Randall S. Johnson - Publications

Affiliations: 
Karolinska Institute, Stockholm, Sweden 

207 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Lambden S, Cowburn AS, Macias D, Garrud TAC, Krause BJ, Giussani DA, Summers C, Johnson RS. Endothelial cell regulation of systemic haemodynamics and metabolism acts through the HIF transcription factors. Intensive Care Medicine Experimental. 9: 28. PMID 34114090 DOI: 10.1186/s40635-021-00390-y  0.303
2020 Jing C, Castro-Dopico T, Richoz N, Tuong ZK, Ferdinand JR, Lok LSC, Loudon KW, Banham GD, Mathews RJ, Cader Z, Fitzpatrick S, Bashant KR, Kaplan MJ, Kaser A, Johnson RS, et al. Macrophage metabolic reprogramming presents a therapeutic target in lupus nephritis. Proceedings of the National Academy of Sciences of the United States of America. PMID 32541026 DOI: 10.1073/Pnas.2000943117  0.305
2019 Reiterer M, Colaço R, Emrouznejad P, Jensen A, Rundqvist H, Johnson RS, Branco C. Acute and chronic hypoxia differentially predispose lungs for metastases. Scientific Reports. 9: 10246. PMID 31308473 DOI: 10.1038/S41598-019-46763-Y  0.415
2018 Fitzpatrick SF, Gojkovic M, Macias D, Tegnebratt T, Lu L, Samén E, Rundqvist H, Johnson RS. Glycolytic Response to Inflammation Over Time: Role of Myeloid HIF-1alpha. Frontiers in Physiology. 9: 1624. PMID 30524296 DOI: 10.3389/Fphys.2018.01624  0.381
2018 Keränen MAI, Raissadati A, Nykänen AI, Dashkevich A, Tuuminen R, Krebs R, Johnson RS, Syrjälä SO, Lemström KB. Hypoxia-inducible factor controls immunoregulatory properties of myeloid cells in mouse cardiac allografts. Transplant International : Official Journal of the European Society For Organ Transplantation. PMID 29953680 DOI: 10.1111/Tri.13310  0.396
2018 Macias D, Cowburn AS, Torres-Torrelo H, Ortega-Sáenz P, López-Barneo J, Johnson R. Correction: HIF-2α is essential for carotid body development and function. Elife. 7. PMID 29863471 DOI: 10.7554/Elife.38781  0.3
2018 Macias D, Cowburn AS, Torres-Torrelo H, Ortega-Sáenz P, López-Barneo J, Johnson R. HIF-2α is essential for carotid body development and function. Elife. 7. PMID 29671738 DOI: 10.7554/Elife.34681  0.438
2018 Sim J, Cowburn AS, Palazon A, Madhu B, Tyrakis PA, Macías D, Bargiela DM, Pietsch S, Gralla M, Evans CE, Kittipassorn T, Chey YCJ, Branco CM, Rundqvist H, Peet DJ, ... Johnson RS, et al. The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia. Cell Metabolism. 27: 898-913.e7. PMID 29617647 DOI: 10.1016/J.Cmet.2018.02.020  0.365
2018 Macias D, Cowburn AS, Torres-Torrelo H, Ortega-Sáenz P, López-Barneo J, Johnson RS. Author response: HIF-2α is essential for carotid body development and function Elife. DOI: 10.7554/Elife.34681.023  0.314
2017 Palazon A, Tyrakis PA, Macias D, Veliça P, Rundqvist H, Fitzpatrick S, Vojnovic N, Phan AT, Loman N, Hedenfalk I, Hatschek T, Lövrot J, Foukakis T, Goldrath AW, Bergh J, ... Johnson RS, et al. An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression. Cancer Cell. 32: 669-683.e5. PMID 29136509 DOI: 10.1016/J.Ccell.2017.10.003  0.365
2017 Cowburn AS, Macias D, Summers C, Chilvers ER, Johnson RS. Cardiovascular adaptation to hypoxia and the role of peripheral resistance. Elife. 6. PMID 29049022 DOI: 10.7554/Elife.28755  0.388
2017 Horscroft JA, Kotwica AO, Laner V, West JA, Hennis PJ, Levett DZH, Howard DJ, Fernandez BO, Burgess SL, Ament Z, Gilbert-Kawai ET, Vercueil A, Landis BD, Mitchell K, Mythen MG, ... ... Johnson RS, et al. Metabolic basis to Sherpa altitude adaptation. Proceedings of the National Academy of Sciences of the United States of America. PMID 28533386 DOI: 10.1073/Pnas.1700527114  0.326
2017 Luecke-Johansson S, Gralla M, Rundqvist H, Ho JC, Johnson RS, Gradin K, Poellinger L. A molecular mechanism to switch the aryl hydrocarbon receptor from a transcription factor to an E3 ubiquitin ligase. Molecular and Cellular Biology. PMID 28416634 DOI: 10.1128/Mcb.00630-16  0.357
2017 Thompson AA, Dickinson RS, Murphy F, Thomson JP, Marriott HM, Tavares A, Willson J, Williams L, Lewis A, Mirchandani A, Dos Santos Coelho P, Doherty C, Ryan E, Watts E, Morton NM, ... ... Johnson RS, et al. Hypoxia determines survival outcomes of bacterial infection through HIF-1alpha dependent re-programming of leukocyte metabolism. Science Immunology. 2. PMID 28386604 DOI: 10.1126/Sciimmunol.Aal2861  0.336
2017 Evans CE, Palazon A, Sim J, Tyrakis PA, Prodger A, Lu X, Chan S, Bendahl PO, Belting M, Von Euler L, Rundqvist H, Johnson RS, Branco C. Modelling pulmonary microthrombosis coupled to metastasis: distinct effects of thrombogenesis on tumorigenesis. Biology Open. PMID 28302670 DOI: 10.1242/Bio.024653  0.337
2017 Cowburn A, Crosby A, Macias-Gutierrez D, Southwood M, Branco C, Morrell N, Chilvers E, Johnson R. S110 Hif2a deletion in the pulmonary endothelium prevents hypoxia-induced pulmonary hypertension Thorax. 72. DOI: 10.1136/Thoraxjnl-2017-210983.116  0.359
2016 Siebenmann C, Keramidas ME, Rundqvist H, Mijwel S, Cowburn AS, Johnson RS, Eiken O. Cutaneous exposure to hypoxia does not affect skin perfusion in humans. Acta Physiologica (Oxford, England). PMID 27809413 DOI: 10.1111/Apha.12825  0.317
2016 Tyrakis PA, Palazon A, Macias D, Lee KL, Phan AT, Veliça P, You J, Chia GS, Sim J, Doedens A, Abelanet A, Evans CE, Griffiths JR, Poellinger L, Goldrath AW, ... Johnson RS, et al. S-2-hydroxyglutarate regulates CD8(+) T-lymphocyte fate. Nature. PMID 27798602 DOI: 10.1038/Nature20165  0.329
2016 Yamamoto H, Rundqvist H, Branco C, Johnson RS. Autocrine VEGF Isoforms Differentially Regulate Endothelial Cell Behavior. Frontiers in Cell and Developmental Biology. 4: 99. PMID 27709112 DOI: 10.3389/Fcell.2016.00099  0.359
2016 Cowburn AS, Crosby A, Macias D, Branco C, Colaço RD, Southwood M, Toshner M, Crotty Alexander LE, Morrell NW, Chilvers ER, Johnson RS. HIF2α-arginase axis is essential for the development of pulmonary hypertension. Proceedings of the National Academy of Sciences of the United States of America. PMID 27432976 DOI: 10.1073/Pnas.1602978113  0.384
2016 Semba H, Takeda N, Isagawa T, Sugiura Y, Honda K, Wake M, Miyazawa H, Yamaguchi Y, Miura M, Jenkins DM, Choi H, Kim JW, Asagiri M, Cowburn AS, Abe H, ... ... Johnson RS, et al. HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity. Nature Communications. 7: 11635. PMID 27189088 DOI: 10.1038/Ncomms11635  0.361
2016 Branco C, Rundqvist H, Colaco R, Johnson RS. Abstract PR03: Hypoxia preconditioning affects metastatic seeding and proliferation through vascular and immune function, in a process regulated by lung endothelial HIFa Cancer Research. 76. DOI: 10.1158/1538-7445.Tummet15-Pr03  0.436
2016 Evans CE, Palazon A, Sim J, Tyrakis PA, Bendahl P, Belting M, Rundqvist H, Branco C, Johnson RS. Abstract A19: Pulmonary microthrombosis enhances tumorigenesis via myeloid hypoxia-inducible factors Cancer Research. 76. DOI: 10.1158/1538-7445.Tummet15-A19  0.373
2016 Gojkovic M, Rundqvist H, Veliça P, Johnson RS. Abstract C10: The role of FIH in macrophage function Cancer Research. 76. DOI: 10.1158/1538-7445.Tme16-C10  0.406
2016 Velica P, Rundqvist H, Gojkovic M, Johnson RS. Abstract A12: The immune composition of a spontaneous mouse breast cancer Cancer Research. 76. DOI: 10.1158/1538-7445.Tme16-A12  0.308
2016 Dickinson R, Thompson A, Thomson J, Murphy F, Marriott H, Tavares A, Willson J, Williams L, Lewis A, Forbes S, Stimson R, Hameed A, Preston J, Lawrie A, Finisguerra V, ... ... Johnson R, et al. S104 Hypoxia preconditions the innate immune response to acute bacterial pulmonary infections Thorax. 71: A61.2-A62. DOI: 10.1136/Thoraxjnl-2016-209333.110  0.336
2015 Evans CE, Bendahl PO, Belting M, Branco C, Johnson RS. Diverse roles of cell-specific hypoxia-inducible factor 1 in cancer-associated hypercoagulation. Blood. PMID 26702059 DOI: 10.1182/Blood-2015-09-671982  0.385
2015 Hong J, Tobin NP, Rundqvist H, Li T, Lavergne M, García-Ibáñez Y, Qin H, Paulsson J, Zeitelhofer M, Adzemovic MZ, Nilsson I, Roswall P, Hartman J, Johnson RS, Östman A, et al. Role of Tumor Pericytes in the Recruitment of Myeloid-Derived Suppressor Cells. Journal of the National Cancer Institute. 107. PMID 26296362 DOI: 10.1093/Jnci/Djv209  0.312
2015 Guimarães-Camboa N, Stowe J, Aneas I, Sakabe N, Cattaneo P, Henderson L, Kilberg MS, Johnson RS, Chen J, McCulloch AD, Nobrega MA, Evans SM, Zambon AC. HIF1α Represses Cell Stress Pathways to Allow Proliferation of Hypoxic Fetal Cardiomyocytes. Developmental Cell. 33: 507-21. PMID 26028220 DOI: 10.1016/J.Devcel.2015.04.021  0.337
2015 Koh HS, Chang CY, Jeon SB, Yoon HJ, Ahn YH, Kim HS, Kim IH, Jeon SH, Johnson RS, Park EJ. The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia. Nature Communications. 6: 6340. PMID 25790768 DOI: 10.1038/Ncomms7340  0.385
2015 Kalucka J, Schley G, Georgescu A, Klanke B, Rössler S, Baumgartl J, Velden J, Amann K, Willam C, Johnson RS, Eckardt KU, Weidemann A. Kidney injury is independent of endothelial HIF-1α Journal of Molecular Medicine (Berlin, Germany). PMID 25754172 DOI: 10.1007/S00109-015-1264-4  0.371
2015 Ashmore T, Fernandez BO, Evans CE, Huang Y, Branco-Price C, Griffin JL, Johnson RS, Feelisch M, Murray AJ. Suppression of erythropoiesis by dietary nitrate. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 29: 1102-12. PMID 25422368 DOI: 10.1096/Fj.14-263004  0.358
2015 Branco-Price C, Palazon A, Xie J, Johnson RS. Abstract B12: Molecular mechanisms of HIF-1a and HIF-2a activation in nonmalignant cells at the premetastatic niche: Effects on metastatic success Cancer Research. 75. DOI: 10.1158/1538-7445.Chtme14-B12  0.382
2014 Palazon A, Goldrath AW, Nizet V, Johnson RS. HIF transcription factors, inflammation, and immunity. Immunity. 41: 518-28. PMID 25367569 DOI: 10.1016/J.Immuni.2014.09.008  0.394
2014 Sim J, Johnson RS. A whiter shade of gray: HIF and coordination of angiogenesis with postnatal myelination. Developmental Cell. 30: 116-7. PMID 25073152 DOI: 10.1016/J.Devcel.2014.07.003  0.32
2014 Paatero I, Seagroves TN, Vaparanta K, Han W, Jones FE, Johnson RS, Elenius K. Hypoxia-inducible factor-1α induces ErbB4 signaling in the differentiating mammary gland. The Journal of Biological Chemistry. 289: 22459-69. PMID 24966332 DOI: 10.1074/Jbc.M113.533497  0.425
2014 Lindholm ME, Fischer H, Poellinger L, Johnson RS, Gustafsson T, Sundberg CJ, Rundqvist H. Negative regulation of HIF in skeletal muscle of elite endurance athletes: a tentative mechanism promoting oxidative metabolism. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 307: R248-55. PMID 24898836 DOI: 10.1152/Ajpregu.00036.2013  0.343
2014 O'Reilly VC, Lopes Floro K, Shi H, Chapman BE, Preis JI, James AC, Chapman G, Harvey RP, Johnson RS, Grieve SM, Sparrow DB, Dunwoodie SL. Gene-environment interaction demonstrates the vulnerability of the embryonic heart. Developmental Biology. 391: 99-110. PMID 24657234 DOI: 10.1016/J.Ydbio.2014.03.005  0.511
2014 Thompson AA, Elks PM, Marriott HM, Eamsamarng S, Higgins KR, Lewis A, Williams L, Parmar S, Shaw G, McGrath EE, Formenti F, Van Eeden FJ, Kinnula VL, Pugh CW, Sabroe I, ... ... Johnson RS, et al. Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish. Blood. 123: 366-76. PMID 24196071 DOI: 10.1182/Blood-2013-05-500207  0.419
2014 Cowburn AS, Alexander LE, Southwood M, Nizet V, Chilvers ER, Johnson RS. Epidermal deletion of HIF-2α stimulates wound closure. The Journal of Investigative Dermatology. 134: 801-8. PMID 24037341 DOI: 10.1038/Jid.2013.395  0.372
2013 Branco-Price C, Evans CE, Johnson RS. Endothelial hypoxic metabolism in carcinogenesis and dissemination: HIF-A isoforms are a NO metastatic phenomenon. Oncotarget. 4: 2567-76. PMID 24318195 DOI: 10.18632/Oncotarget.1461  0.397
2013 Cowburn AS, Takeda N, Boutin AT, Kim JW, Sterling JC, Nakasaki M, Southwood M, Goldrath AW, Jamora C, Nizet V, Chilvers ER, Johnson RS. HIF isoforms in the skin differentially regulate systemic arterial pressure. Proceedings of the National Academy of Sciences of the United States of America. 110: 17570-5. PMID 24101470 DOI: 10.1073/Pnas.1306942110  0.784
2013 Doedens AL, Phan AT, Stradner MH, Fujimoto JK, Nguyen JV, Yang E, Johnson RS, Goldrath AW. Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen. Nature Immunology. 14: 1173-82. PMID 24076634 DOI: 10.1038/Ni.2714  0.395
2013 Miyauchi Y, Sato Y, Kobayashi T, Yoshida S, Mori T, Kanagawa H, Katsuyama E, Fujie A, Hao W, Miyamoto K, Tando T, Morioka H, Matsumoto M, Chambon P, Johnson RS, et al. HIF1α is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis. Proceedings of the National Academy of Sciences of the United States of America. 110: 16568-73. PMID 24023068 DOI: 10.1073/Pnas.1308755110  0.323
2013 Rundqvist H, Johnson RS. Tumour oxygenation: implications for breast cancer prognosis. Journal of Internal Medicine. 274: 105-12. PMID 23844914 DOI: 10.1111/Joim.12091  0.341
2013 Scheerer N, Dehne N, Stockmann C, Swoboda S, Baba HA, Neugebauer A, Johnson RS, Fandrey J. Myeloid hypoxia-inducible factor-1α is essential for skeletal muscle regeneration in mice. Journal of Immunology (Baltimore, Md. : 1950). 191: 407-14. PMID 23729446 DOI: 10.4049/Jimmunol.1103779  0.361
2013 Bhandari T, Olson J, Johnson RS, Nizet V. HIF-1α influences myeloid cell antigen presentation and response to subcutaneous OVA vaccination. Journal of Molecular Medicine (Berlin, Germany). 91: 1199-205. PMID 23686259 DOI: 10.1007/S00109-013-1052-Y  0.399
2013 Tsukada K, Tajima T, Hori S, Matsuura T, Johnson RS, Goda N, Suematsu M. Hypoxia-inducible factor-1 is a determinant of lobular structure and oxygen consumption in the liver. Microcirculation (New York, N.Y. : 1994). 20: 385-93. PMID 23252463 DOI: 10.1111/Micc.12033  0.423
2013 Crotty Alexander LE, Akong-Moore K, Feldstein S, Johansson P, Nguyen A, McEachern EK, Nicatia S, Cowburn AS, Olson J, Cho JY, Isaacs H, Johnson RS, Broide DH, Nizet V. Myeloid cell HIF-1α regulates asthma airway resistance and eosinophil function. Journal of Molecular Medicine (Berlin, Germany). 91: 637-44. PMID 23250618 DOI: 10.1007/S00109-012-0986-9  0.34
2013 Evans CE, Branco-Price C, Humphries J, Wadoodi A, Saha P, Kim J, Belting M, Smith A, Johnson RS. Abstract B7: Hypoxia-inducible factor 1 mediates thrombosis-associated cancer progression Cancer Research. 73. DOI: 10.1158/1538-7445.Tim2013-B7  0.361
2013 Crotty Alexander LE, Nicatia S, McEachern E, Johnson R, Broide DH, Nizet V. Hypoxia Inducible Factor (HIF) Alpha Subunits Modulate Eosinophil Migration, Oxidative Burst, and Degranulation Journal of Allergy and Clinical Immunology. 131: AB239. DOI: 10.1016/J.Jaci.2012.12.1517  0.382
2012 Huang Y, Lei L, Liu D, Jovin I, Russell R, Johnson RS, Di Lorenzo A, Giordano FJ. Normal glucose uptake in the brain and heart requires an endothelial cell-specific HIF-1α-dependent function. Proceedings of the National Academy of Sciences of the United States of America. 109: 17478-83. PMID 23047702 DOI: 10.1073/Pnas.1209281109  0.352
2012 Peng H, Kaplan N, Hamanaka RB, Katsnelson J, Blatt H, Yang W, Hao L, Bryar PJ, Johnson RS, Getsios S, Chandel NS, Lavker RM. microRNA-31/factor-inhibiting hypoxia-inducible factor 1 nexus regulates keratinocyte differentiation. Proceedings of the National Academy of Sciences of the United States of America. 109: 14030-4. PMID 22891326 DOI: 10.1073/Pnas.1111292109  0.346
2012 Evans CE, Branco-Price C, Johnson RS. HIF-mediated endothelial response during cancer progression. International Journal of Hematology. 95: 471-7. PMID 22562456 DOI: 10.1007/S12185-012-1072-3  0.414
2012 Kim JW, Evans C, Weidemann A, Takeda N, Lee YS, Stockmann C, Branco-Price C, Brandberg F, Leone G, Ostrowski MC, Johnson RS. Loss of fibroblast HIF-1α accelerates tumorigenesis. Cancer Research. 72: 3187-95. PMID 22556263 DOI: 10.1158/0008-5472.Can-12-0534  0.377
2012 Meinecke AK, Nagy N, Lago GD, Kirmse S, Klose R, Schrödter K, Zimmermann A, Helfrich I, Rundqvist H, Theegarten D, Anhenn O, Orian-Rousseau V, Johnson RS, Alitalo K, Fischer JW, et al. Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis. Blood. 119: 5931-42. PMID 22547584 DOI: 10.1182/Blood-2011-12-396895  0.305
2012 Köhler T, Reizis B, Johnson RS, Weighardt H, Förster I. Influence of hypoxia-inducible factor 1α on dendritic cell differentiation and migration. European Journal of Immunology. 42: 1226-36. PMID 22539295 DOI: 10.1002/Eji.201142053  0.347
2012 Okumura CY, Hollands A, Tran DN, Olson J, Dahesh S, von Köckritz-Blickwede M, Thienphrapa W, Corle C, Jeung SN, Kotsakis A, Shalwitz RA, Johnson RS, Nizet V. A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection. Journal of Molecular Medicine (Berlin, Germany). 90: 1079-89. PMID 22371073 DOI: 10.1007/S00109-012-0882-3  0.361
2012 Branco-Price C, Zhang N, Schnelle M, Evans C, Katschinski DM, Liao D, Ellies L, Johnson RS. Endothelial cell HIF-1α and HIF-2α differentially regulate metastatic success. Cancer Cell. 21: 52-65. PMID 22264788 DOI: 10.1016/J.Ccr.2011.11.017  0.431
2012 Keith B, Johnson RS, Simon MC. HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression. Nature Reviews. Cancer. 12: 9-22. PMID 22169972 DOI: 10.1038/Nrc3183  0.403
2012 Nishiyama Y, Goda N, Kanai M, Niwa D, Osanai K, Yamamoto Y, Senoo-Matsuda N, Johnson RS, Miura S, Kabe Y, Suematsu M. HIF-1α induction suppresses excessive lipid accumulation in alcoholic fatty liver in mice. Journal of Hepatology. 56: 441-7. PMID 21896344 DOI: 10.1016/J.Jhep.2011.07.024  0.351
2012 Thompson A, Elks P, Marriott H, Higgins K, Parmar S, Shaw G, Eamsamarng S, McGrath E, Formenti F, Eeden FV, Kinnula V, Pugh C, Sabroe I, Dockrell D, Chilvers E, ... ... Johnson R, et al. T1 Hypoxia-Inducible Factor 2α Regulates Neutrophilic Inflammation in Humans, Mice and Zebrafish Thorax. 67: A1.1-A1. DOI: 10.1136/Thoraxjnl-2012-202678.001  0.38
2011 Kurihara T, Westenskow PD, Krohne TU, Aguilar E, Johnson RS, Friedlander M. Astrocyte pVHL and HIF-α isoforms are required for embryonic-to-adult vascular transition in the eye. The Journal of Cell Biology. 195: 689-701. PMID 22084310 DOI: 10.1083/Jcb.201107029  0.424
2011 Ochiai D, Goda N, Hishiki T, Kanai M, Senoo-Matsuda N, Soga T, Johnson RS, Yoshimura Y, Suematsu M. Disruption of HIF-1α in hepatocytes impairs glucose metabolism in diet-induced obesity mice. Biochemical and Biophysical Research Communications. 415: 445-9. PMID 22051049 DOI: 10.1016/J.Bbrc.2011.10.089  0.363
2011 Lin M, Chen Y, Jin J, Hu Y, Zhou KK, Zhu M, Le YZ, Ge J, Johnson RS, Ma JX. Ischaemia-induced retinal neovascularisation and diabetic retinopathy in mice with conditional knockout of hypoxia-inducible factor-1 in retinal Müller cells. Diabetologia. 54: 1554-66. PMID 21360191 DOI: 10.1007/S00125-011-2081-0  0.363
2011 Walmsley SR, Chilvers ER, Thompson AA, Vaughan K, Marriott HM, Parker LC, Shaw G, Parmar S, Schneider M, Sabroe I, Dockrell DH, Milo M, Taylor CT, Johnson RS, Pugh CW, et al. Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice. The Journal of Clinical Investigation. 121: 1053-63. PMID 21317538 DOI: 10.1172/Jci43273  0.429
2011 Stockmann C, Kirmse S, Helfrich I, Weidemann A, Takeda N, Doedens A, Johnson RS. A wound size-dependent effect of myeloid cell-derived vascular endothelial growth factor on wound healing. The Journal of Investigative Dermatology. 131: 797-801. PMID 21107350 DOI: 10.1038/Jid.2010.345  0.317
2011 Johnson RS. Physiology of HIF Regulation of Erythropoiesis Blood. 118. DOI: 10.1182/Blood.V118.21.Sci-38.Sci-38  0.376
2010 Mazumdar J, O'Brien WT, Johnson RS, LaManna JC, Chavez JC, Klein PS, Simon MC. O2 regulates stem cells through Wnt/β-catenin signalling. Nature Cell Biology. 12: 1007-13. PMID 20852629 DOI: 10.1038/Ncb2102  0.327
2010 Doedens AL, Stockmann C, Rubinstein MP, Liao D, Zhang N, DeNardo DG, Coussens LM, Karin M, Goldrath AW, Johnson RS. Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression. Cancer Research. 70: 7465-75. PMID 20841473 DOI: 10.1158/0008-5472.Can-10-1439  0.602
2010 Takubo K, Goda N, Yamada W, Iriuchishima H, Ikeda E, Kubota Y, Shima H, Johnson RS, Hirao A, Suematsu M, Suda T. Regulation of the HIF-1alpha level is essential for hematopoietic stem cells. Cell Stem Cell. 7: 391-402. PMID 20804974 DOI: 10.1016/J.Stem.2010.06.020  0.365
2010 Scott A, Powner MB, Gandhi P, Clarkin C, Gutmann DH, Johnson RS, Ferrara N, Fruttiger M. Astrocyte-derived vascular endothelial growth factor stabilizes vessels in the developing retinal vasculature. Plos One. 5: e11863. PMID 20686684 DOI: 10.1371/Journal.Pone.0011863  0.316
2010 Weidemann A, Krohne TU, Aguilar E, Kurihara T, Takeda N, Dorrell MI, Simon MC, Haase VH, Friedlander M, Johnson RS. Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retina. Glia. 58: 1177-85. PMID 20544853 DOI: 10.1002/Glia.20997  0.416
2010 Branco-Price C, Johnson RS. Tumor vessels are Eph-ing complicated. Cancer Cell. 17: 533-4. PMID 20541698 DOI: 10.1016/J.Ccr.2010.05.020  0.337
2010 Zhang N, Fu Z, Linke S, Chicher J, Gorman JJ, Visk D, Haddad GG, Poellinger L, Peet DJ, Powell F, Johnson RS. The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism. Cell Metabolism. 11: 364-78. PMID 20399150 DOI: 10.1016/J.Cmet.2010.03.001  0.388
2010 Wan C, Shao J, Gilbert SR, Riddle RC, Long F, Johnson RS, Schipani E, Clemens TL. Role of HIF-1alpha in skeletal development. Annals of the New York Academy of Sciences. 1192: 322-6. PMID 20392254 DOI: 10.1111/J.1749-6632.2009.05238.X  0.377
2010 Kurihara T, Kubota Y, Ozawa Y, Takubo K, Noda K, Simon MC, Johnson RS, Suematsu M, Tsubota K, Ishida S, Goda N, Suda T, Okano H. von Hippel-Lindau protein regulates transition from the fetal to the adult circulatory system in retina. Development (Cambridge, England). 137: 1563-71. PMID 20388654 DOI: 10.1242/Dev.049015  0.415
2010 Seagroves TN, Peacock DL, Liao D, Schwab LP, Krueger R, Handorf CR, Haase VH, Johnson RS. VHL deletion impairs mammary alveologenesis but is not sufficient for mammary tumorigenesis. The American Journal of Pathology. 176: 2269-82. PMID 20382704 DOI: 10.2353/Ajpath.2010.090310  0.404
2010 Takeda N, O'Dea EL, Doedens A, Kim JW, Weidemann A, Stockmann C, Asagiri M, Simon MC, Hoffmann A, Johnson RS. Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis. Genes & Development. 24: 491-501. PMID 20194441 DOI: 10.1101/Gad.1881410  0.405
2010 Stockmann C, Kerdiles Y, Nomaksteinsky M, Weidemann A, Takeda N, Doedens A, Torres-Collado AX, Iruela-Arispe L, Nizet V, Johnson RS. Loss of myeloid cell-derived vascular endothelial growth factor accelerates fibrosis. Proceedings of the National Academy of Sciences of the United States of America. 107: 4329-34. PMID 20142499 DOI: 10.1073/Pnas.0912766107  0.381
2010 Gibbons MA, Fitch PM, MacDuff A, Mackinnon AC, Forbes SJ, Aidinis V, Johnson RS, Sethi T, Haslett C, Rossi AG, Simpson AJ, Howie SEM, Hirani N. S124 Macrophage deletion of vHL results in alternative activation and enhanced lung fibrosis independent of HIF-1 Thorax. 65. DOI: 10.1136/Thx.2010.150946.25  0.337
2010 Keranen M, Krebs R, Johnson R, Nykanen A, Lemstrom K. 346: Constantly Stable Hypoxia Inducible Factor-1 in Myeloid Cells Prevents Acute Rejection in Mouse Cardiac Allografts The Journal of Heart and Lung Transplantation. 29: S116-S116. DOI: 10.1016/J.Healun.2009.11.359  0.341
2009 Weidemann A, Kerdiles YM, Knaup KX, Rafie CA, Boutin AT, Stockmann C, Takeda N, Scadeng M, Shih AY, Haase VH, Simon MC, Kleinfeld D, Johnson RS. The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice. The Journal of Clinical Investigation. 119: 3373-83. PMID 19809162 DOI: 10.1172/Jci39378  0.796
2009 Nizet V, Johnson RS. Interdependence of hypoxic and innate immune responses. Nature Reviews. Immunology. 9: 609-17. PMID 19704417 DOI: 10.1038/Nri2607  0.367
2009 Tajima T, Goda N, Fujiki N, Hishiki T, Nishiyama Y, Senoo-Matsuda N, Shimazu M, Soga T, Yoshimura Y, Johnson RS, Suematsu M. HIF-1alpha is necessary to support gluconeogenesis during liver regeneration. Biochemical and Biophysical Research Communications. 387: 789-94. PMID 19643083 DOI: 10.1016/J.Bbrc.2009.07.115  0.333
2009 Kim JW, Johnson RS. You don't need a PHD to grow a tumor. Developmental Cell. 16: 781-2. PMID 19531349 DOI: 10.1016/J.Devcel.2009.06.001  0.377
2009 Fang HY, Hughes R, Murdoch C, Coffelt SB, Biswas SK, Harris AL, Johnson RS, Imityaz HZ, Simon MC, Fredlund E, Greten FR, Rius J, Lewis CE. Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Blood. 114: 844-59. PMID 19454749 DOI: 10.1182/Blood-2008-12-195941  0.438
2009 Weidemann A, Johnson RS. Nonrenal regulation of EPO synthesis. Kidney International. 75: 682-8. PMID 19165176 DOI: 10.1038/Ki.2008.687  0.371
2009 Garcia CM, Shui YB, Kamath M, DeVillar J, Johnson RS, Gerber HP, Ferrara N, Robinson ML, Beebe DC. The function of VEGF-A in lens development: formation of the hyaloid capillary network and protection against transient nuclear cataracts. Experimental Eye Research. 88: 270-6. PMID 18782574 DOI: 10.1016/J.Exer.2008.07.017  0.354
2008 Stockmann C, Doedens A, Weidemann A, Zhang N, Takeda N, Greenberg JI, Cheresh DA, Johnson RS. Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis. Nature. 456: 814-8. PMID 18997773 DOI: 10.1038/Nature07445  0.354
2008 Greenberg JI, Shields DJ, Barillas SG, Acevedo LM, Murphy E, Huang J, Scheppke L, Stockmann C, Johnson RS, Angle N, Cheresh DA. A role for VEGF as a negative regulator of pericyte function and vessel maturation. Nature. 456: 809-13. PMID 18997771 DOI: 10.1038/Nature07424  0.329
2008 Chen Y, Doughman YQ, Gu S, Jarrell A, Aota S, Cvekl A, Watanabe M, Dunwoodie SL, Johnson RS, van Heyningen V, Kleinjan DA, Beebe DC, Yang YC. Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis. Development (Cambridge, England). 135: 2939-48. PMID 18653562 DOI: 10.1242/Dev.021097  0.329
2008 Shui YB, Arbeit JM, Johnson RS, Beebe DC. HIF-1: an age-dependent regulator of lens cell proliferation. Investigative Ophthalmology & Visual Science. 49: 4961-70. PMID 18586877 DOI: 10.1167/Iovs.08-2118  0.421
2008 Rankin EB, Rha J, Unger TL, Wu CH, Shutt HP, Johnson RS, Simon MC, Keith B, Haase VH. Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice. Oncogene. 27: 5354-8. PMID 18490920 DOI: 10.1038/Onc.2008.160  0.457
2008 Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson RS, Haddad GG, Karin M. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature. 453: 807-11. PMID 18432192 DOI: 10.1038/Nature06905  0.415
2008 Boutin AT, Weidemann A, Fu Z, Mesropian L, Gradin K, Jamora C, Wiesener M, Eckardt KU, Koch CJ, Ellies LG, Haddad G, Haase VH, Simon MC, Poellinger L, Powell FL, ... Johnson RS, et al. Epidermal sensing of oxygen is essential for systemic hypoxic response. Cell. 133: 223-34. PMID 18423195 DOI: 10.1016/J.Cell.2008.02.038  0.795
2008 Du R, Lu KV, Petritsch C, Liu P, Ganss R, Passegué E, Song H, Vandenberg S, Johnson RS, Werb Z, Bergers G. HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell. 13: 206-20. PMID 18328425 DOI: 10.1016/J.Ccr.2008.01.034  0.338
2008 Peyssonnaux C, Boutin AT, Zinkernagel AS, Datta V, Nizet V, Johnson RS. Critical role of HIF-1alpha in keratinocyte defense against bacterial infection. The Journal of Investigative Dermatology. 128: 1964-8. PMID 18323789 DOI: 10.1038/Jid.2008.27  0.781
2008 Lei L, Mason S, Liu D, Huang Y, Marks C, Hickey R, Jovin IS, Pypaert M, Johnson RS, Giordano FJ. Hypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau protein. Molecular and Cellular Biology. 28: 3790-803. PMID 18285456 DOI: 10.1128/Mcb.01580-07  0.347
2008 Zinkernagel AS, Peyssonnaux C, Johnson RS, Nizet V. Pharmacologic augmentation of hypoxia-inducible factor-1α with mimosine boosts the bactericidal capacity of phagocytes Journal of Infectious Diseases. 197: 214-217. PMID 18173364 DOI: 10.1086/524843  0.355
2007 Mason S, Johnson RS. The role of HIF-1 in hypoxic response in the skeletal muscle Advances in Experimental Medicine and Biology. 618: 229-244. PMID 18269201 DOI: 10.1007/978-0-387-75434-5_18  0.361
2007 Higgins DF, Kimura K, Bernhardt WM, Shrimanker N, Akai Y, Hohenstein B, Saito Y, Johnson RS, Kretzler M, Cohen CD, Eckardt KU, Iwano M, Haase VH. Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. The Journal of Clinical Investigation. 117: 3810-20. PMID 18037992 DOI: 10.1172/Jci30487  0.42
2007 Zinkernagel AS, Johnson RS, Nizet V. Hypoxia inducible factor (HIF) function in innate immunity and infection Journal of Molecular Medicine. 85: 1339-1346. PMID 18030436 DOI: 10.1007/S00109-007-0282-2  0.386
2007 Doedens A, Johnson RS. Transgenic Models to Understand Hypoxia-Inducible Factor Function Methods in Enzymology. 435: 87-105. PMID 17998050 DOI: 10.1016/S0076-6879(07)35005-2  0.473
2007 Amarilio R, Viukov SV, Sharir A, Eshkar-Oren I, Johnson RS, Zelzer E. HIF1alpha regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis. Development (Cambridge, England). 134: 3917-28. PMID 17913788 DOI: 10.1242/Dev.008441  0.408
2007 Mason SD, Rundqvist H, Papandreou I, Duh R, McNulty WJ, Howlett RA, Olfert IM, Sundberg CJ, Denko NC, Poellinger L, Johnson RS. HIF-1alpha in endurance training: suppression of oxidative metabolism. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 293: R2059-69. PMID 17855495 DOI: 10.1152/Ajpregu.00335.2007  0.384
2007 Bayele HK, Peyssonnaux C, Giatromanolaki A, Arrais-Silva WW, Mohamed HS, Collins H, Giorgio S, Koukourakis M, Johnson RS, Blackwell JM, Nizet V, Srai SK. HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA forming microsatellite. Blood. 110: 3039-48. PMID 17606764 DOI: 10.1182/Blood-2006-12-063289  0.34
2007 Liao D, Johnson RS. Hypoxia: A key regulator of angiogenesis in cancer Cancer and Metastasis Reviews. 26: 281-290. PMID 17603752 DOI: 10.1007/S10555-007-9066-Y  0.398
2007 Peyssonnaux C, Zinkernagel AS, Schuepbach RA, Rankin E, Vaulont S, Haase VH, Nizet V, Johnson RS. Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). The Journal of Clinical Investigation. 117: 1926-32. PMID 17557118 DOI: 10.1172/Jci31370  0.327
2007 Baranova O, Miranda LF, Pichiule P, Dragatsis I, Johnson RS, Chavez JC. Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 6320-32. PMID 17554006 DOI: 10.1523/Jneurosci.0449-07.2007  0.398
2007 Wang Y, Wan C, Deng L, Liu X, Cao X, Gilbert SR, Bouxsein ML, Faugere MC, Guldberg RE, Gerstenfeld LC, Haase VH, Johnson RS, Schipani E, Clemens TL. The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development. The Journal of Clinical Investigation. 117: 1616-26. PMID 17549257 DOI: 10.1172/Jci31581  0.387
2007 Peyssonnaux C, Cejudo-Martin P, Doedens A, Zinkernagel AS, Johnson RS, Nizet V. Cutting edge: Essential role of hypoxia inducible factor-1α in development of lipopolysaccharide-induced sepsis Journal of Immunology. 178: 7516-7519. PMID 17548584 DOI: 10.4049/Jimmunol.178.12.7516  0.336
2007 Provot S, Zinyk D, Gunes Y, Kathri R, Le Q, Kronenberg HM, Johnson RS, Longaker MT, Giaccia AJ, Schipani E. Hif-1alpha regulates differentiation of limb bud mesenchyme and joint development. The Journal of Cell Biology. 177: 451-64. PMID 17470636 DOI: 10.1083/Jcb.200612023  0.417
2007 Johnson RS, Huang LE. Can irradiated tumors take NO for an answer? Molecular Cell. 26: 157-8. PMID 17466616 DOI: 10.1016/J.Molcel.2007.04.008  0.364
2007 Rempe DA, Lelli KM, Vangeison G, Johnson RS, Federoff HJ. In cultured astrocytes, p53 and MDM2 do not alter hypoxia-inducible factor-1alpha function regardless of the presence of DNA damage. The Journal of Biological Chemistry. 282: 16187-201. PMID 17420250 DOI: 10.1074/Jbc.M702203200  0.382
2007 Boutin AT, Johnson RS. Waiting to Inhale: HIF-1 Modulates Aerobic Respiration Cell. 129: 29-30. PMID 17418782 DOI: 10.1016/J.Cell.2007.03.031  0.771
2007 Rankin EB, Biju MP, Liu Q, Unger TL, Rha J, Johnson RS, Simon MC, Keith B, Haase VH. Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. The Journal of Clinical Investigation. 117: 1068-77. PMID 17404621 DOI: 10.1172/Jci30117  0.433
2007 Blouw B, Haase VH, Song H, Bergers G, Johnson RS. Loss of vascular endothelial growth factor expression reduces vascularization, but not growth, of tumors lacking the Von Hippel-Lindau tumor suppressor gene. Oncogene. 26: 4531-40. PMID 17297464 DOI: 10.1038/Sj.Onc.1210249  0.36
2007 Gruber M, Hu CJ, Johnson RS, Brown EJ, Keith B, Simon MC. Acute postnatal ablation of Hif-2alpha results in anemia. Proceedings of the National Academy of Sciences of the United States of America. 104: 2301-6. PMID 17284606 DOI: 10.1073/Pnas.0608382104  0.399
2007 Liao D, Corle C, Seagroves TN, Johnson RS. Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression. Cancer Research. 67: 563-72. PMID 17234764 DOI: 10.1158/0008-5472.Can-06-2701  0.392
2007 Park SK, Haase VH, Johnson RS. von Hippel Lindau tumor suppressor regulates hepatic glucose metabolism by controlling expression of glucose transporter 2 and glucose 6-phosphatase. International Journal of Oncology. 30: 341-8. PMID 17203215 DOI: 10.3892/Ijo.30.2.341  0.359
2007 Lim JH, Park JW, Kim SJ, Kim MS, Park SK, Johnson RS, Chun YS. ATP6V0C competes with von Hippel-Lindau protein in hypoxia-inducible factor 1alpha (HIF-1alpha) binding and mediates HIF-1alpha expression by bafilomycin A1. Molecular Pharmacology. 71: 942-8. PMID 17178925 DOI: 10.1124/Mol.106.030296  0.386
2007 Weidemann A, Johnson RS. A wrinkle in the unfolding of hypoxic response: HIF and ATF4 Blood. 110: 3492-3493. DOI: 10.1182/Blood-2007-08-107888  0.388
2006 Allen JW, Khetani SR, Johnson RS, Bhatia SN. In vitro liver tissue model established from transgenic mice: role of HIF-1alpha on hypoxic gene expression. Tissue Engineering. 12: 3135-47. PMID 17518628 DOI: 10.1089/Ten.2006.12.3135  0.426
2006 Lim JH, Park JW, Kim MS, Park SK, Johnson RS, Chun YS. Bafilomycin induces the p21-mediated growth inhibition of cancer cells under hypoxic conditions by expressing hypoxia-inducible factor-1alpha. Molecular Pharmacology. 70: 1856-65. PMID 16940187 DOI: 10.1124/Mol.106.028076  0.408
2006 Tam BY, Wei K, Rudge JS, Hoffman J, Holash J, Park SK, Yuan J, Hefner C, Chartier C, Lee JS, Jiang S, Nayak NR, Niyak NR, Kuypers FA, Ma L, ... ... Johnson RS, et al. VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis. Nature Medicine. 12: 793-800. PMID 16799557 DOI: 10.1038/Nm1428  0.361
2006 Tang N, Mack F, Haase VH, Simon MC, Johnson RS. pVHL function is essential for endothelial extracellular matrix deposition. Molecular and Cellular Biology. 26: 2519-30. PMID 16537898 DOI: 10.1128/Mcb.26.7.2519-2530.2006  0.411
2006 Spear W, Chan D, Coppens I, Johnson RS, Giaccia A, Blader IJ. The host cell transcription factor hypoxia-inducible factor 1 is required for Toxoplasma gondii growth and survival at physiological oxygen levels. Cellular Microbiology. 8: 339-52. PMID 16441443 DOI: 10.1111/J.1462-5822.2005.00628.X  0.428
2005 Neumann AK, Yang J, Biju MP, Joseph SK, Johnson RS, Haase VH, Freedman BD, Turka LA. Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction. Proceedings of the National Academy of Sciences of the United States of America. 102: 17071-6. PMID 16286658 DOI: 10.1073/Pnas.0506070102  0.388
2005 Cejudo-Martin P, Johnson RS. A new Notch in the HIF belt: How hypoxia impacts differentiation Developmental Cell. 9: 575-576. PMID 16256731 DOI: 10.1016/J.Devcel.2005.10.001  0.349
2005 Peyssonnaux C, Datta V, Cramer T, Doedens A, Theodorakis EA, Gallo RL, Hurtado-Ziola N, Nizet V, Johnson RS. HIF-1alpha expression regulates the bactericidal capacity of phagocytes. The Journal of Clinical Investigation. 115: 1806-15. PMID 16007254 DOI: 10.1172/Jci23865  0.418
2005 Mialon A, Sankinen M, Söderström H, Junttila TT, Holmström T, Koivusalo R, Papageorgiou AC, Johnson RS, Hietanen S, Elenius K, Westermarck J. DNA topoisomerase I is a cofactor for c-Jun in the regulation of epidermal growth factor receptor expression and cancer cell proliferation. Molecular and Cellular Biology. 25: 5040-5051. PMID 15923621 DOI: 10.1128/Mcb.25.12.5040-5051.2005  0.341
2005 Helton R, Cui J, Scheel JR, Ellison JA, Ames C, Gibson C, Blouw B, Ouyang L, Dragatsis I, Zeitlin S, Johnson RS, Lipton SA, Barlow C. Brain-specific knock-out of hypoxia-inducible factor-1alpha reduces rather than increases hypoxic-ischemic damage. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 4099-107. PMID 15843612 DOI: 10.1523/Jneurosci.4555-04.2005  0.43
2005 Rankin EB, Higgins DF, Walisser JA, Johnson RS, Bradfield CA, Haase VH. Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice. Molecular and Cellular Biology. 25: 3163-72. PMID 15798202 DOI: 10.1128/Mcb.25.8.3163-3172.2005  0.448
2005 Xie L, Johnson RS, Freeman RS. Inhibition of NGF deprivation-induced death by low oxygen involves suppression of BIMEL and activation of HIF-1. The Journal of Cell Biology. 168: 911-20. PMID 15767462 DOI: 10.1083/Jcb.200407079  0.359
2005 Walmsley SR, Print C, Farahi N, Peyssonnaux C, Johnson RS, Cramer T, Sobolewski A, Condliffe AM, Cowburn AS, Johnson N, Chilvers ER. Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity. The Journal of Experimental Medicine. 201: 105-15. PMID 15630139 DOI: 10.1084/Jem.20040624  0.445
2005 Allen JW, Johnson RS, Bhatia SN. Hypoxic inhibition of 3-methylcholanthrene-induced CYP1A1 expression is independent of HIF-1alpha Toxicology Letters. 155: 151-159. PMID 15585370 DOI: 10.1016/J.Toxlet.2004.09.006  0.429
2004 Tang N, Wang L, Esko J, Giordano FJ, Huang Y, Gerber HP, Ferrara N, Johnson RS. Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell. 6: 485-95. PMID 15542432 DOI: 10.1016/J.Ccr.2004.09.026  0.419
2004 Karhausen J, Furuta GT, Tomaszewski JE, Johnson RS, Colgan SP, Haase VH. Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. The Journal of Clinical Investigation. 114: 1098-106. PMID 15489957 DOI: 10.1172/Jci21086  0.438
2004 Biju MP, Neumann AK, Bensinger SJ, Johnson RS, Turka LA, Haase VH. Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes. Molecular and Cellular Biology. 24: 9038-47. PMID 15456877 DOI: 10.1128/Mcb.24.20.9038-9047.2004  0.451
2004 Ogawa S, Lozach J, Jepsen K, Sawka-Verhelle D, Perissi V, Sasik R, Rose DW, Johnson RS, Rosenfeld MG, Glass CK. A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation. Proceedings of the National Academy of Sciences of the United States of America. 101: 14461-6. PMID 15452344 DOI: 10.1073/Pnas.0405786101  0.332
2004 Giaccia AJ, Simon MC, Johnson R. The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease. Genes & Development. 18: 2183-94. PMID 15371333 DOI: 10.1101/Gad.1243304  0.346
2004 Mason SD, Howlett RA, Kim MJ, Olfert IM, Hogan MC, McNulty W, Hickey RP, Wagner PD, Kahn CR, Giordano FJ, Johnson RS. Loss of skeletal muscle HIF-1alpha results in altered exercise endurance. Plos Biology. 2: e288. PMID 15328538 DOI: 10.1371/Journal.Pbio.0020288  0.35
2004 Higgins DF, Biju MP, Akai Y, Wutz A, Johnson RS, Haase VH. Hypoxic induction of Ctgf is directly mediated by Hif-1. American Journal of Physiology. Renal Physiology. 287: F1223-32. PMID 15315937 DOI: 10.1152/Ajprenal.00245.2004  0.457
2004 Cramer T, Schipani E, Johnson RS, Swoboda B, Pfander D. Expression of VEGF isoforms by epiphyseal chondrocytes during low-oxygen tension is HIF-1α dependent Osteoarthritis and Cartilage. 12: 433-439. PMID 15135139 DOI: 10.1016/J.Joca.2004.02.003  0.394
2004 Huang Y, Hickey RP, Yeh JL, Liu D, Dadak A, Young LH, Johnson RS, Giordano FJ. Cardiac myocyte-specific HIF-1alpha deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1138-40. PMID 15132980 DOI: 10.1096/Fj.04-1510Fje  0.362
2004 Pfander D, Kobayashi T, Knight MC, Zelzer E, Chan DA, Olsen BR, Giaccia AJ, Johnson RS, Haase VH, Schipani E. Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development. Development (Cambridge, England). 131: 2497-508. PMID 15128677 DOI: 10.1242/Dev.01138  0.408
2004 Kaufman B, Scharf O, Arbeit J, Ashcroft M, Brown JM, Bruick RK, Chapman JD, Evans SM, Giaccia AJ, Harris AL, Huang E, Johnson R, Kaelin W, Koch CJ, Maxwell P, et al. Proceedings of the Oxygen Homeostasis/Hypoxia Meeting. Cancer Research. 64: 3350-6. PMID 15126380 DOI: 10.1158/0008-5472.Can-03-2611  0.357
2004 Laderoute KR, Calaoagan JM, Knapp M, Johnson RS. Glucose Utilization Is Essential for Hypoxia-Inducible Factor 1α-Dependent Phosphorylation of c-Jun Molecular and Cellular Biology. 24: 4128-4137. PMID 15121835 DOI: 10.1128/Mcb.24.10.4128-4137.2004  0.408
2004 Poellinger L, Johnson RS. HIF-1 and hypoxic response: The plot thickens Current Opinion in Genetics and Development. 14: 81-85. PMID 15108809 DOI: 10.1016/J.Gde.2003.12.006  0.432
2004 Zelzer E, Mamluk R, Ferrara N, Johnson RS, Schipani E, Olsen BR. VEGFA is necessary for chondrocyte survival during bone development. Development (Cambridge, England). 131: 2161-71. PMID 15073147 DOI: 10.1242/Dev.01053  0.381
2004 Galijatovic A, Beaton D, Nguyen N, Chen S, Bonzo J, Johnson R, Maeda S, Karin M, Guengerich FP, Tukey RH. The human CYP1A1 gene is regulated in a developmental and tissue-specific fashion in transgenic mice. The Journal of Biological Chemistry. 279: 23969-76. PMID 15037607 DOI: 10.1074/Jbc.M400973200  0.321
2004 Peyssonaux C, Johnson RS. An unexpected role for hypoxic response: oxygenation and inflammation. Cell Cycle. 3: 168. DOI: 10.4161/Cc.3.2.687  0.303
2004 Tam BY, Hoffman J, Park S, Lee J, Sundram U, Wu G, Schrier SL, Johnson R, Mulligan R, Kuo CJ. Hypoxia-Independent Regulation of Hepatic Erythropoietin Production by Vascular Endothelial Growth Factor. Blood. 104: 2163-2163. DOI: 10.1182/Blood.V104.11.2163.2163  0.385
2003 Vengellur A, Woods BG, Ryan HE, Johnson RS, LaPres JJ. Gene expression profiling of the hypoxia signaling pathway in hypoxia-inducible factor 1alpha null mouse embryonic fibroblasts. Gene Expression. 11: 181-97. PMID 14686790 DOI: 10.3727/000000003108749062  0.474
2003 Giaccia A, Siim BG, Johnson RS. HIF-1 as a target for drug development. Nature Reviews. Drug Discovery. 2: 803-11. PMID 14526383 DOI: 10.1038/Nrd1199  0.382
2003 Goda N, Dozier SJ, Johnson RS. HIF-1 in cell cycle regulation, apoptosis, and tumor progression. Antioxidants & Redox Signaling. 5: 467-473. PMID 13678535 DOI: 10.1089/152308603768295212  0.434
2003 Blouw B, Song H, Tihan T, Bosze J, Ferrara N, Gerber HP, Johnson RS, Bergers G. The hypoxic response of tumors is dependent on their microenvironment. Cancer Cell. 4: 133-46. PMID 12957288 DOI: 10.1016/S1535-6108(03)00194-6  0.398
2003 Park SK, Dadak AM, Haase VH, Fontana L, Giaccia AJ, Johnson RS. Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha. Molecular and Cellular Biology. 23: 4959-71. PMID 12832481 DOI: 10.1128/Mcb.23.14.4959-4971.2003  0.414
2003 Unruh A, Ressel A, Mohamed HG, Johnson RS, Nadrowitz R, Richter E, Katschinski DM, Wenger RH. The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy. Oncogene. 22: 3213-20. PMID 12761491 DOI: 10.1038/Sj.Onc.1206385  0.441
2003 Cramer T, Johnson RS. A novel role for the hypoxia inducible transcription factor HIF-1alpha: critical regulation of inflammatory cell function Cell Cycle (Georgetown, Tex.). 2: 192-193. PMID 12734422  0.333
2003 Mihaylova VT, Bindra RS, Yuan J, Campisi D, Narayanan L, Jensen R, Giordano F, Johnson RS, Rockwell S, Glazer PM. Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells. Molecular and Cellular Biology. 23: 3265-73. PMID 12697826 DOI: 10.1128/Mcb.23.9.3265-3273.2003  0.377
2003 Cramer T, Yamanishi Y, Clausen BE, Förster I, Pawlinski R, Mackman N, Haase VH, Jaenisch R, Corr M, Nizet V, Firestein GS, Gerber HP, Ferrara N, Johnson RS. HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell. 112: 645-57. PMID 12628185 DOI: 10.1016/S0092-8674(03)00154-5  0.445
2003 Seagroves TN, Hadsell D, McManaman J, Palmer C, Liao D, McNulty W, Welm B, Wagner KU, Neville M, Johnson RS. HIF1α is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland Development. 130: 1713-1724. PMID 12620994 DOI: 10.1242/Dev.00403  0.402
2003 Goda N, Ryan HE, Khadivi B, McNulty W, Rickert RC, Johnson RS. Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia. Molecular and Cellular Biology. 23: 359-69. PMID 12482987 DOI: 10.1128/Mcb.23.1.359-369.2003  0.458
2003 Cramer T, Johnson RS. A novel role for the hypoxia inducible transcription factor HIF-1alpha: critical regulation of inflammatory cell function. Cell Cycle. 2: 192. DOI: 10.4161/Cc.2.3.402  0.442
2003 Pfander D, Cramer T, Schipani E, Johnson RS, Swoboda B. HIF-1alpha reguliert die Energiegewinnung und die Matrixsynthese von epiphysären Chondrozyten während Hypoxie Zeitschrift Fur Orthopadie Und Ihre Grenzgebiete. 141. DOI: 10.1055/S-2003-821829  0.333
2003 ALLEN J, JOHNSON R, BHATIA S. 235 Oxygen modulation of cytochrome P450 pathways: role of oxygen gradients and HIF-1alpha in hepatocytes in vitro Hepatology. 38: 270-270. DOI: 10.1016/S0270-9139(03)80278-1  0.36
2003 Cramer T, Yamanishi Y, Clausen BE, Förster I, Pawlinski R, Mackman N, Haase VH, Jaenisch R, Corr M, Nizet V, Firestein GS, Gerber HP, Ferrara N, Johnson RS. Erratum: HIF-1α is essential for myeloid cell-mediated inflammation (Cell 112:5 (648)) Cell. 113. DOI: 10.1016/S0092-8674(03)00311-8  0.347
2002 Palmada M, Kanwal S, Rutkoski NJ, Gustafson-Brown C, Johnson RS, Wisdom R, Carter BD, Gufstafson-Brown C. c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation. The Journal of Cell Biology. 158: 453-61. PMID 12163468 DOI: 10.1083/Jcb.200112129  0.304
2002 Seagroves T, Johnson RS. Two HIFs may be better than one Cancer Cell. 1: 211-213. PMID 12086854 DOI: 10.1016/S1535-6108(02)00048-X  0.373
2002 Laderoute KR, Calaoagan JM, Gustafson-Brown C, Knapp AM, Li GC, Mendonca HL, Ryan HE, Wang Z, Johnson RS. The response of c-jun/AP-1 to chronic hypoxia is hypoxia-inducible factor 1 alpha dependent. Molecular and Cellular Biology. 22: 2515-23. PMID 11909946 DOI: 10.1128/Mcb.22.8.2515-2523.2002  0.423
2002 Gupta VK, Jaskowiak NT, Beckett MA, Mauceri HJ, Grunstein J, Johnson RS, Calvin DA, Nodzenski E, Pejovic M, Kufe DW, Posner MC, Weichselbaum RR. Vascular endothelial growth factor enhances endothelial cell survival and tumor radioresistance. Cancer Journal (Sudbury, Mass.). 8: 47-54. PMID 11895203 DOI: 10.1097/00130404-200201000-00009  0.325
2002 Yun Z, Maecker HL, Johnson RS, Giaccia AJ. Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia. Developmental Cell. 2: 331-41. PMID 11879638 DOI: 10.1016/S1534-5807(02)00131-4  0.427
2002 Scheid A, Wenger RH, Schäffer L, Camenisch I, Distler O, Ferenc A, Cristina H, Ryan HE, Johnson RS, Wagner KF, Stauffer UG, Bauer C, Gassmann M, Meuli M. Physiologically low oxygen concentrations in fetal skin regulate hypoxia-inducible factor 1 and transforming growth factor-beta3. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 411-3. PMID 11790723 DOI: 10.1096/Fj.01-0496Fje  0.389
2001 Cao Y, Bonizzi G, Seagroves TN, Greten FR, Johnson R, Schmidt EV, Karin M. IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell. 107: 763-75. PMID 11747812 DOI: 10.1016/S0092-8674(01)00599-2  0.312
2001 Schipani E, Ryan HE, Didrickson S, Kobayashi T, Knight M, Johnson RS. Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival. Genes & Development. 15: 2865-76. PMID 11691837 DOI: 10.1101/Gad.934301  0.445
2001 Elson DA, Thurston G, Huang LE, Ginzinger DG, McDonald DM, Johnson RS, Arbeit JM. Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha. Genes & Development. 15: 2520-32. PMID 11581158 DOI: 10.1101/Gad.914801  0.441
2001 Mohanty S, Lee S, Yadava N, Dealy MJ, Johnson RS, Firtel RA. Regulated protein degradation controls PKA function and cell-type differentiation in Dictyostelium. Genes & Development. 15: 1435-48. PMID 11390363 DOI: 10.1101/Gad.871101  0.322
2001 Seagroves TN, Ryan HE, Lu H, Wouters BG, Knapp M, Thibault P, Laderoute K, Johnson RS. Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells. Molecular and Cellular Biology. 21: 3436-44. PMID 11313469 DOI: 10.1128/Mcb.21.10.3436-3444.2001  0.437
2001 Giordano FJ, Johnson RS. Angiogenesis: The role of the microenvironment in flipping the switch Current Opinion in Genetics and Development. 11: 35-40. PMID 11163148 DOI: 10.1016/S0959-437X(00)00153-2  0.378
2001 Kim M, Howlett R, Moore T, Wagner P, Johnson R. 533 Phenotypic expression in murine skeletal muscle: The impact of a tissue specific conditional knock-out of HIF-1α American Journal of Obstetrics and Gynecology. 185. DOI: 10.1016/S0002-9378(01)80565-2  0.302
2000 Grunstein J, Masbad JJ, Hickey R, Giordano F, Johnson RS. Isoforms of vascular endothelial growth factor act in a coordinate fashion To recruit and expand tumor vasculature. Molecular and Cellular Biology. 20: 7282-7291. PMID 10982845 DOI: 10.1128/Mcb.20.19.7282-7291.2000  0.382
2000 Tamura K, Sudo T, Senftleben U, Dadak AM, Johnson R, Karin M. Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell. 102: 221-31. PMID 10943842 DOI: 10.1016/S0092-8674(00)00027-1  0.324
2000 Makris C, Godfrey VL, Krähn-Senftleben G, Takahashi T, Roberts JL, Schwarz T, Feng L, Johnson RS, Karin M. Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti. Molecular Cell. 5: 969-79. PMID 10911991 DOI: 10.1016/S1097-2765(00)80262-2  0.326
2000 Garayoa M, Martínez A, Lee S, Pío R, An WG, Neckers L, Trepel J, Montuenga LM, Ryan H, Johnson R, Gassmann M, Cuttitta F. Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis. Molecular Endocrinology (Baltimore, Md.). 14: 848-62. PMID 10847587 DOI: 10.1210/Mend.14.6.0473  0.422
2000 Zundel W, Schindler C, Haas-Kogan D, Koong A, Kaper F, Chen E, Gottschalk AR, Ryan HE, Johnson RS, Jefferson AB, Stokoe D, Giaccia AJ. Loss of PTEN facilitates HIF-1-mediated gene expression. Genes & Development. 14: 391-6. PMID 10691731 DOI: 10.1101/Gad.14.4.391  0.432
2000 Xu Y, Ma M, Ippolito GC, Johnson RS, Szalai AJ, Spiegelman BM, Schroeder HW, Carroll MC, Volanakis JE. Activation of the alternative complement pathway in factor D-deficient mice Immunopharmacology. 49: 80. DOI: 10.1016/S0162-3109(00)80232-5  0.51
1999 Dealy MJ, Nguyen KV, Lo J, Gstaiger M, Krek W, Elson D, Arbeit J, Kipreos ET, Johnson RS. Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E. Nature Genetics. 23: 245-8. PMID 10508527 DOI: 10.1038/13886  0.304
1999 Li ZW, Chu W, Hu Y, Delhase M, Deerinck T, Ellisman M, Johnson R, Karin M. The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. The Journal of Experimental Medicine. 189: 1839-45. PMID 10359587 DOI: 10.1084/Jem.189.11.1839  0.331
1999 Hu Y, Baud V, Delhase M, Zhang P, Deerinck T, Ellisman M, Johnson R, Karin M. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase. Science (New York, N.Y.). 284: 316-20. PMID 10195896 DOI: 10.1126/Science.284.5412.316  0.316
1999 Wisdom R, Johnson RS, Moore C. c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms Embo Journal. 18: 188-197. PMID 9878062 DOI: 10.1093/Emboj/18.1.188  0.348
1998 Ryan HE, Lo J, Johnson RS. HIF-1 alpha is required for solid tumor formation and embryonic vascularization. The Embo Journal. 17: 3005-15. PMID 9606183 DOI: 10.1093/Emboj/17.11.3005  0.454
1997 Kash SF, Johnson RS, Tecott LH, Noebels JL, Mayfield RD, Hanahan D, Baekkeskov S. Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase. Proceedings of the National Academy of Sciences of the United States of America. 94: 14060-5. PMID 9391152 DOI: 10.1073/Pnas.94.25.14060  0.5
1996 Hotamisligil GS, Johnson RS, Distel RJ, Ellis R, Papaioannou VE, Spiegelman BM. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science (New York, N.Y.). 274: 1377-9. PMID 8910278 DOI: 10.1126/Science.274.5291.1377  0.627
1996 Honrado GI, Johnson RS, Golombek DA, Spiegelman BM, Papaioannou VE, Ralph MR. The circadian system of c-fos deficient mice. Journal of Comparative Physiology. a, Sensory, Neural, and Behavioral Physiology. 178: 563-70. PMID 8847666 DOI: 10.1007/Bf00190186  0.484
1996 Johnson R, Spiegelman B, Hanahan D, Wisdom R. Cellular transformation and malignancy induced by ras require c-jun Molecular and Cellular Biology. 16: 4504-4511. PMID 8754851 DOI: 10.1128/Mcb.16.8.4504  0.622
1996 Watanabe Y, Johnson RS, Butler LS, Binder DK, Spiegelman BM, Papaioannou VE, McNamara JO. Null mutation of c-fos impairs structural and functional plasticities in the kindling model of epilepsy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 3827-36. PMID 8656277 DOI: 10.1523/Jneurosci.16-12-03827.1996  0.311
1995 Vivanco MD, Johnson R, Galante PE, Hanahan D, Yamamoto KR. A transition in transcriptional activation by the glucocorticoid and retinoic acid receptors at the tumor stage of dermal fibrosarcoma development. The Embo Journal. 14: 2217-28. PMID 7774580 DOI: 10.1002/J.1460-2075.1995.Tb07216.X  0.554
1994 Jain J, Nalefski EA, McCaffrey PG, Johnson RS, Spiegelman BM, Papaioannou V, Rao A. Normal peripheral T-cell function in c-Fos-deficient mice. Molecular and Cellular Biology. 14: 1566-74. PMID 8114694 DOI: 10.1128/Mcb.14.3.1566  0.523
1994 Paylor R, Johnson RS, Papaioannou V, Spiegelman BM, Wehner JM. Behavioral assessment of c-fos mutant mice Brain Research. 651: 275-282. PMID 7922576 DOI: 10.1016/0006-8993(94)90707-2  0.467
1994 Hu E, Mueller E, Oliviero S, Papaioannou V, Johnson R, Spiegelman B. Targeted disruption of the c-fos gene demonstrates c-fos-dependent and -independent pathways for gene expression stimulated by growth factors or oncogenes. The Embo Journal. 13: 3094-3103. DOI: 10.1002/J.1460-2075.1994.Tb06608.X  0.549
1993 Johnson RS, van Lingen B, Papaioannou VE, Spiegelman BM. A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture. Genes & Development. 7: 1309-17. PMID 8330736 DOI: 10.1101/Gad.7.7B.1309  0.532
1992 Mombaerts P, Iacomini J, Johnson RS, Herrup K, Tonegawa S, Papaioannou VE. RAG-1-deficient mice have no mature B and T lymphocytes. Cell. 68: 869-77. PMID 1547488 DOI: 10.1016/0092-8674(92)90030-G  0.313
1992 Johnson RS, Spiegelman BM, Papaioannou V. Pleiotropic effects of a null mutation in the c-fos proto-oncogene Cell. 71: 577-586. PMID 1423615 DOI: 10.1016/0092-8674(92)90592-Z  0.517
1992 Field SJ, Johnson RS, Mortensen RM, Papaioannou VE, Spiegelman BM, Greenberg ME. Growth and differentiation of embryonic stem cells that lack an intact c-fos gene. Proceedings of the National Academy of Sciences of the United States of America. 89: 9306-10. PMID 1329091 DOI: 10.1073/Pnas.89.19.9306  0.524
1989 Johnson RS, Sheng M, Greenberg ME, Kolodner RD, Papaioannou VE, Spiegelman BM. Targeting of nonexpressed genes in embryonic stem cells via homologous recombination. Science (New York, N.Y.). 245: 1234-6. PMID 2506639 DOI: 10.1126/Science.2506639  0.521
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