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Andrew C. Flick, Ph.D. - Publications

Affiliations: 
2008 Chemistry Emory University, Atlanta, GA 
Area:
synthesis of heterocyclic compounds
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29/45 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 France SP, Lindsey EA, McInturff EL, Berritt S, Carney DW, DeForest JC, Fink SJ, Flick AC, Gibson TS, Gray K, Johnson AM, Leverett CA, Liu Y, Mahapatra S, Watson RB. Synthetic Approaches to the New Drugs Approved During 2022. Journal of Medicinal Chemistry. PMID 38488755 DOI: 10.1021/acs.jmedchem.3c02374  0.807
2023 McInturff EL, France SP, Leverett CA, Flick AC, Lindsey EA, Berritt S, Carney DW, DeForest JC, Ding HX, Fink SJ, Gibson TS, Gray K, Hubbell AK, Johnson AM, Liu Y, et al. Synthetic Approaches to the New Drugs Approved During 2021. Journal of Medicinal Chemistry. PMID 37528515 DOI: 10.1021/acs.jmedchem.3c00501  0.823
2022 Flick AC, Leverett CA, Ding HX, McInturff EL, Fink SJ, Mahapatra S, Carney DW, Lindsey EA, DeForest JC, France SP, Berritt S, Bigi-Botterill SV, Gibson TS, Watson RB, Liu Y, et al. Synthetic Approaches to the New Drugs Approved During 2020. Journal of Medicinal Chemistry. PMID 35833579 DOI: 10.1021/acs.jmedchem.2c00710  0.823
2021 Flick AC, Leverett CA, Ding HX, McInturff E, Fink SJ, Mahapatra S, Carney DW, Lindsey EA, DeForest JC, France SP, Berritt S, Bigi-Botterill SV, Gibson TS, Liu Y, O'Donnell CJ. Synthetic Approaches to the New Drugs Approved during 2019. Journal of Medicinal Chemistry. PMID 33783211 DOI: 10.1021/acs.jmedchem.1c00208  0.821
2020 Flick A, Leverett CA, Ding HX, McInturff EL, Fink S, Helal C, Deforest J, Morse P, Mahapatra S, O'Donnell CJ. Synthetic Approaches to the New Drugs Approved During 2018. Journal of Medicinal Chemistry. PMID 32338902 DOI: 10.1021/Acs.Jmedchem.0C00345  0.832
2019 Flick AC, Leverett CA, Ding HX, McInturff EL, Fink SJ, Helal CJ, O'Donnell CJ. Synthetic Approaches to the New Drugs Approved During 2017. Journal of Medicinal Chemistry. PMID 30939001 DOI: 10.1021/acs.jmedchem.9b00196  0.832
2018 Flick A, Ding HX, Leverett CA, Fink SJ, O'Donnell CJ. Synthetic Approaches to New Drugs Approved During 2016. Journal of Medicinal Chemistry. PMID 29620889 DOI: 10.1021/acs.jmedchem.8b00260  0.832
2017 Flick AC, Ding HX, Leverett CA, Kyne RE, Liu KK, Fink SJ, O'Donnell CJ. Correction to Synthetic Approaches to the New Drugs Approved During 2015. Journal of Medicinal Chemistry. PMID 29035530 DOI: 10.1021/Acs.Jmedchem.7B01452  0.799
2017 Flick AC, Ding HX, Leverett CA, Kyne RE, Liu KK, Fink SJ, O'Donnell CJ. Synthetic Approaches to New Drugs Approved During 2015. Journal of Medicinal Chemistry. PMID 28421763 DOI: 10.1021/acs.jmedchem.7b00010  0.832
2016 Flick AC, Ding HX, Leverett CA, Kyne RE, Liu KK, Fink SJ, O'Donnell CJ. Synthetic approaches to the 2014 new drugs. Bioorganic & Medicinal Chemistry. PMID 27020685 DOI: 10.1016/j.bmc.2016.03.004  0.828
2015 Ding HX, Leverett CA, Kyne RE, Liu KK, Fink SJ, Flick AC, O'Donnell CJ. Synthetic approaches to the 2013 new drugs. Bioorganic & Medicinal Chemistry. 23: 1895-922. PMID 25797159 DOI: 10.1016/J.Bmc.2015.02.056  0.828
2014 Ding HX, Leverett CA, Kyne RE, Liu KKC, Sakya SM, Flick AC, O'Donnell CJ. Synthetic approaches to the 2012 new drugs Bioorganic and Medicinal Chemistry. 22: 2005-2032. PMID 24629448 DOI: 10.1016/J.Bmc.2014.02.017  0.83
2013 Ding HX, Liu KK, Sakya SM, Flick AC, O'Donnell CJ. Synthetic approaches to the 2011 new drugs. Bioorganic & Medicinal Chemistry. 21: 2795-825. PMID 23623674 DOI: 10.1016/j.bmc.2013.02.061  0.699
2013 Flick AC, Padwa A. 2,3-Bis(phenylsulfonyl)-1,3-butadiene-mediated syntheses of piperidone derivatives Journal of Sulfur Chemistry. 34: 88-103. DOI: 10.1080/17415993.2012.704922  0.357
2013 Flick AC, Padwa A. Use of 2,3-bis (phenylsulfonyl)-1,3-butadiene as a reagent for the synthesis of azapolycyclic ring systems Journal of Sulfur Chemistry. 34: 7-16. DOI: 10.1080/17415993.2012.695793  0.399
2013 Padwa A, Flick AC. Intramolecular diels-alder cycloaddition of furans (IMDAF) for natural product synthesis Advances in Heterocyclic Chemistry. 110: 1-41. DOI: 10.1016/B978-0-12-408100-0.00001-X  0.385
2013 Flick AC, Padwa A. ChemInform Abstract: 2,3-Bis(phenylsulfonyl)-1,3-butadiene-mediated Syntheses of Piperidone Derivatives Cheminform. 44: no-no. DOI: 10.1002/chin.201315246  0.364
2012 Liu KK, Sakya SM, O'Donnell CJ, Flick AC, Ding HX. Synthetic approaches to the 2010 new drugs. Bioorganic & Medicinal Chemistry. 20: 1155-74. PMID 22261026 DOI: 10.1016/j.bmc.2011.12.049  0.699
2011 Liu KK, Sakya SM, O'Donnell CJ, Flick AC, Li J. Synthetic approaches to the 2009 new drugs. Bioorganic & Medicinal Chemistry. 19: 1136-54. PMID 21256756 DOI: 10.1016/j.bmc.2010.12.038  0.672
2011 Flick AC, Padwa A. A conjugate addition-dipolar cycloaddition approach towards the synthesis of various alkaloids Arkivoc. 2011: 137-161. DOI: 10.3998/Ark.5550190.0012.612  0.53
2010 Flick AC, Caballero MJ, Lee HI, Padwa A. 2,3-Bis(phenylsulfonyl)-1,3-butadiene as a reagent for the synthesis of the azatricyclic core of (+/-)-halichlorine. The Journal of Organic Chemistry. 75: 1992-6. PMID 20151655 DOI: 10.1021/Jo100055U  0.488
2010 Flick AC, Arevalo Caballero MJ, Padwa A. A conjugate addition/dipolar-cycloaddition cascade sequence for the synthesis of (±)-cylindricine C Tetrahedron. 66: 3643-3650. DOI: 10.1016/J.Tet.2010.03.088  0.446
2010 Flick AC, Caballero MJA, Lee HI, Padwa A. ChemInform Abstract: 2,3-Bis(phenylsulfonyl)-1,3-butadiene as a Reagent for the Synthesis of the Azatricyclic Core (IX) of (.+-.)-Halichlorine. Cheminform. 41: no-no. DOI: 10.1002/chin.201027147  0.394
2009 Bobeck DR, Lee HI, Flick AC, Padwa A. Application of cross-conjugated heteroaromatic betaines to the synthesis of the schizozygane alkaloid (+/-)-strempeliopine. The Journal of Organic Chemistry. 74: 7389-402. PMID 19711927 DOI: 10.1021/jo901336z  0.428
2009 Flick AC, Padwa A. A high yielding oxidation method for the preparation of substituted 2,3-dihydro-4-pyridones from 4-piperidones Arkivoc. 2009: 4-14. DOI: 10.3998/Ark.5550190.0010.602  0.408
2008 Flick AC, Caballero MJ, Padwa A. Utilization of a Michael addition: dipolar cycloaddition cascade for the synthesis of (+/-)-cylindricine C. Organic Letters. 10: 1871-4. PMID 18399653 DOI: 10.1021/Ol8006056  0.497
2008 Flick AC, Padwa A. A new route to heterocyclic compounds by the mercuric acetate oxidation of N-alkyl substituted 4-piperidones Tetrahedron Letters. 49: 5739-5741. DOI: 10.1016/J.Tetlet.2008.07.109  0.473
2005 Padwa A, Flick AC, Lee HI. An approach to the isoschizozygane alkaloid core using a 1,4-dipolar cycloaddition of a cross-conjugated heteroaromatic betaine. Organic Letters. 7: 2925-8. PMID 15987171 DOI: 10.1021/ol0508779  0.442
2004 Padwa A, Flick AC, Leverett CA, Stengel T. Rhodium(II)-catalyzed aziridination of allyl-substituted sulfonamides and carbamates. The Journal of Organic Chemistry. 69: 6377-86. PMID 15357598 DOI: 10.1021/Jo048990K  0.668
Low-probability matches (unlikely to be authored by this person)
2020 Fensome A, Ambler CM, Arnold E, Banker ME, Clark JD, Dowty ME, Efremov IV, Flick A, Gerstenberger BS, Gifford RS, Gopalsamy A, Hegen M, Jussif J, Limburg DC, Lin TH, et al. Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1. Bioorganic & Medicinal Chemistry. 115481. PMID 32253095 DOI: 10.1016/j.bmc.2020.115481  0.274
2017 Denny RA, Flick AC, Coe JW, Langille J, Basak A, Liu S, Stock IA, Sahasrabudhe P, Bonin PD, Hay DA, Brennan PE, Pletcher MT, Jones LH, Chekler EL. Structure-based design of highly selective inhibitors of the CREB binding protein bromodomain. Journal of Medicinal Chemistry. PMID 28375629 DOI: 10.1021/Acs.Jmedchem.6B01839  0.269
2021 Casimiro-Garcia A, Allais C, Brennan A, Choi C, Dower G, Farley KA, Fleming M, Flick A, Frisbie RK, Hall J, Hepworth D, Jones H, Knafels JD, Kortum S, Lovering FE, et al. Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1. Journal of Medicinal Chemistry. PMID 34967602 DOI: 10.1021/acs.jmedchem.1c01849  0.233
2015 Hett EC, Piatnitski Chekler EL, Basak A, Bonin PD, Denny RA, Flick AC, Geoghegan KF, Liu S, Pletcher MT, Sahasrabudhe P, Salter SC, Stock IA, Taylor AP, Jones LH. Direct photocapture of bromodomains using tropolone chemical probes Medchemcomm. 6: 1018-1023. DOI: 10.1039/C5Md00070J  0.22
2012 Sakya SM, Flick AC, Coe JW, Gray DL, Liang S, Ferri F, Van Den Berg M, Pouwer K. Synthesis of 4-azepanones and heteroaromatic-fused azepines Tetrahedron Letters. 53: 723-725. DOI: 10.1016/j.tetlet.2011.11.129  0.203
2015 Nuhant P, Allais C, Chen MZ, Coe JW, Dermenci A, Fadeyi OO, Flick AC, Mousseau JJ. Access to Highly Substituted 7-Azaindoles from 2-Fluoropyridines via 7-Azaindoline Intermediates. Organic Letters. PMID 26290951 DOI: 10.1021/Acs.Orglett.5B02098  0.182
2018 Schnute ME, Wennerstål M, Alley J, Bengtsson M, Blinn JR, Bolten CW, Braden T, Bonn T, Carlsson B, Caspers NL, Chen MZ, Choi C, Collis LP, Crouse K, F Auml Rneg Aring Rdh M, ... ... Flick A, et al. Discovery of 3-Cyano-N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide. A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 (RORC2) Inverse Agonist. Journal of Medicinal Chemistry. PMID 30130103 DOI: 10.1021/Acs.Jmedchem.8B00392  0.143
2013 Robinson RP, Casimiro-Garcia A, Liang S, Anderson DP, Flick AC. A tandem hetero Diels-Alder/Mannich approach for the synthesis of a versatile hexahydro-2H-pyrano[3,2-c]pyridin-4(3H)-one core Tetrahedron Letters. 54: 6168-6170. DOI: 10.1016/j.tetlet.2013.08.105  0.14
2015 Schmitt DC, Taylor AP, Flick AC, Kyne RE. Synthesis of pyrazoles from 1,3-diols via hydrogen transfer catalysis. Organic Letters. 17: 1405-8. PMID 25719568 DOI: 10.1021/Acs.Orglett.5B00266  0.137
2023 Schnute ME, Trujillo JI, Lee KL, Unwalla R, Vajdos FF, Kauppi B, Nuhant P, Flick AC, Crouse KK, Zhao Y, Samuel A, Lombardo V, Taylor AP, Brault AL, Knafels JD, et al. Macrocyclic Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonists. Acs Medicinal Chemistry Letters. 14: 191-198. PMID 36793423 DOI: 10.1021/acsmedchemlett.2c00500  0.126
2018 Fensome A, Ambler CM, Arnold E, Banker ME, Brown MF, Chrencik J, Clark JD, Dowty ME, Efremov IV, Flick A, Gerstenberger BS, Gopalsamy A, Hayward MM, Hegen M, Hollingshead BD, et al. Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841). Journal of Medicinal Chemistry. PMID 30113844 DOI: 10.1021/acs.jmedchem.8b00917  0.117
2016 Chen MZ, Sach NW, Nuhant P, Fadeyi OO, Trujillo J, Lombardo V, Bernier L, Unwalla R, Flick AC. Synthesis of (R)- and (S)-α-trifluoromethyl propanoic acids via asymmetric hydrogenation followed by salt resolution Tetrahedron Asymmetry. 27: 882-887. DOI: 10.1016/J.Tetasy.2016.07.004  0.116
2015 Chekler EL, Pellegrino JA, Lanz TA, Denny RA, Flick AC, Coe J, Langille J, Basak A, Liu S, Stock IA, Sahasrabudhe P, Bonin PD, Lee K, Pletcher MT, Jones LH. Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities. Chemistry & Biology. PMID 26670081 DOI: 10.1016/j.chembiol.2015.10.013  0.103
2007 Zapata-Castillo PY, Flick AC, López-Puc G, Solís-Ruiz A, Barahona-Pérez F, Santana-Buzzy N, Iglesias-Andreu L. Somatic embryogenesis in Habanero pepper (C. chinense Jacq.) from cell suspensions Hortscience. 42: 329-333.  0.022
2021 Santa-Martinez E, Cardoso Castro C, Flick A, Sullivan M, Riday H, Clayton MK, Brunet J. Bee species visiting Medicago sativa differ in pollen deposition curves with consequences for gene flow. American Journal of Botany. PMID 34114219 DOI: 10.1002/ajb2.1683  0.013
2011 Coe JW, Brooks PR, Vetelino MG, Bashore CG, Bianco K, Flick AC. Syntheses of the opioid substructures 1,2,3,4,5,6-hexahydro-2,6-methano-3- benzazocine and 2,3,4,5-tetrahydro-1,5-methano-1H-2-benzazepine Tetrahedron Letters. 52: 953-954. DOI: 10.1016/j.tetlet.2010.12.072  0.01
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