Youhai H. Chen - Publications

Affiliations: 
Cell and Molecular Biology University of Pennsylvania, Philadelphia, PA, United States 
Area:
Molecular Biology, Cell Biology, Immunology

134 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Lou Y, Jiang S, Song M, Wang H, Han M, Tian X, Zhao Y, Gao J, Song Y, Ma S, Zhao P, Zheng Q, Niu Z, Zhang W, Chang T, ... Chen YH, et al. Epithelial TIPE1 Protein Guards against Colitis by Inhibiting TNF-α-Mediated Inflammation. Journal of Immunology (Baltimore, Md. : 1950). PMID 37459052 DOI: 10.4049/jimmunol.2300291  0.312
2021 Li M, Bou-Dargham MJ, Yu J, Etwebi Z, Sun H, Chen YH. TIPE polarity proteins are required for mucosal deployment of T lymphocytes and mucosal defense against bacterial infection. Molecular Biomedicine (Online). 2: 41. PMID 34939151 DOI: 10.1186/s43556-021-00059-8  0.339
2020 Yang L, Liu S, Liu J, Zhang Z, Wan X, Huang B, Chen Y, Zhang Y. COVID-19: immunopathogenesis and Immunotherapeutics. Signal Transduction and Targeted Therapy. 5: 128. PMID 32712629 DOI: 10.1038/S41392-020-00243-2  0.328
2020 Li X, Luo G, Li T, Sun H, Wang W, Eiler E, Goldsmith JR, Chen YH. The c-Rel-c-Myc axis controls metabolism and proliferation of human T leukemia cells. Molecular Immunology. 125: 115-122. PMID 32659596 DOI: 10.1016/J.Molimm.2020.06.029  0.35
2020 Chen X, Li X, Liu Y, Zhang Z, Zhang X, Huang J, Li H, Li F, Zhang L, Li L, Wu X, Ma W, Sun Z, Yu H, Zhou Z, ... ... Chen YH, et al. A Phase I clinical trial of chimeric antigen receptor-modified T cells in patients with relapsed and refractory lymphoma. Immunotherapy. PMID 32580597 DOI: 10.2217/Imt-2020-0022  0.348
2020 Goldsmith JR, Spitofsky N, Zamani A, Hood R, Boggs A, Li X, Li M, Reiner E, Ayyaz A, Etwebi Z, Lu L, Rivera Guzman J, Bou-Dargham MJ, Cathoupolis T, Hakonarson H, ... ... Chen YH, et al. TNFAIP8 controls murine intestinal stem cell homeostasis and regeneration by regulating microbiome-induced Akt signaling. Nature Communications. 11: 2591. PMID 32444641 DOI: 10.1038/S41467-020-16379-2  0.338
2020 Wang Y, Zhang H, Wang Z, Wei Y, Wang M, Liu M, Wang X, Jiang Y, Shi G, Zhao D, Yang Z, Ren Z, Li J, Zhang Z, Wang Z, ... ... Chen YH, et al. Blocking the death checkpoint protein TRAIL improves cardiac function after myocardial infarction in monkeys, pigs, and rats. Science Translational Medicine. 12. PMID 32321866 DOI: 10.1126/Scitranslmed.Aaw3172  0.346
2020 Sun H, Lin M, Zamani A, Goldsmith JR, Boggs AE, Li M, Lee CN, Chen X, Li X, Li T, Dorrity BL, Li N, Lou Y, Shi S, Wang W, ... Chen YH, et al. The TIPE Molecular Pilot That Directs Lymphocyte Migration in Health and Inflammation. Scientific Reports. 10: 6617. PMID 32313148 DOI: 10.1038/S41598-020-63629-W  0.436
2020 Berry CT, Liu X, Myles A, Nandi S, Chen YH, Hershberg U, Brodsky IE, Cancro MP, Lengner CJ, May MJ, Freedman BD. BCR-Induced Ca Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells. Cell Reports. 31: 107474. PMID 32294437 DOI: 10.1016/J.Celrep.2020.03.038  0.391
2020 Lou Y, Han M, Song Y, Zhong J, Zhang W, Chen YH, Wang H. The SCF E3 Ubiquitin Ligase Regulates Immune Receptor Signaling by Targeting the Negative Regulatory Protein TIPE2. Journal of Immunology (Baltimore, Md. : 1950). PMID 32188758 DOI: 10.4049/Jimmunol.1901142  0.353
2019 Chen Q, Yan D, Zhang Q, Zhang G, Xia M, Li J, Zhan W, Shen E, Li Z, Lin L, Chen YH, Wan X. Treatment of acetaminophen-induced liver failure by blocking the death checkpoint protein TRAIL. Biochimica Et Biophysica Acta. Molecular Basis of Disease. 165583. PMID 31676378 DOI: 10.1016/J.Bbadis.2019.165583  0.339
2019 Yan D, Wang J, Sun H, Zamani A, Zhang H, Chen W, Tang A, Ruan Q, Yang X, Chen YH, Wan X. TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis. The Journal of Experimental Medicine. PMID 31662347 DOI: 10.1084/Jem.20182005  0.414
2019 Kumari R, Palaniyandi S, Strattan E, Huang T, Kohler K, Jabbour N, Dalland J, Du J, Kesler MV, Chen YH, Hildebrandt GC. TNFAIP8 deficiency exacerbates acute graft versus host disease in a murine model of allogeneic hematopoietic cell transplantation. Transplantation. PMID 31634333 DOI: 10.1097/Tp.0000000000003013  0.408
2019 Yan D, Adeshakin AO, Xu M, Afolabi LO, Zhang G, Chen YH, Wan X. Lipid Metabolic Pathways Confer the Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Tumor. Frontiers in Immunology. 10: 1399. PMID 31275326 DOI: 10.3389/Fimmu.2019.01399  0.309
2019 Chen Q, Wang P, Zhang Q, Xia M, Zhang G, Li J, Shen E, Chen YH, Wan X. Preclinical studies of a death receptor 5 fusion protein that ameliorates acute liver failure. Journal of Molecular Medicine (Berlin, Germany). PMID 31230087 DOI: 10.1007/S00109-019-01813-W  0.381
2019 DeLaney AA, Berry CT, Christian DA, Hart A, Bjanes E, Wynosky-Dolfi MA, Li X, Tummers B, Udalova IA, Chen YH, Hershberg U, Freedman BD, Hunter CA, Brodsky IE. Caspase-8 promotes c-Rel-dependent inflammatory cytokine expression and resistance against . Proceedings of the National Academy of Sciences of the United States of America. PMID 31147458 DOI: 10.1073/Pnas.1820529116  0.458
2018 Liu Y, Chen X, Wang D, Li H, Huang J, Zhang Z, Qiao Y, Zhang H, Zeng Y, Tang C, Yang S, Wan X, Chen YH, Zhang Y. Hemofiltration Successfully Eliminates Severe Cytokine Release Syndrome Following CD19 CAR-T-Cell Therapy. Journal of Immunotherapy (Hagerstown, Md. : 1997). PMID 30198955 DOI: 10.1097/Cji.0000000000000243  0.379
2018 Li T, Wang W, Gong S, Sun H, Zhang H, Yang AG, Chen YH, Li X. Genome-wide analysis reveals TNFAIP8L2 as an immune checkpoint regulator of inflammation and metabolism. Molecular Immunology. 99: 154-162. PMID 29787979 DOI: 10.1016/J.Molimm.2018.05.007  0.333
2018 Fan T, Zhong F, Liu R, Chen YH, Wang T, Ruan Q. siRNA-mediated c-Rel knockdown ameliorates collagen-induced arthritis in mice. International Immunopharmacology. 56: 9-17. PMID 29324391 DOI: 10.1016/J.Intimp.2018.01.010  0.409
2018 Goldsmith JR, Boggs A, Cathopoulis T, Spitofsky N, Sun H, Chen Y. 826 - TNFAIP8 Deficiency Protects Against Intestinal Injury through Enhanced Epithelial Cell Resistance to Apoptosis via Altered Stemness Gastroenterology. 154: S-171. DOI: 10.1016/S0016-5085(18)30984-3  0.328
2017 Fayngerts SA, Wang Z, Zamani A, Sun H, Boggs AE, Porturas TP, Xie W, Lin M, Cathopoulis T, Goldsmith JR, Vourekas A, Chen YH. Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2. Nature Immunology. PMID 29058702 DOI: 10.1038/Ni.3866  0.745
2017 Ahmed A, Wan X, Mitxitorena I, Lindsay AJ, Paolo Pandolfi P, McCaffrey MW, Keeshan K, Chen YH, Carmody RJ. Regulation of NF-κB by PML and PML-RARα. Scientific Reports. 7: 44539. PMID 28317833 DOI: 10.1038/Srep44539  0.333
2017 Goldsmith JR, Chen YH. Regulation of inflammation and tumorigenesis by the TIPE family of phospholipid transfer proteins. Cellular & Molecular Immunology. PMID 28287114 DOI: 10.1038/Cmi.2017.4  0.387
2017 Bi J, Cui L, Yu G, Yang X, Chen Y, Wan X. NK Cells Alleviate Lung Inflammation by Negatively Regulating Group 2 Innate Lymphoid Cells. Journal of Immunology (Baltimore, Md. : 1950). PMID 28275135 DOI: 10.4049/Jimmunol.1601830  0.42
2017 Zhang H, Bi J, Yi H, Fan T, Ruan Q, Cai L, Chen YH, Wan X. Silencing c-Rel in macrophages dampens Th1 and Th17 immune responses and alleviates experimental autoimmune encephalomyelitis in mice. Immunology and Cell Biology. PMID 28202908 DOI: 10.1038/Icb.2017.11  0.405
2017 Liu R, Fan T, Geng W, Chen YH, Ruan Q, Zhang C. Negative Immune Regulator TIPE2 Promotes M2 Macrophage Differentiation through the Activation of PI3K-AKT Signaling Pathway. Plos One. 12: e0170666. PMID 28122045 DOI: 10.1371/Journal.Pone.0170666  0.365
2016 Hao C, Zhang N, Geng M, Ren Q, Li Y, Wang Y, Chen YH, Liu S. Clinical Significance of TIPE2 Protein Upregulation in Non-Hodgkin's Lymphoma. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 64: 556-64. PMID 27578327 DOI: 10.1369/0022155416662262  0.366
2016 Wang T, Shi W, Fan T, Wan X, Chen YH, Ruan Q. c-Rel is Required for the Induction of pTregs in the Eye but Not in the Gut Mucosa. Immunological Investigations. 1-11. PMID 27224262 DOI: 10.3109/08820139.2016.1172639  0.446
2016 Fan T, Wang S, Yu L, Yi H, Liu R, Geng W, Wan X, Ma Y, Cai L, Chen YH, Ruan Q. Treating psoriasis by targeting its susceptibility gene Rel. Clinical Immunology (Orlando, Fla.). PMID 26993753 DOI: 10.1016/J.Clim.2016.03.009  0.361
2016 Wang L, Zhao M, Guo C, Wang G, Zhu F, Wang J, Wang X, Wang Q, Zhao W, Shi Y, Chen YH, Zhang L. PDCD4 Deficiency Aggravated Colitis and Colitis-associated Colorectal Cancer Via Promoting IL-6/STAT3 Pathway in Mice. Inflammatory Bowel Diseases. PMID 26891257 DOI: 10.1097/Mib.0000000000000729  0.365
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... Chen YH, ... Chen YG, ... Chen Y, ... Chen Y, ... Chen Y, ... Chen YJ, ... Chen YQ, ... Chen Y, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356  0.425
2016 Wang L, Jiang Y, Song X, Guo C, Zhu F, Wang X, Wang Q, Shi Y, Wang J, Gao F, Zhao W, Chen YH, Zhang L. Pdcd4 deficiency enhances macrophage lipoautophagy and attenuates foam cell formation and atherosclerosis in mice. Cell Death & Disease. 7: e2055. PMID 26775706 DOI: 10.1038/Cddis.2015.416  0.429
2015 Jiang Y, Gao Q, Wang L, Guo C, Zhu F, Wang B, Wang Q, Gao F, Chen Y, Zhang L. Deficiency of programmed cell death 4 results in increased IL-10 expression by macrophages and thereby attenuates atherosclerosis in hyperlipidemic mice. Cellular & Molecular Immunology. PMID 26166769 DOI: 10.1038/Cmi.2015.47  0.395
2015 Sun H, Lou Y, Porturas T, Morrissey S, Luo G, Qi J, Ruan Q, Shi S, Chen YH. Exacerbated experimental colitis in TNFAIP8-deficient mice. Journal of Immunology (Baltimore, Md. : 1950). 194: 5736-42. PMID 25948814 DOI: 10.4049/Jimmunol.1401986  0.779
2015 Porturas TP, Sun H, Buchlis G, Lou Y, Liang X, Cathopoulis T, Fayngerts S, Johnson DS, Wang Z, Chen YH. Crucial Roles of TNFAIP8 Protein in Regulating Apoptosis and Listeria Infection. Journal of Immunology (Baltimore, Md. : 1950). 194: 5743-50. PMID 25948813 DOI: 10.4049/Jimmunol.1401987  0.765
2015 Zhang G, Zhao L, Wang Y, Shao J, Cui J, Lou Y, Geng M, Zhang N, Chen YH, Liu S. TIPE2 protein prevents injury-induced restenosis in mice. Biochimica Et Biophysica Acta. 1852: 1574-84. PMID 25912734 DOI: 10.1016/J.Bbadis.2015.04.018  0.404
2015 Zhang W, Zhang J, Zhao L, Shao J, Cui J, Guo C, Zhu F, Chen YH, Liu S. TIPE2 protein negatively regulates HBV-specific CD8⁺ T lymphocyte functions in humans. Molecular Immunology. 64: 204-9. PMID 25499447 DOI: 10.1016/J.Molimm.2014.11.019  0.41
2015 Zhang Z, Liang X, Gao L, Ma H, Liu X, Pan Y, Yan W, Shan H, Wang Z, Chen YH, Ma C. TIPE1 induces apoptosis by negatively regulating Rac1 activation in hepatocellular carcinoma cells Oncogene. 34: 2566-2574. PMID 25043299 DOI: 10.1038/Onc.2014.208  0.372
2014 Lou Y, Sun H, Morrissey S, Porturas T, Liu S, Hua X, Chen YH. Critical roles of TIPE2 protein in murine experimental colitis. Journal of Immunology (Baltimore, Md. : 1950). 193: 1064-70. PMID 24973456 DOI: 10.4049/Jimmunol.1400415  0.784
2014 Ruan Q, Wang P, Wang T, Qi J, Wei M, Wang S, Fan T, Johnson D, Wan X, Shi W, Sun H, Chen YH. MicroRNA-21 regulates T-cell apoptosis by directly targeting the tumor suppressor gene Tipe2. Cell Death & Disease. 5: e1095. PMID 24577093 DOI: 10.1038/Cddis.2014.47  0.565
2013 Lou Y, Liu S, Zhang C, Zhang G, Li J, Ni M, An G, Dong M, Liu X, Zhu F, Zhang W, Gao F, Chen YH, Zhang Y. Enhanced atherosclerosis in TIPE2-deficient mice is associated with increased macrophage responses to oxidized low-density lipoprotein. Journal of Immunology (Baltimore, Md. : 1950). 191: 4849-57. PMID 24081993 DOI: 10.4049/Jimmunol.1300053  0.395
2013 Song X, Zhang X, Wang X, Zhu F, Guo C, Wang Q, Shi Y, Wang J, Chen Y, Zhang L. Tumor suppressor gene PDCD4 negatively regulates autophagy by inhibiting the expression of autophagy-related gene ATG5. Autophagy. 9: 743-55. PMID 23486359 DOI: 10.4161/Auto.24069  0.344
2013 Zhang G, Zhang W, Lou Y, Xi W, Cui J, Geng M, Zhu F, Chen YH, Liu S. TIPE2 deficiency accelerates neointima formation by downregulating smooth muscle cell differentiation. Cell Cycle (Georgetown, Tex.). 12: 501-10. PMID 23324338 DOI: 10.4161/Cc.23325  0.378
2012 Wang Z, Fayngerts S, Wang P, Sun H, Johnson DS, Ruan Q, Guo W, Chen YH. TIPE2 protein serves as a negative regulator of phagocytosis and oxidative burst during infection. Proceedings of the National Academy of Sciences of the United States of America. 109: 15413-8. PMID 22949657 DOI: 10.1073/Pnas.1204525109  0.543
2012 Schlenner SM, Weigmann B, Ruan Q, Chen Y, von Boehmer H. Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut. The Journal of Experimental Medicine. 209: 1529-35. PMID 22908322 DOI: 10.1084/Jem.20112646  0.419
2012 Sun H, Zhuang G, Chai L, Wang Z, Johnson D, Ma Y, Chen YH. TIPE2 controls innate immunity to RNA by targeting the phosphatidylinositol 3-kinase-Rac pathway. Journal of Immunology (Baltimore, Md. : 1950). 189: 2768-73. PMID 22904303 DOI: 10.4049/Jimmunol.1103477  0.534
2012 Yan Q, Carmody RJ, Qu Z, Ruan Q, Jager J, Mullican SE, Lazar MA, Chen YH. Nuclear factor-κB binding motifs specify Toll-like receptor-induced gene repression through an inducible repressosome. Proceedings of the National Academy of Sciences of the United States of America. 109: 14140-5. PMID 22891325 DOI: 10.1073/Pnas.1119842109  0.321
2012 Zhang Y, Wei X, Liu L, Liu S, Wang Z, Zhang B, Fan B, Yang F, Huang S, Jiang F, Chen YH, Yi F. TIPE2, a novel regulator of immunity, protects against experimental stroke. The Journal of Biological Chemistry. 287: 32546-55. PMID 22859306 DOI: 10.1074/Jbc.M112.348755  0.342
2012 Johnson DS, Chen YH. Ras family of small GTPases in immunity and inflammation. Current Opinion in Pharmacology. 12: 458-63. PMID 22401931 DOI: 10.1016/J.Coph.2012.02.003  0.489
2012 Gus-Brautbar Y, Johnson D, Zhang L, Sun H, Wang P, Zhang S, Zhang L, Chen YH. The anti-inflammatory TIPE2 is an inhibitor of the oncogenic Ras. Molecular Cell. 45: 610-8. PMID 22326055 DOI: 10.1016/J.Molcel.2012.01.006  0.539
2012 Ruan Q, Chen YH. Nuclear factor-κB in immunity and inflammation: the Treg and Th17 connection. Advances in Experimental Medicine and Biology. 946: 207-21. PMID 21948370 DOI: 10.1007/978-1-4614-0106-3_12  0.469
2011 Ruan Q, Kameswaran V, Zhang Y, Zheng S, Sun J, Wang J, DeVirgiliis J, Liou HC, Beg AA, Chen YH. The Th17 immune response is controlled by the Rel-RORγ-RORγ T transcriptional axis. The Journal of Experimental Medicine. 208: 2321-33. PMID 22006976 DOI: 10.1084/Jem.20110462  0.404
2011 Ruan Q, Wang T, Kameswaran V, Wei Q, Johnson DS, Matschinsky F, Shi W, Chen YH. The microRNA-21-PDCD4 axis prevents type 1 diabetes by blocking pancreatic beta cell death. Proceedings of the National Academy of Sciences of the United States of America. 108: 12030-5. PMID 21730150 DOI: 10.1073/Pnas.1101450108  0.575
2011 Xi W, Hu Y, Liu Y, Zhang J, Wang L, Lou Y, Qu Z, Cui J, Zhang G, Liang X, Ma C, Gao C, Chen Y, Liu S. Roles of TIPE2 in hepatitis B virus-induced hepatic inflammation in humans and mice. Molecular Immunology. 48: 1203-8. PMID 21466895 DOI: 10.1016/J.Molimm.2011.03.002  0.325
2011 Zhang L, Shi Y, Wang Y, Zhu F, Wang Q, Ma C, Chen YH, Zhang L. The unique expression profile of human TIPE2 suggests new functions beyond its role in immune regulation. Molecular Immunology. 48: 1209-15. PMID 21459448 DOI: 10.1016/J.Molimm.2011.03.001  0.398
2011 Li L, Ruan Q, Hilliard B, Devirgiliis J, Karin M, Chen YH. Transcriptional regulation of the Th17 immune response by IKK(alpha). The Journal of Experimental Medicine. 208: 787-96. PMID 21402739 DOI: 10.1084/Jem.20091346  0.43
2010 Zhang X, Wang X, Song X, Liu C, Shi Y, Wang Y, Afonja O, Ma C, Chen YH, Zhang L. Programmed cell death 4 enhances chemosensitivity of ovarian cancer cells by activating death receptor pathway in vitro and in vivo. Cancer Science. 101: 2163-70. PMID 20735432 DOI: 10.1111/J.1349-7006.2010.01664.X  0.369
2010 Zhang G, Hao C, Lou Y, Xi W, Wang X, Wang Y, Qu Z, Guo C, Chen Y, Zhang Y, Liu S. Tissue-specific expression of TIPE2 provides insights into its function. Molecular Immunology. 47: 2435-42. PMID 20663561 DOI: 10.1016/J.Molimm.2010.06.016  0.388
2010 Ruan Q, Zheng SJ, Palmer S, Carmody RJ, Chen YH. Roles of Bcl-3 in the pathogenesis of murine type 1 diabetes. Diabetes. 59: 2549-57. PMID 20622172 DOI: 10.2337/Db10-0480  0.371
2010 Cui M, Wang L, Liang X, Ma X, Liu Y, Yang M, Liu K, Wei X, Zhou Z, Chen YH, Sun W. Blocking TRAIL-DR5 signaling with soluble DR5 reduces delayed neuronal damage after transient global cerebral ischemia. Neurobiology of Disease. 39: 138-47. PMID 20359534 DOI: 10.1016/J.Nbd.2010.03.018  0.317
2010 Sheedy FJ, Palsson-McDermott E, Hennessy EJ, Martin C, O'Leary JJ, Ruan Q, Johnson DS, Chen Y, O'Neill LA. Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21. Nature Immunology. 11: 141-7. PMID 19946272 DOI: 10.1038/Ni.1828  0.511
2009 Ruan Q, Kameswaran V, Tone Y, Li L, Liou HC, Greene MI, Tone M, Chen YH. Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome. Immunity. 31: 932-40. PMID 20064450 DOI: 10.1016/J.Immuni.2009.10.006  0.442
2009 Wei ZT, Zhang X, Wang XY, Gao F, Zhou CJ, Zhu FL, Wang Q, Gao Q, Ma CH, Sun WS, Fu QZ, Chen YH, Zhang LN. PDCD4 inhibits the malignant phenotype of ovarian cancer cells. Cancer Science. 100: 1408-13. PMID 19493270 DOI: 10.1111/J.1349-7006.2009.01210.X  0.376
2009 Ludwinski MW, Sun J, Hilliard B, Gong S, Xue F, Carmody RJ, DeVirgiliis J, Chen YH. Critical roles of Bim in T cell activation and T cell-mediated autoimmune inflammation in mice. The Journal of Clinical Investigation. 119: 1706-13. PMID 19411758 DOI: 10.1172/Jci37619  0.695
2009 Razmara M, Hilliard B, Ziarani AK, Murali R, Yellayi S, Ghazanfar M, Chen YH, Tykocinski ML. Fn14-TRAIL, a chimeric intercellular signal exchanger, attenuates experimental autoimmune encephalomyelitis. The American Journal of Pathology. 174: 460-74. PMID 19147815 DOI: 10.2353/Ajpath.2009.080462  0.415
2008 Palmer S, Chen YH. Bcl-3, a multifaceted modulator of NF-kappaB-mediated gene transcription. Immunologic Research. 42: 210-8. PMID 19002607 DOI: 10.1007/S12026-008-8075-4  0.367
2008 Du J, Liang X, Liu Y, Qu Z, Gao L, Han L, Liu S, Cui M, Shi Y, Zhang Z, Yu L, Cao L, Ma C, Zhang L, Chen Y, et al. Hepatitis B virus core protein inhibits TRAIL-induced apoptosis of hepatocytes by blocking DR5 expression. Cell Death and Differentiation. 16: 219-29. PMID 18927587 DOI: 10.1038/Cdd.2008.144  0.344
2008 Li H, Zhang GX, Chen Y, Xu H, Fitzgerald DC, Zhao Z, Rostami A. CD11c+CD11b+ dendritic cells play an important role in intravenous tolerance and the suppression of experimental autoimmune encephalomyelitis. Journal of Immunology (Baltimore, Md. : 1950). 181: 2483-93. PMID 18684939 DOI: 10.4049/Jimmunol.181.4.2483  0.401
2008 Sun H, Gong S, Carmody RJ, Hilliard A, Li L, Sun J, Kong L, Xu L, Hilliard B, Hu S, Shen H, Yang X, Chen YH. TIPE2, a Negative Regulator of Innate and Adaptive Immunity that Maintains Immune Homeostasis Cell. 133: 415-426. PMID 18455983 DOI: 10.1016/J.Cell.2008.03.026  0.45
2008 Razmara M, Hilliard B, Ziarani AK, Chen YH, Tykocinski ML. CTLA-4 x Ig converts naive CD4+CD25- T cells into CD4+CD25+ regulatory T cells. International Immunology. 20: 471-83. PMID 18272926 DOI: 10.1093/Intimm/Dxn007  0.348
2007 Liang X, Du J, Liu Y, Cui M, Ma C, Han L, Qu Z, Zhang Z, Sun Z, Zhang L, Chen YH, Sun W. The hepatitis B virus protein MHBs(t) sensitizes hepatoma cells to TRAIL-induced apoptosis through ERK2. Apoptosis : An International Journal On Programmed Cell Death. 12: 1827-36. PMID 17701086 DOI: 10.1007/S10495-007-0114-4  0.423
2007 Carmody RJ, Ruan Q, Palmer S, Hilliard B, Chen YH. Negative regulation of toll-like receptor signaling by NF-kappaB p50 ubiquitination blockade. Science (New York, N.Y.). 317: 675-8. PMID 17673665 DOI: 10.1126/Science.1142953  0.394
2007 Liang X, Liu Y, Zhang Q, Gao L, Han L, Ma C, Zhang L, Chen YH, Sun W. Hepatitis B virus sensitizes hepatocytes to TRAIL-induced apoptosis through Bax. Journal of Immunology (Baltimore, Md. : 1950). 178: 503-10. PMID 17182590 DOI: 10.4049/Jimmunol.178.1.503  0.347
2007 Carmody RJ, Ruan Q, Liou HC, Chen YH. Essential roles of c-Rel in TLR-induced IL-23 p19 gene expression in dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 178: 186-91. PMID 17182554 DOI: 10.4049/Jimmunol.178.1.186  0.317
2006 Hilliard A, Hilliard B, Zheng SJ, Sun H, Miwa T, Song W, Göke R, Chen YH. Translational regulation of autoimmune inflammation and lymphoma genesis by programmed cell death 4. Journal of Immunology (Baltimore, Md. : 1950). 177: 8095-102. PMID 17114484 DOI: 10.4049/Jimmunol.177.11.8095  0.459
2006 Anand S, Wang P, Yoshimura K, Choi IH, Hilliard A, Chen YH, Wang CR, Schulick R, Flies AS, Flies DB, Zhu G, Xu Y, Pardoll DM, Chen L, Tamada K. Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis. The Journal of Clinical Investigation. 116: 1045-51. PMID 16557300 DOI: 10.1172/Jci27083  0.387
2006 Gonnella PA, Chen YH, Waldner H, Weiner HL. Induction of oral tolerization in CD86 deficient mice: a role for CD86 and B cells in the up-regulation of TGF-beta. Journal of Autoimmunity. 26: 73-81. PMID 16439314 DOI: 10.1016/J.Jaut.2005.10.003  0.38
2006 Carmody RJ, Maguschak K, Chen YH. A novel mechanism of nuclear factor-kappaB regulation by adenoviral protein 14.7K. Immunology. 117: 188-95. PMID 16423054 DOI: 10.1111/J.1365-2567.2005.02277.X  0.311
2006 Gong S, Sun H, Hilliard A, Carmody R, Chen Y. PD20, A Novel Regulator of Apoptosis and Cytokine Response of Immune Cells Clinical Immunology. 119: S45. DOI: 10.1016/J.Clim.2006.04.413  0.337
2005 Heong KL, Chen YH, Johnson DE, Jahn GC, Hossain M, Hamilton RS. Debate over a GM rice trial in China. Science (New York, N.Y.). 310: 231-3; author reply . PMID 16224002 DOI: 10.1126/Science.310.5746.231B  0.362
2005 Sun J, Hilliard B, Xu L, Chen YH. Essential roles of the Fas-associated death domain in autoimmune encephalomyelitis. Journal of Immunology (Baltimore, Md. : 1950). 175: 4783-8. PMID 16177127 DOI: 10.4049/Jimmunol.175.7.4783  0.486
2005 Liang X, Sun W, Gao L, Ma C, Han L, Chen Y. Hepatitis B virus X protein modulates the apoptosis of hepatoma cell line induced by TRAIL. Science in China. Series C, Life Sciences. 48: 277-86. PMID 16092761 DOI: 10.1007/Bf03183622  0.383
2005 Murali R, Cheng X, Berezov A, Du X, Schön A, Freire E, Xu X, Chen YH, Greene MI. Disabling TNF receptor signaling by induced conformational perturbation of tryptophan-107. Proceedings of the National Academy of Sciences of the United States of America. 102: 10970-5. PMID 16043718 DOI: 10.1073/Pnas.0504301102  0.314
2005 Zheng SJ, Lamhamedi-Cherradi SE, Wang P, Xu L, Chen YH. Tumor suppressor p53 inhibits autoimmune inflammation and macrophage function. Diabetes. 54: 1423-8. PMID 15855329 DOI: 10.2337/Diabetes.54.5.1423  0.382
2005 Finnberg N, Gruber JJ, Fei P, Rudolph D, Bric A, Kim SH, Burns TF, Ajuha H, Page R, Wu GS, Chen Y, McKenna WG, Bernhard E, Lowe S, Mak T, et al. DR5 knockout mice are compromised in radiation-induced apoptosis. Molecular and Cellular Biology. 25: 2000-13. PMID 15713653 DOI: 10.1128/Mcb.25.5.2000-2013.2005  0.397
2005 Liu J, Miwa T, Hilliard B, Chen Y, Lambris JD, Wells AD, Song WC. The complement inhibitory protein DAF (CD55) suppresses T cell immunity in vivo. The Journal of Experimental Medicine. 201: 567-77. PMID 15710649 DOI: 10.1084/Jem.20040863  0.464
2005 Tan D, Johnson DA, Wu W, Zeng L, Chen YH, Chen WY, Vonderhaar BK, Walker AM. Unmodified prolactin (PRL) and S179D PRL-initiated bioluminescence resonance energy transfer between homo- and hetero-pairs of long and short human PRL receptors in living human cells. Molecular Endocrinology (Baltimore, Md.). 19: 1291-303. PMID 15695371 DOI: 10.1210/Me.2004-0304  0.431
2004 Zheng SJ, Jiang J, Shen H, Chen YH. Reduced apoptosis and ameliorated listeriosis in TRAIL-null mice. Journal of Immunology (Baltimore, Md. : 1950). 173: 5652-8. PMID 15494516 DOI: 10.4049/Jimmunol.173.9.5652  0.405
2004 Kim SH, Kim K, Kwagh JG, Dicker DT, Herlyn M, Rustgi AK, Chen Y, El-Deiry WS. Death induction by recombinant native TRAIL and its prevention by a caspase 9 inhibitor in primary human esophageal epithelial cells Journal of Biological Chemistry. 279: 40044-40052. PMID 15226295 DOI: 10.1074/Jbc.M404541200  0.364
2004 Zheng SJ, Wang P, Tsabary G, Chen YH. Critical roles of TRAIL in hepatic cell death and hepatic inflammation. The Journal of Clinical Investigation. 113: 58-64. PMID 14702109 DOI: 10.1172/Jci19255  0.41
2003 Zheng SJ, Chen YH. TRAIL, Bim, and thymic-negative selection. Immunologic Research. 28: 295-301. PMID 14713721 DOI: 10.1385/Ir:28:3:295  0.378
2003 Lamhamedi-Cherradi SE, Zheng S, Hilliard BA, Xu L, Sun J, Alsheadat S, Liou HC, Chen YH. Transcriptional regulation of type I diabetes by NF-kappa B. Journal of Immunology (Baltimore, Md. : 1950). 171: 4886-92. PMID 14568969 DOI: 10.4049/Jimmunol.171.9.4886  0.381
2003 Lamhamedi-Cherradi SE, Zheng S, Tisch RM, Chen YH. Critical roles of tumor necrosis factor-related apoptosis-inducing ligand in type 1 diabetes. Diabetes. 52: 2274-8. PMID 12941766 DOI: 10.2337/Diabetes.52.9.2274  0.384
2003 Xu L, Hilliard B, Carmody RJ, Tsabary G, Shin H, Christianson DW, Chen YH. Arginase and autoimmune inflammation in the central nervous system. Immunology. 110: 141-8. PMID 12941151 DOI: 10.1046/J.1365-2567.2003.01713.X  0.356
2003 Mi QS, Ly D, Lamhamedi-Cherradi SE, Salojin KV, Zhou L, Grattan M, Meagher C, Zucker P, Chen YH, Nagle J, Taub D, Delovitch TL. Blockade of tumor necrosis factor-related apoptosis-inducing ligand exacerbates type 1 diabetes in NOD mice. Diabetes. 52: 1967-75. PMID 12882912 DOI: 10.2337/Diabetes.52.8.1967  0.446
2003 Chen YH. Genes and genomics of autoimmune inflammation: from Rel to TRAIL. Immunologic Research. 27: 169-78. PMID 12857966 DOI: 10.1385/Ir:27:2-3:169  0.329
2003 Lamhamedi-Cherradi SE, Zheng SJ, Maguschak KA, Peschon J, Chen YH. Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL-/- mice. Nature Immunology. 4: 255-60. PMID 12577054 DOI: 10.1038/Ni894  0.45
2002 Hilliard BA, Mason N, Xu L, Sun J, Lamhamedi-Cherradi SE, Liou HC, Hunter C, Chen YH. Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation. The Journal of Clinical Investigation. 110: 843-50. PMID 12235116 DOI: 10.1172/Jci15254  0.421
2002 Göke A, Göke R, Knolle A, Trusheim H, Schmidt H, Wilmen A, Carmody R, Göke B, Chen YH. DUG is a novel homologue of translation initiation factor 4G that binds eIF4A. Biochemical and Biophysical Research Communications. 297: 78-82. PMID 12220511 DOI: 10.1016/S0006-291X(02)02129-0  0.357
2002 Chen Y, Ma Y, Chen Y. Roles of cytotoxic T-lymphocyte-associated antigen-4 in the inductive phase of oral tolerance. Immunology. 105: 171-80. PMID 11872092 DOI: 10.1046/J.1365-2567.2002.01348.X  0.43
2001 Chern CL, Huang RF, Chen YH, Cheng JT, Liu TZ. Folate deficiency-induced oxidative stress and apoptosis are mediated via homocysteine-dependent overproduction of hydrogen peroxide and enhanced activation of NF-kappaB in human Hep G2 cells. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 55: 434-42. PMID 11686576 DOI: 10.1016/S0753-3322(01)00095-6  0.317
2001 Göke R, Göke A, Göke B, El-Deiry WS, Chen Y. Pioglitazone inhibits growth of carcinoid cells and promotes TRAIL-induced apoptosis by induction of p21waf1/cip1 Digestion. 64: 75-80. PMID 11684819 DOI: 10.1159/000048843  0.403
2001 Lamhamedi-Cherradi SE, Chen Y. Fas (CD95, Apo-1) ligand gene transfer. Journal of Clinical Immunology. 21: 24-9. PMID 11321235 DOI: 10.1023/A:1006784830473  0.325
2001 Kim K, Takimoto R, Dicker DT, Chen Y, Gazitt Y, El-Deiry WS. Enhanced TRAIL sensitivity by p53 overexpression in human cancer but not normal cell lines International Journal of Oncology. 18: 241-247. PMID 11172588 DOI: 10.3892/Ijo.18.2.241  0.34
2001 Hilliard B, Wilmen A, Seidel C, Liu TT, Göke R, Chen Y. Roles of TNF-Related Apoptosis-Inducing Ligand in Experimental Autoimmune Encephalomyelitis Journal of Immunology. 166: 1314-1319. PMID 11145715 DOI: 10.4049/Jimmunol.166.2.1314  0.626
2000 Chen Y, Song K, Eck SL, Chen Y. An intra-Peyer's patch gene transfer model for studying mucosal tolerance: distinct roles of B7 and IL-12 in mucosal T cell tolerance. Journal of Immunology. 165: 3145-3153. PMID 10975828 DOI: 10.4049/Jimmunol.165.6.3145  0.356
2000 Liu TT, Hilliard B, Samoilova EB, Chen Y. Differential roles of Fas ligand in spontaneous and actively induced autoimmune encephalomyelitis. Clinical Immunology. 95: 203-211. PMID 10866127 DOI: 10.1006/Clim.2000.4861  0.609
2000 Göke R, Göke A, Göke B, Chen Y. Regulation of TRAIL-induced apoptosis by transcription factors. Cellular Immunology. 201: 77-82. PMID 10831316 DOI: 10.1006/Cimm.2000.1650  0.334
2000 Song K, Chen Y, Göke R, Wilmen A, Seidel C, Göke A, Hilliard B, Chen Y. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an inhibitor of autoimmune inflammation and cell cycle progression. The Journal of Experimental Medicine. 191: 1095-104. PMID 10748228 DOI: 10.1084/Jem.191.7.1095  0.434
1999 Zhang G, Liu TT, Ventura ES, Chen Y, Rostami A. Reversal of spontaneous progressive autoimmune encephalomyelitis by myelin basic protein-induced clonal deletion. Autoimmunity. 31: 219-227. PMID 10789987 DOI: 10.3109/08916939908994067  0.442
1999 Chirmule N, Moscioni AD, Qian Y, Qian R, Chen Y, Wilson JM. Fas-Fas ligand interactions play a major role in effector functions of cytotoxic T lymphocytes after adenovirus vector-mediated gene transfer. Human Gene Therapy. 10: 259-69. PMID 10022550 DOI: 10.1089/10430349950019048  0.423
1998 Samoilova EB, Horton JL, Chen Y. Experimental Autoimmune Encephalomyelitis in Intercellular Adhesion Molecule-1-Deficient Mice Cellular Immunology. 190: 83-89. PMID 9826450 DOI: 10.1006/Cimm.1998.1395  0.448
1998 Samoilova EB, Horton JL, Chen Y. Acceleration of experimental autoimmune encephalomyelitis in interleukin-10-deficient mice: roles of interleukin-10 in disease progression and recovery. Cellular Immunology. 188: 118-124. PMID 9756642 DOI: 10.1006/Cimm.1998.1365  0.344
1998 Inobe J, Slavin AJ, Komagata Y, Chen Y, Liu L, Weiner HL. IL‐4 is a differentiation factor for transforming growth factor‐β secreting Th3 cells and oral administration of IL‐4 enhances oral tolerance in experimental allergic encephalomyelitis European Journal of Immunology. 28: 2780-2790. PMID 9754565 DOI: 10.1002/(Sici)1521-4141(199809)28:09<2780::Aid-Immu2780>3.0.Co;2-J  0.351
1998 Judge TA, Desai NM, Yang Z, Rostami S, Alonso L, Zhang H, Chen Y, Markman JF, DeMateo RP, Barker CF, Naji A, Turka LA. Utility of adenoviral-mediated Fas ligand gene transfer to modulate islet allograft survival. Transplantation. 66: 426-34. PMID 9734483 DOI: 10.1097/00007890-199808270-00003  0.354
1998 Samoilova EB, Horton JL, Zhang H, Khoury SJ, Weiner HL, Chen Y. CTLA-4 is required for the induction of high dose oral tolerance. International Immunology. 10: 491-8. PMID 9620605 DOI: 10.1093/Intimm/10.4.491  0.398
1998 Chen Y, Hancock WW, Marks R, Gonnella P, Weiner HL. Mechanisms of recovery from experimental autoimmune encephalomyelitis: T cell deletion and immune deviation in myelin basic protein T cell receptor transgenic mice. Journal of Neuroimmunology. 82: 149-59. PMID 9585811 DOI: 10.1016/S0165-5728(97)00193-8  0.459
1998 Chen Y. Autoimmunity, immunologic tolerance, and gene therapy Immunologic Research. 17: 33-40. PMID 9479565 DOI: 10.1007/Bf02786428  0.439
1997 Samoilova EB, Horton JL, Bassiri H, Zhang H, Linsley PS, Carding SR, Chen Y. B7 blockade prevents activation-induced cell death of thymocytes. International Immunology. 9: 1663-1668. PMID 9418127 DOI: 10.1093/Intimm/9.11.1663  0.433
1997 Zhang H, Yang Y, Horton JL, Samoilova EB, Judge TA, Turka LA, Wilson JM, Chen Y. Amelioration of collagen-induced arthritis by CD95 (Apo-1/Fas)-ligand gene transfer. The Journal of Clinical Investigation. 100: 1951-7. PMID 9329958 DOI: 10.1172/Jci119726  0.418
1997 Samoilova EB, Horton JL, Zhang H, Chen Y. CD40L blockade prevents autoimmune encephalomyelitis and hampers TH1 but not TH2 pathway of T cell differentiation. Journal of Molecular Medicine. 75: 603-608. PMID 9297628 DOI: 10.1007/S001090050145  0.425
1997 Chen Y, Inobe J, Weiner HL. Inductive Events in Oral Tolerance in the TCR Transgenic Adoptive Transfer Model Cellular Immunology. 178: 62-68. PMID 9184699 DOI: 10.1006/Cimm.1997.1119  0.391
1997 Johnson D, Cohen P, Chen MX, Chen YH, Cohen PT. Identification of the regions on the M110 subunit of protein phosphatase 1M that interact with the M21 subunit and with myosin. European Journal of Biochemistry / Febs. 244: 931-9. PMID 9108268 DOI: 10.1111/J.1432-1033.1997.00931.X  0.357
1996 Johnson DF, Moorhead G, Caudwell FB, Cohen P, Chen YH, Chen MX, Cohen PT. Identification of protein-phosphatase-1-binding domains on the glycogen and myofibrillar targetting subunits. European Journal of Biochemistry / Febs. 239: 317-25. PMID 8706735 DOI: 10.1111/J.1432-1033.1996.0317U.X  0.379
1996 Inobe J, Chen Y, Weiner HL. In Vivo Administration of IL‐4 Induces TGF‐β‐producing Cells and Protects Animals from Experimental Autoimmune Encephalomyelitis Annals of the New York Academy of Sciences. 778: 390-392. PMID 8611000 DOI: 10.1111/J.1749-6632.1996.Tb21153.X  0.382
1996 Nelson PA, Akselband Y, Dearborn SM, Al-Sabbagh A, Tian ZJ, Gonnella PA, Zamvil SS, Chen Y, Weiner HL. Effect of oral beta interferon on subsequent immune responsiveness. Annals of the New York Academy of Sciences. 778: 145-55. PMID 8610968 DOI: 10.1111/J.1749-6632.1996.Tb21123.X  0.318
1996 Chen YH, Weiner HL. Dose-dependent activation and deletion of antigen-specific T cells following oral tolerance. Annals of the New York Academy of Sciences. 778: 111-121. PMID 8610965 DOI: 10.1111/J.1749-6632.1996.Tb21120.X  0.343
1996 Chen Y, Inobe JI, Kuchroo VK, Baron JL, Janeway CA, Weiner HL. Oral tolerance in myelin basic protein T-cell receptor transgenic mice: Suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells Proceedings of the National Academy of Sciences of the United States of America. 93: 388-391. PMID 8552644 DOI: 10.1073/Pnas.93.1.388  0.432
1995 Chen Y, Inobe J, Marks R, Gonnella P, Kuchroo VK, Weiner HL. Peripheral deletion of antigen-reactive T cells in oral tolerance. Nature. 376: 177-80. PMID 7603570 DOI: 10.1038/376177A0  0.412
1994 Chen Y, Kuchroo VK, Inobe J, Hafler DA, Weiner HL. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science (New York, N.Y.). 265: 1237-40. PMID 7520605 DOI: 10.1126/Science.7520605  0.445
1994 Chen Y, Kuchroo V, Weiner HL. Myelin basic protein (MBP)-specific TGFβ-secreting CD4+ T-cell clones derived from orally tolerized animals suppress experimental autoimmune encephalomyelitis Journal of Neuroimmunology. 54: 205. DOI: 10.1016/0165-5728(94)90580-0  0.353
1993 Chen Y, Mohapatra S, Mohapatra SS, Sehon AH. Cytokine gene expression of CD8+ suppressor T cells induced by tolerogenic conjugates of antigen and mPEG Cellular Immunology. 149: 409-421. PMID 8330317 DOI: 10.1006/Cimm.1993.1166  0.378
1992 Chen Y, Takata M, Maiti PK, Rector ES, Sehon AH. Characterization of suppressor T cell clones derived from a mouse tolerized with conjugates of ovalbumin and monomethoxypolyethylene glycol. Cellular Immunology. 142: 16-27. PMID 1534037 DOI: 10.1016/0008-8749(92)90265-Q  0.422
1991 Takata M, Maiti PK, Bitoh S, Holford-Strevens V, Kierek-Jaszczuk D, Chen Y, Lang GM, Sehon AH. Downregulation of helper T cells by an antigen-specific monoclonal Ts factor. Cellular Immunology. 137: 139-49. PMID 1832086 DOI: 10.1016/0008-8749(91)90064-I  0.416
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