Year |
Citation |
Score |
2021 |
Liu Z, Ma L, Sun Y, Yu W, Wang X. Targeting STAT3 signaling overcomes gefitinib resistance in non-small cell lung cancer. Cell Death & Disease. 12: 561. PMID 34059647 DOI: 10.1038/s41419-021-03844-z |
0.321 |
|
2021 |
Ren Y, Li S, Zhu R, Wan C, Song D, Zhu J, Cai G, Long S, Kong L, Yu W. Discovery of STAT3 and Histone Deacetylase (HDAC) Dual-Pathway Inhibitors for the Treatment of Solid Cancer. Journal of Medicinal Chemistry. PMID 34043359 DOI: 10.1021/acs.jmedchem.1c00136 |
0.406 |
|
2021 |
Chen RL, Wang Z, Huang P, Sun CH, Yu WY, Zhang HH, Yu CH, He JQ. Isovitexin potentiated the antitumor activity of cisplatin by inhibiting the glucose metabolism of lung cancer cells and reduced cisplatin-induced immunotoxicity in mice. International Immunopharmacology. 107357. PMID 33715980 DOI: 10.1016/j.intimp.2020.107357 |
0.324 |
|
2020 |
Song D, Yu W, Ren Y, Zhu J, Wan C, Cai G, Guo J, Zhang W, Kong L. Discovery of bazedoxifene analogues targeting glycoprotein 130. European Journal of Medicinal Chemistry. 199: 112375. PMID 32388278 DOI: 10.1016/J.Ejmech.2020.112375 |
0.431 |
|
2020 |
Xu G, Zhang Y, Wang H, Guo Z, Wang X, Li X, Chang S, Sun T, Yu Z, Xu T, Zhao L, Wang Y, Yu W. Synthesis and biological evaluation of 4-(pyridin-4-oxy)-3-(3,3-difluorocyclobutyl)-pyrazole derivatives as novel potent transforming growth factor-β type 1 receptor inhibitors. European Journal of Medicinal Chemistry. 198: 112354. PMID 32387837 DOI: 10.1016/J.Ejmech.2020.112354 |
0.318 |
|
2020 |
Pan L, Chen X, Fu S, Yu W, Li C, Wang T, Lo HW, Lin J. LLY17, a novel small molecule STAT3 inhibitor induces apoptosis and suppresses cell migration and tumor growth in triple-negative breast cancer. Breast Cancer Research and Treatment. PMID 32240456 DOI: 10.1007/S10549-020-05613-6 |
0.556 |
|
2020 |
Wang H, Liu Z, Guan L, Li J, Chen S, Yu W, Lai M. LYW-6, a Novel Cryptotanshinone Derived STAT3 Targeting Inhibitor, Suppresses Colorectal Cancer Growth and Metastasis. Pharmacological Research. 104661. PMID 31982491 DOI: 10.1016/j.phrs.2020.104661 |
0.438 |
|
2019 |
Zhu J, Chen J, Song D, Zhang W, Guo J, Cai G, Ren Y, Wan C, Kong L, Yu W. Real-time monitoring of etoposide prodrug activated by hydrogen peroxide with improved safety. Journal of Materials Chemistry. B. PMID 31720667 DOI: 10.1039/C9Tb02041A |
0.35 |
|
2019 |
Liu Z, Wang H, Guan L, Lai C, Yu W, Lai M. LL1, a novel specific STAT3 inhibitor, displays anti-colorectal cancer activities in vitro and in vivo. British Journal of Pharmacology. PMID 31499589 DOI: 10.1111/bph.14863 |
0.412 |
|
2019 |
Li Y, Wang Y, Shi Z, Liu J, Zheng S, Yang J, Liu Y, Yang Y, Chang F, Yu W. Clinicopathological and Prognostic Role of STAT3/p-STAT3 in Breast Cancer Patients in China: A Meta-Analysis. Scientific Reports. 9: 11243. PMID 31375715 DOI: 10.1038/S41598-019-47556-Z |
0.341 |
|
2019 |
Cai G, Yu W, Song D, Zhang W, Guo J, Zhu J, Ren Y, Kong L. Discovery of fluorescent coumarin-benzo[b]thiophene 1, 1-dioxide conjugates as mitochondria-targeting antitumor STAT3 inhibitors. European Journal of Medicinal Chemistry. 174: 236-251. PMID 31048139 DOI: 10.1016/J.Ejmech.2019.04.024 |
0.461 |
|
2018 |
Zhang W, Yu W, Cai G, Zhu J, Zhang C, Li S, Guo J, Yin G, Chen C, Kong L. A new synthetic derivative of cryptotanshinone KYZ3 as STAT3 inhibitor for triple-negative breast cancer therapy. Cell Death & Disease. 9: 1098. PMID 30368518 DOI: 10.1038/S41419-018-1139-Z |
0.519 |
|
2018 |
Guo J, Yu W, Cai G, Zhang W, Li S, Zhu J, Song D, Kong L. Discovery of new benzensulfonamide derivatives as tripedal STAT3 inhibitors. European Journal of Medicinal Chemistry. 151: 752-764. PMID 29674294 DOI: 10.1016/J.Ejmech.2018.03.053 |
0.55 |
|
2017 |
Zhang W, Liu F, Zhang C, Luo JG, Luo J, Yu W, Kong L. Near-infrared Fluorescent Probe with Remarkable Large Stokes Shift and Favorable Water Solubility for Real-time Tracking Leucine Aminopeptidase In Living Cells and In Vivo. Analytical Chemistry. PMID 29048879 DOI: 10.1021/Acs.Analchem.7B03332 |
0.362 |
|
2017 |
Zhang W, Guo J, Li S, Ma T, Xu D, Han C, Liu F, Yu W, Kong L. Discovery of monocarbonyl curcumin-BTP hybrids as STAT3 inhibitors for drug-sensitive and drug-resistant breast cancer therapy. Scientific Reports. 7: 46352. PMID 28397855 DOI: 10.1038/Srep46352 |
0.518 |
|
2017 |
Yu W, Li C, Zhang W, Xia Y, Li S, Lin J, Yu K, Liu M, Yang L, Luo JG, Chen Y, Sun H, Kong LY. Discovery of an Orally Selective Inhibitor of Signal Transducer and Activator of Transcription 3 Using Advanced Multiple Ligand Simultaneous Docking. Journal of Medicinal Chemistry. PMID 28245116 DOI: 10.1021/Acs.Jmedchem.6B01489 |
0.584 |
|
2016 |
Li S, Zhang W, Yang Y, Ma T, Guo J, Wang S, Yu W, Kong L. Discovery of oral-available resveratrol-caffeic acid based hybrids inhibiting acetylated and phosphorylated STAT3 protein. European Journal of Medicinal Chemistry. 124: 1006-1018. PMID 27783972 DOI: 10.1016/J.Ejmech.2016.10.028 |
0.536 |
|
2016 |
Zhang W, Ma T, Li S, Yang Y, Guo J, Yu W, Kong L. Antagonizing STAT3 activation with benzo[b]thiophene 1, 1-dioxide based small molecules. European Journal of Medicinal Chemistry. 125: 538-550. PMID 27718470 DOI: 10.1016/J.Ejmech.2016.09.068 |
0.546 |
|
2015 |
Che XH, Chen CL, Ye XL, Weng GB, Guo XZ, Yu WY, Tao J, Chen YC, Chen X. Dual inhibition of COX-2/5-LOX blocks colon cancer proliferation, migration and invasion in vitro. Oncology Reports. PMID 26707712 DOI: 10.3892/or.2015.4506 |
0.329 |
|
2015 |
Xie SS, Wang X, Jiang N, Yu W, Wang KD, Lan JS, Li ZR, Kong LY. Multi-target tacrine-coumarin hybrids: Cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease. European Journal of Medicinal Chemistry. 95: 153-65. PMID 25812965 DOI: 10.1016/J.Ejmech.2015.03.040 |
0.372 |
|
2015 |
Xiao H, Bid HK, Jou D, Wu X, Yu W, Li C, Houghton PJ, Lin J. A novel small molecular STAT3 inhibitor, LY5, inhibits cell viability, cell migration, and angiogenesis in medulloblastoma cells. The Journal of Biological Chemistry. 290: 3418-29. PMID 25313399 DOI: 10.1074/Jbc.M114.616748 |
0.615 |
|
2014 |
Xu ZC, Wang XB, Yu WY, Xie SS, Li SY, Kong LY. Design, synthesis and biological evaluation of benzylisoquinoline derivatives as multifunctional agents against Alzheimer's disease. Bioorganic & Medicinal Chemistry Letters. 24: 2368-73. PMID 24726809 DOI: 10.1016/J.Bmcl.2014.03.058 |
0.321 |
|
2014 |
Yu W, Li C. Regioselective one-pot C-N coupling of substituted naphthoquinones: Selective intramolecular ring fusion of sulfonamides Tetrahedron. 70: 459-464. DOI: 10.1016/J.Tet.2013.11.041 |
0.402 |
|
2013 |
Yu W, Xiao H, Lin J, Li C. Discovery of novel STAT3 small molecule inhibitors via in silico site-directed fragment-based drug design. Journal of Medicinal Chemistry. 56: 4402-12. PMID 23651330 DOI: 10.1021/Jm400080C |
0.577 |
|
2013 |
Yu W, Li C. 4-Nitro-phenyl N-(2-sulfamoylphen-yl)carbamate. Acta Crystallographica. Section E, Structure Reports Online. 69: o355. PMID 23476546 DOI: 10.1107/S1600536813003310 |
0.328 |
|
2013 |
Xiao H, Yu W, Olson VR, Li C, Houghton P, Lin J. Abstract 3252: A novel small molecule, LY5, selectively inhibits STAT3 phosphorylation and activities and exhibits potent growth suppressive activity in cancer cells. Cancer Research. 73: 3252-3252. DOI: 10.1158/1538-7445.Am2013-3252 |
0.629 |
|
2011 |
Liu A, Liu Y, Xu Z, Yu W, Wang H, Li C, Lin J. Novel small molecule, XZH-5, inhibits constitutive and interleukin-6-induced STAT3 phosphorylation in human rhabdomyosarcoma cells. Cancer Science. 102: 1381-7. PMID 21435102 DOI: 10.1111/J.1349-7006.2011.01932.X |
0.614 |
|
2011 |
Liu Y, Liu A, Xu Z, Yu W, Wang H, Li C, Lin J. XZH-5 inhibits STAT3 phosphorylation and causes apoptosis in human hepatocellular carcinoma cells. Apoptosis : An International Journal On Programmed Cell Death. 16: 502-10. PMID 21311975 DOI: 10.1007/S10495-011-0578-0 |
0.552 |
|
2011 |
Liu A, Liu Y, Xu Z, Yu W, Wang H, Li C, Lin J. Abstract 5345: A novel small molecule, XZH-5 inhibits constitutive and interleukin-6-induced STAT3 phosphorylation in human rhabdomyosarcoma cells Cancer Research. 71: 5345-5345. DOI: 10.1158/1538-7445.Am2011-5345 |
0.629 |
|
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