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Jane A. Little, M.D. - Publications

Affiliations: 
1990-2000 University of Minnesota, Twin Cities, Minneapolis, MN 
 2001-2006 National Institutes of Health, Bethesda, MD 
 2006-2011 Albert Einstein College of Medicine, New York, New York, United States 
 2011-2018 Case Western Reserve University, Cleveland Heights, OH, United States 
 2018- University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
hematology
Website:
https://www.med.unc.edu/medicine/directory/jane-little/
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33 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Nouraie M, Ashley-Koch AE, Garrett ME, Sritharan N, Zhang Y, Little J, Gordeuk VR, Gladwin MT, Telen MJ, Kato GJ. Serum albumin is independently associated with higher mortality in adult sickle cell patients: Results of three independent cohorts. Plos One. 15: e0237543. PMID 32776978 DOI: 10.1371/journal.pone.0237543  1
2019 Farrell AT, Panepinto J, Desai AA, Kassim AA, Lebensburger J, Walters MC, Bauer DE, Blaylark RM, DiMichele DM, Gladwin MT, Green NS, Hassell K, Kato GJ, Klings ES, Kohn DB, ... ... Little J, et al. End points for sickle cell disease clinical trials: renal and cardiopulmonary, cure, and low-resource settings. Blood Advances. 3: 4002-4020. PMID 31809537 DOI: 10.1182/bloodadvances.2019000883  1
2019 Nouraie M, Little JA, Hildesheim M, Gibbs JSR, Morris CR, Machado RF, Kato GJ, Gordeuk VR, Gladwin MT. Validation of a composite vascular high risk profile for adult patients with sickle cell disease. American Journal of Hematology. PMID 31444803 DOI: 10.1002/ajh.25624  1
2019 Sinha AA, Adusumilli T, Cohen HW, Nouraie M, Little J, Manwani D. Splenectomy is not associated with a higher tricuspid regurgitant jet velocity in people with sickle cell anemia. Pediatric Blood & Cancer. e27928. PMID 31322833 DOI: 10.1002/pbc.27928  1
2019 Advani A, Cooper BW, Visconte V, Elson P, Chan R, Carew JS, Wei W, Mukherjee S, Gerds A, Carraway H, Nazha A, Hamilton B, Sobecks RM, Caimi PF, Tomlinson B, ... ... Little J, et al. A Phase 1/2 Trial of MEC (Mitoxantrone, Etoposide, Cytarabine) in Combination with Ixazomib for Relapsed/ Refractory Acute Myeloid Leukemia. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30992301 DOI: 10.1158/1078-0432.CCR-18-3886  1
2018 Hambley BC, Abdul Rahman R, Reback M, O'Riordan MA, Langer N, Gilkeson RC, Ginwalla M, Little JA, Schilz R. Intracardiac or intrapulmonary shunts were present in at least 35% of adults with homozygous sickle cell disease followed in an outpatient clinic. Haematologica. PMID 30006446 DOI: 10.3324/haematol.2018.196212  1
2016 Rotz SJ, O'Riordan MA, Kim C, Langer N, Cruz C, Schilz R, Lance C, Little JA. Nocturnal hemoglobin desaturation is associated with reticulocytosis in adults with sickle cell disease and is independent of obstructive sleep apnea. American Journal of Hematology. PMID 27220489 DOI: 10.1002/ajh.24432  1
2016 Alapan Y, Kim C, Adhikari A, Gray KE, Gurkan-Cavusoglu E, Little JA, Gurkan UA. Sickle cell disease biochip: a functional red blood cell adhesion assay for monitoring sickle cell disease. Translational Research : the Journal of Laboratory and Clinical Medicine. PMID 27063958 DOI: 10.1016/j.trsl.2016.03.008  1
2016 Drawz P, Ayyappan S, Nouraie M, Saraf S, Gordeuk V, Hostetter T, Gladwin MT, Little J. Kidney Disease among Patients with Sickle Cell Disease, Hemoglobin SS and SC. Clinical Journal of the American Society of Nephrology : Cjasn. 11: 207-15. PMID 26672090 DOI: 10.2215/CJN.03940415  1
2015 Karkashon S, Raghupathy R, Bhatia H, Dutta A, Hess S, Higgs J, Tifft CJ, Little JA. Intermediaries of branched chain amino acid metabolism induce fetal hemoglobin, and repress SOX6 and BCL11A, in definitive erythroid cells. Blood Cells, Molecules & Diseases. 55: 161-7. PMID 26142333 DOI: 10.1016/j.bcmd.2015.05.006  1
2015 Rotz SJ, O'Riordan MA, Kim C, de Lima M, Gladwin MT, Little JA. Traffic Light: prognosis-based eligibility for clinical trials of hematopoietic SCT in adults with sickle cell anemia. Bone Marrow Transplantation. 50: 918-23. PMID 25774596 DOI: 10.1038/bmt.2015.11  1
2014 Alapan Y, Little JA, Gurkan UA. Heterogeneous red blood cell adhesion and deformability in sickle cell disease. Scientific Reports. 4: 7173. PMID 25417696 DOI: 10.1038/srep07173  1
2014 Gladwin MT, Barst RJ, Gibbs JS, Hildesheim M, Sachdev V, Nouraie M, Hassell KL, Little JA, Schraufnagel DE, Krishnamurti L, Novelli E, Girgis RE, Morris CR, Berman Rosenzweig E, Badesch DB, et al. Risk factors for death in 632 patients with sickle cell disease in the United States and United Kingdom. Plos One. 9: e99489. PMID 24988120 DOI: 10.1371/journal.pone.0099489  1
2014 Saraf SL, Zhang X, Kanias T, Lash JP, Molokie RE, Oza B, Lai C, Rowe JH, Gowhari M, Hassan J, Desimone J, Machado RF, Gladwin MT, Little JA, Gordeuk VR. Haemoglobinuria is associated with chronic kidney disease and its progression in patients with sickle cell anaemia. British Journal of Haematology. 164: 729-39. PMID 24329963 DOI: 10.1111/bjh.12690  1
2013 Nouraie M, Lee JS, Zhang Y, Kanias T, Zhao X, Xiong Z, Oriss TB, Zeng Q, Kato GJ, Gibbs JS, Hildesheim ME, Sachdev V, Barst RJ, Machado RF, Hassell KL, ... Little JA, et al. The relationship between the severity of hemolysis, clinical manifestations and risk of death in 415 patients with sickle cell anemia in the US and Europe. Haematologica. 98: 464-72. PMID 22983573 DOI: 10.3324/haematol.2012.068965  1
2012 Breda L, Casu C, Gardenghi S, Bianchi N, Cartegni L, Narla M, Yazdanbakhsh K, Musso M, Manwani D, Little J, Gardner LB, Kleinert DA, Prus E, Fibach E, Grady RW, et al. Therapeutic hemoglobin levels after gene transfer in β-thalassemia mice and in hematopoietic cells of β-thalassemia and sickle cells disease patients. Plos One. 7: e32345. PMID 22479321 DOI: 10.1371/journal.pone.0032345  1
2011 Sachdev V, Kato GJ, Gibbs JS, Barst RJ, Machado RF, Nouraie M, Hassell KL, Little JA, Schraufnagel DE, Krishnamurti L, Novelli EM, Girgis RE, Morris CR, Rosenzweig EB, Badesch DB, et al. Echocardiographic markers of elevated pulmonary pressure and left ventricular diastolic dysfunction are associated with exercise intolerance in adults and adolescents with homozygous sickle cell anemia in the United States and United Kingdom. Circulation. 124: 1452-60. PMID 21900080 DOI: 10.1161/CIRCULATIONAHA.111.032920  1
2011 Machado RF, Barst RJ, Yovetich NA, Hassell KL, Kato GJ, Gordeuk VR, Gibbs JS, Little JA, Schraufnagel DE, Krishnamurti L, Girgis RE, Morris CR, Rosenzweig EB, Badesch DB, Lanzkron S, et al. Hospitalization for pain in patients with sickle cell disease treated with sildenafil for elevated TRV and low exercise capacity. Blood. 118: 855-64. PMID 21527519 DOI: 10.1182/blood-2010-09-306167  1
2011 McGrath KE, Frame JM, Fromm GJ, Koniski AD, Kingsley PD, Little J, Bulger M, Palis J. A transient definitive erythroid lineage with unique regulation of the β-globin locus in the mammalian embryo. Blood. 117: 4600-8. PMID 21378272 DOI: 10.1182/blood-2010-12-325357  1
2011 Dutta A, Karkashon S, Raghupathy R, Bhatia H, Tesfa L, Little JA. Induction of fetal/embryonic globin gene expression depends on intact cell signaling in definitive erythroid cells. Blood Cells, Molecules & Diseases. 46: 125-32. PMID 21094617 DOI: 10.1016/j.bcmd.2010.10.013  1
2010 Raghupathy R, Manwani D, Little JA. Iron overload in sickle cell disease. Advances in Hematology. 2010: 272940. PMID 20490352 DOI: 10.1155/2010/272940  1
2009 Bhatia H, Hallock JL, Dutta A, Karkashon S, Sterner LS, Miyazaki T, Dean A, Little JA. Short-chain fatty acid-mediated effects on erythropoiesis in primary definitive erythroid cells. Blood. 113: 6440-8. PMID 19380871 DOI: 10.1182/blood-2008-09-171728  1
2009 Little JA, Hauser KP, Martyr SE, Harris A, Maric I, Morris CR, Suh JH, Taylor J, Castro O, Machado R, Kato G, Gladwin MT. Hematologic, biochemical, and cardiopulmonary effects of L-arginine supplementation or phosphodiesterase 5 inhibition in patients with sickle cell disease who are on hydroxyurea therapy. European Journal of Haematology. 82: 315-21. PMID 19215288 DOI: 10.1111/j.1600-0609.2009.01210.x  1
2008 Kiefer CM, Hou C, Little JA, Dean A. Epigenetics of beta-globin gene regulation. Mutation Research. 647: 68-76. PMID 18760288 DOI: 10.1016/j.mrfmmm.2008.07.014  1
2006 Little JA, McGowan VR, Kato GJ, Partovi KS, Feld JJ, Maric I, Martyr S, Taylor JG, Machado RF, Heller T, Castro O, Gladwin MT. Combination erythropoietin-hydroxyurea therapy in sickle cell disease: experience from the National Institutes of Health and a literature review. Haematologica. 91: 1076-83. PMID 16885048  1
2006 Kato GJ, Hsieh M, Machado R, Taylor J, Little J, Butman JA, Lehky T, Tisdale J, Gladwin MT. Cerebrovascular disease associated with sickle cell pulmonary hypertension. American Journal of Hematology. 81: 503-10. PMID 16755569 DOI: 10.1002/ajh.20642  1
2006 Kato GJ, McGowan V, Machado RF, Little JA, Taylor J, Morris CR, Nichols JS, Wang X, Poljakovic M, Morris SM, Gladwin MT. Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease. Blood. 107: 2279-85. PMID 16291595 DOI: 10.1182/blood-2005-06-2373  1
2003 Dempsey NJ, Ojalvo LS, Wu DW, Little JA. Induction of an embryonic globin gene promoter by short-chain fatty acids. Blood. 102: 4214-22. PMID 12920040 DOI: 10.1182/blood-2002-12-3766  1
1998 Ginder GD, Singal R, Little JA, Dempsey N, Ferris R, Wang SZ. Silencing and activation of embryonic globin gene expression. Annals of the New York Academy of Sciences. 850: 70-9. PMID 9668529 DOI: 10.1111/j.1749-6632.1998.tb10464.x  1
1997 Singal R, Ferris R, Little JA, Wang SZ, Ginder GD. Methylation of the minimal promoter of an embryonic globin gene silences transcription in primary erythroid cells. Proceedings of the National Academy of Sciences of the United States of America. 94: 13724-9. PMID 9391093 DOI: 10.1073/pnas.94.25.13724  1
1995 Sher GD, Ginder GD, Little J, Yang S, Dover GJ, Olivieri NF. Extended therapy with intravenous arginine butyrate in patients with beta-hemoglobinopathies. The New England Journal of Medicine. 332: 1606-10. PMID 7753139 DOI: 10.1056/NEJM199506153322404  1
1995 Little JA, Dempsey NJ, Tuchman M, Ginder GD. Metabolic persistence of fetal hemoglobin. Blood. 85: 1712-8. PMID 7535584  1
1991 Glauber JG, Wandersee NJ, Little JA, Ginder GD. 5'-flanking sequences mediate butyrate stimulation of embryonic globin gene expression in adult erythroid cells. Molecular and Cellular Biology. 11: 4690-7. PMID 1875947 DOI: 10.1128/mcb.11.9.4690  1
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