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Jared T. Hammill, Ph.D. - Publications

Affiliations: 
2012 Chemistry University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Chemical Biology
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23 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Kim HS, Ortiz D, Kadayat TM, Fargo CM, Hammill JT, Chen Y, Rice AL, Begley KL, Shoeran G, Pistel W, Yates PA, Sanchez MA, Landfear SM, Guy RK. Optimization of Orally Bioavailable Antileishmanial 2,4,5-Trisubstituted Benzamides. Journal of Medicinal Chemistry. PMID 37216489 DOI: 10.1021/acs.jmedchem.3c00056  0.682
2021 Hammill JT, Sviripa VM, Kril LM, Ortiz D, Fargo CM, Kim HS, Chen Y, Rector J, Rice AL, Domagalska MA, Begley KL, Liu C, Rangnekar VM, Dujardin JC, Watt DS, et al. Amino-Substituted 3-Aryl- and 3-Heteroarylquinolines as Potential Antileishmanial Agents. Journal of Medicinal Chemistry. PMID 34355566 DOI: 10.1021/acs.jmedchem.1c00813  0.325
2021 Eagon S, Hammill JT, Fitzsimmons K, Sienko N, Nguyen B, Law J, Manjunath A, Wilkinson SP, Thompson K, Elizabeth Glidden J, Rice AL, Falade MO, Kimball JJ, DiBernardo C, Kiplin Guy R. Antimalarial Activity of 2,6-Dibenzylidenecyclohexanone Derivatives. Bioorganic & Medicinal Chemistry Letters. 128216. PMID 34157390 DOI: 10.1016/j.bmcl.2021.128216  0.347
2021 Kim HS, Hammill JT, Scott DC, Chen Y, Rice AL, Pistel W, Singh B, Schulman BA, Guy RK. Improvement of Oral Bioavailability of Pyrazolo-Pyridone Inhibitors of the Interaction of DCN1/2 and UBE2M. Journal of Medicinal Chemistry. PMID 33945681 DOI: 10.1021/acs.jmedchem.1c00035  0.352
2021 Everson N, Bach J, Hammill JT, Falade MO, Rice AL, Guy RK, Eagon S. Identification of Plasmodium falciparum heat shock 90 inhibitors via molecular docking. Bioorganic & Medicinal Chemistry Letters. 35: 127818. PMID 33513390 DOI: 10.1016/j.bmcl.2021.127818  0.416
2020 Barrows RD, Hammill JT, Tran MC, Falade MO, Rice AL, Davis CW, Emge TJ, Rablen PR, Kiplin Guy R, Knapp S. Evaluation of 1,1-cyclopropylidene as a thioether isostere in the 4-thio-thienopyrimidine (TTP) series of antimalarials. Bioorganic & Medicinal Chemistry. 28: 115758. PMID 33007559 DOI: 10.1016/J.Bmc.2020.115758  0.325
2020 Eagon S, Hammill JT, Sigal MS, Ahn KJ, Tryhorn JE, Koch G, Belanger B, Chaplan CA, Loop L, Kashtanova AS, Yniguez K, Lazaro H, Wilkinson SP, Rice A, Falade M, et al. Synthesis and structure-activity relationship of dual-stage antimalarial pyrazolo[3,4-b]pyridines. Journal of Medicinal Chemistry. PMID 32945666 DOI: 10.1021/Acs.Jmedchem.0C01152  0.664
2020 Eagon S, Hammill JT, Bach J, Everson N, Sisley TA, Walls MJ, Durham S, Pillai DR, Falade MO, Rice AL, Kimball JJ, Lazaro H, DiBernardo C, Kiplin Guy R. Antimalarial activity of tetrahydro-β-carbolines targeting the ATP binding pocket of the Plasmodium falciparum heat shock 90 protein. Bioorganic & Medicinal Chemistry Letters. 30: 127502. PMID 32822760 DOI: 10.1016/J.Bmcl.2020.127502  0.476
2019 Kim HS, Hammill JT, Scott DC, Chen Y, Min J, Rector J, Singh B, Schulman BA, Guy RK. Discovery of Novel Pyrazolo-Pyridone DCN1 Inhibitors Controlling Cullin Neddylation. Journal of Medicinal Chemistry. PMID 31465221 DOI: 10.1021/Acs.Jmedchem.9B00410  0.624
2018 Hammill JT, Scott DC, Min J, Connelly MC, Holbrook G, Zhu F, Matheny A, Yang L, Singh B, Schulman BA, Guy RK. Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-mediated Cullin Neddylation. Journal of Medicinal Chemistry. PMID 29547696 DOI: 10.1021/Acs.Jmedchem.7B01277  0.627
2018 Hammill JT, Bhasin D, Scott DC, Min J, Chen Y, Lu Y, Yang L, Kim HS, Connelly MC, Hammill C, Holbrook G, Jeffries C, Singh B, Schulman BA, Guy RK. Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-mediated Cullin Neddylation. Journal of Medicinal Chemistry. PMID 29547693 DOI: 10.1021/Acs.Jmedchem.7B01282  0.642
2017 Ortiz D, Guiguemde WA, Hammill JT, Carrillo AK, Chen Y, Connelly M, Stalheim K, Elya C, Johnson A, Min J, Shelat A, Smithson DC, Yang L, Zhu F, Guy RK, et al. Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening. Plos Neglected Tropical Diseases. 11: e0006157. PMID 29287089 DOI: 10.1371/Journal.Pntd.0006157  0.658
2017 Scott DC, Hammill JT, Min J, Rhee DY, Connelly M, Sviderskiy VO, Bhasin D, Chen Y, Ong SS, Chai SC, Goktug AN, Huang G, Monda JK, Low J, Kim HS, et al. Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase. Nature Chemical Biology. PMID 28581483 DOI: 10.1038/Nchembio.2386  0.626
2017 Kim HS, Hammill JT, Guy RK. Seeking the Elusive Long-Acting Ozonide: Discovery of Artefenomel (OZ439). Journal of Medicinal Chemistry. PMID 28296396 DOI: 10.1021/Acs.Jmedchem.7B00299  0.563
2017 Barrios R, Hammill J, Min J, Guy K. Abstract 5237: Targeting DCN1-mediated neddylation in lung SCC with novel small-molecule inhibitors Cancer Research. 77: 5237-5237. DOI: 10.1158/1538-7445.Am2017-5237  0.48
2016 Min J, Scott DC, Chai SC, Goktug AN, Hammill JT, Huang G, Connelly MC, Matheny A, Shelat A, Singh B, Chen T, Schulman BA, Guy RK. Abstract LB-056: Discovery of novel small molecule inhibitors of the DCN1-Ubc12 interaction by high throughput screening technology Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Lb-056  0.62
2013 Keffer JL, Huecas S, Hammill JT, Wipf P, Andreu JM, Bewley CA. Chrysophaentins are competitive inhibitors of FtsZ and inhibit Z-ring formation in live bacteria. Bioorganic & Medicinal Chemistry. 21: 5673-8. PMID 23932448 DOI: 10.1016/J.Bmc.2013.07.033  0.54
2013 Zuniga J, Hammill J, Drory O, Nuss J, Burnett J, Gussio R, Wipf P, Bavari S, Brunger A. Structural basis for the inhibition of botulinum neurotoxin serotype A by potent peptidomimetics Toxicon. 68: 103-104. DOI: 10.1016/J.Toxicon.2012.07.122  0.494
2012 Keffer JL, Hammill JT, Lloyd JR, Plaza A, Wipf P, Bewley CA. Geographic variability and anti-staphylococcal activity of the chrysophaentins and their synthetic fragments. Marine Drugs. 10: 1103-25. PMID 22822360 DOI: 10.3390/Md10051103  0.504
2010 Hammill JT, Contreras-García J, Virshup AM, Beratan D, Yang W, Wipf P. Synthesis and chemical diversity analysis of bicyclo[3.3.1]non-3-en-2-ones. Tetrahedron. 66: 5852-5862. PMID 20798897 DOI: 10.1016/J.Tet.2010.04.112  0.424
2010 Zuniga JE, Hammill JT, Drory O, Nuss JE, Burnett JC, Gussio R, Wipf P, Bavari S, Brunger AT. Iterative structure-based peptide-like inhibitor design against the botulinum neurotoxin serotype A. Plos One. 5: e11378. PMID 20614028 DOI: 10.1371/Journal.Pone.0011378  0.483
2010 Miyake-Stoner SJ, Refakis CA, Hammill JT, Lusic H, Hazen JL, Deiters A, Mehl RA. Generating permissive site-specific unnatural aminoacyl-tRNA synthetases. Biochemistry. 49: 1667-77. PMID 20082521 DOI: 10.1021/Bi901947R  0.314
2007 Jackson JC, Hammill JT, Mehl RA. Site-specific incorporation of a (19)F-amino acid into proteins as an NMR probe for characterizing protein structure and reactivity. Journal of the American Chemical Society. 129: 1160-6. PMID 17263397 DOI: 10.1021/Ja064661T  0.316
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