| Year |
Citation |
Score |
| 2024 |
Manickasamy MK, Jayaprakash S, Girisa S, Kumar A, Lam HY, Okina E, Eng H, Alqahtani MS, Abbas M, Sethi G, Kumar AP, Kunnumakkara AB. Delineating the role of nuclear receptors in colorectal cancer, a focused review. Discover. Oncology. 15: 41. PMID 38372868 DOI: 10.1007/s12672-023-00808-x |
0.302 |
|
| 2023 |
Gupta N, Mohan CD, Shanmugam MK, Jung YY, Chinnathambi A, Alharbi SA, Ashrafizadeh M, Mahale M, Bender A, Kumar AP, Putti TC, Rangappa KS, Zhang X, Ahn KS, Sethi G. CXCR4 expression is elevated in TNBC patient derived samples and Z-guggulsterone abrogates tumor progression by targeting CXCL12/CXCR4 signaling axis in preclinical breast cancer model. Environmental Research. 232: 116335. PMID 37290620 DOI: 10.1016/j.envres.2023.116335 |
0.337 |
|
| 2023 |
Ang HL, Mohan CD, Shanmugam MK, Leong HC, Makvandi P, Rangappa KS, Bishayee A, Kumar AP, Sethi G. Mechanism of epithelial-mesenchymal transition in cancer and its regulation by natural compounds. Medicinal Research Reviews. PMID 36929669 DOI: 10.1002/med.21948 |
0.317 |
|
| 2022 |
Tuli HS, Rath P, Chauhan A, Ranjan A, Ramniwas S, Sak K, Aggarwal D, Kumar M, Dhama K, Lee EHC, Yap KC, Capinpin SM, Kumar AP. Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends. Biomolecules. 13. PMID 36671442 DOI: 10.3390/biom13010057 |
0.359 |
|
| 2022 |
Jayaprakash S, Hegde M, Girisa S, Alqahtani MS, Abbas M, Lee EHC, Yap KC, Sethi G, Kumar AP, Kunnumakkara AB. Demystifying the Functional Role of Nuclear Receptors in Esophageal Cancer. International Journal of Molecular Sciences. 23. PMID 36142861 DOI: 10.3390/ijms231810952 |
0.342 |
|
| 2022 |
Jung YY, Mohan CD, Eng H, Narula AS, Namjoshi OA, Blough BE, Rangappa KS, Sethi G, Kumar AP, Ahn KS. 2,3,5,6-Tetramethylpyrazine Targets Epithelial-Mesenchymal Transition by Abrogating Manganese Superoxide Dismutase Expression and TGFβ-Driven Signaling Cascades in Colon Cancer Cells. Biomolecules. 12. PMID 35883447 DOI: 10.3390/biom12070891 |
0.336 |
|
| 2022 |
Paskeh MDA, Entezari M, Mirzaei S, Zabolian A, Saleki H, Naghdi MJ, Sabet S, Khoshbakht MA, Hashemi M, Hushmandi K, Sethi G, Zarrabi A, Kumar AP, Tan SC, Papadakis M, et al. Emerging role of exosomes in cancer progression and tumor microenvironment remodeling. Journal of Hematology & Oncology. 15: 83. PMID 35765040 DOI: 10.1186/s13045-022-01305-4 |
0.336 |
|
| 2022 |
Jung YY, Chinnathambi A, Alahmadi TA, Alharbi SA, Kumar AP, Sethi G, Ahn KS. Fangchinoline targets epithelial-mesenchymal transition process by modulating activation of multiple cell-signaling pathways. Journal of Cellular Biochemistry. PMID 35621239 DOI: 10.1002/jcb.30279 |
0.323 |
|
| 2022 |
Paskeh MDA, Saebfar H, Mahabady MK, Orouei S, Hushmandi K, Entezari M, Hashemi M, Aref AR, Hamblin MR, Ang HL, Kumar AP, Zarrabi A, Samarghandian S. Overcoming doxorubicin resistance in cancer: siRNA-loaded nanoarchitectures for cancer gene therapy. Life Sciences. 120463. PMID 35259354 DOI: 10.1016/j.lfs.2022.120463 |
0.333 |
|
| 2022 |
Yang MH, Jung SH, Um JY, Kumar AP, Sethi G, Ahn KS. Daidzin targets epithelial-to-mesenchymal transition process by attenuating manganese superoxide dismutase expression and PI3K/Akt/mTOR activation in tumor cells. Life Sciences. 120395. PMID 35181309 DOI: 10.1016/j.lfs.2022.120395 |
0.307 |
|
| 2021 |
Loo SY, Syn NL, Koh AP, Teng JC, Deivasigamani A, Tan TZ, Thike AA, Vali S, Kapoor S, Wang X, Wang JW, Tan PH, Yip GW, Sethi G, Huang RY, ... ... Kumar AP, et al. Epigenetic derepression converts PPARγ into a druggable target in triple-negative and endocrine-resistant breast cancers. Cell Death Discovery. 7: 265. PMID 34580286 DOI: 10.1038/s41420-021-00635-5 |
0.321 |
|
| 2021 |
Ashrafizadeh M, Zarrabi A, Mirzaei S, Hashemi F, Samarghandian S, Zabolian A, Hushmandi K, Ang HL, Sethi G, Kumar AP, Ahn KS, Nabavi N, Khan H, Makvandi P, Varma RS. Use of Gallic acid for cancer treatment: Molecular mechanisms and improvement of efficacy by nanoformulations. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 112576. PMID 34571052 DOI: 10.1016/j.fct.2021.112576 |
0.326 |
|
| 2021 |
Mohan CD, Kim C, Siveen KS, Manu KA, Rangappa S, Chinnathambi A, Alharbi SA, Rangappa KS, Kumar AP, Ahn KS. Crocetin Imparts Antiproliferative Activity via Inhibiting STAT3 Signaling in Hepatocellular Carcinoma. Iubmb Life. PMID 34514729 DOI: 10.1002/iub.2555 |
0.318 |
|
| 2021 |
Ashrafizadeh M, Mirzaei S, Hashemi F, Zarrabi A, Zabolian A, Saleki H, Sharifzadeh SO, Soleymani L, Daneshi S, Hushmandi K, Khan H, Kumar AP, Aref AR, Samarghandian S. New insight towards development of paclitaxel and docetaxel resistance in cancer cells: EMT as a novel molecular mechanism and therapeutic possibilities. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 141: 111824. PMID 34175815 DOI: 10.1016/j.biopha.2021.111824 |
0.361 |
|
| 2021 |
Sikka S, Shanmugam MK, Siveen KS, Ong TH, Yang MH, Lee JH, Rajendran P, Chinnathambi A, Alharbi SA, Alahmadi TA, Vali S, Kumar AP, Sethi G, Wang L, Hui KM, et al. Diosgenin attenuates tumor growth and metastasis in transgenic prostate cancer mouse model by negatively regulating both NF-κB/STAT3 signaling cascades. European Journal of Pharmacology. 174274. PMID 34146587 DOI: 10.1016/j.ejphar.2021.174274 |
0.31 |
|
| 2021 |
Mirzaei S, Zarrabi A, Hashemi F, Zabolian A, Saleki H, Azami N, Hamzehlou S, Farahani MV, Hushmandi K, Ashrafizadeh M, Khan H, Kumar AP. Nrf2 Signaling Pathway in Chemoprotection and Doxorubicin Resistance: Potential Application in Drug Discovery. Antioxidants (Basel, Switzerland). 10. PMID 33652780 DOI: 10.3390/antiox10030349 |
0.304 |
|
| 2021 |
Ang HL, Yuan Y, Lai X, Tan TZ, Wang L, Huang BB, Pandey V, Huang RY, Lobie PE, Goh BC, Sethi G, Yap CT, Chan CW, Lee SC, Kumar AP. Putting the BRK on breast cancer: From molecular target to therapeutics. Theranostics. 11: 1115-1128. PMID 33391524 DOI: 10.7150/thno.49716 |
0.315 |
|
| 2020 |
Wang Y, Chiou YS, Chong QY, Zhang M, Rangappa KS, Ma L, Zhu T, Kumar AP, Huang RY, Pandey V, Basappa, Lobie PE. Pharmacological Inhibition of BAD Ser99 Phosphorylation Enhances the Efficacy of Cisplatin in Ovarian Cancer by Inhibition of Cancer Stem Cell-like Behavior. Acs Pharmacology & Translational Science. 3: 1083-1099. PMID 33344891 DOI: 10.1021/acsptsci.0c00064 |
0.334 |
|
| 2020 |
Garg M, Shanmugam MK, Bhardwaj V, Goel A, Gupta R, Sharma A, Baligar P, Kumar AP, Goh BC, Wang L, Sethi G. The pleiotropic role of transcription factor STAT3 in oncogenesis and its targeting through natural products for cancer prevention and therapy. Medicinal Research Reviews. PMID 33289118 DOI: 10.1002/med.21761 |
0.305 |
|
| 2020 |
Ashrafizadeh M, Zarrabi A, Hashemi F, Zabolian A, Saleki H, Bagherian M, Azami N, Bejandi AK, Hushmandi K, Ang HL, Makvandi P, Khan H, Kumar AP. Polychemotherapy with Curcumin and Doxorubicin via Biological Nanoplatforms: Enhancing Antitumor Activity. Pharmaceutics. 12. PMID 33187385 DOI: 10.3390/pharmaceutics12111084 |
0.379 |
|
| 2020 |
Hwang ST, Yang MH, Kumar AP, Sethi G, Ahn KS. Corilagin Represses Epithelial to Mesenchymal Transition Process Through Modulating Wnt/β-Catenin Signaling Cascade. Biomolecules. 10. PMID 33027960 DOI: 10.3390/biom10101406 |
0.309 |
|
| 2020 |
Moghadam ER, Ang HL, Asnaf SE, Zabolian A, Saleki H, Yavari M, Esmaeili H, Zarrabi A, Ashrafizadeh M, Kumar AP. Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives. Biomolecules. 10. PMID 32992587 DOI: 10.3390/biom10101374 |
0.322 |
|
| 2020 |
Ashrafizadeh M, Najafi M, Ang HL, Moghadam ER, Mahabady MK, Zabolian A, Jafaripour L, Bejandi AK, Hushmandi K, Saleki H, Zarrabi A, Kumar AP. PTEN, a Barrier for Proliferation and Metastasis of Gastric Cancer Cells: From Molecular Pathways to Targeting and Regulation. Biomedicines. 8. PMID 32756305 DOI: 10.3390/biomedicines8080264 |
0.376 |
|
| 2020 |
Harsha C, Banik K, Ang HL, Girisa S, Vikkurthi R, Parama D, Rana V, Shabnam B, Khatoon E, Kumar AP, Kunnumakkara AB. Targeting AKT/mTOR in Oral Cancer: Mechanisms and Advances in Clinical Trials. International Journal of Molecular Sciences. 21. PMID 32384682 DOI: 10.3390/ijms21093285 |
0.332 |
|
| 2020 |
Ong MS, Deng S, Halim CE, Cai W, Tan TZ, Huang RY, Sethi G, Hooi SC, Kumar AP, Yap CT. Cytoskeletal Proteins in Cancer and Intracellular Stress: A Therapeutic Perspective. Cancers. 12. PMID 31963677 DOI: 10.3390/Cancers12010238 |
0.379 |
|
| 2020 |
Lai X, Wang T, Tan TZ, Casey PJ, Hong W, Sudol M, Tergaonkar V, Lee SC, Kumar AP. Abstract A28: DEAD-box RNA helicase DP103 enhances YAP sumoylation for YAP-TEAD dependence and statin sensitivity in triple-negative breast cancer Molecular Cancer Research. 18. DOI: 10.1158/1557-3125.Hippo19-A28 |
0.443 |
|
| 2020 |
Malhotra A, Bansal R, Halim CE, Yap CT, Sethi G, Kumar AP, Bishnoi M, Yadav K. Novel amide analogues of quinazoline carboxylate display selective antiproliferative activity and potent EGFR inhibition Medicinal Chemistry Research. 1-11. DOI: 10.1007/S00044-020-02634-0 |
0.438 |
|
| 2019 |
Khattar E, Maung KZY, Chew CL, Ghosh A, Mok MMH, Lee P, Zhang J, Chor WHJ, Cildir G, Wang CQ, Mohd-Ismail NK, Chin DWL, Lee SC, Yang H, Shin YJ, ... ... Kumar AP, et al. Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy. Nature Communications. 10: 5349. PMID 31836706 DOI: 10.1038/S41467-019-13082-9 |
0.317 |
|
| 2019 |
Reddy D, Kumavath R, Tan TZ, Ampasala DR, Kumar AP. Peruvoside targets apoptosis and autophagy through MAPK Wnt/β-catenin and PI3K/AKT/mTOR signaling pathways in human cancers. Life Sciences. 241: 117147. PMID 31830480 DOI: 10.1016/J.Lfs.2019.117147 |
0.401 |
|
| 2019 |
Bordoloi D, Monisha J, Roy NK, Padmavathi G, Banik K, Harsha C, Wang H, Kumar AP, Arfuso F, Kunnumakkara AB. An Investigation on the Therapeutic Potential of Butein, A Tretrahydroxychalcone Against Human Oral Squamous Cell Carcinoma. Asian Pacific Journal of Cancer Prevention : Apjcp. 20: 3437-3446. PMID 31759370 DOI: 10.31557/Apjcp.2019.20.11.3437 |
0.408 |
|
| 2019 |
Sim WJ, Iyengar PV, Lama D, Lui SKL, Ng HC, Haviv-Shapira L, Domany E, Kappei D, Tan TZ, Saei A, Jaynes PW, Verma CS, Kumar AP, Rouanne M, Ha HK, et al. Author Correction: c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression. Nature Communications. 10: 5148. PMID 31704935 DOI: 10.1038/S41467-019-13095-4 |
0.323 |
|
| 2019 |
Poh HM, Chiou YS, Chong QY, Chen RM, Rangappa KS, Ma L, Zhu T, Kumar AP, Pandey V, Lee SC, Lobie PE. Inhibition of TFF3 Enhances Sensitivity-and Overcomes Acquired Resistance-to Doxorubicin in Estrogen Receptor-Positive Mammary Carcinoma. Cancers. 11. PMID 31658702 DOI: 10.3390/Cancers11101528 |
0.341 |
|
| 2019 |
Sim WJ, Iyengar PV, Lama D, Lui SKL, Ng HC, Haviv-Shapira L, Domany E, Kappei D, Tan TZ, Saie A, Jaynes PW, Verma CS, Kumar AP, Rouanne M, Ha HK, et al. c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression. Nature Communications. 10: 4349. PMID 31554791 DOI: 10.1038/S41467-019-12241-2 |
0.418 |
|
| 2019 |
Halim CE, Xinjing SL, Fan L, Bailey Vitarbo J, Arfuso F, Tan CH, Narula AS, Kumar AP, Sethi G, Ahn KS. Anti-cancer effects of oxymatrine are mediated through multiple molecular mechanism(s) in tumor models. Pharmacological Research. 104327. PMID 31283981 DOI: 10.1016/J.Phrs.2019.104327 |
0.48 |
|
| 2019 |
Roy NK, Monisha J, Padmavathi G, Lalhruaitluanga H, Kumar NS, Singh AK, Bordoloi D, Baruah MN, Ahmed GN, Longkumar I, Arfuso F, Kumar AP, Kunnumakkara AB. Isoform-Specific Role of Akt in Oral Squamous Cell Carcinoma. Biomolecules. 9. PMID 31252679 DOI: 10.3390/biom9070253 |
0.337 |
|
| 2019 |
Varughese RS, Lam WS, Marican AABH, Viganeshwari SH, Bhave AS, Syn NL, Wang J, Wong AL, Kumar AP, Lobie PE, Lee SC, Sethi G, Goh BC, Wang L. Biopharmacological considerations for accelerating drug development of deguelin, a rotenoid with potent chemotherapeutic and chemopreventive potential. Cancer. PMID 30933320 DOI: 10.1002/Cncr.32069 |
0.42 |
|
| 2019 |
Mishra S, Verma SS, Rai V, Awasthee N, Chava S, Hui KM, Kumar AP, Challagundla KB, Sethi G, Gupta SC. Long non-coding RNAs are emerging targets of phytochemicals for cancer and other chronic diseases. Cellular and Molecular Life Sciences : Cmls. PMID 30879091 DOI: 10.1007/S00018-019-03053-0 |
0.38 |
|
| 2019 |
Sailo BL, Banik K, Girisa S, Bordoloi D, Fan L, Halim CE, Wang H, Kumar AP, Zheng D, Mao X, Sethi G, Kunnumakkara AB. FBXW7 in Cancer: What Has Been Unraveled Thus Far? Cancers. 11. PMID 30791487 DOI: 10.3390/cancers11020246 |
0.342 |
|
| 2019 |
Deng S, Shanmugam MK, Kumar AP, Yap CT, Sethi G, Bishayee A. Targeting autophagy using natural compounds for cancer prevention and therapy. Cancer. PMID 30748003 DOI: 10.1002/Cncr.31978 |
0.408 |
|
| 2019 |
Ma Z, Wang YY, Xin HW, Wang L, Arfuso F, Dharmarajan A, Kumar AP, Wang H, Ru Tang F, Warrier S, Tergaonkar V, Sethi G. The Expanding Roles of Long Non-coding RNAs in the Regulation of Cancer Stem Cells. The International Journal of Biochemistry & Cell Biology. PMID 30630112 DOI: 10.1016/J.Biocel.2019.01.003 |
0.393 |
|
| 2019 |
Poh H, Chong Q, Chen R, Pandey V, Salundi B, Kumar A, Lee S, Lobie P. Abstract P6-20-09: Pharmacological inhibition of TFF3 enhances chemo-sensitivity and overcomes acquired resistance in breast cancer Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-P6-20-09 |
0.357 |
|
| 2019 |
Kanchi M, Hirpara J, Sachaphibulkij K, Tan T, Dietzel H, Lim L, Huang R, Pervaiz S, Neuzil J, Kumar A. Abstract P6-18-20: Targeting mitochondrial function for the treatment of triple negative breast cancer: Development of a small molecule inhibitor against mitochondrial STAT3 Cancer Research. 79. DOI: 10.1158/1538-7445.Sabcs18-P6-18-20 |
0.412 |
|
| 2018 |
Shanmugam MK, Ahn KS, Hsu A, Woo CC, Yuan Y, Tan KHB, Chinnathambi A, Alahmadi TA, Alharbi SA, Koh APF, Arfuso F, Huang RY, Lim LHK, Sethi G, Kumar AP. Thymoquinone Inhibits Bone Metastasis of Breast Cancer Cells Through Abrogation of the CXCR4 Signaling Axis. Frontiers in Pharmacology. 9: 1294. PMID 30564115 DOI: 10.3389/Fphar.2018.01294 |
0.465 |
|
| 2018 |
Mohan CD, Bharathkumar H, Dukanya, Rangappa S, Shanmugam MK, Chinnathambi A, Alharbi SA, Alahmadi TA, Bhattacharjee A, Lobie PE, Deivasigamani A, Hui KM, Sethi G, Basappa, Rangappa KS, ... Kumar AP, et al. N-Substituted Pyrido-1,4-Oxazin-3-Ones Induce Apoptosis of Hepatocellular Carcinoma Cells by Targeting NF-κB Signaling Pathway. Frontiers in Pharmacology. 9: 1125. PMID 30455641 DOI: 10.3389/Fphar.2018.01125 |
0.396 |
|
| 2018 |
Arora L, Kumar AP, Arfuso F, Chng WJ, Sethi G. The Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological Malignancies. Cancers. 10. PMID 30217007 DOI: 10.3390/cancers10090327 |
0.321 |
|
| 2018 |
Ranaware AM, Banik K, Deshpande V, Padmavathi G, Roy NK, Sethi G, Fan L, Kumar AP, Kunnumakkara AB. Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer. International Journal of Molecular Sciences. 19. PMID 30103472 DOI: 10.3390/ijms19082362 |
0.3 |
|
| 2018 |
Monisha J, Roy NK, Padmavathi G, Banik K, Bordoloi D, Khwairakpam AD, Arfuso F, Chinnathambi A, Alahmadi TA, Alharbi SA, Sethi G, Kumar AP, Kunnumakkara AB. NGAL is Downregulated in Oral Squamous Cell Carcinoma and Leads to Increased Survival, Proliferation, Migration and Chemoresistance. Cancers. 10. PMID 29996471 DOI: 10.3390/cancers10070228 |
0.345 |
|
| 2018 |
Kim C, Lee SG, Yang WM, Arfuso F, Um JY, Kumar AP, Bian J, Sethi G, Ahn KS. Formononetin-induced oxidative stress abrogates the activation of STAT3/5 signaling axis and suppresses the tumor growth in multiple myeloma preclinical model. Cancer Letters. PMID 29857127 DOI: 10.1016/J.Canlet.2018.05.038 |
0.477 |
|
| 2018 |
Sethi G, Shanmugam MK, Warrier S, Merarchi M, Arfuso F, Kumar AP, Bishayee A. Pro-Apoptotic and Anti-Cancer Properties of Diosgenin: A Comprehensive and Critical Review. Nutrients. 10. PMID 29783752 DOI: 10.3390/Nu10050645 |
0.435 |
|
| 2018 |
Shanmugam MK, Ahn KS, Lee JH, Kannaiyan R, Mustafa N, Manu KA, Siveen KS, Sethi G, Chng WJ, Kumar AP. Celastrol Attenuates the Invasion and Migration and Augments the Anticancer Effects of Bortezomib in a Xenograft Mouse Model of Multiple Myeloma. Frontiers in Pharmacology. 9: 365. PMID 29773987 DOI: 10.3389/Fphar.2018.00365 |
0.423 |
|
| 2018 |
Shanmugam MK, Shen H, Tang FR, Arfuso F, Rajesh M, Wang L, Kumar AP, Jinsong B, Cher GB, Bishayee A, Sethi G. Potential role of genipin in cancer therapy. Pharmacological Research. PMID 29758279 DOI: 10.1016/j.phrs.2018.05.007 |
0.312 |
|
| 2018 |
Khwairakpam AD, Bordoloi D, Thakur KK, Monisha J, Arfuso F, Sethi G, Mishra S, Kumar AP, Kunnumakkara AB. Possible use of Punica granatum (Pomegranate) in cancer therapy. Pharmacological Research. PMID 29729421 DOI: 10.1016/J.Phrs.2018.04.021 |
0.45 |
|
| 2018 |
Shanmugam MK, Arfuso F, Arumugam S, Chinnathambi A, Bian J, Warrier S, Wang LZ, Kumar AP, Ahn KS, Sethi G, Lakshmanan M. Correction: Role of novel histone modifications in cancer. Oncotarget. 9: 19460. PMID 29722359 DOI: 10.18632/Oncotarget.25152 |
0.314 |
|
| 2018 |
Mohan CD, Anilkumar NC, Rangappa S, Shanmugam MK, Mishra S, Chinnathambi A, Alharbi SA, Bhattacharjee A, Sethi G, Kumar AP, Basappa, Rangappa KS. Novel 1,3,4-Oxadiazole Induces Anticancer Activity by Targeting NF-κB in Hepatocellular Carcinoma Cells. Frontiers in Oncology. 8: 42. PMID 29616186 DOI: 10.3389/Fonc.2018.00042 |
0.421 |
|
| 2018 |
Shanmugam MK, Arfuso F, Arumugam S, Chinnathambi A, Jinsong B, Warrier S, Wang LZ, Kumar AP, Ahn KS, Sethi G, Lakshmanan M. Role of novel histone modifications in cancer. Oncotarget. 9: 11414-11426. PMID 29541423 DOI: 10.18632/Oncotarget.23356 |
0.332 |
|
| 2018 |
Cheong DHJ, Arfuso F, Sethi G, Wang L, Hui KM, Kumar AP, Tran T. Molecular targets and anti-cancer potential of escin. Cancer Letters. PMID 29474858 DOI: 10.1016/J.Canlet.2018.02.027 |
0.459 |
|
| 2018 |
Manu KA, Shanmugam MK, Ramachandran L, Li F, Siveen KS, Chinnathambi A, Zayed ME, Alharbi SA, Arfuso F, Kumar AP, Ahn KS, Sethi G. Corrigendum on "Isorhamnetin augments the anti-tumor effect of capeciatbine through the negative regulation of NF-κB signaling cascade in gastric cancer" [Cancer Lett. 363 (1) (2015) 28-36]. Cancer Letters. PMID 29338890 DOI: 10.1016/J.Canlet.2018.01.003 |
0.422 |
|
| 2018 |
Ong MS, Cai W, Tan TZ, Huang RY, Hooi SC, Yap CT, Kumar AP. Long Non-coding RNA Landscape in Colorectal Cancer Rna & Disease. 5. DOI: 10.14800/Rd.3 |
0.384 |
|
| 2017 |
Moraes LA, Kar S, Foo SL, Gu T, Toh YQ, Ampomah PB, Sachaphibulkij K, Yap G, Zharkova O, Lukman HM, Fairhurst AM, Kumar AP, Lim LHK. Annexin-A1 enhances breast cancer growth and migration by promoting alternative macrophage polarization in the tumour microenvironment. Scientific Reports. 7: 17925. PMID 29263330 DOI: 10.1038/S41598-017-17622-5 |
0.37 |
|
| 2017 |
Singh SS, Vats S, Chia AY, Tan TZ, Deng S, Ong MS, Arfuso F, Yap CT, Goh BC, Sethi G, Huang RY, Shen HM, Manjithaya R, Kumar AP. Dual role of autophagy in hallmarks of cancer. Oncogene. PMID 29255248 DOI: 10.1038/S41388-017-0046-6 |
0.424 |
|
| 2017 |
Banik K, Harsha C, Bordoloi D, Lalduhsaki Sailo B, Sethi G, Leong HC, Arfuso F, Mishra S, Wang L, Kumar AP, Kunnumakkara AB. Therapeutic potential of gambogic acid, a caged xanthone, to target cancer. Cancer Letters. PMID 29246645 DOI: 10.1016/J.Canlet.2017.12.014 |
0.416 |
|
| 2017 |
Ko JH, Sethi G, Um JY, Shanmugam MK, Arfuso F, Kumar AP, Bishayee A, Ahn KS. The Role of Resveratrol in Cancer Therapy. International Journal of Molecular Sciences. 18. PMID 29194365 DOI: 10.3390/Ijms18122589 |
0.436 |
|
| 2017 |
Shanmugam MK, Arfuso F, Kumar AP, Wang L, Goh BC, Ahn KS, Bishayee A, Sethi G. Modulation of diverse oncogenic transcription factors by thymoquinone, an essential oil compound isolated from the seeds of Nigella sativa Linn. Pharmacological Research. PMID 29162539 DOI: 10.1016/j.phrs.2017.11.023 |
0.351 |
|
| 2017 |
Wang C, Kar S, Lai X, Cai W, Arfuso F, Sethi G, Lobie PE, Goh BC, Lim LHK, Hartman M, Chan CW, Lee SC, Tan SH, Kumar AP. Triple negative breast cancer in Asia: An insider's view. Cancer Treatment Reviews. 62: 29-38. PMID 29154023 DOI: 10.1016/J.Ctrv.2017.10.014 |
0.354 |
|
| 2017 |
Sethi G, Shanmugam MK, Kumar AP. SREBP-1c as a molecular bridge between lipogenesis and cell cycle progression of clear cell renal carcinoma. Bioscience Reports. PMID 29138263 DOI: 10.1042/Bsr20171270 |
0.339 |
|
| 2017 |
Thirunavukkarasan M, Wang C, Rao A, Hind T, Teo YR, Siddiquee AA, Goghari MAI, Kumar AP, Herr DR. Short-chain fatty acid receptors inhibit invasive phenotypes in breast cancer cells. Plos One. 12: e0186334. PMID 29049318 DOI: 10.1371/Journal.Pone.0186334 |
0.401 |
|
| 2017 |
Chen L, Yuan Y, Kar S, Kanchi MM, Arora S, Kim JE, Koh PF, Yousef E, Samy RP, Shanmugam MK, Tan TZ, Shin SW, Arfuso F, Shen HM, Yang H, ... ... Kumar AP, et al. PPARγ Ligand-induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers. Molecular Cancer Therapeutics. PMID 29021293 DOI: 10.1158/1535-7163.Mct-16-0739 |
0.318 |
|
| 2017 |
Chen L, Yuan Y, Kar S, Kanchi MM, Arora S, Kim JE, Koh PF, Yousef E, Samy RP, Shanmugam MK, Tan TZ, Shin SW, Arfuso F, Shen HM, Yang H, ... ... Kumar AP, et al. PPARγ Ligand-induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple Negative Breast Cancers. Molecular Cancer Therapeutics. PMID 28811325 DOI: 10.1158/1535-7163.MCT-16-0739 |
0.316 |
|
| 2017 |
Ong MS, Cai W, Yuan Y, Leong HC, Tan TZ, Mohammad A, You ML, Arfuso F, Goh BC, Warrier S, Sethi G, Tolwinski NS, Lobie PE, Yap CT, Hooi SC, ... ... Kumar AP, et al. "Lnc"-ing Wnt in Female Reproductive Cancers: Therapeutic Potential of Long Non-coding RNAs in Wnt Signaling. British Journal of Pharmacology. PMID 28736855 DOI: 10.1111/Bph.13958 |
0.397 |
|
| 2017 |
Shanmugam MK, Warrier S, Kumar AP, Sethi G, Arfuso F. Potential role of natural compounds as anti-angiogenic agents in cancer. Current Vascular Pharmacology. PMID 28707601 DOI: 10.2174/1570161115666170713094319 |
0.394 |
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| 2017 |
Jahn A, Rane G, Paszkowski-Rogacz M, Sayols S, Bluhm A, Han CT, Draškovič I, Londoño-Vallejo JA, Kumar AP, Buchholz F, Butter F, Kappei D. ZBTB48 is both a vertebrate telomere-binding protein and a transcriptional activator. Embo Reports. PMID 28500257 DOI: 10.15252/Embr.201744095 |
0.326 |
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| 2017 |
Min-Wen JC, Yan-Jiang BC, Mishra S, Dai X, Magae J, Shyh-Chang N, Kumar AP, Sethi G. Molecular Targets of Ascochlorin and Its Derivatives for Cancer Therapy. Advances in Protein Chemistry and Structural Biology. 108: 199-225. PMID 28427561 DOI: 10.1016/Bs.Apcsb.2017.01.001 |
0.37 |
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| 2017 |
Bhuvanalakshmi G, Basappa, Rangappa KS, Dharmarajan A, Sethi G, Kumar AP, Warrier S. Breast Cancer Stem-Like Cells Are Inhibited by Diosgenin, a Steroidal Saponin, by the Attenuation of the Wnt β-Catenin Signaling via the Wnt Antagonist Secreted Frizzled Related Protein-4. Frontiers in Pharmacology. 8: 124. PMID 28373842 DOI: 10.3389/Fphar.2017.00124 |
0.438 |
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| 2017 |
Dai X, Wang L, Deivasigamni A, Looi CY, Karthikeyan C, Trivedi P, Chinnathambi A, Alharbi SA, Arfuso F, Dharmarajan A, Goh BC, Hui KM, Kumar AP, Mustafa MR, Sethi G. A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma. Oncotarget. PMID 28086233 DOI: 10.18632/Oncotarget.14606 |
0.384 |
|
| 2016 |
Kumavath R, Azad M, Devarapalli P, Tiwari S, Kar S, Barh D, Azevedo V, Kumar AP. Novel aromatase inhibitors selection using induced fit docking and extra precision methods: Potential clinical use in ER-alpha-positive breast cancer. Bioinformation. 12: 324-331. PMID 28293075 DOI: 10.6026/97320630012324 |
0.395 |
|
| 2016 |
Zhang J, Sikka S, Siveen KS, Lee JH, Um JY, Kumar AP, Chinnathambi A, Alharbi SA, Basappa, Rangappa KS, Sethi G, Ahn KS. Cardamonin represses proliferation, invasion, and causes apoptosis through the modulation of signal transducer and activator of transcription 3 pathway in prostate cancer. Apoptosis : An International Journal On Programmed Cell Death. PMID 27900636 DOI: 10.1007/S10495-016-1313-7 |
0.423 |
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| 2016 |
Dai X, Ahn KS, Wang LZ, Kim C, Deivasigamni A, Arfuso F, Um JY, Kumar AP, Chang YC, Kumar D, Kundu GC, Magae J, Goh BC, Hui KM, Sethi G. Ascochlorin enhances the sensitivity of doxorubicin leading to the reversal of epithelial-to-mesenchymal transition in hepatocellular carcinoma. Molecular Cancer Therapeutics. PMID 27765853 DOI: 10.1158/1535-7163.Mct-16-0391 |
0.406 |
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| 2016 |
Sulaiman NB, Mohan CD, Basappa S, Pandey V, Rangappa S, Bharathkumar H, Kumar AP, Lobie PE, Rangappa KS. An azaspirane derivative suppresses growth and induces apoptosis of ER-positive and ER-negative breast cancer cells through the modulation of JAK2/STAT3 signaling pathway. International Journal of Oncology. PMID 27500741 DOI: 10.3892/Ijo.2016.3615 |
0.445 |
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| 2016 |
Loo SY, Hirpara J, Pandey V, Tuan ZT, Yap CT, Lobie PE, Thiery JP, Goh BC, Pervaiz S, Clement MV, Kumar AP. MnSOD Expression Regulates the Switch between an Epithelial to a Mesenchymal-like Phenotype in Mammary Carcinoma. Antioxidants & Redox Signaling. PMID 27400860 DOI: 10.1089/Ars.2015.6524 |
0.355 |
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| 2016 |
Tochhawng L, Deng S, Pugalenthi G, Kumar AP, Lim KH, Yang H, Hooi SC, Goh YC, Maciver SK, Pervaiz S, Yap CT. Gelsolin-Cu/ZnSOD interaction alters intracellular reactive oxygen species levels to promote cancer cell invasion. Oncotarget. PMID 27391159 DOI: 10.18632/Oncotarget.10451 |
0.415 |
|
| 2016 |
Kothapalli R, Sivaraman Siveen K, Tan TZ, Paul Thiery J, Kumar AP, Sethi G, Swaminathan K. Functional characterization of selective exosite-binding inhibitors of matrix metalloproteinase-13 (MMP-13) - experimental validation in human breast and colon cancer. Bioscience, Biotechnology, and Biochemistry. 1-10. PMID 27362887 DOI: 10.1080/09168451.2016.1200456 |
0.352 |
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| 2016 |
Yuan Y, Anbalagan D, Lee LH, Ramar SP, Shanmugam MK, Kumar AP, Sethi G, Lobie PE, Lim LH. ANXA1 inhibits miRNA-196a in a negative feedback loop through NF-kB and C-Myc to reduce breast cancer proliferation. Oncotarget. PMID 27105503 DOI: 10.18632/Oncotarget.8875 |
0.398 |
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| 2016 |
Roy NK, Deka A, Bordoloi D, Mishra S, Kumar AP, Sethi G, Kunnumakkara AB. The potential role of boswellic acids in cancer prevention and treatment. Cancer Letters. PMID 27091399 DOI: 10.1016/J.Canlet.2016.04.017 |
0.415 |
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| 2016 |
Huang B, Deng S, Loo SY, Datta A, Yap YL, Yan B, Ooi CH, Dinh TD, Zhuo J, Tochhawng L, Gopinadhan S, Jegadeesan T, Tan P, Salto-Tellez M, Yong WP, ... ... Kumar AP, et al. Gelsolin-mediated activation of PI3K/Akt pathway is crucial for hepatocyte growth factor-induced cell scattering in gastric carcinoma. Oncotarget. PMID 27058427 DOI: 10.18632/Oncotarget.8603 |
0.35 |
|
| 2016 |
Shanmugam MK, Lee JH, Chai EZ, Mathi KM, Kar S, Arfuso F, Dharmarajan A, Kumar AP, Samy RP, Looi CY, Mustafa MR, Tergaonkar V, Bishayee A, Ahn KS, Sethi G. Cancer prevention and therapy through the modulation of transcription factors by bioactive natural compounds. Seminars in Cancer Biology. PMID 27038646 DOI: 10.1016/J.Semcancer.2016.03.005 |
0.437 |
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| 2016 |
Deng S, Ong MS, Ng ZX, Jegadeesan T, So JBY, Kumar AP, Yap CT. Gelsolin: A new insight of its role on gastric cancer dissemination Rna & Disease. 3. DOI: 10.14800/Rd.1439 |
0.398 |
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| 2016 |
Cai W, Cheong J, Edison E, Banerjee A, Tan T, Gaboury L, Yousef E, Thiery J, Lobie P, Virshup D, Yap C, Kumar A. Abstract P4-08-03: DEAD-box RNA helicase DP103 as a novel regulator of Wnt/β-catenin signaling pathway and promotes cancer stem cell-like behavior in triple negative breast cancers Cancer Research. 76. DOI: 10.1158/1538-7445.Sabcs15-P4-08-03 |
0.417 |
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| 2015 |
Shin EM, Osato M, Kumar AP, Tergaonkar V. RNA helicase DP103 and TAK1: a new connection in cancer. Molecular & Cellular Oncology. 2: e985911. PMID 27308465 DOI: 10.4161/23723556.2014.985911 |
0.305 |
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| 2015 |
Zhang J, Ahn KS, Kim C, Shanmugam MK, Siveen KS, Arfuso F, Samy RP, Deivasigamani A, Lim LH, Wang L, Goh BC, Kumar AP, Hui KM, Sethi G. Nimbolide-induced oxidative stress abrogates STAT3 signaling cascade and inhibits tumor growth in transgenic adenocarcinoma of mouse prostate model. Antioxidants & Redox Signaling. PMID 26649526 DOI: 10.1089/Ars.2015.6418 |
0.41 |
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| 2015 |
Singh SS, Yap WN, Arfuso F, Kar S, Wang C, Cai W, Dharmarajan AM, Sethi G, Kumar AP. Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine? World Journal of Gastroenterology. 21: 12261-73. PMID 26604635 DOI: 10.3748/Wjg.V21.I43.12261 |
0.39 |
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| 2015 |
Perumal Samy R, Manikandan J, Pachiappan A, Ooi EE, Aw LT, Stiles BG, Franco OL, Kandasamy M, Mathi KM, Rane G, Siveen KS, Arunachalam C, Zayed ME, Alharbi SA, Kumar AP, et al. Gene Microarray Analyses of Daboia russelli russelli Daboiatoxin Treatment of THP-1 Human Macrophages Infected with Burkholderia pseudomallei. Current Molecular Medicine. PMID 26592245 DOI: 10.2174/1566524016666151123114123 |
0.33 |
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| 2015 |
Chai EZ, Shanmugam MK, Arfuso F, Dharmarajan A, Wang C, Kumar AP, Samy RP, Lim LH, Wang L, Goh BC, Ahn KS, Hui KM, Sethi G. Targeting transcription factor STAT3 for cancer prevention and therapy. Pharmacology & Therapeutics. PMID 26478441 DOI: 10.1016/J.Pharmthera.2015.10.004 |
0.463 |
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| 2015 |
Ong CW, Chong PY, McArt DG, Chan JY, Tan HT, Kumar AP, Chung MC, Clément MV, Soong R, Van Schaeybroeck S, Waugh DJ, Johnston PG, Dunne PD, Salto-Tellez M. The prognostic value of the stem-like group in colorectal cancer using a panel of immunohistochemistry markers. Oncotarget. 6: 12763-73. PMID 25906747 DOI: 10.18632/Oncotarget.3497 |
0.351 |
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| 2015 |
Dai X, Zhang J, Arfuso F, Chinnathambi A, Zayed ME, Alharbi SA, Kumar AP, Ahn KS, Sethi G. Targeting TNF-related apoptosis-inducing ligand (TRAIL) receptor by natural products as a potential therapeutic approach for cancer therapy. Experimental Biology and Medicine (Maywood, N.J.). 240: 760-73. PMID 25854879 DOI: 10.1177/1535370215579167 |
0.417 |
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| 2015 |
Manu KA, Shanmugam MK, Ramachandran L, Li F, Siveen KS, Chinnathambi A, Zayed ME, Alharbi SA, Arfuso F, Kumar AP, Ahn KS, Sethi G. Isorhamnetin augments the anti-tumor effect of capeciatbine through the negative regulation of NF-κB signaling cascade in gastric cancer. Cancer Letters. 363: 28-36. PMID 25827070 DOI: 10.1016/J.Canlet.2015.03.033 |
0.438 |
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| 2015 |
Li F, Shanmugam MK, Siveen KS, Wang F, Ong TH, Loo SY, Swamy MM, Mandal S, Kumar AP, Goh BC, Kundu T, Ahn KS, Wang LZ, Hui KM, Sethi G. Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers. Oncotarget. 6: 5147-63. PMID 25762616 DOI: 10.18632/Oncotarget.2881 |
0.375 |
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| 2015 |
Li F, Zhang J, Arfuso F, Chinnathambi A, Zayed ME, Alharbi SA, Kumar AP, Ahn KS, Sethi G. NF-κB in cancer therapy. Archives of Toxicology. 89: 711-31. PMID 25690730 DOI: 10.1007/S00204-015-1470-4 |
0.402 |
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| 2015 |
Shanmugam MK, Rane G, Kanchi MM, Arfuso F, Chinnathambi A, Zayed ME, Alharbi SA, Tan BK, Kumar AP, Sethi G. The multifaceted role of curcumin in cancer prevention and treatment. Molecules (Basel, Switzerland). 20: 2728-69. PMID 25665066 DOI: 10.3390/Molecules20022728 |
0.473 |
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| 2015 |
Dai X, Ahn KS, Kim C, Siveen KS, Ong TH, Shanmugam MK, Li F, Shi J, Kumar AP, Wang LZ, Goh BC, Magae J, Hui KM, Sethi G. Ascochlorin, an isoprenoid antibiotic inhibits growth and invasion of hepatocellular carcinoma by targeting STAT3 signaling cascade through the induction of PIAS3. Molecular Oncology. 9: 818-33. PMID 25624051 DOI: 10.1016/J.Molonc.2014.12.008 |
0.406 |
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| 2015 |
Shanmugam MK, Rajendran P, Li F, Kim C, Sikka S, Siveen KS, Kumar AP, Ahn KS, Sethi G. Abrogation of STAT3 signaling cascade by zerumbone inhibits proliferation and induces apoptosis in renal cell carcinoma xenograft mouse model Molecular Carcinogenesis. 54: 971-985. PMID 24797723 DOI: 10.1002/Mc.22166 |
0.422 |
|
| 2015 |
Cai W, Wang C, Goh JN, Loo SY, Yap CT, Kumar AP. DEAD-box RNA Helicases: the microRNA managers of breast cancer Rna & Disease. 2. DOI: 10.14800/Rd.846 |
0.334 |
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| 2015 |
Zhang J, Shanmugam MK, Deivasigamani A, Kumar AP, Hui KM, Sethi G. Abstract 677: Possible role of nimbolide in prevention and therapy of prostate cancer Cancer Research. 75: 677-677. DOI: 10.1158/1538-7445.Am2015-677 |
0.407 |
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| 2014 |
Mohan CD, Bharathkumar H, Bulusu KC, Pandey V, Rangappa S, Fuchs JE, Shanmugam MK, Dai X, Li F, Deivasigamani A, Hui KM, Kumar AP, Lobie PE, Bender A, Basappa, et al. Development of a novel azaspirane that targets the Janus kinase-signal transducer and activator of transcription (STAT) pathway in hepatocellular carcinoma in vitro and in vivo. The Journal of Biological Chemistry. 289: 34296-307. PMID 25320076 DOI: 10.1074/Jbc.M114.601104 |
0.447 |
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| 2014 |
Gee VM, Wong FS, Ramachandran L, Sethi G, Kumar AP, Yap CW. Identification of novel peroxisome proliferator-activated receptor-gamma (PPARγ) agonists using molecular modeling method. Journal of Computer-Aided Molecular Design. 28: 1143-51. PMID 25168706 DOI: 10.1007/S10822-014-9791-6 |
0.311 |
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| 2014 |
Datta A, Loo SY, Huang B, Wong L, Tan SS, Tan TZ, Lee SC, Thiery JP, Lim YC, Yong WP, Lam Y, Kumar AP, Yap CT. SPHK1 regulates proliferation and survival responses in triple-negative breast cancer. Oncotarget. 5: 5920-33. PMID 25153718 DOI: 10.18632/Oncotarget.1874 |
0.434 |
|
| 2014 |
Siveen KS, Nguyen AH, Lee JH, Li F, Singh SS, Kumar AP, Low G, Jha S, Tergaonkar V, Ahn KS, Sethi G. Negative regulation of signal transducer and activator of transcription-3 signalling cascade by lupeol inhibits growth and induces apoptosis in hepatocellular carcinoma cells. British Journal of Cancer. 111: 1327-37. PMID 25101566 DOI: 10.1038/Bjc.2014.422 |
0.375 |
|
| 2014 |
Shin EM, Hay HS, Lee MH, Goh JN, Tan TZ, Sen YP, Lim SW, Yousef EM, Ong HT, Thike AA, Kong X, Wu Z, Mendoz E, Sun W, Salto-Tellez M, ... ... Kumar AP, et al. DEAD-box helicase DP103 defines metastatic potential of human breast cancers. The Journal of Clinical Investigation. 124: 3807-24. PMID 25083991 DOI: 10.1172/Jci73451 |
0.431 |
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| 2014 |
Hambright HG, Batth IS, Xie J, Ghosh R, Kumar AP. Palmatine inhibits growth and invasion in prostate cancer cell: Potential role for rpS6/NFκB/FLIP. Molecular Carcinogenesis. PMID 25043857 DOI: 10.1002/mc.22192 |
0.304 |
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| 2014 |
Gong J, Muñoz AR, Chan D, Ghosh R, Kumar AP. STAT3 down regulates LC3 to inhibit autophagy and pancreatic cancer cell growth. Oncotarget. 5: 2529-41. PMID 24796733 DOI: 10.18632/ONCOTARGET.1810 |
0.345 |
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| 2014 |
Siveen KS, Ahn KS, Ong TH, Shanmugam MK, Li F, Yap WN, Kumar AP, Fong CW, Tergaonkar V, Hui KM, Sethi G. Y-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model. Oncotarget. 5: 1897-911. PMID 24722367 DOI: 10.18632/Oncotarget.1876 |
0.392 |
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| 2014 |
Sethi G, Chatterjee S, Rajendran P, Li F, Shanmugam MK, Wong KF, Kumar AP, Senapati P, Behera AK, Hui KM, Basha J, Natesh N, Luk JM, Kundu TK. Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo. Molecular Cancer. 13: 66. PMID 24655440 DOI: 10.1186/1476-4598-13-66 |
0.372 |
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| 2014 |
Siveen KS, Mustafa N, Li F, Kannaiyan R, Ahn KS, Kumar AP, Chng WJ, Sethi G. Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-κB regulated gene products in multiple myeloma xenograft mouse model. Oncotarget. 5: 634-48. PMID 24504138 DOI: 10.18632/Oncotarget.1596 |
0.393 |
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| 2014 |
Shanmugam MK, Dai X, Kumar AP, Tan BK, Sethi G, Bishayee A. Oleanolic acid and its synthetic derivatives for the prevention and therapy of cancer: preclinical and clinical evidence. Cancer Letters. 346: 206-16. PMID 24486850 DOI: 10.1016/J.Canlet.2014.01.016 |
0.415 |
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| 2014 |
Warner S, Balu SK, Kumar AP, Millward M, Dharmarajan A. Wnt antagonist, secreted frizzled-related protein 4 (sFRP4), increases chemotherapeutic response of glioma stem-like cells Oncology Research. 21: 93-102. PMID 24406045 DOI: 10.3727/096504013X13786659070154 |
0.402 |
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| 2014 |
Siveen KS, Sikka S, Surana R, Dai X, Zhang J, Kumar AP, Tan BK, Sethi G, Bishayee A. Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors. Biochimica Et Biophysica Acta. 1845: 136-54. PMID 24388873 DOI: 10.1016/J.Bbcan.2013.12.005 |
0.4 |
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| 2014 |
Surana R, Sikka S, Cai W, Shin EM, Warrier SR, Tan HJ, Arfuso F, Fox SA, Dharmarajan AM, Kumar AP. Secreted frizzled related proteins: Implications in cancers. Biochimica Et Biophysica Acta. 1845: 53-65. PMID 24316024 DOI: 10.1016/j.bbcan.2013.11.004 |
0.332 |
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| 2014 |
Manu KA, Shanmugam MK, Li F, Chen L, Siveen KS, Ahn KS, Kumar AP, Sethi G. Simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine by suppressing nuclear factor-kappa B-regulated gene products. Journal of Molecular Medicine (Berlin, Germany). 92: 267-76. PMID 24233024 DOI: 10.1007/S00109-013-1095-0 |
0.449 |
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| 2014 |
Kumar AP, Loo SY, Shin SW, Tan TZ, Eng CB, Singh R, Putti TC, Ong CW, Salto-Tellez M, Goh BC, Park JI, Thiery JP, Pervaiz S, Clement MV. Manganese superoxide dismutase is a promising target for enhancing chemosensitivity of basal-like breast carcinoma. Antioxidants & Redox Signaling. 20: 2326-46. PMID 23964924 DOI: 10.1089/Ars.2013.5295 |
0.375 |
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| 2014 |
Gong J, Kumar SA, Graham G, Kumar AP. FLIP: Molecular switch between apoptosis and necroptosis Molecular Carcinogenesis. 53: 675-685. PMID 23625539 DOI: 10.1002/mc.22027 |
0.314 |
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| 2014 |
Nachiyappan A, Shanmugam MK, Li F, Kumar AP, Sethi G. Abstract 3790: Artesunate inhibits multiple proinflammatory transcription factors leading to the suppression of growth and induction of apoptosis in prostate cancer cells Cancer Research. 74: 3790-3790. DOI: 10.1158/1538-7445.Am2014-3790 |
0.472 |
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| 2014 |
Bharathkumar H, Paricharak S, Dinesh KR, Siveen KS, Fuchs JE, Rangappa S, Mohan CD, Mohandas N, Kumar AP, Sethi G, Bender A, Basappa, Rangappa KS. Synthesis, biological evaluation and in silico and in vitro mode-of-action analysis of novel dihydropyrimidones targeting PPAR-γ Rsc Advances. 4: 45143-45146. DOI: 10.1039/C4Ra08713E |
0.352 |
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| 2014 |
Chua AWL, Hay HS, Rajendran P, Shanmugam MK, Li F, Bist P, Koay ESC, Lim LHK, Kumar AP, Sethi G. Corrigendum to “Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-κB activation in breast and pancreatic tumor cells” [Biochem. Pharmacol. 80 (2010) 1553–1562] Biochemical Pharmacology. 89: 557-558. DOI: 10.1016/J.Bcp.2014.04.013 |
0.344 |
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| 2014 |
Sikka S, Shanmugam MK, Kannaiyan R, Surana R, Shin EM, Kumar AP, Sethi G, Ahn KS. Suppression of essential pro-inflammatory signaling pathways by natural agents for the therapy of multiple myeloma Phytochemistry Reviews. 13: 79-106. DOI: 10.1007/S11101-013-9287-3 |
0.368 |
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| 2013 |
Woo CC, Hsu A, Kumar AP, Sethi G, Tan KH. Thymoquinone inhibits tumor growth and induces apoptosis in a breast cancer xenograft mouse model: the role of p38 MAPK and ROS. Plos One. 8: e75356. PMID 24098377 DOI: 10.1371/Journal.Pone.0075356 |
0.437 |
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| 2013 |
Shrimali D, Shanmugam MK, Kumar AP, Zhang J, Tan BK, Ahn KS, Sethi G. Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer. Cancer Letters. 341: 139-49. PMID 23962559 DOI: 10.1016/J.Canlet.2013.08.023 |
0.434 |
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| 2013 |
Subramaniam A, Shanmugam MK, Ong TH, Li F, Perumal E, Chen L, Vali S, Abbasi T, Kapoor S, Ahn KS, Kumar AP, Hui KM, Sethi G. Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3. British Journal of Pharmacology. 170: 807-21. PMID 23848338 DOI: 10.1111/Bph.12302 |
0.337 |
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| 2013 |
Li F, Shanmugam MK, Chen L, Chatterjee S, Basha J, Kumar AP, Kundu TK, Sethi G. Garcinol, a polyisoprenylated benzophenone modulates multiple proinflammatory signaling cascades leading to the suppression of growth and survival of head and neck carcinoma. Cancer Prevention Research (Philadelphia, Pa.). 6: 843-54. PMID 23803415 DOI: 10.1158/1940-6207.Capr-13-0070 |
0.422 |
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| 2013 |
Subramaniam A, Loo SY, Rajendran P, Manu KA, Perumal E, Li F, Shanmugam MK, Siveen KS, Park JI, Ahn KS, Hui KM, Kumar AP, Sethi G. An anthraquinone derivative, emodin sensitizes hepatocellular carcinoma cells to TRAIL induced apoptosis through the induction of death receptors and downregulation of cell survival proteins. Apoptosis : An International Journal On Programmed Cell Death. 18: 1175-87. PMID 23700228 DOI: 10.1007/S10495-013-0851-5 |
0.361 |
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| 2013 |
Zhu Y, Casey PJ, Kumar AP, Pervaiz S. Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases. Cell Death & Disease. 4: e568. PMID 23559002 DOI: 10.1038/Cddis.2013.103 |
0.419 |
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| 2013 |
Shanmugam MK, Dai X, Kumar AP, Tan BK, Sethi G, Bishayee A. Ursolic acid in cancer prevention and treatment: molecular targets, pharmacokinetics and clinical studies. Biochemical Pharmacology. 85: 1579-87. PMID 23499879 DOI: 10.1016/J.Bcp.2013.03.006 |
0.344 |
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| 2013 |
Manu KA, Shanmugam MK, Ong TH, Subramaniam A, Siveen KS, Perumal E, Samy RP, Bist P, Lim LH, Kumar AP, Hui KM, Sethi G. Emodin suppresses migration and invasion through the modulation of CXCR4 expression in an orthotopic model of human hepatocellular carcinoma. Plos One. 8: e57015. PMID 23472074 DOI: 10.1371/Journal.Pone.0057015 |
0.362 |
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| 2013 |
Subramaniam A, Shanmugam MK, Perumal E, Li F, Nachiyappan A, Dai X, Swamy SN, Ahn KS, Kumar AP, Tan BK, Hui KM, Sethi G. Potential role of signal transducer and activator of transcription (STAT)3 signaling pathway in inflammation, survival, proliferation and invasion of hepatocellular carcinoma. Biochimica Et Biophysica Acta. 1835: 46-60. PMID 23103770 DOI: 10.1016/J.Bbcan.2012.10.002 |
0.402 |
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| 2013 |
Shanmugam MK, Kumar AP, Tan BKH, Sethi G. Role of NF-κB in tumorigenesis Forum On Immunopathological Diseases and Therapeutics. 4: 181-196. DOI: 10.1615/Forumimmundisther.2013008382 |
0.419 |
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| 2013 |
Shanmugam MK, Chatterjee S, Peramaiyan R, Li F, Senapati P, Wong KF, Kumar AP, Luk JM, Hui KM, Sethi G, Kundu TK. Abstract 4711: Targeted inhibition of STAT3 dimerization by garcinol suppresses the growth of human hepatocellular carcinomain vitroandin vivo. Immunology. 73: 4711-4711. DOI: 10.1158/1538-7445.Am2013-4711 |
0.322 |
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| 2013 |
Ramachandran L, Manu KA, Shanmugam MK, Li F, Siveen KS, Vali S, Kapoor S, Abbasi T, Surana R, Smoot DT, Ashktorab H, Tan P, Ahn KS, Yap CW, Kumar AP, et al. Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer (Journal of Biological Chemistry (2012) 287, (38028-38040)) Journal of Biological Chemistry. 288: 18777. DOI: 10.1074/Jbc.A112.388702 |
0.421 |
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| 2013 |
Zhu Y, Casey PJ, Kumar AP, Pervaiz S. Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: Evidence for non-canonical activation of RhoA and Rac1 GTPases Cell Death and Disease. 4. DOI: 10.1038/cddis.2013.103 |
0.309 |
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| 2012 |
Sikka S, Chen L, Sethi G, Kumar AP. Targeting PPARγ Signaling Cascade for the Prevention and Treatment of Prostate Cancer. Ppar Research. 2012: 968040. PMID 23213321 DOI: 10.1155/2012/968040 |
0.456 |
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| 2012 |
Ramachandran L, Manu KA, Shanmugam MK, Li F, Siveen KS, Vali S, Kapoor S, Abbasi T, Surana R, Smoot DT, Ashktorab H, Tan P, Ahn KS, Yap CW, Kumar AP, et al. Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer. The Journal of Biological Chemistry. 287: 38028-40. PMID 22992727 DOI: 10.1074/Jbc.M112.388702 |
0.44 |
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| 2012 |
Zhuo J, Tan EH, Yan B, Tochhawng L, Jayapal M, Koh S, Tay HK, Maciver SK, Hooi SC, Salto-Tellez M, Kumar AP, Goh YC, Lim YC, Yap CT. Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascade. Plos One. 7: e43594. PMID 22927998 DOI: 10.1371/Journal.Pone.0043594 |
0.424 |
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| 2012 |
Prasannan R, Kalesh KA, Shanmugam MK, Nachiyappan A, Ramachandran L, Nguyen AH, Kumar AP, Lakshmanan M, Ahn KS, Sethi G. Key cell signaling pathways modulated by zerumbone: role in the prevention and treatment of cancer. Biochemical Pharmacology. 84: 1268-76. PMID 22842489 DOI: 10.1016/J.Bcp.2012.07.015 |
0.391 |
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| 2012 |
Shanmugam MK, Ong TH, Kumar AP, Lun CK, Ho PC, Wong PT, Hui KM, Sethi G. Ursolic acid inhibits the initiation, progression of prostate cancer and prolongs the survival of TRAMP mice by modulating pro-inflammatory pathways. Plos One. 7: e32476. PMID 22427843 DOI: 10.1371/Journal.Pone.0032476 |
0.35 |
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| 2012 |
Shanmugam MK, Nguyen AH, Kumar AP, Tan BK, Sethi G. Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: potential role in prevention and therapy of cancer. Cancer Letters. 320: 158-70. PMID 22406826 DOI: 10.1016/J.Canlet.2012.02.037 |
0.461 |
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| 2012 |
Rajendran P, Li F, Shanmugam MK, Kannaiyan R, Goh JN, Wong KF, Wang W, Khin E, Tergaonkar V, Kumar AP, Luk JM, Sethi G. Celastrol suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade in vitro and in vivo. Cancer Prevention Research (Philadelphia, Pa.). 5: 631-43. PMID 22369852 DOI: 10.1158/1940-6207.Capr-11-0420 |
0.416 |
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| 2012 |
Loo SY, Chang MK, Chua CS, Kumar AP, Pervaiz S, Clement MV. NHE-1: a promising target for novel anti-cancer therapeutics. Current Pharmaceutical Design. 18: 1372-82. PMID 22360552 DOI: 10.2174/138161212799504885 |
0.388 |
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| 2012 |
Manu KA, Shanmugam MK, Ramachandran L, Li F, Fong CW, Kumar AP, Tan P, Sethi G. First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 2220-9. PMID 22351692 DOI: 10.1158/1078-0432.Ccr-11-2470 |
0.445 |
|
| 2012 |
Woo CC, Kumar AP, Sethi G, Tan KH. Thymoquinone: potential cure for inflammatory disorders and cancer. Biochemical Pharmacology. 83: 443-51. PMID 22005518 DOI: 10.1016/J.Bcp.2011.09.029 |
0.392 |
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| 2012 |
Sethi G, Shanmugam MK, Ramachandran L, Kumar AP, Tergaonkar V. Multifaceted link between cancer and inflammation. Bioscience Reports. 32: 1-15. PMID 21981137 DOI: 10.1042/Bsr20100136 |
0.423 |
|
| 2012 |
Rajendran P, Li F, Shanmugam MK, Vali S, Abbasi T, Kapoor S, Ahn KS, Kumar AP, Sethi G. Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1. Journal of Cellular Physiology. 227: 2184-95. PMID 21792937 DOI: 10.1002/Jcp.22954 |
0.427 |
|
| 2012 |
Ramachandran L, Aryan MK, Luxi C, Feng L, Rajendran P, Yap CW, Kumar AP, Sethi G. Abstract 1978: Isorhamnetin modulates PPARδ activation pathway leading to the suppression of proliferation, invasion and induction of apoptosis in gastric cancer Cancer Research. 72: 1978-1978. DOI: 10.1158/1538-7445.Am2012-1978 |
0.438 |
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| 2011 |
Manu KA, Shanmugam MK, Rajendran P, Li F, Ramachandran L, Hay HS, Kannaiyan R, Swamy SN, Vali S, Kapoor S, Ramesh B, Bist P, Koay ES, Lim LH, Ahn KS, ... Kumar AP, et al. Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4. Molecular Cancer. 10: 107. PMID 21880153 DOI: 10.1186/1476-4598-10-107 |
0.485 |
|
| 2011 |
Kannaiyan R, Manu KA, Chen L, Li F, Rajendran P, Subramaniam A, Lam P, Kumar AP, Sethi G. Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways. Apoptosis : An International Journal On Programmed Cell Death. 16: 1028-41. PMID 21786165 DOI: 10.1007/S10495-011-0629-6 |
0.478 |
|
| 2011 |
Venkatachalam G, Kumar AP, Sakharkar KR, Thangavel S, Clement MV, Sakharkar MK. PPARγ disease gene network and identification of therapeutic targets for prostate cancer. Journal of Drug Targeting. 19: 781-96. PMID 21780947 DOI: 10.3109/1061186X.2011.568062 |
0.365 |
|
| 2011 |
Woo CC, Loo SY, Gee V, Yap CW, Sethi G, Kumar AP, Tan KH. Anticancer activity of thymoquinone in breast cancer cells: possible involvement of PPAR-γ pathway. Biochemical Pharmacology. 82: 464-75. PMID 21679698 DOI: 10.1016/J.Bcp.2011.05.030 |
0.47 |
|
| 2011 |
Kannaiyan R, Hay HS, Rajendran P, Li F, Shanmugam MK, Vali S, Abbasi T, Kapoor S, Sharma A, Kumar AP, Chng WJ, Sethi G. Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells. British Journal of Pharmacology. 164: 1506-21. PMID 21506956 DOI: 10.1111/J.1476-5381.2011.01449.X |
0.417 |
|
| 2011 |
Shanmugam MK, Manu KA, Ong TH, Ramachandran L, Surana R, Bist P, Lim LH, Kumar AP, Hui KM, Sethi G. Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model. International Journal of Cancer. 129: 1552-63. PMID 21480220 DOI: 10.1002/Ijc.26120 |
0.397 |
|
| 2011 |
Shanmugam MK, Rajendran P, Li F, Nema T, Vali S, Abbasi T, Kapoor S, Sharma A, Kumar AP, Ho PC, Hui KM, Sethi G. Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice. Journal of Molecular Medicine (Berlin, Germany). 89: 713-27. PMID 21465181 DOI: 10.1007/S00109-011-0746-2 |
0.456 |
|
| 2011 |
Rajendran P, Li F, Manu KA, Shanmugam MK, Loo SY, Kumar AP, Sethi G. γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent. British Journal of Pharmacology. 163: 283-98. PMID 21198544 DOI: 10.1111/J.1476-5381.2010.01187.X |
0.443 |
|
| 2010 |
Chua AW, Hay HS, Rajendran P, Shanmugam MK, Li F, Bist P, Koay ES, Lim LH, Kumar AP, Sethi G. Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-κB activation in breast and pancreatic tumor cells. Biochemical Pharmacology. 80: 1553-62. PMID 20699088 DOI: 10.1016/J.Bcp.2010.07.045 |
0.467 |
|
| 2010 |
Tan SML, Li F, Rajendran P, Kumar AP, Hui KM, Sethi G. Identification of β-escin as a novel inhibitor of signal transducer and activator of transcription 3/janus-activated kinase 2 signaling pathway that suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells Journal of Pharmacology and Experimental Therapeutics. 334: 285-293. PMID 20378717 DOI: 10.1124/Jpet.110.165498 |
0.397 |
|
| 2009 |
Venkatachalam G, Kumar AP, Yue LS, Pervaiz S, Clement MV, Sakharkar MK. Computational identification and experimental validation of PPRE motifs in NHE1 and MnSOD genes of human. Bmc Genomics. 10: S5. PMID 19958503 DOI: 10.1186/1471-2164-10-S3-S5 |
0.396 |
|
| 2009 |
Kumar AP, Quake AL, Chang MK, Zhou T, Lim KS, Singh R, Hewitt RE, Salto-Tellez M, Pervaiz S, Clément MV. Repression of NHE1 expression by PPARgamma activation is a potential new approach for specific inhibition of the growth of tumor cells in vitro and in vivo. Cancer Research. 69: 8636-44. PMID 19887620 DOI: 10.1158/0008-5472.Can-09-0219 |
0.485 |
|
| 2009 |
Hou HW, Li QS, Lee GYH, Kumar AP, Ong CN, Lim CT. Deformability study of breast cancer cells using microfluidics. Biomedical Microdevices. 11: 557-564. PMID 19082733 DOI: 10.1007/S10544-008-9262-8 |
0.362 |
|
| 2006 |
Reynolds WF, Kumar AP, Piedrafita FJ. The human myeloperoxidase gene is regulated by LXR and PPARalpha ligands. Biochemical and Biophysical Research Communications. 349: 846-54. PMID 16956579 DOI: 10.1016/J.Bbrc.2006.08.119 |
0.303 |
|
| 2006 |
Garcia GE, Nicole A, Bhaskaran S, Gupta A, Kyprianou N, Kumar AP. Akt-and CREB-mediated prostate cancer cell proliferation inhibition by Nexrutine, a Phellodendron amurense extract. Neoplasia (New York, N.Y.). 8: 523-33. PMID 16820098 DOI: 10.1593/Neo.05745 |
0.305 |
|
| 2005 |
Kumar AP, Ryan C, Cordy V, Reynolds WF. Inducible nitric oxide synthase expression is inhibited by myeloperoxidase. Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. 13: 42-53. PMID 15893945 DOI: 10.1016/J.Niox.2005.04.002 |
0.302 |
|
| 2005 |
Kumar AP, Reynolds WF. Statins downregulate myeloperoxidase gene expression in macrophages. Biochemical and Biophysical Research Communications. 331: 442-51. PMID 15850779 DOI: 10.1016/J.Bbrc.2005.03.204 |
0.32 |
|
| 2004 |
Kumar AP, Piedrafita FJ, Reynolds WF. Peroxisome proliferator-activated receptor gamma ligands regulate myeloperoxidase expression in macrophages by an estrogen-dependent mechanism involving the -463GA promoter polymorphism. The Journal of Biological Chemistry. 279: 8300-15. PMID 14668325 DOI: 10.1074/Jbc.M311625200 |
0.338 |
|
| 2000 |
Wang A, Schneider-Broussard R, Kumar AP, MacLeod MC, Johnson DG. Regulation of BRCA1 expression by the Rb-E2F pathway. The Journal of Biological Chemistry. 275: 4532-6. PMID 10660629 DOI: 10.1074/jbc.275.6.4532 |
0.31 |
|
| 1995 |
Schurr MJ, Vickrey JF, Kumar AP, Campbell AL, Cunin R, Benjamin RC, Shanley MS, O'Donovan GA. Aspartate transcarbamoylase genes of Pseudomonas putida: requirement for an inactive dihydroorotase for assembly into the dodecameric holoenzyme. Journal of Bacteriology. 177: 1751-9. PMID 7896697 |
0.595 |
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