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Roger L. Kaspar - Publications

Affiliations: 
Brigham Young University, Provo, UT, United States 
Area:
Biochemistry, Immunology, Molecular Biology
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43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Kaspar RL, Hickerson RP, González-González E, Flores MA, Speaker TP, Rogers FA, Milstone LM, Contag CH. Imaging Functional Nucleic Acid Delivery to Skin. Methods in Molecular Biology (Clifton, N.J.). 1372: 1-24. PMID 26530911 DOI: 10.1007/978-1-4939-3148-4_1  0.333
2015 Hickerson RP, Speaker TJ, Lara MF, González-González E, Flores MA, Contag CH, Kaspar RL. Non-Invasive Intravital Imaging of siRNA-Mediated Mutant Keratin Gene Repression in Skin. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. PMID 26169581 DOI: 10.1007/S11307-015-0875-Z  0.401
2015 Kanada M, Bachmann MH, Hardy JW, Frimannson DO, Bronsart L, Wang A, Sylvester MD, Schmidt TL, Kaspar RL, Butte MJ, Matin AC, Contag CH. Differential fates of biomolecules delivered to target cells via extracellular vesicles. Proceedings of the National Academy of Sciences of the United States of America. 112: E1433-42. PMID 25713383 DOI: 10.1073/Pnas.1418401112  0.332
2015 Cao YA, Hickerson RP, Seegmiller BL, Grapov D, Gross MM, Bessette MR, Phinney BS, Flores MA, Speaker TJ, Vermeulen A, Bravo AA, Bruckner AL, Milstone LM, Schwartz ME, Rice RH, ... Kaspar RL, et al. Gene expression profiling in pachyonychia congenita skin. Journal of Dermatological Science. 77: 156-65. PMID 25656049 DOI: 10.1016/J.Jdermsci.2015.01.001  0.315
2013 Lessard JC, Piña-Paz S, Rotty JD, Hickerson RP, Kaspar RL, Balmain A, Coulombe PA. Keratin 16 regulates innate immunity in response to epidermal barrier breach Proceedings of the National Academy of Sciences of the United States of America. 110: 19537-19542. PMID 24218583 DOI: 10.1073/Pnas.1309576110  0.326
2013 Hickerson RP, Wey WC, Rimm DL, Speaker T, Suh S, Flores MA, Gonzalez-Gonzalez E, Leake D, Contag CH, Kaspar RL. Gene Silencing in Skin After Deposition of Self-Delivery siRNA With a Motorized Microneedle Array Device. Molecular Therapy. Nucleic Acids. 2: e129. PMID 24150576 DOI: 10.1038/Mtna.2013.56  0.354
2013 Chong RH, Gonzalez-Gonzalez E, Lara MF, Speaker TJ, Contag CH, Kaspar RL, Coulman SA, Hargest R, Birchall JC. Gene silencing following siRNA delivery to skin via coated steel microneedles: In vitro and in vivo proof-of-concept. Journal of Controlled Release : Official Journal of the Controlled Release Society. 166: 211-9. PMID 23313112 DOI: 10.1016/J.Jconrel.2012.12.030  0.37
2012 Hickerson RP, Gonzalez-Gonzalez E, Vlassov AV, Li M, Lara MF, Contag CH, Kaspar RL. Intravital fluorescence imaging of small interfering RNA-mediated gene repression in a dual reporter melanoma xenograft model. Nucleic Acid Therapeutics. 22: 438-43. PMID 23098239 DOI: 10.1089/Nat.2012.0364  0.383
2012 Geihe EI, Cooley CB, Simon JR, Kiesewetter MK, Edward JA, Hickerson RP, Kaspar RL, Hedrick JL, Waymouth RM, Wender PA. Designed guanidinium-rich amphipathic oligocarbonate molecular transporters complex, deliver and release siRNA in cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 13171-6. PMID 22847412 DOI: 10.1073/Pnas.1211361109  0.302
2012 Lara MF, González-González E, Speaker TJ, Hickerson RP, Leake D, Milstone LM, Contag CH, Kaspar RL. Inhibition of CD44 gene expression in human skin models, using self-delivery short interfering RNA administered by dissolvable microneedle arrays. Human Gene Therapy. 23: 816-23. PMID 22480249 DOI: 10.1089/Hum.2011.211  0.395
2012 Leslie Pedrioli DM, Fu DJ, Gonzalez-Gonzalez E, Contag CH, Kaspar RL, Smith FJ, McLean WH. Generic and personalized RNAi-based therapeutics for a dominant-negative epidermal fragility disorder. The Journal of Investigative Dermatology. 132: 1627-35. PMID 22402445 DOI: 10.1038/Jid.2012.28  0.389
2011 González-González E, Kim YC, Speaker TJ, Hickerson RP, Spitler R, Birchall JC, Lara MF, Hu RH, Liang Y, Kirkiles-Smith N, Prausnitz MR, Milstone LM, Contag CH, Kaspar RL. Visualization of plasmid delivery to keratinocytes in mouse and human epidermis. Scientific Reports. 1: 158. PMID 22355673 DOI: 10.1038/Srep00158  0.346
2011 Hickerson RP, Flores MA, Leake D, Lara MF, Contag CH, Leachman SA, Kaspar RL. Use of self-delivery siRNAs to inhibit gene expression in an organotypic pachyonychia congenita model. The Journal of Investigative Dermatology. 131: 1037-44. PMID 21248764 DOI: 10.1038/Jid.2010.426  0.421
2011 Ra H, Piyawattanametha W, Gonzalez-Gonzalez E, Mandella MJ, Kino GS, Solgaard O, Leake D, Kaspar RL, Oro A, Contag CH. In vivo imaging of human and mouse skin with a handheld dual-axis confocal fluorescence microscope. The Journal of Investigative Dermatology. 131: 1061-6. PMID 21191407 DOI: 10.1038/Jid.2010.401  0.358
2011 Hickerson RP, Leachman SA, Pho LN, Gonzalez-Gonzalez E, Smith FJ, McLean WH, Contag CH, Leake D, Milstone LM, Kaspar RL. Development of quantitative molecular clinical end points for siRNA clinical trials. The Journal of Investigative Dermatology. 131: 1029-36. PMID 21191405 DOI: 10.1038/Jid.2010.372  0.467
2011 García M, Larcher F, Hickerson RP, Baselga E, Leachman SA, Kaspar RL, Del Rio M. Development of skin-humanized mouse models of pachyonychia congenita. The Journal of Investigative Dermatology. 131: 1053-60. PMID 21150925 DOI: 10.1038/Jid.2010.353  0.363
2010 Ra H, Gonzalez-Gonzalez E, Smith BR, Gambhir SS, Kino GS, Solgaard O, Kaspar RL, Contag CH. Assessing delivery and quantifying efficacy of small interfering ribonucleic acid therapeutics in the skin using a dual-axis confocal microscope. Journal of Biomedical Optics. 15: 036027. PMID 20615029 DOI: 10.1117/1.3432627  0.351
2010 Gonzalez-Gonzalez E, Speaker TJ, Hickerson RP, Spitler R, Flores MA, Leake D, Contag CH, Kaspar RL. Silencing of reporter gene expression in skin using siRNAs and expression of plasmid DNA delivered by a soluble protrusion array device (PAD). Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 1667-74. PMID 20571543 DOI: 10.1038/Mt.2010.126  0.394
2010 González-González E, Ra H, Spitler R, Hickerson RP, Contag CH, Kaspar RL. Increased interstitial pressure improves nucleic acid delivery to skin enabling a comparative analysis of constitutive promoters. Gene Therapy. 17: 1270-8. PMID 20463756 DOI: 10.1038/Gt.2010.74  0.339
2010 Leachman SA, Hickerson RP, Schwartz ME, Bullough EE, Hutcherson SL, Boucher KM, Hansen CD, Eliason MJ, Srivatsa GS, Kornbrust DJ, Smith FJ, McLean WI, Milstone LM, Kaspar RL. First-in-human mutation-targeted siRNA phase Ib trial of an inherited skin disorder. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 442-6. PMID 19935778 DOI: 10.1038/Mt.2009.273  0.406
2009 Kaspar RL, McLean WH, Schwartz ME. Achieving successful delivery of nucleic acids to skin: 6th Annual Meeting of the International Pachyonychia Congenita Consortium. The Journal of Investigative Dermatology. 129: 2085-7. PMID 19809420 DOI: 10.1038/Jid.2009.220  0.357
2009 Hickerson RP, Leake D, Pho LN, Leachman SA, Kaspar RL. Rapamycin selectively inhibits expression of an inducible keratin (K6a) in human keratinocytes and improves symptoms in pachyonychia congenita patients. Journal of Dermatological Science. 56: 82-8. PMID 19699613 DOI: 10.1016/J.Jdermsci.2009.07.008  0.417
2009 Gonzalez-Gonzalez E, Ra H, Hickerson RP, Wang Q, Piyawattanametha W, Mandella MJ, Kino GS, Leake D, Avilion AA, Solgaard O, Doyle TC, Contag CH, Kaspar RL. siRNA silencing of keratinocyte-specific GFP expression in a transgenic mouse skin model. Gene Therapy. 16: 963-72. PMID 19474811 DOI: 10.1038/Gt.2009.62  0.403
2008 Dallas A, Balatskaya SV, Kuo TC, Ilves H, Vlassov AV, Kaspar RL, Kisich KO, Kazakov SA, Johnston BH. Hairpin ribozyme-antisense RNA constructs can act as molecular Lassos. Nucleic Acids Research. 36: 6752-66. PMID 18953032 DOI: 10.1093/Nar/Gkn637  0.366
2008 Hickerson RP, Vlassov AV, Wang Q, Leake D, Ilves H, Gonzalez-Gonzalez E, Contag CH, Johnston BH, Kaspar RL. Stability study of unmodified siRNA and relevance to clinical use. Oligonucleotides. 18: 345-54. PMID 18844576 DOI: 10.1089/Oli.2008.0149  0.329
2008 Leachman SA, Hickerson RP, Hull PR, Smith FJ, Milstone LM, Lane EB, Bale SJ, Roop DR, McLean WH, Kaspar RL. Therapeutic siRNAs for dominant genetic skin disorders including pachyonychia congenita. Journal of Dermatological Science. 51: 151-7. PMID 18495438 DOI: 10.1016/J.Jdermsci.2008.04.003  0.347
2008 Hickerson RP, Smith FJ, Reeves RE, Contag CH, Leake D, Leachman SA, Milstone LM, McLean WH, Kaspar RL. Single-nucleotide-specific siRNA targeting in a dominant-negative skin model. The Journal of Investigative Dermatology. 128: 594-605. PMID 17914454 DOI: 10.1038/Sj.Jid.5701060  0.411
2008 Smith FJ, Hickerson RP, Sayers JM, Reeves RE, Contag CH, Leake D, Kaspar RL, McLean WH. Development of therapeutic siRNAs for pachyonychia congenita. The Journal of Investigative Dermatology. 128: 50-8. PMID 17762855 DOI: 10.1038/Sj.Jid.5701040  0.425
2007 Vlassov AV, Korba B, Farrar K, Mukerjee S, Seyhan AA, Ilves H, Kaspar RL, Leake D, Kazakov SA, Johnston BH. shRNAs targeting hepatitis C: effects of sequence and structural features, and comparision with siRNA. Oligonucleotides. 17: 223-36. PMID 17638526 DOI: 10.1089/Oli.2006.0069  0.345
2007 Kakegawa T, Ohuchi N, Hayakawa A, Hirata S, Matsuda M, Kogure K, Kobayashi H, Inoue A, Kaspar RL. Identification of AUF1 as a rapamycin-responsive binding protein to the 5'-terminal oligopyrimidine element of mRNAs. Archives of Biochemistry and Biophysics. 465: 274-81. PMID 17603996 DOI: 10.1016/J.Abb.2007.06.001  0.369
2007 Wang Q, Ilves H, Chu P, Contag CH, Leake D, Johnston BH, Kaspar RL. Delivery and inhibition of reporter genes by small interfering RNAs in a mouse skin model. The Journal of Investigative Dermatology. 127: 2577-84. PMID 17522708 DOI: 10.1038/Sj.Jid.5700891  0.41
2006 Hickerson RP, Smith FJ, McLean WH, Landthaler M, Leube RE, Kaspar RL. SiRNA-mediated selective inhibition of mutant keratin mRNAs responsible for the skin disorder pachyonychia congenita. Annals of the New York Academy of Sciences. 1082: 56-61. PMID 17145926 DOI: 10.1196/Annals.1348.059  0.423
2006 Ilves H, Kaspar RL, Wang Q, Seyhan AA, Vlassov AV, Contag CH, Leake D, Johnston BH. Inhibition of hepatitis C IRES-mediated gene expression by small hairpin RNAs in human hepatocytes and mice. Annals of the New York Academy of Sciences. 1082: 52-5. PMID 17145925 DOI: 10.1196/Annals.1348.060  0.339
2005 Wang Q, Contag CH, Ilves H, Johnston BH, Kaspar RL. Small hairpin RNAs efficiently inhibit hepatitis C IRES-Mediated gene expression in human tissue culture cells and a mouse model Molecular Therapy. 12: 562-568. PMID 15953767 DOI: 10.1016/J.Ymthe.2005.04.014  0.315
2005 Seyhan AA, Vlassov AV, Ilves H, Egry L, Kaspar RL, Kazakov SA, Johnston BH. Complete, gene-specific siRNA libraries: production and expression in mammalian cells. Rna (New York, N.Y.). 11: 837-46. PMID 15840823 DOI: 10.1261/Rna.7285805  0.351
2003 Zhu J, Spencer ED, Kaspar RL. Differential translation of TOP mRNAs in rapamycin-treated human B lymphocytes. Biochimica Et Biophysica Acta. 1628: 50-5. PMID 12850272 DOI: 10.1016/S0167-4781(03)00117-9  0.584
2002 Kakegawa T, Ito M, Hayakawa A, Matsuda M, Tamura S, Saito H, Kaspar RL, Kobayashi H. Rapamycin induces binding activity to the terminal oligopyrimidine tract of ribosomal protein mRNA in rats. Archives of Biochemistry and Biophysics. 402: 77-83. PMID 12051685 DOI: 10.1016/S0003-9861(02)00070-X  0.421
2001 Zhu J, Hayakawa A, Kakegawa T, Kaspar RL. Binding of the La autoantigen to the 5' untranslated region of a chimeric human translation elongation factor 1A reporter mRNA inhibits translation in vitro. Biochimica Et Biophysica Acta. 1521: 19-29. PMID 11690632 DOI: 10.1016/S0167-4781(01)00277-9  0.477
2000 Stuart JJ, Egry LA, Wong GH, Kaspar RL. The 3' UTR of human MnSOD mRNA hybridizes to a small cytoplasmic RNA and inhibits gene expression Biochemical and Biophysical Research Communications. 274: 641-648. PMID 10924331 DOI: 10.1006/Bbrc.2000.3189  0.458
1998 Nashimoto M, Geary S, Tamura M, Kaspar R. RNA heptamers that direct RNA cleavage by mammalian tRNA 3' processing endoribonuclease. Nucleic Acids Research. 26: 2565-72. PMID 9592138 DOI: 10.1093/Nar/26.11.2565  0.338
1996 Rousseau D, Kaspar R, Rosenwald I, Gehrke L, Sonenberg N. Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E Proceedings of the National Academy of Sciences of the United States of America. 93: 1065-1070. PMID 8577715 DOI: 10.1073/Pnas.93.3.1065  0.378
1995 Rosenwald IB, Kaspar R, Rousseau D, Gehrke L, Leboulch P, Chen JJ, Schmidt EV, Sonenberg N, London IM. Eukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and post-transcriptional levels. The Journal of Biological Chemistry. 270: 21176-80. PMID 7673150 DOI: 10.1074/Jbc.270.36.21176  0.332
1994 Gehrke L, Hann LE, Kaspar RL. Chapter 25. Translational Control of Gene Expression Annual Reports in Medicinal Chemistry. 29: 245-254. DOI: 10.1016/S0065-7743(08)60738-1  0.323
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