
0.4 |
|
| 2014 |
Penketh PG, Shyam K, Zhu R, Baumann RP, Ishiguro K, Sartorelli AC. Influence of phosphate and phosphoesters on the decomposition pathway of 1,2-bis(methylsulfonyl)-1-(2-chloroethyhydrazine (90CE), the active anticancer moiety generated by Laromustine, KS119, and KS119W. Chemical Research in Toxicology. 27: 818-33. PMID 24618018 DOI: 10.1021/Tx500004Y |
0.418 |
|
| 2014 |
Lin ZP, Ratner ES, Whicker ME, Lee Y, Sartorelli AC. Triapine disrupts CtIP-mediated homologous recombination repair and sensitizes ovarian cancer cells to PARP and topoisomerase inhibitors. Molecular Cancer Research : McR. 12: 381-93. PMID 24413181 DOI: 10.1158/1541-7786.Mcr-13-0480 |
0.353 |
|
| 2014 |
Lamb KL, Liu Y, Ishiguro K, Kwon Y, Paquet N, Sartorelli AC, Sung P, Rockwell S, Sweasy JB. Tumor-associated mutations in O6-methylguanine DNA-methyltransferase (MGMT) reduce DNA repair functionality Molecular Carcinogenesis. 53: 201-210. PMID 23065697 DOI: 10.1002/Mc.21964 |
0.391 |
|
| 2013 |
Ishiguro K, Shyam K, Penketh PG, Baumann RP, Sartorelli AC, Rutherford TJ, Ratner ES. Expression of O (6)-Methylguanine-DNA Methyltransferase Examined by Alkyl-Transfer Assays, Methylation-Specific PCR and Western Blots in Tumors and Matched Normal Tissue. Journal of Cancer Therapy. 4: 919-931. PMID 23946891 DOI: 10.4236/Jct.2013.44103 |
0.364 |
|
| 2013 |
Zhu R, Baumann RP, Patridge E, Penketh PG, Shyam K, Ishiguro K, Sartorelli AC. Chloroethylating and methylating dual function antineoplastic agents display superior cytotoxicity against repair proficient tumor cells. Bioorganic & Medicinal Chemistry Letters. 23: 1853-9. PMID 23395657 DOI: 10.1016/J.Bmcl.2013.01.016 |
0.408 |
|
| 2013 |
Zhu R, Baumann RP, Penketh PG, Shyam K, Sartorelli AC. Hypoxia-selective O6-alkylguanine-DNA alkyltransferase inhibitors: design, synthesis, and evaluation of 6-(benzyloxy)-2-(aryldiazenyl)-9H-purines as prodrugs of O6-benzylguanine. Journal of Medicinal Chemistry. 56: 1355-9. PMID 23311288 DOI: 10.1021/Jm301804P |
0.378 |
|
| 2013 |
Ratner ES, Whicker M, Lin ZP, Sartorelli AC. Abstract 4490: Triapine sensitizes chemoresistant ovarian cancer cells to platinum therapy. Cancer Research. 73: 4490-4490. DOI: 10.1158/1538-7445.Am2013-4490 |
0.386 |
|
| 2012 |
Zhu R, Seow HA, Baumann RP, Ishiguro K, Penketh PG, Shyam K, Sartorelli AC. Design of a hypoxia-activated prodrug inhibitor of O6-alkylguanine-DNA alkyltransferase. Bioorganic & Medicinal Chemistry Letters. 22: 6242-7. PMID 22932317 DOI: 10.1016/J.Bmcl.2012.08.008 |
0.77 |
|
| 2012 |
Kim EY, Liu Y, Akintujoye OM, Shyam K, Grove TA, Sartorelli AC, Rockwell S. Preliminary studies with a new hypoxia-selective cytotoxin, KS119W, in vitro and in vivo Radiation Research. 178: 126-137. PMID 22862779 DOI: 10.1667/Rr2934.1 |
0.464 |
|
| 2012 |
Patridge EV, Eriksson ES, Penketh PG, Baumann RP, Zhu R, Shyam K, Eriksson LA, Sartorelli AC. 7-Nitro-4-(phenylthio)benzofurazan is a potent generator of superoxide and hydrogen peroxide. Archives of Toxicology. 86: 1613-25. PMID 22669514 DOI: 10.1007/S00204-012-0872-9 |
0.364 |
|
| 2012 |
Penketh PG, Shyam K, Baumann RP, Ishiguro K, Patridge EV, Zhu R, Sartorelli AC. A strategy for selective O(6)-alkylguanine-DNA alkyltransferase depletion under hypoxic conditions. Chemical Biology & Drug Design. 80: 279-90. PMID 22553921 DOI: 10.1111/J.1747-0285.2012.01401.X |
0.363 |
|
| 2012 |
Rockwell S, Liu Y, Seow HA, Ishiguro K, Baumann RP, Penketh PG, Shyam K, Akintujoye OM, Glazer PM, Sartorelli AC. Preclinical evaluation of Laromustine for use in combination with radiation therapy in the treatment of solid tumors. International Journal of Radiation Biology. 88: 277-85. PMID 22111842 DOI: 10.3109/09553002.2012.638359 |
0.724 |
|
| 2012 |
Ratner E, Lin Z, Rutherford TJ, Azodi M, Santin A, Schwartz PE, Sartorelli A. Targeting the upregulation of the AKT pathway and homologous recombination repair as a therapeutic strategy for epithelial ovarian cancer. Journal of Clinical Oncology. 30: e13125-e13125. DOI: 10.1200/Jco.2012.30.15_Suppl.E13125 |
0.405 |
|
| 2012 |
Lin ZP, Ratner ES, Sartorelli AC. Abstract 2743: Triapine sensitizes ovarian cancer cells to platinum drugs and PARP inhibitors Cancer Research. 72: 2743-2743. DOI: 10.1158/1538-7445.Am2012-2743 |
0.355 |
|
| 2011 |
Zhu R, Liu MC, Luo MZ, Penketh PG, Baumann RP, Shyam K, Sartorelli AC. 4-nitrobenzyloxycarbonyl derivatives of O(6)-benzylguanine as hypoxia-activated prodrug inhibitors of O(6)-alkylguanine-DNA alkyltransferase (AGT), which produces resistance to agents targeting the O-6 position of DNA guanine. Journal of Medicinal Chemistry. 54: 7720-8. PMID 21955333 DOI: 10.1021/Jm201115F |
0.367 |
|
| 2011 |
Lin ZP, Lee Y, Lin F, Belcourt MF, Li P, Cory JG, Glazer PM, Sartorelli AC. Reduced level of ribonucleotide reductase R2 subunits increases dependence on homologous recombination repair of cisplatin-induced DNA damage. Molecular Pharmacology. 80: 1000-12. PMID 21875941 DOI: 10.1124/Mol.111.074708 |
0.329 |
|
| 2011 |
Penketh PG, Baumann RP, Shyam K, Williamson HS, Ishiguro K, Zhu R, Eriksson ES, Eriksson LA, Sartorelli AC. 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119): a cytotoxic prodrug with two stable conformations differing in biological and physical properties. Chemical Biology & Drug Design. 78: 513-26. PMID 21777394 DOI: 10.1111/J.1747-0285.2011.01193.X |
0.335 |
|
| 2011 |
Baumann RP, Ishiguro K, Penketh PG, Shyam K, Zhu R, Sartorelli AC. KS900: A hypoxia-directed, reductively activated methylating antitumor prodrug that selectively ablates O(6)-alkylguanine-DNA alkyltransferase in neoplastic cells. Biochemical Pharmacology. 81: 1201-10. PMID 21396917 DOI: 10.1016/J.Bcp.2011.02.019 |
0.456 |
|
| 2010 |
Ishiguro K, Zhu YL, Shyam K, Penketh PG, Baumann RP, Sartorelli AC. Quantitative relationship between guanine O(6)-alkyl lesions produced by Onrigin™ and tumor resistance by O(6)-alkylguanine-DNA alkyltransferase. Biochemical Pharmacology. 80: 1317-25. PMID 20654586 DOI: 10.1016/J.Bcp.2010.07.022 |
0.382 |
|
| 2010 |
Baumann RP, Penketh PG, Ishiguro K, Shyam K, Zhu YL, Sartorelli AC. Reductive activation of the prodrug 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119) selectively occurs in oxygen-deficient cells and overcomes O(6)-alkylguanine-DNA alkyltransferase mediated KS119 tumor cell resistance. Biochemical Pharmacology. 79: 1553-61. PMID 20005211 DOI: 10.1016/J.Bcp.2009.12.004 |
0.474 |
|
| 2009 |
Burkhart CA, Watt F, Murray J, Pajic M, Prokvolit A, Xue C, Flemming C, Smith J, Purmal A, Isachenko N, Komarov PG, Gurova KV, Sartorelli AC, Marshall GM, Norris MD, et al. Small-molecule multidrug resistance-associated protein 1 inhibitor reversan increases the therapeutic index of chemotherapy in mouse models of neuroblastoma. Cancer Research. 69: 6573-80. PMID 19654298 DOI: 10.1158/0008-5472.Can-09-1075 |
0.357 |
|
| 2009 |
Ishiguro K, Rice AM, Rice KP, Sartorelli AC. Inhibition of all-trans retinoic acid-induced granulocytic differentiation of WEHI-3B D+ cells by forced expression of SCL (TAL1) and GATA-1. Leukemia Research. 33: 1249-54. PMID 19230972 DOI: 10.1016/J.Leukres.2009.01.022 |
0.711 |
|
| 2008 |
Baumann RP, Penketh PG, Seow HA, Shyam K, Sartorelli AC. Generation of oxygen deficiency in cell culture using a two-enzyme system to evaluate agents targeting hypoxic tumor cells. Radiation Research. 170: 651-60. PMID 18959466 DOI: 10.1667/Rr1431.1 |
0.757 |
|
| 2008 |
Ishiguro K, Shyam K, Penketh PG, Sartorelli AC. Development of an O(6)-alkylguanine-DNA alkyltransferase assay based on covalent transfer of the benzyl moiety from [benzene-3H]O(6)-benzylguanine to the protein. Analytical Biochemistry. 383: 44-51. PMID 18783719 DOI: 10.1016/J.Ab.2008.08.009 |
0.405 |
|
| 2008 |
Bordonaro M, Lazarova DL, Sartorelli AC. Hyperinduction of Wnt activity: a new paradigm for the treatment of colorectal cancer? Oncology Research. 17: 1-9. PMID 18488710 DOI: 10.3727/096504008784046108 |
0.303 |
|
| 2008 |
Penketh PG, Baumann RP, Ishiguro K, Shyam K, Seow HA, Sartorelli AC. Lethality to leukemia cell lines of DNA interstrand cross-links generated by Cloretazine derived alkylating species. Leukemia Research. 32: 1546-53. PMID 18479747 DOI: 10.1016/J.Leukres.2008.03.005 |
0.76 |
|
| 2008 |
Lin ZP, Zhu YL, Johnson DR, Rice KP, Nottoli T, Hains BC, McGrath J, Waxman SG, Sartorelli AC. Disruption of cAMP and prostaglandin E2 transport by multidrug resistance protein 4 deficiency alters cAMP-mediated signaling and nociceptive response. Molecular Pharmacology. 73: 243-51. PMID 17959714 DOI: 10.1124/Mol.107.039594 |
0.711 |
|
| 2008 |
Ishiguro K, Sartorelli AC. Relationship between the induction of leukemia cell differentiation and the enhancement of reporter gene expression in 3T3 Swiss cells. Leukemia Research. 32: 89-96. PMID 17617452 DOI: 10.1016/J.Leukres.2007.05.011 |
0.348 |
|
| 2007 |
Bordonaro M, Lazarova DL, Sartorelli AC. The activation of beta-catenin by Wnt signaling mediates the effects of histone deacetylase inhibitors. Experimental Cell Research. 313: 1652-66. PMID 17359971 DOI: 10.1016/J.Yexcr.2007.02.008 |
0.333 |
|
| 2007 |
Lin ZP, Belcourt MF, Carbone R, Eaton JS, Penketh PG, Shadel GS, Cory JG, Sartorelli AC. Excess ribonucleotide reductase R2 subunits coordinate the S phase checkpoint to facilitate DNA damage repair and recovery from replication stress. Biochemical Pharmacology. 73: 760-72. PMID 17188250 DOI: 10.1016/J.Bcp.2006.11.014 |
0.317 |
|
| 2006 |
Cai J, Kirlin WG, Chen Y, Yan X, Jones DP, Sartorelli AC. Overexpression of heat shock factor 1 inhibits butyrate-induced differentiation in colon cancer cells. Cell Stress & Chaperones. 11: 199-207. PMID 17009592 DOI: 10.1379/Csc-180R.1 |
0.337 |
|
| 2006 |
Ishiguro K, Seow HA, Penketh PG, Shyam K, Sartorelli AC. Mode of action of the chloroethylating and carbamoylating moieties of the prodrug cloretazine. Molecular Cancer Therapeutics. 5: 969-76. PMID 16648568 DOI: 10.1158/1535-7163.Mct-05-0532 |
0.779 |
|
| 2006 |
Alvero AB, Chen W, Sartorelli AC, Schwartz P, Rutherford T, Mor G. Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone) induces apoptosis in ovarian cancer cells. Journal of the Society For Gynecologic Investigation. 13: 145-52. PMID 16443509 DOI: 10.1016/J.Jsgi.2005.11.004 |
0.371 |
|
| 2005 |
Baumann RP, Seow HA, Shyam K, Penketh PG, Sartorelli AC. The antineoplastic efficacy of the prodrug Cloretazine is produced by the synergistic interaction of carbamoylating and alkylating products of its activation. Oncology Research. 15: 313-25. PMID 16408696 DOI: 10.3727/096504005776404553 |
0.787 |
|
| 2005 |
Ishiguro K, Shyam K, Penketh PG, Sartorelli AC. Role of O6-alkylguanine-DNA alkyltransferase in the cytotoxic activity of cloretazine. Molecular Cancer Therapeutics. 4: 1755-63. PMID 16275997 DOI: 10.1158/1535-7163.Mct-05-0169 |
0.421 |
|
| 2005 |
Seow HA, Penketh PG, Shyam K, Rockwell S, Sartorelli AC. 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine: an anticancer agent targeting hypoxic cells. Proceedings of the National Academy of Sciences of the United States of America. 102: 9282-7. PMID 15964988 DOI: 10.1073/Pnas.0409013102 |
0.792 |
|
| 2005 |
Rice KP, Penketh PG, Shyam K, Sartorelli AC. Differential inhibition of cellular glutathione reductase activity by isocyanates generated from the antitumor prodrugs Cloretazine and BCNU. Biochemical Pharmacology. 69: 1463-72. PMID 15857610 DOI: 10.1016/J.Bcp.2005.02.016 |
0.74 |
|
| 2005 |
Seow HA, Belcourt MF, Penketh PG, Hodnick WF, Tomasz M, Rockwell S, Sartorelli AC. Nuclear localization of NADPH:cytochrome c (P450) reductase enhances the cytotoxicity of mitomycin C to Chinese hamster ovary cells. Molecular Pharmacology. 67: 417-23. PMID 15547247 DOI: 10.1124/Mol.104.004929 |
0.78 |
|
| 2004 |
Bordonaro M, Lazarova DL, Carbone R, Sartorelli AC. Modulation of Wnt-specific colon cancer cell kill by butyrate and lithium. Oncology Research. 14: 427-38. PMID 15490974 DOI: 10.3727/0965040041791428 |
0.353 |
|
| 2004 |
Rice AM, Holtz KM, Karp J, Rollins S, Sartorelli AC. Analysis of the relationship between Scl transcription factor complex protein expression patterns and the effects of LiCl on ATRA-induced differentiation in blast cells from patients with acute myeloid leukemia. Leukemia Research. 28: 1227-37. PMID 15380350 DOI: 10.1016/J.Leukres.2004.03.017 |
0.328 |
|
| 2004 |
Zeng H, Lin ZP, Sartorelli AC. Resistance to purine and pyrimidine nucleoside and nucleobase analogs by the human MDR1 transfected murine leukemia cell line L1210/VMDRC.06. Biochemical Pharmacology. 68: 911-21. PMID 15294454 DOI: 10.1016/J.Bcp.2004.06.004 |
0.373 |
|
| 2004 |
Ishiguro K, Sartorelli AC. Activation of transiently transfected reporter genes in 3T3 Swiss cells by the inducers of differentiation/apoptosis--dimethylsulfoxide, hexamethylene bisacetamide and trichostatin A. European Journal of Biochemistry / Febs. 271: 2379-90. PMID 15182353 DOI: 10.1111/J.1432-1033.2004.04157.X |
0.318 |
|
| 2004 |
Seow HA, Penketh PG, Belcourt MF, Tomasz M, Rockwell S, Sartorelli AC. Nuclear overexpression of NAD(P)H:quinone oxidoreductase 1 in Chinese hamster ovary cells increases the cytotoxicity of mitomycin C under aerobic and hypoxic conditions. The Journal of Biological Chemistry. 279: 31606-12. PMID 15155746 DOI: 10.1074/Jbc.M404910200 |
0.779 |
|
| 2004 |
Bordonaro M, Lazarova DL, Sartorelli AC. Pharmacological and genetic modulation of Wnt-targeted Cre-Lox-mediated gene expression in colorectal cancer cells. Nucleic Acids Research. 32: 2660-74. PMID 15141037 DOI: 10.1093/Nar/Gkh596 |
0.322 |
|
| 2004 |
Lazarova DL, Bordonaro M, Carbone R, Sartorelli AC. Linear relationship between Wnt activity levels and apoptosis in colorectal carcinoma cells exposed to butyrate. International Journal of Cancer. 110: 523-31. PMID 15122584 DOI: 10.1002/Ijc.20152 |
0.388 |
|
| 2004 |
Rice AM, Li J, Sartorelli AC. Combination of all-trans retinoic acid and lithium chloride surmounts a retinoid differentiation block induced by expression of Scl and Rbtn2 transcription factors in myeloid leukemia cells. Leukemia Research. 28: 399-403. PMID 15109540 DOI: 10.1016/J.Leukres.2003.08.011 |
0.352 |
|
| 2004 |
Lin ZP, Belcourt MF, Cory JG, Sartorelli AC. Stable suppression of the R2 subunit of ribonucleotide reductase by R2-targeted short interference RNA sensitizes p53(-/-) HCT-116 colon cancer cells to DNA-damaging agents and ribonucleotide reductase inhibitors. The Journal of Biological Chemistry. 279: 27030-8. PMID 15096505 DOI: 10.1074/Jbc.M402056200 |
0.334 |
|
| 2004 |
Cai J, Chen Y, Murphy TJ, Jones DP, Sartorelli AC. Role of caspase activation in butyrate-induced terminal differentiation of HT29 colon carcinoma cells. Archives of Biochemistry and Biophysics. 424: 119-27. PMID 15047183 DOI: 10.1016/J.Abb.2004.02.012 |
0.337 |
|
| 2004 |
Seow HA, Penketh PG, Baumann RP, Sartorelli AC. Bioactivation and resistance to mitomycin C. Methods in Enzymology. 382: 221-33. PMID 15047104 DOI: 10.1016/S0076-6879(04)82012-3 |
0.771 |
|
| 2003 |
Penketh PG, Shyam K, Baumann RP, Remack JS, Brent TP, Sartorelli AC. 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (VNP40101M): I. Direct inhibition of O6-alkylguanine-DNA alkyltransferase (AGT) by electrophilic species generated by decomposition. Cancer Chemotherapy and Pharmacology. 53: 279-87. PMID 14704831 DOI: 10.1007/S00280-003-0740-7 |
0.304 |
|
| 2003 |
Baumann RP, Shyam K, Penketh PG, Remack JS, Brent TP, Sartorelli AC. 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (VNP40101M): II. Role of O6-alkylguanine-DNA alkyltransferase in cytotoxicity. Cancer Chemotherapy and Pharmacology. 53: 288-95. PMID 14685775 DOI: 10.1007/S00280-003-0739-0 |
0.386 |
|
| 2003 |
Holtz KM, Rice AM, Sartorelli AC. Lithium chloride inactivates the 20S proteasome from WEHI-3B D+ leukemia cells. Biochemical and Biophysical Research Communications. 303: 1058-64. PMID 12684043 DOI: 10.1016/S0006-291X(03)00473-X |
0.355 |
|
| 2003 |
Holtz KM, Rockwell S, Tomasz M, Sartorelli AC. Nuclear overexpression of NADH:cytochrome b5 reductase activity increases the cytotoxicity of mitomycin C (MC) and the total number of MC-DNA adducts in Chinese hamster ovary cells. The Journal of Biological Chemistry. 278: 5029-34. PMID 12424239 DOI: 10.1074/Jbc.M209722200 |
0.439 |
|
| 2002 |
Baumann RP, Sherman DH, Sartorelli AC. Novel selection marker for mammalian cell transfection. Biotechniques. 32: 1030, 1032, 1034 pas. PMID 12019775 DOI: 10.2144/02325St03 |
0.354 |
|
| 2002 |
Bordonaro M, Lazarova DL, Augenlicht LH, Sartorelli AC. Cell type- and promoter-dependent modulation of the Wnt signaling pathway by sodium butyrate. International Journal of Cancer. 97: 42-51. PMID 11774242 DOI: 10.1002/Ijc.1577 |
0.374 |
|
| 2001 |
Baumann RP, Hodnick WF, Seow HA, Belcourt MF, Rockwell S, Sherman DH, Sartorelli AC. Reversal of mitomycin C resistance by overexpression of bioreductive enzymes in Chinese hamster ovary cells. Cancer Research. 61: 7770-6. PMID 11691791 |
0.756 |
|
| 2001 |
Rice AM, Sartorelli AC. Inhibition of 20 S and 26 S proteasome activity by lithium chloride: impact on the differentiation of leukemia cells by all-trans retinoic acid. The Journal of Biological Chemistry. 276: 42722-7. PMID 11555654 DOI: 10.1074/Jbc.M106583200 |
0.337 |
|
| 2001 |
Penketh PG, Hodnick WF, Belcourt MF, Shyam K, Sherman DH, Sartorelli AC. Inhibition of DNA cross-linking by mitomycin C by peroxidase-mediated oxidation of mitomycin C hydroquinone. The Journal of Biological Chemistry. 276: 34445-52. PMID 11457837 DOI: 10.1074/Jbc.M104263200 |
0.333 |
|
| 2001 |
Palom Y, Belcourt MF, Tang LQ, Mehta SS, Sartorelli AC, Pritsos CA, Pritsos KL, Rockwell S, Tomasz M. Bioreductive metabolism of mitomycin C in EMT6 mouse mammary tumor cells: cytotoxic and non-cytotoxic pathways, leading to different types of DNA adducts. The effect of dicumarol. Biochemical Pharmacology. 61: 1517-29. PMID 11377381 DOI: 10.1016/S0006-2952(01)00609-8 |
0.42 |
|
| 2001 |
Rappa G, Shyam K, Lorico A, Fodstad O, Sartorelli AC. Structure-activity studies of novobiocin analogs as modulators of the cytotoxicity of etoposide (VP-16). Oncology Research. 12: 113-9. PMID 11216669 DOI: 10.3727/096504001108747585 |
0.403 |
|
| 2000 |
Palom Y, Belcourt MF, Musser SM, Sartorelli AC, Rockwell S, Tomasz M. Structure of adduct X, the last unknown of the six major DNA adducts of mitomycin C formed in EMT6 mouse mammary tumor cells. Chemical Research in Toxicology. 13: 479-88. PMID 10858321 DOI: 10.1021/Tx000024J |
0.36 |
|
| 2000 |
Finch RA, Liu M, Grill SP, Rose WC, Loomis R, Vasquez KM, Cheng Y, Sartorelli AC. Triapine (3-aminopyridine-2-carboxaldehyde- thiosemicarbazone): A potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity. Biochemical Pharmacology. 59: 983-91. PMID 10692563 DOI: 10.1016/S0006-2952(99)00419-0 |
0.431 |
|
| 2000 |
Penketh PG, Shyam K, Sartorelli AC. Comparison of DNA lesions produced by tumor-inhibitory 1,2-bis(sulfonyl)hydrazines and chloroethylnitrosoureas. Biochemical Pharmacology. 59: 283-91. PMID 10609557 DOI: 10.1016/S0006-2952(99)00328-7 |
0.374 |
|
| 2000 |
Finch RA, Li J, Chou T, Sartorelli AC. Maintenance of retinoic acid receptor alpha pools by granulocyte colony-stimulating factor and lithium chloride in all-trans retinoic acid–treated WEHI-3B leukemia cells: relevance to the synergistic induction of terminal differentiation Blood. 96: 2262-2268. DOI: 10.1182/Blood.V96.6.2262.H8002262_2262_2268 |
0.343 |
|
| 1999 |
Finch RA, Liu MC, Cory AH, Cory JG, Sartorelli AC. Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): An inhibitor of ribonucleotide reductase with antineoplastic activity Advances in Enzyme Regulation. 39: 3-12. PMID 10470363 DOI: 10.1016/S0065-2571(98)00017-X |
0.429 |
|
| 1999 |
Belcourt MF, Penketh PG, Hodnick WF, Johnson DA, Sherman DH, Rockwell S, Sartorelli AC. Mitomycin resistance in mammalian cells expressing the bacterial mitomycin C resistance protein MCRA. Proceedings of the National Academy of Sciences of the United States of America. 96: 10489-94. PMID 10468636 DOI: 10.1073/Pnas.96.18.10489 |
0.369 |
|
| 1999 |
Rappa G, Finch RA, Sartorelli AC, Lorico A. New insights into the biology and pharmacology of the Multidrug Resistance Protein (MRP) from gene knockout models Biochemical Pharmacology. 58: 557-562. PMID 10413292 DOI: 10.1016/S0006-2952(99)00074-X |
0.316 |
|
| 1999 |
Li J, Finch RA, Sartorelli AC. Role of vitamin D3 receptor in the synergistic differentiation of WEHI- 3B leukemia cells by vitamin D3 and retinoic acid Experimental Cell Research. 249: 279-290. PMID 10366427 DOI: 10.1006/Excr.1999.4475 |
0.3 |
|
| 1999 |
Shyam K, Penketh PG, Shapiro M, Belcourt MF, Loomis RH, Rockwell S, Sartorelli AC. Hypoxia-selective nitrobenzyloxycarbonyl derivatives of 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazines. Journal of Medicinal Chemistry. 42: 941-6. PMID 10072691 DOI: 10.1021/Jm9805891 |
0.412 |
|
| 1998 |
Belcourt MF, Hodnick WF, Rockwell S, Sartorelli AC. Exploring the mechanistic aspects of mitomycin antibiotic bioactivation in chinese hamster ovary cells overexpressing NADPH:cytochrome C (P-450) reductase and DT-diaphorase Advances in Enzyme Regulation. 38: 111-133. PMID 9762350 DOI: 10.1016/S0065-2571(97)00009-5 |
0.398 |
|
| 1998 |
Ishiguro K, Sartorelli AC. Characterization of the domains of the erythropoietin receptor necessary for induction of cell growth and differentiation. Cytokine. 10: 564-77. PMID 9722929 DOI: 10.1006/Cyto.1998.0331 |
0.308 |
|
| 1998 |
Chen Y, Sokoloski JA, Chu E, Sartorelli AC. Regulation of the expression of enzymes involved in the replication of DNA in chemically induced monocytic/macrophagic differentiation of HL-60 leukemia cells. Leukemia Research. 22: 697-703. PMID 9680096 DOI: 10.1016/S0145-2126(98)00054-X |
0.348 |
|
| 1998 |
Chen Y, Sokoloski JA, Chu E, Sartorelli AC. Regulation of the expression of enzymes involved in the replication of DNA in chemically-induced granulocytic differentiation of HL-60 leukemia cells. Leukemia Research. 22: 687-95. PMID 9680095 DOI: 10.1016/S0145-2126(98)00053-8 |
0.379 |
|
| 1998 |
Li J, Finch RA, Xiao W, Sartorelli AC. Identification of a repressor of the differentiation of WEHI-3B D- leukemia cells Experimental Cell Research. 242: 274-284. PMID 9665825 DOI: 10.1006/Excr.1998.4106 |
0.325 |
|
| 1998 |
Sokoloski JA, Sartorelli AC. Induction of the differentiation of HL-60 promyelocytic leukemia cells by nonsteroidal anti-inflammatory agents in combination with low levels of vitamin D3. Leukemia Research. 22: 153-61. PMID 9593472 DOI: 10.1016/S0145-2126(97)00156-2 |
0.316 |
|
| 1998 |
Sokoloski JA, Narayanan R, Sartorelli AC. Enhancement by antisense oligonucleotides to NF-kappaB of the differentiation of HL-60 promyelocytic leukemia cells induced by vitamin D3. Cancer Letters. 125: 157-64. PMID 9566710 DOI: 10.1016/S0304-3835(97)00505-3 |
0.34 |
|
| 1998 |
Belcourt MF, Hodnick WF, Rockwell S, Sartorelli AC. The intracellular location of NADH:cytochrome b5 reductase modulates the cytotoxicity of the mitomycins to Chinese hamster ovary cells Journal of Biological Chemistry. 273: 8875-8881. PMID 9535868 DOI: 10.1074/Jbc.273.15.8875 |
0.38 |
|
| 1998 |
Ishiguro K, Sartorelli AC. Coinduction of Embryonic and Adult-Type Globin mRNAs by Sodium Butyrate and Trichostatin A in Two Murine Interleukin-3–Dependent Bone Marrow–Derived Cell Lines Blood. 92: 4383-4393. DOI: 10.1182/Blood.V92.11.4383.423K18_4383_4393 |
0.312 |
|
| 1997 |
Hodnick WF, Sartorelli AC. Measurement of dicumarol-sensitive NADPH: (menadione-cytochrome c) oxidoreductase activity results in an artifactual assay of DT-diaphorase in cell sonicates. Analytical Biochemistry. 252: 165-8. PMID 9324955 DOI: 10.1006/Abio.1997.2313 |
0.385 |
|
| 1997 |
Rappa G, Lorico A, Liu MC, Kruh GD, Cory AH, Cory JG, Sartorelli AC. Overexpression of the multidrug resistance genes mdr1, mdr3, and mrp in L1210 leukemia cells resistant to inhibitors of ribonucleotide reductase. Biochemical Pharmacology. 54: 649-55. PMID 9310341 DOI: 10.1016/S0006-2952(97)00210-4 |
0.356 |
|
| 1997 |
Sokoloski JA, Hodnick WF, Mayne ST, Cinquina C, Kim CS, Sartorelli AC. Induction of the differentiation of HL-60 promyelocytic leukemia cells by vitamin E and other antioxidants in combination with low levels of vitamin D3: Possible relationship to NF-κB Leukemia. 11: 1546-1553. PMID 9305611 DOI: 10.1038/Sj.Leu.2400786 |
0.302 |
|
| 1997 |
Ishiguro K, Sartorelli AC. The response of IL-3 dependent B6SUtA bone marrow cells to both erythropoietin and chemical inducers of differentiation. Cancer Letters. 110: 233-41. PMID 9018107 DOI: 10.1016/S0304-3835(96)04516-8 |
0.332 |
|
| 1997 |
Penketh PG, Shyam K, Sartorelli AC. Mechanisms of resistance to alkylating agents. Cancer Treatment and Research. 87: 65-81. PMID 8886449 DOI: 10.1007/978-1-4613-1267-3_3 |
0.355 |
|
| 1996 |
SARTORELLI AC, BIEBER AL, CHANG PK, FISCHER GA. SOME INHIBITORY PROPERTIES OF 6-N-HYDROXYLAMINOPURINE: AN ANALOG OF ADENINE AND HYPOXANTHINE. Biochemical Pharmacology. 13: 507-15. PMID 14157613 DOI: 10.1016/0006-2952(64)90171-6 |
0.405 |
|
| 1996 |
Belcourt MF, Hodnick WF, Rockwell S, Sartorelli AC. Bioactivation of mitomycin antibiotics by aerobic and hypoxic Chinese hamster ovary cells overexpressing DT-diaphorase Biochemical Pharmacology. 51: 1669-1678. PMID 8687482 DOI: 10.1016/0006-2952(96)00143-8 |
0.384 |
|
| 1996 |
Hayashi M, Tomida M, Hozumi M, King IC, Sartorelli AC. Detection of in vivo differentiation of murine WEHI-3B D+ leukemia cells transfected with the lac-Z marker gene using two-color flow cytometry. Leukemia Research. 20: 333-41. PMID 8642845 DOI: 10.1016/0145-2126(95)00141-7 |
0.346 |
|
| 1996 |
Liu MC, Lin TS, Sartorelli AC. Chemical and biological properties of cytotoxic alpha-(N)-heterocyclic carboxaldehyde thiosemicarbazones. Progress in Medicinal Chemistry. 32: 1-35. PMID 8577916 DOI: 10.1016/S0079-6468(08)70451-X |
0.377 |
|
| 1996 |
Shyam K, Penketh PG, Loomis RH, Rose WC, Sartorelli AC. Antitumor 2-(aminocarbonyl)-1,2-bis(methylsulfonyl)-1-(2-chloroethyl)- hydrazines. Journal of Medicinal Chemistry. 39: 796-801. PMID 8576923 DOI: 10.1021/Jm9505021 |
0.349 |
|
| 1996 |
Belcourt MF, Hodnick WF, Rockwell S, Sartorelli AC. Differential toxicity of mitomycin C and porfiromycin to aerobic and hypoxic Chinese hamster ovary cells overexpressing human NADPH:cytochrome c (P-450) reductase Proceedings of the National Academy of Sciences of the United States of America. 93: 456-460. PMID 8552660 DOI: 10.1073/Pnas.93.1.456 |
0.39 |
|
| 1995 |
Sharma HW, Sokoloski JA, Perez JR, Maltese JY, Sartorelli AC, Stein CA, Nichols G, Khaled Z, Telang NT, Narayanan R. Differentiation of immortal cells inhibits telomerase activity. Proceedings of the National Academy of Sciences of the United States of America. 92: 12343-6. PMID 8618897 DOI: 10.1073/Pnas.92.26.12343 |
0.418 |
|
| 1995 |
Cory JG, Cory AH, Rappa G, Lorico A, Liu MC, Lin TS, Sartorelli AC. Structure-function relationships for a new series of pyridine-2-carboxaldehyde thiosemicarbazones on ribonucleotide reductase activity and tumor cell growth in culture and in vivo. Advances in Enzyme Regulation. 35: 55-68. PMID 7572354 DOI: 10.1016/0065-2571(94)00005-N |
0.403 |
|
| 1995 |
Li J, Koay DC, Sartorelli AC. The role of DNA ploidy in the differentiation of WEHI-3B D- leukemia cells transfected with the granulocyte colony-stimulating factor receptor gene. Experimental Cell Research. 219: 579-88. PMID 7543855 DOI: 10.1006/Excr.1995.1267 |
0.331 |
|
| 1994 |
Penketh PG, Shyam K, Sartorelli AC. Studies on the mechanism of decomposition and structural factors affecting the aqueous stability of 1,2-bis(sulfonyl)-1-alkylhydrazines. Journal of Medicinal Chemistry. 37: 2912-7. PMID 8071939 DOI: 10.1021/Jm00044A012 |
0.318 |
|
| 1994 |
Cory JG, Cory AH, Rappa G, Lorico A, Liu MC, Lin TS, Sartorelli AC. Inhibitors of ribonucleotide reductase. Comparative effects of amino- and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones. Biochemical Pharmacology. 48: 335-44. PMID 8053929 DOI: 10.1016/0006-2952(94)90105-8 |
0.422 |
|
| 1993 |
Sokoloski JA, Li J, Nigam A, Sartorelli AC. Induction of the differentiation of HL-60 and WEHI-3B D+ leukemia cells by lithium chloride. Leukemia Research. 17: 403-10. PMID 8388968 DOI: 10.1016/0145-2126(93)90095-3 |
0.382 |
|
| 1993 |
Goh LB, Sokoloski JA, Sartorelli AC, Lee CW. Enhancement of pertussis-toxin-sensitive Na(+)-dependent uridine transporter activity in HL-60 granulocytes by N-formylmethionyl-leucyl-phenylalanine. The Biochemical Journal. 693-7. PMID 8379925 DOI: 10.1042/Bj2940693 |
0.328 |
|
| 1993 |
Rockwell S, Sartorelli AC, Tomasz M, Kennedy KA. Cellular pharmacology of quinone bioreductive alkylating agents. Cancer Metastasis Reviews. 12: 165-76. PMID 8375019 DOI: 10.1007/Bf00689808 |
0.419 |
|
| 1993 |
Sartorelli AC, Tomasz M, Rockwell S. Studies on the mechanism of the cytotoxic action of the mitomycin antibiotics in hypoxic and oxygenated EMT6 cells. Advances in Enzyme Regulation. 33: 3-17. PMID 8356915 DOI: 10.1016/0065-2571(93)90005-X |
0.458 |
|
| 1993 |
Rockwell S, Hughes CS, Keyes SR, Sartorelli AC, Kennedy KA. Porfiromycin as an adjunct to radiotherapy in young and old mice. Experimental Gerontology. 28: 281-93. PMID 8344398 DOI: 10.1016/0531-5565(93)90035-C |
0.318 |
|
| 1993 |
Moore KG, Donadio AC, Sartorelli AC. Determination of type I transglutaminase in differentiating normal and neoplastic human keratinocytes by an in situ radioimmunoassay. Biochemical and Biophysical Research Communications. 192: 381-5. PMID 8097910 DOI: 10.1006/Bbrc.1993.1426 |
0.365 |
|
| 1993 |
Li J, Koay DC, Xiao H, Sartorelli AC. Regulation of the differentiation of WEHI-3B D+ leukemia cells by granulocyte colony-stimulating factor receptor. The Journal of Cell Biology. 120: 1481-9. PMID 7680656 DOI: 10.1083/Jcb.120.6.1481 |
0.314 |
|
| 1993 |
Lorico A, Rappa G, Sartorelli AC. Novobiocin-induced accumulation of etoposide (VP-16) in WEHI-3B D+ leukemia cells. International Journal of Cancer. 52: 903-9. PMID 1334054 DOI: 10.1002/Ijc.2910520613 |
0.373 |
|
| 1992 |
DiGiovanna MP, Sartorelli AC. Differentiation stage specificity of tyrosine phosphorylation in response to granulocyte macrophage colony stimulating factor (GM-CSF). Cancer Letters. 63: 15-22. PMID 1555204 DOI: 10.1016/0304-3835(92)90084-9 |
0.32 |
|
| 1992 |
Ishiguro K, Ho PT, Sartorelli AC. Characterization of the defect in a variant of HL-60 promyelocytic leukemia cells with reduced transferrin receptor expression. Somatic Cell and Molecular Genetics. 18: 45-63. PMID 1546369 DOI: 10.1007/Bf01233448 |
0.369 |
|
| 1992 |
Liu MC, Lin TS, Sartorelli AC. Synthesis and antitumor activity of amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone. Journal of Medicinal Chemistry. 35: 3672-7. PMID 1433178 DOI: 10.1021/Jm00098A012 |
0.306 |
|
| 1992 |
Wang Y, Liu MC, Lin TS, Sartorelli AC. Synthesis and antitumor activity of 3- and 5-hydroxy-4-methylpyridine-2-carboxaldehyde thiosemicarbazones. Journal of Medicinal Chemistry. 35: 3667-71. PMID 1433177 DOI: 10.1021/Jm00098A011 |
0.32 |
|
| 1992 |
Leung MF, Sartorelli AC. The effects of microtubule disrupting drugs on the differentiation of HL-60 leukemia cells. Leukemia Research. 16: 929-35. PMID 1405722 DOI: 10.1016/0145-2126(92)90038-9 |
0.317 |
|
| 1992 |
Li J, Sartorelli AC. Synergistic induction of the differentiation of WEHI-3B D+ myelomonocytic leukemia cells by retinoic acid and granulocyte colony-stimulating factor. Leukemia Research. 16: 571-6. PMID 1378916 DOI: 10.1016/0145-2126(92)90004-Q |
0.318 |
|
| 1992 |
Rappa G, Lorico A, Sartorelli AC. Potentiation by novobiocin of the cytotoxic activity of etoposide (VP-16) and teniposide (VM-26). International Journal of Cancer. 51: 780-7. PMID 1377186 DOI: 10.1002/Ijc.2910510519 |
0.419 |
|
| 1992 |
Moore KG, Sartorelli AC. Annexin I and involucrin are cross-linked by particulate transglutaminase into the cornified cell envelope of squamous cell carcinoma Y1. Experimental Cell Research. 200: 186-95. PMID 1348694 DOI: 10.1016/S0014-4827(05)80087-4 |
0.359 |
|
| 1991 |
Rockwell S, Keyes SR, Loomis R, Kelley M, Vyas DM, Wong H, Doyle TW, Sartorelli AC. Activity of C-7 substituted cyclic acetal derivatives of mitomycin C and porfiromycin against hypoxic and oxygenated EMT6 carcinoma cells in vitro and in vivo. Cancer Communications. 3: 191-8. PMID 2049227 DOI: 10.3727/095535491820873290 |
0.406 |
|
| 1991 |
Sokoloski JA, Sartorelli AC. Expression of memory to the terminal differentiation inducing activity of tiazofurin in HL-60 leukemia cells. Leukemia Research. 15: 395-402. PMID 2046392 DOI: 10.1016/0145-2126(91)90016-M |
0.346 |
|
| 1991 |
Sokoloski JA, Beardsley GP, Sartorelli AC. Induction of HL-60 leukemia cell differentiation by tetrahydrofolate inhibitors of de novo purine nucleotide biosynthesis. Cancer Chemotherapy and Pharmacology. 28: 39-44. PMID 2040032 DOI: 10.1007/Bf00684954 |
0.411 |
|
| 1991 |
Keyes SR, Rockwell S, Kennedy KA, Sartorelli AC. Distribution of porfiromycin in EMT6 solid tumors and normal tissues of BALB/c mice. Journal of the National Cancer Institute. 83: 632-7. PMID 2023281 DOI: 10.1093/Jnci/83.9.632 |
0.313 |
|
| 1991 |
Lee CW, Sokoloski JA, Sartorelli AC, Handschumacher RE. Induction of the differentiation of HL-60 cells by phorbol 12-myristate 13-acetate activates a Na+-dependent uridine-transport system. Involvement of protein kinase C Biochemical Journal. 274: 85-90. PMID 2001255 DOI: 10.1042/Bj2740085 |
0.336 |
|
| 1991 |
Sokoloski JA, Lee CW, Handschumacher RE, Nigam A, Sartorelli AC. Effects of uridine on the growth and differentiation of HL-60 leukemia cells Leukemia Research. 15: 1051-1058. PMID 1961008 DOI: 10.1016/0145-2126(91)90111-6 |
0.38 |
|
| 1991 |
Saari WS, Schwering JE, Lyle PA, Engelhardt EL, Sartorelli AC, Rockwell S. Synthesis and evaluation of some nitrobenzenesulfonamides containing nitroisopropyl and (ureidooxy)methyl groups as novel hypoxic cell selective cytotoxic agents. Journal of Medicinal Chemistry. 34: 3132-8. PMID 1920362 DOI: 10.1021/Jm00114A024 |
0.403 |
|
| 1991 |
Penketh PG, Divo AA, Shyam K, Patton CL, Sartorelli AC. The effects of the methylating agent 1,2-bis(methylsulfonyl)-1-methylhydrazine on morphology, DNA content and mitochondrial function of Trypanosoma brucei subspecies. The Journal of Protozoology. 38: 172-7. PMID 1880758 DOI: 10.1111/J.1550-7408.1991.Tb04425.X |
0.376 |
|
| 1991 |
Ho PT, Ishiguro K, Wickstrom E, Sartorelli AC. Non-sequence-specific inhibition of transferrin receptor expression in HL-60 leukemia cells by phosphorothioate oligodeoxynucleotides Antisense Research and Development. 1: 329-342. PMID 1821654 DOI: 10.1089/Ard.1991.1.329 |
0.384 |
|
| 1991 |
Keyes SR, Loomis R, DiGiovanna MP, Pritsos CA, Rockwell S, Sartorelli AC. Cytotoxicity and DNA crosslinks produced by mitomycin analogs in aerobic and hypoxic EMT6 cells. Cancer Communications. 3: 351-6. PMID 1760250 DOI: 10.3727/095535491820873812 |
0.407 |
|
| 1991 |
Sokoloski JA, Sartorelli AC, Handschumacher RE, Lee CW. Inhibition by pertussis toxin of the activation of Na+-dependent uridine transport in dimethyl-sulphoxide-induced HL-60 leukaemia cells Biochemical Journal. 280: 515-519. PMID 1747127 DOI: 10.1042/Bj2800515 |
0.334 |
|
| 1991 |
Tomasz M, Hughes CS, Chowdary D, Keyes SR, Lipman R, Sartorelli AC, Rockwell S. Isolation, identification, and assay of [3H]-porfiromycin adducts of EMT6 mouse mammary tumor cell DNA: effects of hypoxia and dicumarol on adduct patterns. Cancer Communications. 3: 213-23. PMID 1714285 DOI: 10.3727/095535491820873227 |
0.41 |
|
| 1991 |
Buddhu S, Penketh PG, Divo AA, Shyam K, Patton CL, Sartorelli AC. Enhancement of the trypanocidal activity of methyltriazenes in an animal model by the addition of an amidino group. Acta Tropica. 49: 69-72. PMID 1678578 DOI: 10.1016/0001-706X(91)90032-F |
0.35 |
|
| 1990 |
Penketh PG, Shyam K, Divo AA, Patton CL, Sartorelli AC. Methylating agents as trypanocides. Journal of Medicinal Chemistry. 33: 730-2. PMID 2299638 DOI: 10.1021/Jm00164A041 |
0.349 |
|
| 1990 |
Violette SM, King I, Browning JL, Pepinsky RB, Wallner BP, Sartorelli AC. Role of lipocortin I in the glucocorticoid induction of the terminal differentiation of a human squamous carcinoma Journal of Cellular Physiology. 142: 70-77. PMID 2137129 DOI: 10.1002/Jcp.1041420110 |
0.353 |
|
| 1989 |
Violette SM, King I, Sartorelli AC. Antagonistic effects of retinoic acid and hydrocortisone on terminal differentiation of human squamous carcinoma cells. The Journal of Investigative Dermatology. 93: 165-8. PMID 2746001 DOI: 10.1111/1523-1747.Ep12277393 |
0.366 |
|
| 1989 |
Sokoloski JA, Blair OC, Carbone R, Sartorelli AC. Induction of the differentiation of synchronized HL-60 leukemia cells by tiazofurin. Experimental Cell Research. 182: 234-41. PMID 2714402 DOI: 10.1016/0014-4827(89)90294-2 |
0.364 |
|
| 1989 |
Violette SM, King I, Sartorelli AC. Induction of the terminal differentiation of a human squamous cell carcinoma by steroids with glucocorticoid activity. Journal of Steroid Biochemistry. 33: 1001-5. PMID 2481155 DOI: 10.1016/0022-4731(89)90252-5 |
0.391 |
|
| 1989 |
Rockwell S, Keyes SR, Sartorelli AC. Modulation of the antineoplastic efficacy of mitomycin C by dicoumarol in vivo. Cancer Chemotherapy and Pharmacology. 24: 349-53. PMID 2477164 DOI: 10.1007/Bf00257440 |
0.355 |
|
| 1988 |
Rockwell S, Keyes SR, Sartorelli AC. Preclinical studies of porfiromycin as an adjunct to radiotherapy. Radiation Research. 116: 100-13. PMID 3186923 DOI: 10.2307/3577481 |
0.388 |
|
| 1988 |
Divo AA, Sartorelli AC, Patton CL, Bia FJ. Activity of fluoroquinolone antibiotics against Plasmodium falciparum in vitro. Antimicrobial Agents and Chemotherapy. 32: 1182-6. PMID 2847647 DOI: 10.1128/Aac.32.8.1182 |
0.327 |
|
| 1988 |
Reiss M, Dibble CL, Sartorelli AC. Down-regulation of glucocorticoid binding sites by retinoic acid in squamous carcinoma cells resistant to the induction of keratinization by hydrocortisone. The Journal of Investigative Dermatology. 91: 344-8. PMID 2459262 DOI: 10.1111/1523-1747.Ep12475690 |
0.349 |
|
| 1988 |
Lin T, Cai G, Sartorelli AC. Synthesis of Bis(Aziridinyl) Phosphinic Amide Derivatives of Thymidine as Potential Anticancer Agents Nucleosides and Nucleotides. 7: 403-408. DOI: 10.1080/07328318808068720 |
0.352 |
|
| 1987 |
Sokoloski JA, Jastreboff MM, Bertino JR, Sartorelli AC, Narayanan R. Introduction of deoxyribonucleoside triphosphates into intact cells by electroporation. Analytical Biochemistry. 158: 272-7. PMID 3812972 DOI: 10.1016/0003-2697(86)90549-X |
0.384 |
|
| 1987 |
Shyam K, Furubayashi R, Hrubiec RT, Cosby LA, Sartorelli AC. 1,2-bis(arylsulfonyl)hydrazines. 2. The influence of arylsulfonyl and aralkylsulfonyl substituents on antitumor and alkylating activity. Journal of Medicinal Chemistry. 29: 1323-5. PMID 3806585 DOI: 10.1021/Jm00157A041 |
0.357 |
|
| 1987 |
Shyam K, Hrubiec RT, Furubayashi R, Cosby LA, Sartorelli AC. 1,2-Bis(sulfonyl)hydrazines. 3. Effects of structural modification on antineoplastic activity. Journal of Medicinal Chemistry. 30: 2157-61. PMID 3669023 DOI: 10.1021/Jm00394A040 |
0.365 |
|
| 1987 |
Sokoloski JA, Sartorelli AC. Inhibition of mannose incorporation into glycoproteins and dolichol-linked intermediates of Sarcoma 180 cells by 6-methylmercaptopurine ribonucleoside. International Journal of Cancer. 39: 764-8. PMID 3583454 DOI: 10.1002/Ijc.2910390618 |
0.427 |
|
| 1987 |
Sartorelli AC, Ishiguro K, King CL, Morin MJ, Reiss M. Mechanisms involved in the induction of malignant cell differentiation. Advances in Enzyme Regulation. 25: 507-29. PMID 3544708 DOI: 10.1016/0065-2571(86)90031-2 |
0.388 |
|
| 1987 |
Keyes SR, Hickman JA, Sartorelli AC. The effects of adriamycin on intracellular calcium concentrations of L1210 murine leukemia cells. European Journal of Cancer & Clinical Oncology. 23: 295-302. PMID 2439346 DOI: 10.1016/0277-5379(87)90073-3 |
0.301 |
|
| 1986 |
Lin TS, Wang L, Antonini I, Cosby LA, Shiba DA, Kirkpatrick DL, Sartorelli AC. (o- and p-Nitrobenzyloxycarbonyl)-5-fluorouracil derivatives as potential conjugated bioreductive alkylating agents. Journal of Medicinal Chemistry. 29: 84-9. PMID 3941417 DOI: 10.1002/Chin.198620222 |
0.357 |
|
| 1986 |
Hrubiec RT, Shyam K, Cosby LA, Sartorelli AC. Synthesis and evaluation of 1-(arylsulfonyl)-2-[(methoxycarbonyl)sulfenyl]-1-methylhydrazines++ + as antineoplastic agents. Journal of Medicinal Chemistry. 29: 1777-9. PMID 3746822 DOI: 10.1021/Jm00159A036 |
0.346 |
|
| 1986 |
Reiss M, Maniglia CA, Sartorelli AC. Modulation of cell shedding and glycosaminoglycan synthesis of human malignant keratinocytes by all-trans-retinoic acid and hydrocortisone in vitro. The Journal of Investigative Dermatology. 86: 683-8. PMID 3711682 DOI: 10.1111/1523-1747.Ep12276266 |
0.3 |
|
| 1986 |
King IC, Sartorelli AC. The relationship between epidermal growth factor receptors and the terminal differentiation of A431 carcinoma cells. Biochemical and Biophysical Research Communications. 140: 837-43. PMID 3490853 DOI: 10.1016/0006-291X(86)90710-2 |
0.319 |
|
| 1986 |
King I, Mella SL, Sartorelli AC. A sensitive method to quantify the terminal differentiation of cultured epidermal cells. Experimental Cell Research. 167: 252-6. PMID 3489631 DOI: 10.1016/0014-4827(86)90221-1 |
0.346 |
|
| 1986 |
Maniglia CA, Loulakis PP, Sartorelli AC. Interference with tumor cell-induced degradation of endothelial matrix on the antimetastatic action of nafazatrom. Journal of the National Cancer Institute. 76: 739-44. PMID 3457206 DOI: 10.1093/Jnci/76.4.739 |
0.371 |
|
| 1986 |
Blair OC, Carbone R, Sartorelli AC. Differentiation of HL-60 promyelocytic leukemia cells: simultaneous determination of phagocytic activity and cell cycle distribution by flow cytometry. Cytometry. 7: 171-7. PMID 3456296 DOI: 10.1002/Cyto.990070208 |
0.344 |
|
| 1986 |
Frank DA, Sartorelli AC. Regulation of protein phosphotyrosine content by changes in tyrosine kinase and protein phosphotyrosine phosphatase activities during induced granulocytic and monocytic differentiation of HL-60 leukemia cells. Biochemical and Biophysical Research Communications. 140: 440-7. PMID 2430565 DOI: 10.1016/0006-291X(86)91110-1 |
0.316 |
|
| 1986 |
SHYAM K, FURUBAYASHI R, HRUBIEC RT, COSBY LA, SARTORELLI AC. ChemInform Abstract: 1,2-Bis(arylsulfonyl)hydrazines. Part 2. The Influence of Arylsulfonyl and Aralkylsulfonyl Substituents on Antitumor and Alkylating Activity. Chemischer Informationsdienst. 17. DOI: 10.1002/Chin.198648171 |
0.304 |
|
| 1985 |
Hadfield AF, Sartorelli AC. The pharmacology of prodrugs of 5-fluorouracil and 1-beta-D-arabinofuranosylcytosine. Advances in Pharmacology and Chemotherapy. 20: 21-67. PMID 6085531 DOI: 10.1016/S1054-3589(08)60264-1 |
0.301 |
|
| 1985 |
Keyes SR, Heimbrook DC, Fracasso PM, Rockwell S, Sligar SG, Sartorelli AC. Chemotherapeutic attack of hypoxic tumor cells by the bioreductive alkylating agent mitomycin C. Advances in Enzyme Regulation. 23: 291-307. PMID 3934922 DOI: 10.1016/0065-2571(85)90053-6 |
0.415 |
|
| 1985 |
Sartorelli AC. The 1985 Walter Hubert lecture. Malignant cell differentiation as a potential therapeutic approach. British Journal of Cancer. 52: 293-302. PMID 3899154 DOI: 10.1038/bjc.1985.193 |
0.303 |
|
| 1985 |
Lin TS, Cheng JC, Ishiguro K, Sartorelli AC. Purine and 8-substituted purine arabinofuranosyl and ribofuranosyl nucleoside derivatives as potential inducers of the differentiation of the friend erythroleukemia Journal of Medicinal Chemistry. 28: 1481-1485. PMID 3862866 DOI: 10.1021/Jm00148A018 |
0.327 |
|
| 1985 |
Lin TS, Cheng JC, Ishiguro K, Sartorelli AC. 8-substituted guanosine and 2′-deoxyguanosine derivatives as potential inducers of the differentiation of friend erythroleukemia cells Journal of Medicinal Chemistry. 28: 1194-1198. PMID 3861870 DOI: 10.1002/Chin.198551320 |
0.402 |
|
| 1985 |
Blair OC, Carbone R, Sartorelli AC. Differentiation of HL-60 promyelocytic leukemia cells monitored by flow cytometric measurement of nitro blue tetrazolium (NBT) reduction. Cytometry. 6: 54-61. PMID 3855396 DOI: 10.1002/Cyto.990060110 |
0.348 |
|
| 1985 |
Reiss M, Pitman SW, Sartorelli AC. Modulation of the terminal differentiation of human squamous carcinoma cells in vitro by all-trans-retinoic acid. Journal of the National Cancer Institute. 74: 1015-1023. DOI: 10.1093/Jnci/74.5.1015 |
0.357 |
|
| 1984 |
Lin TS, Antonini I, Cosby LA, Sartorelli AC. 2,3-Dimethyl-1,4-naphthoquinone derivatives as bioreductive alkylating agents with cross-linking potential. Journal of Medicinal Chemistry. 27: 813-5. PMID 6737425 DOI: 10.1002/Chin.198444147 |
0.361 |
|
| 1984 |
Ishiguro K, Schwartz EL, Sartorelli AC. Characterization of the metabolic forms of 6-thioguanine responsible for cytotoxicity and induction of differentiation of HL-60 acute promyelocytic leukemia cells. Journal of Cellular Physiology. 121: 383-90. PMID 6593322 DOI: 10.1002/Jcp.1041210216 |
0.431 |
|
| 1984 |
Canellakis ZN, Bondy PK, May JA, Myers-Robfogel MK, Sartorelli AC. Identification of a glycosidase activity with apparent specificity for 2-deoxy-D-glucose in glycosidic linkage. European Journal of Biochemistry / Febs. 143: 159-63. PMID 6468386 DOI: 10.1111/J.1432-1033.1984.Tb08354.X |
0.314 |
|
| 1984 |
Blair OC, Sartorelli AC. Incorporation of 35S-sulfate and 3H-glucosamine into heparan and chondroitin sulfates during the cell cycle of B16-F10 cells. Cytometry. 5: 281-8. PMID 6234152 DOI: 10.1002/Cyto.990050311 |
0.314 |
|
| 1983 |
Blair OC, Burger DE, Sartorelli AC. Analysis of glycosaminoglycans of flow sorted cells: incorporation of [35S]sulfate and [3H]glucosamine into glycosaminoglycans of B16-F10 cells during the cell cycle. Cytometry. 3: 166-71. PMID 7172938 DOI: 10.1002/Cyto.990030305 |
0.304 |
|
| 1983 |
Wang L, Maniglia CA, Mella SL, Sartorelli AC. N-(substituted-phenyl)-D-glycopyranosylamines and their O-acetyl derivatives as potential modifiers of the formation of glycosaminoglycans. Journal of Medicinal Chemistry. 26: 1323-6. PMID 6887209 DOI: 10.1002/Chin.198406342 |
0.347 |
|
| 1983 |
Schwartz EL, Hadfield AF, Brown AE, Sartorelli AC. Modification of sialic acid metabolism of murine erythroleukemia cells by analogs of N-acetylmannosamine. Biochimica Et Biophysica Acta. 762: 489-97. PMID 6871252 DOI: 10.1016/0167-4889(83)90051-4 |
0.363 |
|
| 1983 |
Wang L, Maniglia CA, Mella SL, Sartorelli AC. Synthesis of N-(Substituted-phenyl)-D-xylopyranosylamines as potential modifiers of the formation of glycosaminoglycans. Journal of Medicinal Chemistry. 26: 629-32. PMID 6842504 DOI: 10.1002/Chin.198338348 |
0.391 |
|
| 1983 |
Siegfried JM, Tritton TR, Sartorelli AC. Comparison of anthracycline concentrations in S180 cell lines of varying sensitivity. European Journal of Cancer & Clinical Oncology. 19: 1133-41. PMID 6684559 DOI: 10.1016/0277-5379(83)90039-1 |
0.343 |
|
| 1983 |
Hadfield AF, Mella SL, Sartorelli AC. N-acetyl-D-mannosamine analogues as potential inhibitors of sialic acid biosynthesis. Journal of Pharmaceutical Sciences. 72: 748-51. PMID 6577183 DOI: 10.1002/Jps.2600720709 |
0.302 |
|
| 1983 |
Luikart SD, Maniglia CA, Sartorelli AC. Influence of collagen substrata on glycosaminoglycan production by B16 melanoma cells. Proceedings of the National Academy of Sciences of the United States of America. 80: 3738-42. PMID 6574512 DOI: 10.1073/Pnas.80.12.3738 |
0.319 |
|
| 1983 |
Schwartz EL, Ishiguro K, Sartorelli AC. Induction of leukemia cell differentiation by chemotherapeutic agents. Advances in Enzyme Regulation. 21: 3-20. PMID 6400065 DOI: 10.1016/0065-2571(83)90005-5 |
0.431 |
|
| 1982 |
Murphree SA, Tritton TR, Smith PL, Sartorelli AC. Adriamycin-induced changes in the surface membrane of sarcoma 180 ascites cells. Biochimica Et Biophysica Acta. 649: 317-24. PMID 7317402 DOI: 10.1016/0005-2736(81)90421-1 |
0.32 |
|
| 1982 |
Antonini I, Lin TS, Cosby LA, Dai YR, Sartorelli AC. 2- and 6-methyl-1,4-naphthoquinone derivatives and potential bioreductive alkylating agents. Journal of Medicinal Chemistry. 25: 730-5. PMID 7097727 DOI: 10.1002/Chin.198246156 |
0.374 |
|
| 1982 |
Rittmann LS, Jelsema CL, Schwartz EL, Tsiftsoglou AS, Sartorelli AC. Lipid composition of Friend leukemia cells following induction of erythroid differentiation by dimethyl sulfoxide. Journal of Cellular Physiology. 110: 50-5. PMID 7068766 DOI: 10.1002/Jcp.1041100109 |
0.353 |
|
| 1982 |
Brown AE, Schwartz EL, Dreyer RN, Sartorelli AC. Synthesis of sialoglycoconjugates during dimethylsulfoxide-induced erythrodifferentiation of friend leukemia cells. Biochimica Et Biophysica Acta. 714: 217-25. PMID 7055615 DOI: 10.1016/0304-4165(82)90327-0 |
0.342 |
|
| 1982 |
Sartorelli AC. Changes in surface architecture during murine erythroleukemia cell differentiation as detected by lectin binding and agglutination. Biochimica Et Biophysica Acta. 649: 105-12. PMID 6946835 DOI: 10.1016/0005-2736(81)90014-6 |
0.363 |
|
| 1982 |
Kennedy KA, Sligar SG, Polomski L, Sartorelli AC. Metabolic activation of mitomycin C by liver microsomes and nuclei Biochemical Pharmacology. 31: 2011-2016. PMID 6810899 DOI: 10.1016/0006-2952(82)90414-2 |
0.367 |
|
| 1982 |
Rockwell S, Kennedy KA, Sartorelli AC. Mitomycin-C as a prototype bioreductive alkylating agent: In vitro studies of metabolism and cytotoxicity International Journal of Radiation Oncology, Biology, Physics. 8: 753-755. PMID 6809706 DOI: 10.1016/0360-3016(82)90728-3 |
0.396 |
|
| 1982 |
Lee MH, Lazo JS, Li CD, Hadfield AF, Maniglia CA, Sartorelli AC. Solubilization of murine melanoma xylosyltransferase and galactosyltransferase activities and their inactivation by dialdehyde nucleosides. Chemico-Biological Interactions. 41: 141-53. PMID 6809344 DOI: 10.1016/0009-2797(82)90085-0 |
0.344 |
|
| 1982 |
Allaudeen HS, Kozarich JW, Sartorelli AC. Comparative effects of the 5'-triphosphates of 9-beta-(2'-azido-2'-deoxy-D-arabinofuranosyl)adenine and 9-beta-D-arabinofuranosyladenine on DNA polymerases from L1210 leukemia cells. Nucleic Acids Research. 10: 1379-87. PMID 6175955 DOI: 10.1093/Nar/10.4.1379 |
0.345 |
|
| 1982 |
Lee SH, Sartorelli AC. Biochemical mechanism of resistance of cultured sarcoma 180 cells to 6-thioguanine. Biochemical Pharmacology. 30: 3109-14. PMID 6175317 DOI: 10.1016/0006-2952(81)90501-3 |
0.389 |
|
| 1981 |
Tsiftsoglou AS, Sartorelli AC. Relationship between cellular replication and erythroid differentiation of murine leukemia cells. Biochimica Et Biophysica Acta. 653: 226-35. PMID 7225397 DOI: 10.1016/0005-2787(81)90158-1 |
0.423 |
|
| 1981 |
Lee SH, Thomas LK, Unger FM, Christian R, Sartorelli AC. Comparative antineoplastic activity against P388 leukemia of 9-beta-D-arabinofuranosyladenine (araA) and 9-beta-(2'-azido-2'-deoxy-D-arabinofuranosyl) adenine (arazide). International Journal of Cancer. 27: 703-8. PMID 6974703 DOI: 10.1002/Ijc.2910270518 |
0.376 |
|
| 1981 |
Li C, Schwartz EL, Mella SL, Rittmann LS, Sartorelli AC. Induction of differentiation of leukemia cells in vitro by N-substituted amides, lactams, and 2-pyridones. Journal of Medicinal Chemistry. 24: 1092-4. PMID 6945436 DOI: 10.1002/Chin.198205231 |
0.352 |
|
| 1981 |
Maniglia CA, Sartorelli AC. Retinoic acid-induced alterations of glycosaminoglycan synthesis and deposition in B16F10 melanoma cells. Annals of the New York Academy of Sciences. 359: 322-30. PMID 6942678 DOI: 10.1111/J.1749-6632.1981.Tb12757.X |
0.314 |
|
| 1981 |
Tsiftsoglou AS, Bhargava KK, Rittmann LS, Sartorelli AC. Distribution of the inducer of differentiation bis-acetyl-diaminopentane in murine erythroleukemia cells. Journal of Cellular Physiology. 106: 419-24. PMID 6938518 DOI: 10.1002/Jcp.1041060311 |
0.36 |
|
| 1981 |
Li C, Mella SL, Sartorelli AC. Cyclic urea and thiourea derivatives as inducers of murine erythroleukemia differentiation. Journal of Medicinal Chemistry. 24: 1089-92. PMID 6793727 DOI: 10.1002/Chin.198205213 |
0.347 |
|
| 1980 |
Loh W, Cosby LA, Sartorelli AC. Synthesis and antineoplastic activity of phenyl-substituted benzenesulfonylhydrazones of 2-pyridinecarboxaldehyde 1-oxide Journal of Medicinal Chemistry. 23: 631-634. PMID 7392030 DOI: 10.1021/Jm00180A010 |
0.311 |
|
| 1980 |
Teicher BA, Sartorelli AC. Nitrobenzyl halides and carbamates as prototype bioreductive alkylating agents. Journal of Medicinal Chemistry. 23: 955-60. PMID 7190617 DOI: 10.1002/Chin.198105193 |
0.413 |
|
| 1980 |
Kennedy KA, Teicher BA, Rockwell S, Sartorelli AC. The hypoxic tumor cell: A target for selective cancer chemotherapy Biochemical Pharmacology. 29: 1-8. PMID 6987986 DOI: 10.1016/0006-2952(80)90235-X |
0.315 |
|
| 1980 |
Papac RJ, Brown AE, Schwartz EL, Sartorelli AC. Differentiation of human promyelocytic leukemia cells in vitro by 6-thioguanine. Cancer Letters. 10: 33-8. PMID 6939481 DOI: 10.1016/0304-3835(80)90062-2 |
0.401 |
|
| 1980 |
Lee SH, Shansky CW, Sartorelli AC. Evidence for the external location of alkaline phosphatase activity on the surface of Sarcoma 180 cells resistant to 6-thioguanine. Biochemical Pharmacology. 29: 1859-61. PMID 6250545 DOI: 10.1016/0006-2952(80)90153-7 |
0.324 |
|
| 1979 |
May JA, Sartorelli AC. Synthesis and biological activity of potential antimetabolites of L-fucose. Journal of Medicinal Chemistry. 22: 971-6. PMID 573800 DOI: 10.1002/Chin.198016295 |
0.311 |
|
| 1979 |
Brown AE, Case KR, Bosmann HB, Sartorelli AC. Cell surface charge alterations occurring during dimethylsulfoxide-induced erythrodifferentiation of Friend leukemia cells Biochemical and Biophysical Research Communications. 86: 1281-1287. PMID 571278 DOI: 10.1016/0006-291X(79)90255-9 |
0.334 |
|
| 1979 |
Li C, Lee MH, Sartorelli AC. Synthesis and biological evaluation of tetramisole analogues as inhibitors of alkaline phosphatase of the 6-thiopurine-resistant tumor sarcoma 180/TG. Journal of Medicinal Chemistry. 22: 1030-3. PMID 490546 DOI: 10.1002/Chin.198005237 |
0.357 |
|
| 1979 |
Hadfield AF, Sartorelli AC. The synthesis of some 4-substituted derivatives of 1,2,3-tri-O-acetyl-6-deoxy-L-glucopyranose having cytotoxic activity. Carbohydrate Research. 72: 235-42. PMID 476719 DOI: 10.1016/S0008-6215(00)83942-7 |
0.309 |
|
| 1979 |
Myers-Robfogel MW, Canellakis ZN, Bono VH, Dion RL, Cunningham LS, Sartorelli AC. Surface alterations of P388 leukemia cells by 2-deoxy-D-glucose. Biochemical Pharmacology. 28: 1953-7. PMID 454466 DOI: 10.1016/0006-2952(79)90650-6 |
0.33 |
|
| 1979 |
Lazo JS, Shansky CW, Sartorelli AC. Reduction in cell surface concanavalin A binding and mannose incorporation into glycoproteins of sarcoma 180 by 6-thioguanine. Biochemical Pharmacology. 28: 583-8. PMID 444245 DOI: 10.1016/0006-2952(79)90139-4 |
0.363 |
|
| 1979 |
Li C, Rittmann LS, Tsiftsoglou AS, Bhargava KK, Sartorelli AC. Pyridine derivatives as potent inducers of erythroid differentiation in Friend leukemia cells. Journal of Medicinal Chemistry. 21: 874-7. PMID 281531 DOI: 10.1002/Chin.197908173 |
0.364 |
|
| 1979 |
Hadfield AF, Cunningham L, Sartorelli AC. The synthesis and cytotoxic activity of 1,3,4-tri-O-acetyl-2,6-dideoxy-L-arabino- and -L-lyxo-hexopyranose Carbohydrate Research. 72: 93-104. DOI: 10.1016/S0008-6215(00)83926-9 |
0.311 |
|
| 1978 |
Agrawal KC, Sartorelli AC. Relationship between structure and antineoplastic activity of arylsulfonylhydrazones of 2-formylpyridine N-oxide Journal of Medicinal Chemistry. 21: 218-221. PMID 621718 DOI: 10.1021/Jm00200A015 |
0.338 |
|
| 1978 |
Agrawal KC, Sartorelli AC. The chemistry and biological activity of alpha -(N)-heterocyclic carboxaldehyde thiosemicarbazones Progress in Medicinal Chemistry. 15: 321-356. PMID 400614 DOI: 10.1016/S0079-6468(08)70259-5 |
0.402 |
|
| 1977 |
Bhargava KK, Lee MH, Huang Y, Cunningham LS, Agrawal KC, Sartorelli AC. Tetramisole analogues as inhibitors of alkaline phosphatase, an enzyme involved in the resistance of neoplastic cells to 6-thiopurines. Journal of Medicinal Chemistry. 20: 563-6. PMID 557560 DOI: 10.1002/Chin.197735211 |
0.344 |
|
| 1977 |
Lemke TL, Shek TW, Cates LA, Smith LK, Cosby LA, Sartorelli AC. Synthesis of 5,6-dihydro-8(7H)-quinolinone thiosemicarbazones as potential antitumor agents. Journal of Medicinal Chemistry. 20: 1351-1354. PMID 333114 DOI: 10.1021/Jm00220A026 |
0.339 |
|
| 1976 |
Agrawal KC, Clayman S, Sartorelli AC. Synthesis of site-directed chelating agents II: 2-formyl-3-hydroxy-4,5-bis (hydroxymethyl)pyridine thiosemicarbazone. Journal of Pharmaceutical Sciences. 65: 297-300. PMID 1255468 DOI: 10.1002/Chin.197623206 |
0.428 |
|
| 1976 |
Sartorelli AC, Agrawal KC, Tsiftsoglou AS, Moore EC. Characterization of the biochemical mechanism of action of alpha-(N)-heterocyclic carboxaldehyde thiosemicarbazones. Advances in Enzyme Regulation. 15: 117-39. PMID 1030181 DOI: 10.1016/0065-2571(77)90012-7 |
0.38 |
|
| 1976 |
Lin AJ, Sartorelli AC. Potential bioreductive alkylating agents. 7. Antitumor effects of phenyl-substituted 2-chloromethyl-3-phenyl-1,4-naphthoquinones Journal of Medicinal Chemistry. 19: 1336-1338. PMID 1003413 DOI: 10.1002/Chin.197710195 |
0.365 |
|
| 1976 |
Agrawal KC, Mooney PD, Sartorelli AC. Potential antitumor agents. 13. 4-Methyl-5-amino-1-formylisoquinoline thiosemicarbazone Journal of Medicinal Chemistry. 19: 970-972. PMID 940117 DOI: 10.1002/Chin.197645282 |
0.375 |
|
| 1976 |
Sartorelli AC, Shansky CW, Rosman M. Biochemical approaches to the combination chemotherapy of colon cancer. Cancer. 36: 2445-8. PMID 764962 DOI: 10.1002/1097-0142(197512)36:6<2445::Aid-Cncr2820360628>3.0.Co;2-A |
0.34 |
|
| 1976 |
Sartorelli AC, Agrawal KC, Booth BA, Pittman J, Bartholomew DG. Antineoplastic and biochemical properties of arylsulfonylhydrazones of 2-formylpyridine N-oxide. Journal of Medicinal Chemistry. 19: 830-3. PMID 181576 DOI: 10.1002/Chin.197640258 |
0.377 |
|
| 1975 |
Hwang KM, Murphree SA, Shansky CW, Sartorelli AC. Sequential biochemical events related to DNA replication in the regenerating rat liver. Biochimica Et Biophysica Acta. 366: 143-8. PMID 4616722 DOI: 10.1016/0005-2787(74)90328-1 |
0.332 |
|
| 1975 |
Sartorelli AC, Hwang KM, Murphree SA, Carrico CK. The effect of urethan on cyclic events in the regenerating rat liver Advances in Enzyme Regulation. 13: 295-313. PMID 1211289 DOI: 10.1016/0065-2571(75)90021-7 |
0.35 |
|
| 1975 |
Tsiftsoglou AS, Hwang KM, Agrawal KC, Sartorelli AC. Strand-scission of Sarcoma 180 tumor cell DNA induced by 1-formylisoquinoline thiosemicarbazone Biochemical Pharmacology. 24: 1631-1633. PMID 1191322 DOI: 10.1016/0006-2952(75)90091-X |
0.367 |
|
| 1975 |
Men Hui Lee, Yow-Mei H, Agrawal KC, Sartorelli AC. Inhibitors of alkaline phosphatase of Sarcoma 180/TG Biochemical Pharmacology. 24: 1175-1178. PMID 1169946 DOI: 10.1016/0006-2952(75)90058-1 |
0.342 |
|
| 1975 |
Myers MW, Sartorelli AC. The effects of low concentrations of 2-deoxy-D-glucose on the growth, surface architecture, and glycoprotein metabolism of P388 lymphoma cells. Biochemical and Biophysical Research Communications. 63: 164-71. PMID 1168461 DOI: 10.1016/S0006-291X(75)80025-8 |
0.335 |
|
| 1975 |
Lin AJ, Lillis BJ, Sartorelli AC. Potential bioreductive alkylating agents. 5. Antineoplastic activity of quinoline-5,8-diones, naphthazarins, and naphthoquinones Journal of Medicinal Chemistry. 18: 917-921. PMID 1159713 DOI: 10.1002/Chin.197602160 |
0.359 |
|
| 1975 |
Agrawal KC, Booth BA, DeNuzzo SM, Sartorelli AC. Potential antitumor agents. 12. 2-Formyl-4-aminophenylpyridine thiosemicarbazones. Journal of Medicinal Chemistry. 18: 368-71. PMID 1121002 DOI: 10.1021/Jm00238A009 |
0.345 |
|
| 1975 |
AGRAWAL KC, LEE MH, BOOTH BA, MOORE EC, SARTORELLI AC. ChemInform Abstract: POTENTIAL ANTITUMOR AGENTS PART 11, INHIBITORS OF ALKALINE PHOSPHATASE, AN ENZYME INVOLVED IN THE RESISTANCE OF NEOPLASTIC CELLS TO 6-THIOPURINES Chemischer Informationsdienst. 6: no-no. DOI: 10.1002/Chin.197501276 |
0.375 |
|
| 1974 |
Lin AJ, Shansky CW, Sartorelli AC. Potential bioreductive alkylating agents. 3. Synthesis and antineoplastic activity of acetoxymethyl and corresponding ethyl carbamate derivatives of benzoquinones Journal of Medicinal Chemistry. 17: 558-561. PMID 4830263 DOI: 10.1021/Jm00251A026 |
0.341 |
|
| 1974 |
Lee MH, Sartorelli AC. Solubilization and partial purification of alkaline phosphatases of sarcoma 180-TG ascites cells. Biochimica Et Biophysica Acta. 358: 69-81. PMID 4212343 DOI: 10.1016/0005-2744(74)90259-9 |
0.352 |
|
| 1974 |
LIN AJ, PARDINI RS, LILLIS BJ, SARTORELLI AC. ChemInform Abstract: POTENTIAL BIOREDUCTIVE ALKYLATING AGENTS PART 4, INHIBITION OF COENZYME Q ENZYME SYSTEMS BY LIPOIDAL BENZOQUINONE AND NAPHTHOQUINONE DERIVATIVES Chemischer Informationsdienst. 5: no-no. DOI: 10.1002/Chin.197446234 |
0.301 |
|
| 1974 |
AI JENG LIN AJL, PARDINI RS, COSBY LA, LILLIS BJ, SHANSKY CW, SARTORELLI AC. ChemInform Abstract: POTENTIAL BIOREDUCTIVE ALKYLATING AGENTS PART 2, ANTITUMOR EFFECT AND BIOCHEMICAL STUDIES OF NAPHTHOQUINONE DERIVATIVES Chemischer Informationsdienst. 5: no-no. DOI: 10.1002/Chin.197409253 |
0.325 |
|
| 1973 |
Men Hue Lee, Sznycer-Bochner E, Agrawal KC, Wolpert MK, Sartorelli AC. Development of inhibitors of alkaline phosphatase-an enzyme involved in resistance of sarcoma 180/TG to 6-thiopurines Biochemical Pharmacology. 22: 1477-1485. PMID 4738893 DOI: 10.1016/0006-2952(73)90325-0 |
0.326 |
|
| 1973 |
Hochman HI, Agrawal KC, Shansky CW, Sartorelli AC. Synthesis of site‐directed chelating agents I: Pteridine carboxaldehyde thiosemicarbazones Journal of Pharmaceutical Sciences. 62: 150-151. PMID 4682920 DOI: 10.1002/Jps.2600620135 |
0.324 |
|
| 1973 |
Lin AJ, Pardini RS, Cosby LA, Lillis BJ, Shansky CW, Sartorelli AC. Potential bioreductive alkylating agents. 2. Antitumor effect and biochemical studies of naphthoquinone derivatives Journal of Medicinal Chemistry. 16: 1268-1271. PMID 4147836 DOI: 10.1021/Jm00269A010 |
0.4 |
|
| 1972 |
Lin AJ, Agrawal KC, Sartorelli AC. Potential antitumor agents. 8. Derivatives of 3- and 5-benzyloxy-2-formylpyridinethiosemicarbazone Journal of Medicinal Chemistry. 15: 615-618. PMID 5030928 DOI: 10.1021/Jm00276A012 |
0.336 |
|
| 1972 |
Lin AJ, Cosby LA, Shansky CW, Sartorelli AC. Potential bioreductive alkylating agents. 1. Benzoquinone derivatives Journal of Medicinal Chemistry. 15: 1247-1252. PMID 4635968 DOI: 10.1021/Jm00282A011 |
0.389 |
|
| 1972 |
Hochman HI, Agrawal KC, Sartorelli AC. Localization in Escherichia coli B of two enzymatic sites of action by 1-formylisoquinoline thiosemicarbazone (IQ-1) on ribonucleic acid biosynthetic pathways Biochemical Pharmacology. 21: 3223-3233. PMID 4567526 DOI: 10.1016/0006-2952(72)90087-1 |
0.32 |
|
| 1972 |
Hochman HI, Agrawal KC, Sartorelli AC. Biochemical studies of the effects of 1-formylisoquinoline thiosemicarbazone (IQ-1) in escherichia coli B Biochemical Pharmacology. 21: 3213-3221. PMID 4567525 DOI: 10.1016/0006-2952(72)90086-X |
0.345 |
|
| 1972 |
Agrawal KC, Booth BA, Moore EC, Sartorelli AC. Potential antitumor agents. 6. Possible irreversible inhibitors of ribonucleoside diphosphate reductase. Journal of Medicinal Chemistry. 15: 1154-8. PMID 4347551 DOI: 10.1021/Jm00281A015 |
0.316 |
|
| 1971 |
Anderson JH, Sartorelli AC. Inhibition of inosinic acid dehydrogenase of sarcoma 180 ascites cells by nucleotides and their analogs. Biochemical Pharmacology. 18: 2747-57. PMID 5408608 DOI: 10.1016/0006-2952(69)90182-8 |
0.378 |
|
| 1971 |
Booth BA, Donnelly TE, Zettner A, Sartorelli AC. Metabolic effects of zinc in intact cells--comparative studies of zinc chloride and the zinc chelate of kethoxal bis(thiosemicarbazone). Biochemical Pharmacology. 20: 3109-18. PMID 5132115 DOI: 10.1016/0006-2952(71)90115-8 |
0.362 |
|
| 1971 |
Sartorelli AC, Agrawal KC, Moore EC. Mechanism of inhibition of ribonucleoside diphosphate reductase by a-(N)-heterocyclic aldehyde thiosemicarbazones. Biochemical Pharmacology. 20: 3119-23. PMID 4332051 DOI: 10.1016/0006-2952(71)90116-X |
0.396 |
|
| 1970 |
Agrawal KC, Cushley RJ, Mcmurray WJ, Sartorelli AC. Potential antitumor agents. IV. 4-substituted 1-formylisoquinoline thiosemicarbazones Journal of Medicinal Chemistry. 13: 431-434. PMID 5466487 DOI: 10.1021/Jm00297A023 |
0.363 |
|
| 1969 |
Agrawal KC, Sartorelli AC. Potential antitumor agents. II. Effects of modifications in the side chain of 1-formylisoquinoline thiosemicarbazone Journal of Medicinal Chemistry. 12: 771-774. PMID 5812185 DOI: 10.1021/Jm00305A011 |
0.367 |
|
| 1969 |
Cramer GT, Sartorelli AC. Studies on the mechanism of the azaserine-induced decrease in the activity of thymidine kinase. Biochemical Pharmacology. 18: 1355-62. PMID 5799109 DOI: 10.1016/0006-2952(69)90248-2 |
0.411 |
|
| 1969 |
Anderson JH, Sartorelli AC. Inhibition of inosinic acid dehydrogenase by 6-chloropurine nucleotide Biochemical Pharmacology. 18: 2737-2745. DOI: 10.1016/0006-2952(69)90181-6 |
0.328 |
|
| 1968 |
Agrawal KC, Booth BA, Sartorelli AC. Potential antitumor agents. I. A series of 5-substituted 1-formylisoquinoline thiosemicarbazones. Journal of Medicinal Chemistry. 11: 700-3. PMID 5671227 DOI: 10.1021/Jm00310A014 |
0.301 |
|
| 1968 |
Booth BA, Johns DG, Bertino JR, Sartorelli AC. Sites of inhibition of DNA synthesis by kethoxal bis(thiosemicarbazone). Nature. 217: 250-1. PMID 5237633 DOI: 10.1038/217250A0 |
0.323 |
|
| 1967 |
Sartorelli AC. Effect of chelating agents upon the synthesis of nucleic acids and protein: inhibition of DNA synthesis by 1-formylisoquinoline thiosemicarbazone. Biochemical and Biophysical Research Communications. 27: 26-32. PMID 6048237 DOI: 10.1016/S0006-291X(67)80034-2 |
0.334 |
|
| 1964 |
SARTORELLI AC, BOOTH BA, BERTINO JR. FOLATE METABOLISM IN METHOTREXATE-SENSITIVE AND -RESISTANT EHRLICH ASCITES CELLS. Archives of Biochemistry and Biophysics. 108: 53-9. PMID 14233916 DOI: 10.1016/0003-9861(64)90354-6 |
0.373 |
|
| 1964 |
Bakhle YS, Creasey WA, Sartorelli AC, Prusoff WH. Some biological and biochemical properties of 5-iodocytosine Biochemical Pharmacology. 13: 1249-1259. PMID 14222522 DOI: 10.1016/0006-2952(64)90126-1 |
0.328 |
|
| 1964 |
Bieber AL, Sartorelli AC. Enzymatic Synthesis and some Biochemical Effects of 2′-Deoxy-6-thioguanosine Nature. 201: 624-624. PMID 14160661 DOI: 10.1038/201624A0 |
0.345 |
|
| 1964 |
Sartorelli AC. Combination Chemotherapy with Actinomycin D and Ribonuclease : an Example of Complementary Inhibition Nature. 203: 877-878. DOI: 10.1038/203877A0 |
0.326 |
|
| 1963 |
SARTORELLI AC, BOOTH BA. SOME FACTORS AFFECTING THE TUMOR-INHIBITORY PROPERTIES OF COMBINATIONS OF AZASERINE AND 6-CHLOROPURINE. Biochemical Pharmacology. 12: 847-53. PMID 14071542 DOI: 10.1016/0006-2952(63)90115-1 |
0.352 |
|
| 1962 |
Cramer JW, Prusoff WH, Welch AD, Sartorelli AC, Delamore IW, Von Essen CF, Chang PK. Studies on the biochemical pharmacology of 5-IODO-2'-deoxycytidine in vitro and in vivo Biochemical Pharmacology. 11: 761-768. PMID 13881995 DOI: 10.1016/0006-2952(62)90044-8 |
0.402 |
|
| 1960 |
SARTORELLI AC, BOOTH BA. Modifications in purine metabolism induced by 6-chloropurine. Archives of Biochemistry and Biophysics. 89: 118-22. PMID 14441825 DOI: 10.1016/0003-9861(60)90021-7 |
0.343 |
|
| 1960 |
SARTORELLI AC, BOOTH BA. Utilization of preformed purines by sarcoma 180 or hepatoma 134 cells treated with 6-chloropurine or a combination of 6-chloropurine and azaserine. Biochemical Pharmacology. 5: 245-50. PMID 13746610 DOI: 10.1016/0006-2952(60)90070-8 |
0.356 |
|
| 1960 |
SARTORELLI AC, AKERS JR, BOOTH BA. Inhibition of the biosynthesis of purines de novo by 6-chloropurine and azaserine in sensitive and naturally resistant ascites cells. Biochemical Pharmacology. 5: 238-44. PMID 13746609 DOI: 10.1016/0006-2952(60)90069-1 |
0.364 |
|
| Show low-probability matches. |