Year |
Citation |
Score |
2023 |
Derdau V, Elmore CS, Hartung T, McKillican B, Mejuch T, Rosenbaum C, Wiebe C. The Future of (radio)-labeled Compounds in Research and Development of the Life Science Industry. Angewandte Chemie (International Ed. in English). e202306019. PMID 37610759 DOI: 10.1002/anie.202306019 |
0.321 |
|
2023 |
Ton SJ, Ravn AK, Hoffmann DV, Day CS, Kingston L, Elmore CS, Skrydstrup T. Rapid Access to Carbon-Isotope-Labeled Alkyl and Aryl Carboxylates Applying Palladacarboxylates. Jacs Au. 3: 756-761. PMID 37006775 DOI: 10.1021/jacsau.2c00708 |
0.646 |
|
2023 |
Passannante R, Gómez-Vallejo V, Sagartzazu-Aizpurua M, Vignau Arsuaga L, Marco-Moreno P, Aldanondo G, Vallejo-Illarramendi A, Aguiar P, Cossío U, Martín A, Bergare J, Kingston L, Elmore CS, Morcillo MA, Ferrón P, et al. Pharmacokinetic Evaluation of New Drugs Using a Multi-Labelling Approach and PET Imaging: Application to a Drug Candidate with Potential Application in Neuromuscular Disorders. Biomedicines. 11. PMID 36830793 DOI: 10.3390/biomedicines11020253 |
0.324 |
|
2022 |
Sardana M, Breuil L, Goutal S, Goislard M, Kondrashov M, Marchal E, Besson FL, Dugave C, Wrigley G, Jonson AC, Kuhnast B, Schou M, Tournier N, Elmore CS, Caillé F. Isotopic Radiolabeling of Crizotinib with Fluorine-18 for In Vivo Pet Imaging. Pharmaceuticals (Basel, Switzerland). 15. PMID 36559018 DOI: 10.3390/ph15121568 |
0.285 |
|
2022 |
Zügner E, Yang HC, Kotzbeck P, Boulgaropoulos B, Sourij H, Hagvall S, Elmore CS, Esterline R, Moosmang S, Oscarsson J, Pieber TR, Peng XR, Magnes C. Differential In Vitro Effects of SGLT2 Inhibitors on Mitochondrial Oxidative Phosphorylation, Glucose Uptake and Cell Metabolism. International Journal of Molecular Sciences. 23. PMID 35887308 DOI: 10.3390/ijms23147966 |
0.241 |
|
2022 |
Dahl K, Johnström P, Forsberg-Morén A, Gustafsson B, Miranda-Azpiazu P, Khani Y, Halldin C, Farde L, Elmore CS, Schou M. Synthesis and Preclinical Evaluation of [C]AZ11895530 for PET Imaging of the Serotonin 1A Receptor. Acs Chemical Neuroscience. PMID 35802379 DOI: 10.1021/acschemneuro.2c00205 |
0.315 |
|
2022 |
Feeney OM, Ardipradja K, Noi KF, Mehta D, De Rose R, Yuen D, Johnston APR, Kingston L, Ericsson C, Elmore CS, Hufton R, Owen DJ, Ashford MB, Porter CJH. Subcutaneous delivery of a dendrimer-BH3 mimetic improves lymphatic uptake and survival in lymphoma. Journal of Controlled Release : Official Journal of the Controlled Release Society. 348: 420-430. PMID 35636618 DOI: 10.1016/j.jconrel.2022.05.041 |
0.233 |
|
2022 |
Bertarello A, Berruyer P, Artelsmair M, Elmore CS, Heydarkhan-Hagvall S, Schade M, Chiarparin E, Schantz S, Emsley L. In-Cell Quantification of Drugs by Magic-Angle Spinning Dynamic Nuclear Polarization NMR. Journal of the American Chemical Society. PMID 35385274 DOI: 10.1021/jacs.1c12442 |
0.261 |
|
2022 |
Sardana M, Mühlfenzl KS, Wenker STM, Åkesson C, Hayes MA, Elmore CS, Pithani S. Exploring the enzyme-catalyzed synthesis of isotope labeled cyclopropanes. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 34997781 DOI: 10.1002/jlcr.3962 |
0.353 |
|
2021 |
Bertarello A, Berruyer P, Skantze U, Sardana S, Sardana M, Elmore CS, Schade M, Chiarparin E, Schantz S, Emsley L. Quantification of magic angle spinning dynamic nuclear polarization NMR spectra. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 329: 107030. PMID 34245958 DOI: 10.1016/j.jmr.2021.107030 |
0.232 |
|
2021 |
Feng M, De Oliveira J, Sallustrau A, Destro G, Thuéry P, Roy S, Cantat T, Elmore CS, Blankenstein J, Taran F, Audisio D. Direct Carbon Isotope Exchange of Pharmaceuticals via Reversible Decyanation. Journal of the American Chemical Society. PMID 33825486 DOI: 10.1021/jacs.1c01923 |
0.343 |
|
2021 |
Sebastiani F, Yanez Arteta M, Lerche M, Porcar L, Lang C, Bragg RA, Elmore CS, Krishnamurthy VR, Russell RA, Darwish T, Pichler H, Waldie S, Moulin M, Haertlein M, Forsyth VT, et al. Apolipoprotein E Binding Drives Structural and Compositional Rearrangement of mRNA-Containing Lipid Nanoparticles. Acs Nano. PMID 33754708 DOI: 10.1021/acsnano.0c10064 |
0.218 |
|
2020 |
Kingston L, Gu C, Guo J, Swallow S, Elmore CS. The impact of radiochemistry in drug projects: The use of C-14 labeled in the AZD8529, AZD7325 and AZD6280 projects. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 33326121 DOI: 10.1002/jlcr.3902 |
0.343 |
|
2020 |
Miranda-Azpiazu P, Svedberg M, Higuchi M, Ono M, Jia Z, Sunnemark D, Elmore CS, Schou M, Varrone A. Identification and in vitro characterization of C05-01, a PPB3 derivative with improved affinity for alpha-synuclein. Brain Research. 1749: 147131. PMID 32956648 DOI: 10.1016/J.Brainres.2020.147131 |
0.312 |
|
2020 |
Colombano A, Dall'Angelo S, Kingston L, Grönberg G, Correia C, Passannante R, Baz Z, Morcillo MÁ, Elmore CS, Llop J, Zanda M. 4,4,16-Trifluoropalmitate: Design, Synthesis, Tritiation, Radiofluorination and Preclinical PET Imaging Studies on Myocardial Fatty Acid Oxidation. Chemmedchem. PMID 32856369 DOI: 10.1002/cmdc.202000610 |
0.286 |
|
2020 |
Bergare J, Nixon N, Newsome J, Thunberg L, Elmore CS. Synthesis of C-14 labeled Rac-(3R,2S)-Glycopyrronium Bromide. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 32476159 DOI: 10.1002/jlcr.3864 |
0.405 |
|
2020 |
Bergare J, Kingston L, Guly DJ, Dolan J, Lewis RJ, Elmore CS. The synthesis of one H-2 labeled and two H-3 labeled leukotriene C4 synthase inhibitors. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 32441366 DOI: 10.1002/Jlcr.3862 |
0.438 |
|
2020 |
Destro G, Horkka K, Loreau O, Buisson DA, Kingston L, Del Vecchio A, Schou M, Elmore C, Taran F, Cantat T, Audisio D. Transition-Metal-Free Carbon Isotope Exchange of Phenyl Acetic Acids. Angewandte Chemie (International Ed. in English). PMID 32348625 DOI: 10.1002/Anie.202002341 |
0.342 |
|
2020 |
Skrydstrup T, Donslund A, Pedersen S, Gaardbo C, Kingston L, Elmore C, Neumann K. Direct Access to Isotopically Labeled Aliphatic Ketones Mediated by Nickel(I) Activation. Angewandte Chemie (International Ed. in English). PMID 32017346 DOI: 10.1002/Anie.201916391 |
0.327 |
|
2019 |
Sardana M, Bergman J, Ericsson C, Kingston LP, Schou M, Dugave C, Audisio D, Elmore CS. Visible-Light-Enabled Aminocarbonylation of Unactivated Alkyl Iodides with Stoichiometric Carbon Monoxide for Application on Late-Stage Carbon Isotope Labeling. The Journal of Organic Chemistry. PMID 31769679 DOI: 10.1021/acs.joc.9b02575 |
0.324 |
|
2019 |
Lindberg A, Arakawa R, Nogami T, Nag S, Schou M, Elmore CS, Farde L, Pike VW, Halldin C. Potential for imaging the high-affinity state of the 5-HT receptor: a comparison of three PET radioligands with differing intrinsic activity. Ejnmmi Research. 9: 100. PMID 31754940 DOI: 10.1186/S13550-019-0570-1 |
0.25 |
|
2019 |
Lindberg A, Nag S, Schou M, Arakawa R, Nogami T, Moein MM, Elmore CS, Pike VW, Halldin C. Development of a F-labeled PET radioligand for imaging 5-HT receptors: [F]AZ10419096. Nuclear Medicine and Biology. 78: 11-16. PMID 31678782 DOI: 10.1016/J.Nucmedbio.2019.10.003 |
0.291 |
|
2019 |
Varnäs K, Cselényi Z, Arakawa R, Nag S, Stepanov V, Moein MM, Johnström P, Kingston L, Elmore CS, Halldin C, Farde L. The pro-psychotic metabotropic glutamate receptor compounds fenobam and AZD9272 share binding sites with monoamine oxidase-B inhibitors in humans. Neuropharmacology. 107809. PMID 31589885 DOI: 10.1016/J.Neuropharm.2019.107809 |
0.287 |
|
2019 |
Booker-Milburn K, Betts HM, O'Connor RA, Christian JA, Vinayakamoorthy V, Foweraker K, Pascoe AC, Perkins AC, Artelsmair M, Azpiazu PM, Kingston L, Bergare J, Schou M, Varrone A, Elmore CS, et al. Abstracts. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 31307121 DOI: 10.1002/jlcr.3784 |
0.257 |
|
2019 |
Kingston LP, Hickey MJ, Elmore CS. THE SYNTHESIS OF ISOTOPOLOGUES OF AZD7307. A SELECTIVE β -ADRENORECEPTOR AGONIST. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 31215663 DOI: 10.1002/jlcr.3778 |
0.243 |
|
2019 |
Czeskis B, Elmore CS, Haight A, Hesk D, Maxwell BD, Miller SA, Raglione T, Schildknegt K, Traverse JF, Wang P. Deuterated Active Pharmaceutical Ingredients: A Science Based Proposal for Synthesis, Analysis, and Control. Part 1: Framing the Problem. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 31034626 DOI: 10.1002/jlcr.3743 |
0.34 |
|
2019 |
Artelsmair M, Miranda-Azpiazu P, Kingston L, Bergare J, Schou M, Varrone A, Elmore CS. Synthesis, H-labelling and in vitro evaluation of a substituted dipiperidine alcohol as a potential ligand for chemokine receptor 2. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 30937946 DOI: 10.1002/Jlcr.3731 |
0.316 |
|
2019 |
Lindberg A, Lu S, Nag S, Schou M, Liow JS, Zoghbi SS, Frankland MP, Gladding RL, Morse CL, Takano A, Amini N, Elmore CS, Lee YS, Innis RB, Halldin C, et al. Synthesis and evaluation of two new candidate high-affinity full agonist PET radioligands for imaging 5-HT receptors. Nuclear Medicine and Biology. 70: 1-13. PMID 30811975 DOI: 10.1016/J.Nucmedbio.2019.01.005 |
0.276 |
|
2019 |
Hickey MJ, Lindqvist J, Ha YH, Andersson H, Elmore CS. Synthesis of Di-docosahexaenoyl (C22:6)-bis (monoacyl-glycerol) phosphate in unlabeled and C-13 labeled forms for use as a biomarker of drug induced phospholipidosis. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 30793359 DOI: 10.1002/jlcr.3714 |
0.396 |
|
2019 |
Horkka K, Dahl K, Bergare J, Elmore CS, Halldin C, Schou M. Rapid and Efficient Synthesis of 11
C-Labeled Benzimidazolones Using [11
C]Carbon Dioxide Chemistryselect. 4: 1846-1849. DOI: 10.1002/SLCT.201803561 |
0.353 |
|
2018 |
Testa A, Dall'Angelo S, Mingarelli M, Augello A, Schweiger L, Welch A, Elmore CS, Dawson D, Sharma P, Zanda M. Preclinical Evaluation of [F]LCATD as a PET Tracer to Study Drug-Drug Interactions Caused by Inhibition of Hepatic Transporters. Contrast Media & Molecular Imaging. 2018: 3064751. PMID 30154685 DOI: 10.1155/2018/3064751 |
0.253 |
|
2018 |
Cairns AG, Vazquez-Romero A, Mahdi-Moein M, Åden J, Elmore CS, Takano A, Arakawa R, Varrone A, Almqvist F, Schou M. Increased brain exposure of an alpha-synuclein fibrillization modulator by utilization of an activated ester pro-drug strategy. Acs Chemical Neuroscience. PMID 29901990 DOI: 10.1021/Acschemneuro.8B00236 |
0.331 |
|
2018 |
Bragg RA, Sardana M, Artelsmair M, Elmore CS. New Trends and Applications in Carboxylation for Isotope Chemistry. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 29740851 DOI: 10.1002/jlcr.3633 |
0.331 |
|
2018 |
O'Brien DE, Shaw DM, Cho HP, Cross AJ, Wesolowski SS, Felts AS, Bergare J, Elmore CS, Lindsley CW, Niswender CM, Conn PJ. Differential Pharmacology and Binding of mGlu2 Receptor Allosteric Modulators. Molecular Pharmacology. PMID 29545267 DOI: 10.1124/Mol.117.110114 |
0.242 |
|
2018 |
Artelsmair M, Gu C, Lewis RJ, Elmore CS. Synthesis of C-14 Labeled GABAA α2/α3 Selective Partial Agonists and the Investigation of Late-Occurring and Long-Circulating Metabolites of GABAA Receptor Modulator AZD7325. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 29314165 DOI: 10.1002/Jlcr.3602 |
0.313 |
|
2018 |
Gu C, Artelsmair M, Elmore CS, Lewis RJ, Davis P, Hall JE, Dembofsky BT, Christoph G, Smith MA, Chapdelaine M, Sunzel M. Late-occurring and long-circulating metabolites of GABAAα2,3 receptor modulator AZD7325 involving metabolic cyclization and aromatization: relevance to MIST analysis and application for patient compliance. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 29311137 DOI: 10.1124/Dmd.117.078873 |
0.267 |
|
2018 |
Aboagye E, Aigbirhio F, Allott L, Anderson E, Artelsmair M, Audisio D, Audisio J, Bragg R, Brindle K, Bulat F, Bürli R, Carroll L, Chapdelaine M, Collins S, Cortezon-Tamarit F, ... ... Elmore C, et al. Abstracts of the 26th international isotope society (UK group) symposium: Synthesis & applications of labelled compounds 2017 Journal of Labelled Compounds and Radiopharmaceuticals. 61: 1115-1130. DOI: 10.1002/jlcr.3641 |
0.405 |
|
2017 |
Lindberg A, Nag S, Schou M, Takano A, Matsumoto J, Amini N, Elmore CS, Farde L, Pike VW, Halldin C. [(11)C]AZ10419096 - a full antagonist PET radioligand for imaging brain 5-HT1B receptors. Nuclear Medicine and Biology. 54: 34-40. PMID 28950161 DOI: 10.1016/J.Nucmedbio.2017.07.007 |
0.277 |
|
2017 |
Lin SF, Bois F, Holden D, Nabulsi N, Pracitto R, Gao H, Kapinos M, Teng JK, Shirali A, Ropchan J, Carson RE, Elmore CS, Vasdev N, Huang Y. The Search for a Subtype-Selective PET Imaging Agent for the GABAA Receptor Complex: Evaluation of the Radiotracer [(11)C]ADO in Nonhuman Primates. Molecular Imaging. 16: 1536012117731258. PMID 28929924 DOI: 10.1177/1536012117731258 |
0.31 |
|
2017 |
Kingston L, Bergare J, Lönn H, Ericsson C, Grönberg G, Chen S, Elmore CS. Synthesis of Two C-14 labeled Cathepsin C Inhibitors; the Use of a Cyanide to Displace a Benzotriazole. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 28324911 DOI: 10.1002/jlcr.3502 |
0.403 |
|
2017 |
Hayes MA, Roberts I, Grönberg G, Lv K, Lin B, Bergare J, Elmore CS. Synthesis of 1β-hydroxydeoxycholic acid in H-2 and unlabeled forms. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 28183147 DOI: 10.1002/jlcr.3495 |
0.385 |
|
2017 |
Ellis-Sawyer K, Bragg RA, Bushby N, Elmore CS, Hickey MJ. Isotope Labelling by Reduction of Nitriles: Application to the Synthesis of Isotopologues of Tolmetin and Celecoxib. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 28130854 DOI: 10.1002/jlcr.3492 |
0.44 |
|
2017 |
Zanda M, Vugts DJ, Caveliers V, Bj'rsvik H, Mareque-Rivas J, Jacobs A, Passchier J, Elmore C. PET3D – PET Imaging in Drug Design and Development – H2020 Impact. 2017: 42-45. DOI: 10.21820/23987073.2017.8.42 |
0.248 |
|
2016 |
Testa A, Dall'Angelo S, Mingarelli M, Augello A, Schweiger L, Welch A, Elmore CS, Sharma P, Zanda M. Design, synthesis, in vitro characterization and preliminary imaging studies on fluorinated bile acid derivatives as PET tracers to study hepatic transporters. Bioorganic & Medicinal Chemistry. PMID 28011201 DOI: 10.1016/j.bmc.2016.12.008 |
0.319 |
|
2016 |
Allen P, Bragg RA, Caffrey M, Ericsson C, Hickey MJ, Kingston LP, Elmore CS. The synthesis of a tritium, carbon-14 and stable isotope labelled cathepsin C inhibitors. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 27868229 DOI: 10.1002/jlcr.3483 |
0.409 |
|
2016 |
Bragg RA, Bushby N, Ericsson C, Kingston LP, Ji H, Elmore CS. The synthesis of tritium, carbon-14 and stable isotope labelled selective estrogen receptor degraders. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 27558079 DOI: 10.1002/jlcr.3437 |
0.394 |
|
2016 |
Lindelöf Å, Ericsson C, Simonsson R, Nilsson G, Grönberg G, Elmore CS. Synthesis of [(3) H] and [(2) H6 ]AZD6642, an inhibitor of 5-lipoxygenase activating protein (FLAP). Journal of Labelled Compounds & Radiopharmaceuticals. PMID 27298225 DOI: 10.1002/jlcr.3409 |
0.377 |
|
2016 |
Maxwell BD, Elmore CS. Editorial. Journal of Labelled Compounds & Radiopharmaceuticals. 59: 232. PMID 27169759 DOI: 10.1002/jlcr.3401 |
0.15 |
|
2016 |
Aigbirhio FI, Allwein S, Anwar A, Atzrodt J, Audisio D, Badman G, Bakale R, Berthon F, Bragg R, Brindle KM, Bushby N, Campos S, Cant AA, Chan MY, Colbon P, ... ... Elmore CS, et al. Abstracts of the 24th international isotope society (UK group) symposium: synthesis and applications of labelled compounds 2015. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 26991121 DOI: 10.1002/jlcr.3377 |
0.369 |
|
2016 |
Schenk DJ, Lockley WJ, Elmore CS, Hesk D, Roberts D. Determining the isotopic abundance of a labeled compound by mass spectrometry and how correcting for natural abundance distribution using analogous data from the unlabeled compound leads to a systematic error. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 26916110 DOI: 10.1002/Jlcr.3370 |
0.717 |
|
2015 |
Testa A, Zanda M, Elmore CS, Sharma P. PET Tracers To Study Clinically Relevant Hepatic Transporters. Molecular Pharmaceutics. 12: 2203-16. PMID 26034841 DOI: 10.1021/acs.molpharmaceut.5b00059 |
0.255 |
|
2015 |
Anwar A, Archibald S, Audisio D, Badman G, Bergin J, Bew SP, Bloom J, Bushby N, Busigin A, Chan MY, Davies J, Dilworth J, Dunscombe M, Elmore CS, Engstrom P, et al. Abstracts. Journal of Labelled Compounds & Radiopharmaceuticals. 58: 147-55. PMID 25764375 DOI: 10.1002/jlcr.3276 |
0.655 |
|
2015 |
Elmore CS, Bragg RA. Isotope chemistry; a useful tool in the drug discovery arsenal. Bioorganic & Medicinal Chemistry Letters. 25: 167-71. PMID 25499878 DOI: 10.1016/j.bmcl.2014.11.051 |
0.443 |
|
2015 |
Kenna JG, Stahl SH, Eakins JA, Foster AJ, Andersson LC, Bergare J, Billger M, Elebring M, Elmore CS, Thompson RA. Multiple compound-related adverse properties contribute to liver injury caused by endothelin receptor antagonists. The Journal of Pharmacology and Experimental Therapeutics. 352: 281-90. PMID 25467130 DOI: 10.1124/jpet.114.220491 |
0.259 |
|
2015 |
Testa A, Zanda M, Elmore CS, Sharma P. PET Tracers To Study Clinically Relevant Hepatic Transporters Molecular Pharmaceutics. 12: 2203-2216. DOI: 10.1021/acs.molpharmaceut.5b00059 |
0.213 |
|
2015 |
Elmore CS, Bragg RA. Isotope chemistry; A useful tool in the drug discovery arsenal Bioorganic and Medicinal Chemistry Letters. 25: 167-171. DOI: 10.1016/j.bmcl.2014.11.051 |
0.28 |
|
2014 |
Elmore CS, Schenk DJ, Arent R, Kingston L. Evaluation of UV-HPLC and mass spectrometry methods for specific activity determination. Journal of Labelled Compounds & Radiopharmaceuticals. 57: 645-51. PMID 25223538 DOI: 10.1002/Jlcr.3234 |
0.695 |
|
2014 |
Elmore CS, Landvatter S, Dorff PN, Powell ME, Killick D, Blake T, Hall J, Heys JR, Harding J, Urbanek R, Ernst G. Synthesis of three alpha 7 agonists in labeled form. Journal of Labelled Compounds & Radiopharmaceuticals. 57: 342-9. PMID 24700683 DOI: 10.1002/jlcr.3186 |
0.408 |
|
2014 |
Testa A, Piras M, Hickey MJ, Fleming IN, Bushby N, Lenz E, Elmore CS, Zanda M. Multifunctional Deuterated and Tritiated 'Click' Molecular Probes via Palladium-Mediated Reductive Deiodination of 5-Iodo-1,2,3-Triazoles Synlett. 25: 1019-1025. DOI: 10.1055/s-0033-1340940 |
0.237 |
|
2014 |
Aboagye EO, Aigbirhio FI, Allen P, Arent R, Arrowsmith RL, Banci G, Bagley MC, Bailey CD, Blake T, Bunt AJ, Bushby N, Carroll L, Cons BD, Cortezon F, Dilworth JR, ... ... Elmore CS, et al. Abstracts of the 22nd International Isotope Society (UK Group) Symposium: Synthesis and applications of labelled compounds 2013 Journal of Labelled Compounds and Radiopharmaceuticals. DOI: 10.1002/jlcr.3523 |
0.717 |
|
2014 |
Elmore CS, Schenk DJ, Arent R, Kingston L. Evaluation of UV-HPLC and mass spectrometry methods for specific activity determination Journal of Labelled Compounds and Radiopharmaceuticals. 57: 645-651. DOI: 10.1002/jlcr.3234 |
0.675 |
|
2013 |
Brown DG, Bernstein PR, Wu Y, Urbanek RA, Becker CW, Throner SR, Dembofsky BT, Steelman GB, Lazor LA, Scott CW, Wood MW, Wesolowski SS, Nugiel DA, Koch S, Yu J, ... ... Elmore CS, et al. Azepines and piperidines with dual norepinephrine dopamine uptake inhibition and antidepressant activity. Acs Medicinal Chemistry Letters. 4: 46-51. PMID 24900562 DOI: 10.1021/ml300262e |
0.282 |
|
2013 |
Simonsson R, Stenhagen G, Ericsson C, Elmore CS. Synthesis of ximelagatran, melagatran, hydroxymelagatran, and ethylmelagatran in H-3 labeled form Journal of Labelled Compounds and Radiopharmaceuticals. 56: 334-337. PMID 24285415 DOI: 10.1002/jlcr.3028 |
0.352 |
|
2013 |
Guo J, Zhang M, Elmore CS, Vishwanathan K. An integrated strategy for in vivo metabolite profiling using high-resolution mass spectrometry based data processing techniques Analytica Chimica Acta. 780: 55-64. PMID 23680551 DOI: 10.1016/j.aca.2013.04.012 |
0.308 |
|
2013 |
Zhang M, Resuello CM, Guo J, Powell ME, Elmore CS, Hu J, Vishwanathan K. Contribution of artifacts to n-methylated piperazine cyanide adduct formation in vitro from n-alkyl piperazine analogs Drug Metabolism and Disposition. 41: 1023-1034. PMID 23431111 DOI: 10.1124/dmd.112.050450 |
0.278 |
|
2013 |
Zysk JR, Spear N, Fieles W, Stein MM, Sygowski LS, King MM, Hoesch V, Hastings R, Brockel B, Do M, Ström P, Gadient R, Chhajlani V, Elmore CS, Maier DL. In vitro binding of a radio-labeled positive allosteric modulator for metabotropic glutamate receptor subtype 5. Synapse (New York, N.Y.). 67: 135-44. PMID 23150216 DOI: 10.1002/syn.21625 |
0.315 |
|
2012 |
Moran MD, Wilson AA, Elmore CS, Parkes J, Ng A, Sadovski O, Graff A, Daskalakis ZJ, Houle S, Chapdelaine MJ, Vasdev N. Development of new carbon-11 labelled radiotracers for imaging GABA A- and GABA B-benzodiazepine receptors Bioorganic and Medicinal Chemistry. 20: 4482-4488. PMID 22717238 DOI: 10.1016/J.Bmc.2012.05.046 |
0.329 |
|
2012 |
Gu C, Elmore CS, Lin J, Zhou D, Luzietti R, Dorff P, Grimm SW. Metabolism of a G protein-coupled receptor modulator, including two major 1,2,4-oxadiazole ring-opened metabolites and a rearranged cysteine-piperazine adduct Drug Metabolism and Disposition. 40: 1151-1163. PMID 22397852 DOI: 10.1124/dmd.112.044636 |
0.312 |
|
2012 |
Isin EM, Elmore CS, Nilsson GN, Thompson RA, Weidolf L. Use of radiolabeled compounds in drug metabolism and pharmacokinetic studies Chemical Research in Toxicology. 25: 532-542. PMID 22372867 DOI: 10.1021/tx2005212 |
0.311 |
|
2012 |
Ding M, Ghanekar S, Elmore CS, Zysk JR, Werkheiser JL, Lee CM, Liu J, Chhajlani V, Maier DL. [ 3H]Chiba-1001(methyl-SSR180711) has low in vitro binding affinity and poor in vivo selectivity to nicotinic alpha-7 receptor in rodent brain Synapse. 66: 315-322. PMID 22108786 DOI: 10.1002/syn.21513 |
0.262 |
|
2012 |
Lindhardt AT, Simonssen R, Taaning RH, Gøgsig TM, Nilsson GN, Stenhagen G, Elmore CS, Skrydstrup T. 14Carbon monoxide made simple - Novel approach to the generation, utilization, and scrubbing of 14carbon monoxide Journal of Labelled Compounds and Radiopharmaceuticals. 55: 411-418. DOI: 10.1002/Jlcr.2962 |
0.329 |
|
2012 |
Elmore CS, Powell ME, Xiong H, Wu Y, Wang L, Saunders D, Urbanek RA. Preparation of two D2 partial agonists in C-14 and stable isotope labeled forms Journal of Labelled Compounds and Radiopharmaceuticals. 55: 359-365. DOI: 10.1002/jlcr.2951 |
0.359 |
|
2012 |
Aigbirhio F, Appleyard MVCL, Arrowsmith RL, Baldwin SA, Bayrakdarian M, Botting NP, Cantin LD, Carbery DR, Carroll MA, Dixon LI, Dorff PN, Ellames G, Elmore CS, Fishwick CWG, Foot O, et al. Abstracts of the 20th International Isotope Society (UK group) Symposium: Synthesis & Applications of Labelled Compounds 2011 Journal of Labelled Compounds and Radiopharmaceuticals. 55: 125-134. DOI: 10.1002/Jlcr.2907 |
0.622 |
|
2012 |
Maxwell BD, Elmore CS. Radiosynthesis for ADME Studies Adme-Enabling Technologies in Drug Design and Development. 461-472. DOI: 10.1002/9781118180778.ch30 |
0.205 |
|
2011 |
Guo J, Gu C, Zhou D, Elmore CS, Bui KH, Grimm SW. In vitro and in vivo metabolism of a selective δ-opioid receptor Drug Metabolism and Disposition. 39: 1883-1894. PMID 21752944 DOI: 10.1124/Dmd.111.040980 |
0.324 |
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2011 |
Brown DG, Maier DL, Sylvester MA, Hoerter TN, Menhaji-Klotz E, Lasota CC, Hirata LT, Wilkins DE, Scott CW, Trivedi S, Chen T, McCarthy DJ, MacIag CM, Sutton EJ, Cumberledge J, ... ... Elmore CS, et al. 2,6-Disubstituted pyrazines and related analogs as NR2B site antagonists of the NMDA receptor with anti-depressant activity Bioorganic and Medicinal Chemistry Letters. 21: 3399-3403. PMID 21524576 DOI: 10.1016/j.bmcl.2011.03.117 |
0.454 |
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2011 |
Maier DL, Hill G, Ding M, Tuke D, Einstein E, Gurley D, Gordon JC, Bock MJ, Smith JS, Bialecki R, Eisman M, Elmore CS, Werkheiser JL. Pre-clinical validation of a novel alpha-7 nicotinic receptor radiotracer, [(3)H]AZ11637326: target localization, biodistribution and ligand occupancy in the rat brain. Neuropharmacology. 61: 161-71. PMID 21497612 DOI: 10.1016/j.neuropharm.2011.03.024 |
0.273 |
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2011 |
Andersson JD, Pierson ME, Finnema SJ, Gulyás B, Heys R, Elmore CS, Farde L, Halldin C. Development of a PET radioligand for the central 5-HT1B receptor: radiosynthesis and characterization in cynomolgus monkeys of eight radiolabeled compounds. Nuclear Medicine and Biology. 38: 261-72. PMID 21315282 DOI: 10.1016/J.Nucmedbio.2010.08.006 |
0.332 |
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2011 |
Zysk JR, Widzowski D, Sygowski LA, Knappenberger KS, Spear N, Elmore CS, Dorff P, Liu H, Doherty J, Chhajlani V. Absence of direct effects on the dopamine D2 receptor by mGluR2/3-selective receptor agonists LY 354,740 and LY 379,268. Synapse (New York, N.Y.). 65: 64-8. PMID 20506301 DOI: 10.1002/Syn.20817 |
0.323 |
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2011 |
Elmore CS, Brush K, Schou M, Palmer W, Dorff PN, Powell ME, Hoesch V, Hall JE, Hudzik T, Halldin C, Dantzman CL. Synthesis of a delta opioid agonist in [ 2H 6], [ 2H 4], [ 11C], and [ 14C] labeled forms Journal of Labelled Compounds and Radiopharmaceuticals. 54: 847-854. DOI: 10.1002/Jlcr.1939 |
0.364 |
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2011 |
Elmore CS, Dorff PN, Powell ME, Hall JE, Simpson TR. Synthesis of the NK3 receptor antagonist AZD2624 in C-14-, H-3- and C-13-labeled forms Journal of Labelled Compounds and Radiopharmaceuticals. 54: 239-246. DOI: 10.1002/jlcr.1858 |
0.354 |
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2011 |
Dorff PN, Powell ME, Elmore CS. Synthesis of [13C5] and [carbonyl- 14C]-5-chlorofuran-2-carboxylic acid Journal of Labelled Compounds and Radiopharmaceuticals. 54: 123-125. DOI: 10.1002/jlcr.1829 |
0.3 |
|
2011 |
Elmore CS. The synthesis and use of [14C]carbon monoxide in Pd-catalyzed carbonylation reactions Journal of Labelled Compounds and Radiopharmaceuticals. 54: 59-64. DOI: 10.1002/jlcr.1809 |
0.279 |
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2011 |
Elmore CS, Dorff PN. Synthesis of triphenylsilyl[14C2]acetylene for use in a Sonogashira reaction Journal of Labelled Compounds and Radiopharmaceuticals. 54: 51-53. DOI: 10.1002/jlcr.1808 |
0.29 |
|
2010 |
Gordon JC, Edwards P, Elmore CS, Lazor LA, Paschetto K, Bostwick R, Sylvester M, Mauger R, Scott C, Aharony D. [125I]YP20: A novel radioligand specific for the extracellular domain of the CRF1 receptor European Journal of Pharmacology. 649: 59-63. PMID 20854803 DOI: 10.1016/j.ejphar.2010.09.008 |
0.246 |
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2010 |
Peng T, Zysk J, Dorff P, Elmore CS, Ström P, Malmquist J, Ding M, Tuke D, Werkheiser J, Widzowski D, Mrzljak L, Maier D. D2 receptor occupancy in conscious rat brain is not significantly distinguished with [3H]-MNPA, [3H]-(+)-PHNO, and [ 3H]-raclopride Synapse. 64: 624-633. PMID 20340171 DOI: 10.1002/syn.20771 |
0.274 |
|
2010 |
Elmore CS, Dorff PN, Richard Heys J. Syntheses of the tricyclic cores of clozapine, dibenzo[b,f][1,4]thiazepin- 11(10H)-one, and dibenzo[b,f][1,4]oxazepin-11(10H)-one in C-14 labeled form by [14C]carbonylation Journal of Labelled Compounds and Radiopharmaceuticals. 53: 787-792. DOI: 10.1002/jlcr.1802 |
0.298 |
|
2010 |
Elmore CS, Frietze WE, Andisik DW, Ernst GE, Heys JR, Dantzman CL. Synthesis of a C-14 labeled delta-opioid receptor agonist by carbonylation Journal of Labelled Compounds and Radiopharmaceuticals. 53: 394-397. DOI: 10.1002/jlcr.1773 |
0.319 |
|
2009 |
Maier DL, Sobotka-Briner C, Ding M, Powell ME, Jiang Q, Hill G, Heys JR, Elmore CS, Pierson ME, Mrzljak L. [N-methyl-3H3]AZ10419369 binding to the 5-HT 1B receptor: In vitro characterization and in vivo receptor occupancy Journal of Pharmacology and Experimental Therapeutics. 330: 342-351. PMID 19401496 DOI: 10.1124/jpet.109.150722 |
0.291 |
|
2009 |
Elmore CS. The use of isotopically labeled compounds in drug discovery Annual Reports in Medicinal Chemistry. 44: 515-534. DOI: 10.1016/S0065-7743(09)04425-X |
0.382 |
|
2009 |
Heys JR, Elmore CS. Meta-substituent effects on organoiridium-catalyzed ortho-hydrogen isotope exchange Journal of Labelled Compounds and Radiopharmaceuticals. 52: 189-200. DOI: 10.1002/jlcr.1588 |
0.271 |
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2008 |
Ho JZ, Elmore CS, Braun MP. Synthesis of a14C-labeled FPTase inhibitor via a Pd-catalyzed cyanation with Zn(14CN)2 and via bromo[ 14C]acetic acid Journal of Labelled Compounds and Radiopharmaceuticals. 51: 399-403. DOI: 10.1002/jlcr.1545 |
0.299 |
|
2008 |
Elmore CS, Powell ME, Heys JR. Syntheses of AZ12320927 labeled with H-3, C-14, and H-2 Journal of Labelled Compounds and Radiopharmaceuticals. 51: 343-346. DOI: 10.1002/jlcr.1534 |
0.318 |
|
2007 |
Beconi MG, Reed JR, Teffera Y, Xia YQ, Kochansky CJ, Liu DQ, Xu S, Elmore CS, Ciccotto S, Hora DF, Stearns RA, Vincent SH. Disposition of the dipeptidyl peptidase 4 inhibitor sitagliptin in rats and dogs. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 525-32. PMID 17220241 DOI: 10.1124/dmd.106.013110 |
0.271 |
|
2007 |
Vincent SH, Reed JR, Bergman AJ, Elmore CS, Zhu B, Xu S, Ebel D, Larson P, Zeng W, Chen L, Dilzer S, Lasseter K, Gottesdiener K, Wagner JA, Herman GA. Metabolism and excretion of the dipeptidyl peptidase 4 inhibitor [14C]sitagliptin in humans. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 533-8. PMID 17220239 DOI: 10.1124/dmd.106.013136 |
0.284 |
|
2007 |
Powell ME, Elmore CS, Dorff PN, Heys JR. Investigation of isotopic exchange reactions using N-heterocyclic iridium (I) complexes Journal of Labelled Compounds and Radiopharmaceuticals. 50: 523-525. DOI: 10.1002/jlcr.1239 |
0.243 |
|
2007 |
Elmore CS, Hall JE, Ye X, Heys JR. Synthesis of two isotopically labeled 5-HT1B antagonists Journal of Labelled Compounds and Radiopharmaceuticals. 50: 412-413. DOI: 10.1002/jlcr.1164 |
0.39 |
|
2005 |
Zhang AS, Elmore CS, Egan MA, Melillo DG, Dean DC. Use of fluorous and solid-phase electrophiles as scavengers for excess amine in the preparation of sulfur-35 labelled radioligands Journal of Labelled Compounds and Radiopharmaceuticals. 48: 203-208. DOI: 10.1002/jlcr.915 |
0.306 |
|
2005 |
Ho JZ, Elmore CS, Wallace MA, Yao D, Braun MP, Dean DC, Melillo DG, Chen CY. Use of dibutyl[14C]formamide as a formylating reagent in the Vilsmeier-Haack reaction and synthesis of a 14C-labeled novel phosphodiesterase-4 (PDE-4) inhibitor Helvetica Chimica Acta. 88: 1040-1047. DOI: 10.1002/hlca.200590075 |
0.348 |
|
2004 |
Elmore CS, Dean DC, Zhang Y, Mellilo DG. The syntheses of [14C] and [13C2, 15N3]aprepitant Journal of Labelled Compounds and Radiopharmaceuticals. 47: 837-846. DOI: 10.1002/jlcr.872 |
0.282 |
|
2003 |
Elmore CS, Dean DC, DeVita RJ, Melillo DG. Synthesis of two non-peptidyl GnRH receptor antagonists via [ 14C]carbonylation Journal of Labelled Compounds and Radiopharmaceuticals. 46: 993-1000. DOI: 10.1002/jlcr.733 |
0.308 |
|
2002 |
Elmore CS, Dean DC, Zhang Y, Gibson C, Jenkins H, Jones AN, Melillo DG. Synthesis of [C2H3]methotrexate and [C2H3]7-hydroxymethotrexate Journal of Labelled Compounds and Radiopharmaceuticals. 45: 29-36. DOI: 10.1002/jlcr.537 |
0.204 |
|
2000 |
Elmore CS, Dean DC, Melillo DG. A convenient method for [14C]Carbonylation reactions Journal of Labelled Compounds and Radiopharmaceuticals. 43: 1135-1144. DOI: 10.1002/1099-1344(20001015)43:11<1135::AID-JLCR404>3.0.CO;2-T |
0.279 |
|
1997 |
Coates RM, Elmore CS, Croteau RB, Williams DC, Morimoto H, Williams PG. Stereochemistry of the methyl→methylene elimination in the enzyme-catalysed cyclization of geranyl diphosphate to (4S)-limonene Chemical Communications. 2079-2080. DOI: 10.1039/A704370H |
0.49 |
|
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