Marvin C. Gershengorn - Publications

Affiliations: 
Weill Cornell Medical College, New York, NY, United States 
Area:
Pharmacology, General Biophysics, Biochemistry

142 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Krieger CC, Boutin A, Neumann S, Gershengorn MC. Proximity ligation assay to study TSH receptor homodimerization and crosstalk with IGF-1 receptors in human thyroid cells. Frontiers in Endocrinology. 13: 989626. PMID 36246873 DOI: 10.3389/fendo.2022.989626  0.321
2020 Boutin A, Gershengorn MC, Neumann S. β-Arrestin 1 in Thyrotropin Receptor Signaling in Bone: Studies in Osteoblast-Like Cells. Frontiers in Endocrinology. 11: 312. PMID 32508750 DOI: 10.3389/fendo.2020.00312  0.327
2020 Krieger CC, Neumann S, Gershengorn MC. TSH/IGF1 receptor crosstalk: Mechanism and clinical implications. Pharmacology & Therapeutics. 107502. PMID 32061922 DOI: 10.1016/j.pharmthera.2020.107502  0.344
2019 Krieger CC, Boutin A, Jang D, Morgan SJ, Banga JP, Kahaly GJ, Klubo-Gwiezdzinska J, Neumann S, Gershengorn MC. Arrestin-β-1 Physically Scaffolds TSH and IGF1 Receptors to Enable Crosstalk. Endocrinology. 160: 1468-1479. PMID 31127272 DOI: 10.1210/en.2019-00055  0.353
2019 Davenport AP, Gershengorn M, Hills R. Thyrotropin-releasing hormone receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f63/2019.4  0.362
2019 Costagliola S, Dias JA, Gershengorn M, Segaloff DL, Themmen AP, Vassart G. Glycoprotein hormone receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f30/2019.4  0.339
2018 Krieger CC, Morgan SJ, Neumann S, Gershengorn MC. Thyroid Stimulating Hormone (TSH)/Insulin-like Growth Factor 1 (IGF1) Receptor Cross-talk in Human Cells. Current Opinion in Endocrine and Metabolic Research. 2: 29-33. PMID 30547142 DOI: 10.1016/j.coemr.2018.01.007  0.369
2018 Marcus-Samuels B, Krieger CC, Boutin A, Kahaly G, Neumann S, Gershengorn MC. Evidence that Graves' Ophthalmopathy Immunoglobulins Do Not Directly Activate IGF-1 Receptors. Thyroid : Official Journal of the American Thyroid Association. PMID 29631510 DOI: 10.1089/thy.2018.0089  0.308
2017 Krieger CC, Perry JD, Morgan SJ, Kahaly GJ, Gershengorn MC. TSH/IGF-1 Receptor Cross-talk Rapidly Activates Extracellular Signal-regulated Kinases in Multiple Cell Types. Endocrinology. PMID 28938449 DOI: 10.1210/en.2017-00528  0.373
2016 Morgan SJ, Neumann S, Marcus-Samuels B, Gershengorn MC. TSH and IGF-1 receptor crosstalk upregulates sodium-iodide symporter expression in primary cultures of human thyrocytes. Thyroid : Official Journal of the American Thyroid Association. PMID 27638195 DOI: 10.1089/thy.2016.0323  0.313
2014 Segal L, Katz LS, Lupu-Meiri M, Shapira H, Sandbank J, Gershengorn MC, Oron Y. Proteinase-activated receptors differentially modulate in vitro invasion of human pancreatic adenocarcinoma PANC-1 cells in correlation with changes in the expression of CDC42 protein. Pancreas. 43: 103-8. PMID 23921961 DOI: 10.1097/MPA.0b013e31829f0b81  0.308
2013 Geras-Raaka E, Neumann S, Gershengorn MC. Persistent cAMP signaling by TSH receptors revealed by phosphodiesterase inhibition. Thyroid : Official Journal of the American Thyroid Association. 23: 1484-9. PMID 23713896 DOI: 10.1089/thy.2013.0089  0.338
2012 Thirunarayanan N, Raaka BM, Gershengorn MC. Taltirelin is a superagonist at the human thyrotropin-releasing hormone receptor. Frontiers in Endocrinology. 3: 120. PMID 23087672 DOI: 10.3389/fendo.2012.00120  0.388
2012 Boutin A, Allen MD, Neumann S, Gershengorn MC. Persistent signaling by thyrotropin-releasing hormone receptors correlates with G-protein and receptor levels. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 3473-82. PMID 22593547 DOI: 10.1096/fj.12-207860  0.371
2011 Allen MD, Neumann S, Gershengorn MC. Small-molecule thyrotropin receptor agonist activates naturally occurring thyrotropin-insensitive mutants and reveals their distinct cyclic adenosine monophosphate signal persistence. Thyroid : Official Journal of the American Thyroid Association. 21: 907-12. PMID 21745101 DOI: 10.1089/thy.2011.0025  0.311
2011 Allen MD, Neumann S, Gershengorn MC. Occupancy of both sites on the thyrotropin (TSH) receptor dimer is necessary for phosphoinositide signaling. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 3687-94. PMID 21705666 DOI: 10.1096/fj.11-188961  0.377
2011 Boutin A, Allen MD, Geras-Raaka E, Huang W, Neumann S, Gershengorn MC. Thyrotropin receptor stimulates internalization-independent persistent phosphoinositide signaling. Molecular Pharmacology. 80: 240-6. PMID 21525174 DOI: 10.1124/mol.111.072157  0.339
2011 Neumann S, Eliseeva E, McCoy JG, Napolitano G, Giuliani C, Monaco F, Huang W, Gershengorn MC. A new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptor. The Journal of Clinical Endocrinology and Metabolism. 96: 548-54. PMID 21123444 DOI: 10.1210/jc.2010-1935  0.314
2010 Neumann S, Raaka BM, Gershengorn MC. Constitutively active thyrotropin and thyrotropin-releasing hormone receptors and their inverse agonists. Methods in Enzymology. 485: 147-60. PMID 21050916 DOI: 10.1016/B978-0-12-381296-4.00009-9  0.389
2010 Neumann S, Geras-Raaka E, Marcus-Samuels B, Gershengorn MC. Persistent cAMP signaling by thyrotropin (TSH) receptors is not dependent on internalization. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 3992-9. PMID 20538910 DOI: 10.1096/fj.10-161745  0.367
2010 Neumann S, Huang W, Eliseeva E, Titus S, Thomas CJ, Gershengorn MC. A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. Endocrinology. 151: 3454-9. PMID 20427476 DOI: 10.1210/En.2010-0199  0.337
2010 Kleinau G, Haas AK, Neumann S, Worth CL, Hoyer I, Furkert J, Rutz C, Gershengorn MC, Schülein R, Krause G. Signaling-sensitive amino acids surround the allosteric ligand binding site of the thyrotropin receptor. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 2347-54. PMID 20179143 DOI: 10.1096/fj.09-149146  0.358
2009 Neumann S, Huang W, Titus S, Krause G, Kleinau G, Alberobello AT, Zheng W, Southall NT, Inglese J, Austin CP, Celi FS, Gavrilova O, Thomas CJ, Raaka BM, Gershengorn MC. Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice. Proceedings of the National Academy of Sciences of the United States of America. 106: 12471-6. PMID 19592511 DOI: 10.1073/Pnas.0904506106  0.34
2009 Couty JP, Lupu-Meiri M, Oron Y, Gershengorn MC. Kaposi's sarcoma-associated herpesvirus-G protein-coupled receptor-expressing endothelial cells exhibit reduced migration and stimulated chemotaxis by chemokine inverse agonists. The Journal of Pharmacology and Experimental Therapeutics. 329: 1142-7. PMID 19258523 DOI: 10.1124/jpet.108.147686  0.362
2009 Sum CS, Tikhonova IG, Costanzi S, Gershengorn MC. Two arginine-glutamate ionic locks near the extracellular surface of FFAR1 gate receptor activation. The Journal of Biological Chemistry. 284: 3529-36. PMID 19068482 DOI: 10.1074/Jbc.M806987200  0.311
2009 Mulla CM, Geras-Raaka E, Raaka BM, Gershengorn MC. High levels of thyrotropin-releasing hormone receptors activate programmed cell death in human pancreatic precursors. Pancreas. 38: 197-202. PMID 18948837 DOI: 10.1097/MPA.0b013e31818d14a8  0.32
2008 Neumann S, Kleinau G, Costanzi S, Moore S, Jiang JK, Raaka BM, Thomas CJ, Krause G, Gershengorn MC. A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism. Endocrinology. 149: 5945-50. PMID 18669595 DOI: 10.1210/En.2008-0836  0.313
2008 Engel S, Skoumbourdis AP, Childress J, Neumann S, Deschamps JR, Thomas CJ, Colson AO, Costanzi S, Gershengorn MC. A virtual screen for diverse ligands: Discovery of selective G protein-coupled receptor antagonists Journal of the American Chemical Society. 130: 5115-5123. PMID 18357984 DOI: 10.1021/Ja077620L  0.321
2008 Deflorian F, Engel S, Colson AO, Raaka BM, Gershengorn MC, Costanzi S. Understanding the structural and functional differences between mouse thyrotropin-releasing hormone receptors 1 and 2 Proteins: Structure, Function and Genetics. 71: 783-794. PMID 17979196 DOI: 10.1002/Prot.21763  0.334
2007 Engel S, Gershengorn MC. Thyrotropin-releasing hormone and its receptors--a hypothesis for binding and receptor activation. Pharmacology & Therapeutics. 113: 410-9. PMID 17123625 DOI: 10.1016/j.pharmthera.2006.09.004  0.359
2006 Moore S, Jaeschke H, Kleinau G, Neumann S, Costanzi S, Jiang JK, Childress J, Raaka BM, Colson A, Paschke R, Krause G, Thomas CJ, Gershengorn MC. Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: Structure-activity relationships and selective binding patterns Journal of Medicinal Chemistry. 49: 3888-3896. PMID 16789744 DOI: 10.1021/Jm060247S  0.323
2006 Engel S, Neumann S, Kaur N, Monga V, Jain R, Northup J, Gershengorn MC. Low affinity analogs of thyrotropin-releasing hormone are super-agonists. The Journal of Biological Chemistry. 281: 13103-9. PMID 16551618 DOI: 10.1074/Jbc.M600440200  0.375
2006 Jäschke H, Neumann S, Moore S, Thomas CJ, Colson AO, Costanzi S, Kleinau G, Jiang JK, Paschke R, Raaka BM, Krause G, Gershengorn MC. A low molecular weight agonist signals by binding to the transmembrane domain of thyroid-stimulating hormone receptor (TSHR) and luteinizing hormone/chorionic gonadotropin receptor (LHCGR) Journal of Biological Chemistry. 281: 9841-9844. PMID 16488885 DOI: 10.1074/Jbc.C600014200  0.36
2006 Colson AO, Gershengorn MC. Thyrotropin-releasing hormone analogs Mini-Reviews in Medicinal Chemistry. 6: 221-226. PMID 16472189 DOI: 10.2174/138955706775476019  0.392
2006 Wei C, Geras-Raaka E, Marcus-Samuels B, Oron Y, Gershengorn MC. Trypsin and thrombin accelerate aggregation of human endocrine pancreas precursor cells. Journal of Cellular Physiology. 206: 322-8. PMID 16021635 DOI: 10.1002/jcp.20459  0.319
2005 Couty JP, Gershengorn MC. G-protein-coupled receptors encoded by human herpesviruses Trends in Pharmacological Sciences. 26: 405-411. PMID 15990176 DOI: 10.1016/j.tips.2005.06.004  0.36
2005 Du D, Raaka BM, Grimberg H, Lupu-Meiri M, Oron Y, Gershengorn MC. Carboxyl tail cysteine mutants of the thyrotropin-releasing hormone receptor type 1 exhibit constitutive signaling: role of palmitoylation. Molecular Pharmacology. 68: 204-9. PMID 15833733 DOI: 10.1124/mol.105.012641  0.323
2005 Huang W, Osman R, Gershengorn MC. Agonist-induced conformational changes in thyrotropin-releasing hormone receptor type I: disulfide cross-linking and molecular modeling approaches. Biochemistry. 44: 2419-31. PMID 15709754 DOI: 10.1021/Bi048808+  0.305
2005 Jiang JK, Thomas CJ, Neumann S, Lu X, Rice KC, Gershengorn MC. 1-(Phenyl)isoquinoline carboxamides: a novel class of subtype selective inhibitors of thyrotropin-releasing hormone (TRH) receptors. Bioorganic & Medicinal Chemistry Letters. 15: 733-6. PMID 15664847 DOI: 10.1016/J.Bmcl.2004.11.017  0.332
2004 Couty JP, Gershengorn MC. Insights into the viral G protein-coupled receptor encoded by human herpesvirus type 8 (HHV-8). Biology of the Cell / Under the Auspices of the European Cell Biology Organization. 96: 349-54. PMID 15207903 DOI: 10.1016/j.biolcel.2004.03.011  0.397
2003 Lu X, Bidaud I, Ladram A, Gershengorn MC. Pharmacological studies of thyrotropin-releasing hormone (TRH) receptors from Xenopus laevis: is xTRHR3 a TRH receptor? Endocrinology. 144: 1842-6. PMID 12697690 DOI: 10.1210/en.2002-221074  0.371
2003 Sun Y, Lu X, Gershengorn MC. Thyrotropin-releasing hormone receptors - Similarities and differences Journal of Molecular Endocrinology. 30: 87-97. PMID 12683933 DOI: 10.1677/jme.0.0300087  0.342
2002 Sun Y, Gershengorn MC. Correlation between basal signaling and internalization of thyrotropin-releasing hormone receptors: evidence for involvement of similar receptor conformations. Endocrinology. 143: 2886-92. PMID 12130552 DOI: 10.1210/endo.143.8.8940  0.381
2001 Harder SN, Lu X, Wang W, Buck F, Gershengorn MC, Bruhn TO. Regulator of G Protein Signaling 4 Suppresses Basal and Thyrotropin Releasing-Hormone (TRH)-Stimulated Signaling by Two Mouse TRH Receptors, TRH-R1 and TRH-R2. Endocrinology. 142: 1188-1194. PMID 28201422 DOI: 10.1210/Endo.142.3.8019  0.388
2001 Couty JP, Geras-Raaka E, Weksler BB, Gershengorn MC. Kaposi's Sarcoma-associated Herpesvirus G Protein-coupled Receptor Signals through Multiple Pathways in Endothelial Cells Journal of Biological Chemistry. 276: 33805-33811. PMID 11448967 DOI: 10.1074/Jbc.M104631200  0.45
2001 Gershengorn MC, Osman R. Minireview: Insights into G protein-coupled receptor function using molecular models. Endocrinology. 142: 2-10. PMID 11145559 DOI: 10.1210/Endo.142.1.7919  0.382
2001 Lupu-Meiri M, Silver RB, Simons AH, Gershengorn MC, Oron Y. Constitutive signaling by Kaposi's sarcoma-associated herpesvirus G-protein-coupled receptor desensitizes calcium mobilization by other receptors. The Journal of Biological Chemistry. 276: 7122-8. PMID 11116138 DOI: 10.1074/Jbc.M006359200  0.504
2001 Ho HH, Ganeshalingam N, Rosenhouse-Dantsker A, Osman R, Gershengorn MC. Charged residues at the intracellular boundary of transmembrane helices 2 and 3 independently affect constitutive activity of Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. The Journal of Biological Chemistry. 276: 1376-82. PMID 11031271 DOI: 10.1074/Jbc.M007885200  0.324
2000 Buck F, Wang W, Harder S, Brathwaite C, Bruhn TO, Gershengorn MC. Juxtamembrane regions in the third intracellular loop of the thyrotropin-releasing hormone receptor type 1 are important for coupling to Gq. Endocrinology. 141: 3717-22. PMID 11014227 DOI: 10.1210/Endo.141.10.7716  0.478
2000 Cesarman E, Mesri EA, Gershengorn MC. Viral G protein-coupled receptor and Kaposi's sarcoma: A model of paracrine neoplasia? Journal of Experimental Medicine. 191: 417-421. PMID 10662787 DOI: 10.1084/Jem.191.3.417  0.371
2000 O'Dowd BF, Lee DK, Huang W, Nguyen T, Cheng R, Liu Y, Wang B, Gershengorn MC, George SR. TRH-R2 exhibits similar binding and acute signaling but distinct regulation and anatomic distribution compared with TRH-R1. Molecular Endocrinology (Baltimore, Md.). 14: 183-93. PMID 10628757 DOI: 10.1210/Mend.14.1.0407  0.382
1999 Ho HH, Du D, Gershengorn MC. The N terminus of Kaposi's sarcoma-associated herpesvirus G protein- coupled receptor is necessary for high affinity chemokine binding but not for constitutive activity Journal of Biological Chemistry. 274: 31327-31332. PMID 10531332 DOI: 10.1074/Jbc.274.44.31327  0.41
1999 Wang W, Gershengorn MC. Rat TRH receptor type 2 exhibits higher basal signaling activity than TRH receptor type 1 Endocrinology. 140: 4916-4919. PMID 10499553 DOI: 10.1210/Endo.140.10.7159  0.401
1999 Grimberg H, Zaltsman I, Lupu-Meiri M, Gershengorn MC, Oron Y. Inverse agonist abolishes desensitization of a constitutively active mutant of thyrotropin-releasing hormone receptor: Role of cellular calcium and protein kinase C British Journal of Pharmacology. 126: 1097-1106. PMID 10204996 DOI: 10.1038/Sj.Bjp.0702415  0.47
1999 Ho HH, Gilbert MT, Nussenzveig DR, Gershengorn MC. Glycosylation is important for binding to human calcitonin receptors. Biochemistry. 38: 1866-72. PMID 10026267 DOI: 10.1021/Bi981195E  0.601
1998 Geras-Raaka E, Varma A, Clark-Lewis I, Gershengorn MC. Kaposi's sarcoma-associated herpesvirus (KSHV) chemokine vMIP-II and human SDF-1alpha inhibit signaling by KSHV G protein-coupled receptor. Biochemical and Biophysical Research Communications. 253: 725-7. PMID 9918794 DOI: 10.1006/Bbrc.1998.9557  0.607
1998 Kirby DA, Wang W, Gershengorn MC, Rivier JE. Analogs of thyrotropin-releasing hormone using an aminoglycine-based template Peptides. 19: 1679-1683. PMID 9880072 DOI: 10.1016/S0196-9781(98)00124-7  0.326
1998 Chu W, Perlman JH, Gershengorn MC, Moeller KD. Thyrotropin releasing hormone analogs: A building block approach to the construction of tetracyclic peptidomimetics Bioorganic and Medicinal Chemistry Letters. 8: 3093-3096. PMID 9873682 DOI: 10.1016/S0960-894X(98)00567-8  0.427
1998 Colson AO, Perlman JH, Jinsi-Parimoo A, Nussenzveig DR, Osman R, Gershengorn MC. A hydrophobic cluster between transmembrane helices 5 and 6 constrains the thyrotropin-releasing hormone receptor in an inactive conformation. Molecular Pharmacology. 54: 968-78. PMID 9855624 DOI: 10.1124/Mol.54.6.968  0.4
1998 Gershengorn MC, Geras-Raaka E, Varma A, Clark-Lewis I. Chemokines activate Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor in mammalian cells in culture. The Journal of Clinical Investigation. 102: 1469-72. PMID 9788958 DOI: 10.1172/Jci4461  0.634
1998 Sun YM, Millar RP, Ho H, Gershengorn MC, Illing N. Cloning and characterization of the chicken thyrotropin-releasing hormone receptor Endocrinology. 139: 3390-3398. PMID 9681487 DOI: 10.1210/Endo.139.8.6133  0.471
1998 Geras-Raaka E, Varma A, Ho H, Clark-Lewis I, Gershengorn MC. Human interferon-gamma-inducible protein 10 (IP-10) inhibits constitutive signaling of Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. The Journal of Experimental Medicine. 188: 405-8. PMID 9670053 DOI: 10.1084/Jem.188.2.405  0.598
1998 Colson AO, Perlman JH, Smolyar A, Gershengorn MC, Osman R. Static and dynamic roles of extracellular loops in G-protein-coupled receptors: a mechanism for sequential binding of thyrotropin-releasing hormone to its receptor. Biophysical Journal. 74: 1087-100. PMID 9512011 DOI: 10.1016/S0006-3495(98)77827-0  0.417
1998 Geras-Raaka E, Arvanitakis L, Bais C, Cesarman E, Mesri EA, Gershengorn MC. Inhibition of constitutive signaling of Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor by protein kinases in mammalian cells in culture. The Journal of Experimental Medicine. 187: 801-6. PMID 9480990 DOI: 10.1084/Jem.187.5.801  0.498
1998 Geras-Raaka E, Varma A, Clark-Lewis I, Gershengorn MC. CHEMOKINE HUIP-10 INHIBITS CONSTITUTIVE SIGNALING OF KSHV G-PROTEIN-COUPLED RECEPTOR AND PROLIFERATION OF KSHV-INFECTED HUMAN B-CELLS. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 17: A27. DOI: 10.1097/00042560-199804010-00080  0.583
1998 Bais C, Santomasso B, Coso O, Arvanitakis L, Raaka EG, Gutkind JS, Asch AS, Cesarman E, Gershengorn MC, Mesri EA. THE KSHV/HHV 8 G PROTEIN COUPLED RECEPTOR IS A VIRAL ONCOGENE AND ANGIOGENESIS ACTIVATOR Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 17: A27. DOI: 10.1097/00042560-199804010-00079  0.315
1998 Bais C, Santomasso B, Coso O, Arvanitakis L, Raaka EG, Gutkind JS, Asch AS, Cesarman E, Gershengorn MC, Mesri EA. G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator Nature. 392: 210-210. DOI: 10.1038/32472  0.308
1998 Arvanitakis L, Geras-Raaka E, Gershengorn MC. Constitutively signaling G-proteincoupled receptors and human disease Trends in Endocrinology and Metabolism. 9: 27-31. DOI: 10.1016/S1043-2760(98)00007-1  0.429
1997 Perlman JH, Colson AO, Jain R, Czyzewski B, Cohen LA, Osman R, Gershengorn MC. Role of the extracellular loops of the thyrotropin-releasing hormone receptor: evidence for an initial interaction with thyrotropin-releasing hormone. Biochemistry. 36: 15670-6. PMID 9398295 DOI: 10.1021/Bi9713310  0.303
1997 Perlman JH, Colson AO, Wang W, Bence K, Osman R, Gershengorn MC. Interactions between conserved residues in transmembrane helices 1, 2, and 7 of the thyrotropin-releasing hormone receptor. The Journal of Biological Chemistry. 272: 11937-42. PMID 9115256 DOI: 10.1074/Jbc.272.18.11937  0.431
1997 Jinsi-Parimoo A, Gershengorn MC. Constitutive activity of native thyrotropin-releasing hormone receptors revealed using a protein kinase C-responsive reporter gene Endocrinology. 138: 1471-1475. PMID 9075704 DOI: 10.1210/Endo.138.4.5059  0.485
1997 Cohen DP, Thaw CN, Varma A, Gershengorn MC, Nussenzveig DR. Human calcitonin receptors exhibit agonist-independent (constitutive) signaling activity. Endocrinology. 138: 1400-5. PMID 9075694 DOI: 10.1210/Endo.138.4.5046  0.635
1997 Arvanitakis L, Geras-Raaka E, Varma A, Gershengorn MC, Cesarman E. Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation. Nature. 385: 347-50. PMID 9002520 DOI: 10.1038/385347A0  0.636
1997 Dermer SJ, Cohen DP, Thaw CN, Nussenzveig DR, Gershengorn MC. Intracellular retention and rapid degradation of human calcitonin receptors overexpressed in COS cells. Endocrinology. 137: 5502-8. PMID 8940377 DOI: 10.1210/Endo.137.12.8940377  0.426
1997 Arvanitakis L, Geras-Raaka E, Nador RG, Varma A, Gershengorn MC, Cesarman E. KSHV/HHV 8 ENCODES A CONSTITUTIVELY ACTIVE G. PROTEINCOUPLED RECEPTOR LINKED TO CELL PROLIFERATION Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology. 14: A37. DOI: 10.1097/00042560-199704010-00125  0.585
1996 Cohen DP, Nussenzveig DR, Gershengorn MC. Iodocalcitonin binds to human calcitonin receptors with higher affinity than calcitonin Endocrinology. 137: 4507-4510. PMID 8828514 DOI: 10.1210/Endo.137.10.8828514  0.384
1996 Perlman JH, Laakkonen LJ, Guarnieri F, Osman R, Gershengorn MC. A refined model of the thyrotropin-releasing hormone (TRH) receptor binding pocket. Experimental analysis and energy minimization of the complex between TRH and TRH receptor. Biochemistry. 35: 7643-50. PMID 8672465 DOI: 10.1021/Bi952202R  0.327
1996 Yeaman C, Heinflink M, Falck-Pedersen E, Rodriguez-Boulan E, Gershengorn MC. Polarity of TRH receptors in transfected MDCK cells is independent of endocytosis signals and G protein coupling. The American Journal of Physiology. 270: C753-62. PMID 8638654 DOI: 10.1152/Ajpcell.1996.270.3.C753  0.504
1996 Gershengorn MC, Osman R. Molecular and cellular biology of thyrotropin-releasing hormone receptors. Physiological Reviews. 76: 175-91. PMID 8592728 DOI: 10.1152/Physrev.1996.76.1.175  0.389
1996 Wolff G, Mastrangeli A, Heinflink M, Falck-Pedersen E, Gershengorn MC, Crystal RG. Ectopic expression of thyrotropin releasing hormone (TRH) receptors in liver modulates organ function to regulate blood glucose by TRH Nature Genetics. 12: 274-279. PMID 8589718 DOI: 10.1038/Ng0396-274  0.371
1995 Heinflink M, Nussenzveig DR, Grimberg H, Lupu-Meiri M, Oron Y, Gershengorn MC. A constitutively active mutant thyrotropin-releasing hormone receptor is chronically down-regulated in pituitary cells: Evidence using chlordiazepoxide as a negative antagonist Molecular Endocrinology. 9: 1455-1460. PMID 8584022 DOI: 10.1210/Mend.9.11.8584022  0.469
1995 Matus-Leibovitch N, Nussenzveig DR, Gershengorn MC, Oron Y. Truncation of the thyrotropin-releasing hormone receptor carboxyl tail causes constitutive activity and leads to impaired responsiveness in Xenopus oocytes and AtT20 cells Journal of Biological Chemistry. 270: 1041-1047. PMID 7836357 DOI: 10.1074/Jbc.270.3.1041  0.432
1995 Ashworth R, Yu R, Nelson EJ, Dermer S, Gershengorn MC, Hinkle PM. Visualization of the thyrotropin-releasing hormone receptor and its ligand during endocytosis and recycling. Proceedings of the National Academy of Sciences of the United States of America. 92: 512-6. PMID 7831321 DOI: 10.1073/Pnas.92.2.512  0.365
1995 Perlman JH, Laakkonen L, Osman R, Gershengorn MC. Distinct roles for arginines in transmembrane helices 6 and 7 of the thyrotropin-releasing hormone receptor. Molecular Pharmacology. 47: 480-4. PMID 7700246  0.38
1995 Perlman JH, Wang W, Nussenzveig DR, Gershengorn MC. A disulfide bond between conserved extracellular cysteines in the thyrotropin-releasing hormone receptor is critical for binding Journal of Biological Chemistry. 270: 24682-24685. PMID 7559582 DOI: 10.1074/Jbc.270.42.24682  0.47
1995 Lipinsky D, Nussenzveig DR, Gershengorn MC, Oron Y. Desensitization of the response to thyrotropin-releasing hormone in Xenopus oocytes is an amplified process that precedes calcium mobilization PflüGers Archiv European Journal of Physiology. 429: 419-425. PMID 7539127 DOI: 10.1007/BF00374158  0.313
1995 Lipinsky D, Gershengorn MC, Oron Y. Contribution of response: Kinetics to the response pattern: Studies of responses to thyrotropin-releasing hormone in Xenopus oocytes Journal of Cellular Physiology. 162: 284-289. PMID 7529770 DOI: 10.1002/Jcp.1041620214  0.326
1995 Nussenzveig DR, Gershengorn MC. The structure and function of the thyrotropin-releasing hormone receptor Current Opinion in Endocrinology and Diabetes. 2: 437-448. DOI: 10.1097/00060793-199510000-00011  0.399
1994 Perlman JH, Thaw CN, Laakkonen L, Bowers CY, Osman R, Gershengorn MC. Hydrogen bonding interaction of thyrotropin-releasing hormone (TRH) with transmembrane tyrosine 106 of the TRH receptor. The Journal of Biological Chemistry. 269: 1610-3. PMID 8294406  0.341
1994 Falck-Pedersen E, Heinflink M, Alvira M, Nussenzveig DR, Gershengorn MC. Expression of thyrotropin-releasing hormone receptors by adenovirus-mediated gene transfer reveals that thyrotropin-releasing hormone desensitization is cell specific Molecular Pharmacology. 45: 684-689. PMID 8183247  0.346
1994 Gershengorn MC, Heinflink M, Nussenzveig DR, Hinkle PM, Falck-Pedersen E. Thyrotropin-releasing Hormone (TRH) Receptor Number Determines the Size of the TRH-responsive Phosphoinositide Pool: Demonstration using controlled expression of TRH receptors by adenovirus mediated gene transfer Journal of Biological Chemistry. 269: 6779-6783. PMID 8120038  0.318
1994 Perlman JH, Laakkonen L, Osman R, Gershengorn MC. A model of the thyrotropin-releasing hormone (TRH) receptor binding pocket. Evidence for a second direct interaction between transmembrane helix 3 and TRH. The Journal of Biological Chemistry. 269: 23383-6. PMID 8089099  0.334
1994 Heinflink M, Nussenzveig DR, Friedman AM, Gershengorn MC. Thyrotropin-releasing hormone receptor activation does not elevate intracellular cyclic adenosine 3',5'-monophosphate in cells expressing high levels of receptors Journal of Clinical Endocrinology and Metabolism. 79: 650-652. PMID 8045988 DOI: 10.1210/Jcem.79.2.8045988  0.47
1994 Nussenzveig DR, Thaw CN, Gershengorn MC. Inhibition of inositol phosphate second messenger formation by intracellular loop one of a human calcitonin receptor: Expression and mutational analysis of synthetic receptor genes Journal of Biological Chemistry. 269: 28123-28129. PMID 7961748  0.323
1994 Matus-Leibovitch N, Nussenzveig DR, Gershengorn MC, Oron Y. The hemispheric functional expression of the thyrotropin-releasing-hormone receptor is not determined by the receptors' physical distribution Biochemical Journal. 303: 129-134. PMID 7524480 DOI: 10.1042/Bj3030129  0.458
1993 Gershengorn MC. Thyrotropin-releasing hormone receptor: Cloning and regulation of its expression Recent Progress in Hormone Research. 48: 341-363. PMID 8382829 DOI: 10.1016/B978-0-12-571148-7.50016-6  0.482
1993 Nussenzveig DR, Heinflink M, Gershengorn MC. Agonist-stimulated internalization of the thyrotropin-releasing hormone receptor is dependent on two domains in the receptor carboxyl terminus Journal of Biological Chemistry. 268: 2389-2392. PMID 8381407  0.321
1993 Lipinsky D, Gershengorn MC, Oron Y. Latency in the inositol lipid transduction pathway: the role of cellular events in responses to thyrotropin-releasing hormone in Xenopus oocytes PflüGers Archiv European Journal of Physiology. 425: 140-149. PMID 8272369 DOI: 10.1007/Bf00374514  0.448
1993 Nussenzveig DR, Heinflink M, Gershengorn MC. Decreased levels of internalized thyrotropin-releasing hormone receptors after uncoupling from guanine nucleotide-binding protein and phospholipase-C Molecular Endocrinology. 7: 1105-1111. PMID 8247012 DOI: 10.1210/Mend.7.9.8247012  0.463
1993 Matus-Leibovitch N, Gershengorn MC, Oron Y. Differential effects of cytoskeletal agents on hemispheric functional expression of cell membrane receptors in xenopus oocytes Cellular and Molecular Neurobiology. 13: 625-637. PMID 8194080 DOI: 10.1007/Bf00711562  0.43
1993 Perlman JH, Laakkonen L, Thaw CN, Osman R, Gershengorn MC. Analysis of the role of transmembrane helix three of the thyrotropin-releasing hormone (TRH) receptor in directly binding TRH. Transactions of the Association of American Physicians. 106: 162-7. PMID 8036739  0.334
1992 Lipinsky D, Gershengorn MC, Oron Y. Gα11 and Gαq guaninine nucleotide regulatory proteins differentially modulate the response to thyrotropin-releasing hormone in Xenopus oocytes Febs Letters. 307: 237-240. PMID 1644177 DOI: 10.1016/0014-5793(92)80775-C  0.442
1992 Gershengorn MC, Purrello VS, Geras-Raaka E. Peripheral-type mitochondrial binding sites for benzodiazepines in gh3 pituitary cells Journal of Basic and Clinical Physiology and Pharmacology. 3: 59-70. PMID 1504063 DOI: 10.1515/Jbcpp.1992.3.1.59  0.375
1992 Perlman JH, Nussenzveig DR, Osman R, Gershengorn MC. Thyrotropin-releasing hormone binding to the mouse pituitary receptor does not involve ionic interactions. A model for neutral peptide binding to G protein-coupled receptors. The Journal of Biological Chemistry. 267: 24413-7. PMID 1332958  0.328
1992 Fujimoto J, Narayanan CS, Benjamin JE, Gershengorn MC. Posttranscriptional up-regulation of thyrotropin-releasing hormone (TRH) receptor messenger ribonucleic acid by TRH in COS-1 cells transfected with mouse pituitary TRH receptor complementary deoxyribonucleic acid. Endocrinology. 131: 1716-20. PMID 1327718 DOI: 10.1210/Endo.131.4.1327718  0.378
1992 Fujimoto J, Narayanan CS, Benjamin JE, Heinflink M, Gershengorn MC. Mechanism of regulation of thyrotropin-releasing hormone receptor messenger ribonucleic acid in stably transfected rat pituitary cells. Endocrinology. 130: 1879-84. PMID 1312428 DOI: 10.1210/Endo.130.4.1312428  0.374
1991 Cubitt AB, Thaw CN, Gershengorn MC. 5'-CMP stimulates phospholipase A-mediated hydrolysis of phosphatidylinositol in permeabilized pituitary GH3 cells Biochemical Journal. 278: 831-834. PMID 1898368 DOI: 10.1042/Bj2780831  0.375
1991 Gershengorn MC, Thaw CN. Regulation of thyrotropin-releasing hormone receptors is cell type specific: Comparison of endogenous pituitary receptors and receptors transfected into non-pituitary cells Endocrinology. 128: 1204-1206. PMID 1846583 DOI: 10.1210/Endo-128-2-1204  0.463
1991 Fujimoto J, Straub RE, Gershengorn MC. Thyrotropin-releasing hormone (TRH) and phorbol myristate acetate decrease TRH receptor messenger RNA in rat pituitary GH3 cells: evidence that protein kinase-C mediates the TRH effect. Molecular Endocrinology (Baltimore, Md.). 5: 1527-32. PMID 1723145 DOI: 10.1210/Mend-5-10-1527  0.428
1991 Fujimoto J, Gershengorn MC. Evidence for dual regulation by protein kinases A and C of thyrotropin-releasing hormone receptor mRNA in GH3 cells Endocrinology. 129: 3430-3432. PMID 1659532 DOI: 10.1210/Endo-129-6-3430  0.401
1991 Perlman JH, Gershengorn MC. Thyrotropin-releasing hormone stimulation of phosphoinositide hydrolysis desensitizes. Evidence against mediation by protein kinase C or calcium Endocrinology. 129: 2679-2686. PMID 1657582 DOI: 10.1210/Endo-129-5-2679  0.4
1990 Cubitt AB, Gershengorn MC. CMP activates reversal of phosphatidylinositol synthase and base exchange by distinct mechanisms in rat pituitary GH3 cells Biochemical Journal. 272: 813-816. PMID 2176479 DOI: 10.1042/Bj2720813  0.332
1990 Straub RE, Frech GC, Joho RH, Gershengorn MC. Expression cloning of a cDNA encoding the mouse pituitary thyrotropin-releasing hormone receptor. Proceedings of the National Academy of Sciences of the United States of America. 87: 9514-8. PMID 2175902 DOI: 10.1073/pnas.87.24.9514  0.39
1990 Cubitt AB, Geras-Raaka E, Gershengorn MC. Thyrotropin-releasing hormone receptor occupancy determines the fraction of the responsive pool of inositol lipids hydrolysed in rat pituitary tumour cells Biochemical Journal. 271: 331-336. PMID 2173558 DOI: 10.1042/Bj2710331  0.362
1990 Shapira H, Lupu-Meiri M, Gershengorn MC, Oron Y. Activation of two different receptors mobilizes calcium from distinct stores in Xenopus oocytes Biophysical Journal. 57: 1281-1285. PMID 2168222 DOI: 10.1016/S0006-3495(90)82646-1  0.375
1990 Brenner-Gati L, Trowbridge JM, Moucha CS, Gershengorn MC. Thyrotropin-induced elevation of 1,2-diacylglycerol and stimulation of growth of FRTL-5 cells are not dependent on inositol lipid hydrolysis. Endocrinology. 126: 1623-9. PMID 2155106 DOI: 10.1210/Endo-126-3-1623  0.338
1990 Winicov I, Cory RN, Gershengorn MC. Sphingosine interacts directly with the receptor complex to inhibit thyrotropin-releasing hormone binding Endocrinology. 126: 1668-1672. PMID 2106432 DOI: 10.1210/Endo-126-3-1668  0.446
1990 Gershengorn MC, Oron Y, Straub RE. Xenopus laevis oocytes injected with mammalian pituitary mRNA as a model system for study of thyrotropin-releasing hormone action. The Journal of Experimental Zoology. Supplement : Published Under Auspices of the American Society of Zoologists and the Division of Comparative Physiology and Biochemistry / the Wistar Institute of Anatomy and Biology. 4: 78-83. PMID 1974807 DOI: 10.1002/Jez.1402560414  0.367
1990 Pipili-Synetos E, Gershengorn MC, Jaffe EA. Expression of functional thrombin receptors in Xenopus oocytes injected with human endothelial cell mRNA Biochemical and Biophysical Research Communications. 171: 913-919. PMID 1699530 DOI: 10.1016/0006-291X(90)90770-N  0.398
1989 Brenner-Gati L, Berg KA, Gershengorn MC. Insulin-like growth factor-I potentiates thyrotropin stimulation of adenylyl cyclase in FRTL-5 cells Endocrinology. 125: 1315-1320. PMID 2547582 DOI: 10.1210/Endo-125-3-1315  0.353
1989 Winicov I, Gershengorn MC. Receptor density determines secretory response patterns mediated by inositol lipid-derived second messengers. Comparison of thyrotropin-releasing hormone and carbamylcholine actions in thyroid-stimulating hormone-secreting mouse pituitary tumor cells Journal of Biological Chemistry. 264: 9438-9443. PMID 2498332  0.372
1988 Brenner-Gati L, Berg KA, Gershengorn MC. Thyroid-stimulating hormone and insulin-like growth factor-1 synergize to elevate 1,2-diacylglycerol in rat thyroid cells. Stimulation of DNA synthesis via interaction between lipid and adenylyl cyclase signal transduction systems Journal of Clinical Investigation. 82: 1144-1148. PMID 2843569 DOI: 10.1172/Jci113672  0.332
1988 Gershengorn MC, Thaw CN, Geras-Raaka E. Benzodiazepines modulate voltage-sensitive calcium channels in GH3 pituitary cells at sites distinct from thyrotropin-releasing hormone receptors Endocrinology. 123: 541-544. PMID 2454810 DOI: 10.1210/Endo-123-1-541  0.387
1987 Rodriguez R, Imai A, Gershengorn MC. Phosphatidylinositol depletion in GH3 rat pituitary cells inhibits sustained responses to thyrotropin-releasing hormone. Reversal with myo-inositol Molecular Endocrinology. 1: 802-807. PMID 3155260 DOI: 10.1210/Mend-1-11-802  0.426
1987 Imai A, Gershengorn MC. Independent phosphatidylinositol synthesis in pituitary plasma membrane and endoplasmic reticulum Nature. 325: 726-728. PMID 3029593 DOI: 10.1038/325726A0  0.313
1987 Oron Y, Gillo B, Straub RE, Gershengorn MC. Mechanism of membrane electrical response to thyrotropin-releasing hormone in Xenopus oocytes injected with GH3 pituitary cell messenger ribonucleic acid. Molecular Endocrinology (Baltimore, Md.). 1: 918-25. PMID 2856406 DOI: 10.1210/Mend-1-12-918  0.375
1987 Oron Y, Straub RE, Traktman P, Gershengorn MC. Decreased TRH receptor mRNA activity precedes homologous downregulation: assay in oocytes. Science (New York, N.Y.). 238: 1406-8. PMID 2825350 DOI: 10.1126/Science.2825350  0.331
1987 Kolesnick RN, Gershengorn MC. Thyrotropin-Releasing Hormone: Role of Polyphosphoinositides in Stimulation of Prolactin Secretion Current Topics in Membranes and Transport. 31: 115-138. DOI: 10.1016/S0070-2161(08)60059-3  0.401
1986 Kolesnick RN, Gershengorn MC. Thyrotropin-releasing hormone stimulation of prolactin secretion is coordinately but not synergistically regulated by an elevation of cytoplasmic calcium and 1,2-diacylglycerol Endocrinology. 119: 2461-2466. PMID 3096691 DOI: 10.1210/Endo-119-6-2461  0.359
1986 Hinkle PM, Hewlett EL, Gershengorn MC. Thyroliberin action in pituitary cells is not inhibited by pertussis toxin Biochemical Journal. 237: 181-186. PMID 3026309 DOI: 10.1042/Bj2370181  0.474
1986 Gershengorn MC, Paul ME. Evidence for tight coupling of receptor occupancy by thyrotropin-releasing hormone to phospolipase C-mediated phosphoinositide hydrolysis in rat pituitary cells: Use of chlordiazepoxide as a competitive antagonist Endocrinology. 119: 833-839. PMID 3015558 DOI: 10.1210/Endo-119-2-833  0.491
1986 Brenner-Gati L, Gershengorn MC. Effects of thyrotropin-releasing hormone on phosphoinositides and cytoplasmic free calcium in thyrotropic pituitary cells Endocrinology. 118: 163-169. PMID 3000732 DOI: 10.1210/Endo-118-1-163  0.37
1985 Gershengorn MC. Thyrotropin-releasing hormone action: mechanism of calcium-mediated stimulation of prolactin secretion Recent Progress in Hormone Research. 41: 607-653. PMID 2996093 DOI: 10.1016/B978-0-12-571141-8.50019-6  0.409
1985 Imai A, Gershengorn MC. Evidence for tight coupling of thyrotropin-releasing hormone receptors to stimulated inositol trisphosphate formation in rat pituitary cells Journal of Biological Chemistry. 260: 10536-10540. PMID 2993279  0.344
1985 Kolesnick RN, Gershengorn MC. Thyrotropin-releasing hormone and the pituitary. New insights into the mechanism of stimulated secretion and clinical usage The American Journal of Medicine. 79: 729-739. PMID 2416218 DOI: 10.1016/0002-9343(85)90524-8  0.348
1984 Kolesnick RN, Musacchio I, Thaw C, Gershengorn MC. Thyrotropin (TSH)-releasing hormone decreases phosphatidylinositol and increases unesterified arachidonic acid in thyrotropic cells: Possible early events in stimulation of TSH secretion Endocrinology. 114: 671-676. PMID 6418535 DOI: 10.1210/Endo-114-2-671  0.345
1984 Thaw CN, Raaka EG, Gershengorn MC. Evidence that cobalt ion inhibition of prolactin secretion occurs at an intracellular locus American Journal of Physiology - Cell Physiology. 16. DOI: 10.1152/Ajpcell.1984.247.3.C150  0.365
1981 Gershengorn MC, Hoffstein ST, Rebecchi MJ, Geras E, Rubin BG. Thyrotropin-releasing hormone stimulation of prolactin release from clonal rat pituitary cells. Evidence for action independent of extracellular calcium Journal of Clinical Investigation. 67: 1769-1776. PMID 6787084 DOI: 10.1172/Jci110216  0.325
1980 Gershengorn MC, Arevalo CO, Geras E, Rebecchi MJ. Thyrotropin-releasing hormone stimulation of adrenocorticotropin production by mouse pituitary tumor cells in culture. Possible model for anomalous release of adrenocorticotropin by thyrotropin-releasing hormone in some patients with Cushing's disease and Nelson's syndrome Journal of Clinical Investigation. 65: 1294-1300. PMID 6251109 DOI: 10.1172/Jci109792  0.419
1980 Peck V, Gershengorn MC. Differential regulation of thyrotropin releasing hormone receptors in neoplastic rodent mammotropic, adrenocorticotropic and thyrotropic pituitary cells in culture Journal of Clinical Endocrinology and Metabolism. 50: 1144-1146. PMID 6246145  0.359
1979 Gershengorn MC, Marcus-Samuels BE, Geras E. Estrogens increase the number of thyrotropin-releasing hormone receptors on mammotropic cells in culture Endocrinology. 105: 171-176. PMID 221199  0.337
1979 Gershengorn MC, Geras E, Marcus-Samuels BE. Discordant effects of estradiol on thyrotropin releasing hormone (TRH) receptors in mammotropic and thyrotropic cells Clinical Research. 27.  0.343
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