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Mark P. Brynildsen - Publications

Affiliations: 
Chemical and Biological Engineering Princeton University, Princeton, NJ 
Area:
host-pathogen interactions, bacterial persistence, and biofilms
Website:
http://www.princeton.edu/cbe/people/faculty/brynildsen/
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52 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Chou WK, Vaikunthan M, Schröder HV, Link AJ, Kim H, Brynildsen MP. Synergy Screening Identifies a Compound That Selectively Enhances the Antibacterial Activity of Nitric Oxide. Frontiers in Bioengineering and Biotechnology. 8: 1001. PMID 32984281 DOI: 10.3389/Fbioe.2020.01001  0.354
2020 Sivaloganathan DM, Wan X, Brynildsen MP. Quantifying Nitric Oxide Flux Distributions. Methods in Molecular Biology (Clifton, N.J.). 2088: 161-188. PMID 31893374 DOI: 10.1007/978-1-0716-0159-4_8  0.343
2019 Aedo SJ, Orman MA, Brynildsen MP. Stationary phase persister formation in Escherichia coli can be suppressed by piperacillin and PBP3 inhibition. Bmc Microbiology. 19: 140. PMID 31234796 DOI: 10.1186/S12866-019-1506-7  0.313
2019 Adolfsen KJ, Chou WK, Brynildsen MP. Transcriptional regulation contributes to prioritized detoxification of hydrogen peroxide over nitric oxide. Journal of Bacteriology. PMID 31061166 DOI: 10.1128/Jb.00081-19  0.361
2019 Balaban NQ, Helaine S, Lewis K, Ackermann M, Aldridge B, Andersson DI, Brynildsen MP, Bumann D, Camilli A, Collins JJ, Dehio C, Fortune S, Ghigo JM, Hardt WD, Harms A, et al. Publisher Correction: Definitions and guidelines for research on antibiotic persistence. Nature Reviews. Microbiology. PMID 31036919 DOI: 10.1038/S41579-019-0207-4  0.401
2019 Balaban NQ, Helaine S, Lewis K, Ackermann M, Aldridge B, Andersson DI, Brynildsen MP, Bumann D, Camilli A, Collins JJ, Dehio C, Fortune S, Ghigo JM, Hardt WD, Harms A, et al. Definitions and guidelines for research on antibiotic persistence. Nature Reviews. Microbiology. PMID 30980069 DOI: 10.1038/S41579-019-0196-3  0.492
2019 Barrett TC, Mok WWK, Murawski AM, Brynildsen MP. Enhanced antibiotic resistance development from fluoroquinolone persisters after a single exposure to antibiotic. Nature Communications. 10: 1177. PMID 30862812 DOI: 10.1038/S41467-019-09058-4  0.349
2019 Aedo SJ, Ma HR, Brynildsen MP. Checks and Balances with Use of the Keio Collection for Phenotype Testing. Methods in Molecular Biology (Clifton, N.J.). 1927: 125-138. PMID 30788789 DOI: 10.1007/978-1-4939-9142-6_9  0.315
2018 Chou WK, Brynildsen MP. Loss of DksA leads to multi-faceted impairment of nitric oxide detoxification by Escherichia coli. Free Radical Biology & Medicine. PMID 30366060 DOI: 10.1016/J.Freeradbiomed.2018.10.435  0.392
2018 Brynildsen MP. Nitric Oxide Stress as a Metabolic Flux. Advances in Microbial Physiology. 73: 63-76. PMID 30262110 DOI: 10.1016/Bs.Ampbs.2018.06.003  0.407
2018 Mok WWK, Brynildsen MP. Timing of DNA damage responses impacts persistence to fluoroquinolones. Proceedings of the National Academy of Sciences of the United States of America. PMID 29915065 DOI: 10.1073/Pnas.1804218115  0.319
2017 Sacco SA, Adolfsen KJ, Brynildsen MP. An integrated network analysis identifies how ArcAB enables metabolic oscillations in the nitric oxide detoxification network of Escherichia coli. Biotechnology Journal. PMID 28449226 DOI: 10.1002/Biot.201600570  0.381
2017 Barrett TC, Mok WWK, Brynildsen MP. Biased inheritance protects older bacteria from harm. Science (New York, N.Y.). 356: 247-248. PMID 28428383 DOI: 10.1126/Science.Aan0348  0.323
2017 Robinson JL, Jaslove JM, Murawski AM, Fazen CH, Brynildsen MP. An integrated network analysis reveals that nitric oxide reductase prevents metabolic cycling of nitric oxide by Pseudomonas aeruginosa. Metabolic Engineering. PMID 28363762 DOI: 10.1016/J.Ymben.2017.03.006  0.379
2016 Robinson JL, Brynildsen MP. Construction and Experimental Validation of a Quantitative Kinetic Model of Nitric Oxide Stress in Enterohemorrhagic Escherichia coli O157:H7. Bioengineering (Basel, Switzerland). 3. PMID 28952571 DOI: 10.3390/Bioengineering3010009  0.365
2016 Gowers GF, Robinson JL, Brynildsen MP. Starved Escherichia coli preserve reducing power under nitric oxide stress. Biochemical and Biophysical Research Communications. PMID 27207837 DOI: 10.1016/J.Bbrc.2016.05.082  0.358
2016 Henry TC, Brynildsen MP. Development of Persister-FACSeq: a method to massively parallelize quantification of persister physiology and its heterogeneity. Scientific Reports. 6: 25100. PMID 27142337 DOI: 10.1038/Srep25100  0.376
2016 Henry TC, Brynildsen MP. Quantifying Current Events Identifies a Novel Endurance Regulator. Trends in Microbiology. PMID 26954590 DOI: 10.1016/J.Tim.2016.02.014  0.345
2016 Robinson JL, Brynildsen MP. Discovery and dissection of metabolic oscillations in the microaerobic nitric oxide response network of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. PMID 26951670 DOI: 10.1073/Pnas.1521354113  0.386
2016 Orman MA, Brynildsen MP. Persister formation in Escherichia coli can be inhibited by treatment with nitric oxide. Free Radical Biology & Medicine. PMID 26849946 DOI: 10.1016/J.Freeradbiomed.2016.02.003  0.38
2016 Orman MA, Henry TC, DeCoste CJ, Brynildsen MP. Analyzing Persister Physiology with Fluorescence-Activated Cell Sorting. Methods in Molecular Biology (Clifton, N.J.). 1333: 83-100. PMID 26468102 DOI: 10.1007/978-1-4939-2854-5_8  0.354
2016 Chou WK, Brynildsen MP. A biochemical engineering view of the quest for immune-potentiating anti-infectives Current Opinion in Chemical Engineering. 14: 82-92. DOI: 10.1016/J.Coche.2016.08.018  0.375
2015 Sandvik EL, Fazen CH, Henry TC, Mok WW, Brynildsen MP. Non-Monotonic Survival of Staphylococcus aureus with Respect to Ciprofloxacin Concentration Arises from Prophage-Dependent Killing of Persisters. Pharmaceuticals (Basel, Switzerland). 8: 778-792. PMID 26593926 DOI: 10.3390/Ph8040778  0.332
2015 Mok WW, Park JO, Rabinowitz JD, Brynildsen MP. RNA Futile Cycling in Model Persisters Derived from MazF Accumulation. Mbio. 6. PMID 26578677 DOI: 10.1128/Mbio.01588-15  0.387
2015 Adolfsen KJ, Brynildsen MP. A Kinetic Platform to Determine the Fate of Hydrogen Peroxide in Escherichia coli. Plos Computational Biology. 11: e1004562. PMID 26545295 DOI: 10.1371/Journal.Pcbi.1004562  0.349
2015 Völzing KG, Brynildsen MP. Stationary-Phase Persisters to Ofloxacin Sustain DNA Damage and Require Repair Systems Only during Recovery. Mbio. 6: e00731-15. PMID 26330511 DOI: 10.1128/Mbio.00731-15  0.38
2015 Amato SM, Brynildsen MP. Persister Heterogeneity Arising from a Single Metabolic Stress. Current Biology : Cb. 25: 2090-8. PMID 26255847 DOI: 10.1016/J.Cub.2015.06.034  0.409
2015 Orman MA, Brynildsen MP. Inhibition of stationary phase respiration impairs persister formation in E. coli. Nature Communications. 6: 7983. PMID 26246187 DOI: 10.1038/Ncomms8983  0.394
2015 Robinson JL, Brynildsen MP. An ensemble-guided approach identifies ClpP as a major regulator of transcript levels in nitric oxide-stressed Escherichia coli. Metabolic Engineering. PMID 26112956 DOI: 10.1016/J.Ymben.2015.06.005  0.387
2015 Adolfsen KJ, Brynildsen MP. Futile cycling increases sensitivity toward oxidative stress in Escherichia coli. Metabolic Engineering. 29: 26-35. PMID 25732623 DOI: 10.1016/J.Ymben.2015.02.006  0.381
2015 Mok WW, Orman MA, Brynildsen MP. Impacts of global transcriptional regulators on persister metabolism. Antimicrobial Agents and Chemotherapy. 59: 2713-9. PMID 25712354 DOI: 10.1128/Aac.04908-14  0.406
2015 Orman MA, Mok WW, Brynildsen MP. Aminoglycoside-enabled elucidation of bacterial persister metabolism. Current Protocols in Microbiology. 36: 17.9.1-17.9.14. PMID 25641098 DOI: 10.1002/9780471729259.Mc1709S36  0.425
2014 Robinson JL, Adolfsen KJ, Brynildsen MP. Deciphering nitric oxide stress in bacteria with quantitative modeling. Current Opinion in Microbiology. 19: 16-24. PMID 24983704 DOI: 10.1016/J.Mib.2014.05.018  0.339
2014 Amato SM, Brynildsen MP. Nutrient transitions are a source of persisters in Escherichia coli biofilms. Plos One. 9: e93110. PMID 24667358 DOI: 10.1371/Journal.Pone.0093110  0.399
2014 Amato SM, Fazen CH, Henry TC, Mok WW, Orman MA, Sandvik EL, Volzing KG, Brynildsen MP. The role of metabolism in bacterial persistence. Frontiers in Microbiology. 5: 70. PMID 24624123 DOI: 10.3389/Fmicb.2014.00070  0.404
2014 Robinson JL, Miller RV, Brynildsen MP. Model-driven identication of dosing regimens that maximize the antimicrobial activity of nitric oxide Metabolic Engineering Communications. 1: 12-18. DOI: 10.1016/J.Meteno.2014.08.001  0.317
2013 Orman MA, Brynildsen MP. Establishment of a method to rapidly assay bacterial persister metabolism. Antimicrobial Agents and Chemotherapy. 57: 4398-409. PMID 23817376 DOI: 10.1128/Aac.00372-13  0.402
2013 Amato SM, Orman MA, Brynildsen MP. Metabolic control of persister formation in Escherichia coli. Molecular Cell. 50: 475-87. PMID 23665232 DOI: 10.1016/J.Molcel.2013.04.002  0.409
2013 Robinson JL, Brynildsen MP. A kinetic platform to determine the fate of nitric oxide in Escherichia coli. Plos Computational Biology. 9: e1003049. PMID 23658508 DOI: 10.1371/Journal.Pcbi.1003049  0.409
2013 Orman MA, Brynildsen MP. Dormancy is not necessary or sufficient for bacterial persistence. Antimicrobial Agents and Chemotherapy. 57: 3230-9. PMID 23629720 DOI: 10.1128/Aac.00243-13  0.399
2013 Brynildsen MP, Winkler JA, Spina CS, MacDonald IC, Collins JJ. Potentiating antibacterial activity by predictably enhancing endogenous microbial ROS production. Nature Biotechnology. 31: 160-5. PMID 23292609 DOI: 10.1038/Nbt.2458  0.752
2011 Allison KR, Brynildsen MP, Collins JJ. Heterogeneous bacterial persisters and engineering approaches to eliminate them. Current Opinion in Microbiology. 14: 593-8. PMID 21937262 DOI: 10.1016/J.Mib.2011.09.002  0.697
2011 Allison KR, Brynildsen MP, Collins JJ. Metabolite-enabled eradication of bacterial persisters by aminoglycosides. Nature. 473: 216-20. PMID 21562562 DOI: 10.1038/Nature10069  0.715
2009 Brynildsen MP, Liao JC. An integrated network approach identifies the isobutanol response network of Escherichia coli. Molecular Systems Biology. 5: 277. PMID 19536200 DOI: 10.1038/Msb.2009.34  0.568
2009 Brynildsen MP, Collins JJ. Systems biology makes it personal. Molecular Cell. 34: 137-8. PMID 19394290 DOI: 10.1016/J.Molcel.2009.04.004  0.449
2008 Atsumi S, Cann AF, Connor MR, Shen CR, Smith KM, Brynildsen MP, Chou KJ, Hanai T, Liao JC. Metabolic engineering of Escherichia coli for 1-butanol production. Metabolic Engineering. 10: 305-11. PMID 17942358 DOI: 10.1016/J.Ymben.2007.08.003  0.597
2007 Brynildsen MP, Wu TY, Jang SS, Liao JC. Biological network mapping and source signal deduction. Bioinformatics (Oxford, England). 23: 1783-91. PMID 17495996 DOI: 10.1093/Bioinformatics/Btm246  0.526
2006 Brynildsen MP, Tran LM, Liao JC. A Gibbs sampler for the identification of gene expression and network connectivity consistency. Bioinformatics (Oxford, England). 22: 3040-6. PMID 17060361 DOI: 10.1093/Bioinformatics/Btl541  0.62
2006 Brynildsen MP, Tran LM, Liao JC. Versatility and connectivity efficiency of bipartite transcription networks. Biophysical Journal. 91: 2749-59. PMID 16815895 DOI: 10.1529/Biophysj.106.082560  0.628
2005 Brynildsen MP, Wong WW, Liao JC. Transcriptional regulation and metabolism. Biochemical Society Transactions. 33: 1423-6. PMID 16246136 DOI: 10.1042/Bst20051423  0.564
2005 Yang YL, Suen J, Brynildsen MP, Galbraith SJ, Liao JC. Inferring yeast cell cycle regulators and interactions using transcription factor activities. Bmc Genomics. 6: 90. PMID 15949038 DOI: 10.1186/1471-2164-6-90  0.475
2005 Tran LM, Brynildsen MP, Kao KC, Suen JK, Liao JC. gNCA: a framework for determining transcription factor activity based on transcriptome: identifiability and numerical implementation. Metabolic Engineering. 7: 128-41. PMID 15781421 DOI: 10.1016/J.Ymben.2004.12.001  0.701
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