Guojun Bu - Publications

Affiliations: 
Biology & Biomedical Sciences (Molecular Cell Biology) Washington University, Saint Louis, St. Louis, MO 
Area:
Cell Biology, Molecular Biology

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Year Citation  Score
2024 Shue F, White LJ, Hendrix R, Ulrich J, Henson RL, Knight W, Martens YA, Wang N, Roy B, Starling SC, Ren Y, Xiong C, Asmann YW, Syrjanen JA, Vassilaki M, ... ... Bu G, et al. CSF biomarkers of immune activation and Alzheimer's disease for predicting cognitive impairment risk in the elderly. Science Advances. 10: eadk3674. PMID 38569027 DOI: 10.1126/sciadv.adk3674  0.747
2024 Raulin AC, Doss SV, Heckman MG, Craver EC, Li Z, Ikezu TC, Sekiya H, Liu CC, Martens YA, Rosenberg CL, Kuchenbecker LA, DeTure M, Reichard RR, Nguyen AT, Constantopoulos E, ... ... Bu G, et al. Impact of APOE on amyloid and tau accumulation in argyrophilic grain disease and Alzheimer's disease. Acta Neuropathologica Communications. 12: 25. PMID 38336940 DOI: 10.1186/s40478-024-01731-0  0.59
2023 Liu CC, Wang N, Chen Y, Inoue Y, Shue F, Ren Y, Wang M, Qiao W, Ikezu TC, Li Z, Zhao J, Martens Y, Doss SV, Rosenberg CL, Jeevaratnam S, ... ... Bu G, et al. Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer's disease. Nature Immunology. PMID 37857825 DOI: 10.1038/s41590-023-01640-9  0.828
2023 Zhao J, Ikezu TC, Lu W, Macyczko JR, Li Y, Lewis-Tuffin LJ, Martens YA, Ren Y, Zhu Y, Asmann YW, Ertekin-Taner N, Kanekiyo T, Bu G. APOE deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoids. Stem Cell Research & Therapy. 14: 214. PMID 37605285 DOI: 10.1186/s13287-023-03444-y  0.332
2023 Macyczko JR, Wang N, Lu W, Jeevaratnam S, Shue F, Martens Y, Liu CC, Kanekiyo T, Bu G, Li Y. Upregulation of sFRP1 Is More Profound in Female than Male 5xFAD Mice and Positively Associated with Amyloid Pathology. Journal of Alzheimer's Disease : Jad. PMID 37545238 DOI: 10.3233/JAD-230218  0.775
2023 Wang W, Li Y, Ma F, Sheng X, Chen K, Zhuo R, Wang C, Zheng H, Zhang YW, Bu G, Chen XF, Zhong L. Microglial repopulation reverses cognitive and synaptic deficits in an Alzheimer's disease model by restoring BDNF signaling. Brain, Behavior, and Immunity. PMID 37482204 DOI: 10.1016/j.bbi.2023.07.011  0.35
2023 Zhong L, Sheng X, Wang W, Li Y, Zhuo R, Wang K, Zhang L, Hu DD, Hong Y, Chen L, Rao H, Li T, Chen M, Lin Z, Zhang YW, ... ... Bu G, et al. TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration. Immunity. PMID 37442133 DOI: 10.1016/j.immuni.2023.06.016  0.356
2023 Inoue Y, Shue F, Bu G, Kanekiyo T. Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer's disease. Molecular Neurodegeneration. 18: 46. PMID 37434208 DOI: 10.1186/s13024-023-00640-5  0.75
2023 Cerneckis J, Bu G, Shi Y. Pushing the boundaries of brain organoids to study Alzheimer's disease. Trends in Molecular Medicine. 29: 659-672. PMID 37353408 DOI: 10.1016/j.molmed.2023.05.007  0.357
2023 Guo L, Cao J, Hou J, Li Y, Huang M, Zhu L, Zhang L, Lee Y, Duarte ML, Zhou X, Wang M, Liu CC, Martens Y, Chao M, Goate A, ... Bu G, et al. Sex specific molecular networks and key drivers of Alzheimer's disease. Molecular Neurodegeneration. 18: 39. PMID 37340466 DOI: 10.1186/s13024-023-00624-5  0.549
2023 Qiao W, Chen Y, Zhong J, Madden BJ, Charlesworth CM, Martens YA, Liu CC, Knight J, Ikezu TC, Aishe K, Zhu Y, Meneses A, Rosenberg CL, Kuchenbecker LA, Vanmaele LK, ... ... Bu G, et al. Correction: Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology. Molecular Neurodegeneration. 18: 28. PMID 37118783 DOI: 10.1186/s13024-023-00603-w  0.777
2023 Oue H, Yamazaki Y, Qiao W, Yuanxin C, Ren Y, Kurti A, Shue F, Parsons TM, Perkerson RB, Kawatani K, Wang N, Starling SC, Roy B, Mosneag IE, Aikawa T, ... ... Bu G, et al. LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4. Jci Insight. 8. PMID 37036005 DOI: 10.1172/jci.insight.163822  0.808
2023 Qiao W, Chen Y, Zhong J, Madden BJ, Charlesworth CM, Martens YA, Liu CC, Knight J, Ikezu TC, Aishe K, Zhu Y, Meneses A, Rosenberg CL, Kuchenbecker LA, Vanmaele LK, ... ... Bu G, et al. Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology. Molecular Neurodegeneration. 18: 8. PMID 36721205 DOI: 10.1186/s13024-023-00599-3  0.808
2023 Oatman SR, Reddy JS, Quicksall Z, Carrasquillo MM, Wang X, Liu CC, Yamazaki Y, Nguyen TT, Malphrus K, Heckman M, Biswas K, Nho K, Baker M, Martens YA, Zhao N, ... ... Bu G, et al. Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer's disease related proteins. Molecular Neurodegeneration. 18: 2. PMID 36609403 DOI: 10.1186/s13024-022-00592-2  0.612
2023 Raulin AC, Liu CC, Bu G. An assay to evaluate the capacity of cholesterol acceptors using BODIPY-cholesterol in cells. Star Protocols. 4: 101976. PMID 36598853 DOI: 10.1016/j.xpro.2022.101976  0.469
2022 Meneses AD, Koga S, Li Z, O'Leary J, Li F, Chen K, Murakami A, Qiao W, Kurti A, Heckman MG, White L, Xie M, Chen Y, Finch NA, Lim MJ, ... ... Bu G, et al. APOE2 Exacerbates TDP-43 Related Toxicity in the Absence of Alzheimer Pathology. Annals of Neurology. PMID 36546684 DOI: 10.1002/ana.26580  0.35
2022 Wang N, Wang M, Jeevaratnam S, Rosenberg C, Ikezu TC, Shue F, Doss SV, Alnobani A, Martens YA, Wren M, Asmann YW, Zhang B, Bu G, Liu CC. Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination. Molecular Neurodegeneration. 17: 75. PMID 36419137 DOI: 10.1186/s13024-022-00577-1  0.777
2022 Raulin AC, Doss SV, Trottier ZA, Ikezu TC, Bu G, Liu CC. ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies. Molecular Neurodegeneration. 17: 72. PMID 36348357 DOI: 10.1186/s13024-022-00574-4  0.617
2022 Macyczko JR, Wang N, Zhao J, Ren Y, Lu W, Ikezu TC, Zhao N, Liu CC, Bu G, Li Y. Suppression of Wnt/β-Catenin Signaling Is Associated with Downregulation of Wnt1, PORCN, and Rspo2 in Alzheimer's Disease. Molecular Neurobiology. PMID 36215026 DOI: 10.1007/s12035-022-03065-1  0.564
2022 Zhao N, Qiao W, Li F, Ren Y, Zheng J, Martens YA, Wang X, Li L, Liu CC, Chen K, Zhu Y, Ikezu TC, Li Z, Meneses AD, Jin Y, ... ... Bu G, et al. Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia. The Journal of Experimental Medicine. 219. PMID 36107206 DOI: 10.1084/jem.20212479  0.587
2022 Chen K, Martens YA, Meneses A, Ryu DH, Lu W, Raulin AC, Li F, Zhao J, Chen Y, Jin Y, Linares C, Goodwin M, Li Y, Liu CC, Kanekiyo T, ... ... Bu G, et al. LRP1 is a neuronal receptor for α-synuclein uptake and spread. Molecular Neurodegeneration. 17: 57. PMID 36056345 DOI: 10.1186/s13024-022-00560-w  0.514
2022 Liu CC, Zhao J, Fu Y, Inoue Y, Ren Y, Chen Y, Doss SV, Shue F, Jeevaratnam S, Bastea L, Wang N, Martens YA, Qiao W, Wang M, Zhao N, ... ... Bu G, et al. Peripheral apoE4 enhances Alzheimer's pathology and impairs cognition by compromising cerebrovascular function. Nature Neuroscience. 25: 1020-1033. PMID 35915180 DOI: 10.1038/s41593-022-01127-0  0.809
2022 Jin Y, Li F, Sonoustoun B, Kondru NC, Martens YA, Qiao W, Heckman MG, Ikezu TC, Li Z, Burgess JD, Amerna D, O'Leary J, DeTure MA, Zhao J, McLean PJ, ... ... Bu G, et al. APOE4 exacerbates α-synuclein seeding activity and contributes to neurotoxicity in Alzheimer's disease with Lewy body pathology. Acta Neuropathologica. PMID 35471463 DOI: 10.1007/s00401-022-02421-8  0.316
2022 Li Y, Macyczko JR, Liu CC, Bu G. ApoE4 reduction: An emerging and promising therapeutic strategy for Alzheimer's disease. Neurobiology of Aging. 115: 20-28. PMID 35453035 DOI: 10.1016/j.neurobiolaging.2022.03.011  0.622
2022 Li Z, Heckman MG, Kanekiyo T, Martens YA, Day GS, Vassilaki M, Liu CC, Bennett DA, Petersen RC, Zhao N, Bu G. Clinicopathologic Factors Associated With Reversion to Normal Cognition in Patients With Mild Cognitive Impairment. Neurology. PMID 35314499 DOI: 10.1212/WNL.0000000000200387  0.42
2022 Martens YA, Zhao N, Liu CC, Kanekiyo T, Yang AJ, Goate AM, Holtzman DM, Bu G. ApoE Cascade Hypothesis in the pathogenesis of Alzheimer's disease and related dementias. Neuron. PMID 35298921 DOI: 10.1016/j.neuron.2022.03.004  0.569
2021 Meneses A, Koga S, O'Leary J, Dickson DW, Bu G, Zhao N. TDP-43 Pathology in Alzheimer's Disease. Molecular Neurodegeneration. 16: 84. PMID 34930382 DOI: 10.1186/s13024-021-00503-x  0.364
2021 Xie M, Liu YU, Zhao S, Zhang L, Bosco DB, Pang YP, Zhong J, Sheth U, Martens YA, Zhao N, Liu CC, Zhuang Y, Wang L, Dickson DW, Mattson MP, ... Bu G, et al. TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration. Nature Neuroscience. PMID 34916658 DOI: 10.1038/s41593-021-00975-6  0.528
2021 Sheng X, Yao Y, Huang R, Xu Y, Zhu Y, Chen L, Zhang L, Wang W, Zhuo R, Can D, Chang CF, Zhang YW, Xu H, Bu G, Zhong L, et al. Identification of the minimal active soluble TREM2 sequence for modulating microglial phenotypes and amyloid pathology. Journal of Neuroinflammation. 18: 286. PMID 34893068 DOI: 10.1186/s12974-021-02340-7  0.385
2021 Zhao J, Lu W, Ren Y, Fu Y, Martens YA, Shue F, Davis MD, Wang X, Chen K, Li F, Liu CC, Graff-Radford NR, Wszolek ZK, Younkin SG, Brafman DA, ... ... Bu G, et al. Correction to: Apolipoprotein E regulates lipid metabolism and α‑synuclein pathology in human iPSC‑derived cerebral organoids. Acta Neuropathologica. PMID 34724591 DOI: 10.1007/s00401-021-02380-6  0.761
2021 Liu CC, Murray ME, Li X, Zhao N, Wang N, Heckman MG, Shue F, Martens Y, Li Y, Raulin AC, Rosenberg CL, Doss SV, Zhao J, Wren MC, Jia L, ... ... Bu G, et al. -Jacksonville (V236E) variant reduces self-aggregation and risk of dementia. Science Translational Medicine. 13: eabc9375. PMID 34586832 DOI: 10.1126/scitranslmed.abc9375  0.754
2021 Zhao J, Lu W, Ren Y, Fu Y, Martens YA, Shue F, Davis MD, Wang X, Chen K, Li F, Liu CC, Graff-Radford NR, Wszolek ZK, Younkin SG, Brafman DA, ... ... Bu G, et al. Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids. Acta Neuropathologica. PMID 34453582 DOI: 10.1007/s00401-021-02361-9  0.801
2021 Yamazaki A, Shue F, Yamazaki Y, Martens YA, Bu G, Liu CC. Preparation of single cell suspensions enriched in mouse brain vascular cells for single-cell RNA sequencing. Star Protocols. 2: 100715. PMID 34401781 DOI: 10.1016/j.xpro.2021.100715  0.757
2021 Martens YA, Xu S, Tait R, Li G, Zhao XC, Lu W, Liu CC, Kanekiyo T, Bu G, Zhao J. Generation and validation of knockout human iPSC-derived cerebral organoids. Star Protocols. 2: 100571. PMID 34151296 DOI: 10.1016/j.xpro.2021.100571  0.566
2021 Reddy JS, Allen M, Ho CCG, Oatman SR, İş Ö, Quicksall ZS, Wang X, Jin J, Patel TA, Carnwath TP, Nguyen TT, Malphrus KG, Lincoln SJ, Carrasquillo MM, Crook JE, ... ... Bu G, et al. Genome-wide analysis identifies a novel LINC-PINT splice variant associated with vascular amyloid pathology in Alzheimer's disease. Acta Neuropathologica Communications. 9: 93. PMID 34020725 DOI: 10.1186/s40478-021-01199-2  0.346
2021 Zhao J, Fu Y, Yamazaki Y, Ren Y, Davis MD, Liu CC, Lu W, Wang X, Chen K, Cherukuri Y, Jia L, Martens YA, Job L, Shue F, Nguyen TT, ... ... Bu G, et al. Author Correction: APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids. Nature Communications. 12: 2707. PMID 33953196 DOI: 10.1038/s41467-021-23081-4  0.773
2020 Yamazaki Y, Liu CC, Yamazaki A, Shue F, Martens YA, Chen Y, Qiao W, Kurti A, Oue H, Ren Y, Li Y, Aikawa T, Cherukuri Y, Fryer JD, Asmann YW, ... ... Bu G, et al. Vascular ApoE4 Impairs Behavior by Modulating Gliovascular Function. Neuron. PMID 33321072 DOI: 10.1016/j.neuron.2020.11.019  0.799
2020 Wojtas AM, Sens JP, Kang SS, Baker KE, Berry TJ, Kurti A, Daughrity L, Jansen-West KR, Dickson DW, Petrucelli L, Bu G, Liu CC, Fryer JD. Astrocyte-derived clusterin suppresses amyloid formation in vivo. Molecular Neurodegeneration. 15: 71. PMID 33246484 DOI: 10.1186/s13024-020-00416-1  0.61
2020 Li Z, Shue F, Zhao N, Shinohara M, Bu G. APOE2: protective mechanism and therapeutic implications for Alzheimer's disease. Molecular Neurodegeneration. 15: 63. PMID 33148290 DOI: 10.1186/s13024-020-00413-4  0.778
2020 Zhao J, Fu Y, Yamazaki Y, Ren Y, Davis MD, Liu CC, Lu W, Wang X, Chen K, Cherukuri Y, Jia L, Martens YA, Job L, Shue F, Nguyen TT, ... ... Bu G, et al. APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids. Nature Communications. 11: 5540. PMID 33139712 DOI: 10.1038/s41467-020-19264-0  0.804
2020 Hou X, Watzlawik JO, Cook C, Liu CC, Kang SS, Lin WL, DeTure M, Heckman MG, Diehl NN, Al-Shaikh FSH, Walton RL, Ross OA, Melrose HL, Ertekin-Taner N, Bu G, et al. Mitophagy alterations in Alzheimer's disease are associated with granulovacuolar degeneration and early tau pathology. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 33090691 DOI: 10.1002/alz.12198  0.55
2020 Shinohara M, Kanekiyo T, Tachibana M, Kurti A, Shinohara M, Fu Y, Zhao J, Han X, Sullivan PM, Rebeck GW, Fryer JD, Heckman MG, Bu G. is associated with longevity independent of Alzheimer's disease. Elife. 9. PMID 33074098 DOI: 10.7554/eLife.62199  0.338
2020 Liu CC, Yamazaki Y, Heckman MG, Martens YA, Jia L, Yamazaki A, Diehl NN, Zhao J, Zhao N, DeTure M, Davis MD, Felton LM, Qiao W, Li Y, Li H, ... ... Bu G, et al. Tau and apolipoprotein E modulate cerebrovascular tight junction integrity independent of cerebral amyloid angiopathy in Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 32827351 DOI: 10.1002/Alz.12104  0.634
2020 Carare RO, Aldea R, Agarwal N, Bacskai BJ, Bechman I, Boche D, Bu G, Bulters D, Clemens A, Counts SE, de Leon M, Eide PK, Fossati S, Greenberg SM, Hamel E, et al. Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12053. PMID 32775596 DOI: 10.1002/Dad2.12053  0.422
2020 Zhou X, Brooks M, Jiang P, Koga S, Zuberi AR, Baker MC, Parsons TM, Castanedes-Casey M, Phillips V, Librero AL, Kurti A, Fryer JD, Bu G, Lutz C, Dickson DW, et al. Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin-deficient mice. Embo Reports. e50197. PMID 32761777 DOI: 10.15252/Embr.202050197  0.329
2020 Caselli RJ, Knopman DS, Bu G. An agnostic reevaluation of the amyloid cascade hypothesis of Alzheimer's disease pathogenesis: The role of APP homeostasis. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 32588983 DOI: 10.1002/Alz.12124  0.468
2020 Zhou X, Nicholson AM, Ren Y, Brooks M, Jiang P, Zuberi A, Phuoc HN, Perkerson RB, Matchett B, Parsons TM, Finch NA, Lin W, Qiao W, Castanedes-Casey M, Phillips V, ... ... Bu G, et al. Loss of TMEM106B leads to myelination deficits: implications for frontotemporal dementia treatment strategies. Brain : a Journal of Neurology. PMID 32504082 DOI: 10.1093/Brain/Awaa141  0.35
2020 Shinohara M, Tashiro Y, Suzuki K, Fukumori A, Bu G, Sato N. Interaction between genotype and diabetes in cognitive decline. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12006. PMID 32211501 DOI: 10.1002/Dad2.12006  0.341
2020 Zhao N, Ren Y, Yamazaki Y, Qiao W, Li F, Felton LM, Mahmoudiandehkordi S, Kueider-Paisley A, Sonoustoun B, Arnold M, Shue F, Zheng J, Attrebi ON, Martens YA, Li Z, ... ... Bu G, et al. Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways. Neuron. PMID 32199103 DOI: 10.1016/J.Neuron.2020.02.034  0.807
2020 Zhao N, Attrebi ON, Ren Y, Qiao W, Sonustun B, Martens YA, Meneses AD, Li F, Shue F, Zheng J, Van Ingelgom AJ, Davis MD, Kurti A, Knight JA, Linares C, ... ... Bu G, et al. APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid. Science Translational Medicine. 12. PMID 32024798 DOI: 10.1126/Scitranslmed.Aay1809  0.807
2019 Zhou J, Chow HM, Liu Y, Wu D, Shi M, Li J, Wen L, Gao Y, Chen G, Zhuang K, Lin H, Zhang G, Xie W, Li H, Leng L, ... ... Bu G, et al. Cyclin-Dependent Kinase 5-Dependent BAG3 Degradation Modulates Synaptic Protein Turnover. Biological Psychiatry. PMID 31955914 DOI: 10.1016/J.Biopsych.2019.11.013  0.331
2019 Aikawa T, Ren Y, Yamazaki Y, Tachibana M, Johnson MR, Anderson CT, Martens YA, Holm ML, Asmann YW, Saito T, Saido TC, Fitzgerald ML, Bu G, Kanekiyo T. ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain. Proceedings of the National Academy of Sciences of the United States of America. PMID 31690660 DOI: 10.1073/Pnas.1908529116  0.452
2019 Yamazaki Y, Shinohara M, Yamazaki A, Ren Y, Asmann YW, Kanekiyo T, Bu G. ApoE (Apolipoprotein E) in Brain Pericytes Regulates Endothelial Function in an Isoform-Dependent Manner by Modulating Basement Membrane Components. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA119313169. PMID 31665905 DOI: 10.1161/Atvbaha.119.313169  0.452
2019 Yamazaki Y, Zhao N, Caulfield TR, Liu CC, Bu G. Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies. Nature Reviews. Neurology. PMID 31367008 DOI: 10.1038/S41582-019-0228-7  0.656
2019 Zhao S, Li Z, Zhang M, Zhang L, Zheng H, Ning J, Wang Y, Wang F, Zhang X, Gan H, Wang Y, Zhang X, Luo H, Bu G, Xu H, et al. A brain somatic RHEB doublet mutation causes focal cortical dysplasia type II. Experimental & Molecular Medicine. 51: 84. PMID 31337748 DOI: 10.1038/S12276-019-0277-4  0.319
2019 Zhong L, Xu Y, Zhuo R, Wang T, Wang K, Huang R, Wang D, Gao Y, Zhu Y, Sheng X, Chen K, Wang N, Zhu L, Can D, Marten Y, ... ... Bu G, et al. Author Correction: Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model. Nature Communications. 10: 2923. PMID 31266955 DOI: 10.1038/S41467-019-10950-2  0.473
2019 Shinohara M, Shinohara M, Zhao J, Fu Y, Liu CC, Kanekiyo T, Bu G. 5-HT3 Antagonist Ondansetron Increases apoE Secretion by Modulating the LXR-ABCA1 Pathway. International Journal of Molecular Sciences. 20. PMID 30934555 DOI: 10.3390/Ijms20061488  0.612
2019 Zhong L, Xu Y, Zhuo R, Wang T, Wang K, Huang R, Wang D, Gao Y, Zhu Y, Sheng X, Chen K, Wang N, Zhu L, Can D, Marten Y, ... ... Bu G, et al. Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model. Nature Communications. 10: 1365. PMID 30911003 DOI: 10.1038/S41467-019-09118-9  0.675
2019 Yamazaki Y, Shinohara M, Shinohara M, Yamazaki A, Murray ME, Liesinger AM, Heckman MG, Lesser ER, Parisi JE, Petersen RC, Dickson DW, Kanekiyo T, Bu G. Selective loss of cortical endothelial tight junction proteins during Alzheimer's disease progression. Brain : a Journal of Neurology. PMID 30770921 DOI: 10.1093/Brain/Awz011  0.451
2019 Tachibana M, Holm ML, Liu CC, Shinohara M, Aikawa T, Oue H, Yamazaki Y, Martens YA, Murray ME, Sullivan PM, Weyer K, Glerup S, Dickson DW, Bu G, Kanekiyo T. APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1. The Journal of Clinical Investigation. PMID 30741718 DOI: 10.1172/Jci124853  0.632
2019 Allen M, Reddy JS, Carrasquillo MM, Wang X, Lincoln SJ, Nguyen T, Malphrus KG, Asmann YW, Murray ME, Bu G, Dickson DW, Ertekin-Taner N. INTEGRATIVE GENOMIC PROFILING TO IDENTIFY GENES AND PATHWAYS ASSOCIATED WITH VASCULAR RISK IN AD Alzheimer's & Dementia. 15: P1617. DOI: 10.1016/J.Jalz.2019.06.4843  0.332
2018 Twohig D, Rodriguez-Vieitez E, Sando SB, Berge G, Lauridsen C, Møller I, Grøntvedt GR, Bråthen G, Patra K, Bu G, Benzinger TLS, Karch CM, Fagan A, Morris JC, Bateman RJ, et al. The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer's disease. Acta Neuropathologica Communications. 6: 130. PMID 30477568 DOI: 10.1186/S40478-018-0624-Z  0.429
2018 Zhao N, Liu CC, Van Ingelgom AJ, Linares C, Kurti A, Knight JA, Heckman MG, Diehl NN, Shinohara M, Martens YA, Attrebi ON, Petrucelli L, Fryer JD, Wszolek ZK, Graff-Radford NR, ... ... Bu G, et al. APOE ε2 is associated with increased tau pathology in primary tauopathy. Nature Communications. 9: 4388. PMID 30348994 DOI: 10.1038/S41467-018-06783-0  0.625
2018 Zhao D, Meng J, Zhao Y, Huo Y, Liu Y, Zheng N, Zhang M, Gao Y, Chen Z, Sun H, Wang X, Jing C, Zhang T, Zhang X, Luo H, ... ... Bu G, et al. RPS23RG1 Is Required for Synaptic Integrity and Rescues Alzheimer's Disease-Associated Cognitive Deficits. Biological Psychiatry. PMID 30292394 DOI: 10.1016/J.Biopsych.2018.08.009  0.39
2018 Dickson DW, Heckman MG, Murray ME, Soto AI, Walton RL, Diehl NN, van Gerpen JA, Uitti RJ, Wszolek ZK, Ertekin-Taner N, Knopman DS, Petersen RC, Graff-Radford NR, Boeve BF, Bu G, et al. ε4 is associated with severity of Lewy body pathology independent of Alzheimer pathology. Neurology. PMID 30143564 DOI: 10.1212/Wnl.0000000000006212  0.4
2018 Hettinger JC, Lee H, Bu G, Holtzman DM, Cirrito JR. AMPA-ergic regulation of amyloid-β levels in an Alzheimer's disease mouse model. Molecular Neurodegeneration. 13: 22. PMID 29764453 DOI: 10.1186/S13024-018-0256-6  0.463
2018 Zhong L, Wang Z, Wang D, Wang Z, Martens YA, Wu L, Xu Y, Wang K, Li J, Huang R, Can D, Xu H, Bu G, Chen XF. Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2). Molecular Neurodegeneration. 13: 15. PMID 29587871 DOI: 10.1186/S13024-018-0247-7  0.476
2018 Zhao Y, Wu X, Li X, Jiang LL, Gui X, Liu Y, Sun Y, Zhu B, Piña-Crespo JC, Zhang M, Zhang N, Chen X, Bu G, An Z, Huang TY, et al. TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function. Neuron. 97: 1023-1031.e7. PMID 29518356 DOI: 10.1016/J.Neuron.2018.01.031  0.504
2018 Yan Y, Song L, Bejoy J, Zhao J, Kanekiyo T, Bu G, Zhou Y, Li Y. Modelling Neurodegenerative Microenvironment Using Cortical Organoids Derived from Human Stem Cells. Tissue Engineering. Part A. PMID 29361890 DOI: 10.1089/Ten.Tea.2017.0423  0.323
2017 Zhao Y, Li X, Huang T, Jiang LL, Tan Z, Zhang M, Cheng IH, Wang X, Bu G, Zhang YW, Wang Q, Xu H. Intracellular trafficking of TREM2 is regulated by presenilin 1. Experimental & Molecular Medicine. 49: e405. PMID 29611543 DOI: 10.1038/Emm.2017.200  0.375
2017 Liu CC, Zhao N, Fu Y, Wang N, Linares C, Tsai CW, Bu G. ApoE4 Accelerates Early Seeding of Amyloid Pathology. Neuron. 96: 1024-1032.e3. PMID 29216449 DOI: 10.1016/J.Neuron.2017.11.013  0.609
2017 Tachibana M, Yamazaki Y, Liu CC, Bu G, Kanekiyo T. Pericyte implantation in the brain enhances cerebral blood flow and reduces amyloid-β pathology in amyloid model mice. Experimental Neurology. 300: 13-21. PMID 29106980 DOI: 10.1016/J.Expneurol.2017.10.023  0.613
2017 Kang SS, Kurti A, Baker KE, Liu CC, Colonna M, Ulrich JD, Holtzman DM, Bu G, Fryer JD. Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal. Human Molecular Genetics. PMID 29040522 DOI: 10.1093/Hmg/Ddx366  0.579
2017 Zhao N, Liu CC, Van Ingelgom AJ, Martens YA, Linares C, Knight JA, Painter MM, Sullivan PM, Bu G. Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes. Neuron. 96: 115-129.e5. PMID 28957663 DOI: 10.1016/J.Neuron.2017.09.003  0.53
2017 Wojtas AM, Kang SS, Olley BM, Gatherer M, Shinohara M, Lozano PA, Liu CC, Kurti A, Baker KE, Dickson DW, Yue M, Petrucelli L, Bu G, Carare RO, Fryer JD. Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways. Proceedings of the National Academy of Sciences of the United States of America. PMID 28701379 DOI: 10.1016/J.Jalz.2017.06.250  0.654
2017 Zhong L, Zhang ZL, Li X, Liao C, Mou P, Wang T, Wang Z, Wang Z, Wei M, Xu H, Bu G, Chen XF. TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway. Frontiers in Aging Neuroscience. 9: 204. PMID 28680398 DOI: 10.3389/Fnagi.2017.00204  0.366
2017 Zhao J, Davis MD, Atagi Y, Shinohara M, Graff-Radford NR, Younkin SG, Wszolek ZK, Kanekiyo T, Bu G. APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes. Human Molecular Genetics. PMID 28444230 DOI: 10.1093/Hmg/Ddx155  0.401
2017 Zhao N, Liu CC, Qiao W, Bu G. Apolipoprotein E, Receptors, and Modulation of Alzheimer's Disease. Biological Psychiatry. PMID 28434655 DOI: 10.1016/J.Biopsych.2017.03.003  0.63
2017 Shinohara M, Tachibana M, Kanekiyo T, Bu G. Role of LRP1 in the pathogenesis of Alzheimer's disease: evidence from clinical and preclinical studies. Journal of Lipid Research. PMID 28381441 DOI: 10.1194/Jlr.R075796  0.494
2017 Liu CC, Hu J, Zhao N, Wang J, Na W, Cirrito JR, Kanekiyo T, Holtzman DM, Bu G. Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28275161 DOI: 10.1523/Jneurosci.3442-16.2017  0.661
2017 Rogers JT, Liu CC, Zhao N, Wang J, Putzke T, Yang L, Shinohara M, Fryer JD, Kanekiyo T, Bu G. Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice. Neurobiology of Aging. 53: 112-121. PMID 28254590 DOI: 10.1016/J.Neurobiolaging.2017.02.001  0.452
2017 Zhong L, Chen XF, Wang T, Wang Z, Liao C, Wang Z, Huang R, Wang D, Li X, Wu L, Jia L, Zheng H, Painter M, Atagi Y, Liu CC, ... ... Bu G, et al. Soluble TREM2 induces inflammatory responses and enhances microglial survival. The Journal of Experimental Medicine. PMID 28209725 DOI: 10.1084/Jem.20160844  0.609
2017 Nielsen HM, Chen K, Lee W, Chen Y, Bauer RJ, Reiman E, Caselli R, Bu G. Peripheral apoE isoform levels in cognitively normal APOE ε3/ε4 individuals are associated with regional gray matter volume and cerebral glucose metabolism. Alzheimer's Research & Therapy. 9: 5. PMID 28137305 DOI: 10.1186/S13195-016-0231-9  0.422
2017 Zheng H, Jia L, Liu CC, Li Zhong ZR, Yang L, Chen XF, Fryer JD, Wang X, Zhang YW, Xu H, Bu G. TREM2 promotes microglial survival by activating Wnt/β-catenin pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28077724 DOI: 10.1523/Jneurosci.2459-16.2017  0.559
2016 Wang X, Zhou Y, Wang J, Tseng IC, Huang T, Zhao Y, Zheng Q, Gao Y, Luo H, Zhang X, Bu G, Hong W, Xu H. SNX27 Deletion Causes Hydrocephalus by Impairing Ependymal Cell Differentiation and Ciliogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 12586-12597. PMID 27974614 DOI: 10.1523/Jneurosci.1620-16.2016  0.371
2016 Yang L, Liu CC, Zheng H, Kanekiyo T, Atagi Y, Jia L, Wang D, N'songo A, Can D, Xu H, Chen XF, Bu G. LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways. Journal of Neuroinflammation. 13: 304. PMID 27931217 DOI: 10.1186/S12974-016-0772-7  0.629
2016 Cheng J, Guo X, Zhang T, Zhong L, Bu G, Chen X. TREMs in Alzheimer's disease: Genetic and clinical investigations. Clinica Chimica Acta; International Journal of Clinical Chemistry. 463: 88-95. PMID 27769848 DOI: 10.1016/j.cca.2016.10.022  0.353
2016 Pottier C, Ravenscroft TA, Brown PH, Finch NA, Baker M, Parsons M, Asmann YW, Ren Y, Christopher E, Levitch D, van Blitterswijk M, Cruchaga C, Campion D, Nicolas G, Richard AC, ... ... Bu G, et al. TYROBP genetic variants in early-onset Alzheimer's disease. Neurobiology of Aging. PMID 27658901 DOI: 10.1016/J.Neurobiolaging.2016.07.028  0.397
2016 Kang SS, Kurti A, Wojtas A, Baker KE, Liu CC, Kanekiyo T, Deming Y, Cruchaga C, Estus S, Bu G, Fryer JD. Identification of Plexin A4 as a novel Clusterin receptor links two Alzheimer's disease risk genes. Human Molecular Genetics. PMID 27378688 DOI: 10.1093/Hmg/Ddw188  0.632
2016 Nicholson AM, Finch NA, Almeida M, Perkerson RB, van Blitterswijk M, Wojtas A, Cenik B, Rotondo S, Inskeep V, Almasy L, Dyer T, Peralta J, Jun G, Wood AR, Frayling TM, ... ... Bu G, et al. Prosaposin is a regulator of progranulin levels and oligomerization. Nature Communications. 7: 11992. PMID 27356620 DOI: 10.1038/Ncomms11992  0.364
2016 Yamazaki Y, Painter MM, Bu G, Kanekiyo T. Apolipoprotein E as a Therapeutic Target in Alzheimer's Disease: A Review of Basic Research and Clinical Evidence. Cns Drugs. PMID 27328687 DOI: 10.1007/s40263-016-0361-4  0.359
2016 Shinohara M, Murray ME, Frank RD, Shinohara M, DeTure M, Yamazaki Y, Tachibana M, Atagi Y, Davis MD, Liu CC, Zhao N, Painter MM, Petersen RC, Fryer JD, Crook JE, ... ... Bu G, et al. Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer's disease. Acta Neuropathologica. PMID 27179972 DOI: 10.1007/S00401-016-1580-Y  0.637
2016 Fu Y, Zhao J, Atagi Y, Nielsen HM, Liu CC, Zheng H, Shinohara M, Kanekiyo T, Bu G. Apolipoprotein E lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan. Molecular Neurodegeneration. 11: 37. PMID 27151330 DOI: 10.1186/S13024-016-0099-Y  0.653
2016 Zheng H, Liu CC, Atagi Y, Chen XF, Jia L, Yang L, He W, Zhang X, Kang SS, Rosenberry TL, Fryer JD, Zhang YW, Xu H, Bu G. Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation. Neurobiology of Aging. 42: 132-41. PMID 27143430 DOI: 10.1016/J.Neurobiolaging.2016.03.004  0.598
2016 Zhang X, Hu J, Zhong L, Wang N, Yang L, Liu CC, Li H, Wang X, Zhou Y, Zhang Y, Xu H, Bu G, Zhuang J. Quercetin stabilizes apolipoprotein E and reduces brain Aβ levels in amyloid model mice. Neuropharmacology. PMID 27114256 DOI: 10.1016/J.Neuropharm.2016.04.032  0.638
2016 Yuede CM, Lee H, Restivo JL, Davis TA, Hettinger JC, Wallace CE, Young KL, Hayne MR, Bu G, Li CZ, Cirrito JR. Rapid in vivo measurement of β-amyloid reveals biphasic clearance kinetics in an Alzheimer's mouse model. The Journal of Experimental Medicine. PMID 27069115 DOI: 10.1084/Jem.20151428  0.466
2016 Sakae N, Liu CC, Shinohara M, Frisch-Daiello J, Ma L, Yamazaki Y, Tachibana M, Younkin L, Kurti A, Carrasquillo MM, Zou F, Sevlever D, Bisceglio G, Gan M, Fol R, ... ... Bu G, et al. ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 3848-59. PMID 27030769 DOI: 10.1523/Jneurosci.3757-15.2016  0.65
2016 Liu CC, Zhao N, Yamaguchi Y, Cirrito JR, Kanekiyo T, Holtzman DM, Bu G. Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-β clearance and aggregation in Alzheimer's disease. Science Translational Medicine. 8: 332ra44. PMID 27030596 DOI: 10.1126/Scitranslmed.Aad3650  0.61
2016 Li Y, Sun H, Chen Z, Xu H, Bu G, Zheng H. Implications of GABAergic Neurotransmission in Alzheimer's Disease. Frontiers in Aging Neuroscience. 8: 31. PMID 26941642 DOI: 10.3389/Fnagi.2016.00031  0.465
2016 Tai LM, Thomas R, Marottoli FM, Koster KP, Kanekiyo T, Morris AW, Bu G. The role of APOE in cerebrovascular dysfunction. Acta Neuropathologica. PMID 26884068 DOI: 10.1007/s00401-016-1547-z  0.333
2016 Yamazaki Y, Baker DJ, Tachibana M, Liu CC, van Deursen JM, Brott TG, Bu G, Kanekiyo T. Vascular Cell Senescence Contributes to Blood-Brain Barrier Breakdown. Stroke; a Journal of Cerebral Circulation. PMID 26883501 DOI: 10.1161/Strokeaha.115.010835  0.541
2016 Reynolds MR, Singh I, Azad TD, Holmes BB, Verghese PB, Dietrich HH, Diamond M, Bu G, Han BH, Zipfel GJ. Heparan sulfate proteoglycans mediate Aβ-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells. Molecular Neurodegeneration. 11: 9. PMID 26801396 DOI: 10.1186/S13024-016-0073-8  0.4
2016 Zheng H, Liu CC, Atagi Y, Chen XF, Jia L, Yang L, He W, Zhang X, Kang SS, Rosenberry TL, Fryer JD, Zhang YW, Xu H, Bu G. Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation Neurobiology of Aging. 42: 132-141. DOI: 10.1016/j.neurobiolaging.2016.03.004  0.598
2016 Shinohara M, Dickson DW, Bu G. P1-334: Regional Distribution of Amyloid-Beta, Soluble App and Synaptic Markers in Human Brains Alzheimer's & Dementia. 12: P556-P556. DOI: 10.1016/J.Jalz.2016.06.1085  0.341
2016 Kanekiyo T, Bu G. Apolipoprotein E and Amyloid-β-Independent Mechanisms in Alzheimer's Disease Genes, Environment and Alzheimer's Disease. 171-196. DOI: 10.1016/B978-0-12-802851-3.00006-1  0.4
2015 Tachibana M, Shinohara M, Yamazaki Y, Liu CC, Rogers J, Bu G, Kanekiyo T. Rescuing Effects of RXR Agonist Bexarotene on Aging-related Synapse Loss Depend on Neuronal LRP1. Experimental Neurology. PMID 26688581 DOI: 10.1016/j.expneurol.2015.12.003  0.538
2015 Chen XF, Wei Z, Wang T, Zhang ZL, Wang Y, Heckman MG, Diehl NN, Zhang YW, Xu H, Bu G. Demographic and Lifestyle Characteristics, but Not Apolipoprotein E Genotype, Are Associated with Intelligence among Young Chinese College Students. Plos One. 10: e0143157. PMID 26574747 DOI: 10.1371/Journal.Pone.0143157  0.308
2015 Malik M, Parikh I, Vasquez JB, Smith C, Tai L, Bu G, LaDu MJ, Fardo DW, Rebeck GW, Estus S. Genetics ignite focus on microglial inflammation in Alzheimer's disease. Molecular Neurodegeneration. 10: 52. PMID 26438529 DOI: 10.1186/S13024-015-0048-1  0.423
2015 Atagi Y, Liu CC, Painter MM, Chen XF, Verbeeck C, Zheng H, Li X, Rademakers R, Kang SS, Xu H, Younkin S, Das P, Fryer JD, Bu G. Apolipoprotein E is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2). The Journal of Biological Chemistry. PMID 26374899 DOI: 10.1074/Jbc.M115.679043  0.608
2015 Wren MC, Zhao J, Liu CC, Murray ME, Atagi Y, Davis MD, Fu Y, Okano HJ, Ogaki K, Strongosky AJ, Tacik P, Rademakers R, Ross OA, Dickson DW, Wszolek ZK, ... ... Bu G, et al. Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells. Molecular Neurodegeneration. 10: 46. PMID 26373282 DOI: 10.1186/S13024-015-0042-7  0.566
2015 Painter MM, Atagi Y, Liu CC, Rademakers R, Xu H, Fryer JD, Bu G. TREM2 in CNS homeostasis and neurodegenerative disease. Molecular Neurodegeneration. 10: 43. PMID 26337043 DOI: 10.1186/S13024-015-0040-9  0.586
2015 Zhao Y, Tseng IC, Heyser CJ, Rockenstein E, Mante M, Adame A, Zheng Q, Huang T, Wang X, Arslan PE, Chakrabarty P, Wu C, Bu G, Mobley WC, Zhang YW, et al. Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis. Neuron. 87: 963-75. PMID 26335643 DOI: 10.1016/J.Neuron.2015.08.020  0.385
2015 Cook C, Kang SS, Carlomagno Y, Lin WL, Yue M, Kurti A, Shinohara M, Jansen-West K, Perkerson E, Castanedes-Casey M, Rousseau L, Phillips V, Bu G, Dickson DW, Petrucelli L, et al. Tau deposition drives neuropathological, inflammatory, and behavioral abnormalities independently of neuronal loss in a novel mouse model. Human Molecular Genetics. PMID 26276810 DOI: 10.1093/Hmg/Ddv336  0.39
2015 Feng T, Niu M, Ji C, Gao Y, Wen J, Bu G, Xu H, Zhang YW. SNX15 Regulates Cell Surface Recycling of APP and Aβ Generation. Molecular Neurobiology. PMID 26115702 DOI: 10.1007/S12035-015-9306-Z  0.375
2015 Harriott AM, Heckman MG, Rayaprolu S, Soto-Ortolaza AI, Diehl NN, Kanekiyo T, Liu CC, Bu G, Malik R, Cole JW, Meschia JF, Ross OA. Low density lipoprotein receptor related protein 1 and 6 gene variants and ischaemic stroke risk. European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies. 22: 1235-41. PMID 26031789 DOI: 10.1111/Ene.12735  0.522
2015 Zhao Z, Sagare AP, Ma Q, Halliday MR, Kong P, Kisler K, Winkler EA, Ramanathan A, Kanekiyo T, Bu G, Owens NC, Rege SV, Si G, Ahuja A, Zhu D, et al. Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance. Nature Neuroscience. 18: 978-87. PMID 26005850 DOI: 10.1038/Nn.4025  0.474
2015 Casey CS, Atagi Y, Yamazaki Y, Shinohara M, Tachibana M, Fu Y, Bu G, Kanekiyo T. Apolipoprotein E Inhibits Cerebrovascular Pericyte Mobility through a RhoA Protein-mediated Pathway. The Journal of Biological Chemistry. 290: 14208-17. PMID 25903128 DOI: 10.1074/jbc.M114.625251  0.382
2015 Hu J, Liu CC, Chen XF, Zhang YW, Xu H, Bu G. Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice. Molecular Neurodegeneration. 10: 6. PMID 25871773 DOI: 10.1186/S13024-015-0001-3  0.621
2015 Liu CC, Hu J, Tsai CW, Yue M, Melrose HL, Kanekiyo T, Bu G. Neuronal LRP1 regulates glucose metabolism and insulin signaling in the brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 5851-9. PMID 25855193 DOI: 10.1523/Jneurosci.5180-14.2015  0.594
2015 DiBattista AM, Dumanis SB, Song JM, Bu G, Weeber E, William Rebeck G, Hoe HS. Very low density lipoprotein receptor regulates dendritic spine formation in a RasGRF1/CaMKII dependent manner. Biochimica Et Biophysica Acta. 1853: 904-17. PMID 25644714 DOI: 10.1016/J.Bbamcr.2015.01.015  0.334
2015 Hu J, Lin T, Gao Y, Xu J, Jiang C, Wang G, Bu G, Xu H, Chen H, Zhang YW. The resveratrol trimer miyabenol C inhibits β-secretase activity and β-amyloid generation. Plos One. 10: e0115973. PMID 25629409 DOI: 10.1371/Journal.Pone.0115973  0.417
2015 Hou P, Liu G, Zhao Y, Shi Z, Zheng Q, Bu G, Xu H, Zhang YW. The role of copper and the copper-related protein CUTA in mediating APP processing and Aβ generation. Neurobiology of Aging. 36: 1310-5. PMID 25557959 DOI: 10.1016/J.Neurobiolaging.2014.12.005  0.418
2014 Gan M, Jiang P, McLean P, Kanekiyo T, Bu G. Low-density lipoprotein receptor-related protein 1 (LRP1) regulates the stability and function of GluA1 α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor in neurons. Plos One. 9: e113237. PMID 25500815 DOI: 10.1371/Journal.Pone.0113237  0.367
2014 Wang X, Huang T, Zhao Y, Zheng Q, Thompson RC, Bu G, Zhang YW, Hong W, Xu H. Sorting nexin 27 regulates Aβ production through modulating γ-secretase activity. Cell Reports. 9: 1023-33. PMID 25437557 DOI: 10.1016/J.Celrep.2014.09.037  0.472
2014 Chen Y, Peng Y, Che P, Gannon M, Liu Y, Li L, Bu G, van Groen T, Jiao K, Wang Q. α(2A) adrenergic receptor promotes amyloidogenesis through disrupting APP-SorLA interaction. Proceedings of the National Academy of Sciences of the United States of America. 111: 17296-301. PMID 25404298 DOI: 10.1073/Pnas.1409513111  0.412
2014 Liu CC, Tsai CW, Deak F, Rogers J, Penuliar M, Sung YM, Maher JN, Fu Y, Li X, Xu H, Estus S, Hoe HS, Fryer JD, Kanekiyo T, Bu G. Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer's disease. Neuron. 84: 63-77. PMID 25242217 DOI: 10.1016/J.Neuron.2014.08.048  0.646
2014 Wang X, Huang T, Bu G, Xu H. Dysregulation of protein trafficking in neurodegeneration. Molecular Neurodegeneration. 9: 31. PMID 25152012 DOI: 10.1186/1750-1326-9-31  0.365
2014 Liu CC, Kanekiyo T, Roth B, Bu G. Tyrosine-based signal mediates LRP6 receptor endocytosis and desensitization of Wnt/β-catenin pathway signaling. The Journal of Biological Chemistry. 289: 27562-70. PMID 25143377 DOI: 10.1074/Jbc.M113.533927  0.543
2014 Kanekiyo T, Bu G. The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer's disease. Frontiers in Aging Neuroscience. 6: 93. PMID 24904407 DOI: 10.3389/Fnagi.2014.00093  0.53
2014 Sotelo P, Farfán P, Benitez ML, Bu G, Marzolo MP. Sorting nexin 17 regulates ApoER2 recycling and reelin signaling. Plos One. 9: e93672. PMID 24705369 DOI: 10.1371/Journal.Pone.0093672  0.398
2014 Martínez-Morillo E, Hansson O, Atagi Y, Bu G, Minthon L, Diamandis EP, Nielsen HM. Total apolipoprotein E levels and specific isoform composition in cerebrospinal fluid and plasma from Alzheimer's disease patients and controls. Acta Neuropathologica. 127: 633-43. PMID 24633805 DOI: 10.1007/S00401-014-1266-2  0.437
2014 Shinohara M, Fujioka S, Murray ME, Wojtas A, Baker M, Rovelet-Lecrux A, Rademakers R, Das P, Parisi JE, Graff-Radford NR, Petersen RC, Dickson DW, Bu G. Regional distribution of synaptic markers and APP correlate with distinct clinicopathological features in sporadic and familial Alzheimer's disease. Brain : a Journal of Neurology. 137: 1533-49. PMID 24625695 DOI: 10.1093/Brain/Awu046  0.444
2014 Medway CW, Abdul-Hay S, Mims T, Ma L, Bisceglio G, Zou F, Pankratz S, Sando SB, Aasly JO, Barcikowska M, Siuda J, Wszolek ZK, Ross OA, Carrasquillo M, Dickson DW, ... ... Bu G, et al. ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer's disease. Molecular Neurodegeneration. 9: 11. PMID 24607147 DOI: 10.1186/1750-1326-9-11  0.326
2014 Zhao J, Fu Y, Liu CC, Shinohara M, Nielsen HM, Dong Q, Kanekiyo T, Bu G. Retinoic acid isomers facilitate apolipoprotein E production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway. The Journal of Biological Chemistry. 289: 11282-92. PMID 24599963 DOI: 10.1074/Jbc.M113.526095  0.598
2014 Jiang S, Li Y, Zhang C, Zhao Y, Bu G, Xu H, Zhang YW. M1 muscarinic acetylcholine receptor in Alzheimer's disease. Neuroscience Bulletin. 30: 295-307. PMID 24590577 DOI: 10.1007/S12264-013-1406-Z  0.4
2014 Kanekiyo T, Xu H, Bu G. ApoE and Aβ in Alzheimer's disease: accidental encounters or partners? Neuron. 81: 740-54. PMID 24559670 DOI: 10.1016/J.Neuron.2014.01.045  0.499
2014 Jiang S, Li Y, Zhang X, Bu G, Xu H, Zhang YW. Trafficking regulation of proteins in Alzheimer's disease. Molecular Neurodegeneration. 9: 6. PMID 24410826 DOI: 10.1186/1750-1326-9-6  0.459
2014 Martínez-Morillo E, Nielsen HM, Batruch I, Drabovich AP, Begcevic I, Lopez MF, Minthon L, Bu G, Mattsson N, Portelius E, Hansson O, Diamandis EP. Assessment of peptide chemical modifications on the development of an accurate and precise multiplex selected reaction monitoring assay for apolipoprotein e isoforms. Journal of Proteome Research. 13: 1077-87. PMID 24392642 DOI: 10.1021/Pr401060X  0.345
2014 Tai LM, Mehra S, Shete V, Estus S, Rebeck GW, Bu G, LaDu MJ. Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk. Molecular Neurodegeneration. 9: 2. PMID 24386905 DOI: 10.1186/1750-1326-9-2  0.462
2013 Kanekiyo T, Cirrito JR, Liu CC, Shinohara M, Li J, Schuler DR, Shinohara M, Holtzman DM, Bu G. Neuronal clearance of amyloid-β by endocytic receptor LRP1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 19276-83. PMID 24305823 DOI: 10.1523/Jneurosci.3487-13.2013  0.649
2013 Chen XF, Zhang YW, Xu H, Bu G. Transcriptional regulation and its misregulation in Alzheimer's disease. Molecular Brain. 6: 44. PMID 24144318 DOI: 10.1186/1756-6606-6-44  0.446
2013 Wolf AB, Valla J, Bu G, Kim J, LaDu MJ, Reiman EM, Caselli RJ. Apolipoprotein E as a β-amyloid-independent factor in Alzheimer's disease. Alzheimer's Research & Therapy. 5: 38. PMID 23998393 DOI: 10.1186/Alzrt204  0.6
2013 Li X, Liu Y, Zheng Q, Yao G, Cheng P, Bu G, Xu H, Zhang YW. Ferritin light chain interacts with PEN-2 and affects γ-secretase activity. Neuroscience Letters. 548: 90-4. PMID 23685131 DOI: 10.1016/J.Neulet.2013.05.018  0.384
2013 Verghese PB, Castellano JM, Garai K, Wang Y, Jiang H, Shah A, Bu G, Frieden C, Holtzman DM. ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions. Proceedings of the National Academy of Sciences of the United States of America. 110: E1807-16. PMID 23620513 DOI: 10.1073/Pnas.1220484110  0.492
2013 Farfán P, Lee J, Larios J, Sotelo P, Bu G, Marzolo MP. A sorting nexin 17-binding domain within the LRP1 cytoplasmic tail mediates receptor recycling through the basolateral sorting endosome. Traffic (Copenhagen, Denmark). 14: 823-38. PMID 23593972 DOI: 10.1111/Tra.12076  0.352
2013 Wang X, Zhao Y, Zhang X, Badie H, Zhou Y, Mu Y, Loo LS, Cai L, Thompson RC, Yang B, Chen Y, Johnson PF, Wu C, Bu G, Mobley WC, et al. Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nature Medicine. 19: 473-80. PMID 23524343 DOI: 10.1038/Nm.3117  0.356
2013 Shinohara M, Petersen RC, Dickson DW, Bu G. Brain regional correlation of amyloid-β with synapses and apolipoprotein E in non-demented individuals: potential mechanisms underlying regional vulnerability to amyloid-β accumulation. Acta Neuropathologica. 125: 535-47. PMID 23371365 DOI: 10.1007/S00401-013-1086-9  0.437
2013 Liu CC, Liu CC, Kanekiyo T, Xu H, Bu G. Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. Nature Reviews. Neurology. 9: 106-18. PMID 23296339 DOI: 10.1038/Nrneurol.2012.263  0.642
2013 Tai LM, Bilousova T, Jungbauer L, Roeske SK, Youmans KL, Yu C, Poon WW, Cornwell LB, Miller CA, Vinters HV, Van Eldik LJ, Fardo DW, Estus S, Bu G, Gylys KH, et al. Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples. The Journal of Biological Chemistry. 288: 5914-26. PMID 23293020 DOI: 10.1074/Jbc.M112.442103  0.454
2013 Shinohara M, Bu G. What can we learn from regional vulnerability to amyloid-β accumulation in nondemented individuals? Neurodegenerative Disease Management. 3: 187-189. DOI: 10.2217/Nmt.13.20  0.376
2013 N’Songo A, Kanekiyo T, Bu G. LRP1 plays a major role in the amyloid-β clearance in microglia Molecular Neurodegeneration. 8. DOI: 10.1186/1750-1326-8-S1-P33  0.512
2013 Bu G, Liu C, Kanekiyo T. Vascular hypothesis of Alzheimer’s disease: role of apoE and apoE receptors Molecular Neurodegeneration. 8. DOI: 10.1186/1750-1326-8-S1-O20  0.647
2013 Liu CC, Kanekiyo T, Xu H, Bu G. Erratum: Apolipoprotein e and Alzheimer disease: Risk, mechanisms and therapy (Nature Reviews Neurology (2013) 9 (106-118)) Nature Reviews Neurology. 9. DOI: 10.1038/Nrneurol2013.32  0.332
2013 Bu G. S1-01-01: APOE and APOE receptors in brain lipid metabolism, synaptic functions and clearance of beta-amyloid Alzheimer's & Dementia. 9: P121-P121. DOI: 10.1016/J.Jalz.2013.04.032  0.427
2012 Kanekiyo T, Liu CC, Shinohara M, Li J, Bu G. LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 16458-65. PMID 23152628 DOI: 10.1523/Jneurosci.3987-12.2012  0.633
2012 Li J, Kanekiyo T, Shinohara M, Zhang Y, LaDu MJ, Xu H, Bu G. Differential regulation of amyloid-β endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms. The Journal of Biological Chemistry. 287: 44593-601. PMID 23132858 DOI: 10.1074/Jbc.M112.420224  0.466
2012 Zhang H, Zhang YW, Chen Y, Huang X, Zhou F, Wang W, Xian B, Zhang X, Masliah E, Chen Q, Han JD, Bu G, Reed JC, Liao FF, Chen YG, et al. Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 15565-76. PMID 23115192 DOI: 10.1523/Jneurosci.3668-12.2012  0.342
2012 Youmans KL, Tai LM, Nwabuisi-Heath E, Jungbauer L, Kanekiyo T, Gan M, Kim J, Eimer WA, Estus S, Rebeck GW, Weeber EJ, Bu G, Yu C, Ladu MJ. APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease. The Journal of Biological Chemistry. 287: 41774-86. PMID 23060451 DOI: 10.1074/Jbc.M112.407957  0.648
2012 Chen Y, Huang X, Zhang YW, Rockenstein E, Bu G, Golde TE, Masliah E, Xu H. Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 11390-5. PMID 22895721 DOI: 10.1523/Jneurosci.0757-12.2012  0.453
2012 Youmans KL, Tai LM, Kanekiyo T, Stine WB, Michon SC, Nwabuisi-Heath E, Manelli AM, Fu Y, Riordan S, Eimer WA, Binder L, Bu G, Yu C, Hartley DM, LaDu MJ. Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody. Molecular Neurodegeneration. 7: 8. PMID 22423893 DOI: 10.1186/1750-1326-7-8  0.392
2012 Holtzman DM, Herz J, Bu G. Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease. Cold Spring Harbor Perspectives in Medicine. 2: a006312. PMID 22393530 DOI: 10.1101/Cshperspect.A006312  0.519
2012 Liu C, Hoe H, Bu G. Wnt signaling receptor LRP6 interacts with amyloid precursor protein and regulates its trafficking and processing Molecular Neurodegeneration. 7: O5. DOI: 10.1186/1750-1326-7-S1-O5  0.663
2012 Bu G. ApoE and apoE receptors in brain lipid metabolism and AD Molecular Neurodegeneration. 7: L10. DOI: 10.1186/1750-1326-7-S1-L10  0.458
2012 Shinohara M, Dickson D, Bu G. P4-078: Brain regional distribution of apolipoprotein E and beta-amyloid peptides in cognitively normal persons Alzheimer's & Dementia. 8: P660-P661. DOI: 10.1016/J.Jalz.2012.05.1780  0.325
2011 Chen J, Liu CC, Li Q, Nowak C, Bu G, Wang J. Two structural and functional domains of MESD required for proper folding and trafficking of LRP5/6. Structure (London, England : 1993). 19: 313-23. PMID 21397183 DOI: 10.1016/J.Str.2011.01.010  0.515
2011 Kanekiyo T, Zhang J, Liu Q, Liu CC, Zhang L, Bu G. Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-beta uptake. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 1644-51. PMID 21289173 DOI: 10.1523/Jneurosci.5491-10.2011  0.643
2011 Liu Q, Zhang J, Zerbinatti C, Zhan Y, Kolber BJ, Herz J, Muglia LJ, Bu G. Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system. Plos Biology. 9: e1000575. PMID 21264353 DOI: 10.1371/Journal.Pbio.1000575  0.316
2011 Youmans KL, Leung S, Zhang J, Maus E, Baysac K, Bu G, Vassar R, Yu C, LaDu MJ. Amyloid-β42 alters apolipoprotein E solubility in brains of mice with five familial AD mutations. Journal of Neuroscience Methods. 196: 51-9. PMID 21219931 DOI: 10.1016/J.Jneumeth.2010.12.025  0.437
2011 Sakamoto K, Bu G, Chen S, Takei Y, Hibi K, Kodera Y, McCormick LM, Nakao A, Noda M, Muramatsu T, Kadomatsu K. Premature ligand-receptor interaction during biosynthesis limits the production of growth factor midkine and its receptor LDL receptor-related protein 1. The Journal of Biological Chemistry. 286: 8405-13. PMID 21212259 DOI: 10.1074/Jbc.M110.176479  0.361
2010 Liu Q, Trotter J, Zhang J, Peters MM, Cheng H, Bao J, Han X, Weeber EJ, Bu G. Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 17068-78. PMID 21159977 DOI: 10.1523/Jneurosci.4067-10.2010  0.467
2010 Owen JB, Sultana R, Aluise CD, Erickson MA, Price TO, Bu G, Banks WA, Butterfield DA. Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: implications for Aβ accumulation in AD brain. Free Radical Biology & Medicine. 49: 1798-803. PMID 20869432 DOI: 10.1016/J.Freeradbiomed.2010.09.013  0.36
2010 Fuentealba RA, Liu Q, Zhang J, Kanekiyo T, Hu X, Lee JM, LaDu MJ, Bu G. Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal Abeta42 uptake and lysosomal trafficking. Plos One. 5: e11884. PMID 20686698 DOI: 10.1371/Journal.Pone.0011884  0.429
2010 Li Y, Lu W, King TD, Liu CC, Bijur GN, Bu G. Dkk1 stabilizes Wnt co-receptor LRP6: implication for Wnt ligand-induced LRP6 down-regulation. Plos One. 5: e11014. PMID 20543981 DOI: 10.1371/Journal.Pone.0011014  0.568
2010 Chen J, Li Q, Liu CC, Zhou P, Zhou B, Bu G, Wang J. NMR structure note: solution structure of the core domain of MESD that is essential for proper folding of LRP5/6. Journal of Biomolecular Nmr. 47: 283-8. PMID 20506034 DOI: 10.1007/s10858-010-9426-8  0.391
2010 Lu W, Liu CC, Thottassery JV, Bu G, Li Y. Mesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cells. Biochemistry. 49: 4635-43. PMID 20446724 DOI: 10.1021/Bi1001486  0.548
2010 Liu CC, Prior J, Piwnica-Worms D, Bu G. LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy. Proceedings of the National Academy of Sciences of the United States of America. 107: 5136-41. PMID 20194742 DOI: 10.1073/Pnas.0911220107  0.486
2009 Hu X, Crick SL, Bu G, Frieden C, Pappu RV, Lee JM. Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide Proceedings of the National Academy of Sciences of the United States of America. 106: 20324-20329. PMID 19910533 DOI: 10.1073/Pnas.0911281106  0.404
2009 Grear KE, Ling IF, Simpson JF, Furman JL, Simmons CR, Peterson SL, Schmitt FA, Markesbery WR, Liu Q, Crook JE, Younkin SG, Bu G, Estus S. Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain. Molecular Neurodegeneration. 4: 46. PMID 19889229 DOI: 10.1186/1750-1326-4-46  0.429
2009 Kanekiyo T, Bu G. Receptor-associated protein interacts with amyloid-beta peptide and promotes its cellular uptake. The Journal of Biological Chemistry. 284: 33352-9. PMID 19826010 DOI: 10.1074/Jbc.M109.015032  0.479
2009 Fuentealba RA, Liu Q, Kanekiyo T, Zhang J, Bu G. Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway. The Journal of Biological Chemistry. 284: 34045-53. PMID 19815552 DOI: 10.1074/Jbc.M109.021030  0.394
2009 Song H, Bu G. MicroRNA-205 inhibits tumor cell migration through down-regulating the expression of the LDL receptor-related protein 1. Biochemical and Biophysical Research Communications. 388: 400-5. PMID 19665999 DOI: 10.1016/J.Bbrc.2009.08.020  0.338
2009 Hoe HS, Lee KJ, Carney RS, Lee J, Markova A, Lee JY, Howell BW, Hyman BT, Pak DT, Bu G, Rebeck GW. Interaction of reelin with amyloid precursor protein promotes neurite outgrowth. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 7459-73. PMID 19515914 DOI: 10.1523/Jneurosci.4872-08.2009  0.436
2009 Liu Q, Zhang J, Tran H, Verbeek MM, Reiss K, Estus S, Bu G. LRP1 shedding in human brain: roles of ADAM10 and ADAM17. Molecular Neurodegeneration. 4: 17. PMID 19371428 DOI: 10.1186/1750-1326-4-17  0.432
2009 Bu G. Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy. Nature Reviews. Neuroscience. 10: 333-44. PMID 19339974 DOI: 10.1038/Nrn2620  0.505
2009 Liu CC, Pearson C, Bu G. Cooperative folding and ligand-binding properties of LRP6 beta-propeller domains. The Journal of Biological Chemistry. 284: 15299-307. PMID 19339249 DOI: 10.1074/jbc.M807285200  0.48
2009 Marzolo MP, Bu G. Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease. Seminars in Cell & Developmental Biology. 20: 191-200. PMID 19041409 DOI: 10.1016/J.Semcdb.2008.10.005  0.485
2009 Kanekiyo T, Bu G. LRP1 and cerebral amyloid angiopathy Future Neurology. 4: 55-65. DOI: 10.2217/14796708.4.1.55  0.481
2008 Knisely JM, Lee J, Bu G. Measurement of receptor endocytosis and recycling. Methods in Molecular Biology (Clifton, N.J.). 457: 319-32. PMID 19066038 DOI: 10.1007/978-1-59745-261-8_24  0.779
2008 Doray B, Knisely JM, Wartman L, Bu G, Kornfeld S. Identification of acidic dileucine signals in LRP9 that interact with both GGAs and AP-1/AP-2. Traffic (Copenhagen, Denmark). 9: 1551-62. PMID 18627575 DOI: 10.1111/J.1600-0854.2008.00786.X  0.758
2008 Bu G, Lu W, Liu CC, Selander K, Yoneda T, Hall C, Keller ET, Li Y. Breast cancer-derived Dickkopf1 inhibits osteoblast differentiation and osteoprotegerin expression: implication for breast cancer osteolytic bone metastases. International Journal of Cancer. Journal International Du Cancer. 123: 1034-42. PMID 18546262 DOI: 10.1002/Ijc.23625  0.419
2008 Cirrito JR, Kang JE, Lee J, Stewart FR, Verges DK, Silverio LM, Bu G, Mennerick S, Holtzman DM. Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo. Neuron. 58: 42-51. PMID 18400162 DOI: 10.1016/J.Neuron.2008.02.003  0.418
2008 Parkyn CJ, Vermeulen EG, Mootoosamy RC, Sunyach C, Jacobsen C, Oxvig C, Moestrup S, Liu Q, Bu G, Jen A, Morris RJ. LRP1 controls biosynthetic and endocytic trafficking of neuronal prion protein. Journal of Cell Science. 121: 773-83. PMID 18285446 DOI: 10.1242/Jcs.021816  0.339
2008 Lee J, Retamal C, Cuitiño L, Caruano-Yzermans A, Shin JE, van Kerkhof P, Marzolo MP, Bu G. Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes. The Journal of Biological Chemistry. 283: 11501-8. PMID 18276590 DOI: 10.1074/jbc.M800642200  0.317
2008 Bu G. S3-02-01: Role of LRP in APOE and Abeta metabloism Alzheimer's & Dementia. 4: T151-T151. DOI: 10.1016/J.Jalz.2008.05.378  0.385
2008 Fuentealba RA, Bu G. P4-246: Low density lipoprotein receptor-related protein 1 (LRP1) mediates anti-apoptotic signaling in primary neurons Alzheimer's & Dementia. 4: T743-T744. DOI: 10.1016/J.Jalz.2008.05.2314  0.326
2007 Wilhelmus MM, Otte-Höller I, van Triel JJ, Veerhuis R, Maat-Schieman ML, Bu G, de Waal RM, Verbeek MM. Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells. The American Journal of Pathology. 171: 1989-99. PMID 18055545 DOI: 10.2353/Ajpath.2007.070050  0.382
2007 Liu Q, Zerbinatti CV, Zhang J, Hoe HS, Wang B, Cole SL, Herz J, Muglia L, Bu G. Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron. 56: 66-78. PMID 17920016 DOI: 10.1016/J.Neuron.2007.08.008  0.52
2007 Knisely JM, Li Y, Griffith JM, Geuze HJ, Schwartz AL, Bu G. Slow endocytosis of the LDL receptor-related protein 1B: implications for a novel cytoplasmic tail conformation. Experimental Cell Research. 313: 3298-307. PMID 17658514 DOI: 10.1016/J.Yexcr.2007.05.026  0.773
2007 Fuentealba RA, Barría MI, Lee J, Cam J, Araya C, Escudero CA, Inestrosa NC, Bronfman FC, Bu G, Marzolo MP. ApoER2 expression increases Abeta production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of gamma-secretase activity. Molecular Neurodegeneration. 2: 14. PMID 17620134 DOI: 10.1186/1750-1326-2-14  0.807
2007 Yuseff MI, Farfan P, Bu G, Marzolo MP. A cytoplasmic PPPSP motif determines megalin's phosphorylation and regulates receptor's recycling and surface expression. Traffic (Copenhagen, Denmark). 8: 1215-30. PMID 17555532 DOI: 10.1111/J.1600-0854.2007.00601.X  0.333
2007 Doray B, Lee I, Knisely J, Bu G, Kornfeld S. The gamma/sigma1 and alpha/sigma2 hemicomplexes of clathrin adaptors AP-1 and AP-2 harbor the dileucine recognition site. Molecular Biology of the Cell. 18: 1887-96. PMID 17360967 DOI: 10.1091/Mbc.E07-01-0012  0.754
2006 Bu G, Cam J, Zerbinatti C. LRP in amyloid-beta production and metabolism. Annals of the New York Academy of Sciences. 1086: 35-53. PMID 17185504 DOI: 10.1196/Annals.1377.005  0.818
2006 Rebeck GW, LaDu MJ, Estus S, Bu G, Weeber EJ. The generation and function of soluble apoE receptors in the CNS. Molecular Neurodegeneration. 1: 15. PMID 17062143 DOI: 10.1186/1750-1326-1-15  0.359
2006 Zerbinatti CV, Wahrle SE, Kim H, Cam JA, Bales K, Paul SM, Holtzman DM, Bu G. Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Abeta42 accumulation in amyloid model mice. The Journal of Biological Chemistry. 281: 36180-6. PMID 17012232 DOI: 10.1074/Jbc.M604436200  0.814
2006 Cam JA, Bu G. Modulation of beta-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family. Molecular Neurodegeneration. 1: 8. PMID 16930455 DOI: 10.1186/1750-1326-1-8  0.815
2006 Knisely JM, Bu G. Genetics and molecular biology: motive studies in mice--two NPXY motifs in the intracellular domain of lipoprotein receptor-related protein 1 exhibit differential importance during fetal development. Current Opinion in Lipidology. 17: 480-2. PMID 16832172 DOI: 10.1097/01.Mol.0000236374.80872.23  0.768
2006 LaDu MJ, Stine WB, Narita M, Getz GS, Reardon CA, Bu G. Self-assembly of HEK cell-secreted ApoE particles resembles ApoE enrichment of lipoproteins as a ligand for the LDL receptor-related protein. Biochemistry. 45: 381-90. PMID 16401069 DOI: 10.1021/Bi051765S  0.442
2006 Chen X, Zhong L, Wang T, Wang Z, Bu G. O4-02-01: SOLUBLE TREM2 MODULATES MICROGLIAL FUNCTION AND PROTECTS AGAINST AMYLOID PATHOLOGY Alzheimer's & Dementia. 14: P1402-P1402. DOI: 10.1016/J.Jalz.2018.06.2915  0.327
2006 Bu G. PL-04-01: PATHOBIOLOGY OF APOE IN ALZHEIMER'S DISEASE Alzheimer's & Dementia. 14: P1399-P1399. DOI: 10.1016/J.Jalz.2018.06.2905  0.397
2006 Yamazaki Y, Liu C, Oue H, Kurti A, Yamazaki A, Fryer JD, Kanekiyo T, Bu G. P4-065: APOE4 CONDITIONALLY EXPRESSED IN CEREBROVASCULATURE IMPAIRS ENDOTHELIAL FUNCTIONS AND INDUCES COGNITIVE DEFICITS Alzheimer's & Dementia. 14: P1457-P1458. DOI: 10.1016/J.Jalz.2018.06.2468  0.502
2006 Yamada K, Yabuki C, Tachikawa M, Ohtsuki S, Strickland DK, Bu G, Terasaki T, Hashimoto T, Iwatsubo T. AbstractPoster presentation: Wednesday posterP4-069: Modeling amyloid β-peptide transport across the blood-brain barrier in TR-BBB cells Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.1807  0.325
2006 Verbeek MM, Wilhelmus MM, Otte-Holler I, Bu G, Maat-Schieman ML, Veerhuis R, Kuesters B, de Waal RM. P4-035: Amyloid β protein receptors in Alzheimer's disease Alzheimer's & Dementia. 2: S523-S523. DOI: 10.1016/J.Jalz.2006.05.1773  0.418
2006 Marzolo M, Fuentealba R, Inestrosa NC, Bu G. P3-429: ApoER2 modulates APP trafficking and regulates secreted abeta levels Alzheimer's & Dementia. 2: S502-S502. DOI: 10.1016/J.Jalz.2006.05.1700  0.334
2005 Wu LJ, Toyoda H, Zhao MG, Lee YS, Tang J, Ko SW, Jia YH, Shum FW, Zerbinatti CV, Bu G, Wei F, Xu TL, Muglia LJ, Chen ZF, Auberson YP, et al. Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 11107-16. PMID 16319310 DOI: 10.1523/Jneurosci.1678-05.2005  0.302
2005 Li Y, Chen J, Lu W, McCormick LM, Wang J, Bu G. Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding. Journal of Cell Science. 118: 5305-14. PMID 16263759 DOI: 10.1242/Jcs.02651  0.346
2005 Cuitino L, Matute R, Retamal C, Bu G, Inestrosa NC, Marzolo MP. ApoER2 is endocytosed by a clathrin-mediated process involving the adaptor protein Dab2 independent of its Rafts' association. Traffic (Copenhagen, Denmark). 6: 820-38. PMID 16101684 DOI: 10.1111/J.1600-0854.2005.00320.X  0.402
2005 Pastrana DV, Hanson AJ, Knisely J, Bu G, Fitzgerald DJ. LRP 1 B functions as a receptor for Pseudomonas exotoxin. Biochimica Et Biophysica Acta. 1741: 234-9. PMID 16095885 DOI: 10.1016/J.Bbadis.2005.06.007  0.764
2005 van Kerkhof P, Lee J, McCormick L, Tetrault E, Lu W, Schoenfish M, Oorschot V, Strous GJ, Klumperman J, Bu G. Sorting nexin 17 facilitates LRP recycling in the early endosome. The Embo Journal. 24: 2851-61. PMID 16052210 DOI: 10.1038/Sj.Emboj.7600756  0.354
2005 Li Y, Lu W, Bu G. Striking differences of LDL receptor-related protein 1B expression in mouse and human. Biochemical and Biophysical Research Communications. 333: 868-73. PMID 15963947 DOI: 10.1016/J.Bbrc.2005.05.170  0.331
2005 Zerbinatti CV, Bu G. LRP and Alzheimer's disease Reviews in the Neurosciences. 16: 123-135. PMID 15959937 DOI: 10.1515/Revneuro.2005.16.2.123  0.55
2005 Fryer JD, Demattos RB, McCormick LM, O'Dell MA, Spinner ML, Bales KR, Paul SM, Sullivan PM, Parsadanian M, Bu G, Holtzman DM. The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice. The Journal of Biological Chemistry. 280: 25754-9. PMID 15888448 DOI: 10.1074/Jbc.M502143200  0.504
2005 McCormick LM, Urade R, Arakaki Y, Schwartz AL, Bu G. Independent and cooperative roles of N-glycans and molecular chaperones in the folding and disulfide bond formation of the low-density lipoprotein (LDL) receptor-related protein. Biochemistry. 44: 5794-803. PMID 15823038 DOI: 10.1021/Bi047652A  0.337
2005 Green PS, Bales K, Paul S, Bu G. Estrogen therapy fails to alter amyloid deposition in the PDAPP model of Alzheimer's disease Endocrinology. 146: 2774-2781. PMID 15731362 DOI: 10.1210/En.2004-1433  0.448
2005 Cam JA, Zerbinatti CV, Li Y, Bu G. Rapid endocytosis of the low density lipoprotein receptor-related protein modulates cell surface distribution and processing of the beta-amyloid precursor protein. The Journal of Biological Chemistry. 280: 15464-70. PMID 15705569 DOI: 10.1074/Jbc.M500613200  0.819
2004 Li Y, Lu W, He X, Schwartz AL, Bu G. LRP6 expression promotes cancer cell proliferation and tumorigenesis by altering beta-catenin subcellular distribution. Oncogene. 23: 9129-35. PMID 15516984 DOI: 10.1038/Sj.Onc.1208123  0.356
2004 Pan W, Kastin AJ, Zankel TC, van Kerkhof P, Terasaki T, Bu G. Efficient transfer of receptor-associated protein (RAP) across the blood-brain barrier. Journal of Cell Science. 117: 5071-8. PMID 15383619 DOI: 10.1242/Jcs.01381  0.372
2004 Prince WS, McCormick LM, Wendt DJ, Fitzpatrick PA, Schwartz KL, Aguilera AI, Koppaka V, Christianson TM, Vellard MC, Pavloff N, Lemontt JF, Qin M, Starr CM, Bu G, Zankel TC. Lipoprotein receptor binding, cellular uptake, and lysosomal delivery of fusions between the receptor-associated protein (RAP) and alpha-L-iduronidase or acid alpha-glucosidase. The Journal of Biological Chemistry. 279: 35037-46. PMID 15170390 DOI: 10.1074/Jbc.M402630200  0.348
2004 Cam JA, Zerbinatti CV, Knisely JM, Hecimovic S, Li Y, Bu G. The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production. The Journal of Biological Chemistry. 279: 29639-46. PMID 15126508 DOI: 10.1074/Jbc.M313893200  0.815
2004 Zerbinatti CV, Wozniak DF, Cirrito J, Cam JA, Osaka H, Bales KR, Zhuo M, Paul SM, Holtzman DM, Bu G. Increased soluble amyloid-beta peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein. Proceedings of the National Academy of Sciences of the United States of America. 101: 1075-80. PMID 14732699 DOI: 10.1073/Pnas.0305803101  0.813
2004 Zerbinatti CV, Bales KR, Paul SM, Bu G. P2-116 Neuronal overexpression of LRP selectively increases a detergent-soluble pool of hippocampal abeta in PDAPP mice Neurobiology of Aging. 25: S257. DOI: 10.1016/S0197-4580(04)80863-7  0.32
2004 Fryer JD, DeMattos RB, O'Dell MA, Spinner ML, Bales KR, Paul SM, Parsadanian M, Bu G, Holtzman DM. O1-03-04 The LDL receptor regulates levels of CNS and Alzheimer's disease-like pathology Neurobiology of Aging. 25: S14-S15. DOI: 10.1016/S0197-4580(04)80047-2  0.401
2003 Li Y, Lu W, Bu G. Essential role of the low density lipoprotein receptor-related protein in vascular smooth muscle cell migration. Febs Letters. 555: 346-50. PMID 14644440 DOI: 10.1016/S0014-5793(03)01272-9  0.317
2003 Knisely JM, Bu G. Genetics and molecular biology. Current Opinion in Lipidology. 14: 401-3. PMID 12865740 DOI: 10.1097/00041433-200308000-00012  0.735
2003 Marzolo MP, Yuseff MI, Retamal C, Donoso M, Ezquer F, Farfán P, Li Y, Bu G. Differential distribution of low-density lipoprotein-receptor-related protein (LRP) and megalin in polarized epithelial cells is determined by their cytoplasmic domains. Traffic (Copenhagen, Denmark). 4: 273-88. PMID 12694565 DOI: 10.1034/J.1600-0854.2003.00081.X  0.332
2002 Narita M, Holtzman DM, Fagan AM, LaDu MJ, Yu L, Han X, Gross RW, Bu G, Schwartz AL. Cellular catabolism of lipid poor apolipoprotein E via cell surface LDL receptor-related protein. Journal of Biochemistry. 132: 743-9. PMID 12417024 DOI: 10.1093/oxfordjournals.jbchem.a003282  0.334
2002 Melman L, Geuze HJ, Li Y, McCormick LM, Van Kerkhof P, Strous GJ, Schwartz AL, Bu G. Proteasome regulates the delivery of LDL receptor-related protein into the degradation pathway. Molecular Biology of the Cell. 13: 3325-35. PMID 12221136 DOI: 10.1091/Mbc.E02-03-0152  0.378
2002 Shibata Y, Muramatsu T, Hirai M, Inui T, Kimura T, Saito H, McCormick LM, Bu G, Kadomatsu K. Nuclear targeting by the growth factor midkine. Molecular and Cellular Biology. 22: 6788-96. PMID 12215536 DOI: 10.1128/Mcb.22.19.6788-6796.2002  0.338
2002 Li Y, Knisely JM, Lu W, McCormick LM, Wang J, Henkin J, Schwartz AL, Bu G. Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration. The Journal of Biological Chemistry. 277: 42366-71. PMID 12194987 DOI: 10.1074/Jbc.M207705200  0.783
2002 Gent J, van Kerkhof P, Roza M, Bu G, Strous GJ. Ligand-independent growth hormone receptor dimerization occurs in the endoplasmic reticulum and is required for ubiquitin system-dependent endocytosis. Proceedings of the National Academy of Sciences of the United States of America. 99: 9858-63. PMID 12105275 DOI: 10.1073/Pnas.152294299  0.33
2002 Li Y, Lu W, Schwartz AL, Bu G. Receptor-associated protein facilitates proper folding and maturation of the low-density lipoprotein receptor and its class 2 mutants. Biochemistry. 41: 4921-8. PMID 11939787 DOI: 10.1021/Bi011894I  0.366
2002 Su HP, Nakada-Tsukui K, Tosello-Trampont AC, Li Y, Bu G, Henson PM, Ravichandran KS. Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP). The Journal of Biological Chemistry. 277: 11772-9. PMID 11729193 DOI: 10.1074/Jbc.M109336200  0.341
2001 Li Y, Cam J, Bu G. Low-density lipoprotein receptor family: Endocytosis and signal transduction Molecular Neurobiology. 23: 53-67. PMID 11642543 DOI: 10.1385/Mn:23:1:53  0.785
2001 LaDu MJ, Shah JA, Reardon CA, Getz GS, Bu G, Hu J, Guo L, Van Eldik LJ. Apolipoprotein E and apolipoprotein E receptors modulate A beta-induced glial neuroinflammatory responses. Neurochemistry International. 39: 427-34. PMID 11578778 DOI: 10.1016/S0197-0186(01)00050-X  0.409
2001 van Kerkhof P, Alves dos Santos CM, Sachse M, Klumperman J, Bu G, Strous GJ. Proteasome inhibitors block a late step in lysosomal transport of selected membrane but not soluble proteins. Molecular Biology of the Cell. 12: 2556-66. PMID 11514635 DOI: 10.1091/Mbc.12.8.2556  0.316
2001 Liu CX, Li Y, Obermoeller-McCormick LM, Schwartz AL, Bu G. The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein. The Journal of Biological Chemistry. 276: 28889-96. PMID 11384978 DOI: 10.1074/jbc.M102727200  0.522
2001 Melman L, Cao ZF, Rennke S, Marzolo MP, Wardell MR, Bu G. High affinity binding of receptor-associated protein to heparin and low density lipoprotein receptor-related protein requires similar basic amino acid sequence motifs. The Journal of Biological Chemistry. 276: 29338-46. PMID 11382778 DOI: 10.1074/Jbc.M103717200  0.308
2001 Li Y, Lu W, Marzolo MP, Bu G. Differential Functions of Members of the Low Density Lipoprotein Receptor Family Suggested by their Distinct Endocytosis Rates Journal of Biological Chemistry. 276: 18000-18006. PMID 11279214 DOI: 10.1074/Jbc.M101589200  0.364
2001 Li Y, van Kerkhof P, Marzolo MP, Strous GJ, Bu G. Identification of a major cyclic AMP-dependent protein kinase A phosphorylation site within the cytoplasmic tail of the low-density lipoprotein receptor-related protein: implication for receptor-mediated endocytosis. Molecular and Cellular Biology. 21: 1185-95. PMID 11158305 DOI: 10.1128/Mcb.21.4.1185-1195.2001  0.347
2000 Bu G, Marzolo MP. Role of RAP in the biogenesis of lipoprotein receptors Trends in Cardiovascular Medicine. 10: 148-155. PMID 11239794 DOI: 10.1016/S1050-1738(00)00045-1  0.358
2000 Liu Y, Jones M, Hingtgen CM, Bu G, Laribee N, Tanzi RE, Moir RD, Nath A, He JJ. Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands. Nature Medicine. 6: 1380-7. PMID 11100124 DOI: 10.1038/82199  0.353
2000 LaDu MJ, Shah JA, Reardon CA, Getz GS, Bu G, Hu J, Guo L, van Eldik LJ. Apolipoprotein E receptors mediate the effects of beta-amyloid on astrocyte cultures. The Journal of Biological Chemistry. 275: 33974-80. PMID 10940295 DOI: 10.1074/Jbc.M000602200  0.455
2000 Ladu MJ, Reardon C, Van Eldik L, Fagan AM, Bu G, Holtzman D, Getz GS. Lipoproteins in the central nervous system. Annals of the New York Academy of Sciences. 903: 167-75. PMID 10818504 DOI: 10.1111/J.1749-6632.2000.Tb06365.X  0.351
2000 Marzolo MP, Von Bernhardi R, Bu G, Inestrosa NC. Expression of α2-macroglobulin receptor/low density lipoprotein receptor-related protein (LRP) in rat microglial cells Journal of Neuroscience Research. 60: 401-411. PMID 10797543 DOI: 10.1002/(Sici)1097-4547(20000501)60:3<401::Aid-Jnr15>3.0.Co;2-L  0.406
2000 Li Y, Marzolo MP, van Kerkhof P, Strous GJ, Bu G. The YXXL motif, but not the two NPXY motifs, serves as the dominant endocytosis signal for low density lipoprotein receptor-related protein. The Journal of Biological Chemistry. 275: 17187-94. PMID 10747918 DOI: 10.1074/Jbc.M000490200  0.365
2000 Zhuo M, Holtzman DM, Li Y, Osaka H, DeMaro J, Jacquin M, Bu G. Role of tissue plasminogen activator receptor LRP in hippocampal long-term potentiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 542-9. PMID 10632583 DOI: 10.1523/Jneurosci.20-02-00542.2000  0.382
2000 LaDu MJ, Shah JA, Reardon CA, Getz GS, Bu G, Hu J, Van Eldik LJ. Apolipoprotein E and its receptors mediate the effects of β-amyloid-induced inflammation in primary astrocyte cultures Neurobiology of Aging. 21: 148-149. DOI: 10.1016/S0197-4580(00)82468-9  0.353
1999 Hamik A, Setiadi H, Bu G, McEver RP, Morrissey JH. Down-regulation of monocyte tissue factor mediated by tissue factor pathway inhibitor and the low density lipoprotein receptor-related protein. The Journal of Biological Chemistry. 274: 4962-9. PMID 9988740 DOI: 10.1074/Jbc.274.8.4962  0.378
1998 Obermoeller LM, Ghen Z, Schwartz AL, Bu G. Ca2+ and receptor-associated protein are independently required for proper folding and disulfide bond formation of the low density lipoprotein receptor-related protein Journal of Biological Chemistry. 273: 22374-22381. PMID 9712858 DOI: 10.1074/Jbc.273.35.22374  0.312
1998 Fagan AM, Murphy BA, Patel SN, Kilbridge JF, Mobley WC, Bu G, Holtzman DM. Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury. Experimental Neurology. 151: 314-25. PMID 9628766 DOI: 10.1006/Exnr.1998.6818  0.384
1998 Bu G, Sun Y, Schwartz AL, Holtzman DM. Nerve growth factor induces rapid increases in functional cell surface low density lipoprotein receptor-related protein Journal of Biological Chemistry. 273: 13359-13365. PMID 9582384 DOI: 10.1074/Jbc.273.21.13359  0.361
1998 Sun Y, Wu S, Bu G, Onifade MK, Patel SN, LaDu MJ, Fagan AM, Holtzman DM. Glial Fibrillary Acidic Protein–Apolipoprotein E (apoE) Transgenic Mice: Astrocyte-Specific Expression and Differing Biological Effects of Astrocyte-Secreted apoE3 and apoE4 Lipoproteins The Journal of Neuroscience. 18: 3261-3272. DOI: 10.1523/Jneurosci.18-09-03261.1998  0.432
1997 Narita M, Holtzman DM, Schwartz AL, Bu G. α2-macroglobulin complexes with and mediates the endocytosis of β- amyloid peptide via cell surface low-density lipoprotein receptor-related protein Journal of Neurochemistry. 69: 1904-1911. PMID 9349534 DOI: 10.1046/J.1471-4159.1997.69051904.X  0.474
1997 Farhangrazi ZS, Ying H, Bu G, Dugan LL, Fagan AM, Choi DW, Holtzman DM. High density lipoprotein decreases beta-amyloid toxicity in cortical cell culture. Neuroreport. 8: 1127-30. PMID 9175098 DOI: 10.1097/00001756-199703240-00013  0.409
1997 Fagan AM, Bu G, Sun Y, Daugherty A, Holtzman DM. Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein. The Journal of Biological Chemistry. 271: 30121-5. PMID 8939961 DOI: 10.1074/Jbc.271.47.30121  0.432
1996 Bu G, Rennke S. Receptor-associated protein is a folding chaperone for low density lipoprotein receptor-related protein Journal of Biological Chemistry. 271: 22218-22224. PMID 8703036 DOI: 10.1074/Jbc.271.36.22218  0.382
1995 Warshawsky I, Bu G, Mast A, Saffitz JE, Broze GJ, Schwartz AL. The carboxy terminus of tissue factor pathway inhibitor is required for interacting with hepatoma cells in vitro and in vivo Journal of Clinical Investigation. 95: 1773-1781. PMID 7706485 DOI: 10.1172/Jci117855  0.333
1995 Holtzman DM, Pitas RE, Kilbridge J, Nathan B, Mahley RW, Bu G, Schwartz AL. Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line. Proceedings of the National Academy of Sciences of the United States of America. 92: 9480-4. PMID 7568158 DOI: 10.1073/Pnas.92.21.9480  0.439
1995 Narita M, Bu G, Olins GM, Higuchi DA, Herz J, Broze GJ, Schwartz AL. Two receptor systems are involved in the plasma clearance of tissue factor pathway inhibitor in vivo. The Journal of Biological Chemistry. 270: 24800-4. PMID 7559599 DOI: 10.1074/Jbc.270.42.24800  0.354
1995 Vettenranta K, Bu G, Schwartz AL. Binding and endocytosis of 39 kDa protein by MDBK cells Journal of Cellular Physiology. 164: 441-447. PMID 7542665 DOI: 10.1002/Jcp.1041640225  0.338
1994 Warshawsky I, Bu G, Schwartz AL. LRP and the receptor-mediated endocytosis of plasminogen activators Annals of the New York Academy of Sciences. 737: 70-87. PMID 7944155 DOI: 10.1111/J.1749-6632.1994.Tb44302.X  0.303
1993 Iadonato SP, Bu G, Maksymovitch EA, Schwartz AL. Interaction of a 39 kDa protein with the low-density-lipoprotein-receptor-related protein (LRP) on rat hepatoma cells Biochemical Journal. 296: 867-875. PMID 8280086 DOI: 10.1042/Bj2960867  0.356
1993 Warshawsky I, Bu G, Schwartz AL. Identification of domains on the 39-kDa protein that inhibit the binding of ligands to the low density lipoprotein receptor-related protein Journal of Biological Chemistry. 268: 22046-22054. PMID 7691821 DOI: 10.1111/J.1749-6632.1994.Tb44357.X  0.308
Low-probability matches (unlikely to be authored by this person)
2013 Lin C, Lu W, Zhang W, Londoño-Joshi AI, Buchsbaum DJ, Bu G, Li Y. The C-terminal region Mesd peptide mimics full-length Mesd and acts as an inhibitor of Wnt/β-catenin signaling in cancer cells. Plos One. 8: e58102. PMID 23469146 DOI: 10.1371/Journal.Pone.0058102  0.3
1995 Warshawsky I, Bu G, Schwartz AL. Sites within the 39-kDa protein important for regulating ligand binding to the low-density lipoprotein receptor-related protein Biochemistry. 34: 3404-3415. PMID 7533537 DOI: 10.1021/Bi00010A032  0.298
1995 Narita M, Bu G, Herz J, Schwartz AL. Two receptor systems are involved in the plasma clearance of tissue-type plasminogen activator (t-PA) in vivo Journal of Clinical Investigation. 96: 1164-1168. PMID 7635954 DOI: 10.1172/Jci118105  0.296
2006 Bi GQ, Bolshakov V, Bu G, Cahill CM, Chen ZF, Collingridge GL, Cooper RL, Coorssen JR, El-Husseini A, Galhardo V, Gan WB, Gu J, Inoue K, Isaac J, Iwata K, et al. Recent advances in basic neurosciences and brain disease: from synapses to behavior. Molecular Pain. 2: 38. PMID 17196111 DOI: 10.1186/1744-8069-2-38  0.296
2013 Chen F, Radisky ES, Das P, Batra J, Hata T, Hori T, Baine AM, Gardner L, Yue MY, Bu G, del Zoppo G, Patel TC, Nguyen JH. TIMP-1 attenuates blood-brain barrier permeability in mice with acute liver failure. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 33: 1041-9. PMID 23532086 DOI: 10.1038/Jcbfm.2013.45  0.296
1993 Warshawsky I, Bu G, Schwartz AL. 39-kD protein inhibits tissue-type plasminogen activator clearance in vivo Journal of Clinical Investigation. 92: 937-944. PMID 8349826 DOI: 10.1172/Jci116669  0.295
2006 Li Y, Lu W, He X, Bu G. Modulation of LRP6-mediated Wnt signaling by molecular chaperone Mesd. Febs Letters. 580: 5423-8. PMID 16989816 DOI: 10.1016/J.Febslet.2006.09.011  0.294
1994 Bu G, Warshawsky I, Schwartz AL. Cellular receptors for the plasminogen activators Blood. 83: 3427-3436. PMID 8204869 DOI: 10.1182/Blood.V83.12.3427.3427  0.293
2009 Song H, Li Y, Lee J, Schwartz AL, Bu G. Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9. Cancer Research. 69: 879-86. PMID 19176371 DOI: 10.1158/0008-5472.Can-08-3379  0.292
1992 Bu G, Williams S, Strickland DK, Schwartz AL. Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor is an hepatic receptor for tissue-type plasminogen activator. Proceedings of the National Academy of Sciences of the United States of America. 89: 7427-31. PMID 1502154 DOI: 10.1073/Pnas.89.16.7427  0.29
2023 Le Guen Y, Raulin AC, Logue MW, Sherva R, Belloy ME, Eger SJ, Chen A, Kennedy G, Kuchenbecker L, O'Leary JP, Zhang R, Merritt VC, Panizzon MS, Hauger RL, Gaziano JM, ... Bu G, et al. Association of African Ancestry-Specific APOE Missense Variant R145C With Risk of Alzheimer Disease. Jama. 329: 551-560. PMID 36809323 DOI: 10.1001/jama.2023.0268  0.288
2001 van Kerkhof P, dos Santos CMA, Sachse M, Klumperman J, Bu G, Strous GJ. Lysosomal degradation of the growth hormone receptor is regulated by the ubiquitin-proteasome pathway Biochemical Society Transactions. 29: A64-A64. DOI: 10.1042/Bst029A064A  0.287
2017 Ando M, Fiesel FC, Hudec R, Caulfield TR, Ogaki K, Górka-Skoczylas P, Koziorowski D, Friedman A, Chen L, Dawson VL, Dawson TM, Bu G, Ross OA, Wszolek ZK, Springer W. The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity. Molecular Neurodegeneration. 12: 32. PMID 28438176 DOI: 10.1186/S13024-017-0174-Z  0.287
2015 Zhou J, Li H, Li X, Zhang G, Niu Y, Yuan Z, Herrup K, Zhang YW, Bu G, Xu H, Zhang J. The roles of Cdk5-mediated subcellular localization of FOXO1 in neuronal death. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 2624-35. PMID 25673854 DOI: 10.1523/Jneurosci.3051-14.2015  0.286
2022 Giannisis A, Patra K, Edlund AK, Nieto LA, Benedicto-Gras J, Moussaud S, de la Rosa A, Twohig D, Bengtsson T, Fu Y, Bu G, Bial G, Foquet L, Hammarstedt C, Strom S, et al. Brain integrity is altered by hepatic APOE ε4 in humanized-liver mice. Molecular Psychiatry. PMID 35418601 DOI: 10.1038/s41380-022-01548-0  0.283
2016 Nielsen HM, Chen K, Lee W, Chen Y, Reiman EM, Caselli RJ, Bu G. P4-149: Peripheral Apoe Levels are Associated with Regional Gray Matter Volume, Cerebral Glucose Metabolism and Cognitive Performance in Cognitively Normal APOE E3/4 Carriers Alzheimer's & Dementia. 12: P1071-P1071. DOI: 10.1016/J.Jalz.2016.06.2240  0.281
2015 Zhang L, Zhang S, Maezawa I, Trushin S, Minhas P, Pinto M, Jin LW, Prasain K, Nguyen TD, Yamazaki Y, Kanekiyo T, Bu G, Gateno B, Chang KO, Nath KA, et al. Modulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's Disease. Ebiomedicine. 2: 294-305. PMID 26086035 DOI: 10.1016/J.Ebiom.2015.03.009  0.281
2008 Liu Q, Zhang J, Tran H, Verbeek M, Reiss K, Saftig P, Estus S, Bu G. P4-226: LRP1 shedding in human brain: Roles of ADAM 10 and 17 Alzheimer's & Dementia. 4: T737-T738. DOI: 10.1016/J.Jalz.2008.05.2294  0.278
2019 Marzano M, Bejoy J, Cheerathodi MR, Sun L, York SB, Zhao J, Kanekiyo T, Bu G, Meckes DG, Li Y. Differential Effects of Extracellular Vesicles of Lineage-Specific Human Pluripotent Stem Cells on the Cellular Behaviors of Isogenic Cortical Spheroids. Cells. 8. PMID 31466320 DOI: 10.3390/Cells8090993  0.278
1994 Bu G, Morton PA, Schwartz AL. Receptor-Mediated Endocytosis of Plasminogen Activators Advances in Molecular and Cell Biology. 8: 87-131. DOI: 10.1016/S1569-2558(08)60369-0  0.277
2006 Carrasquillo MM, Reddy JS, Allen M, Reyes DA, McDonnell SK, Graff-Radford J, Kosel ML, Gregory JD, Nguyen T, Lincoln SJ, Malphrus KG, Crook JE, Jack CR, Lowe VJ, Knopman DS, ... ... Bu G, et al. P3-132: GENOME-WIDE ASSOCIATION STUDY OF CEREBRAL MICROBLEEDS AND INFARCTION IDENTIFIES CANDIDATE GENES FOR VASCULAR RISK IN DEMENTIA Alzheimer's & Dementia. 14: P1118-P1118. DOI: 10.1016/J.Jalz.2018.06.1489  0.276
1998 Rall SC, Ye P, Bu G, Wardell MR. The domain structure of human receptor-associated protein. Protease sensitivity and guanidine HCl denaturation. The Journal of Biological Chemistry. 273: 24152-7. PMID 9727037 DOI: 10.1074/Jbc.273.37.24152  0.272
1994 Bu G, Maksymovitch EA, Nerbonne JM, Schwartz AL. Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neurons Journal of Biological Chemistry. 269: 18521-18528. PMID 7518435  0.27
2008 Hoe H, Lee KJ, Lee JY, Carney RSE, Makarova A, Chakrabarti L, Lee J, Howell BW, Hyman BT, Pak DTS, Bu G, Rebeck GW. P3-385: Reelin-APP-integrin interactions promote neurite outgrowth in hippocampal neurons Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.1955  0.269
1997 Narita M, Bu G, Holtzman DM, Schwartz AL. The low-density lipoprotein receptor-related protein, a multifunctional apolipoprotein E receptor, modulates hippocampal neurite development Journal of Neurochemistry. 68: 587-595. PMID 9003044 DOI: 10.1046/J.1471-4159.1997.68020587.X  0.267
2017 Ogaki K, Martens Y, Heckman M, Koga S, Fujioka S, Kanekiyo T, Wszolek Z, Singer W, Low P, Dickson D, Hattori N, Bu G, Ross O. Multiple system atrophy and apolipoprotein E: genetic analysis and functional study Journal of the Neurological Sciences. 381: 459. DOI: 10.1016/J.Jns.2017.08.3504  0.262
2021 Aikawa T, Ren Y, Holm ML, Asmann YW, Alam A, Fitzgerald ML, Bu G, Kanekiyo T. ABCA7 Regulates Brain Fatty Acid Metabolism During LPS-Induced Acute Inflammation. Frontiers in Neuroscience. 15: 647974. PMID 33897360 DOI: 10.3389/fnins.2021.647974  0.262
2016 Shinohara M, Kanekiyo T, Yang L, Linthicum D, Shinohara M, Fu Y, Price L, Frisch-Daiello JL, Han X, Fryer JD, Bu G. APOE2 eases cognitive decline during aging: clinical and preclinical evaluations. Annals of Neurology. PMID 26933942 DOI: 10.1002/ana.24628  0.262
2001 Bu G. The roles of receptor-associated protein (RAP) as a molecular chaperone for members of the LDL receptor family International Review of Cytology. 209: 79-116. PMID 11580203 DOI: 10.1016/S0074-7696(01)09011-8  0.262
2017 Shinohara M, Koga S, Konno T, Nix J, Shinohara M, Aoki N, Das P, Parisi JE, Petersen RC, Rosenberry TL, Dickson DW, Bu G. Distinct spatiotemporal accumulation of N-truncated and full-length amyloid-β42 in Alzheimer's disease. Brain : a Journal of Neurology. PMID 29161341 DOI: 10.1093/Brain/Awx284  0.259
2023 Hou X, Chen TH, Koga S, Bredenberg JM, Faroqi AH, Delenclos M, Bu G, Wszolek ZK, Carr JA, Ross OA, McLean PJ, Murray ME, Dickson DW, Fiesel FC, Springer W. Alpha-synuclein-associated changes in PINK1-PRKN-mediated mitophagy are disease context dependent. Brain Pathology (Zurich, Switzerland). e13175. PMID 37259617 DOI: 10.1111/bpa.13175  0.257
1994 Bu G, Maksymovitch EA, Geuze H, Schwartz AL. Subcellular localization and endocytic function of low density lipoprotein receptor-related protein in human glioblastoma cells Journal of Biological Chemistry. 269: 29874-29882. PMID 7961982  0.248
2020 Watzlawik JO, Hou X, Truban D, Ramnarine C, Barodia SK, Gendron TF, Heckman MG, DeTure M, Siuda J, Wszolek ZK, Scherzer CR, Ross OA, Bu G, Dickson DW, Goldberg MS, et al. Sensitive ELISA-based detection method for the mitophagy marker p-S65-Ub in human cells, autopsy brain, and blood samples. Autophagy. 1-16. PMID 33112198 DOI: 10.1080/15548627.2020.1834712  0.246
2023 Kloske CM, Barnum CJ, Batista AF, Bradshaw EM, Brickman AM, Bu G, Dennison J, Gearon MD, Goate AM, Haass C, Heneka MT, Hu WT, Huggins LKL, Jones NS, Koldamova R, et al. APOE and immunity: Research highlights. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 36975090 DOI: 10.1002/alz.13020  0.245
2008 Yamada K, Hashimoto T, Yabuki C, Nagae Y, Tachikawa M, Strickland DK, Liu Q, Bu G, Basak JM, Holtzman DM, Ohtsuki S, Terasaki T, Iwatsubo T. The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells. The Journal of Biological Chemistry. 283: 34554-62. PMID 18940800 DOI: 10.1074/Jbc.M801487200  0.244
1995 Bu G, Geuze HJ, Strous GJ, Schwartz AL. 39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein Embo Journal. 14: 2269-2280. PMID 7774585  0.243
2022 Feng T, Niu M, Ji C, Gao Y, Wen J, Bu G, Xu H, Zhang YW. Correction to: SNX15 Regulates Cell Surface Recycling of APP and Aβ Generation. Molecular Neurobiology. PMID 36322338 DOI: 10.1007/s12035-022-03097-7  0.242
2014 Zheng H, Tang R, Yao Y, Ji Z, Cao Y, Liu Z, Peng F, Wang W, Can D, Xing H, Bu G, Xu H, Zhang YW, Zheng W. MiR-219 Protects Against Seizure in the Kainic Acid Model of Epilepsy. Molecular Neurobiology. PMID 25394384 DOI: 10.1007/S12035-014-8981-5  0.242
1997 Bu G, Rennke S, Geuze HJ. ERD2 proteins mediate ER retention of the HNEL signal of LRP's receptor-associated protein (RAP) Journal of Cell Science. 110: 65-73. PMID 9010785  0.239
2023 Hou X, Heckman MG, Fiesel FC, Koga S, Soto-Beasley AI, Watzlawik JO, Zhao J, Valentino RR, Johnson PW, White LJ, Quicksall ZS, Reddy JS, Bras J, Guerreiro R, Zhao N, ... Bu G, et al. Genome-wide association study identifies and variants as mitophagy modifiers in Lewy body disease. Medrxiv : the Preprint Server For Health Sciences. PMID 37905059 DOI: 10.1101/2023.10.16.23297100  0.239
2015 Nielsen HM, Atagi Y, Hallström T, Fu Y, Zipfel PF, Bu G. O3-06-04: Apolipoprotein e affects neuronal alpha-synuclein uptake in an isoform-dependent manner Alzheimer's & Dementia. 11: P231-P231. DOI: 10.1016/J.Jalz.2015.07.270  0.237
2017 Li Y, Chen Z, Gao Y, Pan G, Zheng H, Zhang Y, Xu H, Bu G, Zheng H. Synaptic adhesion molecule Pcdh-γC5 mediates synaptic dysfunction in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28842416 DOI: 10.1523/Jneurosci.1051-17.2017  0.237
2019 Hsieh CH, Li L, Vanhauwaert R, Nguyen KT, Davis MD, Bu G, Wszolek ZK, Wang X. Miro1 Marks Parkinson's Disease Subset and Miro1 Reducer Rescues Neuron Loss in Parkinson's Models. Cell Metabolism. PMID 31564441 DOI: 10.1016/J.Cmet.2019.08.023  0.235
2020 Qu W, Wang Z, Hare JM, Bu G, Mallea JM, Pascual JM, Caplan AI, Kurtzberg J, Zubair AC, Kubrova E, Engelberg-Cook E, Nayfeh T, Shah VP, Hill JC, Wolf ME, et al. Cell-based therapy to reduce mortality from COVID-19: Systematic review and meta-analysis of human studies on acute respiratory distress syndrome. Stem Cells Translational Medicine. PMID 32472653 DOI: 10.1002/Sctm.20-0146  0.234
1999 Moulder KL, Narita M, Chang LK, Bu G, Johnson EM. Analysis of a novel mechanism of neuronal toxicity produced by an apolipoprotein E-derived peptide. Journal of Neurochemistry. 72: 1069-80. PMID 10037478 DOI: 10.1046/J.1471-4159.1999.0721069.X  0.234
1999 Savonen R, Obermoeller LM, Trausch-Azar JS, Schwartz AL, Bu G. The carboxyl-terminal domain of receptor-associated protein facilitates proper folding and trafficking of the very low density lipoprotein receptor by interaction with the three amino-terminal ligand-binding repeats of the receptor. The Journal of Biological Chemistry. 274: 25877-82. PMID 10464330 DOI: 10.1074/jbc.274.36.25877  0.233
2014 Nielsen HM, Fu Y, Bu G. P4-024: APOLIPOPROTEIN E: AN UNEXPLORED MODULATOR OF CELLULAR ALPHA-SYNUCLEIN UPTAKE Alzheimer's & Dementia. 10: P791-P792. DOI: 10.1016/J.Jalz.2014.05.1538  0.232
2022 Raulin AC, Martens YA, Bu G. Lipoproteins in the Central Nervous System: From Biology to Pathobiology. Annual Review of Biochemistry. PMID 35303786 DOI: 10.1146/annurev-biochem-032620-104801  0.232
2018 Ogaki K, Heckman MG, Koga S, Martens YA, Labbé C, Lorenzo-Betancor O, Walton RL, Soto AI, Vargas ER, Fujioka S, Uitti RJ, van Gerpen JA, Cheshire WP, Younkin SG, Wszolek ZK, ... ... Bu G, et al. Association study between multiple system atrophy and TREM2 p.R47H. Neurology. Genetics. 4: e257. PMID 30109269 DOI: 10.1212/Nxg.0000000000000257  0.232
2023 Kawatani K, Holm ML, Starling SC, Martens YA, Zhao J, Lu W, Ren Y, Li Z, Jiang P, Jiang Y, Baker SK, Wang N, Roy B, Parsons TM, Perkerson RB, ... ... Bu G, et al. ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism. Molecular Psychiatry. PMID 38135757 DOI: 10.1038/s41380-023-02372-w  0.229
1998 Bu G, Schwartz AL. RAP, a novel type of ER chaperone. Trends in Cell Biology. 8: 272-6. PMID 9714598 DOI: 10.1016/S0962-8924(98)01283-5  0.228
2023 Fu Y, Bu G, Kanekiyo T, Zhao J. Counteracting Alzheimer's disease via somatic TERT activation. Nature Aging. 1: 1081-1082. PMID 37117526 DOI: 10.1038/s43587-021-00145-0  0.228
2017 Ando M, Fiesel F, Hudec R, Caulfield T, Ogaki K, Górka-Skoczylas P, Koziorowski D, Friedman A, Chen L, Dawson V, Dawson T, Bu G, Ross O, Wszolek Z, Springer W. The PINK1 p.I368N mutation affects protein stability and disrupts kinase activity Journal of the Neurological Sciences. 381: 214. DOI: 10.1016/J.Jns.2017.08.612  0.227
2018 ANDO M, FIESEL FC, HUDEC R, CAULFIELD TR, OGAKI K, GÓRKA-SKOCZYLAS P, KOZIOROWSKI D, FRIEDMAN A, CHEN L, DAWSON VL, DAWSON TM, BU G, ROSS OA, WSZOLEK ZK, SPRINGER W. The PINK1 p.I368N Mutation Affects Protein Stability and Kinase Activity with Its Structural Change Juntendo Medical Journal. 64: 17-30. DOI: 10.14789/Jmj.2018.64.Jmjjmj17-R10  0.223
1998 Bu G. Receptor-associated protein: A specialized chaperone and antagonist for members of the LDL receptor gene family Current Opinion in Lipidology. 9: 149-155. PMID 9559273 DOI: 10.1097/00041433-199804000-00012  0.223
2021 Syrjanen JA, Campbell MR, Algeciras-Schimnich A, Vemuri P, Graff-Radford J, Machulda MM, Bu G, Knopman DS, Jack CR, Petersen RC, Mielke MM. Associations of amyloid and neurodegeneration plasma biomarkers with comorbidities. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 34569696 DOI: 10.1002/alz.12466  0.222
2015 Zhong L, Chen XF, Zhang ZL, Wang Z, Shi XZ, Xu K, Zhang YW, Xu H, Bu G. DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response. The Journal of Biological Chemistry. 290: 15866-77. PMID 25957402 DOI: 10.1074/Jbc.M115.645986  0.215
1997 Obermoeller LM, Warshawsky I, Wardell MR, Bu G. Differential functions of triplicated repeats suggest two independent roles for the receptor-associated protein as a molecular chaperone Journal of Biological Chemistry. 272: 10761-10768. PMID 9099728 DOI: 10.1074/jbc.272.16.10761  0.214
2009 Donoso M, Cancino J, Lee J, van Kerkhof P, Retamal C, Bu G, Gonzalez A, Cáceres A, Marzolo MP. Polarized traffic of LRP1 involves AP1B and SNX17 operating on Y-dependent sorting motifs in different pathways. Molecular Biology of the Cell. 20: 481-97. PMID 19005208 DOI: 10.1091/mbc.E08-08-0805  0.212
2013 Xing H, Zheng H, Wang J, Qiu J, Qiao Z, Peng Z, Shao Y, Xu H, Bu G. Increased menin expression associated with neural apoptosis in the frontal cortex of SIV infected macaques Journal of the Neurological Sciences. 333: e349-e350. DOI: 10.1016/J.Jns.2013.07.1285  0.211
2002 Swertfeger DK, Bu G, Hui DY. Low density lipoprotein receptor-related protein mediates apolipoprotein E inhibition of smooth muscle cell migration Journal of Biological Chemistry. 277: 4141-4146. PMID 11739389 DOI: 10.1074/jbc.M109124200  0.21
2006 Lisi S, Botta R, Pinchera A, Collins AB, Refetoff S, Arvan P, Bu G, Grasso L, Marshansky V, Bechoua S, Hurtado-Lorenzo A, Marcocci C, Brown D, McCluskey RT, Marinò M. Defective thyroglobulin storage in LDL receptor-associated protein-deficient mice. American Journal of Physiology. Cell Physiology. 290: C1160-7. PMID 16306127 DOI: 10.1152/Ajpcell.00382.2005  0.209
2009 Woodley DT, Fan J, Cheng CF, Li Y, Chen M, Bu G, Li W. Participation of the lipoprotein receptor LRP1 in hypoxia-HSP90alpha autocrine signaling to promote keratinocyte migration. Journal of Cell Science. 122: 1495-8. PMID 19383717 DOI: 10.1242/jcs.047894  0.209
2005 Benchenane K, Berezowski V, Ali C, Fernández-Monreal M, López-Atalaya JP, Brillault J, Chuquet J, Nouvelot A, MacKenzie ET, Bu G, Cecchelli R, Touzani O, Vivien D. Tissue-type plasminogen activator crosses the intact blood-brain barrier by low-density lipoprotein receptor-related protein-mediated transcytosis. Circulation. 111: 2241-9. PMID 15851587 DOI: 10.1161/01.CIR.0000163542.48611.A2  0.207
2011 Wilhelmus MM, Bol JG, Van Haastert ES, Rozemuller AJ, Bu G, Drukarch B, Hoozemans JJ. Apolipoprotein E and LRP1 Increase Early in Parkinson's Disease Pathogenesis. The American Journal of Pathology. 179: 2152-6. PMID 21907175 DOI: 10.1016/j.ajpath.2011.07.021  0.204
2016 Zhong L, Xie YZ, Cao TT, Wang Z, Wang T, Li X, Shen RC, Xu H, Bu G, Chen XF. A rapid and cost-effective method for genotyping apolipoprotein E gene polymorphism. Molecular Neurodegeneration. 11: 2. PMID 26754117 DOI: 10.1186/S13024-016-0069-4  0.202
2022 Bu G. APOE targeting strategy in Alzheimer's disease: lessons learned from protective variants. Molecular Neurodegeneration. 17: 51. PMID 35922805 DOI: 10.1186/s13024-022-00556-6  0.202
2007 Chen J, Bu G, Wang J. A complete NMR spectral assignment of the conserved region of the MESD protein, MESD(12-155). Biomolecular Nmr Assignments. 1: 3-5. PMID 19636811 DOI: 10.1007/s12104-007-9003-6  0.202
2023 Zhao Z, Sagare AP, Ma Q, Halliday MR, Kong P, Kisler K, Winkler EA, Ramanathan A, Kanekiyo T, Bu G, Owens NC, Rege SV, Si G, Ahuja A, Zhu D, et al. Author Correction: Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance. Nature Neuroscience. PMID 37985802 DOI: 10.1038/s41593-023-01509-y  0.201
2010 Jen A, Parkyn CJ, Mootoosamy RC, Ford MJ, Warley A, Liu Q, Bu G, Baskakov IV, Moestrup S, McGuinness L, Emptage N, Morris RJ. Neuronal low-density lipoprotein receptor-related protein 1 binds and endocytoses prion fibrils via receptor cluster 4. Journal of Cell Science. 123: 246-55. PMID 20048341 DOI: 10.1242/Jcs.058099  0.198
2024 Chen XF, Bu G. TREMendous microglial effects on neurons. Immunity. 57: 1-3. PMID 38198847 DOI: 10.1016/j.immuni.2023.12.007  0.198
2022 Rossi SL, Subramanian P, Bu G, Di Polo A, Golde TE, Bovenkamp DE. Common features of neurodegenerative disease: exploring the brain-eye connection and beyond (part 2): the 2021 pre-symposium of the 15th international conference on Alzheimer's and Parkinson's diseases. Molecular Neurodegeneration. 17: 69. PMID 36316783 DOI: 10.1186/s13024-022-00571-7  0.197
2022 Rossi SL, Subramanian P, Bu G, Di Polo A, Golde TE, Bovenkamp DE. Common features of neurodegenerative disease: exploring the brain-eye connection and beyond (Part 1): the 2021 pre-symposium of the 15th international conference on Alzheimer's and Parkinson's diseases. Molecular Neurodegeneration. 17: 68. PMID 36310167 DOI: 10.1186/s13024-022-00570-8  0.197
2003 Shirotani-Ikejima H, Kokame K, Hamuro T, Bu G, Kato H, Miyata T. Tissue factor pathway inhibitor induces expression of JUNB and GADD45B mRNAs. Biochemical and Biophysical Research Communications. 299: 847-52. PMID 12470656 DOI: 10.1016/S0006-291X(02)02759-6  0.188
2005 Lee J, Bu G. Genetics and molecular biology: ABCA1 in brain apolipoprotein E metabolism and lipidation. Current Opinion in Lipidology. 16: 115-7. PMID 15650570  0.183
2023 Woodley DT, Fan J, Cheng CF, Li Y, Chen M, Bu G, Li W. Expression of Concern: Participation of the lipoprotein receptor LRP1 in hypoxia-HSP90α autocrine signaling to promote keratinocyte migration. Journal of Cell Science. 136. PMID 37930799 DOI: 10.1242/jcs.261643  0.183
2022 Al-Kharboosh R, Perera JJ, Bechtle A, Bu G, Quinones-Hinojosa A. Emerging point-of-care autologous cellular therapy using adipose-derived stromal vascular fraction for neurodegenerative diseases. Clinical and Translational Medicine. 12: e1093. PMID 36495120 DOI: 10.1002/ctm2.1093  0.181
2002 Green PS, Bu G. Genetics and molecular biology: Phosphorylation of low-density lipoprotein receptor-related protein by platelet-derived growth factor Current Opinion in Lipidology. 13: 569-572. PMID 12352020 DOI: 10.1097/00041433-200210000-00013  0.181
2022 Mielke MM, Dage JL, Frank RD, Algeciras-Schimnich A, Knopman DS, Lowe VJ, Bu G, Vemuri P, Graff-Radford J, Jack CR, Petersen RC. Performance of plasma phosphorylated tau 181 and 217 in the community. Nature Medicine. PMID 35618838 DOI: 10.1038/s41591-022-01822-2  0.18
2022 Wareham LK, Liddelow SA, Temple S, Benowitz LI, Di Polo A, Wellington C, Goldberg JL, He Z, Duan X, Bu G, Davis AA, Shekhar K, Torre A, Chan DC, Canto-Soler MV, et al. Solving neurodegeneration: common mechanisms and strategies for new treatments. Molecular Neurodegeneration. 17: 23. PMID 35313950 DOI: 10.1186/s13024-022-00524-0  0.177
2016 Yuede CM, Lee H, Restivo JL, Davis TA, Hettinger JC, Wallace CE, Young KL, Hayne MR, Bu G, Li C, Cirrito JR. Rapid in vivo measurement of β-amyloid reveals biphasic clearance kinetics in an Alzheimer’s mouse model The Journal of Cell Biology. 213: 2132OIA84. DOI: 10.1083/jcb.2132OIA84  0.177
2021 Mielke MM, Frank RD, Dage JL, Jeromin A, Ashton NJ, Blennow K, Karikari TK, Vanmechelen E, Zetterberg H, Algeciras-Schimnich A, Knopman DS, Lowe V, Bu G, Vemuri P, Graff-Radford J, et al. Comparison of Plasma Phosphorylated Tau Species With Amyloid and Tau Positron Emission Tomography, Neurodegeneration, Vascular Pathology, and Cognitive Outcomes. Jama Neurology. PMID 34309632 DOI: 10.1001/jamaneurol.2021.2293  0.175
1993 Bu G, Maksymovitch EA, Schwartz AL. Receptor-mediated endocytosis of tissue-type plasminogen activator by low density lipoprotein receptor-related protein on human hepatoma HepG2 cells Journal of Biological Chemistry. 268: 13002-13009. PMID 8389767  0.175
2009 Zhang J, Li Y, Liu Q, Lu W, Bu G. Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: implication for breast cancer tumorigenesis. Oncogene. 29: 539-49. PMID 19881541 DOI: 10.1038/Onc.2009.339  0.174
2021 Shinohara M, Suzuki K, Bu G, Sato N. Interaction Between APOE Genotype and Diabetes in Longevity. Journal of Alzheimer's Disease : Jad. PMID 34092638 DOI: 10.3233/JAD-210125  0.174
2016 Wang C, Niu M, Zhou Z, Zheng X, Zhang L, Tian Y, Yu X, Bu G, Xu H, Ma Q, Zhang YW. VPS35 regulates cell surface recycling and signaling of dopamine receptor D1. Neurobiology of Aging. 46: 22-31. PMID 27460146 DOI: 10.1016/J.Neurobiolaging.2016.05.016  0.173
1994 Warshawsky I, Bu G, Schwartz AL. Binding analysis of amino-terminal and carboxyl-terminal regions of the 39-kDa protein to the low density lipoprotein receptor-related protein Journal of Biological Chemistry. 269: 3325-3330. PMID 7508911  0.171
2023 O'Leary J, Raulin AC, Li Z, Martens Y, Inoue Y, Strickland MR, Han X, Holtzman DM, Bu G, Zhao N. Standardized immunoprecipitation protocol for efficient isolation of native apolipoprotein E particles utilizing HJ15.4 monoclonal antibody. Star Protocols. 4: 102271. PMID 37289593 DOI: 10.1016/j.xpro.2023.102271  0.17
2019 Zhang L, Zhang S, Maezawa I, Trushin S, Minhas P, Pinto M, Jin LW, Prasain K, Nguyen TDT, Yamazaki Y, Kanekiyo T, Bu G, Gateno B, Chang KO, Nath KA, et al. Corrigendum to "Modulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's disease" [EBioMedicine 2 (2015) 294-305]. Ebiomedicine. PMID 30956174 DOI: 10.1016/J.Ebiom.2019.03.062  0.168
2016 Zheng Q, Zheng X, Zhang L, Luo H, Qian L, Fu X, Liu Y, Gao Y, Niu M, Meng J, Zhang M, Bu G, Xu H, Zhang YW. The Neuron-Specific Protein TMEM59L Mediates Oxidative Stress-Induced Cell Death. Molecular Neurobiology. PMID 27324899 DOI: 10.1007/S12035-016-9997-9  0.166
2010 Lin L, Bu G, Mars WM, Reeves WB, Tanaka S, Hu K. tPA activates LDL receptor-related protein 1-mediated mitogenic signaling involving the p90RSK and GSK3beta pathway. The American Journal of Pathology. 177: 1687-96. PMID 20724593 DOI: 10.2353/ajpath.2010.100213  0.165
2008 Hu K, Lin L, Tan X, Yang J, Bu G, Mars WM, Liu Y. tPA protects renal interstitial fibroblasts and myofibroblasts from apoptosis. Journal of the American Society of Nephrology : Jasn. 19: 503-14. PMID 18199803 DOI: 10.1681/ASN.2007030300  0.164
2013 Liu CC, Kanekiyo T, Xu H, Bu G. Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy Nature Reviews Neurology. DOI: 10.1038/Nrneurol.2013.32  0.164
2004 Li Y, Lu W, Schwartz AL, Bu G. Degradation of the LDL receptor class 2 mutants is mediated by a proteasome-dependent pathway. Journal of Lipid Research. 45: 1084-91. PMID 14993243 DOI: 10.1194/jlr.M300482-JLR200  0.163
2007 Chen S, Bu G, Takei Y, Sakamoto K, Ikematsu S, Muramatsu T, Kadomatsu K. Midkine and LDL-receptor-related protein 1 contribute to the anchorage-independent cell growth of cancer cells. Journal of Cell Science. 120: 4009-15. PMID 17971413 DOI: 10.1242/jcs.013946  0.162
2018 Ogaki K, Martens YA, Heckman MG, Koga S, Labbé C, Lorenzo-Betancor O, Wernick AI, Walton RL, Soto AI, Vargas ER, Nielsen HM, Fujioka S, Kanekiyo T, Uitti RJ, van Gerpen JA, ... ... Bu G, et al. Multiple system atrophy and apolipoprotein E. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 29442376 DOI: 10.1002/Mds.27297  0.16
2018 Zhuang K, Huang C, Leng L, Zheng H, Gao Y, Chen G, Ji Z, Sun H, Hu Y, Wu D, Shi M, Li H, Zhao Y, Zhang Y, Xue M, ... Bu G, et al. Neuron-Specific Menin Deletion Leads to Synaptic Dysfunction and Cognitive Impairment by Modulating p35 Expression. Cell Reports. 24: 701-712. PMID 30021166 DOI: 10.1016/J.Celrep.2018.06.055  0.16
2011 Nishitsuji K, Hosono T, Nakamura T, Bu G, Michikawa M. Apolipoprotein E regulates the integrity of tight junctions in an isoform-dependent manner in an in vitro blood-brain barrier model. The Journal of Biological Chemistry. 286: 17536-42. PMID 21471207 DOI: 10.1074/jbc.M111.225532  0.159
2005 Li Y, Bu G. LRP5/6 in Wnt signaling and tumorigenesis. Future Oncology (London, England). 1: 673-81. PMID 16556044 DOI: 10.2217/14796694.1.5.673  0.159
2017 Valdez C, Wong YC, Schwake M, Bu G, Wszolek ZK, Krainc D. Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients. Human Molecular Genetics. PMID 29036611 DOI: 10.1093/Hmg/Ddx364  0.158
2004 Li Y, Bu G. LRP5, a multifunctional cell surface receptor Current Opinion in Lipidology. 15: 361-363. PMID 15166794 DOI: 10.1097/00041433-200406000-00018  0.156
2016 Kang R, Li P, Wang T, Li X, Wei Z, Zhang Z, Zhong L, Cao L, Heckman MG, Zhang YW, Xu H, Huang C, Bu G, Chen XF. Apolipoprotein E epsilon 2 allele and low serum cholesterol as risk factors for gastric cancer in a Chinese Han population. Scientific Reports. 6: 19930. PMID 26817942 DOI: 10.1038/Srep19930  0.155
2018 Leng L, Zhuang K, Liu Z, Huang C, Gao Y, Chen G, Lin H, Hu Y, Wu D, Shi M, Xie W, Sun H, Shao Z, Li H, Zhang K, ... ... Bu G, et al. Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation. Neuron. PMID 30220511 DOI: 10.1016/J.Neuron.2018.08.031  0.151
2015 Bu G, Liang X, Li J, Wang Y. Extra-pituitary prolactin (PRL) and prolactin-like protein (PRL-L) in chickens and zebrafish. General and Comparative Endocrinology. 220: 143-53. PMID 25683198 DOI: 10.1016/j.ygcen.2015.02.001  0.143
2019 Liu Q, Zhang J, Zerbinatti C, Zhan Y, Kolber BJ, Herz J, Muglia LJ, Bu G. Correction: Lipoprotein Receptor LRP1 Regulates Leptin Signaling and Energy Homeostasis in the Adult Central Nervous System. Plos Biology. 17: e3000310. PMID 31163031 DOI: 10.1371/Journal.Pbio.3000310  0.143
2012 Pi X, Schmitt CE, Xie L, Portbury AL, Wu Y, Lockyer P, Dyer LA, Moser M, Bu G, Flynn EJ, Jin SW, Patterson C. LRP1-dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis. Circulation Research. 111: 564-74. PMID 22777006 DOI: 10.1161/Circresaha.112.274597  0.141
2004 Fernández-Monreal M, López-Atalaya JP, Benchenane K, Léveillé F, Cacquevel M, Plawinski L, MacKenzie ET, Bu G, Buisson A, Vivien D. Is tissue-type plasminogen activator a neuromodulator? Molecular and Cellular Neurosciences. 25: 594-601. PMID 15080889 DOI: 10.1016/j.mcn.2003.11.002  0.135
2016 Zhang YJ, Gendron TF, Grima JC, Sasaguri H, Jansen-West K, Xu YF, Katzman RB, Gass J, Murray ME, Shinohara M, Lin WL, Garrett A, Stankowski JN, Daughrity L, Tong J, ... ... Bu G, et al. C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins. Nature Neuroscience. PMID 26998601 DOI: 10.1038/Nn.4272  0.131
2017 Yuan H, Jiang W, von Roemeling CA, Qie Y, Liu X, Chen Y, Wang Y, Wharen RE, Yun K, Bu G, Knutson KL, Kim BYS. Multivalent bi-specific nanobioconjugate engager for targeted cancer immunotherapy. Nature Nanotechnology. PMID 28459470 DOI: 10.1038/Nnano.2017.69  0.13
1997 Hardy MM, Feder J, Wolfe RA, Bu G. Low density lipoprotein receptor-related protein modulates the expression of tissue-type plasminogen activator in human colon fibroblasts Journal of Biological Chemistry. 272: 6812-6817. PMID 9045716 DOI: 10.1074/jbc.272.10.6812  0.126
2021 Rademakers R, Nicholson AM, Ren Y, Koga S, Nguyen HP, Brooks M, Qiao W, Quicksall ZS, Matchett B, Perkerson RB, Kurti A, Castanedes-Casey M, Phillips V, Librero AL, Fernandez De Castro CH, ... ... Bu G, et al. Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits. Brain Pathology (Zurich, Switzerland). e12945. PMID 33709463 DOI: 10.1111/bpa.12945  0.125
2009 Zhang Y, Owens L, Bu G. Meeting report: 2009 international conference on molecular neurodegeneration May 18-20, 2009, Xiamen, China. Molecular Neurodegeneration. 4: 43. PMID 19860909 DOI: 10.1186/1750-1326-4-43  0.124
2020 Prudencio M, Garcia-Moreno H, Jansen-West KR, Al-Shaikh RH, Gendron TF, Heckman MG, Spiegel MR, Carlomagno Y, Daughrity LM, Song Y, Dunmore JA, Byron N, Oskarsson B, Nicholson KA, Staff NP, ... ... Bu G, et al. Toward allele-specific targeting therapy and pharmacodynamic marker for spinocerebellar ataxia type 3. Science Translational Medicine. 12. PMID 33087504 DOI: 10.1126/scitranslmed.abb7086  0.123
2016 Zhang C, Shi Z, Zhang L, Zhou Z, Zheng X, Liu G, Bu G, Fraser PE, Xu H, Zhang YW. Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology. Journal of Cell Science. PMID 26813789 DOI: 10.1242/Jcs.176792  0.111
2000 Zhuo M, Holtzman DM, Li Y, Osaka H, DeMaro J, Jacquin M, Bu G. Role of Tissue Plasminogen Activator Receptor LRP in Hippocampal Long-Term Potentiation The Journal of Neuroscience. 20: 542-549. DOI: 10.1523/JNEUROSCI.20-02-00542.2000  0.107
2018 Guo D, Xie W, Xiong P, Li H, Wang S, Chen G, Gao Y, Zhou J, Zhang Y, Bu G, Xue M, Zhang J. Cyclin-dependent kinase 5-mediated phosphorylation of chloride intracellular channel 4 promotes oxidative stress-induced neuronal death. Cell Death & Disease. 9: 951. PMID 30237421 DOI: 10.1038/s41419-018-0983-1  0.107
2022 Pantazis CB, Yang A, Lara E, McDonough JA, Blauwendraat C, Peng L, Oguro H, Kanaujiya J, Zou J, Sebesta D, Pratt G, Cross E, Blockwick J, Buxton P, Kinner-Bibeau L, ... ... Bu G, et al. A reference human induced pluripotent stem cell line for large-scale collaborative studies. Cell Stem Cell. 29: 1685-1702.e22. PMID 36459969 DOI: 10.1016/j.stem.2022.11.004  0.102
2023 Kuchenbecker LA, Tipton PW, Martens Y, Brier MR, Satyadev N, Dunham SR, Lazar EB, Dacquel MV, Henson RL, Bu G, Geschwind MD, Morris JC, Schindler SE, Herries E, Graff-Radford NR, et al. Diagnostic Utility of Cerebrospinal Fluid Biomarkers in Patients with Rapidly Progressive Dementia. Annals of Neurology. PMID 37897306 DOI: 10.1002/ana.26822  0.101
1992 Bu G, Morton PA, Schwartz AL. Identification and partial characterization by chemical cross-linking of a binding protein for tissue-type plasminogen activator (t-PA) on rat hepatoma cells: A plasminogen activator inhibitor type 1-independent t-PA receptor Journal of Biological Chemistry. 267: 15595-15602. PMID 1322401  0.098
2018 Pan G, Chen Z, Zheng H, Zhang Y, Xu H, Bu G, Zheng H, Li Y. Compensatory Mechanisms Modulate the Neuronal Excitability in a Kainic Acid-Induced Epilepsy Mouse Model. Frontiers in Neural Circuits. 12: 48. PMID 30008664 DOI: 10.3389/Fncir.2018.00048  0.095
1998 Guo Y, Yang Z, Bu G. Model of human nasal gland cells cultured in collagen gels Zhonghua Er Bi Yan Hou Ke Za Zhi. 33: 136-138. PMID 11717900  0.091
2009 Hayashi S, Yamamoto M, Tachibana K, Ueno Y, Bu G, Fukushima T. Mechanism of photofrin-enhanced ultrasound-induced human glioma cell death. Anticancer Research. 29: 897-905. PMID 19414325  0.087
2008 Zheng H, Shen X, Bu G, Luo Y. Effects of pH, temperature and enzyme-to-substrate ratio on the antigenicity of whey protein hydrolysates prepared by Alcalase International Dairy Journal. 18: 1028-1033. DOI: 10.1016/j.idairyj.2008.05.002  0.086
1993 Oxenrider KA, Bu G, Sitz TO. Adenosine analogs inhibit the guanine-7-methylation of mRNA cap structures Febs Letters. 316: 273-277. PMID 8422953 DOI: 10.1016/0014-5793(93)81307-L  0.086
2023 Shinohara M, Gheni G, Hitomi J, Bu G, Sato N. genotypes modify the obesity paradox in dementia. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 37414536 DOI: 10.1136/jnnp-2022-331034  0.085
2010 Bu G, Luo Y, Zhang Y, Chen F. Effects of fermentation by lactic acid bacteria on the antigenicity of bovine whey proteins Journal of the Science of Food and Agriculture. 90: 2015-2020. PMID 20583192 DOI: 10.1002/jsfa.4046  0.084
2008 Luo Y, Shen H, Pan D, Bu G. Gel properties of surimi from silver carp (Hypophthalmichthys molitrix) as affected by heat treatment and soy protein isolate Food Hydrocolloids. 22: 1513-1519. DOI: 10.1016/j.foodhyd.2007.10.003  0.084
2013 Bu G, Luo Y, Chen F, Liu K, Zhu T. Milk processing as a tool to reduce cow's milk allergenicity: a mini-review. Dairy Science & Technology. 93: 211-223. PMID 23626868 DOI: 10.1007/s13594-013-0113-x  0.082
2012 Liu K, Zhao Y, Chen F, Gu Z, Bu G. Purification, identification, and in vitro antioxidant activities of selenium-containing proteins from selenium-enriched brown rice European Food Research and Technology. 234: 61-68. DOI: 10.1007/s00217-011-1609-3  0.078
1999 Guo Y, Yang Z, Bu G. Floating culture of human nasal glandular cells Zhonghua Er Bi Yan Hou Ke Za Zhi. 34: 25-26. PMID 12764790  0.078
2022 Mielke MM, Dage JL, Frank RD, Algeciras-Schimnich A, Knopman DS, Lowe VJ, Bu G, Vemuri P, Graff-Radford J, Jack CR, Petersen RC. Author Correction: Performance of plasma phosphorylated tau 181 and 217 in the community. Nature Medicine. PMID 36216947 DOI: 10.1038/s41591-022-02066-w  0.075
2015 Bu G, Zhang N, Chen F. The influence of glycosylation on the antigenicity, allergenicity, and structural properties of 11S-lactose conjugates Food Research International. 76: 511-517. DOI: 10.1016/j.foodres.2015.08.004  0.069
2015 Wang H, Hara Y, Liu X, Reuben JM, Xie Y, Xu H, Bu G, Pei Y, Gupta V, Wu X. Detection and enumeration of circulating tumor cells based on their invasive property. Oncotarget. PMID 26247814 DOI: 10.18632/oncotarget.4454  0.068
2022 Qu W, Wang Z, Engelberg-Cook E, Yan D, Siddik AB, Bu G, Allickson JG, Kubrova E, Caplan AI, Hare JM, Ricordi C, Pepine CJ, Kurtzberg J, Pascual JM, Mallea JM, et al. Efficacy and Safety of MSC Cell Therapies for Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis. Stem Cells Translational Medicine. PMID 35640138 DOI: 10.1093/stcltm/szac032  0.063
2010 Bu G, Luo Y, Lu J, Zhang Y. Reduced antigenicity of β-lactoglobulin by conjugation with glucose through controlled Maillard reaction conditions Food and Agricultural Immunology. 21: 143-156. DOI: 10.1080/09540100903452122  0.063
2001 Zerbinatti C, Bu G. Bimonthly update. Genetics and molecular biology Current Opinion in Lipidology. 12: 77-79. PMID 11176206  0.059
2009 Bu G, Luo Y, Zheng Z, Zheng H. Effect of heat treatment on the antigenicity of bovine α-lactalbumin and β-lactoglobulin in whey protein isolate Food and Agricultural Immunology. 20: 195-206. DOI: 10.1080/09540100903026116  0.058
2014 Bu G, Xu H. Reviewer acknowledgement Molecular Neurodegeneration. DOI: 10.1186/1750-1326-9-9  0.056
2014 Zheng Z, Luo Y, Yao L, Lu J, Bu G. Effects of Maillard reaction conditions on the functional properties of WPI chitosan oligosaccharide conjugates. Journal of Food Science and Technology. 51: 3794-802. PMID 25477646 DOI: 10.1007/s13197-013-0946-6  0.056
2015 Bu GH, Zhang N, Chen FS. Antigenicity, allergenicity, and structural properties of soy protein isolate-xylose conjugates Modern Food Science and Technology. 31: 33-38 and 91. DOI: 10.13982/j.mfst.1673-9078.2015.11.006  0.056
2011 Zhang X, Bu G, Wu S, Xie Q. Research on brand equity of Automobile industry - Based on customer experience and modern service International Conference On Management and Service Science, Mass 2011. DOI: 10.1109/ICMSS.2011.5998834  0.054
1990 Bu G. Variation of sphenoidal sinuses in relation to sella turcica Chinese Medical Journal. 103: 324-325. PMID 2118043  0.054
2007 Bu G, Berbari EJ, Rubart M. Optical recording of single cardiomyocyte transmembrane potential in langendorff-perfused mouse hearts Computers in Cardiology. 34: 357-360. DOI: 10.1109/CIC.2007.4745495  0.053
2015 Cai J, Bu G, Li K. Seismic demand for eccentric wall structures subjected to pulse-like ground motions Zhongnan Daxue Xuebao (Ziran Kexue Ban)/Journal of Central South University (Science and Technology). 46: 4231-4239. DOI: 10.11817/j.issn.1672-7207.2015.11.034  0.053
2015 Cao L, Zhou J, Zhang J, Wu S, Yang X, Zhao X, Li H, Luo M, Yu Q, Lin G, Lin H, Xie J, Li P, Hu X, Zheng C, ... Bu G, et al. Cyclin-dependent kinase 5 decreases in gastric cancer and its nuclear accumulation suppresses gastric tumorigenesis. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 1419-28. PMID 25609066 DOI: 10.1158/1078-0432.Ccr-14-1950  0.05
2009 Bu G, Lu J, Zheng Z, Luo Y. Influence of Maillard reaction conditions on the antigenicity of bovine α-lactalbumin using response surface methsodology Journal of the Science of Food and Agriculture. 89: 2428-2434. DOI: 10.1002/jsfa.3741  0.049
2014 Bu G, Cai J, Zhou J, Li K. Seismic demand for eccentric wall structures subjected to velocity pulse-like ground motions Journal of Vibroengineering. 16: 1661-1671.  0.047
2018 Ross OA, Bu G. A novel link between trafficking and Lewy body disorders. The Lancet. Neurology. PMID 29887160 DOI: 10.1016/S1474-4422(18)30214-X  0.046
2013 Zhou J, Bu G, Wang H, Cai J. Modification of ductility reduction factor for vertically irregular structures subjected to pulse-like ground motions Advances in Structural Engineering. 16: 641-652. DOI: 10.1260/1369-4332.16.4.641  0.046
2021 Zhang R, Zhang C, Shu X, Yuan X, Li Y, Chen Q, Huang H, Zeng Q, Bu G, Li R, Li S, Chang M, Tang S. Effect of osteoporosis on adjacent segmental degeneration following posterior lumbar interbody fusion under whole body vibration. World Neurosurgery. PMID 34129985 DOI: 10.1016/j.wneu.2021.06.031  0.045
2009 Bu GX, Tan P, Zhou FL. Dynamic reliability analysis on stochastic structure with MTMD control Zhendong Yu Chongji/Journal of Vibration and Shock. 28: 119-123.  0.045
2009 Bu G, Adams H, Berbari EJ, Rubart M. Uniform action potential repolarization within the sarcolemma of in situ ventricular cardiomyocytes. Biophysical Journal. 96: 2532-46. PMID 19289075 DOI: 10.1016/J.Bpj.2008.12.3896  0.045
2009 Liu G, Zhao Y, Li L, Bu G, Shu P. Simulation of scroll expander used in low-temperature waste heat recovery system Hsi-An Chiao Tung Ta Hsueh/Journal of Xi'An Jiaotong University. 43: 88-91.  0.042
2013 Cai J, Wang H, Bu G. Study on the influence of multi-degree-of-freedom effect on ductility reduction factors for shear-type structure Journal of Earthquake Engineering and Engineering Vibration. 33: 204-211. DOI: 10.13197/j.eeev.2013.05.204.caij.026  0.042
2012 Wang M, Zhao Y, Cao F, Bu G, Wang Z. Simulation study on a novel vane-type expander with internal two-stage expansion process for R-410A refrigeration system International Journal of Refrigeration. 35: 757-771. DOI: 10.1016/j.ijrefrig.2011.11.014  0.041
1992 Bu G. Prevention of noise induced hearing loss in musicians of Chinese opera Zhonghua Er Bi Yan Hou Ke Za Zhi. 27: 73-75, 124. PMID 1419181  0.041
2008 Wang C, Yin Y, Wang X, Bu G. Improving the color yield of ultra-fine pigment printing on cotton fabric Aatcc Review. 8: 41-45.  0.041
1994 Li X, Bu G, Guo X. The flow-limiting segment (FS) of the nasal airway Zhonghua Er Bi Yan Hou Ke Za Zhi. 29: 48-49. PMID 8031604  0.04
1991 Wang J, Bu G. Studies of rhinitis medicamentosa Chinese Medical Journal. 104: 60-63. PMID 1879198  0.04
2009 Wang A, Bu G. Evaluation of high-tech zone technology innovation ability with unascertained measurement model 2009 International Conference On Information Management, Innovation Management and Industrial Engineering, Iciii 2009. 4: 242-245. DOI: 10.1109/ICIII.2009.519  0.04
2024 Cao L, Zhou J, Zhang J, Wu S, Yang X, Zhao X, Li H, Luo M, Yu Q, Lin G, Lin H, Xie J, Li P, Hu X, Zheng C, ... Bu G, et al. Editor's Note: Cyclin-Dependent Kinase 5 Decreases in Gastric Cancer and its Nuclear Accumulation Suppresses Gastric Tumorigenesis. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 30: 918. PMID 38362723 DOI: 10.1158/1078-0432.CCR-23-3968  0.039
2012 Guo X, Ma S, Bu G, Xu Z. Present application situation of DC system participating in power system stability control and discussion on position of its functions in security defense system Dianwang Jishu/Power System Technology. 36: 116-123.  0.039
2011 Chen J, Li Q, Liu C, Zhou P, Bu G, Wang J. Erratum to: NMR structure note: solution structure of the core domain of MESD that is essential for proper folding of LRP5/6 Journal of Biomolecular Nmr. 50: 101-101. DOI: 10.1007/S10858-011-9476-6  0.039
2006 Marzolo MP, Bu G. Morphogens, new passengers on lipoprotein particles. Current Opinion in Lipidology. 17: 202-4. PMID 16531760 DOI: 10.1097/01.mol.0000217905.28433.39  0.039
2012 Bu G, Wang C, Fu S, Tian A. Water-soluble cationic chitosan derivative to improve pigment-based inkjet printing and antibacterial properties for cellulose substrates Journal of Applied Polymer Science. 125: 1674-1680. DOI: 10.1002/app.34916  0.038
1994 Wang J, Bu G. Studies on the nasal absorption of gentamycin Zhonghua Er Bi Yan Hou Ke Za Zhi. 29: 134-136. PMID 7803102  0.038
2009 Guo X, Bu G, Ma S. A nonlinear controller with modulation signal for HVDC to improve power system stability 1st International Conference On Sustainable Power Generation and Supply, Supergen '09. DOI: 10.1109/SUPERGEN.2009.5347953  0.037
2006 Bu G, Berbari EJ. A single moving dipole model of ventricular depolarization. Biomedical Sciences Instrumentation. 42: 237-42. PMID 16817614  0.036
2012 Shen X, Yin Y, Bu G, Guo Q. Applicability analysis on simplified model of interphase power controllers Dianli Xitong Zidonghua/Automation of Electric Power Systems. 36: 64-69. DOI: 10.3969/j.issn.1000-1026.2012.02.012  0.036
2013 An H, Bu G, Guo M. [One case of laryngeal pleomorphic adenoma] Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi = Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery. 27: 492-493. PMID 23898619  0.035
2000 Wang J, Bu G. Influence of the nasal mucociliary system on intranasal drug administration Chinese Medical Journal. 113: 647-649. PMID 11776039  0.034
2013 He J, Sun H, Guo J, Bu G. Suppressing AC tie-line stochastic power fluctuation by HVDC power modulation control Zhongguo Dianji Gongcheng Xuebao/Proceedings of the Chinese Society of Electrical Engineering. 33: 93-98.  0.034
2000 Wang J, Bu G. Clinical observation of oral adenosine triposthate in treating rhinitis medicamentosa Chinese Medical Journal. 113: 349.  0.033
2012 Bu G, Wang L, Song B. Electrical and mechanical technology research of fully mechanized coal caving under aquifer Advanced Materials Research. 396: 198-204. DOI: 10.4028/www.scientific.net/AMR.396-398.198  0.032
2013 Wang H, Cai J, Bu G. Evaluation of strong column factors for RC frames based on seismic vulnerability analysis Advanced Materials Research. 639: 854-858. DOI: 10.4028/www.scientific.net/AMR.639-640.854  0.032
2009 Liu G, Zhao Y, Li L, Bu G, Shu P. Experiment on output characteristics of scroll expander in small power generation system with low-temperature waste heat Hsi-An Chiao Tung Ta Hsueh/Journal of Xi'An Jiaotong University. 43: 100-103.  0.032
2013 Shen X, Yin Y, Bu G, Ma S. Conditions analysis of parametric resonance between interphase power controller and associated power grid Dianli Xitong Zidonghua/Automation of Electric Power Systems. 37. DOI: 10.7500/AEPS201204147  0.032
2023 Zhao N, Bu G. A TREM2 antibody energizes microglia. Nature Neuroscience. PMID 36765163 DOI: 10.1038/s41593-023-01265-z  0.031
2016 Wang T, Wan L, Bu G, Zhang Y. Mechanism and calculation method study of DC system contributed short-circuit current with three-phase short-circuit fault on inverter side Dianwang Jishu/Power System Technology. 40: 1313-1319. DOI: 10.13335/j.1000-3673.pst.2016.05.004  0.031
1998 Akay M, Marsic I, Medl A, Bu G. A system for medical consultation and education using multimodal human/machine communication Ieee Transactions On Information Technology in Biomedicine. 2: 282-291. PMID 10719539  0.031
2011 Bu G. The comparative study of the effect of incentives and punishments in the corporation Lecture Notes in Electrical Engineering. 111: 81-85. DOI: 10.1007/978-3-642-24823-8_13  0.03
2010 Sun H, Tang Y, Bu G. Accuracy analysis of fixed voltage setpoint indices for voltage stability 2010 International Conference On Power System Technology: Technological Innovations Making Power Grid Smarter, Powercon2010. DOI: 10.1109/POWERCON.2010.5666511  0.03
2008 Bu G, Zhao C, Zuo D, Wang M. The influence of material removal on the modal change of blade Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 5315: 1038-1046. DOI: 10.1007/978-3-540-88518-4_111  0.03
2007 Huang Y, Ji N, Mao Y, Bu G. Design of die casting die for box part system based on Pro/E Tezhong Zhuzao Ji Youse Hejin/Special Casting and Nonferrous Alloys. 27: 451-453.  0.029
2011 Liu K, Zhao Y, Chen F, Gu Z, Bu G. Enhanced glutathione peroxidases (GPx) activity in young barley seedlings enriched with selenium African Journal of Biotechnology. 10: 11483-11487.  0.029
2002 Wang J, Bu G. Influence of intranasal medication on the structure of the nasal mucosa Chinese Medical Journal. 115: 617-619. PMID 12133312  0.028
2010 Lin W, Tang Y, Bu G, Shao Y. Voltage stability analysis of multi-infeed AC/DC power system based on multi-infeed short circuit ratio 2010 International Conference On Power System Technology: Technological Innovations Making Power Grid Smarter, Powercon2010. DOI: 10.1109/POWERCON.2010.5666123  0.028
2010 Bu G, Zhang B, Zhu R. The risk assessment during logistics project management based on fuzzy comprehensive evaluation Iclem 2010: Logistics For Sustained Economic Development - Infrastructure, Information, Integration - Proceedings of the 2010 International Conference of Logistics Engineering and Management. 387: 1150-1156. DOI: 10.1061/41139(387)158  0.028
2011 Bu GZ. Modeling approach of system of armament systems evolution assessment Xitong Fangzhen Xuebao / Journal of System Simulation. 23.  0.028
2006 Bu GZ. Study on the architecture and effectiveness for armament systems Xi Tong Gong Cheng Yu Dian Zi Ji Shu/Systems Engineering and Electronics. 28: 1544-1548.  0.028
1994 Wang J, Bu G. An experimental study on nasal absorption of gentamycin in dogs Chinese Medical Journal. 107: 219-221. PMID 8088184  0.027
2010 Zhu J, Tan P, Bu G, Zhou F. Analyzing seismic fragility of typical low-rise RC frame buildings Huazhong Keji Daxue Xuebao (Ziran Kexue Ban)/Journal of Huazhong University of Science and Technology (Natural Science Edition). 38.  0.027
2009 Guo X, Ma S, Bu G, Tang Y. Survey on coordinated control of multi-infeed DC systems Dianli Xitong Zidonghua/Automation of Electric Power Systems. 33: 9-15.  0.025
2015 Bu GQ, Mao ZX. Mimics simulation software for screw placement in pedicle screw fixation for treating severe lumbar facet joint degeneration Chinese Journal of Tissue Engineering Research. 19: 2745-2751. DOI: 10.3969/j.issn.2095-4344.2015.17.022  0.025
2014 An H, Guo M, Han X, Bu G. [Analysis of personality characteristics of sudden deafness patients] Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi = Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery. 28: 484-486. PMID 25026829  0.025
2011 Bu GZ. An approach to technology readiness assessment of armament system of systems Xitong Gongcheng Lilun Yu Shijian/System Engineering Theory and Practice. 31: 1994-2000.  0.025
2009 Zhao C, Sun J, Bu G. Five-axis machining tool vector control of impeller Key Engineering Materials. 407: 264-267. DOI: 10.4028/www.scientific.net/KEM.407-408.264  0.024
2003 Xu ZW, Bu GY. A theorem on grid access control Journal of Computer Science and Technology. 18: 515-522.  0.024
1989 Bu G, Nakano T. Some new clinical applications of rhinomanometry Zhonghua Er Bi Yan Hou Ke Za Zhi. 24: 326-328, 384. PMID 2485457  0.024
1994 Li X, Bu G, Yang Z. Visual loss due to intraorbital hemorrhage. A noteworthy clinical emergency Chinese Medical Journal. 107: 69-71. PMID 8187578  0.024
2008 Feng M, Wang X, Zhao C, Bu G. Application of high speed machining in impeller process Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 5315: 1030-1037. DOI: 10.1007/978-3-540-88518-4_110  0.024
2015 Dang L, Bu G. Study of athletic ability evaluation model for professional football teams based on the extension theory Chemical Engineering Transactions. 46: 457-462. DOI: 10.3303/CET1546077  0.024
2008 Bu G, Tavakoli AR, Entesari K. A 24 GHz indirect VCO in 0.18 μm CMOS technology 2008 European Microwave Integrated Circuit Conference, Eumic 2008. 71-74. DOI: 10.1109/EMICC.2008.4772231  0.023
2014 Cai J, Bu G, Yang C, Chen Q, Zuo Z. Calculation methods for inter-story drifts of building structures Advances in Structural Engineering. 17: 735-745. DOI: 10.1260/1369-4332.17.5.735  0.023
2014 Bu G, Cai J, Zhou J, Li K. Elasto-plastic seismic demand of general multi-story eccentric RC frame structures Tumu Gongcheng Xuebao/China Civil Engineering Journal. 47: 145-150.  0.022
2005 Bu GZ, Zhang YW. Study on models of torpedo synthetic conceptual design with MDO Binggong Xuebao/Acta Armamentarii. 26: 163-168.  0.022
2010 Zhou J, Bu G, Fang X. Seismic displacement ductility demand of vertically irregular structures subjected to velocity pulse-like ground motions Tumu Gongcheng Xuebao/China Civil Engineering Journal. 43: 148-155.  0.021
2009 Guo X, Ma S, Bu G, Tang X. A nonlinear decentralized controller for SVC considering supplementary control object Asia-Pacific Power and Energy Engineering Conference, Appeec. DOI: 10.1109/APPEEC.2009.4918086  0.021
2015 Qiu D, Bu G, Zhao B, Lin Z. Mesoporous silicon microspheres fabricated via in situ magnesiothermic reduction of silicon oxide as a high-performance anode material for lithium–ion batteries Journal of Solid State Electrochemistry. 19: 935-939. DOI: 10.1007/s10008-014-2693-7  0.02
2005 Song Y, Bu G, Zhang R. A fast method for probabilistic reliability assessment of bulk power system using FSOM neural network as system states filters Proceedings of the Ieee Power Engineering Society Transmission and Distribution Conference. 2005: 1-6. DOI: 10.1109/TDC.2005.1546789  0.02
1998 Zhang Q, Yang Z, Bu G. Surgery of advanced clival tumors Zhonghua Er Bi Yan Hou Ke Za Zhi. 33: 21-23. PMID 11498882  0.019
1998 Zhang Q, Yang Z, Bu G. Endoscopic transsphenoidal approach in surgical treatment of pituitary adenomas Zhonghua Er Bi Yan Hou Ke Za Zhi. 33: 97-99. PMID 11498863  0.019
2012 Shen X, Yin Y, Bu G, Guo Q. Research on modeling of dual output phase-shifting transformers Dianwang Jishu/Power System Technology. 36: 215-218.  0.018
2004 Bu G, Xu Z. Access control in semantic grid Future Generation Computer Systems. 20: 113-122. DOI: 10.1016/S0167-739X(03)00168-7  0.018
2011 Lu Y, Zhao Y, Bu G, Shu P. The integration of water vane pump and hydraulic vane motor for a small desalination system Desalination. 276: 60-65. DOI: 10.1016/j.desal.2011.03.023  0.018
2011 Bu G, Tan P, Zhou F. Optimal design of the TMD device based on cost-effectiveness criterion Tumu Gongcheng Xuebao/China Civil Engineering Journal. 44: 24-31.  0.017
2002 Throne RD, Olson LG, Bu G, Windle JR. A comparison of methods for estimating endocardial potentials from a noncontact probe Computers in Cardiology. 29: 309-311.  0.017
2002 Bu G, Throne RD, Olson LG, Windle JR. Analysis of the maximum a posteriori approach to the inverse problem of electrocardiography for different depolarization sequences Computers in Cardiology. 29: 493-496.  0.016
2006 Zuo D, Xu H, Bu G, Zhao C, Wang M. Residual stresses in Ti-6Al-4V high-speed-milled under stretching fixation Icpmt2006 - Progress of Machining Technology - Proceedings of the 8th International Conference On Progress of Machining Technology. 329-332.  0.016
2014 Bu GQ, Zhang SD. Neulen titanium plate fixation and spinal canal expansion bone grafting for cervical spondylosis: Half-year follow-up of healing rate of bone graft Chinese Journal of Tissue Engineering Research. 18: 3493-3497. DOI: 10.3969/j.issn.2095-4344.2014.22.009  0.016
2003 Bu G, Throne RD, Olson L, Windle J. The maximum a posteriori approach to the inverse problem of electrocardiography Biomedical Sciences Instrumentation. 39: 158-162. PMID 12724886  0.016
2002 Deng J, Ciplys D, Bu G, Shur M, Gaska R. Properties of surface acoustic waves in AlN and GaN Materials Research Society Symposium - Proceedings. 743: 455-460.  0.015
2013 He J, Cheng L, Bu G. Reliability assessment of composite power system with large-scale grid-integration of plug-in hybrid electric vehicles Dianwang Jishu/Power System Technology. 37: 899-905.  0.015
2003 Bu GZ, Zhang YW. Collaborative optimization model for large scale mechanical system Jixie Kexue Yu Jishu/Mechanical Science and Technology. 22: 540.  0.015
1994 Dong J, Bu GL. Care for patients with deep vein thrombosis in the leg treated by intravenous drugs Zhonghua Hu Li Za Zhi = Chinese Journal of Nursing. 29: 588-590. PMID 7614567  0.014
2023 Bu G, Zheng H. In memoriam of Huaxi Xu, PhD, 1964-2022. Molecular Neurodegeneration. 18: 6. PMID 36703200 DOI: 10.1186/s13024-022-00587-z  0.012
1992 Bu GX, Yang ZQ. Emergence of rhinoneurosurgery in China Chinese Medical Journal. 105: 77-80. PMID 1576876  0.011
2012 Tang Y, Bu G, Yi J. Analysis and lessons of the blackout in Indian power grid on July 30 and 31, 2012 Zhongguo Dianji Gongcheng Xuebao/Proceedings of the Chinese Society of Electrical Engineering. 32: 167-174.  0.01
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