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Gerald F. Joyce - Publications

Affiliations: 
Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
Directed Evolution of RNA and DNA Enzymes
Website:
http://www.scripps.edu/mb/joyce/joyce.html
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128 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Papastavrou N, Horning DP, Joyce GF. RNA-catalyzed evolution of catalytic RNA. Proceedings of the National Academy of Sciences of the United States of America. 121: e2321592121. PMID 38437533 DOI: 10.1073/pnas.2321592121  0.525
2024 Bare GAL, Joyce GF. Correction to "Cross-Chiral, RNA-Catalyzed Exponential Amplification of RNA". Journal of the American Chemical Society. PMID 38266496 DOI: 10.1021/jacs.3c14485  0.466
2023 Kakoti A, Joyce GF. RNA Polymerase Ribozyme That Recognizes the Template-Primer Complex through Tertiary Interactions. Biochemistry. PMID 37256719 DOI: 10.1021/acs.biochem.3c00091  0.84
2022 Menichelli E, Lam BJ, Wang Y, Wang VS, Shaffer J, Tjhung KF, Bursulaya B, Nguyen TN, Vo T, Alper PB, McAllister CS, Jones DH, Spraggon G, Michellys PY, Joslin J, ... Joyce GF, et al. Discovery of small molecules that target a tertiary-structured RNA. Proceedings of the National Academy of Sciences of the United States of America. 119: e2213117119. PMID 36413497 DOI: 10.1073/pnas.2213117119  0.322
2021 Bare GAL, Joyce GF. Cross-Chiral, RNA-Catalyzed Exponential Amplification of RNA. Journal of the American Chemical Society. 143: 19160-19166. PMID 34731573 DOI: 10.1021/jacs.1c09233  0.509
2021 Portillo X, Huang YT, Breaker RR, Horning DP, Joyce GF. Witnessing the structural evolution of an RNA enzyme. Elife. 10. PMID 34498588 DOI: 10.7554/eLife.71557  0.635
2020 Tjhung KF, Sczepanski JT, Murtfeldt ER, Joyce GF. RNA-Catalyzed Cross-Chiral Polymerization of RNA. Journal of the American Chemical Society. 142: 15331-15339. PMID 32805113 DOI: 10.1021/Jacs.0C05635  0.789
2020 Salditt A, Keil LMR, Horning DP, Mast CB, Joyce GF, Braun D. Thermal Habitat for RNA Amplification and Accumulation. Physical Review Letters. 125: 048104. PMID 32794805 DOI: 10.1103/Physrevlett.125.048104  0.565
2020 Tjhung KF, Shokhirev MN, Horning DP, Joyce GF. An RNA polymerase ribozyme that synthesizes its own ancestor. Proceedings of the National Academy of Sciences of the United States of America. PMID 31988127 DOI: 10.1073/Pnas.1914282117  0.599
2019 Horning DP, Bala S, Chaput JC, Joyce GF. RNA-Catalyzed Polymerization of Deoxyribose, Threose, and Arabinose Nucleic Acids. Acs Synthetic Biology. PMID 31042360 DOI: 10.1021/Acssynbio.9B00044  0.559
2019 Pressman AD, Liu Z, Janzen E, Blanco C, Müller UF, Joyce GF, Pascal R, Chen IA. Mapping a systematic ribozyme fitness landscape reveals a frustrated evolutionary network for self-aminoacylating RNA. Journal of the American Chemical Society. PMID 30912655 DOI: 10.1021/Jacs.8B13298  0.515
2018 Joyce GF, Szostak JW. Protocells and RNA Self-Replication. Cold Spring Harbor Perspectives in Biology. 10. PMID 30181195 DOI: 10.1101/Cshperspect.A034801  0.584
2018 Samanta B, Horning DP, Joyce GF. 3'-End labeling of nucleic acids by a polymerase ribozyme. Nucleic Acids Research. PMID 29901762 DOI: 10.1093/Nar/Gky513  0.5
2017 Joyce GF, Samanta B. A reverse transcriptase ribozyme. Elife. 6. PMID 28949294 DOI: 10.7554/Elife.31153  0.577
2016 Olea C, Joyce GF. Real-Time Detection of a Self-Replicating RNA Enzyme. Molecules (Basel, Switzerland). 21. PMID 27706059 DOI: 10.3390/Molecules21101310  0.493
2016 Horning DP, Joyce GF. Amplification of RNA by an RNA polymerase ribozyme. Proceedings of the National Academy of Sciences of the United States of America. PMID 27528667 DOI: 10.1073/Pnas.1610103113  0.587
2015 Sczepanski JT, Joyce GF. Specific Inhibition of MicroRNA Processing Using L-RNA Aptamers. Journal of the American Chemical Society. PMID 26652064 DOI: 10.1021/Jacs.5B06696  0.681
2015 Olea C, Weidmann J, Dawson PE, Joyce GF. An L-RNA Aptamer that Binds and Inhibits RNase. Chemistry & Biology. 22: 1437-41. PMID 26590636 DOI: 10.1016/J.Chembiol.2015.09.017  0.504
2015 Olea C, Joyce GF. Ligand-dependent exponential amplification of self-replicating RNA enzymes. Methods in Enzymology. 550: 23-39. PMID 25605379 DOI: 10.1016/Bs.Mie.2014.10.030  0.482
2014 Sczepanski JT, Joyce GF. A cross-chiral RNA polymerase ribozyme. Nature. 515: 440-2. PMID 25363769 DOI: 10.1038/Nature13900  0.795
2014 Breaker RR, Joyce GF. The expanding view of RNA and DNA function. Chemistry & Biology. 21: 1059-65. PMID 25237854 DOI: 10.1016/J.Chembiol.2014.07.008  0.619
2014 Petrie KL, Joyce GF. Limits of neutral drift: lessons from the in vitro evolution of two ribozymes. Journal of Molecular Evolution. 79: 75-90. PMID 25155818 DOI: 10.1007/S00239-014-9642-Z  0.357
2014 Robertson MP, Joyce GF. Highly efficient self-replicating RNA enzymes. Chemistry & Biology. 21: 238-45. PMID 24388759 DOI: 10.1016/J.Chembiol.2013.12.004  0.643
2013 Sczepanski JT, Joyce GF. Binding of a structured D-RNA molecule by an L-RNA aptamer. Journal of the American Chemical Society. 135: 13290-3. PMID 23977945 DOI: 10.1021/Ja406634G  0.749
2013 Ferretti AC, Joyce GF. Kinetic properties of an RNA enzyme that undergoes self-sustained exponential amplification. Biochemistry. 52: 1227-35. PMID 23384307 DOI: 10.1021/Bi301646N  0.487
2013 Dunitz JD, Joyce GF. Leslie Eleazer Orgel. 12 January 1927 — 27 October 2007 Biographical Memoirs of Fellows of the Royal Society. 59: 277-289. DOI: 10.1098/Rsbm.2013.0002  0.417
2012 Sczepanski JT, Joyce GF. Synthetic evolving systems that implement a user-specified genetic code of arbitrary design. Chemistry & Biology. 19: 1324-32. PMID 23102225 DOI: 10.1016/J.Chembiol.2012.08.017  0.716
2012 Olea C, Horning DP, Joyce GF. Ligand-dependent exponential amplification of a self-replicating L-RNA enzyme. Journal of the American Chemical Society. 134: 8050-3. PMID 22551009 DOI: 10.1021/Ja302197X  0.49
2012 Joyce GF. Evolution. Toward an alternative biology. Science (New York, N.Y.). 336: 307-8. PMID 22517850 DOI: 10.1126/Science.1221724  0.353
2012 Robertson MP, Joyce GF. The origins of the RNA world. Cold Spring Harbor Perspectives in Biology. 4. PMID 20739415 DOI: 10.1101/Cshperspect.A003608  0.724
2011 Lam BJ, Joyce GF. An isothermal system that couples ligand-dependent catalysis to ligand-independent exponential amplification. Journal of the American Chemical Society. 133: 3191-7. PMID 21322594 DOI: 10.1021/Ja111136D  0.425
2010 Petrie KL, Joyce GF. Deep sequencing analysis of mutations resulting from the incorporation of dNTP analogs. Nucleic Acids Research. 38: 8095-104. PMID 20693528 DOI: 10.1093/Nar/Gkq685  0.405
2010 Paegel BM, Joyce GF. Microfluidic compartmentalized directed evolution. Chemistry & Biology. 17: 717-24. PMID 20659684 DOI: 10.1016/J.Chembiol.2010.05.021  0.736
2010 Joyce GF, Dai X, De Mesmaeker A. Amide cleavage by a ribozyme: correction. Science (New York, N.Y.). 272: 18c-9c. PMID 17789965 DOI: 10.1126/Science.272.5258.18C  0.348
2009 Joyce GF. Evolution in an RNA world. Cold Spring Harbor Symposia On Quantitative Biology. 74: 17-23. PMID 19667013 DOI: 10.1101/Sqb.2009.74.004  0.603
2009 Voytek SB, Joyce GF. Niche partitioning in the coevolution of 2 distinct RNA enzymes. Proceedings of the National Academy of Sciences of the United States of America. 106: 7780-5. PMID 19416904 DOI: 10.1073/Pnas.0903397106  0.466
2009 Lam BJ, Joyce GF. Autocatalytic aptazymes enable ligand-dependent exponential amplification of RNA. Nature Biotechnology. 27: 288-92. PMID 19234448 DOI: 10.1038/Nbt.1528  0.542
2009 Lincoln TA, Joyce GF. Self-sustained replication of an RNA enzyme. Science (New York, N.Y.). 323: 1229-32. PMID 19131595 DOI: 10.1126/Science.1167856  0.563
2008 Paegel BM, Joyce GF. Darwinian evolution on a chip. Plos Biology. 6: e85. PMID 18399721 DOI: 10.1371/Journal.Pbio.0060085  0.736
2008 Paegel BM, Joyce GF. Microfluidic darwinian evolution 12th International Conference On Miniaturized Systems For Chemistry and Life Sciences - the Proceedings of Microtas 2008 Conference. 637-639.  0.626
2007 Voytek SB, Joyce GF. Emergence of a fast-reacting ribozyme that is capable of undergoing continuous evolution. Proceedings of the National Academy of Sciences of the United States of America. 104: 15288-93. PMID 17878292 DOI: 10.1073/Pnas.0707490104  0.569
2007 Joyce GF. Forty years of in vitro evolution. Angewandte Chemie (International Ed. in English). 46: 6420-36. PMID 17634987 DOI: 10.1002/Anie.200701369  0.487
2007 Joyce GF. Structural biology. A glimpse of biology's first enzyme. Science (New York, N.Y.). 315: 1507-8. PMID 17363651 DOI: 10.1126/Science.1140736  0.508
2007 Joyce G. Vierzig Jahre Evolution im Reagenzglas Angewandte Chemie. 119: 6540-6557. DOI: 10.1002/Ange.200701369  0.509
2006 Paegel BM, Grover WH, Skelley AM, Mathies RA, Joyce GF. Microfluidic serial dilution circuit. Analytical Chemistry. 78: 7522-7. PMID 17073422 DOI: 10.1021/Ac0608265  0.707
2006 Paul N, Springsteen G, Joyce GF. Conversion of a ribozyme to a deoxyribozyme through in vitro evolution. Chemistry & Biology. 13: 329-38. PMID 16638538 DOI: 10.1016/J.Chembiol.2006.01.007  0.815
2006 Joyce GF, Orgel LE. 2 Progress toward Understanding the Origin of the RNA World Cold Spring Harbor Monograph Archive. 43: 23-56. DOI: 10.1101/087969739.43.23  0.691
2005 Oberhuber M, Joyce GF. A DNA-templated aldol reaction as a model for the formation of pentose sugars in the RNA world. Angewandte Chemie (International Ed. in English). 44: 7580-3. PMID 16240312 DOI: 10.1002/Anie.200503387  0.503
2005 Johns GC, Joyce GF. The promise and peril of continuous in vitro evolution. Journal of Molecular Evolution. 61: 253-63. PMID 15999246 DOI: 10.1007/S00239-004-0307-1  0.326
2005 Paegel BM, Joyce GF. Microfluidic serial transfer circuit: Automated evolution of RNA catalysts Micro Total Analysis Systems - Proceedings of Microtas 2005 Conference: 9th International Conference On Miniaturized Systems For Chemistry and Life Sciences. 1: 28-30.  0.718
2004 Kim DE, Joyce GF. Cross-catalytic replication of an RNA ligase ribozyme. Chemistry & Biology. 11: 1505-12. PMID 15556001 DOI: 10.1016/J.Chembiol.2004.08.021  0.558
2004 Springsteen G, Joyce GF. Selective derivatization and sequestration of ribose from a prebiotic mix. Journal of the American Chemical Society. 126: 9578-83. PMID 15291561 DOI: 10.1021/Ja0483692  0.797
2004 Joyce GF. Directed evolution of nucleic acid enzymes. Annual Review of Biochemistry. 73: 791-836. PMID 15189159 DOI: 10.1146/Annurev.Biochem.73.011303.073717  0.565
2004 Shih WM, Quispe JD, Joyce GF. A 1.7-kilobase single-stranded DNA that folds into a nanoscale octahedron. Nature. 427: 618-21. PMID 14961116 DOI: 10.1038/Nature02307  0.62
2003 Kühne H, Joyce GF. Continuous in vitro evolution of ribozymes that operate under conditions of extreme pH. Journal of Molecular Evolution. 57: 292-8. PMID 14629039 DOI: 10.1007/S00239-003-2480-Z  0.317
2003 Kumar RM, Joyce GF. A modular, bifunctional RNA that integrates itself into a target RNA. Proceedings of the National Academy of Sciences of the United States of America. 100: 9738-43. PMID 12913125 DOI: 10.1073/Pnas.1334190100  0.704
2003 Kuhns ST, Joyce GF. Perfectly complementary nucleic acid enzymes. Journal of Molecular Evolution. 56: 711-7. PMID 12911034 DOI: 10.1007/S00239-002-2445-7  0.421
2003 McGinness KE, Joyce GF. In search of an RNA replicase ribozyme. Chemistry & Biology. 10: 5-14. PMID 12573693 DOI: 10.1016/S1074-5521(03)00003-6  0.818
2002 Reader JS, Joyce GF. A ribozyme composed of only two different nucleotides. Nature. 420: 841-4. PMID 12490955 DOI: 10.1038/Nature01185  0.478
2002 Paul N, Joyce GF. A self-replicating ligase ribozyme. Proceedings of the National Academy of Sciences of the United States of America. 99: 12733-40. PMID 12239349 DOI: 10.1073/Pnas.202471099  0.458
2002 Joyce GF. The antiquity of RNA-based evolution. Nature. 418: 214-21. PMID 12110897 DOI: 10.1038/418214A  0.569
2002 McGinness KE, Wright MC, Joyce GF. Continuous in vitro evolution of a ribozyme that catalyzes three successive nucleotidyl addition reactions. Chemistry & Biology. 9: 585-96. PMID 12031665 DOI: 10.1016/S1074-5521(02)00136-9  0.765
2002 McGinness KE, Joyce GF. RNA-catalyzed RNA ligation on an external RNA template. Chemistry & Biology. 9: 297-307. PMID 11927255 DOI: 10.1016/S1074-5521(02)00110-2  0.821
2002 McGinness KE, Joyce GF. Substitution of ribonucleotides in the T7 RNA polymerase promoter element. The Journal of Biological Chemistry. 277: 2987-91. PMID 11704669 DOI: 10.1074/Jbc.M108820200  0.782
2001 Joyce GF. RNA cleavage by the 10-23 DNA enzyme. Methods in Enzymology. 341: 503-17. PMID 11582801 DOI: 10.1016/S0076-6879(01)41173-6  0.532
2001 Rogers J, Joyce GF. The effect of cytidine on the structure and function of an RNA ligase ribozyme. Rna (New York, N.Y.). 7: 395-404. PMID 11333020 DOI: 10.1017/S135583820100228X  0.55
2000 Dai X, Joyce GF. In vitro evolution of a ribozyme that contains 5-bromouridine. Helvetica Chimica Acta. 83: 1701-10. PMID 11543569 DOI: 10.1002/1522-2675(20000809)83:8<1701::Aid-Hlca1701>3.0.Co;2-1  0.507
2000 Santoro SW, Joyce GF, Sakthivel K, Gramatikova S, Barbas CF 3rd. RNA cleavage by a DNA enzyme with extended chemical functionality. Journal of the American Chemical Society. 122: 2433-9. PMID 11543272 DOI: 10.1021/Ja993688S  0.484
2000 Joyce GF. RNA structure. Ribozyme evolution at the crossroads. Science (New York, N.Y.). 289: 401-2. PMID 10939951 DOI: 10.1126/Science.289.5478.401  0.502
2000 Sheppard TL, Ordoukhanian P, Joyce GF. A DNA enzyme with N-glycosylase activity. Proceedings of the National Academy of Sciences of the United States of America. 97: 7802-7. PMID 10884411 DOI: 10.1073/Pnas.97.14.7802  0.384
2000 Nowakowski J, Shim PJ, Stout CD, Joyce GF. Alternative conformations of a nucleic acid four-way junction. Journal of Molecular Biology. 300: 93-102. PMID 10864501 DOI: 10.1006/Jmbi.2000.3826  0.371
1999 Ordoukhanian P, Joyce GF. A molecular description of the evolution of resistance. Chemistry & Biology. 6: 881-9. PMID 10631516 DOI: 10.1016/S1074-5521(00)80007-1  0.471
1999 Jaeger L, Wright MC, Joyce GF. A complex ligase ribozyme evolved in vitro from a group I ribozyme domain. Proceedings of the National Academy of Sciences of the United States of America. 96: 14712-7. PMID 10611278 DOI: 10.1073/Pnas.96.26.14712  0.465
1999 Rogers J, Joyce GF. A ribozyme that lacks cytidine. Nature. 402: 323-5. PMID 10580507 DOI: 10.1038/46335  0.586
1999 Nowakowski J, Shim PJ, Joyce GF, Stout CD. Crystallization of the 10-23 DNA enzyme using a combinatorial screen of paired oligonucleotides. Acta Crystallographica. Section D, Biological Crystallography. 55: 1885-92. PMID 10531487 DOI: 10.1107/S0907444999010550  0.314
1999 Arrhenius G, Bada JL, Joyce GF, Lazcano A, Miller S, Orgel LE. Origin and ancestor: separate environments. Science (New York, N.Y.). 283: 792. PMID 10049121 DOI: 10.1126/Science.283.5403.791C  0.454
1999 Nowakowski J, Shim PJ, Prasad GS, Stout CD, Joyce GF. Crystal structure of an 82-nucleotide RNA-DNA complex formed by the 10-23 DNA enzyme. Nature Structural Biology. 6: 151-6. PMID 10048927 DOI: 10.1038/5839  0.385
1999 Joyce GF. APPENDIX 3: Reactions Catalyzed by RNA and DNA Enzymes Cold Spring Harbor Monograph Archive. 37: 687-690. DOI: 10.1101/087969589.37.687  0.525
1999 Joyce GF, Orgel LE. 2 Prospects for Understanding the Origin of the RNA World Cold Spring Harbor Monograph Archive. 37: 49-77. DOI: 10.1101/087969589.37.49  0.693
1998 Joyce GF, Orgel LE. The origins of life--a status report. The American Biology Teacher. 60: 10-2. PMID 11541103 DOI: 10.2307/4450404  0.463
1998 Santoro SW, Joyce GF. Mechanism and utility of an RNA-cleaving DNA enzyme. Biochemistry. 37: 13330-42. PMID 9748341 DOI: 10.1021/Bi9812221  0.465
1998 Joyce GF. Nucleic acid enzymes: playing with a fuller deck. Proceedings of the National Academy of Sciences of the United States of America. 95: 5845-7. PMID 9600881 DOI: 10.1073/Pnas.95.11.5845  0.587
1997 Hendrix M, Priestley ES, Joyce GF, Wong CH. Direct observation of aminoglycoside - RNA interactions by surface plasmon resonance Journal of the American Chemical Society. 119: 3641-3648. PMID 11540136 DOI: 10.1021/ja964290o  0.403
1997 Santoro SW, Joyce GF. A general purpose RNA-cleaving DNA enzyme Proceedings of the National Academy of Sciences of the United States of America. 94: 4262-4266. PMID 9113977 DOI: 10.1073/Pnas.94.9.4262  0.531
1997 Wright MC, Joyce GF. Continuous in vitro evolution of catalytic function. Science (New York, N.Y.). 276: 614-7. PMID 9110984 DOI: 10.1126/Science.276.5312.614  0.549
1997 Bruick RK, Koppitz M, Joyce GF, Orgel LE. A simple procedure for constructing 5'-amino-terminated oligodeoxynucleotides in aqueous solution. Nucleic Acids Research. 25: 1309-10. PMID 9092646 DOI: 10.1093/Nar/25.6.1309  0.479
1996 Tsang J, Joyce GF. Specialization of the DNA-cleaving activity of a group I ribozyme through in vitro evolution Journal of Molecular Biology. 262: 31-42. PMID 8809177 DOI: 10.1006/Jmbi.1996.0496  0.523
1996 Joyce GF. Ribozymes: Building the RNA world Current Biology. 6: 965-967. PMID 8805318 DOI: 10.1016/S0960-9822(02)00640-1  0.582
1996 Raillard SA, Joyce GF. Targeting sites within HIV-1 cDNA with a DNA-cleaving ribozyme Biochemistry. 35: 11693-11701. PMID 8794750 DOI: 10.1021/Bi960845G  0.351
1996 Tsang J, Joyce GF. In vitro evolution of randomized ribozymes Methods in Enzymology. 267: 410-425. PMID 8743329 DOI: 10.1016/S0076-6879(96)67025-6  0.426
1996 Bada JL, Arrhenlus G, Miller SL, Orgel L, Joyce G. The NASA specialized center of research and training (NSCORT) in exobiology Origins of Life and Evolution of the Biosphere. 26: 318-319. DOI: 10.1007/Bf02459783  0.422
1996 Joyce GF. The role of catalytic RNA in the origin and early evolution of life on earth Origins of Life and Evolution of the Biosphere. 26: 233-234. DOI: 10.1007/Bf02459730  0.508
1995 Breaker RR, Joyce GF. A DNA enzyme with Mg(2+)-dependent RNA phosphoesterase activity. Chemistry & Biology. 2: 655-60. PMID 9383471 DOI: 10.1016/1074-5521(95)90028-4  0.666
1995 Dai X, De Mesmaeker A, Joyce GF. Cleavage of an amide bond by a ribozyme Science. 267: 237-240. PMID 7809628 DOI: 10.1126/Science.7809628  0.343
1995 Breaker RR, Joyce GF. Self-incorporation of coenzymes by ribozymes. Journal of Molecular Evolution. 40: 551-8. PMID 7643406 DOI: 10.1007/Bf00160500  0.686
1994 Joyce GF. In vitro evolution of nucleic acids Current Opinion in Structural Biology. 4: 331-336. PMID 11539574 DOI: 10.1016/S0959-440X(94)90100-7  0.447
1994 Breaker RR, Joyce GF. A DNA enzyme that cleaves RNA. Chemistry & Biology. 1: 223-9. PMID 9383394 DOI: 10.1016/1074-5521(94)90014-0  0.681
1994 Tsang J, Joyce GF. Evolutionary optimization of the catalytic properties of a DNA-cleaving ribozyme. Biochemistry. 33: 5966-73. PMID 8180226 DOI: 10.1021/Bi00185A038  0.383
1994 Chakrabarti AC, Breaker RR, Joyce GF, Deamer DW. Production of RNA by a polymerase protein encapsulated within phospholipid vesicles. Journal of Molecular Evolution. 39: 555-9. PMID 7528810 DOI: 10.1007/Bf00160400  0.69
1994 Breaker RR, Banerji A, Joyce GF. Continuous in vitro evolution of bacteriophage RNA polymerase promoters. Biochemistry. 33: 11980-6. PMID 7522554 DOI: 10.1021/Bi00205A037  0.69
1994 Breaker RR, Joyce GF. Inventing and improving ribozyme function: rational design versus iterative selection methods. Trends in Biotechnology. 12: 268-75. PMID 7519862 DOI: 10.1016/0167-7799(94)90138-4  0.555
1994 Breaker RR, Joyce GF. Emergence of a replicating species from an in vitro RNA evolution reaction. Proceedings of the National Academy of Sciences of the United States of America. 91: 6093-7. PMID 7517040 DOI: 10.1073/Pnas.91.13.6093  0.728
1993 Lehman N, Joyce GF. Evolution in vitro: analysis of a lineage of ribozymes Current Biology. 3: 723-734. PMID 11539560 DOI: 10.1016/0960-9822(93)90019-K  0.709
1993 Joyce GF. Climbing Darwin's ladder Current Biology. 3: 703-704. PMID 11539460 DOI: 10.1016/0960-9822(93)90074-X  0.583
1993 Joyce GF. Evolution of catalytic function Pure and Applied Chemistry. 65: 1205-1212. PMID 11537489 DOI: 10.1351/Pac199365061205  0.482
1993 Lehman N, Joyce GF. Evolution in vitro of an RNA enzyme with altered metal dependence Nature. 361: 182-185. PMID 8421526 DOI: 10.1038/361182A0  0.696
1993 Joyce GF, Orgel LE. 1 Prospects for Understanding the Origin of the RNA World Cold Spring Harbor Monograph Archive. 24: 1-25. DOI: 10.1101/087969380.24.1  0.694
1992 Beaudry AA, Joyce GF. Directed evolution of an RNA enzyme Science. 257: 635-641. PMID 1496376 DOI: 10.1126/Science.1496376  0.546
1991 Joyce GF. RNA today New Biologist. 3: 565-569. PMID 1716983  0.457
1991 Joyce GF. The rise and fall of the RNA world New Biologist. 3: 399-407. PMID 1712228  0.474
1990 Beaudry AA, Joyce GF. Minimum secondary structure requirements for catalytic activity of a self-splicing group I intron Biochemistry. 29: 6534-6539. PMID 2207095 DOI: 10.1021/Bi00479A027  0.331
1990 Robertson DL, Joyce GF. Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA Nature. 344: 467-468. PMID 1690861 DOI: 10.1038/344467A0  0.583
1989 Joyce GF. Amplification, mutation and selection of catalytic RNA Gene. 82: 83-87. PMID 2684778 DOI: 10.1016/0378-1119(89)90033-4  0.561
1989 Joyce GF, van der Horst G, Inoue T. Catalytic activity is retained in the Tetrahymena group I intron despite removal of the large extension of element P5 Nucleic Acids Research. 17: 7879-7889. PMID 2477801 DOI: 10.1093/Nar/17.19.7879  0.341
1989 Joyce GF. RNA evolution and the origins of life Nature. 338: 217-224. PMID 2466202 DOI: 10.1038/338217A0  0.536
1989 Joyce GF, Inoue T. A novel technique for the rapid preparation of mutant RNAs Nucleic Acids Research. 17: 711-722. PMID 2464798  0.38
1989 Joyce GF. Evolution of catalytic rna in the laboratory Origins of Life and Evolution of the Biosphere. 19: 331-331. DOI: 10.1007/Bf02388876  0.576
1988 Joyce GF, Orgel LE. Non-enzymatic template-directed synthesis on RNA random copolymers. Poly(C,A) templates. Journal of Molecular Biology. 202: 677-81. PMID 2459395 DOI: 10.1016/0022-2836(88)90297-5  0.553
1987 Joyce GF, Inoue T. Structure of the catalytic core of the tetrahymena ribozyme as indicated by reactive abbreviated forms of the molecule Nucleic Acids Research. 15: 9825-9840. PMID 3697083 DOI: 10.1093/Nar/15.23.9825  0.38
1987 Joyce GF, Schwartz AW, Miller SL, Orgel LE. The case for an ancestral genetic system involving simple analogues of the nucleotides. Proceedings of the National Academy of Sciences of the United States of America. 84: 4398-402. PMID 2440020 DOI: 10.1073/Pnas.84.13.4398  0.676
1986 Joyce GF, Orgel LE. Non-enzymic template-directed synthesis on RNA random copolymers. Poly(C, G) templates. Journal of Molecular Biology. 188: 433-41. PMID 2426455 DOI: 10.1016/0022-2836(86)90166-X  0.493
1986 Joyce GF, Orgel LE. Consequences of template self-structure in poly(C,G)-directed synthesis of oligo(G,C)s Origins of Life and Evolution of the Biosphere. 16: 458-458. DOI: 10.1007/Bf02422133  0.477
1986 Joyce GF, Orgel LE, Miller SL. Chiral selection in template-directed RNA synthesis and the case for a prochiral ancestor of RNA Origins of Life and Evolution of the Biosphere. 16: 445-445. DOI: 10.1007/Bf02422125  0.665
1984 Joyce GF, Tschirgi RD. Automata simulation of the selection process. Bio Systems. 17: 65-72. PMID 6743795 DOI: 10.1016/0303-2647(84)90017-0  0.723
1984 Joyce GF, Visser GM, van Boeckel CA, van Boom JH, Orgel LE, van Westrenen J. Chiral selection in poly(C)-directed synthesis of oligo(G). Nature. 310: 602-4. PMID 6462250 DOI: 10.1038/310602A0  0.531
1984 Joyce GF. Non-enzymatic template-directed synthesis of RNA copolymers Origins of Life. 14: 613-620. PMID 6205345 DOI: 10.1007/Bf00933711  0.46
1984 Joyce GF, Inoue T, Orgel LE. Non-enzymatic template-directed synthesis on RNA random copolymers. Poly(C, U) templates. Journal of Molecular Biology. 176: 279-306. PMID 6205154 DOI: 10.1016/0022-2836(84)90425-X  0.574
1984 Inoue T, Joyce GF, Grzeskowiak K, Orgel LE, Brown JM, Reese CB. Template-directed synthesis on the pentanucleotide CpCpGpCpC. Journal of Molecular Biology. 178: 669-76. PMID 6092644 DOI: 10.1016/0022-2836(84)90244-4  0.551
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