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Colleen Clancy - Publications

Affiliations: 
Weill Cornell Medical College, New York, NY, United States 
Area:
General Biophysics, Neuroscience Biology, Animal Physiology Biology
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48 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Yang PC, Rose A, DeMarco KR, Dawson JRD, Han Y, Jeng MT, Harvey RD, Santana LF, Ripplinger CM, Vorobyov I, Lewis TJ, Clancy CE. A multiscale predictive digital twin for neurocardiac modulation. The Journal of Physiology. PMID 37528537 DOI: 10.1113/JP284391  0.324
2022 Maly J, Emigh AM, DeMarco KR, Furutani K, Sack JT, Clancy CE, Vorobyov I, Yarov-Yarovoy V. Structural modeling of the hERG potassium channel and associated drug interactions. Frontiers in Pharmacology. 13: 966463. PMID 36188564 DOI: 10.3389/fphar.2022.966463  0.306
2022 Furutani K, Kawano R, Ichiwara M, Adachi R, Clancy CE, Sack JT, Kita S. Pore opening, not voltage sensor movement, underpins the voltage-dependence of facilitation by a hERG blocker. Molecular Pharmacology. PMID 36041862 DOI: 10.1124/molpharm.122.000569  0.31
2021 Docken SS, Clancy CE, Lewis TJ. Rate-dependent effects of lidocaine on cardiac dynamics: Development and analysis of a low-dimensional drug-channel interaction model. Plos Computational Biology. 17: e1009145. PMID 34185778 DOI: 10.1371/journal.pcbi.1009145  0.308
2021 Yang PC, Giles WR, Belardinelli L, Clancy CE. Mechanisms of flecainide induced negative inotropy: An in silico study. Journal of Molecular and Cellular Cardiology. PMID 34004185 DOI: 10.1016/j.yjmcc.2021.05.007  0.372
2018 Perissinotti LL, De Biase PM, Guo J, Yang PC, Lee MC, Clancy CE, Duff HJ, Noskov SY. Determinants of Isoform-Specific Gating Kinetics of hERG1 Channel: Combined Experimental and Simulation Study. Frontiers in Physiology. 9: 207. PMID 29706893 DOI: 10.3389/Fphys.2018.00207  0.365
2016 Yang PC, Moreno JD, Jeng MT, Wehrens XH, Noskov S, Clancy CE. Reply from Pei-Chi Yang, Jonathan D. Moreno, Mao-Tsuen Jeng, Xander H. T. Wehrens, Sergei Noskov and Colleen E. Clancy. The Journal of Physiology. 594: 6433-6435. PMID 27800622 DOI: 10.1113/Jp273143  0.433
2016 DeMarco KR, Clancy CE. Cardiac Na Channels: Structure to Function. Current Topics in Membranes. 78: 287-311. PMID 27586288 DOI: 10.1016/bs.ctm.2016.05.001  0.305
2016 Yang PC, El-Bizri N, Romero L, Giles WR, Rajamani S, Belardinelli L, Clancy CE. A computational model predicts adjunctive pharmacotherapy for cardiac safety via selective inhibition of the late cardiac Na current. Journal of Molecular and Cellular Cardiology. PMID 27545042 DOI: 10.1016/J.Yjmcc.2016.08.011  0.322
2016 Moreno JD, Lewis TJ, Clancy CE. Parameterization for In-Silico Modeling of Ion Channel Interactions with Drugs. Plos One. 11: e0150761. PMID 26963710 DOI: 10.1371/Journal.Pone.0150761  0.559
2016 Gray B, Bagnall R, Lam L, Ingles J, Turner C, Haan E, Davis A, Yang P, Clancy C, Sy R, Semsarian C. A Novel Heterozygous Mutation in Cardiac Calsequestrin Causes Catecholaminergic Polymorphic Ventricular Tachycardia Heart, Lung and Circulation. 25: S2-S3. DOI: 10.1016/J.Hlc.2016.06.005  0.34
2016 Vincent M, Yang P, Clancy CE. A Computational Modeling Investigation into SCN10A Linked Brugada Syndrome Biophysical Journal. 110: 107a-108a. DOI: 10.1016/J.Bpj.2015.11.637  0.36
2016 Yang P, Boras B, Jeng M, Docken S, Lewis T, McCulloch A, Harvey R, Clancy C. A Computational Investigation Predicts Mechanisms of Subcellular cAMP Compartmentation Biophysical Journal. 110: 590a. DOI: 10.1016/J.Bpj.2015.11.3151  0.364
2015 Romero L, Trenor B, Yang PC, Saiz J, Clancy CE. In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome. Journal of Molecular and Cellular Cardiology. 87: 271-82. PMID 26859003  0.337
2015 Yang PC, Moreno JD, Miyake CY, Vaughn-Behrens SB, Jeng MT, Grandi E, Wehrens XH, Noskov S, Clancy CE. In silico prediction of drug therapy in catecholaminergic polymorphic ventricular tachycardia. The Journal of Physiology. PMID 26515697 DOI: 10.1113/Jp271282  0.599
2015 Perissinotti LL, Guo J, De Biase PM, Clancy CE, Duff HJ, Noskov SY. Kinetic model for NS1643 drug activation of WT and L529I variants of Kv11.1 (hERG1) potassium channel. Biophysical Journal. 108: 1414-24. PMID 25809254 DOI: 10.1016/J.Bpj.2014.12.056  0.328
2015 Clancy CE, Chen-Izu Y, Bers DM, Belardinelli L, Boyden PA, Csernoch L, Despa S, Fermini B, Hool LC, Izu L, Kass RS, Lederer WJ, Louch WE, Maack C, Matiazzi A, et al. Deranged sodium to sudden death. The Journal of Physiology. 593: 1331-45. PMID 25772289 DOI: 10.1113/Jphysiol.2014.281204  0.318
2015 Yang PC, Song Y, Giles WR, Horvath B, Chen-Izu Y, Belardinelli L, Rajamani S, Clancy CE. A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na+ current. The Journal of Physiology. 593: 1429-42. PMID 25545172 DOI: 10.1113/jphysiol.2014.279554  0.346
2014 Romero L, Trenor B, Yang PC, Saiz J, Clancy CE. In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome. Journal of Molecular and Cellular Cardiology. 72: 126-37. PMID 24631769 DOI: 10.1016/j.yjmcc.2014.02.018  0.339
2014 Agarwal SR, Yang P, Clancy C, Harvey R. Compartmentation of Camp Signaling in Complex and Simple Cells Biophysical Journal. 106: 776a-777a. DOI: 10.1016/J.Bpj.2013.11.4258  0.317
2013 Moreno JD, Yang PC, Bankston JR, Grandi E, Bers DM, Kass RS, Clancy CE. Ranolazine for congenital and acquired late INa-linked arrhythmias: in silico pharmacological screening. Circulation Research. 113: e50-61. PMID 23897695 DOI: 10.1161/Circresaha.113.301971  0.75
2013 Nawathe PA, Kryukova Y, Oren RV, Milanesi R, Clancy CE, Lu JT, Moss AJ, Difrancesco D, Robinson RB. An LQTS6 MiRP1 mutation suppresses pacemaker current and is associated with sinus bradycardia. Journal of Cardiovascular Electrophysiology. 24: 1021-7. PMID 23631727 DOI: 10.1111/Jce.12163  0.733
2013 Lewin N, Aksay E, Clancy CE. Correction: Computational Modeling Reveals Dendritic Origins of GABAA-Mediated Excitation in CA1 Pyramidal Neurons Plos One. 8. DOI: 10.1371/Annotation/D6Af29Ee-25C0-4F8E-910E-Afe53Ef8F963  0.718
2012 Lewin N, Aksay E, Clancy CE. Computational modeling reveals dendritic origins of GABA(A)-mediated excitation in CA1 pyramidal neurons. Plos One. 7: e47250. PMID 23071770 DOI: 10.1371/Journal.Pone.0047250  0.729
2012 Roberts BN, Yang PC, Behrens SB, Moreno JD, Clancy CE. Computational approaches to understand cardiac electrophysiology and arrhythmias. American Journal of Physiology. Heart and Circulatory Physiology. 303: H766-83. PMID 22886409 DOI: 10.1152/Ajpheart.01081.2011  0.577
2012 Moreno JD, Clancy CE. Pathophysiology of the cardiac late Na current and its potential as a drug target. Journal of Molecular and Cellular Cardiology. 52: 608-19. PMID 22198344 DOI: 10.1016/J.Yjmcc.2011.12.003  0.622
2011 Moreno JD, Zhu ZI, Yang PC, Bankston JR, Jeng MT, Kang C, Wang L, Bayer JD, Christini DJ, Trayanova NA, Ripplinger CM, Kass RS, Clancy CE. A computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythms. Science Translational Medicine. 3: 98ra83. PMID 21885405 DOI: 10.1126/Scitranslmed.3002588  0.754
2010 Oren RV, Clancy CE. Determinants of heterogeneity, excitation and conduction in the sinoatrial node: a model study. Plos Computational Biology. 6: e1001041. PMID 21203483 DOI: 10.1371/Journal.Pcbi.1001041  0.729
2010 Yang PC, Kurokawa J, Furukawa T, Clancy CE. Acute effects of sex steroid hormones on susceptibility to cardiac arrhythmias: a simulation study. Plos Computational Biology. 6: e1000658. PMID 20126530 DOI: 10.1371/Journal.Pcbi.1000658  0.309
2010 Protas L, Oren RV, Clancy CE, Robinson RB. Age-dependent changes in Na current magnitude and TTX-sensitivity in the canine sinoatrial node. Journal of Molecular and Cellular Cardiology. 48: 172-80. PMID 19665465 DOI: 10.1016/J.Yjmcc.2009.07.028  0.728
2010 Moreno JD, Bankston JR, Kass RS, Clancy C. Cardiac Dynamics In-Silico: Pharmacological Targeting of Long QT3 Syndrome Biophysical Journal. 98: 8a. DOI: 10.1016/J.Bpj.2009.12.050  0.756
2009 Moreno JD, Clancy CE. Using computational modeling to predict arrhythmogenesis and antiarrhythmic therapy. Drug Discovery Today. Disease Models. 6: 71-84. PMID 20652086 DOI: 10.1016/J.Ddmod.2010.03.001  0.603
2009 Zhao X, Bucchi A, Oren RV, Kryukova Y, Dun W, Clancy CE, Robinson RB. In vitro characterization of HCN channel kinetics and frequency dependence in myocytes predicts biological pacemaker functionality. The Journal of Physiology. 587: 1513-25. PMID 19171659 DOI: 10.1113/Jphysiol.2008.163444  0.737
2008 Furukawa T, Kurokawa J, Clancy CE. A Combined Approach Using Patch-Clamp Study and Computer Simulation Study for Understanding Long QT Syndrome and TdP in Women. Current Cardiology Reviews. 4: 244-50. PMID 20066131 DOI: 10.2174/157340308786349507  0.336
2007 Nakamura H, Kurokawa J, Bai CX, Asada K, Xu J, Oren RV, Zhu ZI, Clancy CE, Isobe M, Furukawa T. Progesterone regulates cardiac repolarization through a nongenomic pathway: an in vitro patch-clamp and computational modeling study. Circulation. 116: 2913-22. PMID 18056530 DOI: 10.1161/Circulationaha.107.702407  0.722
2007 Zhu ZI, Clancy CE. Genetic mutations and arrhythmia: simulation from DNA to electrocardiogram. Journal of Electrocardiology. 40: S47-50. PMID 17993328 DOI: 10.1016/j.jelectrocard.2007.05.033  0.338
2007 Zhu ZI, Clancy CE. L-type Ca2+ channel mutations and T-wave alternans: a model study. American Journal of Physiology. Heart and Circulatory Physiology. 293: H3480-9. PMID 17933974 DOI: 10.1152/ajpheart.00476.2007  0.337
2007 Clancy CE, Wehrens XH. Mutation-specific effects of lidocaine in Brugada syndrome. International Journal of Cardiology. 121: 249-52. PMID 17761312 DOI: 10.1016/j.ijcard.2007.05.060  0.32
2007 Clancy CE, Zhu ZI, Rudy Y. Pharmacogenetics and anti-arrhythmic drug therapy: a theoretical investigation. American Journal of Physiology. Heart and Circulatory Physiology. 292: H66-75. PMID 16997895 DOI: 10.1152/Ajpheart.00312.2006  0.316
2006 Choe CU, Schulze-Bahr E, Neu A, Xu J, Zhu ZI, Sauter K, Bähring R, Priori S, Guicheney P, Mönnig G, Neapolitano C, Heidemann J, Clancy CE, Pongs O, Isbrandt D. C-terminal HERG (LQT2) mutations disrupt IKr channel regulation through 14-3-3epsilon. Human Molecular Genetics. 15: 2888-902. PMID 16923798 DOI: 10.1093/Hmg/Ddl230  0.305
2006 Glaaser IW, Clancy CE. Cardiac Na+ channels as therapeutic targets for antiarrhythmic agents. Handbook of Experimental Pharmacology. 99-121. PMID 16610342 DOI: 10.1007/3-540-29715-4_4  0.314
2005 Terrenoire C, Clancy CE, Cormier JW, Sampson KJ, Kass RS. Autonomic control of cardiac action potentials: role of potassium channel kinetics in response to sympathetic stimulation. Circulation Research. 96: e25-34. PMID 15731462 DOI: 10.1161/01.Res.0000160555.58046.9A  0.307
2005 Clancy CE, Kass RS. Inherited and acquired vulnerability to ventricular arrhythmias: cardiac Na+ and K+ channels. Physiological Reviews. 85: 33-47. PMID 15618477 DOI: 10.1152/physrev.00005.2004  0.316
2003 Clancy CE, Tateyama M, Liu H, Wehrens XH, Kass RS. Non-equilibrium gating in cardiac Na+ channels: an original mechanism of arrhythmia. Circulation. 107: 2233-7. PMID 12695286 DOI: 10.1161/01.CIR.0000069273.51375.BD  0.338
2002 Clancy CE, Tateyama M, Kass RS. Insights into the molecular mechanisms of bradycardia-triggered arrhythmias in long QT-3 syndrome. The Journal of Clinical Investigation. 110: 1251-62. PMID 12417563 DOI: 10.1172/JCI15928  0.32
2002 Clancy CE, Kass RS. Defective cardiac ion channels: from mutations to clinical syndromes. The Journal of Clinical Investigation. 110: 1075-7. PMID 12393842 DOI: 10.1172/JCI16945  0.361
2002 Rivolta I, Clancy CE, Tateyama M, Liu H, Priori SG, Kass RS. A novel SCN5A mutation associated with long QT-3: altered inactivation kinetics and channel dysfunction. Physiological Genomics. 10: 191-7. PMID 12209021 DOI: 10.1152/physiolgenomics.00039.2002  0.334
2001 Clancy CE, Rudy Y. Cellular consequences of HERG mutations in the long QT syndrome: Precursors to sudden cardiac death Cardiovascular Research. 50: 301-313. PMID 11334834 DOI: 10.1016/S0008-6363(00)00293-5  0.352
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