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Gopal Sapparapu - Publications

Affiliations: 
2007-2012 Pediatrics Vanderbilt University School of Medicine, Nashville, TN, United States 
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32 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Kose N, Fox JM, Sapparapu G, Bombardi R, Tennekoon RN, de Silva AD, Elbashir SM, Theisen MA, Humphris-Narayanan E, Ciaramella G, Himansu S, Diamond MS, Crowe JE. A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection. Science Immunology. 4. PMID 31101672 DOI: 10.1126/Sciimmunol.Aaw6647  0.443
2018 Chukwuma VU, Kose N, Sather DN, Sapparapu G, Falk R, King H, Singh V, Lampley R, Malherbe DC, Ditto NT, Sullivan JT, Barnes T, Doranz BJ, Labranche CC, Montefiori DC, et al. Increased breadth of HIV-1 neutralization achieved by diverse antibody clones each with limited neutralization breadth. Plos One. 13: e0209437. PMID 30566528 DOI: 10.1371/Journal.Pone.0209437  0.837
2018 Goo L, Debbink K, Kose N, Sapparapu G, Doyle MP, Wessel AW, Richner JM, Burgomaster KE, Larman BC, Dowd KA, Diamond MS, Crowe JE, Pierson TC. A protective human monoclonal antibody targeting the West Nile virus E protein preferentially recognizes mature virions. Nature Microbiology. PMID 30455471 DOI: 10.1038/S41564-018-0283-7  0.709
2018 Flyak AI, Kuzmina N, Murin CD, Bryan C, Davidson E, Gilchuk P, Gulka CP, Ilinykh PA, Shen X, Huang K, Ramanathan P, Turner H, Fusco ML, Lampley R, Kose N, ... ... Sapparapu G, et al. Broadly neutralizing antibodies from human survivors target a conserved site in the Ebola virus glycoprotein HR2-MPER region. Nature Microbiology. PMID 29736037 DOI: 10.1038/S41564-018-0157-Z  0.826
2018 Fernandez E, Kose N, Edeling MA, Adhikari J, Sapparapu G, Lazarte SM, Nelson CA, Govero J, Gross ML, Fremont DH, Crowe JE, Diamond MS. Mouse and Human Monoclonal Antibodies Protect against Infection by Multiple Genotypes of Japanese Encephalitis Virus. Mbio. 9. PMID 29487230 DOI: 10.1128/Mbio.00008-18  0.638
2017 Hasan SS, Miller A, Sapparapu G, Fernandez E, Klose T, Long F, Fokine A, Porta JC, Jiang W, Diamond MS, Crowe JE, Kuhn RJ, Rossmann MG. A human antibody against Zika virus crosslinks the E protein to prevent infection. Nature Communications. 8: 14722. PMID 28300075 DOI: 10.1038/Ncomms14722  0.579
2017 Thomsen IP, Sapparapu G, James DB, Cassat JE, Nagarsheth M, Kose N, Putnam N, Boguslawski KM, Jones LS, Wood JB, Creech CB, Torres VJ, Crowe JE. Monoclonal antibodies against the Staphylococcus aureus bicomponent leukotoxin AB (LukAB) isolated following invasive human infection reveal diverse binding and modes of action. The Journal of Infectious Diseases. PMID 28186295 DOI: 10.1093/Infdis/Jix071  0.543
2017 Sirohi D, Chen Z, Sun L, Klose T, Pierson TC, Rossmann MG, Kuhn RJ, Prasad VM, Miller A, Buda G, Hasan SS, Sapparapu G, Fernandez E, Long F, Fokine A, et al. The cryoEM structures of immature and mature Zika virus and of mature Zika virus complexed with a human monoclonal antibody Acta Crystallographica Section a Foundations and Advances. 73: a347-a347. DOI: 10.1107/S0108767317096611  0.61
2016 Nivarthi UK, Kose N, Sapparapu G, Widman D, Gallichotte E, Pfaff JM, Doranz BJ, Weiskopf D, Sette A, Durbin AP, Whitehead SS, Baric R, Crowe JE, de Silva AM. Mapping the Human Memory B Cell and Serum Neutralizing Antibody Responses to DENV4 Infection and Vaccination. Journal of Virology. PMID 28031369 DOI: 10.1128/Jvi.02041-16  0.625
2016 Sapparapu G, Fernandez E, Kose N, Cao B, Fox JM, Bombardi RG, Zhao H, Nelson CA, Bryan AL, Barnes T, Davidson E, Mysorekar IU, Fremont DH, Doranz BJ, Diamond MS, et al. Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice. Nature. PMID 27819683 DOI: 10.1038/Nature20564  0.556
2016 Gilchuk I, Gilchuk P, Sapparapu G, Lampley R, Singh V, Kose N, Blum DL, Hughes LJ, Satheshkumar PS, Townsend MB, Kondas AV, Reed Z, Weiner Z, Olson VA, Hammarlund E, et al. Cross-Neutralizing and Protective Human Antibody Specificities to Poxvirus Infections. Cell. 167: 684-694.e9. PMID 27768891 DOI: 10.1016/J.Cell.2016.09.049  0.835
2016 Shanker S, Czakó R, Sapparapu G, Alvarado G, Viskovska M, Sankaran B, Atmar RL, Crowe JE, Estes MK, Prasad BV. Structural basis for norovirus neutralization by an HBGA blocking human IgA antibody. Proceedings of the National Academy of Sciences of the United States of America. 113: E5830-E5837. PMID 27647885 DOI: 10.1073/Pnas.1609990113  0.798
2016 Bangaru S, Nieusma T, Kose N, Thornburg NJ, Finn JA, Kaplan BS, King HG, Singh V, Lampley RM, Sapparapu G, Cisneros A, Edwards KM, Slaughter JC, Edupuganti S, Lai L, et al. Recognition of influenza H3N2 variant virus by human neutralizing antibodies. Jci Insight. 1. PMID 27482543 DOI: 10.1172/Jci.Insight.86673  0.747
2016 Cho MJ, Ellebrecht CT, Hammers CM, Mukherjee EM, Sapparapu G, Boudreaux CE, McDonald SM, Crowe JE, Payne AS. Determinants of VH1-46 Cross-Reactivity to Pemphigus Vulgaris Autoantigen Desmoglein 3 and Rotavirus Antigen VP6. Journal of Immunology (Baltimore, Md. : 1950). PMID 27402694 DOI: 10.4049/Jimmunol.1600567  0.396
2016 Sapparapu G, Czakó R, Alvarado G, Shanker S, Prasad BV, Atmar RL, Estes MK, Crowe JE. Frequent Use of the IgA Isotype in Human B Cells Encoding Potent Norovirus-Specific Monoclonal Antibodies That Block HBGA Binding. Plos Pathogens. 12: e1005719. PMID 27355511 DOI: 10.1371/Journal.Ppat.1005719  0.816
2016 Willis JR, Finn JA, Briney B, Sapparapu G, Singh V, King H, LaBranche CC, Montefiori DC, Meiler J, Crowe JE. Long antibody HCDR3s from HIV-naïve donors presented on a PG9 neutralizing antibody background mediate HIV neutralization. Proceedings of the National Academy of Sciences of the United States of America. PMID 27044078 DOI: 10.1073/Pnas.1518405113  0.742
2016 Thornburg NJ, Zhang H, Bangaru S, Sapparapu G, Kose N, Lampley RM, Bombardi RG, Yu Y, Graham S, Branchizio A, Yoder SM, Rock MT, Creech CB, Edwards KM, Lee D, et al. H7N9 influenza virus neutralizing antibodies that possess few somatic mutations. The Journal of Clinical Investigation. PMID 26950424 DOI: 10.1172/Jci85317  0.811
2016 Flyak AI, Shen X, Murin CD, Turner HL, David JA, Fusco ML, Lampley R, Kose N, Ilinykh PA, Kuzmina N, Branchizio A, King H, Brown L, Bryan C, Davidson E, ... ... Sapparapu G, et al. Cross-Reactive and Potent Neutralizing Antibody Responses in Human Survivors of Natural Ebolavirus Infection. Cell. PMID 26806128 DOI: 10.1016/J.Cell.2015.12.022  0.838
2016 Thomsen I, James D, Cassat J, Sapparapu G, Creech C, Torres V, Crowe JE. Human Monoclonal Antibodies to the Staphylococcus aureus Toxin LukAB have Distinct Mechanisms of Protection and Are Efficacious In Vivo Open Forum Infectious Diseases. 3. DOI: 10.1093/Ofid/Ofw172.1752  0.528
2015 Smith SA, Nivarthi UK, de Alwis R, Kose N, Sapparapu G, Bombardi R, Kahle KM, Pfaff JM, Lieberman S, Doranz BJ, de Silva AM, Crowe JE. Dengue virus prM-specific human monoclonal antibodies with virus replication enhancing properties recognize a single immunodominant antigenic site. Journal of Virology. PMID 26512092 DOI: 10.1128/Jvi.01805-15  0.749
2015 Long F, Fong RH, Austin SK, Chen Z, Klose T, Fokine A, Liu Y, Porta J, Sapparapu G, Akahata W, Doranz BJ, Crowe JE, Diamond MS, Rossmann MG. Cryo-EM structures elucidate neutralizing mechanisms of anti-chikungunya human monoclonal antibodies with therapeutic activity. Proceedings of the National Academy of Sciences of the United States of America. PMID 26504196 DOI: 10.1073/Pnas.1515558112  0.604
2015 Winarski KL, Thornburg NJ, Yu Y, Sapparapu G, Crowe JE, Spiller BW. Vaccine-elicited antibody that neutralizes H5N1 influenza and variants binds the receptor site and polymorphic sites. Proceedings of the National Academy of Sciences of the United States of America. PMID 26170302 DOI: 10.1073/Pnas.1502762112  0.724
2015 Smith SA, Silva LA, Fox JM, Flyak AI, Kose N, Sapparapu G, Khomadiak S, Ashbrook AW, Kahle KM, Fong RH, Swayne S, Doranz BJ, McGee CE, Heise MT, Pal P, et al. Isolation and Characterization of Broad and Ultrapotent Human Monoclonal Antibodies with Therapeutic Activity against Chikungunya Virus. Cell Host & Microbe. 18: 86-95. PMID 26159721 DOI: 10.1016/J.Chom.2015.06.009  0.819
2015 Willis JR, Sapparapu G, Murrell S, Julien JP, Singh V, King HG, Xia Y, Pickens JA, LaBranche CC, Slaughter JC, Montefiori DC, Wilson IA, Meiler J, Crowe JE. Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth. The Journal of Clinical Investigation. 125: 2523-31. PMID 25985274 DOI: 10.1172/Jci80693  0.775
2015 Flyak AI, Ilinykh PA, Murin CD, Garron T, Shen X, Fusco ML, Hashiguchi T, Bornholdt ZA, Slaughter JC, Sapparapu G, Klages C, Ksiazek TG, Ward AB, Saphire EO, Bukreyev A, et al. Mechanism of human antibody-mediated neutralization of Marburg virus. Cell. 160: 893-903. PMID 25723164 DOI: 10.1016/J.Cell.2015.01.031  0.808
2015 Smith SA, Silva LA, Fox JM, Flyak AI, Kose N, Sapparapu G, Khomandiak S, Ashbrook AW, Kahle KM, Fong RH, Swayne S, Doranz BJ, McGee CE, Heise MT, Pal P, et al. Erratum: Isolation and Characterization of Broad and Ultrapotent Human Monoclonal Antibodies with Therapeutic Activity against Chikungunya Virus (Cell Host and Microbe (2015) 18 (86-95)) Cell Host & Microbe. 18. DOI: 10.1016/J.Chom.2015.08.002  0.804
2014 Planque SA, Mitsuda Y, Chitsazzadeh V, Gorantla S, Poluektova L, Nishiyama Y, Ochsenbauer C, Morris MK, Sapparapu G, Hanson CV, Massey RJ, Paul S. Deficient synthesis of class-switched, HIV-neutralizing antibodies to the CD4 binding site and correction by electrophilic gp120 immunogen. Aids (London, England). 28: 2201-11. PMID 25022597 DOI: 10.1097/Qad.0000000000000392  0.52
2014 Sapparapu G, Sims AL, Aiyegbo MS, Shaikh FY, Harth EM, Crowe JE. Intracellular neutralization of a virus using a cell-penetrating molecular transporter. Nanomedicine (London, England). 9: 1613-24. PMID 24195674 DOI: 10.2217/Nnm.13.139  0.793
2013 Thornburg NJ, Nannemann DP, Blum DL, Belser JA, Tumpey TM, Deshpande S, Fritz GA, Sapparapu G, Krause JC, Lee JH, Ward AB, Lee DE, Li S, Winarski KL, Spiller BW, et al. Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses. The Journal of Clinical Investigation. 123: 4405-9. PMID 23999429 DOI: 10.1172/Jci69377  0.784
2013 Aiyegbo MS, Sapparapu G, Spiller BW, Eli IM, Williams DR, Kim R, Lee DE, Liu T, Li S, Woods VL, Nannemann DP, Meiler J, Stewart PL, Crowe JE. Human rotavirus VP6-specific antibodies mediate intracellular neutralization by binding to a quaternary structure in the transcriptional pore. Plos One. 8: e61101. PMID 23671563 DOI: 10.1371/Journal.Pone.0061101  0.815
2012 Sapparapu G, Planque S, Mitsuda Y, McLean G, Nishiyama Y, Paul S. Constant domain-regulated antibody catalysis. The Journal of Biological Chemistry. 287: 36096-104. PMID 22948159 DOI: 10.1074/Jbc.M112.401075  0.466
2009 Sapparapu G, Planque SA, Nishiyama Y, Foung SK, Paul S. Antigen-specific proteolysis by hybrid antibodies containing promiscuous proteolytic light chains paired with an antigen-binding heavy chain. The Journal of Biological Chemistry. 284: 24622-33. PMID 19542217 DOI: 10.1074/Jbc.M109.011858  0.425
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