| Year |
Citation |
Score |
| 2023 |
Martin AP, Bradshaw GA, Eisert RJ, Egan ED, Tveriakhina L, Rogers JM, Dates AN, Scanavachi G, Aster JC, Kirchhausen T, Kalocsay M, Blacklow SC. A spatiotemporal Notch interaction map from plasma membrane to nucleus. Science Signaling. 16: eadg6474. PMID 37527352 DOI: 10.1126/scisignal.adg6474 |
0.303 |
|
| 2023 |
Jones DTD, Dates AN, Rawson SD, Burruss MM, Lipper CH, Blacklow SC. Tethered agonist activated ADGRF1 structure and signalling analysis reveal basis for G protein coupling. Nature Communications. 14: 2490. PMID 37120430 DOI: 10.1038/s41467-023-38083-7 |
0.38 |
|
| 2022 |
Khamaisi B, Luca VC, Blacklow SC, Sprinzak D. Functional Comparison between Endogenous and Synthetic Notch Systems. Acs Synthetic Biology. PMID 36107643 DOI: 10.1021/acssynbio.2c00247 |
0.346 |
|
| 2022 |
Gonzalez-Perez D, Das S, Antfolk D, Ahsan HS, Medina E, Dundes CE, Jokhai RT, Egan ED, Blacklow SC, Loh KM, Rodriguez PC, Luca VC. Affinity-matured DLL4 ligands as broad-spectrum modulators of Notch signaling. Nature Chemical Biology. PMID 36050494 DOI: 10.1038/s41589-022-01113-4 |
0.376 |
|
| 2021 |
Lipper CH, Gabriel KH, Seegar TCM, Dürr KL, Tomlinson MG, Blacklow SC. Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site. Structure (London, England : 1993). PMID 34739841 DOI: 10.1016/j.str.2021.10.007 |
0.328 |
|
| 2021 |
Vemulapalli V, Chylek LA, Erickson A, Pfeiffer A, Gabriel KH, LaRochelle J, Subramanian K, Cao R, Stegmaier K, Mohseni M, LaMarche MJ, Acker MG, Sorger PK, Gygi SP, Blacklow SC. Time resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling. Elife. 10. PMID 33755016 DOI: 10.7554/eLife.64251 |
0.803 |
|
| 2021 |
Sprinzak D, Blacklow SC. Biophysics of Notch Signaling. Annual Review of Biophysics. PMID 33534608 DOI: 10.1146/annurev-biophys-101920-082204 |
0.31 |
|
| 2020 |
Pan L, Lemieux ME, Thomas T, Rogers JM, Lipper CH, Lee W, Johnson C, Sholl LM, South AP, Marto JA, Adelmant GO, Blacklow SC, Aster JC. , a DNA damage response gene, is required for Notch-mediated induction of squamous cell differentiation. Elife. 9. PMID 32936072 DOI: 10.7554/Elife.58081 |
0.333 |
|
| 2020 |
Lehal R, Zaric J, Vigolo M, Urech C, Frismantas V, Zangger N, Cao L, Berger A, Chicote I, Loubéry S, Choi SH, Koch U, Blacklow SC, Palmer HG, Bornhauser B, et al. Pharmacological disruption of the Notch transcription factor complex. Proceedings of the National Academy of Sciences of the United States of America. PMID 32601208 DOI: 10.1073/Pnas.1922606117 |
0.442 |
|
| 2020 |
Rogers JM, Guo B, Egan ED, Aster JC, Adelman K, Blacklow SC. MAML1-dependent Notch responsive genes exhibit differing co-factor requirements for transcriptional activation. Molecular and Cellular Biology. PMID 32179552 DOI: 10.1128/Mcb.00014-20 |
0.409 |
|
| 2020 |
Rome KS, Stein SJ, Kurachi M, Petrovic J, Schwartz GW, Mack EA, Uljon S, Wu WW, DeHart AG, McClory SE, Xu L, Gimotty PA, Blacklow SC, Faryabi RB, Wherry EJ, et al. Trib1 regulates T cell differentiation during chronic infection by restraining the effector program. The Journal of Experimental Medicine. 217. PMID 32150623 DOI: 10.1084/Jem.20190888 |
0.334 |
|
| 2019 |
Jarrett SM, Seegar TCM, Andrews M, Adelmant G, Marto JA, Aster JC, Blacklow SC. Extension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling. Science Signaling. 12. PMID 31690634 DOI: 10.1126/Scisignal.Aay2369 |
0.486 |
|
| 2019 |
Seegar TC, Blacklow SC. Domain integration of ADAM family proteins: Emerging themes from structural studies. Experimental Biology and Medicine (Maywood, N.J.). 1535370219865901. PMID 31333048 DOI: 10.1177/1535370219865901 |
0.357 |
|
| 2019 |
Rogers JM, Waters CT, Seegar TCM, Jarrett SM, Hallworth AN, Blacklow SC, Bulyk ML. Bispecific Forkhead Transcription Factor FoxN3 Recognizes Two Distinct Motifs with Different DNA Shapes. Molecular Cell. PMID 30826165 DOI: 10.1016/J.Molcel.2019.01.019 |
0.332 |
|
| 2019 |
Petrovic J, Zhou Y, Fasolino M, Goldman N, Schwartz GW, Mumbach MR, Nguyen SC, Rome KS, Sela Y, Zapataro Z, Blacklow SC, Kruhlak MJ, Shi J, Aster JC, Joyce EF, et al. Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques. Molecular Cell. PMID 30745086 DOI: 10.1016/J.Molcel.2019.01.006 |
0.333 |
|
| 2018 |
LaRochelle JR, Fodor M, Vemulapalli V, Mohseni M, Wang P, Stams T, LaMarche MJ, Chopra R, Acker MG, Blacklow SC. Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition. Nature Communications. 9: 4508. PMID 30375388 DOI: 10.1038/s41467-018-06823-9 |
0.798 |
|
| 2018 |
Tveriakhina L, Schuster-Gossler K, Jarrett SM, Andrawes MB, Rohrbach M, Blacklow SC, Gossler A. The ectodomains determine ligand function and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 . Elife. 7. PMID 30289388 DOI: 10.7554/Elife.40045 |
0.443 |
|
| 2018 |
Lovendahl KN, Blacklow SC, Gordon WR. The Molecular Mechanism of Notch Activation. Advances in Experimental Medicine and Biology. 1066: 47-58. PMID 30030821 DOI: 10.1007/978-3-319-89512-3_3 |
0.428 |
|
| 2018 |
Fodor M, Price E, Wang P, Lu H, Argintaru A, Chen Z, Glick M, Hao HX, Kato M, Koenig R, LaRochelle JR, Liu G, McNeill E, Majumdar D, Nishiguchi GA, ... ... Blacklow SC, et al. Dual Allosteric Inhibition of SHP2 Phosphatase. Acs Chemical Biology. PMID 29304282 DOI: 10.1021/Acschembio.7B00980 |
0.774 |
|
| 2018 |
Tveriakhina L, Schuster-Gossler K, Jarrett SM, Andrawes MB, Rohrbach M, Blacklow SC, Gossler A. Author response: The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro Elife. DOI: 10.7554/Elife.40045.030 |
0.328 |
|
| 2017 |
Seegar TCM, Killingsworth LB, Saha N, Meyer PA, Patra D, Zimmerman B, Janes PW, Rubinstein E, Nikolov DB, Skiniotis G, Kruse AC, Blacklow SC. Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10. Cell. 171: 1638-1648.e7. PMID 29224781 DOI: 10.1016/J.Cell.2017.11.014 |
0.444 |
|
| 2017 |
Pajcini KV, Xu L, Shao L, Petrovic J, Palasiewicz K, Ohtani Y, Bailis W, Lee C, Wertheim GB, Mani R, Musuthamy N, Li Y, Meijerink JPP, Blacklow SC, Faryabi RB, et al. MAFB enhances oncogenic Notch signaling in T cell acute lymphoblastic leukemia. Science Signaling. 10. PMID 29138297 DOI: 10.1126/Scisignal.Aam6846 |
0.433 |
|
| 2017 |
LaRochelle JR, Fodor M, Ellegast JM, Liu X, Vemulapalli V, Mohseni M, Stams T, Buhrlage SJ, Stegmaier K, LaMarche MJ, Acker MG, Blacklow SC. Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2. Bioorganic & Medicinal Chemistry. PMID 29089257 DOI: 10.1016/J.Bmc.2017.10.025 |
0.792 |
|
| 2017 |
Ryan RJH, Petrovic J, Rausch DM, Zhou Y, Lareau CA, Kluk MJ, Christie AL, Lee WY, Tarjan DR, Guo B, Donohue LKH, Gillespie SM, Nardi V, Hochberg EP, Blacklow SC, et al. A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas. Cell Reports. 21: 784-797. PMID 29045844 DOI: 10.1016/J.Celrep.2017.09.066 |
0.378 |
|
| 2017 |
Choi SH, Severson E, Pear WS, Liu XS, Aster JC, Blacklow SC. The common oncogenomic program of NOTCH1 and NOTCH3 signaling in T-cell acute lymphoblastic leukemia. Plos One. 12: e0185762. PMID 29023469 DOI: 10.1371/Journal.Pone.0185762 |
0.417 |
|
| 2017 |
Sajed DP, Faquin WC, Carey C, Severson EA, H Afrogheh A, A Johnson C, Blacklow SC, Chau NG, Lin DT, Krane JF, Jo VY, Garcia JJ, Sholl LM, Aster JC. Diffuse Staining for Activated NOTCH1 Correlates With NOTCH1 Mutation Status and is Associated With Worse Outcome in Adenoid Cystic Carcinoma. The American Journal of Surgical Pathology. PMID 28914715 DOI: 10.1097/Pas.0000000000000945 |
0.326 |
|
| 2017 |
McMillan BJ, Tibbe C, Drabek AA, Seegar TCM, Blacklow SC, Klein T. Structural Basis for Regulation of ESCRT-III Complexes by Lgd. Cell Reports. 19: 1750-1757. PMID 28564595 DOI: 10.1016/J.Celrep.2017.05.026 |
0.418 |
|
| 2017 |
Blacklow SC. Signal Transduction: Notch catches a Jagged edge. Nature Chemical Biology. 13: 570-571. PMID 28514425 DOI: 10.1038/Nchembio.2379 |
0.37 |
|
| 2017 |
Severson E, Arnett KL, Wang H, Zang C, Taing L, Liu H, Pear WS, Shirley Liu X, Blacklow SC, Aster JC. Genome-wide identification and characterization of Notch transcription complex-binding sequence-paired sites in leukemia cells. Science Signaling. 10. PMID 28465412 DOI: 10.1126/Scisignal.Aag1598 |
0.402 |
|
| 2017 |
McMillan BJ, Zimmerman B, Egan ED, Lofgren M, Xu X, Hesser A, Blacklow SC. Structure of human POFUT1, its requirement in ligand-independent oncogenic Notch signaling, and functional effects of Dowling-Degos mutations. Glycobiology. 1-10. PMID 28334865 DOI: 10.1093/Glycob/Cwx020 |
0.498 |
|
| 2017 |
Acker MG, Chen YP, LaMarche MJ, Chan HM, Fekkes P, Garcia-Fortanet J, LaRochelle JR, Antonakos B, Chen CH, Chen Z, Cooke VG, Dobson JR, Deng Z, Feng F, Firestone B, ... ... Blacklow SC, et al. Abstract 2084: Conformational activation and allosteric inhibition of SHP2 in RTK-driven cancers Cancer Research. 77: 2084-2084. DOI: 10.1158/1538-7445.Am2017-2084 |
0.758 |
|
| 2016 |
Durzynska I, Xu X, Adelmant G, Ficarro SB, Marto JA, Sliz P, Uljon S, Blacklow SC. STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1. Structure (London, England : 1993). PMID 28089446 DOI: 10.1016/J.Str.2016.12.008 |
0.41 |
|
| 2016 |
Aster JC, Pear WS, Blacklow SC. The Varied Roles of Notch in Cancer. Annual Review of Pathology. PMID 27959635 DOI: 10.1146/Annurev-Pathol-052016-100127 |
0.372 |
|
| 2016 |
Zimmerman B, Kelly B, McMillan BJ, Seegar TC, Dror RO, Kruse AC, Blacklow SC. Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket. Cell. 167: 1041-1051.e11. PMID 27881302 DOI: 10.1016/J.Cell.2016.09.056 |
0.362 |
|
| 2016 |
McMillan BJ, Tibbe C, Jeon H, Drabek AA, Klein T, Blacklow SC. Electrostatic Interactions between Elongated Monomers Drive Filamentation of Drosophila Shrub, a Metazoan ESCRT-III Protein. Cell Reports. PMID 27452459 DOI: 10.1016/J.Celrep.2016.06.093 |
0.35 |
|
| 2016 |
Guo B, McMillan BJ, Blacklow SC. Structure and function of the Mind bomb E3 ligase in the context of Notch signal transduction. Current Opinion in Structural Biology. 41: 38-45. PMID 27285058 DOI: 10.1016/J.Sbi.2016.05.012 |
0.442 |
|
| 2016 |
Bernasconi-Elias P, Hu T, Jenkins D, Firestone B, Gans S, Kurth E, Capodieci P, Deplazes-Lauber J, Petropoulos K, Thiel P, Ponsel D, Hee Choi S, LeMotte P, London A, Goetcshkes M, ... ... Blacklow SC, et al. Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies. Oncogene. PMID 27157619 DOI: 10.1038/Onc.2016.133 |
0.439 |
|
| 2016 |
Uljon S, Xu X, Durzynska I, Stein S, Adelmant G, Marto JA, Pear WS, Blacklow SC. Structural Basis for Substrate Selectivity of the E3 Ligase COP1. Structure (London, England : 1993). PMID 27041596 DOI: 10.1016/J.Str.2016.03.002 |
0.422 |
|
| 2016 |
LaRochelle JR, Fodor M, Xu X, Durzynska I, Fan L, Stams T, Chan H, LaMarche MJ, Chopra R, Wang P, Fortin PD, Acker MG, Blacklow SC. Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2. Biochemistry. PMID 27030275 DOI: 10.1021/Acs.Biochem.5B01287 |
0.768 |
|
| 2016 |
Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, et al. Data publication with the structural biology data grid supports live analysis. Nature Communications. 7: 10882. PMID 26947396 DOI: 10.1038/Ncomms10882 |
0.731 |
|
| 2015 |
Xu X, Choi SH, Hu T, Tiyanont K, Habets R, Groot AJ, Vooijs M, Aster JC, Chopra R, Fryer C, Blacklow SC. Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region. Structure (London, England : 1993). 23: 1227-35. PMID 26051713 DOI: 10.1016/J.Str.2015.05.001 |
0.517 |
|
| 2015 |
Gordon WR, Zimmerman B, He L, Miles LJ, Huang J, Tiyanont K, McArthur DG, Aster JC, Perrimon N, Loparo JJ, Blacklow SC. Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch. Developmental Cell. 33: 729-36. PMID 26051539 DOI: 10.1016/J.Devcel.2015.05.004 |
0.418 |
|
| 2015 |
Habets RA, Groot AJ, Yahyanejad S, Tiyanont K, Blacklow SC, Vooijs M. Human NOTCH2 Is Resistant to Ligand-independent Activation by Metalloprotease Adam17. The Journal of Biological Chemistry. 290: 14705-16. PMID 25918160 DOI: 10.1074/Jbc.M115.643676 |
0.469 |
|
| 2015 |
McMillan BJ, Schnute B, Ohlenhard N, Zimmerman B, Miles L, Beglova N, Klein T, Blacklow SC. A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb E3 ligases. Molecular Cell. 57: 912-24. PMID 25747658 DOI: 10.1016/J.Molcel.2015.01.019 |
0.476 |
|
| 2014 |
Yashiro-Ohtani Y, Wang H, Zang C, Arnett KL, Bailis W, Ho Y, Knoechel B, Lanauze C, Louis L, Forsyth KS, Chen S, Chung Y, Schug J, Blobel GA, Liebhaber SA, ... ... Blacklow SC, et al. Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia. Proceedings of the National Academy of Sciences of the United States of America. 111: E4946-53. PMID 25369933 DOI: 10.1073/Pnas.1407079111 |
0.456 |
|
| 2014 |
McKeown MR, Shaw DL, Fu H, Liu S, Xu X, Marineau JJ, Huang Y, Zhang X, Buckley DL, Kadam A, Zhang Z, Blacklow SC, Qi J, Zhang W, Bradner JE. Biased multicomponent reactions to develop novel bromodomain inhibitors. Journal of Medicinal Chemistry. 57: 9019-27. PMID 25314271 DOI: 10.1021/Jm501120Z |
0.305 |
|
| 2014 |
Arnett KL, Blacklow SC. Analyzing the nuclear complexes of Notch signaling by electrophoretic mobility shift assay. Methods in Molecular Biology (Clifton, N.J.). 1187: 231-45. PMID 25053494 DOI: 10.1007/978-1-4939-1139-4_18 |
0.345 |
|
| 2014 |
Wang H, Zang C, Taing L, Arnett KL, Wong YJ, Pear WS, Blacklow SC, Liu XS, Aster JC. NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers. Proceedings of the National Academy of Sciences of the United States of America. 111: 705-10. PMID 24374627 DOI: 10.1073/pnas.1315023111 |
0.306 |
|
| 2013 |
Blacklow SC. Refining a Jagged edge. Structure (London, England : 1993). 21: 2100-1. PMID 24315457 DOI: 10.1016/J.Str.2013.11.001 |
0.443 |
|
| 2013 |
Andrawes MB, Xu X, Liu H, Ficarro SB, Marto JA, Aster JC, Blacklow SC. Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1. The Journal of Biological Chemistry. 288: 25477-89. PMID 23839946 DOI: 10.1074/Jbc.M113.454850 |
0.472 |
|
| 2013 |
Tiyanont K, Wales TE, Siebel CW, Engen JR, Blacklow SC. Insights into Notch3 activation and inhibition mediated by antibodies directed against its negative regulatory region. Journal of Molecular Biology. 425: 3192-204. PMID 23747483 DOI: 10.1016/J.Jmb.2013.05.025 |
0.419 |
|
| 2013 |
Roti G, Carlton A, Ross KN, Markstein M, Pajcini K, Su AH, Perrimon N, Pear WS, Kung AL, Blacklow SC, Aster JC, Stegmaier K. Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer. Cancer Cell. 23: 390-405. PMID 23434461 DOI: 10.1016/J.Ccr.2013.01.015 |
0.416 |
|
| 2012 |
Aster JC, Blacklow SC. Targeting the Notch pathway: twists and turns on the road to rational therapeutics. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 30: 2418-20. PMID 22585704 DOI: 10.1200/Jco.2012.42.0992 |
0.313 |
|
| 2012 |
O'Donovan DJ, Stokes-Rees I, Nam Y, Blacklow SC, Schröder GF, Brunger AT, Sliz P. A grid-enabled web service for low-resolution crystal structure refinement. Acta Crystallographica. Section D, Biological Crystallography. 68: 261-7. PMID 22349228 DOI: 10.1107/S0907444912001163 |
0.7 |
|
| 2012 |
Choi SH, Wales TE, Nam Y, O'Donovan DJ, Sliz P, Engen JR, Blacklow SC. Conformational locking upon cooperative assembly of notch transcription complexes. Structure (London, England : 1993). 20: 340-9. PMID 22325781 DOI: 10.1016/J.Str.2011.12.011 |
0.769 |
|
| 2012 |
Wang H, Zang C, Taing L, Wong H, Yashiro-Ohtani Y, Blacklow S, Pear WS, Liu XS, Aster JC. Genome-Wide Analysis of NOTCH1, ETS Family Factors, and RUNX1 Binding in Human T Lymphoblastic Leukemia Cells Reveals Distinct Regulatory Elements Blood. 120: 1277-1277. DOI: 10.1182/Blood.V120.21.1277.1277 |
0.438 |
|
| 2011 |
Germar K, Dose M, Konstantinou T, Zhang J, Wang H, Lobry C, Arnett KL, Blacklow SC, Aifantis I, Aster JC, Gounari F. T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling. Proceedings of the National Academy of Sciences of the United States of America. 108: 20060-5. PMID 22109558 DOI: 10.1073/Pnas.1110230108 |
0.358 |
|
| 2011 |
Aster JC, Bodnar N, Xu L, Karnell F, Milholland JM, Maillard I, Histen G, Nam Y, Blacklow SC, Pear WS. Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation. Plos One. 6: e25645. PMID 22022427 DOI: 10.1371/Journal.Pone.0025645 |
0.645 |
|
| 2011 |
Wang NJ, Sanborn Z, Arnett KL, Bayston LJ, Liao W, Proby CM, Leigh IM, Collisson EA, Gordon PB, Jakkula L, Pennypacker S, Zou Y, Sharma M, North JP, Vemula SS, ... ... Blacklow SC, et al. Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma. Proceedings of the National Academy of Sciences of the United States of America. 108: 17761-6. PMID 22006338 DOI: 10.1073/Pnas.1114669108 |
0.456 |
|
| 2011 |
Zhao B, Zou J, Wang H, Johannsen E, Peng CW, Quackenbush J, Mar JC, Morton CC, Freedman ML, Blacklow SC, Aster JC, Bernstein BE, Kieff E. Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth. Proceedings of the National Academy of Sciences of the United States of America. 108: 14902-7. PMID 21746931 DOI: 10.1073/Pnas.1108892108 |
0.33 |
|
| 2011 |
Wang H, Zou J, Zhao B, Johannsen E, Ashworth T, Wong H, Pear WS, Schug J, Blacklow SC, Arnett KL, Bernstein BE, Kieff E, Aster JC. Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells. Proceedings of the National Academy of Sciences of the United States of America. 108: 14908-13. PMID 21737748 DOI: 10.1073/Pnas.1109023108 |
0.405 |
|
| 2011 |
Tiyanont K, Wales TE, Aste-Amezaga M, Aster JC, Engen JR, Blacklow SC. Evidence for increased exposure of the Notch1 metalloprotease cleavage site upon conversion to an activated conformation. Structure (London, England : 1993). 19: 546-54. PMID 21481777 DOI: 10.1016/J.Str.2011.01.016 |
0.418 |
|
| 2011 |
Calderwood MA, Lee S, Holthaus AM, Blacklow SC, Kieff E, Johannsen E. Epstein-Barr virus nuclear protein 3C binds to the N-terminal (NTD) and beta trefoil domains (BTD) of RBP/CSL; only the NTD interaction is essential for lymphoblastoid cell growth. Virology. 414: 19-25. PMID 21440926 DOI: 10.1016/J.Virol.2011.02.018 |
0.446 |
|
| 2011 |
Aster JC, Blacklow SC, Pear WS. Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies. The Journal of Pathology. 223: 262-73. PMID 20967796 DOI: 10.1002/Path.2789 |
0.415 |
|
| 2011 |
Roti G, Carlton A, Ross KN, Markstein M, Pajcini K, Perrimon N, Kung AL, Pear WS, Blacklow SC, Aster JC, Stegmaier K. Intersecting High-Throughput Screens Identifies SERCA As a Target for Modulating NOTCH1 In Hematopoietic Malignancies Blood. 118: 555-555. DOI: 10.1182/Blood.V118.21.555.555 |
0.408 |
|
| 2010 |
Del Bianco C, Vedenko A, Choi SH, Berger MF, Shokri L, Bulyk ML, Blacklow SC. Notch and MAML-1 complexation do not detectably alter the DNA binding specificity of the transcription factor CSL. Plos One. 5: e15034. PMID 21124806 DOI: 10.1371/Journal.Pone.0015034 |
0.409 |
|
| 2010 |
Arnett KL, Hass M, McArthur DG, Ilagan MX, Aster JC, Kopan R, Blacklow SC. Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes. Nature Structural & Molecular Biology. 17: 1312-7. PMID 20972443 DOI: 10.1038/Nsmb.1938 |
0.456 |
|
| 2010 |
Liu H, Chi AW, Arnett KL, Chiang MY, Xu L, Shestova O, Wang H, Li YM, Bhandoola A, Aster JC, Blacklow SC, Pear WS. Notch dimerization is required for leukemogenesis and T-cell development. Genes & Development. 24: 2395-407. PMID 20935071 DOI: 10.1101/Gad.1975210 |
0.445 |
|
| 2010 |
Ashworth TD, Pear WS, Chiang MY, Blacklow SC, Mastio J, Xu L, Kelliher M, Kastner P, Chan S, Aster JC. Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1. Blood. 116: 5455-64. PMID 20852131 DOI: 10.1182/Blood-2010-05-286328 |
0.455 |
|
| 2010 |
Kovall RA, Blacklow SC. Mechanistic insights into Notch receptor signaling from structural and biochemical studies. Current Topics in Developmental Biology. 92: 31-71. PMID 20816392 DOI: 10.1016/S0070-2153(10)92002-4 |
0.434 |
|
| 2010 |
Keeshan K, Bailis W, Dedhia PH, Vega ME, Shestova O, Xu L, Toscano K, Uljon SN, Blacklow SC, Pear WS. Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding. Blood. 116: 4948-57. PMID 20805362 DOI: 10.1182/Blood-2009-10-247361 |
0.444 |
|
| 2010 |
Dedhia PH, Keeshan K, Uljon S, Xu L, Vega ME, Shestova O, Zaks-Zilberman M, Romany C, Blacklow SC, Pear WS. Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia. Blood. 116: 1321-8. PMID 20410507 DOI: 10.1182/Blood-2009-07-229450 |
0.323 |
|
| 2010 |
Aste-Amézaga M, Zhang N, Lineberger JE, Arnold BA, Toner TJ, Gu M, Huang L, Vitelli S, Vo KT, Haytko P, Zhao JZ, Baleydier F, L'Heureux S, Wang H, Gordon WR, ... ... Blacklow SC, et al. Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors. Plos One. 5: e9094. PMID 20161710 DOI: 10.1371/Journal.Pone.0009094 |
0.463 |
|
| 2010 |
Liu H, Chi A, Arnett K, Chiang M, Xu L, Shestova O, Wang H, Bhandoola A, Aster JC, Blacklow SC, Pear WS. Critical Functions for Notch Dimerization In T Cell Transformation. Blood. 116: 3647-3647. DOI: 10.1182/Blood.V116.21.3647.3647 |
0.443 |
|
| 2010 |
Arnett KL, McArthur D, Pear W, Aster J, Blacklow S. Structure and Mechanism of Notch Transcription Complex Dimerization in Gene Regulation Biophysical Journal. 98: 662a. DOI: 10.1016/J.Bpj.2009.12.3634 |
0.43 |
|
| 2009 |
Moellering RE, Cornejo M, Davis TN, Del Bianco C, Aster JC, Blacklow SC, Kung AL, Gilliland DG, Verdine GL, Bradner JE. Direct inhibition of the NOTCH transcription factor complex. Nature. 462: 182-8. PMID 19907488 DOI: 10.1038/Nature08543 |
0.428 |
|
| 2009 |
Gordon WR, Vardar-Ulu D, L'Heureux S, Ashworth T, Malecki MJ, Sanchez-Irizarry C, McArthur DG, Histen G, Mitchell JL, Aster JC, Blacklow SC. Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2. Plos One. 4: e6613. PMID 19701457 DOI: 10.1371/Journal.Pone.0006613 |
0.808 |
|
| 2009 |
Yashiro-Ohtani Y, He Y, Ohtani T, Jones ME, Shestova O, Xu L, Fang TC, Chiang MY, Intlekofer AM, Blacklow SC, Zhuang Y, Pear WS. Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A. Genes & Development. 23: 1665-76. PMID 19605688 DOI: 10.1101/Gad.1793709 |
0.382 |
|
| 2009 |
Gordon WR, Roy M, Vardar-Ulu D, Garfinkel M, Mansour MR, Aster JC, Blacklow SC. Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL. Blood. 113: 4381-90. PMID 19075186 DOI: 10.1182/Blood-2008-08-174748 |
0.521 |
|
| 2009 |
Roti G, Ross KN, Ferrando AA, Blacklow SC, Aster J, Stegmaier K. Expression-Based Screen Identifies the Calcium Channel Antagonist Bepridil as a Notch1 Modulator in T-ALL. Blood. 114: 366-366. DOI: 10.1182/Blood.V114.22.366.366 |
0.417 |
|
| 2008 |
Gordon WR, Arnett KL, Blacklow SC. The molecular logic of Notch signaling--a structural and biochemical perspective. Journal of Cell Science. 121: 3109-19. PMID 18799787 DOI: 10.1242/Jcs.035683 |
0.441 |
|
| 2008 |
Li K, Li Y, Wu W, Gordon WR, Chang DW, Lu M, Scoggin S, Fu T, Vien L, Histen G, Zheng J, Martin-Hollister R, Duensing T, Singh S, Blacklow SC, et al. Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3. The Journal of Biological Chemistry. 283: 8046-54. PMID 18182388 DOI: 10.1074/Jbc.M800170200 |
0.404 |
|
| 2008 |
Estrada K, Fisher C, Blacklow SC. Unfolding of the RAP-D3 helical bundle facilitates dissociation of RAP-receptor complexes. Biochemistry. 47: 1532-9. PMID 18177055 DOI: 10.1021/Bi702076Y |
0.37 |
|
| 2008 |
Del Bianco C, Aster JC, Blacklow SC. Mutational and energetic studies of Notch 1 transcription complexes. Journal of Molecular Biology. 376: 131-40. PMID 18155729 DOI: 10.1016/J.Jmb.2007.11.061 |
0.485 |
|
| 2008 |
Aster JC, Pear WS, Blacklow SC. Notch signaling in leukemia. Annual Review of Pathology. 3: 587-613. PMID 18039126 DOI: 10.1097/00062752-200107000-00010 |
0.435 |
|
| 2008 |
Dedhia P, Keeshan K, Vega M, Uljon S, Xu L, Shestova O, Romany C, Blacklow SC, Pear WS. Trib1 and Trib2 but Not Trib3 Degrade C/EBPá and Induce Acute Myelogenous Leukemia Blood. 112: 2950-2950. DOI: 10.1182/Blood.V112.11.2950.2950 |
0.344 |
|
| 2007 |
Blacklow SC. Versatility in ligand recognition by LDL receptor family proteins: advances and frontiers. Current Opinion in Structural Biology. 17: 419-26. PMID 17870468 DOI: 10.1016/J.Sbi.2007.08.017 |
0.401 |
|
| 2007 |
Fang TC, Yashiro-Ohtani Y, Del Bianco C, Knoblock DM, Blacklow SC, Pear WS. Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity. 27: 100-10. PMID 17658278 DOI: 10.1016/J.Immuni.2007.04.018 |
0.357 |
|
| 2007 |
Koduri V, Blacklow SC. Requirement for natively unstructured regions of mesoderm development candidate 2 in promoting low-density lipoprotein receptor-related protein 6 maturation. Biochemistry. 46: 6570-7. PMID 17488095 DOI: 10.1021/Bi700049G |
0.389 |
|
| 2007 |
Gordon WR, Vardar-Ulu D, Histen G, Sanchez-Irizarry C, Aster JC, Blacklow SC. Structural basis for autoinhibition of Notch. Nature Structural & Molecular Biology. 14: 295-300. PMID 17401372 DOI: 10.1038/Nsmb1227 |
0.822 |
|
| 2007 |
Nam Y, Sliz P, Pear WS, Aster JC, Blacklow SC. Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription. Proceedings of the National Academy of Sciences of the United States of America. 104: 2103-8. PMID 17284587 DOI: 10.1073/Pnas.0611092104 |
0.76 |
|
| 2007 |
Moellering R, Cornejo M, Rocknik J, Hancock M, DelBianco C, Blacklow S, Gilliland G, Verdine G, Bradner J. Direct Inhibition of the Notch Transactivation Complex with Synthetic Constrained Peptides in T-Cell Acute Lymphoblastic Leukemia. Blood. 110: 2819-2819. DOI: 10.1182/Blood.V110.11.2819.2819 |
0.489 |
|
| 2007 |
Gordon WR, Vardar-Ulu D, Histen G, Sanchez-Irizarry C, Aster JC, Blacklow SC. Erratum: Corrigendum: Structural basis for autoinhibition of Notch Nature Structural & Molecular Biology. 14: 455-455. DOI: 10.1038/Nsmb0507-455 |
0.75 |
|
| 2006 |
Chiang MY, Xu ML, Histen G, Shestova O, Roy M, Nam Y, Blacklow SC, Sacks DB, Pear WS, Aster JC. Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1. Molecular and Cellular Biology. 26: 6261-71. PMID 16880534 DOI: 10.1128/Mcb.02478-05 |
0.692 |
|
| 2006 |
Weng AP, Millholland JM, Yashiro-Ohtani Y, Arcangeli ML, Lau A, Wai C, Del Bianco C, Rodriguez CG, Sai H, Tobias J, Li Y, Wolfe MS, Shachaf C, Felsher D, Blacklow SC, et al. c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes & Development. 20: 2096-109. PMID 16847353 DOI: 10.1101/Gad.1450406 |
0.373 |
|
| 2006 |
Malecki MJ, Sanchez-Irizarry C, Mitchell JL, Histen G, Xu ML, Aster JC, Blacklow SC. Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes. Molecular and Cellular Biology. 26: 4642-51. PMID 16738328 DOI: 10.1128/Mcb.01655-05 |
0.817 |
|
| 2006 |
Fisher C, Beglova N, Blacklow SC. Structure of an LDLR-RAP complex reveals a general mode for ligand recognition by lipoprotein receptors. Molecular Cell. 22: 277-83. PMID 16630895 DOI: 10.1016/J.Molcel.2006.02.021 |
0.442 |
|
| 2006 |
Nam Y, Sliz P, Song L, Aster JC, Blacklow SC. Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell. 124: 973-83. PMID 16530044 DOI: 10.1016/J.Cell.2005.12.037 |
0.776 |
|
| 2005 |
Blacklow SC. A new niche for Notch on Deltex? Structure (London, England : 1993). 13: 1579-80. PMID 16271878 DOI: 10.1016/J.Str.2005.10.001 |
0.422 |
|
| 2005 |
Jeon H, Blacklow SC. Structure and physiologic function of the low-density lipoprotein receptor. Annual Review of Biochemistry. 74: 535-62. PMID 15952897 DOI: 10.1146/Annurev.Biochem.74.082803.133354 |
0.318 |
|
| 2005 |
Beglova N, Blacklow SC. The LDL receptor: how acid pulls the trigger. Trends in Biochemical Sciences. 30: 309-17. PMID 15950875 DOI: 10.1016/J.Tibs.2005.03.007 |
0.374 |
|
| 2005 |
Abdul-Aziz D, Fisher C, Beglova N, Blacklow SC. Folding and binding integrity of variants of a prototype ligand-binding module from the LDL receptor possessing multiple alanine substitutions. Biochemistry. 44: 5075-85. PMID 15794645 DOI: 10.1021/Bi047575J |
0.426 |
|
| 2005 |
Stolt PC, Chen Y, Liu P, Bock HH, Blacklow SC, Herz J. Phosphoinositide binding by the disabled-1 PTB domain is necessary for membrane localization and Reelin signal transduction. The Journal of Biological Chemistry. 280: 9671-7. PMID 15632144 DOI: 10.1074/Jbc.M413356200 |
0.809 |
|
| 2005 |
Sanchez-Irizarry C, Malecki M, Lee W, Xu M, Blacklow SC, Aster JC. Functional Analysis of Leukemia-Associated Mutations Involving the Heterodimerization Domain of NOTCH1. Blood. 106: 843-843. DOI: 10.1182/Blood.V106.11.843.843 |
0.819 |
|
| 2004 |
Beglova N, Jeon H, Fisher C, Blacklow SC. Cooperation between fixed and low pH-inducible interfaces controls lipoprotein release by the LDL receptor. Molecular Cell. 16: 281-92. PMID 15494314 DOI: 10.1016/J.Molcel.2004.09.038 |
0.351 |
|
| 2004 |
Beglova N, Jeon H, Fisher C, Blacklow SC. Structural features of the low-density lipoprotein receptor facilitating ligand binding and release. Biochemical Society Transactions. 32: 721-3. PMID 15493997 DOI: 10.1042/Bst0320721 |
0.399 |
|
| 2004 |
Sanchez-Irizarry C, Carpenter AC, Weng AP, Pear WS, Aster JC, Blacklow SC. Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats. Molecular and Cellular Biology. 24: 9265-73. PMID 15485896 DOI: 10.1128/Mcb.24.21.9265-9273.2004 |
0.803 |
|
| 2004 |
Weng AP, Ferrando AA, Lee W, Morris JP, Silverman LB, Sanchez-Irizarry C, Blacklow SC, Look AT, Aster JC. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science (New York, N.Y.). 306: 269-71. PMID 15472075 DOI: 10.1126/Science.1102160 |
0.802 |
|
| 2004 |
Stolt PC, Vardar D, Blacklow SC. The dual-function disabled-1 PTB domain exhibits site independence in binding phosphoinositide and peptide ligands. Biochemistry. 43: 10979-87. PMID 15323557 DOI: 10.1021/Bi049092L |
0.798 |
|
| 2004 |
Blacklow SC. Catching the common cold. Nature Structural & Molecular Biology. 11: 388-90. PMID 15114337 DOI: 10.1038/Nsmb0504-388 |
0.397 |
|
| 2004 |
Boswell EJ, Jeon H, Blacklow SC, Downing AK. Global defects in the expression and function of the low density lipoprotein receptor (LDLR) associated with two familial hypercholesterolemia mutations resulting in misfolding of the LDLR epidermal growth factor-AB pair. The Journal of Biological Chemistry. 279: 30611-21. PMID 15100232 DOI: 10.1074/Jbc.M401412200 |
0.462 |
|
| 2004 |
Fisher C, Abdul-Aziz D, Blacklow SC. A two-module region of the low-density lipoprotein receptor sufficient for formation of complexes with apolipoprotein E ligands. Biochemistry. 43: 1037-44. PMID 14744149 DOI: 10.1021/Bi035529Y |
0.393 |
|
| 2004 |
Weng AP, Ferrando AA, Lee W, Morris JP, Silverman LB, Sanchez-Irizarry C, Blacklow SC, Look T, Aster JC. Gain-of-Function NOTCH1 Mutations Occur Frequently in Human T Cell Acute Lymphoblastic Leukemia. Blood. 104: 4-4. DOI: 10.1182/Blood.V104.11.4.4 |
0.822 |
|
| 2003 |
Kim PW, Sun ZY, Blacklow SC, Wagner G, Eck MJ. A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8. Science (New York, N.Y.). 301: 1725-8. PMID 14500983 DOI: 10.1126/Science.1085643 |
0.303 |
|
| 2003 |
Vardar D, North CL, Sanchez-Irizarry C, Aster JC, Blacklow SC. Nuclear magnetic resonance structure of a prototype Lin12-Notch repeat module from human Notch1. Biochemistry. 42: 7061-7. PMID 12795601 DOI: 10.1021/Bi034156Y |
0.815 |
|
| 2003 |
Stolt PC, Jeon H, Song HK, Herz J, Eck MJ, Blacklow SC. Origins of peptide selectivity and phosphoinositide binding revealed by structures of disabled-1 PTB domain complexes. Structure (London, England : 1993). 11: 569-79. PMID 12737822 DOI: 10.1016/S0969-2126(03)00068-6 |
0.798 |
|
| 2003 |
Nam Y, Weng AP, Aster JC, Blacklow SC. Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex. The Journal of Biological Chemistry. 278: 21232-9. PMID 12644465 DOI: 10.1074/Jbc.M301567200 |
0.665 |
|
| 2003 |
Jeon H, Blacklow SC. An intramolecular spin of the LDL receptor beta propeller. Structure (London, England : 1993). 11: 133-6. PMID 12575931 DOI: 10.1016/S0969-2126(03)00010-8 |
0.32 |
|
| 2003 |
Weng AP, Nam Y, Wolfe MS, Pear WS, Griffin JD, Blacklow SC, Aster JC. Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling. Molecular and Cellular Biology. 23: 655-64. PMID 12509463 DOI: 10.1128/Mcb.23.2.655-664.2003 |
0.641 |
|
| 2002 |
Nam Y, Aster JC, Blacklow SC. Notch signaling as a therapeutic target. Current Opinion in Chemical Biology. 6: 501-9. PMID 12133727 DOI: 10.1016/S1367-5931(02)00346-0 |
0.655 |
|
| 2002 |
Beglova N, Blacklow SC, Takagi J, Springer TA. Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation. Nature Structural Biology. 9: 282-7. PMID 11896403 DOI: 10.1038/Nsb779 |
0.42 |
|
| 2002 |
Stone JR, Maki JL, Blacklow SC, Collins T. The SCAN domain of ZNF174 is a dimer. The Journal of Biological Chemistry. 277: 5448-52. PMID 11741982 DOI: 10.1074/Jbc.M109815200 |
0.39 |
|
| 2001 |
Koduri V, Blacklow SC. Folding determinants of LDL receptor type A modules. Biochemistry. 40: 12801-7. PMID 11669616 DOI: 10.1021/Bi011344K |
0.328 |
|
| 2001 |
Takagi J, Beglova N, Yalamanchili P, Blacklow SC, Springer TA. Definition of EGF-like, closely interacting modules that bear activation epitopes in integrin beta subunits. Proceedings of the National Academy of Sciences of the United States of America. 98: 11175-80. PMID 11572973 DOI: 10.1073/Pnas.201420198 |
0.409 |
|
| 2001 |
Jeon H, Meng W, Takagi J, Eck MJ, Springer TA, Blacklow SC. Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair. Nature Structural Biology. 8: 499-504. PMID 11373616 DOI: 10.1038/88556 |
0.413 |
|
| 2001 |
Adkins HB, Blacklow SC, Young JA. Two functionally distinct forms of a retroviral receptor explain the nonreciprocal receptor interference among subgroups B, D, and E avian leukosis viruses. Journal of Virology. 75: 3520-6. PMID 11264341 DOI: 10.1128/Jvi.75.8.3520-3526.2001 |
0.317 |
|
| 2001 |
Beglova N, North CL, Blacklow SC. Backbone dynamics of a module pair from the ligand-binding domain of the LDL receptor. Biochemistry. 40: 2808-15. PMID 11258891 DOI: 10.1021/Bi0027276 |
0.408 |
|
| 2000 |
Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD. MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. Nature Genetics. 26: 484-9. PMID 11101851 DOI: 10.1038/82644 |
0.501 |
|
| 2000 |
North CL, Blacklow SC. Evidence that familial hypercholesterolemia mutations of the LDL receptor cause limited local misfolding in an LDL-A module pair. Biochemistry. 39: 13127-35. PMID 11052664 DOI: 10.1021/Bi0015156 |
0.404 |
|
| 2000 |
North CL, Blacklow SC. Solution structure of the sixth LDL-A module of the LDL receptor. Biochemistry. 39: 2564-71. PMID 10704205 DOI: 10.1021/Bi992087A |
0.447 |
|
| 2000 |
Rand MD, Grimm LM, Artavanis-Tsakonas S, Patriub V, Blacklow SC, Sklar J, Aster JC. Calcium depletion dissociates and activates heterodimeric notch receptors. Molecular and Cellular Biology. 20: 1825-35. PMID 10669757 DOI: 10.1128/Mcb.20.5.1825-1835.2000 |
0.401 |
|
| 1999 |
Williams AJ, Blacklow SC, Collins T. The zinc finger-associated SCAN box is a conserved oligomerization domain. Molecular and Cellular Biology. 19: 8526-35. PMID 10567577 DOI: 10.1128/Mcb.19.12.8526 |
0.375 |
|
| 1999 |
Aster JC, Simms WB, Zavala-Ruiz Z, Patriub V, North CL, Blacklow SC. The folding and structural integrity of the first LIN-12 module of human Notch1 are calcium-dependent. Biochemistry. 38: 4736-42. PMID 10200161 DOI: 10.1021/Bi982713O |
0.42 |
|
| 1999 |
Zhang Z, Komives EA, Sugio S, Blacklow SC, Narayana N, Xuong NH, Stock AM, Petsko GA, Ringe D. The role of water in the catalytic efficiency of triosephosphate isomerase. Biochemistry. 38: 4389-97. PMID 10194358 DOI: 10.1021/Bi9826759 |
0.596 |
|
| 1999 |
North CL, Blacklow SC. Structural independence of ligand-binding modules five and six of the LDL receptor. Biochemistry. 38: 3926-35. PMID 10194304 DOI: 10.1021/Bi9821622 |
0.42 |
|
| 1997 |
Fass D, Blacklow S, Kim PS, Berger JM. Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module. Nature. 388: 691-3. PMID 9262405 DOI: 10.1038/41798 |
0.566 |
|
| 1996 |
Blacklow SC, Kim PS. Protein folding and calcium binding defects arising from familial hypercholesterolemia mutations of the LDL receptor. Nature Structural Biology. 3: 758-62. PMID 8784348 DOI: 10.1038/Nsb0996-758 |
0.557 |
|
| 1995 |
Lu M, Blacklow SC, Kim PS. A trimeric structural domain of the HIV-1 transmembrane glycoprotein. Nature Structural Biology. 2: 1075-82. PMID 8846219 DOI: 10.1038/Nsb1295-1075 |
0.466 |
|
| 1995 |
Blacklow SC, Lu M, Kim PS. A trimeric subdomain of the simian immunodeficiency virus envelope glycoprotein. Biochemistry. 34: 14955-62. PMID 7578108 DOI: 10.1021/Bi00046A001 |
0.481 |
|
| 1991 |
Blacklow SC, Liu KD, Knowles JR. Stepwise improvements in catalytic effectiveness: independence and interdependence in combinations of point mutations of a sluggish triosephosphate isomerase. Biochemistry. 30: 8470-6. PMID 1883832 DOI: 10.1021/Bi00098A026 |
0.56 |
|
| 1990 |
Blacklow SC, Knowles JR. How can a catalytic lesion be offset? The energetics of two pseudorevertant triosephosphate isomerases. Biochemistry. 29: 4099-108. PMID 2361134 DOI: 10.1021/Bi00469A012 |
0.538 |
|
| 1990 |
Hermes JD, Blacklow SC, Knowles JR. Searching sequence space by definably random mutagenesis: improving the catalytic potency of an enzyme. Proceedings of the National Academy of Sciences of the United States of America. 87: 696-700. PMID 1967829 DOI: 10.1073/Pnas.87.2.696 |
0.535 |
|
| 1989 |
Hermes JD, Parekh SM, Blacklow SC, Köster H, Knowles JR. A reliable method for random mutagenesis: the generation of mutant libraries using spiked oligodeoxyribonucleotide primers. Gene. 84: 143-51. PMID 2691332 DOI: 10.1016/0378-1119(89)90148-0 |
0.529 |
|
| 1988 |
Blacklow SC, Raines RT, Lim WA, Zamore PD, Knowles JR. Triosephosphate isomerase catalysis is diffusion controlled. Appendix: Analysis of triose phosphate equilibria in aqueous solution by 31P NMR. Biochemistry. 27: 1158-67. PMID 3365378 DOI: 10.1021/Bi00404A013 |
0.611 |
|
| 1987 |
Hermes JD, Blacklow SC, Knowles JR. The development of enzyme catalytic efficiency: an experimental approach. Cold Spring Harbor Symposia On Quantitative Biology. 52: 597-602. PMID 3454280 DOI: 10.1101/Sqb.1987.052.01.068 |
0.479 |
|
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