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Jane A. Little, M.D. - Publications

Affiliations: 
1990-2000 University of Minnesota, Twin Cities, Minneapolis, MN 
 2001-2006 National Institutes of Health, Bethesda, MD 
 2006-2011 Albert Einstein College of Medicine, New York, New York, United States 
 2011-2018 Case Western Reserve University, Cleveland Heights, OH, United States 
 2018- University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
hematology
Website:
https://www.med.unc.edu/medicine/directory/jane-little/
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54/118 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Johnson S, Gordeuk VR, Machado R, Gibbs JSR, Hildesheim M, Little JA, Kato GJ, Gladwin MT, Nouraie M. Exercise Induced Changes of Vital Signs in Adults with Sickle Cell Disease. American Journal of Hematology. PMID 34626431 DOI: 10.1002/ajh.26369  0.452
2020 Kucukal E, Man Y, Quinn E, Tewari N, An R, Ilich A, Key NS, Little JA, Gurkan UA. Red blood cell adhesion to ICAM-1 is mediated by fibrinogen and is associated with right-to-left shunts in sickle cell disease. Blood Advances. 4: 3688-3698. PMID 32777069 DOI: 10.1182/Bloodadvances.2020001656  0.334
2020 Nouraie M, Ashley-Koch AE, Garrett ME, Sritharan N, Zhang Y, Little J, Gordeuk VR, Gladwin MT, Telen MJ, Kato GJ. Serum albumin is independently associated with higher mortality in adult sickle cell patients: Results of three independent cohorts. Plos One. 15: e0237543. PMID 32776978 DOI: 10.1371/Journal.Pone.0237543  0.485
2020 Kucukal E, Man Y, Hill A, Liu S, Bode A, An R, Kadambi J, Little JA, Gurkan UA. Whole blood viscosity and red blood cell adhesion: Potential biomarkers for targeted and curative therapies in sickle cell disease. American Journal of Hematology. PMID 32656816 DOI: 10.1002/Ajh.25933  0.341
2020 Man Y, Kucukal E, An R, Watson QD, Bosch J, Zimmerman PA, Little JA, Gurkan UA. Microfluidic assessment of red blood cell mediated microvascular occlusion. Lab On a Chip. PMID 32427268 DOI: 10.1039/D0Lc00112K  0.351
2020 Man Y, Goreke U, Kucukal E, Hill A, An R, Liu S, Bode A, Solis-Fuentes A, Nayak LV, Little JA, Gurkan UA. Leukocyte adhesion to P-selectin and the inhibitory role of Crizanlizumab in sickle cell disease: A standardized microfluidic assessment. Blood Cells, Molecules & Diseases. 83: 102424. PMID 32208292 DOI: 10.1016/J.Bcmd.2020.102424  0.333
2019 Farrell AT, Panepinto J, Desai AA, Kassim AA, Lebensburger J, Walters MC, Bauer DE, Blaylark RM, DiMichele DM, Gladwin MT, Green NS, Hassell K, Kato GJ, Klings ES, Kohn DB, ... ... Little J, et al. End points for sickle cell disease clinical trials: renal and cardiopulmonary, cure, and low-resource settings. Blood Advances. 3: 4002-4020. PMID 31809537 DOI: 10.1182/Bloodadvances.2019000883  0.462
2019 Nouraie M, Little JA, Hildesheim M, Gibbs JSR, Morris CR, Machado RF, Kato GJ, Gordeuk VR, Gladwin MT. Validation of a composite vascular high risk profile for adult patients with sickle cell disease. American Journal of Hematology. PMID 31444803 DOI: 10.1002/Ajh.25624  0.484
2019 Carden MA, Little J. Emerging non-genetic therapies for sickle cell disease. Haematologica. PMID 31413089 DOI: 10.3324/Haematol.2018.207357  0.407
2019 Sinha AA, Adusumilli T, Cohen HW, Nouraie M, Little J, Manwani D. Splenectomy is not associated with a higher tricuspid regurgitant jet velocity in people with sickle cell anemia. Pediatric Blood & Cancer. e27928. PMID 31322833 DOI: 10.1002/Pbc.27928  0.358
2019 Gollamudi J, Sarvepalli S, Alin T, Vadaparti A, Little JA, Nayak LV. Venous Thromboembolism (VTE) in Sickle Cell Disease (SCD) Is Associated with Neutrophilia Blood. 134: 791-791. DOI: 10.1182/Blood-2019-128855  0.355
2019 McLean A, Young L, Boynton MH, Wilson S, Little JA, Carden MA. Prevalence and Monitoring of Diabetes Among Adults with Sickle Cell Disease: A Single Institution Experience Blood. 134: 4832-4832. DOI: 10.1182/Blood-2019-128843  0.363
2019 Saraf SL, Derebail VK, Zhang X, Gladwin MT, Gordeuk VR, Little JA. Manifestations of Reduced Kidney Function Occur at a Higher Estimated Glomerular Filtration Rate in Sickle Cell Anemia Blood. 134: 2268-2268. DOI: 10.1182/Blood-2019-124737  0.438
2016 Drawz P, Ayyappan S, Nouraie M, Saraf S, Gordeuk V, Hostetter T, Gladwin MT, Little J. Kidney Disease among Patients with Sickle Cell Disease, Hemoglobin SS and SC. Clinical Journal of the American Society of Nephrology : Cjasn. 11: 207-15. PMID 26672090 DOI: 10.2215/Cjn.03940415  0.408
2015 Karkashon S, Raghupathy R, Bhatia H, Dutta A, Hess S, Higgs J, Tifft CJ, Little JA. Intermediaries of branched chain amino acid metabolism induce fetal hemoglobin, and repress SOX6 and BCL11A, in definitive erythroid cells. Blood Cells, Molecules & Diseases. 55: 161-7. PMID 26142333 DOI: 10.1016/J.Bcmd.2015.05.006  0.344
2015 Rotz SJ, O'Riordan MA, Kim C, de Lima M, Gladwin MT, Little JA. Traffic Light: prognosis-based eligibility for clinical trials of hematopoietic SCT in adults with sickle cell anemia. Bone Marrow Transplantation. 50: 918-23. PMID 25774596 DOI: 10.1038/Bmt.2015.11  0.441
2014 Gladwin MT, Barst RJ, Gibbs JS, Hildesheim M, Sachdev V, Nouraie M, Hassell KL, Little JA, Schraufnagel DE, Krishnamurti L, Novelli E, Girgis RE, Morris CR, Berman Rosenzweig E, Badesch DB, et al. Risk factors for death in 632 patients with sickle cell disease in the United States and United Kingdom. Plos One. 9: e99489. PMID 24988120 DOI: 10.1371/Journal.Pone.0099489  0.422
2014 Saraf SL, Zhang X, Kanias T, Lash JP, Molokie RE, Oza B, Lai C, Rowe JH, Gowhari M, Hassan J, Desimone J, Machado RF, Gladwin MT, Little JA, Gordeuk VR. Haemoglobinuria is associated with chronic kidney disease and its progression in patients with sickle cell anaemia. British Journal of Haematology. 164: 729-39. PMID 24329963 DOI: 10.1111/Bjh.12690  0.441
2013 Nouraie M, Lee JS, Zhang Y, Kanias T, Zhao X, Xiong Z, Oriss TB, Zeng Q, Kato GJ, Gibbs JS, Hildesheim ME, Sachdev V, Barst RJ, Machado RF, Hassell KL, ... Little JA, et al. The relationship between the severity of hemolysis, clinical manifestations and risk of death in 415 patients with sickle cell anemia in the US and Europe. Haematologica. 98: 464-72. PMID 22983573 DOI: 10.3324/Haematol.2012.068965  0.44
2012 Ayyappan S, Drawz P, Nouraie M, Hildesheim ME, Zhang Y, Gordeuk VR, Hostetter TH, Gladwin MT, Little JA. Renal Disease in Sickle Cell: Clinically Varied and Associated with Increased Mortality Blood. 120: 90-90. DOI: 10.1182/Blood.V120.21.90.90  0.451
2011 Sachdev V, Kato GJ, Gibbs JS, Barst RJ, Machado RF, Nouraie M, Hassell KL, Little JA, Schraufnagel DE, Krishnamurti L, Novelli EM, Girgis RE, Morris CR, Rosenzweig EB, Badesch DB, et al. Echocardiographic markers of elevated pulmonary pressure and left ventricular diastolic dysfunction are associated with exercise intolerance in adults and adolescents with homozygous sickle cell anemia in the United States and United Kingdom. Circulation. 124: 1452-60. PMID 21900080 DOI: 10.1161/Circulationaha.111.032920  0.461
2011 Machado RF, Barst RJ, Yovetich NA, Hassell KL, Kato GJ, Gordeuk VR, Gibbs JS, Little JA, Schraufnagel DE, Krishnamurti L, Girgis RE, Morris CR, Rosenzweig EB, Badesch DB, Lanzkron S, et al. Hospitalization for pain in patients with sickle cell disease treated with sildenafil for elevated TRV and low exercise capacity. Blood. 118: 855-64. PMID 21527519 DOI: 10.1182/Blood-2010-09-306167  0.493
2011 McGrath KE, Frame JM, Fromm GJ, Koniski AD, Kingsley PD, Little J, Bulger M, Palis J. A transient definitive erythroid lineage with unique regulation of the β-globin locus in the mammalian embryo. Blood. 117: 4600-8. PMID 21378272 DOI: 10.1182/Blood-2010-12-325357  0.363
2011 Lorch D, Spevack D, Little J. An elevated estimated pulmonary arterial systolic pressure, whenever measured, is associated with excess mortality in adults with sickle cell disease. Acta Haematologica. 125: 225-9. PMID 21282944 DOI: 10.1159/000323464  0.327
2011 Dutta A, Karkashon S, Raghupathy R, Bhatia H, Tesfa L, Little JA. Induction of fetal/embryonic globin gene expression depends on intact cell signaling in definitive erythroid cells. Blood Cells, Molecules & Diseases. 46: 125-32. PMID 21094617 DOI: 10.1016/J.Bcmd.2010.10.013  0.425
2011 Goel R, Hassell KL, Machado RF, Barst RJ, Yovetich N, Kato GJ, Gordeuk VR, Little JA, Gibbs JSR, Schraufnagel DE, Girgis RE, Rosenzweig EB, Morris CR, Badesch DB, Lanzkron S, et al. Non-Cardiopulmonary Factors Affecting the Six-Minute Walk Distance in Patients with Sickle Cell Disease: Results From the Walk-PHaSST Study Blood. 118: 1074-1074. DOI: 10.1182/Blood.V118.21.1074.1074  0.494
2010 Raghupathy R, Manwani D, Little JA. Iron overload in sickle cell disease. Advances in Hematology. 2010: 272940. PMID 20490352 DOI: 10.1155/2010/272940  0.348
2010 Barst RJ, Kato GJ, Sachdev V, Nouraie M, Machado RF, Hassell K, Gibbs S, Little J, Schraufnagel DE, Krishnamurti L, Girgis RE, Morris CR, Badesch DB, Lanzkron S, Castro O, et al. Predictors of Six-Minute Walk Distance In Adults with Sickle Cell Anemia In the Walk-PHaSST Study Blood. 116: 947-947. DOI: 10.1182/Blood.V116.21.947.947  0.527
2010 Goel R, Hassell K, Castro O, Barst RJ, Rosenzweig EB, Sachdev V, Machado RF, Gibbs S, Little JA, Schraufnagel DE, Girgis RE, Morris CR, Badesch DB, Lanzkron S, Goldsmith JC, et al. Cigarette Smoking Is An Independent Predictor of Chronic Pain In Sickle Cell Patients: Results From the Walk-PHaSST Study Blood. 116: 4804-4804. DOI: 10.1182/Blood.V116.21.4804.4804  0.435
2010 Krishnamurti L, Goel R, Castro O, Barst RJ, Rosenzweig EB, Sachdev V, Machado RF, Gibbs S, Little JA, Schraufnagel DE, Girgis RE, Morris CR, Badesch DB, Lanzkron S, Goldsmith JC, et al. Chronic Pain Is An Independent Predictor of Lower 6 Minute Walk Distance In Patients with Sickle Cell Disease: Results From Walk-PHaSST Study Blood. 116: 2658-2658. DOI: 10.1182/Blood.V116.21.2658.2658  0.442
2010 Raghupathy R, Karkashon S, Fazzari MJ, Little JA. Butyrate Downregulates the Expression of a Number of Repressors of Fetal Hemoglobin In Definitive Erythroid Cells Blood. 116: 2080-2080. DOI: 10.1182/Blood.V116.21.2080.2080  0.445
2010 Nouraie M, Barst RJ, Rosenzweig EB, Sachdev V, Machado RF, Hassell K, Gibbs JSR, Little JA, Schraufnagel DE, Krishnamurti L, Novelli EM, Girgis RE, Morris CR, Badesch DB, Lanzkron S, et al. NT-Probnp as a Marker of Cardiopulmonary Compromise and Exercise Limitation In Adults with Sickle Cell Anemia In the Walk-PHaSST Study Blood. 116: 1639-1639. DOI: 10.1182/Blood.V116.21.1639.1639  0.52
2009 Bhatia H, Hallock JL, Dutta A, Karkashon S, Sterner LS, Miyazaki T, Dean A, Little JA. Short-chain fatty acid-mediated effects on erythropoiesis in primary definitive erythroid cells. Blood. 113: 6440-8. PMID 19380871 DOI: 10.1182/Blood-2008-09-171728  0.666
2009 Little JA, Hauser KP, Martyr SE, Harris A, Maric I, Morris CR, Suh JH, Taylor J, Castro O, Machado R, Kato G, Gladwin MT. Hematologic, biochemical, and cardiopulmonary effects of L-arginine supplementation or phosphodiesterase 5 inhibition in patients with sickle cell disease who are on hydroxyurea therapy. European Journal of Haematology. 82: 315-21. PMID 19215288 DOI: 10.1111/J.1600-0609.2009.01210.X  0.491
2009 Machado RF, Barst RJ, Yovetich NA, Hassell KL, Goldsmith JC, Woolson R, Gordeuk VR, Gibbs S, Little JA, Kato GJ, Schraufnagel DE, Krishnamurti L, Girgis RE, Morris CR, Berman-Rosenzweig E, et al. Safety and Efficacy of Sildenafil Therapy for Doppler-Defined Pulmonary Hypertension in Patients with Sickle Cell Disease: Preliminary Results of the Walk-PHaSST Clinical Trial. Blood. 114: 571-571. DOI: 10.1182/Blood.V114.22.571.571  0.49
2009 Dutta A, Bhatia H, Karkashon S, Tesfa L, Little J. Short Chain Fatty Acids and p38 in the Induction of Embryonic/Fetal Globin Genes During Definitive Erythropoiesis. Blood. 114: 460-460. DOI: 10.1182/Blood.V114.22.460.460  0.409
2009 McGrath KE, Frame JM, Fromm G, Koniski AD, Kingsley PD, Little J, Bulger M, Palis J. “Definitive” Erythropoiesis Has Distinct Developmental Origins and Globin Expression Patterns in the Mammalian Embryo. Blood. 114: 2539-2539. DOI: 10.1182/Blood.V114.22.2539.2539  0.385
2009 Lorch D, Spevack D, Little J. Chronic Kidney Disease and Mild Elevations in Pulmonary Arterial Systolic Pressure Are Associated with Increased Mortality in Adult Patients with Sickle Cell Disease. Blood. 114: 1539-1539. DOI: 10.1182/Blood.V114.22.1539.1539  0.38
2008 Kiefer CM, Hou C, Little JA, Dean A. Epigenetics of beta-globin gene regulation. Mutation Research. 647: 68-76. PMID 18760288 DOI: 10.1016/J.Mrfmmm.2008.07.014  0.641
2008 Bhatia H, Hallock JL, Sterner LE, Karkashon S, Dutta A, Miyazaki T, Dean A, Little J. A Novel Model of Short Chain Fatty Acid (SCFA)- Mediated up-Regulation of Embryonic/Fetal Globin Genes during Definitive Erythropoiesis. Blood. 112: 1878-1878. DOI: 10.1182/Blood.V112.11.1878.1878  0.655
2007 Bhatia H, Higgs J, Hess S, Tifft C, Little J. Intermediaries of Branched-Chain Amino Acid Metabolism Can Increase Fetal Hemoglobin In Vitro and In Vivo. Blood. 110: 3834-3834. DOI: 10.1182/Blood.V110.11.3834.3834  0.398
2007 Little JA, Hauser KP, Martyr SE, Kato GJ, Machado R, Castro O, Taylor J, Gladwin MT. Phosphodiesterase Inhibition Increases Fetal Hemoglobin in Sickle Cell Disease; L-Arginine Supplementation Does Not. Blood. 110: 3396-3396. DOI: 10.1182/Blood.V110.11.3396.3396  0.496
2007 Bhatia H, Hallock J, Sterner L, Miyazaki T, Dean A, Little J. Endogenous Elevations of Short Chain Fatty Acids (SCFAs) Can Up-Regulate Embryonic Globin Gene Expression. Blood. 110: 1770-1770. DOI: 10.1182/Blood.V110.11.1770.1770  0.639
2006 Little JA, McGowan VR, Kato GJ, Partovi KS, Feld JJ, Maric I, Martyr S, Taylor JG, Machado RF, Heller T, Castro O, Gladwin MT. Combination erythropoietin-hydroxyurea therapy in sickle cell disease: experience from the National Institutes of Health and a literature review. Haematologica. 91: 1076-83. PMID 16885048 DOI: 10.3324/%%X  0.517
2006 Kato GJ, Hsieh M, Machado R, Taylor J, Little J, Butman JA, Lehky T, Tisdale J, Gladwin MT. Cerebrovascular disease associated with sickle cell pulmonary hypertension. American Journal of Hematology. 81: 503-10. PMID 16755569 DOI: 10.1002/Ajh.20642  0.494
2006 Kato GJ, McGowan V, Machado RF, Little JA, Taylor J, Morris CR, Nichols JS, Wang X, Poljakovic M, Morris SM, Gladwin MT. Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease. Blood. 107: 2279-85. PMID 16291595 DOI: 10.1182/Blood-2005-06-2373  0.444
2005 Hallock JL, Sterner LJ, Little JA. Enhanced Erythroid Differentiation of Murine Embryoid Bodies That Are Exposed to Short-Chain Fatty Acids during Development. Blood. 106: 3646-3646. DOI: 10.1182/Blood.V106.11.3646.3646  0.427
2005 Partovi K, Martyr S, McGowan V, Machado R, Taylor J, Kato G, Gladwin M, Little J. Early Predictors of Fetal Hemoglobin Response to Hydroxyurea in Sickle Cell Disease. Blood. 106: 2344-2344. DOI: 10.1182/Blood.V106.11.2344.2344  0.501
2004 Sterner L, Miyazaki T, Swift L, Dean A, Little J. Endogenous Elevations of Short Chain Fatty Acids Up-Regulate Embryonic Globin Gene Expression during Primitive Erythropoiesis. Blood. 104: 1210-1210. DOI: 10.1182/Blood.V104.11.1210.1210  0.636
1998 Ginder GD, Singal R, Little JA, Dempsey N, Ferris R, Wang SZ. Silencing and activation of embryonic globin gene expression. Annals of the New York Academy of Sciences. 850: 70-9. PMID 9668529 DOI: 10.1111/J.1749-6632.1998.Tb10464.X  0.646
1997 Singal R, Ferris R, Little JA, Wang SZ, Ginder GD. Methylation of the minimal promoter of an embryonic globin gene silences transcription in primary erythroid cells. Proceedings of the National Academy of Sciences of the United States of America. 94: 13724-9. PMID 9391093 DOI: 10.1073/Pnas.94.25.13724  0.612
1995 Sher GD, Ginder GD, Little J, Yang S, Dover GJ, Olivieri NF. Extended therapy with intravenous arginine butyrate in patients with beta-hemoglobinopathies. The New England Journal of Medicine. 332: 1606-10. PMID 7753139 DOI: 10.1056/Nejm199506153322404  0.615
1995 Little JA, Dempsey NJ, Tuchman M, Ginder GD. Metabolic persistence of fetal hemoglobin. Blood. 85: 1712-8. PMID 7535584 DOI: 10.1182/Blood.V85.7.1712.Bloodjournal8571712  0.625
1991 Glauber JG, Wandersee NJ, Little JA, Ginder GD. 5'-flanking sequences mediate butyrate stimulation of embryonic globin gene expression in adult erythroid cells. Molecular and Cellular Biology. 11: 4690-7. PMID 1875947 DOI: 10.1128/mcb.11.9.4690  0.65
Low-probability matches (unlikely to be authored by this person)
2020 Noomuna P, Risinger M, Zhou S, Seu K, Man Y, An R, Sheik DA, Wan J, Little JA, Gurkan UA, Turrini FM, Kalfa T, Low PS. Inhibition of Band 3 tyrosine phosphorylation: a new mechanism for treatment of sickle cell disease. British Journal of Haematology. PMID 32346864 DOI: 10.1111/Bjh.16671  0.299
2020 Hasan MN, Fraiwan A, An R, Alapan Y, Ung R, Akkus A, Xu JZ, Rezac AJ, Kocmich NJ, Creary MS, Oginni T, Olanipekun GM, Hassan-Hanga F, Jibir BW, Gambo S, ... ... Little JA, et al. Paper-based microchip electrophoresis for point-of-care hemoglobin testing. The Analyst. PMID 32123889 DOI: 10.1039/C9An02250C  0.294
2019 Fraiwan A, Hasan MN, An R, Xu JZ, Rezac AJ, Kocmich NJ, Oginni T, Olanipekun GM, Hassan-Hanga F, Jibir BW, Gambo S, Verma AK, Bharti PK, Riolueang S, Ngimhung T, ... ... Little JA, et al. International Multi-Site Clinical Validation of Point-of-Care Microchip Electrophoresis Test for Hemoglobin Variant Identification Blood. 134: 3373-3373. DOI: 10.1182/Blood-2019-129336  0.288
2019 Williams E, Brown E, Manwani D, Desai P, Field JJ, Neumayr LD, Padrino S, Clay ELJ, Cong Z, Agodoa I, Hoppe C, Lanzkron SM, Little JA. Chronic Kidney Disease Is Under-Screened in SCD and Mild Albuminuria Is Associated with a Drop in Hemoglobin: A Report from the Grndad Sickle Cell Registry Blood. 134: 2284-2284. DOI: 10.1182/Blood-2019-124933  0.285
2012 Breda L, Casu C, Gardenghi S, Bianchi N, Cartegni L, Narla M, Yazdanbakhsh K, Musso M, Manwani D, Little J, Gardner LB, Kleinert DA, Prus E, Fibach E, Grady RW, et al. Therapeutic hemoglobin levels after gene transfer in β-thalassemia mice and in hematopoietic cells of β-thalassemia and sickle cells disease patients. Plos One. 7: e32345. PMID 22479321 DOI: 10.1371/Journal.Pone.0032345  0.284
2020 Kanter J, Smith WR, Desai PC, Treadwell M, Andemariam B, Little J, Nugent D, Claster S, Manwani DG, Baker J, Strouse JJ, Osunkwo I, Stewart RW, King A, Shook LM, et al. Building access to care in adult sickle cell disease: defining models of care, essential components, and economic aspects. Blood Advances. 4: 3804-3813. PMID 32785684 DOI: 10.1182/Bloodadvances.2020001743  0.271
2003 Dempsey NJ, Ojalvo LS, Wu DW, Little JA. Induction of an embryonic globin gene promoter by short-chain fatty acids. Blood. 102: 4214-22. PMID 12920040 DOI: 10.1182/blood-2002-12-3766  0.259
2018 Kapoor S, Little JA, Pecker LH. Advances in the Treatment of Sickle Cell Disease. Mayo Clinic Proceedings. PMID 30414734 DOI: 10.1016/j.mayocp.2018.08.001  0.25
2004 Bock A, Bliss RL, Matas A, Little JA. Human leukocyte antigen type as a risk factor for nonmelanomatous skin cancer in patients after renal transplantation. Transplantation. 78: 775-8. PMID 15371688 DOI: 10.1097/01.Tp.0000131666.17216.11  0.246
2016 Alapan Y, Kim C, Adhikari A, Gray KE, Gurkan-Cavusoglu E, Little JA, Gurkan UA. Sickle cell disease biochip: a functional red blood cell adhesion assay for monitoring sickle cell disease. Translational Research : the Journal of Laboratory and Clinical Medicine. PMID 27063958 DOI: 10.1016/J.Trsl.2016.03.008  0.238
2021 Gollamudi J, Sarvepalli S, Vadaparti Binf A, Alin T, Little JA, Nayak L. Venous Thromboembolism in Sickle Cell Disease is Associated with Neutrophilia. Hemoglobin. 1-8. PMID 33588667 DOI: 10.1080/03630269.2020.1869565  0.236
2023 An R, Man Y, Cheng K, Zhang T, Chen C, Wang F, Abdulla F, Kucukal E, Wulftange WJ, Goreke U, Bode A, Nayak LV, Vercellotti GM, Belcher JD, Little JA, et al. Sickle red blood cell-derived extracellular vesicles activate endothelial cells and enhance sickle red cell adhesion mediated by von Willebrand factor. British Journal of Haematology. PMID 36604837 DOI: 10.1111/bjh.18616  0.235
2020 Paulson RF, Hariharan S, Little J. Stress erythropoiesis: definitions and models for its study. Experimental Hematology. PMID 32750404 DOI: 10.1016/J.Exphem.2020.07.011  0.23
2018 Kucukal E, Ilich A, Key NS, Little JA, Gurkan UA. Red Blood Cell Adhesion to Heme-Activated Endothelial Cells Reflects Clinical Phenotype in Sickle Cell Disease. American Journal of Hematology. PMID 29905377 DOI: 10.1002/Ajh.25159  0.229
2018 Boye-Doe A, Little J. Red Blood Cell Adhesion in Adult Patients with Sickle Cell Disease, at Baseline and with Pain, Measured on SCD Biochip Microfluidic Assay Blood. 132: 2386-2386. DOI: 10.1182/blood-2018-99-115586  0.228
2020 Man Y, Kucukal E, An R, Bode A, Little JA, Gurkan UA. Standardized microfluidic assessment of red blood cell mediated microcapillary occlusion: association with clinical phenotype and hydroxyurea responsiveness in sickle cell disease. Microcirculation (New York, N.Y. : 1994). e12662. PMID 33025653 DOI: 10.1111/micc.12662  0.226
2018 Hambley BC, Abdul Rahman R, Reback M, O'Riordan MA, Langer N, Gilkeson RC, Ginwalla M, Little JA, Schilz R. Intracardiac or intrapulmonary shunts were present in at least 35% of adults with homozygous sickle cell disease followed in an outpatient clinic. Haematologica. PMID 30006446 DOI: 10.3324/haematol.2018.196212  0.223
2021 Lanzkron S, Little J, Wang H, Field JJ, Shows JR, Haywood C, Saheed M, Proudford M, Robertson D, Kincaid A, Burgess L, Green C, Seufert R, Brooks J, Piehet A, et al. Treatment of Acute Pain in Adults With Sickle Cell Disease in an Infusion Center Versus the Emergency Department : A Multicenter Prospective Cohort Study. Annals of Internal Medicine. PMID 34224261 DOI: 10.7326/M20-7171  0.223
2023 Gonzalez Sepulveda JM, Yang JC, Reed SD, Lee TH, Ng X, Rosenberg SS, Irony T, Ho M, Rothman J, Badawy SM, Rowley C, Little J, Shah N, Li K, Telen MJ. Preferences for potential benefits and risks for gene therapy in the treatment of sickle cell disease. Blood Advances. PMID 37905989 DOI: 10.1182/bloodadvances.2023009680  0.214
2021 Desai P, Little J, Kanter J, Bridges K, Andemariam B, Lanzkron S. Kneeling Was the First Step for Sickle Cell Disease. Annals of Internal Medicine. PMID 33750189 DOI: 10.7326/M20-7418  0.212
2019 Yuan C, Quinn E, Kucukal E, Kapoor S, Gurkan UA, Little JA. Priapism, hemoglobin desaturation, and red blood cell adhesion in men with sickle cell anemia. Blood Cells, Molecules & Diseases. 79: 102350. PMID 31404907 DOI: 10.1016/J.Bcmd.2019.102350  0.212
2023 Goreke U, Iram S, Singh G, Domínguez-Medina S, Man Y, Bode A, An R, Little JA, Wirth CL, Hinczewski M, Gurkan UA. Catch bonds in sickle cell disease: shear-enhanced adhesion of red blood cells to laminin. Biophysical Journal. PMID 37177783 DOI: 10.1016/j.bpj.2023.05.010  0.209
2011 Quarta G, Quarta A, Melpignano A, Park LC, Lee HS, Shin SH, Im H, Ye BJ, Song MK, Oh SY, Kim H, Moon H, Hur M, Yun Y, Little J, et al. Subject Index Vol. 125, 2011 Acta Haematologica. 125: 248-248. DOI: 10.1159/000325163  0.202
2022 Wulftange WJ, Kucukal E, Man Y, An R, Monchamp K, Sevrain CD, Dashora HR, Owusu-Ansah AT, Bode A, Ilich A, Little JA, Key NS, Gurkan UA. Antithrombin-III mitigates thrombin-mediated endothelial cell contraction and sickle red blood cell adhesion in microscale flow. British Journal of Haematology. PMID 35822297 DOI: 10.1111/bjh.18328  0.19
2017 Rodgers-Melnick SN, Pell TJG, Lane D, Jenerette C, Fu P, Margevicius S, Little JA. The effects of music therapy on transition outcomes in adolescents and young adults with sickle cell disease. International Journal of Adolescent Medicine and Health. PMID 28779565 DOI: 10.1515/ijamh-2017-0004  0.187
2023 Obadina M, Wilson S, Derebail VK, Little J. Emerging Therapies and Advances in Sickle Cell Disease with a Focus on Renal Manifestations. Kidney360. PMID 37254256 DOI: 10.34067/KID.0000000000000162  0.186
2014 Alapan Y, Little JA, Gurkan UA. Heterogeneous red blood cell adhesion and deformability in sickle cell disease. Scientific Reports. 4: 7173. PMID 25417696 DOI: 10.1038/Srep07173  0.182
2022 Lanzkron S, Little J. Sickle Cell Disease: New Approaches for an Old Disease. Hematology/Oncology Clinics of North America. 36: xiii-xiv. PMID 36400546 DOI: 10.1016/j.hoc.2022.09.001  0.18
2011 Quarta G, Quarta A, Melpignano A, Park LC, Lee HS, Shin SH, Im H, Ye BJ, Song MK, Oh SY, Kim H, Moon H, Hur M, Yun Y, Little J, et al. Contents Vol. 125, 2011 Acta Haematologica. 125. DOI: 10.1159/000328029  0.178
2022 Lanzkron S, Manwani D, Desai P, Kanter J, Little J. GRNDaD: big data and sickle cell disease. Blood Advances. 6: 1088. PMID 35133406 DOI: 10.1182/bloodadvances.2021005282  0.174
2022 Man Y, Kucukal E, Liu S, An R, Goreke U, Wulftange WJ, Sekyonda Z, Bode A, Little JA, Manwani D, Stavrou EX, Gurkan UA. A microfluidic device for assessment of E-selectin-mediated neutrophil recruitment to inflamed endothelium and prediction of therapeutic response in sickle cell disease. Biosensors & Bioelectronics. 222: 114921. PMID 36521205 DOI: 10.1016/j.bios.2022.114921  0.173
2018 Gollamudi J, Al-Kindi S, Martin P, Little J, Nayak LV. Risk of Venous Thrombosis in Patients with Sickle Cell Trait after Orthopedic Surgery Blood. 132: 417-417. DOI: 10.1182/blood-2018-99-114353  0.172
2018 Lanzkron S, Little J, Field J, Shows JR, Wang H, Seufert R, Brooks J, Varadhan R, Haywood C, Saheed M, Huang CY, Griffin B, Frymark S, Piehet A, Robertson D, et al. Increased acute care utilization in a prospective cohort of adults with sickle cell disease. Blood Advances. 2: 2412-2417. PMID 30254105 DOI: 10.1182/Bloodadvances.2018018382  0.17
2022 Saraf SL, Derebail VK, Zhang X, Machado RF, Gordeuk VR, Lash JP, Little J. Hyperkalemia and Metabolic Acidosis Occur at a Higher eGFR in Sickle Cell Disease. Kidney360. 3: 608-614. PMID 35721605 DOI: 10.34067/KID.0006802021  0.164
2023 Goreke U, Kucukal E, Wang F, An R, Arnold N, Quinn EA, Yuan C, Bode A, Hill A, Man Y, Hambley BC, Schilz R, Ginwalla M, Little J, Gurkan UA. Membrane bending and sphingomyelinase associated sulfatide dependent hypoxic adhesion of sickle mature erythrocytes. Blood Advances. PMID 36652689 DOI: 10.1182/bloodadvances.2022008392  0.164
2016 Alapan Y, Fraiwan A, Kucukal E, Hasan MN, Ung R, Kim M, Odame I, Little JA, Gurkan UA. Emerging Point-of-Care Technologies for Sickle Cell Disease Screening and Monitoring. Expert Review of Medical Devices. PMID 27785945 DOI: 10.1080/17434440.2016.1254038  0.162
2022 Rodgers-Melnick SN, Lin L, Gam K, Souza de Santana Carvalho E, Jenerette C, Rowland DY, Little JA, Dusek JA, Bakshi N, Krishnamurti L. Effects of Music Therapy on Quality of Life in Adults with Sickle Cell Disease (MUSIQOLS): A Mixed Methods Feasibility Study. Journal of Pain Research. 15: 71-91. PMID 35046718 DOI: 10.2147/JPR.S337390  0.161
2021 Man Y, Maji D, An R, Ahuja SP, Little JA, Suster MA, Mohseni P, Gurkan UA. Microfluidic electrical impedance assessment of red blood cell-mediated microvascular occlusion. Lab On a Chip. PMID 33666615 DOI: 10.1039/d0lc01133a  0.16
2018 Donnola SB, Piccone CM, Lu L, Batesole J, Little J, Dell KM, Flask CA. Diffusion tensor imaging MRI of sickle cell kidney disease: initial results and comparison with iron deposition. Nmr in Biomedicine. PMID 29350437 DOI: 10.1002/Nbm.3883  0.16
2021 Ellsworth P, Little JA. Sevuparin trial for acute pain in sickle cell disease: the dog that did not bark. The Lancet. Haematology. 8: e307-e309. PMID 33894164 DOI: 10.1016/S2352-3026(21)00100-9  0.159
2019 Akkaya B, Kucukal E, Little JA, Gurkan UA. Mercury leads to abnormal red blood cell adhesion to laminin mediated by membrane sulfatides. Biochimica Et Biophysica Acta. Biomembranes. PMID 30890469 DOI: 10.1016/J.Bbamem.2019.03.008  0.158
2018 Rodgers-Melnick SN, Matthie N, Jenerette C, Griest Pell TJ, Lane D, Fu P, Margevicius S, Little JA. The Effects of a Single Electronic Music Improvisation Session on the Pain of Adults with Sickle Cell Disease: A Mixed Methods Pilot Study. Journal of Music Therapy. PMID 29796596 DOI: 10.1093/jmt/thy004  0.155
2018 Kucukal E, Little JA, Gurkan UA. Shear dependent red blood cell adhesion in microscale flow. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 29557482 DOI: 10.1039/C8Ib00004B  0.148
2017 Ginwalla M, AlMasoud A, Tofovic D, Alin T, Al-Kindi S, Oliveira G, Rajagopalan S, Schilz R, Little J. Cardiovascular Evaluation and Management of Iron Overload Cardiomyopathy in Sickle Cell Disease. American Journal of Hematology. PMID 28971490 DOI: 10.1002/ajh.24924  0.146
2016 Lanzkron S, Haywood C, Little JA, Field J, Shows JR, Segal J, Saheed M, Robertson D, Proudford MV, Kincaid A, Burgess L, Green C, Wang H, Seufert R, Brooks J, et al. Acute Care Utilization Is More Common in Patients with Sickle Cell Disease Who Have Chronic Complications and Chronic Pain: A Preliminary Report from the Escaped Trial Blood. 128: 2490-2490. DOI: 10.1182/Blood.V128.22.2490.2490  0.145
2017 Stehouwer N, Edge P, Park BK, Piccone C, Little J. Acute Pain in Adolescents and Young Adults with Sickle Cell Disease: Delayed and Increased Opioid Dosing Following Transition to Adult Care. American Journal of Hematology. PMID 28066934 DOI: 10.1002/ajh.24647  0.145
2021 An R, Man Y, Iram S, Kucukal E, Hasan MN, Huang Y, Goreke U, Bode A, Hill A, Cheng K, Sekyonda Z, Ahuja SP, Little JA, Hinczewski M, Gurkan UA. Point-of-care microchip electrophoresis for integrated anemia and hemoglobin variant testing. Lab On a Chip. PMID 34585199 DOI: 10.1039/d1lc00371b  0.144
2016 Rotz SJ, O'Riordan MA, Kim C, Langer N, Cruz C, Schilz R, Lance C, Little JA. Nocturnal hemoglobin desaturation is associated with reticulocytosis in adults with sickle cell disease and is independent of obstructive sleep apnea. American Journal of Hematology. PMID 27220489 DOI: 10.1002/ajh.24432  0.141
2017 Morrone KA, Pecker LH, Rand J, Davila J, Oyeku S, Little JA, Xiaonan X, Manwani D. Association of silent infarcts in sickle cell anemia with decreased annexin A5 resistance. Blood Cells, Molecules & Diseases. PMID 28911832 DOI: 10.1016/j.bcmd.2017.09.001  0.141
2021 Wilson SR, Sears M, Williams E, Drapekin J, Sivakumar I, Padrino S, Desai PC, Hager W, Manwani D, Clay LJ, Field JJ, Kanter J, Cohen AJ, Saif Ur Rehman S, Lanzkron S, ... Little JA, et al. Gaps in the diagnosis and management of iron overload in sickle cell disease: a 'real-world' report from the GRNDaD registry. British Journal of Haematology. PMID 34423416 DOI: 10.1111/bjh.17762  0.132
2023 Kenney MO, Wilson S, Shah N, Bortsov A, Smith WR, Little J, Lanzkron S, Kanter J, Padrino S, Owusu-Ansah A, Cohen A, Desai P, Manwani D, Rehman SSU, Hagar W, et al. Biopsychosocial Factors Associated with Pain and Pain-Related Outcomes in Adults and Children with Sickle Cell Disease: A Multivariable Analysis of the GRNDaD Multi-Center Registry. The Journal of Pain. PMID 37544393 DOI: 10.1016/j.jpain.2023.07.029  0.129
1982 Little JA, Dean AE, Chapman M. Immobilization hypercalcemia. Southern Medical Journal. 75: 502. PMID 7071652 DOI: 10.1097/00007611-198204000-00039  0.128
2009 Jain P, Cockwell P, Little J, Ferring M, Nicholas J, Richards N, Higgins R, Smith S. Survival and transplantation in end-stage renal disease: a prospective study of a multiethnic population. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. 24: 3840-6. PMID 19755474 DOI: 10.1093/ndt/gfp455  0.125
2023 Sparkenbaugh E, Little J. Cold comfort in sickle cell disease. Blood. 142: 1854-1856. PMID 38032675 DOI: 10.1182/blood.2023022621  0.12
2021 An R, Huang Y, Man Y, Valentine RW, Kucukal E, Goreke U, Sekyonda Z, Piccone C, Owusu-Ansah A, Ahuja S, Little JA, Gurkan UA. Emerging point-of-care technologies for anemia detection. Lab On a Chip. PMID 33881041 DOI: 10.1039/d0lc01235a  0.118
2015 Alkindi S, Almasoud A, Younes A, Elamm C, Benatti R, Oliveira G, Schilz R, Little J, Ginwalla M. Prevalence of Heart Failure in Different Sickle Cell Variants by Age, Gender, and Systolic Dysfunction Journal of Cardiac Failure. 21: S124-S125. DOI: 10.1016/j.cardfail.2015.06.358  0.113
2019 Ayache M, Rosen CL, Chiang A, Little JA, Strohl KP. Overnight oxygen desaturation index in sickle cell disease: prediction of sleep apnea. Sleep Medicine. 64: 12-14. PMID 31655319 DOI: 10.1016/j.sleep.2019.06.007  0.1
2017 Kim M, Alapan Y, Adhikari A, Little JA, Gurkan UA. Hypoxia enhanced adhesion of red blood cells in microscale flow. Microcirculation (New York, N.Y. : 1994). PMID 28387057 DOI: 10.1111/Micc.12374  0.095
2008 Taylor C, Cahill J, Gerrish M, Little J. A new haemodialysis catheter-locking agent reduces infections in haemodialysis patients. Journal of Renal Care. 34: 116-20. PMID 18786077 DOI: 10.1111/j.1755-6686.2008.00027.x  0.086
2019 Advani A, Cooper BW, Visconte V, Elson P, Chan R, Carew JS, Wei W, Mukherjee S, Gerds A, Carraway H, Nazha A, Hamilton B, Sobecks RM, Caimi PF, Tomlinson B, ... ... Little J, et al. A Phase 1/2 Trial of MEC (Mitoxantrone, Etoposide, Cytarabine) in Combination with Ixazomib for Relapsed/ Refractory Acute Myeloid Leukemia. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30992301 DOI: 10.1158/1078-0432.CCR-18-3886  0.077
2008 Jackson LD, Little J, Kung E, Williams EM, Siemiatkowska K, Plowman S. Safe medication swallowing in Dysphagia: a collaborative improvement project. Healthcare Quarterly (Toronto, Ont.). 11: 110-6. PMID 18382171  0.073
2004 Cosgriff P, Little J. Individual renal function based on 99mTc dimercaptosuccinic acid uptake corrected for renal size. Nuclear Medicine Communications. 25: 855-6; author reply . PMID 15266183  0.059
2022 Little JA. RBC, heal thyself: PK activators in SCD. Blood. 140: 2005-2006. PMID 36355466 DOI: 10.1182/blood.2022016930  0.05
2010 Potton E, Little J, Campbell J, Hind J, Corne J. The trainee-led clinicopathological conference: an innovative method for educating medical trainees. Clinical Medicine (London, England). 10: 34-6. PMID 20408303  0.011
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