Polo C. Lam, Ph.D.
Affiliations: | 2004 | Virginia Polytechnic Institute and State University, Blacksburg, VA, United States |
Area:
Stereoselective synthesis, medicinal chemistryGoogle:
"Polo Lam"Mean distance: 8.92 | S | N | B | C | P |
Parents
Sign in to add mentor| Paul R. Carlier | grad student | 2004 | Virginia Tech | |
| (Experimental and computational studies in bioorganic and synthetic organic chemistry.) | ||||
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Publications
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| Han Q, Wong DM, Robinson H, et al. (2017) Crystal structure of acetylcholinesterase catalytic subunits of the malaria vector Anopheles gambiae. Insect Science |
| Mutunga JM, Chen QH, Wong DM, et al. (2016) Bivalent Carbamates as Novel Control Agents of the Malaria Mosquito, Anopheles gambiae. Chimia. 70: 704-708 |
| Verma A, Wong DM, Islam R, et al. (2015) 3-Oxoisoxazole-2(3H)-carboxamides and isoxazol-3-yl carbamates: Resistance-breaking acetylcholinesterase inhibitors targeting the malaria mosquito, Anopheles gambiae. Bioorganic & Medicinal Chemistry. 23: 1321-40 |
| Swale DR, Tong F, Temeyer KB, et al. (2013) Inhibitor profile of bis(n)-tacrines and N-methylcarbamates on acetylcholinesterase from Rhipicephalus (Boophilus) microplus and Phlebotomus papatasi. Pesticide Biochemistry and Physiology. 106 |
| Mutunga JM, Boina DR, Anderson TD, et al. (2013) Neurotoxicology of bis(n)-tacrines on Blattella germanica and Drosophila melanogaster acetylcholinesterase. Archives of Insect Biochemistry and Physiology. 83: 180-94 |
| Wong DM, Li J, Lam PC, et al. (2013) Aryl methylcarbamates: potency and selectivity towards wild-type and carbamate-insensitive (G119S) Anopheles gambiae acetylcholinesterase, and toxicity to G3 strain An. gambiae. Chemico-Biological Interactions. 203: 314-8 |
| Wong DM, Li J, Chen QH, et al. (2012) Select small core structure carbamates exhibit high contact toxicity to "carbamate-resistant" strain malaria mosquitoes, Anopheles gambiae (Akron). Plos One. 7: e46712 |
| Hartsel JA, Wong DM, Mutunga JM, et al. (2012) Re-engineering aryl methylcarbamates to confer high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase. Bioorganic & Medicinal Chemistry Letters. 22: 4593-8 |
| Monceaux CJ, Hirata-Fukae C, Lam PC, et al. (2011) Triazole-linked reduced amide isosteres: an approach for the fragment-based drug discovery of anti-Alzheimer's BACE1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 3992-6 |
| Hsu DC, Lam PC, Slebodnick C, et al. (2009) Complete mapping of the stereochemical course of retentive deprotonation/alkylation of 1H-benzo[e][1,4]diazepin-2(3H)-ones. Journal of the American Chemical Society. 131: 18168-76 |