Todd M Allen - Publications

Affiliations: 
Ragon Institute of MGH, MIT and Harvard 
Area:
HIV, HCV, immunotherapy, immunology, virology

223 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Joshi VR, Claiborne DT, Pack ML, Power KA, Newman RM, Batorsky R, Bean DJ, Goroff MS, Lingwood D, Seaman MS, Rosenberg E, Allen TM. A VRC13-like bNAb response is associated with complex escape pathways in HIV-1 envelope. Journal of Virology. e0172023. PMID 38412036 DOI: 10.1128/jvi.01720-23  0.346
2021 Calvet-Mirabent M, Claiborne DT, Deruaz M, Tanno S, Serra C, Delgado-Arévalo C, Sánchez-Cerrillo I, de Los Santos I, Sanz J, García-Fraile L, Sánchez-Madrid F, Alfranca A, Muñoz-Fernández MÁ, Allen TM, Buzón MJ, et al. Poly I:C and STING agonist-primed DC increase lymphoid tissue polyfunctional HIV-1-specific CD8 T cells and limit CD4 T cell loss in BLT mice. European Journal of Immunology. PMID 34935145 DOI: 10.1002/eji.202149502  0.389
2021 Collins DR, Urbach JM, Racenet ZJ, Arshad U, Power KA, Newman RM, Mylvaganam GH, Ly NL, Lian X, Rull A, Rassadkina Y, Yanez AG, Peluso MJ, Deeks SG, Vidal F, ... ... Allen TM, et al. Functional impairment of HIV-specific CD8 T cells precedes aborted spontaneous control of viremia. Immunity. PMID 34496223 DOI: 10.1016/j.immuni.2021.08.007  0.382
2021 Yates KB, Tonnerre P, Martin GE, Gerdemann U, Al Abosy R, Comstock DE, Weiss SA, Wolski D, Tully DC, Chung RT, Allen TM, Kim AY, Fidler S, Fox J, Frater J, et al. Epigenetic scars of CD8 T cell exhaustion persist after cure of chronic infection in humans. Nature Immunology. 22: 1020-1029. PMID 34312547 DOI: 10.1038/s41590-021-00979-1  0.316
2021 Tonnerre P, Wolski D, Subudhi S, Aljabban J, Hoogeveen RC, Damasio M, Drescher HK, Bartsch LM, Tully DC, Sen DR, Bean DJ, Brown J, Torres-Cornejo A, Robidoux M, Kvistad D, ... ... Allen TM, et al. Differentiation of exhausted CD8 T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory. Nature Immunology. 22: 1030-1041. PMID 34312544 DOI: 10.1038/s41590-021-00982-6  0.306
2021 Garcia-Beltran WF, Claiborne DT, Maldini CR, Phelps M, Vrbanac V, Karpel ME, Krupp KL, Power KA, Boutwell CL, Balazs AB, Tager AM, Altfeld M, Allen TM. Innate Immune Reconstitution in Humanized Bone Marrow-Liver-Thymus (HuBLT) Mice Governs Adaptive Cellular Immune Function and Responses to HIV-1 Infection. Frontiers in Immunology. 12: 667393. PMID 34122425 DOI: 10.3389/fimmu.2021.667393  0.396
2020 Offersen R, Yu WH, Scully EP, Julg B, Euler Z, Sadanand S, Garcia-Dominguez D, Zheng L, Rasmussen TA, Jennewein MF, Linde C, Sassic J, Lofano G, Vigano S, Stephenson KE, ... ... Allen T, et al. HIV Antibody Fc N-Linked Glycosylation Is Associated with Viral Rebound. Cell Reports. 33: 108502. PMID 33326789 DOI: 10.1016/j.celrep.2020.108502  0.302
2020 Maldini CR, Claiborne DT, Okawa K, Chen T, Dopkin DL, Shan X, Power KA, Trifonova RT, Krupp K, Phelps M, Vrbanac VD, Tanno S, Bateson T, Leslie GJ, Hoxie JA, ... ... Allen TM, et al. Dual CD4-based CAR T cells with distinct costimulatory domains mitigate HIV pathogenesis in vivo. Nature Medicine. PMID 32868878 DOI: 10.1038/S41591-020-1039-5  0.473
2020 Joshi VR, Newman RM, Pack ML, Power KA, Munro JB, Okawa K, Madani N, Sodroski JG, Schmidt AG, Allen TM. Gp41-targeted antibodies restore infectivity of a fusion-deficient HIV-1 envelope glycoprotein. Plos Pathogens. 16: e1008577. PMID 32392227 DOI: 10.1371/Journal.Ppat.1008577  0.464
2019 Claiborne DT, Dudek TE, Maldini CR, Power KA, Ghebremichael M, Seung E, Mellors EF, Vrbanac VD, Krupp K, Bisesi A, Tager AM, Knipe DM, Boutwell CL, Allen TM. Immunization of BLT Humanized Mice Redirects T Cell Responses to Gag and Reduces Acute HIV-1 Viremia. Journal of Virology. PMID 31375576 DOI: 10.1128/Jvi.00814-19  0.513
2019 Gaiha GD, Rossin EJ, Urbach J, Landeros C, Collins DR, Nwonu C, Muzhingi I, Anahtar MN, Waring OM, Piechocka-Trocha A, Waring M, Worrall DP, Ghebremichael MS, Newman RM, Power KA, ... Allen TM, et al. Structural topology defines protective CD8 T cell epitopes in the HIV proteome. Science (New York, N.Y.). 364: 480-484. PMID 31048489 DOI: 10.1126/Science.Aav5095  0.488
2019 Euler Z, VAN DEN Kerkhof TL, Kouyos RD, Tully DC, Allen TM, Trkola A, Sanders RW, Schuitemaker H, VAN Gils MJ. Lower Broadly Neutralizing Antibody Responses in Female Versus Male HIV-1 Infected Injecting Drug Users. Viruses. 11. PMID 31027215 DOI: 10.3390/V11040384  0.4
2019 Metsky HC, Siddle KJ, Gladden-Young A, Qu J, Yang DK, Brehio P, Goldfarb A, Piantadosi A, Wohl S, Carter A, Lin AE, Barnes KG, Tully DC, Corleis B, Hennigan S, ... ... Allen TM, et al. Capturing sequence diversity in metagenomes with comprehensive and scalable probe design. Nature Biotechnology. 37: 160-168. PMID 30718881 DOI: 10.1038/S41587-018-0006-X  0.312
2019 Usmani SM, Murooka TT, Deruaz M, Koh WH, Sharaf RR, Di Pilato M, Power KA, Lopez P, Hnatiuk R, Vrbanac VD, Tager AM, Allen TM, Luster AD, Mempel TR. HIV-1 Balances the Fitness Costs and Benefits of Disrupting the Host Cell Actin Cytoskeleton Early after Mucosal Transmission. Cell Host & Microbe. 25: 73-86.e5. PMID 30629922 DOI: 10.1016/J.Chom.2018.12.008  0.46
2019 Aljabban J, Tonnerre P, Kvistad D, Robidoux M, Brown J, Gustafson J, Chung RT, Allen T, Aneja J, Kim AY, Lauer GM. Sa1525 – Visne Analysis of Hepatitis C Virus-Specific Cd8 T Cells from Direct Acting Antiviral-Treated Chronic Hcv Patients and Hcv Resolvers Gastroenterology. 156. DOI: 10.1016/S0016-5085(19)40073-5  0.368
2018 Piantadosi A, Freije CA, Gosmann C, Ye S, Park D, Schaffner SF, Tully DC, Allen TM, Dong KL, Sabeti PC, Kwon DS. Metagenomic sequencing of HIV-1 in the blood and female genital tract reveals little quasispecies diversity during acute infection. Journal of Virology. PMID 30381486 DOI: 10.1128/Jvi.00804-18  0.441
2018 Martins MA, Tully DC, Pedreño-Lopez N, von Bredow B, Pauthner MG, Shin YC, Yuan M, Lima NS, Bean DJ, Gonzalez-Nieto L, Domingues A, Gutman MJ, Maxwell HS, Magnani DM, Ricciardi MJ, ... ... Allen TM, et al. + rhesus macaques vaccinated with , and manifest early control of SIVmac239 replication. Journal of Virology. PMID 29875239 DOI: 10.1128/Jvi.00690-18  0.642
2018 Brener J, Gall A, Hurst J, Batorsky R, Lavandier N, Chen F, Edwards A, Bolton C, Dsouza R, Allen T, Pybus OG, Kellam P, Matthews PC, Goulder PJR. Rapid HIV disease progression following superinfection in an HLA-B*27:05/B*57:01-positive transmission recipient. Retrovirology. 15: 7. PMID 29338738 DOI: 10.1186/S12977-018-0390-9  0.405
2017 Wolski D, Foote PK, Chen DY, Lewis-Ximenez LL, Fauvelle C, Aneja J, Walker A, Tonnerre P, Torres-Cornejo A, Kvistad D, Imam S, Waring MT, Tully DC, Allen TM, Chung RT, et al. Early Transcriptional Divergence Marks Virus-Specific Primary Human CD8(+) T Cells in Chronic versus Acute Infection. Immunity. 47: 648-663.e8. PMID 29045899 DOI: 10.1016/J.Immuni.2017.09.006  0.461
2017 Julg B, Sok D, Schmidt SD, Abbink P, Newman RM, Broge T, Linde C, Nkolola J, Le K, Su D, Torabi J, Pack M, Pegu A, Allen TM, Mascola JR, et al. Protective Efficacy of Broadly Neutralizing Antibodies with Incomplete Neutralization Activity Against SHIV in Rhesus Monkeys. Journal of Virology. PMID 28768869 DOI: 10.1128/Jvi.01187-17  0.402
2017 Magnani DM, Ricciardi MJ, Bailey VK, Gutman MJ, Pedreño-Lopez N, Silveira CGT, Maxwell HS, Domingues A, Gonzalez-Nieto L, Su Q, Newman RM, Pack M, Martins MA, Martinez-Navio JM, Fuchs SP, ... ... Allen TM, et al. Dengue Virus Evades AAV-Mediated Neutralizing Antibody Prophylaxis in Rhesus Monkeys. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 28750738 DOI: 10.1016/J.Ymthe.2017.06.020  0.549
2017 Martins MA, Tully DC, Shin YC, Gonzalez-Nieto L, Weisgrau K, Bean DJ, Gadgil R, Gutman MJ, Domingues A, Maxwell HS, Magnani D, Ricciardi M, Pedreño-Lopez N, Bailey V, Cruz M, ... ... Allen T, et al. Rare Control of SIVmac239 Infection in a Vaccinated Rhesus Macaque. Aids Research and Human Retroviruses. PMID 28503929 DOI: 10.1089/Aid.2017.0046  0.639
2017 Tully DC, Claiborne DT, Allen TM. Interferon-I: The Pièce de Résistance of HIV-1 Transmission? Trends in Microbiology. PMID 28285909 DOI: 10.1016/J.Tim.2017.02.010  0.443
2017 Corleis B, Lisanti AC, Körner C, Schiff AE, Rosenberg ES, Allen TM, Altfeld M, Kwon DS. Early type I Interferon response induces upregulation of human β-defensin 1 during acute HIV-1 infection. Plos One. 12: e0173161. PMID 28253319 DOI: 10.1371/Journal.Pone.0173161  0.463
2016 Jones RB, Mueller S, Kumari S, Vrbanac V, Genel S, Tager AM, Allen TM, Walker BD, Irvine DJ. Antigen recognition-triggered drug delivery mediated by nanocapsule-functionalized cytotoxic T-cells. Biomaterials. 117: 44-53. PMID 27936416 DOI: 10.1016/J.Biomaterials.2016.11.048  0.369
2016 Ranasinghe S, Lamothe PA, Soghoian DZ, Kazer SW, Cole MB, Shalek AK, Yosef N, Jones RB, Donaghey F, Nwonu C, Jani P, Clayton GM, Crawford F, White J, Montoya A, ... ... Allen TM, et al. Antiviral CD8(+) T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion. Immunity. 45: 917-930. PMID 27760342 DOI: 10.1016/J.Immuni.2016.09.015  0.501
2016 Hedegaard DL, Tully DC, Rowe IA, Reynolds GM, Bean DJ, Hu K, Davis C, Wilhelm A, Ogilvie CB, Power KA, Tarr AW, Kelly D, Allen TM, Balfe P, McKeating JA. High resolution sequencing of hepatitis C virus reveals limited intra-hepatic compartmentalization in end stage liver disease. Journal of Hepatology. PMID 27531641 DOI: 10.1016/J.Jhep.2016.07.048  0.364
2016 Deruaz M, Moldt B, Le KM, Power KA, Vrbanac VD, Tanno S, Ghebremichael MS, Allen TM, Tager AM, Burton DR, Luster AD. Protection of Humanized Mice From Repeated Intravaginal HIV Challenge by Passive Immunization: A Model for Studying the Efficacy of Neutralizing Antibodies In Vivo. The Journal of Infectious Diseases. PMID 27357340 DOI: 10.1093/Infdis/Jiw203  0.422
2016 Carlson JM, Du VY, Pfeifer N, Bansal A, Tan VY, Power K, Brumme CJ, Kreimer A, DeZiel CE, Fusi N, Schaefer M, Brockman MA, Gilmour J, Price MA, Kilembe W, ... ... Allen TM, et al. Impact of pre-adapted HIV transmission. Nature Medicine. PMID 27183217 DOI: 10.1038/Nm.4100  0.522
2016 Tully DC, Ogilvie CB, Batorsky RE, Bean DJ, Power KA, Ghebremichael M, Bedard HE, Gladden AD, Seese AM, Amero MA, Lane K, McGrath G, Bazner SB, Tinsley J, Lennon NJ, ... ... Allen TM, et al. Differences in the Selection Bottleneck between Modes of Sexual Transmission Influence the Genetic Composition of the HIV-1 Founder Virus. Plos Pathogens. 12: e1005619. PMID 27163788 DOI: 10.1371/Journal.Ppat.1005619  0.425
2016 Scully EP, Lockhart A, Garcia-Beltran W, Palmer CD, Musante C, Rosenberg E, Allen TM, Chang JJ, Bosch RJ, Altfeld M. Innate immune reconstitution with suppression of HIV-1. Jci Insight. 1: e85433. PMID 27158667 DOI: 10.1172/Jci.Insight.85433  0.444
2016 Tully DC, Hjerrild S, Leutscher PD, Renvillard SG, Ogilvie CB, Bean DJ, Videbech P, Allen TM, McKeating JA, Fletcher NF. Deep sequencing of hepatitis C virus reveals genetic compartmentalization in cerebrospinal fluid from cognitively impaired patients. Liver International : Official Journal of the International Association For the Study of the Liver. PMID 27045383 DOI: 10.1111/Liv.13134  0.338
2015 Palmer CD, Romero-Tejeda M, Sirignano M, Sharma S, Allen TM, Altfeld M, Jost S. Naturally Occurring Subclinical Endotoxemia in Humans Alters Adaptive and Innate Immune Functions through Reduced MAPK and Increased STAT1 Phosphorylation. Journal of Immunology (Baltimore, Md. : 1950). PMID 26643479 DOI: 10.4049/Jimmunol.1501888  0.386
2015 Walker A, Skibbe K, Steinmann E, Pfaender S, Kuntzen T, Megger DA, Groten S, Sitek B, Lauer GM, Kim AY, Pietschmann T, Allen TM, Timm J. Distinct escape pathway by HCV genotype 1a from a dominant CD8+ T cell response by selection of altered epitope processing. Journal of Virology. PMID 26446603 DOI: 10.1128/JVI.01993-15  0.456
2015 Rowe IA, Tully DC, Armstrong MJ, Parker R, Guo K, Barton D, Morse GD, Venuto CS, Ogilvie CB, Hedegaard DL, McKelvy JF, Wong-Staal F, Allen TM, Balfe P, McKeating JA, et al. Effect of scavenger receptor BI antagonist ITX5061 in patients with hepatitis C virus infection undergoing liver transplantation. Liver Transplantation : Official Publication of the American Association For the Study of Liver Diseases and the International Liver Transplantation Society. PMID 26437376 DOI: 10.1002/Lt.24349  0.332
2015 Martins MA, Tully DC, Cruz MA, Power KA, Veloso de Santana MG, Bean DJ, Ogilvie CB, Gadgil R, Lima NS, Magnani DM, Ejima K, Allison DB, Piatak M, Altman JD, Parks CL, ... ... Allen TM, et al. Vaccine-Induced Simian Immunodeficiency Virus-Specific CD8+ T-Cell Responses Focused on a Single Nef Epitope Select for Escape Variants Shortly after Infection. Journal of Virology. 89: 10802-20. PMID 26292326 DOI: 10.1128/Jvi.01440-15  0.646
2015 Brener J, Gall A, Batorsky R, Riddell L, Buus S, Leitman E, Kellam P, Allen T, Goulder P, Matthews PC. Disease progression despite protective HLA expression in an HIV-infected transmission pair. Retrovirology. 12: 55. PMID 26123575 DOI: 10.1186/S12977-015-0179-Z  0.439
2015 Karpel ME, Boutwell CL, Allen TM. BLT humanized mice as a small animal model of HIV infection. Current Opinion in Virology. 13: 75-80. PMID 26083316 DOI: 10.1016/J.Coviro.2015.05.002  0.443
2015 Sacks-Davis R, Grebely J, Dore GJ, Osburn W, Cox AL, Rice TM, Spelman T, Bruneau J, Prins M, Kim AY, McGovern BH, Shoukry NH, Schinkel J, Allen TM, Morris M, et al. Hepatitis C Virus Reinfection and Spontaneous Clearance of Reinfection-the InC3 Study. The Journal of Infectious Diseases. PMID 25883387 DOI: 10.1093/Infdis/Jiv220  0.354
2015 Brener J, Gall A, Batorsky R, Riddell L, Buus S, Leitman E, Kellam P, Allen T, Goulder P, Matthews PC. Disease progression despite protective HLA expression in an HIV-infected transmission pair Retrovirology. 12. DOI: 10.1186/s12977-015-0179-z  0.312
2014 Mandal PK, Ferreira LM, Collins R, Meissner TB, Boutwell CL, Friesen M, Vrbanac V, Garrison BS, Stortchevoi A, Bryder D, Musunuru K, Brand H, Tager AM, Allen TM, Talkowski ME, et al. Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9. Cell Stem Cell. 15: 643-52. PMID 25517468 DOI: 10.1016/J.Stem.2014.10.004  0.318
2014 Martin E, Carlson JM, Le AQ, Chopera DR, McGovern R, Rahman MA, Ng C, Jessen H, Kelleher AD, Markowitz M, Allen TM, Milloy MJ, Carrington M, Wainberg MA, Brumme ZL. Early immune adaptation in HIV-1 revealed by population-level approaches. Retrovirology. 11: 64. PMID 25212686 DOI: 10.1186/S12977-014-0064-1  0.463
2014 Körner C, Granoff ME, Amero MA, Sirignano MN, Vaidya SA, Jost S, Allen TM, Rosenberg ES, Altfeld M. Increased frequency and function of KIR2DL1-3⁺ NK cells in primary HIV-1 infection are determined by HLA-C group haplotypes. European Journal of Immunology. 44: 2938-48. PMID 25043727 DOI: 10.1002/Eji.201444751  0.439
2014 Carlson JM, Schaefer M, Monaco DC, Batorsky R, Claiborne DT, Prince J, Deymier MJ, Ende ZS, Klatt NR, DeZiel CE, Lin TH, Peng J, Seese AM, Shapiro R, Frater J, ... ... Allen TM, et al. HIV transmission. Selection bias at the heterosexual HIV-1 transmission bottleneck. Science (New York, N.Y.). 345: 1254031. PMID 25013080 DOI: 10.1126/Science.1254031  0.426
2014 Palmer CD, Tomassilli J, Sirignano M, Romero-Tejeda M, Arnold KB, Che D, Lauffenburger DA, Jost S, Allen T, Mayer KH, Altfeld M. Enhanced immune activation linked to endotoxemia in HIV-1 seronegative MSM. Aids (London, England). 28: 2162-6. PMID 25003719 DOI: 10.1097/Qad.0000000000000386  0.44
2014 Veerapu NS, Park SH, Tully DC, Allen TM, Rehermann B. Trace amounts of sporadically reappearing HCV RNA can cause infection. The Journal of Clinical Investigation. 124: 3469-78. PMID 25003189 DOI: 10.1172/Jci73104  0.326
2014 Vaidya SA, Korner C, Sirignano MN, Amero M, Bazner S, Rychert J, Allen TM, Rosenberg ES, Bosch RJ, Altfeld M. Tumor necrosis factor α is associated with viral control and early disease progression in patients with HIV type 1 infection. The Journal of Infectious Diseases. 210: 1042-6. PMID 24688071 DOI: 10.1093/Infdis/Jiu206  0.449
2014 Jessen H, Allen TM, Streeck H. How a single patient influenced HIV research--15-year follow-up. The New England Journal of Medicine. 370: 682-3. PMID 24521131 DOI: 10.1056/Nejmc1308413  0.387
2014 Nitschke K, Barriga A, Schmidt J, Timm J, Viazov S, Kuntzen T, Kim AY, Lauer GM, Allen TM, Gaudieri S, Rauch A, Lange CM, Sarrazin C, Eiermann T, Sidney J, et al. HLA-B*27 subtype specificity determines targeting and viral evolution of a hepatitis C virus-specific CD8+ T cell epitope. Journal of Hepatology. 60: 22-9. PMID 23978718 DOI: 10.1016/J.Jhep.2013.08.009  0.44
2014 Brener J, Gall A, Batorsky R, Kellam P, Allen T, Matthews P, Goulder P. HIV Minor Variants Detected by Next Generation Sequencing: Impact on Immune Control of HIV in the Context of HLA-B*27:05 and HLA-B*57:01 Aids Research and Human Retroviruses. 30. DOI: 10.1089/Aid.2014.5384.Abstract  0.421
2013 Vaidya SA, Streeck H, Beckwith N, Ghebremichael M, Pereyra F, Kwon DS, Addo MM, Rychert J, Routy JP, Jessen H, Kelleher AD, Hecht F, Sekaly RP, Carrington M, Walker BD, ... Allen TM, et al. Temporal effect of HLA-B*57 on viral control during primary HIV-1 infection. Retrovirology. 10: 139. PMID 24245727 DOI: 10.1186/1742-4690-10-139  0.475
2013 Seung E, Dudek TE, Allen TM, Freeman GJ, Luster AD, Tager AM. PD-1 blockade in chronically HIV-1-infected humanized mice suppresses viral loads. Plos One. 8: e77780. PMID 24204962 DOI: 10.1371/Journal.Pone.0077780  0.427
2013 Bartha I, Carlson JM, Brumme CJ, McLaren PJ, Brumme ZL, John M, Haas DW, Martinez-Picado J, Dalmau J, López-Galíndez C, Casado C, Rauch A, Günthard HF, Bernasconi E, Vernazza P, ... ... Allen TM, et al. A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control. Elife. 2: e01123. PMID 24171102 DOI: 10.7554/Elife.01123  0.395
2013 Dudek TE, Allen TM. HIV-specific CD8⁺ T-cell immunity in humanized bone marrow-liver-thymus mice. The Journal of Infectious Diseases. 208: S150-4. PMID 24151322 DOI: 10.1093/Infdis/Jit320  0.512
2013 Tager AM, Pensiero M, Allen TM. Recent advances in humanized mice: accelerating the development of an HIV vaccine. The Journal of Infectious Diseases. 208: S121-4. PMID 24151317 DOI: 10.1093/Infdis/Jit451  0.445
2013 Lavender KJ, Pang WW, Messer RJ, Duley AK, Race B, Phillips K, Scott D, Peterson KE, Chan CK, Dittmer U, Dudek T, Allen TM, Weissman IL, Hasenkrug KJ. BLT-humanized C57BL/6 Rag2-/-γc-/-CD47-/- mice are resistant to GVHD and develop B- and T-cell immunity to HIV infection. Blood. 122: 4013-20. PMID 24021673 DOI: 10.1182/Blood-2013-06-506949  0.45
2013 Youngblood B, Noto A, Porichis F, Akondy RS, Ndhlovu ZM, Austin JW, Bordi R, Procopio FA, Miura T, Allen TM, Sidney J, Sette A, Walker BD, Ahmed R, Boss JM, et al. Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells. Journal of Immunology (Baltimore, Md. : 1950). 191: 540-4. PMID 23772031 DOI: 10.4049/Jimmunol.1203161  0.443
2013 Boutwell CL, Carlson JM, Lin TH, Seese A, Power KA, Peng J, Tang Y, Brumme ZL, Heckerman D, Schneidewind A, Allen TM. Frequent and variable cytotoxic-T-lymphocyte escape-associated fitness costs in the human immunodeficiency virus type 1 subtype B Gag proteins. Journal of Virology. 87: 3952-65. PMID 23365420 DOI: 10.1128/Jvi.03233-12  0.415
2013 Ansari IuH, Allen T, Berical A, Stock PG, Barin B, Striker R. Phenotypic analysis of NS5A variant from liver transplant patient with increased cyclosporine susceptibility Virology. 436: 268-273. PMID 23290631 DOI: 10.1016/J.Virol.2012.11.018  0.321
2013 Newman RM, Kuntzen T, Weiner B, Berical A, Charlebois P, Kuiken C, Murphy DG, Simmonds P, Bennett P, Lennon NJ, Birren BW, Zody MC, Allen TM, Henn MR. Whole genome pyrosequencing of rare hepatitis C virus genotypes enhances subtype classification and identification of naturally occurring drug resistance variants. The Journal of Infectious Diseases. 208: 17-31. PMID 23136221 DOI: 10.1093/Infdis/Jis679  0.364
2013 Malboeuf CM, Yang X, Charlebois P, Qu J, Berlin AM, Casali M, Pesko KN, Boutwell CL, DeVincenzo JP, Ebel GD, Allen TM, Zody MC, Henn MR, Levin JZ. Complete viral RNA genome sequencing of ultra-low copy samples by sequence-independent amplification. Nucleic Acids Research. 41: e13. PMID 22962364 DOI: 10.1093/Nar/Gks794  0.336
2013 Bartha I, Carlson JM, Brumme CJ, McLaren PJ, Brumme ZL, John M, Haas DW, Martinez-Picado J, Dalmau J, López-Galíndez C, Casado C, Rauch A, Günthard HF, Bernasconi E, Vernazza P, ... ... Allen TM, et al. Author response: A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control Elife. DOI: 10.7554/Elife.01123.009  0.363
2013 Walker A, Skibbe K, Groten S, Lüger V, Ruhl M, Kuntzen T, Allen T, Timm J. CD8+ T cell escape of HCV by selection of a polymorphism in the epitope flanking region that impairs antigen processing and presentation Zeitschrift Fur Gastroenterologie. 51. DOI: 10.1055/S-0032-1332185  0.39
2012 Mudd PA, Martins MA, Ericsen AJ, Tully DC, Power KA, Bean AT, Piaskowski SM, Duan L, Seese A, Gladden AD, Weisgrau KL, Furlott JR, Kim YI, Veloso de Santana MG, Rakasz E, ... ... Allen TM, et al. Vaccine-induced CD8+ T cells control AIDS virus replication. Nature. 491: 129-33. PMID 23023123 DOI: 10.1038/Nature11443  0.658
2012 Dudek TE, No DC, Seung E, Vrbanac VD, Fadda L, Bhoumik P, Boutwell CL, Power KA, Gladden AD, Battis L, Mellors EF, Tivey TR, Gao X, Altfeld M, Luster AD, ... ... Allen TM, et al. Rapid evolution of HIV-1 to functional CD8⁺ T cell responses in humanized BLT mice. Science Translational Medicine. 4: 143ra98. PMID 22814851 DOI: 10.1126/Scitranslmed.3003984  0.477
2012 Chen H, Ndhlovu ZM, Liu D, Porter LC, Fang JW, Darko S, Brockman MA, Miura T, Brumme ZL, Schneidewind A, Piechocka-Trocha A, Cesa KT, Sela J, Cung TD, Toth I, ... ... Allen TM, et al. TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection. Nature Immunology. 13: 691-700. PMID 22683743 DOI: 10.1038/Ni.2342  0.516
2012 Thobakgale CF, Fadda L, Lane K, Toth I, Pereyra F, Bazner S, Ndung'u T, Walker BD, Rosenberg ES, Alter G, Carrington M, Allen TM, Altfeld M. Frequent and strong antibody-mediated natural killer cell activation in response to HIV-1 Env in individuals with chronic HIV-1 infection. Journal of Virology. 86: 6986-93. PMID 22496218 DOI: 10.1128/Jvi.00569-12  0.466
2012 Macalalad AR, Zody MC, Charlebois P, Lennon NJ, Newman RM, Malboeuf CM, Ryan EM, Boutwell CL, Power KA, Brackney DE, Pesko KN, Levin JZ, Ebel GD, Allen TM, Birren BW, et al. Highly sensitive and specific detection of rare variants in mixed viral populations from massively parallel sequence data. Plos Computational Biology. 8: e1002417. PMID 22438797 DOI: 10.1371/Journal.Pcbi.1002417  0.362
2012 Henn MR, Boutwell CL, Charlebois P, Lennon NJ, Power KA, Macalalad AR, Berlin AM, Malboeuf CM, Ryan EM, Gnerre S, Zody MC, Erlich RL, Green LM, Berical A, Wang Y, ... ... Allen TM, et al. Whole genome deep sequencing of HIV-1 reveals the impact of early minor variants upon immune recognition during acute infection. Plos Pathogens. 8: e1002529. PMID 22412369 DOI: 10.1371/Journal.Ppat.1002529  0.51
2012 Schulze Zur Wiesch J, Ciuffreda D, Lewis-Ximenez L, Kasprowicz V, Nolan BE, Streeck H, Aneja J, Reyor LL, Allen TM, Lohse AW, McGovern B, Chung RT, Kwok WW, Kim AY, Lauer GM. Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence. The Journal of Experimental Medicine. 209: 61-75. PMID 22213804 DOI: 10.1084/Jem.20100388  0.441
2012 Chang JJ, Lacas A, Lindsay RJ, Doyle EH, Axten KL, Pereyra F, Rosenberg ES, Walker BD, Allen TM, Altfeld M. Differential regulation of toll-like receptor pathways in acute and chronic HIV-1 infection. Aids (London, England). 26: 533-41. PMID 22210629 DOI: 10.1097/Qad.0B013E32834F3167  0.452
2012 Ruhl M, Chhatwal P, Strathmann H, Kuntzen T, Bankwitz D, Skibbe K, Walker A, Heinemann FM, Horn PA, Allen TM, Hoffmann D, Pietschmann T, Timm J. Escape from a dominant HLA-B*15-restricted CD8+ T cell response against hepatitis C virus requires compensatory mutations outside the epitope. Journal of Virology. 86: 991-1000. PMID 22072759 DOI: 10.1128/Jvi.05603-11  0.458
2012 Chen H, Ndhlovu Z, Liu D, Porter L, Fang J, Darko S, Brockman M, Miura T, Brumme Z, Schneidewind A, Piechocka-Trocha A, Cesa K, Sela J, Cung T, Toth I, ... ... Allen T, et al. T cell receptor clonotypes modulate the protective effect of human leukocyte antigen class I alleles in HIV-1 infection Retrovirology. 9. DOI: 10.1186/1742-4690-9-S2-P264  0.496
2012 Dudek T, No D, Seung E, Vrbanac V, Fadda L, Bryant K, Altfeld M, Luster A, Knipe D, Tager A, Allen T. Rapid evolution of HIV-1 to functional CD8+ T-cell rResponses in humanized BLT mice Retrovirology. 9: 249. DOI: 10.1186/1742-4690-9-S2-P249  0.43
2012 Buranapraditkun S, Hempel U, Hildebrand W, Allen T, Ruxrungtham K. The roles of HIV-1 specific CD8+ T cell responses and HLA class I alleles on viral control and viral escape in HIV-1 infected Thai individuals Retrovirology. 9: 248. DOI: 10.1186/1742-4690-9-S2-P248  0.479
2012 Deruaz M, Murooka T, Dudek TE, Vrbanac V, Tivet T, Bankert K, Allen T, Tager AM, Luster AD. The humanized BLT mouse to study HIV transmission. Retrovirology. 9: 197. DOI: 10.1186/1742-4690-9-S2-P197  0.418
2012 Thobakgale C, Fadda L, Lane K, Toth I, Pereyra F, Bazner S, Ndung'u T, Walker B, Rosenberg E, Alter G, Carrington M, Allen T, Altfeld M. Frequent and strong antibody-mediated NK cell activation to HIV-1 Env in individuals with chronic HIV-1 infection Retrovirology. 9: 171. DOI: 10.1186/1742-4690-9-S2-P171  0.462
2012 Tully D, Power K, Bedard H, Boutwell C, Charlebois P, Ryan E, Lennon N, Altfeld M, Henn, Allen T. A deeper view of transmitted/founder viruses using 454 whole genome deep sequencing Retrovirology. 9: 1-1. DOI: 10.1186/1742-4690-9-S2-O58  0.419
2011 Mothe B, Llano A, Ibarrondo J, Daniels M, Miranda C, Zamarreño J, Bach V, Zuniga R, Pérez-Álvarez S, Berger CT, Puertas MC, Martinez-Picado J, Rolland M, Farfan M, Szinger JJ, ... ... Allen TM, et al. Definition of the viral targets of protective HIV-1-specific T cell responses. Journal of Translational Medicine. 9: 208. PMID 22152067 DOI: 10.1186/1479-5876-9-208  0.499
2011 Neumann-Haefelin C, Oniangue-Ndza C, Kuntzen T, Schmidt J, Nitschke K, Sidney J, Caillet-Saguy C, Binder M, Kersting N, Kemper MW, Power KA, Ingber S, Reyor LL, Hills-Evans K, Kim AY, ... ... Allen TM, et al. Human leukocyte antigen B27 selects for rare escape mutations that significantly impair hepatitis C virus replication and require compensatory mutations. Hepatology (Baltimore, Md.). 54: 1157-66. PMID 22006856 DOI: 10.1002/Hep.24541  0.438
2011 Buranapraditkun S, Hempel U, Pitakpolrat P, Allgaier RL, Thantivorasit P, Lorenzen SI, Sirivichayakul S, Hildebrand WH, Altfeld M, Brander C, Walker BD, Phanuphak P, Hansasuta P, Rowland-Jones SL, Allen TM, et al. A novel immunodominant CD8+ T cell response restricted by a common HLA-C allele targets a conserved region of Gag HIV-1 clade CRF01_AE infected Thais. Plos One. 6: e23603. PMID 21887282 DOI: 10.1371/Journal.Pone.0023603  0.512
2011 Oniangue-Ndza C, Kuntzen T, Kemper M, Berical A, Wang YE, Neumann-Haefelin C, Foote PK, Hills-Evans K, Reyor LL, Kane K, Gladden AD, Bloom AK, Power KA, Thimme R, Lauer GM, ... ... Allen TM, et al. Compensatory mutations restore the replication defects caused by cytotoxic T lymphocyte escape mutations in hepatitis C virus polymerase. Journal of Virology. 85: 11883-90. PMID 21880756 DOI: 10.1128/Jvi.00779-11  0.413
2011 Alter G, Heckerman D, Schneidewind A, Fadda L, Kadie CM, Carlson JM, Oniangue-Ndza C, Martin M, Li B, Khakoo SI, Carrington M, Allen TM, Altfeld M. HIV-1 adaptation to NK-cell-mediated immune pressure. Nature. 476: 96-100. PMID 21814282 DOI: 10.1038/Nature10237  0.495
2011 Peng LF, Schaefer EA, Maloof N, Skaff A, Berical A, Belon CA, Heck JA, Lin W, Frick DN, Allen TM, Miziorko HM, Schreiber SL, Chung RT. Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl-coenzyme A synthase. The Journal of Infectious Diseases. 204: 609-16. PMID 21791663 DOI: 10.1093/Infdis/Jir303  0.314
2011 Dahirel V, Shekhar K, Pereyra F, Miura T, Artyomov M, Talsania S, Allen TM, Altfeld M, Carrington M, Irvine DJ, Walker BD, Chakraborty AK. Coordinate linkage of HIV evolution reveals regions of immunological vulnerability. Proceedings of the National Academy of Sciences of the United States of America. 108: 11530-5. PMID 21690407 DOI: 10.1073/Pnas.1105315108  0.416
2011 Wheeler LA, Trifonova R, Vrbanac V, Basar E, McKernan S, Xu Z, Seung E, Deruaz M, Dudek T, Einarsson JI, Yang L, Allen TM, Luster AD, Tager AM, Dykxhoorn DM, et al. Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras. The Journal of Clinical Investigation. 121: 2401-12. PMID 21576818 DOI: 10.1172/Jci45876  0.449
2011 Rolland M, Frahm N, Nickle DC, Jojic N, Deng W, Allen TM, Brander C, Heckerman DE, Mullins JI. Increased breadth and depth of cytotoxic T lymphocytes responses against HIV-1-B Nef by inclusion of epitope variant sequences. Plos One. 6: e17969. PMID 21464919 DOI: 10.1371/Journal.Pone.0017969  0.488
2011 Brumme ZL, Li C, Miura T, Sela J, Rosato PC, Brumme CJ, Markle TJ, Martin E, Block BL, Trocha A, Kadie CM, Allen TM, Pereyra F, Heckerman D, Walker BD, et al. Reduced replication capacity of NL4-3 recombinant viruses encoding reverse transcriptase-integrase sequences from HIV-1 elite controllers. Journal of Acquired Immune Deficiency Syndromes (1999). 56: 100-8. PMID 21124229 DOI: 10.1097/Qai.0B013E3181Fe9450  0.47
2011 Yu Q, Ryan EM, Allen TM, Birren BW, Henn MR, Lennon NJ. PriSM: a primer selection and matching tool for amplification and sequencing of viral genomes. Bioinformatics (Oxford, England). 27: 266-7. PMID 21068001 DOI: 10.1093/Bioinformatics/Btq624  0.367
2011 Kim AY, Kuntzen T, Timm J, Nolan BE, Baca MA, Reyor LL, Berical AC, Feller AJ, Johnson KL, Schulze zur Wiesch J, Robbins GK, Chung RT, Walker BD, Carrington M, Allen TM, et al. Spontaneous control of HCV is associated with expression of HLA-B 57 and preservation of targeted epitopes. Gastroenterology. 140: 686-696.e1. PMID 20875418 DOI: 10.1053/J.Gastro.2010.09.042  0.436
2011 Schmidt J, Wunsch K, Kuntzen T, Oniangue-Ndza C, Allen T, Thimme R, Neumann-Haefelin C. Protection from persistent hepatitis C virus infection by HLA class I: The need for multiple escape mutations in immunodominant T cell epitopes is a common feature Zeitschrift Fur Gastroenterologie. 49. DOI: 10.1055/S-0030-1269696  0.452
2011 Kuntzen T, Neumann-Haefelin C, Lennon N, Talal A, Carlson J, Brumme C, Timm J, Schmidt J, Wunsch K, Berical A, Berlin A, Adams S, Young S, Reyor L, Kleyman M, ... ... Allen T, et al. 3 POPULATIONAL ANALYSIS REVEALS A LINK BETWEEN COMPLEX VIRAL ESCAPE FROM CD8+ T-CELL RESPONSES AND PROTECTION IN HCV INFECTION Journal of Hepatology. 54: S2. DOI: 10.1016/S0168-8278(11)60005-6  0.436
2010 McMahan RH, Golden-Mason L, Nishimura MI, McMahon BJ, Kemper M, Allen TM, Gretch DR, Rosen HR. Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity. The Journal of Clinical Investigation. 120: 4546-57. PMID 21084749 DOI: 10.1172/Jci43127  0.388
2010 Pereyra F, Jia X, McLaren PJ, Telenti A, de Bakker PI, Walker BD, Ripke S, Brumme CJ, Pulit SL, Carrington M, Kadie CM, Carlson JM, Heckerman D, Graham RR, ... ... Allen TM, et al. The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Science (New York, N.Y.). 330: 1551-7. PMID 21051598 DOI: 10.1126/Science.1195271  0.431
2010 Boutwell CL, Rolland MM, Herbeck JT, Mullins JI, Allen TM. Viral evolution and escape during acute HIV-1 infection. The Journal of Infectious Diseases. 202: S309-14. PMID 20846038 DOI: 10.1086/655653  0.488
2010 Brockman MA, Brumme ZL, Brumme CJ, Miura T, Sela J, Rosato PC, Kadie CM, Carlson JM, Markle TJ, Streeck H, Kelleher AD, Markowitz M, Jessen H, Rosenberg E, Altfeld M, ... ... Allen TM, et al. Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infection. Journal of Virology. 84: 11937-49. PMID 20810731 DOI: 10.1128/Jvi.01086-10  0.475
2010 Kosmrlj A, Read EL, Qi Y, Allen TM, Altfeld M, Deeks SG, Pereyra F, Carrington M, Walker BD, Chakraborty AK. Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection. Nature. 465: 350-4. PMID 20445539 DOI: 10.1038/Nature08997  0.532
2010 Neumann-Haefelin C, Timm J, Schmidt J, Kersting N, Fitzmaurice K, Oniangue-Ndza C, Kemper MN, Humphreys I, McKiernan S, Kelleher D, Lohmann V, Bowness P, Huzly D, Rosen HR, Kim AY, ... ... Allen TM, et al. Protective effect of human leukocyte antigen B27 in hepatitis C virus infection requires the presence of a genotype-specific immunodominant CD8+ T-cell epitope. Hepatology (Baltimore, Md.). 51: 54-62. PMID 20034048 DOI: 10.1002/Hep.23275  0.472
2010 Kasprowicz V, Kang YH, Lucas M, Schulze zur Wiesch J, Kuntzen T, Fleming V, Nolan BE, Longworth S, Berical A, Bengsch B, Thimme R, Lewis-Ximenez L, Allen TM, Kim AY, Klenerman P, et al. Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution. Journal of Virology. 84: 1656-63. PMID 19906915 DOI: 10.1128/Jvi.01499-09  0.451
2010 Henn MR, Lennon NJ, Newman R, Charlebois P, Boutwell C, OhAinle M, Berlin A, Ryan E, Malboeuf C, Macalalad A, Casali M, Erlich R, Bigelow H, Green L, Gnerre S, ... ... Allen TM, et al. Sensitive population profiling and genome assembly of HIV and Flaviviruses using ultra-deep sequencing technologies Genome Biology. 11: P18. DOI: 10.1186/Gb-2010-11-S1-P18  0.41
2010 Neumann-Haefelin C, Oniangue-Ndza C, Kuntzen T, Kim A, Lauer G, Thimme R, Allen T. Seltene Escapemutationen in einem HLA-B27 restringierten CD8+ T-Zell-Epitop erfordern kompensatorische Mutationen Zeitschrift Fur Gastroenterologie. 48. DOI: 10.1055/S-0030-1254677  0.378
2010 Neumann-Haefelin C, Oniangue-Ndza C, Kuntzen T, Kemper M, Power K, Ingber S, Reyor L, Hills-Evans K, Kim A, Lauer G, Thimme R, Allen T. Tailoring of hepatitis C virus escape from an HLA-B27 restricted CD8+ T cell epitope Zeitschrift Fur Gastroenterologie. 48. DOI: 10.1055/S-0029-1246526  0.448
2009 Schneidewind A, Tang Y, Brockman MA, Ryland EG, Dunkley-Thompson J, Steel-Duncan JC, St John MA, Conrad JA, Kalams SA, Noel F, Allen TM, Christie CD, Feeney ME. Maternal transmission of human immunodeficiency virus escape mutations subverts HLA-B57 immunodominance but facilitates viral control in the haploidentical infant. Journal of Virology. 83: 8616-27. PMID 19515764 DOI: 10.1128/Jvi.00730-09  0.395
2009 Matthews PC, Leslie AJ, Katzourakis A, Crawford H, Payne R, Prendergast A, Power K, Kelleher AD, Klenerman P, Carlson J, Heckerman D, Ndung'u T, Walker BD, Allen TM, Pybus OG, et al. HLA footprints on human immunodeficiency virus type 1 are associated with interclade polymorphisms and intraclade phylogenetic clustering. Journal of Virology. 83: 4605-15. PMID 19244334 DOI: 10.1128/Jvi.02017-08  0.466
2009 Kawashima Y, Pfafferott K, Frater J, Matthews P, Payne R, Addo M, Gatanaga H, Fujiwara M, Hachiya A, Koizumi H, Kuse N, Oka S, Duda A, Prendergast A, Crawford H, ... ... Allen T, et al. Adaptation of HIV-1 to human leukocyte antigen class I. Nature. 458: 641-5. PMID 19242411 DOI: 10.1038/Nature07746  0.522
2009 Kim AY, Timm J, Nolan BE, Reyor LL, Kane K, Berical AC, Zachary KC, Lauer GM, Kuntzen T, Allen TM. Temporal dynamics of a predominant protease inhibitor-resistance mutation in a treatment-naive, hepatitis C virus-infected individual. The Journal of Infectious Diseases. 199: 737-41. PMID 19199553 DOI: 10.1086/596657  0.357
2009 Chen H, Piechocka-Trocha A, Miura T, Brockman MA, Julg BD, Baker BM, Rothchild AC, Block BL, Schneidewind A, Koibuchi T, Pereyra F, Allen TM, Walker BD. Differential neutralization of human immunodeficiency virus (HIV) replication in autologous CD4 T cells by HIV-specific cytotoxic T lymphocytes. Journal of Virology. 83: 3138-49. PMID 19158248 DOI: 10.1128/Jvi.02073-08  0.541
2009 Miura T, Brockman MA, Schneidewind A, Lobritz M, Pereyra F, Rathod A, Block BL, Brumme ZL, Brumme CJ, Baker B, Rothchild AC, Li B, Trocha A, Cutrell E, Frahm N, ... ... Allen TM, et al. HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte [corrected] recognition. Journal of Virology. 83: 2743-55. PMID 19116253 DOI: 10.1128/Jvi.02265-08  0.51
2009 Streeck H, Jessen H, Kuecherer C, Li B, Jessen AB, Dupke S, Baumgarten A, Stahmer I, van Lunzen J, Altfeld M, Walker BD, Allen TM. Epidemiologically linked transmission of HIV-1 illustrates the impact of host genetics on virological outcome. Aids (London, England). 23: 259-62. PMID 19098497 DOI: 10.1097/Qad.0B013E328315A78B  0.43
2009 Dalmau J, Puertas MC, Azuara M, Mariño A, Frahm N, Mothe B, Izquierdo-Useros N, Buzón MJ, Paredes R, Matas L, Allen TM, Brander C, Rodrigo C, Clotet B, Martinez-Picado J. Contribution of immunological and virological factors to extremely severe primary HIV type 1 infection. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 48: 229-38. PMID 19093810 DOI: 10.1086/595704  0.514
2009 Schneidewind A, Brumme ZL, Brumme CJ, Power KA, Reyor LL, O'Sullivan K, Gladden A, Hempel U, Kuntzen T, Wang YE, Oniangue-Ndza C, Jessen H, Markowitz M, Rosenberg ES, Sékaly RP, ... ... Allen TM, et al. Transmission and long-term stability of compensated CD8 escape mutations. Journal of Virology. 83: 3993-7. PMID 19091871 DOI: 10.1128/Jvi.01108-08  0.359
2009 Wang YE, Li B, Carlson JM, Streeck H, Gladden AD, Goodman R, Schneidewind A, Power KA, Toth I, Frahm N, Alter G, Brander C, Carrington M, Walker BD, Altfeld M, ... ... Allen TM, et al. Protective HLA class I alleles that restrict acute-phase CD8+ T-cell responses are associated with viral escape mutations located in highly conserved regions of human immunodeficiency virus type 1. Journal of Virology. 83: 1845-55. PMID 19036810 DOI: 10.1128/Jvi.01061-08  0.493
2009 Miura T, Brockman MA, Brumme ZL, Brumme CJ, Pereyra F, Trocha A, Block BL, Schneidewind A, Allen TM, Heckerman D, Walker BD. HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1. Journal of Virology. 83: 140-9. PMID 18971283 DOI: 10.1128/Jvi.01471-08  0.472
2009 Henn MR, Boutwell C, Lennon N, Power K, Malboeuf C, Charlebois P, Gladden A, Levin J, Casali M, Philips L, Berlin A, Berical A, Erlich R, Anderson S, Streeck H, ... ... Allen TM, et al. P09-20 LB. Ultra-deep sequencing of full-length HIV-1 genomes identifies rapid viral evolution during acute infection Retrovirology. 6. DOI: 10.1186/1742-4690-6-S3-P400  0.35
2009 Boutwell C, Schneidewind A, Brumme Z, Brockman M, Streeck H, Brumme C, Dudek T, Kane K, Kemper M, Walker B, Altfeld M, Allen T. P09-19 LB. CTL escape mutations in gag epitopes restricted by protective HLA class I alleles cause substantial reductions in viral replication capacity Retrovirology. 6: 399. DOI: 10.1186/1742-4690-6-S3-P399  0.367
2009 Sirivichayakul S, Felber B, Kulkarni V, Pavlakis G, Buranapraditkun S, Thantiworasit P, Pitakpolrat P, Allen T, Leitner T, Korber B, Ruxrungtham K. P19-01. Pre-clinical immunogenicity of mosaic Asian AE/B HIV-1 DNA vaccine in mice Retrovirology. 6: 321. DOI: 10.1186/1742-4690-6-S3-P321  0.408
2009 Hempel U, Buranapraditkun S, Chatkulkawin P, Pitakpolrat P, Phillips LC, Allgaier RL, Lorenzen S, Hildebrand WH, Leitner T, Matthews P, Goulder P, Walker BD, Ruxrungtham K, Allen TM. P16-07. HLA-B1302 is associated with viral control in clade CRF01_AE HIV-1 infection in Thailand Retrovirology. 6. DOI: 10.1186/1742-4690-6-S3-P236  0.526
2009 Oniangue-Ndza C, Schneidewind A, Brockman MA, Brumme ZL, Boutwell CL, Wang YE, Brumme CJ, Power KA, Gladden AD, Kemper M, Le Gall S, Streeck H, Alter G, Altfeld M, Heckerman D, ... ... Allen TM, et al. P09-10. Impact of CTL escape mutations in HIV-1 Nef on viral replication Retrovirology. 6: P123. DOI: 10.1186/1742-4690-6-S3-P123  0.498
2009 Miura T, Brockman MA, Schneidewind A, Lobritz M, Pereyra F, Rathod A, Block BL, Brumme ZL, Brumme CJ, Baker B, Rothchild AC, Li B, Trocha A, Cutrell E, Frahm N, ... ... Allen TM, et al. HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte recognition (Journal of Virology (2009) 83, 6, (2743-2755)) Journal of Virology. 83: 5961. DOI: 10.1128/Jvi.00579-09  0.432
2008 Mullins JI, Rolland M, Allen TM. Viral evolution and escape during primary human immunodeficiency virus-1 infection: implications for vaccine design. Current Opinion in Hiv and Aids. 3: 60-6. PMID 19372945 DOI: 10.1097/Coh.0B013E3282F233D9  0.493
2008 Kuntzen T, Timm J, Berical A, Lennon N, Berlin AM, Young SK, Lee B, Heckerman D, Carlson J, Reyor LL, Kleyman M, McMahon CM, Birch C, Schulze Zur Wiesch J, Ledlie T, ... ... Allen TM, et al. Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patients. Hepatology (Baltimore, Md.). 48: 1769-78. PMID 19026009 DOI: 10.1002/Hep.22549  0.361
2008 Wölfl M, Rutebemberwa A, Mosbruger T, Mao Q, Li HM, Netski D, Ray SC, Pardoll D, Sidney J, Sette A, Allen T, Kuntzen T, Kavanagh DG, Kuball J, Greenberg PD, et al. Hepatitis C virus immune escape via exploitation of a hole in the T cell repertoire. Journal of Immunology (Baltimore, Md. : 1950). 181: 6435-46. PMID 18941234 DOI: 10.4049/Jimmunol.181.9.6435  0.483
2008 Yerly D, Heckerman D, Allen T, Suscovich TJ, Jojic N, Kadie C, Pichler WJ, Cerny A, Brander C. Design, expression, and processing of epitomized hepatitis C virus-encoded CTL epitopes. Journal of Immunology (Baltimore, Md. : 1950). 181: 6361-70. PMID 18941227 DOI: 10.4049/Jimmunol.181.9.6361  0.405
2008 Streeck H, Li B, Poon AF, Schneidewind A, Gladden AD, Power KA, Daskalakis D, Bazner S, Zuniga R, Brander C, Rosenberg ES, Frost SD, Altfeld M, Allen TM. Immune-driven recombination and loss of control after HIV superinfection. The Journal of Experimental Medicine. 205: 1789-96. PMID 18625749 DOI: 10.1084/Jem.20080281  0.52
2008 Brumme ZL, Brumme CJ, Carlson J, Streeck H, John M, Eichbaum Q, Block BL, Baker B, Kadie C, Markowitz M, Jessen H, Kelleher AD, Rosenberg E, Kaldor J, Yuki Y, ... ... Allen TM, et al. Marked epitope- and allele-specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute/early HIV-1 infection. Journal of Virology. 82: 9216-27. PMID 18614631 DOI: 10.1128/Jvi.01041-08  0.507
2008 Miura T, Brockman MA, Brumme CJ, Brumme ZL, Carlson JM, Pereyra F, Trocha A, Addo MM, Block BL, Rothchild AC, Baker BM, Flynn T, Schneidewind A, Li B, Wang YE, ... ... Allen TM, et al. Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changes. Journal of Virology. 82: 8422-30. PMID 18562530 DOI: 10.1128/Jvi.00535-08  0.464
2008 Kuntzen T, Berical A, Ndjomou J, Bennett P, Schneidewind A, Lennon N, Birren BW, Kuiken C, Henn MR, Simmonds P, Allen TM. A set of reference sequences for the hepatitis C genotypes 4d, 4f, and 4k covering the full open reading frame. Journal of Medical Virology. 80: 1370-8. PMID 18551618 DOI: 10.1002/Jmv.21240  0.343
2008 Streeck H, Brumme ZL, Anastario M, Cohen KW, Jolin JS, Meier A, Brumme CJ, Rosenberg ES, Alter G, Allen TM, Walker BD, Altfeld M. Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells. Plos Medicine. 5: e100. PMID 18462013 DOI: 10.1371/Journal.Pmed.0050100  0.562
2008 Allen TM, Altfeld M. Crippling HIV one mutation at a time. The Journal of Experimental Medicine. 205: 1003-7. PMID 18458116 DOI: 10.1084/Jem.20080569  0.492
2008 Neumann-Haefelin C, Timm J, Spangenberg HC, Wischniowski N, Nazarova N, Kersting N, Roggendorf M, Allen TM, Blum HE, Thimme R. Virological and immunological determinants of intrahepatic virus-specific CD8+ T-cell failure in chronic hepatitis C virus infection. Hepatology (Baltimore, Md.). 47: 1824-36. PMID 18454507 DOI: 10.1002/Hep.22242  0.486
2008 Schneidewind A, Brockman MA, Sidney J, Wang YE, Chen H, Suscovich TJ, Li B, Adam RI, Allgaier RL, Mothé BR, Kuntzen T, Oniangue-Ndza C, Trocha A, Yu XG, Brander C, ... ... Allen TM, et al. Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid. Journal of Virology. 82: 5594-605. PMID 18385228 DOI: 10.1128/Jvi.02356-07  0.417
2008 Frahm N, Nickle DC, Linde CH, Cohen DE, Zuñiga R, Lucchetti A, Roach T, Walker BD, Allen TM, Korber BT, Mullins JI, Brander C. Increased detection of HIV-specific T cell responses by combination of central sequences with comparable immunogenicity. Aids (London, England). 22: 447-56. PMID 18301057 DOI: 10.1097/Qad.0B013E3282F42412  0.446
2008 Yerly D, Heckerman D, Allen TM, Chisholm JV, Faircloth K, Linde CH, Frahm N, Timm J, Pichler WJ, Cerny A, Brander C. Increased cytotoxic T-lymphocyte epitope variant cross-recognition and functional avidity are associated with hepatitis C virus clearance. Journal of Virology. 82: 3147-53. PMID 18184704 DOI: 10.1128/Jvi.02252-07  0.431
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2008 Mullins JI, Rolland M, Allen TM. Viral evolution and escape during primary human immunodeficiency virus-1 infection: Implications for vaccine design Current Opinion in Hiv and Aids. 3: 60-66. DOI: 10.1097/COH.0b013e3282f233d9  0.408
2008 Wiesch JCSz, Kim AY, Kasprowicz V, Timm J, Kuntzen T, Nolan BE, Longworth S, Berical A, Lohse AW, Chung RT, Walker B, Allen T, Lauer GM. CD4 functionality determines outcome in acute HCV re-infection Zeitschrift Fur Gastroenterologie. 46. DOI: 10.1055/S-2008-1037622  0.35
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2007 Lichterfeld M, Kavanagh DG, Williams KL, Moza B, Mui SK, Miura T, Sivamurthy R, Allgaier R, Pereyra F, Trocha A, Feeney M, Gandhi RT, Rosenberg ES, Altfeld M, Allen TM, et al. A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells. The Journal of Experimental Medicine. 204: 2813-24. PMID 18025130 DOI: 10.1084/Jem.20061865  0.495
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2007 Frahm N, Kaufmann DE, Yusim K, Muldoon M, Kesmir C, Linde CH, Fischer W, Allen TM, Li B, McMahon BH, Faircloth KL, Hewitt HS, Mackey EW, Miura T, Khatri A, et al. Increased sequence diversity coverage improves detection of HIV-specific T cell responses. Journal of Immunology (Baltimore, Md. : 1950). 179: 6638-50. PMID 17982054 DOI: 10.4049/Jimmunol.179.10.6638  0.469
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2007 Streeck H, Schweighardt B, Jessen H, Allgaier RL, Wrin T, Stawiski EW, Jessen AB, Allen TM, Walker BD, Altfeld M. Loss of HIV-1-specific T-cell responses associated with very rapid HIV-1 disease progression. Aids (London, England). 21: 889-91. PMID 17415054 DOI: 10.1097/Qad.0B013E3280F77439  0.42
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2004 Lauer GM, Barnes E, Lucas M, Timm J, Ouchi K, Kim AY, Day CL, Robbins GK, Casson DR, Reiser M, Dusheiko G, Allen TM, Chung RT, Walker BD, Klenerman P. High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection Gastroenterology. 127: 924-936. PMID 15362047 DOI: 10.1053/J.Gastro.2004.06.015  0.479
2004 Lichterfeld M, Yu XG, Cohen D, Addo MM, Malenfant J, Perkins B, Pae E, Johnston MN, Strick D, Allen TM, Rosenberg ES, Korber B, Walker BD, Altfeld M. HIV-1 Nef is preferentially recognized by CD8 T cells in primary HIV-1 infection despite a relatively high degree of genetic diversity. Aids (London, England). 18: 1383-92. PMID 15199314 DOI: 10.1097/01.Aids.0000131329.51633.A3  0.5
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2004 Draenert R, Verrill CL, Tang Y, Allen TM, Wurcel AG, Boczanowski M, Lechner A, Kim AY, Suscovich T, Brown NV, Addo MM, Walker BD. Persistent Recognition of Autologous Virus by High-Avidity CD8 T Cells in Chronic, Progressive Human Immunodeficiency Virus Type 1 Infection Journal of Virology. 78: 630-641. PMID 14694094 DOI: 10.1128/Jvi.78.2.630-641.2004  0.521
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2003 Meyer-Olson D, Brady KW, Blackard JT, Allen TM, Islam S, Shoukry NH, Hartman K, Walker CM, Kalams SA. Analysis of the TCR beta variable gene repertoire in chimpanzees: identification of functional homologs to human pseudogenes. Journal of Immunology (Baltimore, Md. : 1950). 170: 4161-9. PMID 12682248 DOI: 10.4049/Jimmunol.170.8.4161  0.399
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2003 Timm J, Lauer GM, Lewis-Ximenez LL, Ouchi K, Kim AY, Walker BD, Allen TM. 400 Longitudinal full genome sequencing to assess the extent of CD8+ CTL escape in HCV Hepatology. 38: 352-353. DOI: 10.1016/S0270-9139(03)80443-3  0.325
2002 Altfeld M, Allen TM, Yu XG, Johnston MN, Agrawal D, Korber BT, Montefiori DC, O'Connor DH, Davis BT, Lee PK, Maier EL, Harlow J, Goulder PJ, Brander C, Rosenberg ES, et al. HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus. Nature. 420: 434-9. PMID 12459786 DOI: 10.1038/Nature01200  0.547
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2002 Allen TM, Kelleher AD, Zaunders J, Walker BD. STI and beyond: the prospects of boosting anti-HIV immune responses. Trends in Immunology. 23: 456-460. PMID 12200068 DOI: 10.1016/S1471-4906(02)02297-4  0.393
2002 Earl PL, Wyatt LS, Montefiori DC, Bilska M, Woodward R, Markham PD, Malley JD, Vogel TU, Allen TM, Watkins DI, Miller N, Moss B. Comparison of vaccine strategies using recombinant env-gag-pol MVA with or without an oligomeric env protein boost in the SHIV rhesus macaque model Virology. 294: 270-281. PMID 12009868 DOI: 10.1006/Viro.2001.1345  0.571
2002 O'Connor DH, Allen TM, Vogel TU, Jing P, DeSouza IP, Dodds E, Dunphy EJ, Melsaether C, Mothé B, Yamamoto H, Horton H, Wilson N, Hughes AL, Watkins DI. Acute phase cytotoxic T lymphocyte escape is a hallmark of simian immunodeficiency virus infection. Nature Medicine. 8: 493-9. PMID 11984594 DOI: 10.1038/Nm0502-493  0.633
2002 Allen TM, Mortara L, Mothé BR, Liebl M, Jing P, Calore B, Piekarczyk M, Ruddersdorf R, O'Connor DH, Wang X, Wang C, Allison DB, Altman JD, Sette A, Desrosiers RC, et al. Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 replication. Journal of Virology. 76: 4108-12. PMID 11907251 DOI: 10.1128/Jvi.76.8.4108-4112.2002  0.591
2002 Mothé BR, Horton H, Carter DK, Allen TM, Liebl ME, Skinner P, Vogel TU, Fuenger S, Vielhuber K, Rehrauer W, Wilson N, Franchini G, Altman JD, Haase A, Picker LJ, et al. Dominance of CD8 responses specific for epitopes bound by a single major histocompatibility complex class I molecule during the acute phase of viral infection. Journal of Virology. 76: 875-84. PMID 11752176 DOI: 10.1128/Jvi.76.2.875-884.2002  0.618
2001 Allen TM, Watkins DI. New insights into evaluating effective T-cell responses to HIV. Aids. 15. PMID 11816159 DOI: 10.1097/00002030-200100005-00015  0.634
2001 O'Connor D, Friedrich T, Hughes A, Allen TM, Watkins D. Understanding cytotoxic T‐lymphocyte escape during simian immunodeficiency virus infection Immunological Reviews. 183: 115-126. PMID 11782252 DOI: 10.1034/J.1600-065X.2001.1830110.X  0.657
2001 Belyakov IM, Hel Z, Kelsall B, Kuznetsov VA, Ahlers JD, Nacsa J, Watkins DI, Allen TM, Sette A, Altman J, Woodward R, Markham PD, Clements JD, Franchini G, Strober W, et al. Mucosal AIDS vaccine reduces disease and viral load in gut reservoir and blood after mucosal infection of macaques. Nature Medicine. 7: 1320-6. PMID 11726972 DOI: 10.1038/Nm1201-1320  0.634
2001 Hel Z, Nacsa J, Kelsall B, Tsai WP, Letvin N, Parks RW, Tryniszewska E, Picker L, Lewis MG, Edghill-Smith Y, Moniuszko M, Pal R, Stevceva L, Altman JD, Allen TM, et al. Impairment of Gag-specific CD8(+) T-cell function in mucosal and systemic compartments of simian immunodeficiency virus mac251- and simian-human immunodeficiency virus KU2-infected macaques. Journal of Virology. 75: 11483-95. PMID 11689630 DOI: 10.1128/Jvi.75.23.11483-11495.2001  0.643
2001 O'Connor D, Allen T, Watkins DI. Vaccination with CTL epitopes that escape: an alternative approach to HIV vaccine development? Immunology Letters. 79: 77-84. PMID 11595292 DOI: 10.1016/S0165-2478(01)00268-1  0.609
2001 Urvater JA, Hickman H, Dzuris JL, Prilliman K, Allen TM, Schwartz KJ, Lorentzen D, Shufflebotham C, Collins EJ, Neiffer DL, Raphael B, Hildebrand W, Sette A, Watkins DI. Gorillas with spondyloarthropathies express an MHC class I molecule with only limited sequence similarity to HLA-B27 that binds peptides with arginine at P2 Journal of Immunology. 166: 3334-3344. PMID 11207289 DOI: 10.4049/Jimmunol.166.5.3334  0.496
2001 Vogel TU, Allen TM, Altman JD, Watkins DI. Functional impairment of simian immunodeficiency virus-specific CD8+ T cells during the chronic phase of infection. Journal of Virology. 75: 2458-61. PMID 11160749 DOI: 10.1128/Jvi.75.5.2458-2461.2001  0.625
2001 Allen TM, Mothé BR, Sidney J, Jing P, Dzuris JL, Liebl ME, Vogel TU, O'Connor DH, Wang X, Wussow MC, Thomson JA, Altman JD, Watkins DI, Sette A. CD8(+) lymphocytes from simian immunodeficiency virus-infected rhesus macaques recognize 14 different epitopes bound by the major histocompatibility complex class I molecule mamu-A*01: implications for vaccine design and testing. Journal of Virology. 75: 738-49. PMID 11134287 DOI: 10.1128/Jvi.75.2.738-749.2001  0.614
2000 Allen TM, O'Connor DH, Jing P, Dzuris JL, Mothé BR, Vogel TU, Dunphy E, Liebl ME, Emerson C, Wilson N, Kunstman KJ, Wang X, Allison DB, Hughes AL, Desrosiers RC, et al. Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia. Nature. 407: 386-90. PMID 11014195 DOI: 10.1038/35030124  0.679
2000 Cromwell MA, Veazey RS, Altman JD, Mansfield KG, Glickman R, Allen TM, Watkins DI, Lackner AA, Johnson RP. Induction of mucosal homing virus-specific CD8(+) T lymphocytes by attenuated simian immunodeficiency virus. Journal of Virology. 74: 8762-6. PMID 10954580 DOI: 10.1128/Jvi.74.18.8762-8766.2000  0.629
2000 Evans DT, Jing P, Allen TM, O'Connor DH, Horton H, Venham JE, Piekarczyk M, Dzuris J, Dykhuzen M, Mitchen J, Rudersdorf RA, Pauza CD, Sette A, Bontrop RE, DeMars R, et al. Definition of five new simian immunodeficiency virus cytotoxic T-lymphocyte epitopes and their restricting major histocompatibility complex class I molecules: evidence for an influence on disease progression. Journal of Virology. 74: 7400-10. PMID 10906193 DOI: 10.1128/Jvi.74.16.7400-7410.2000  0.577
2000 Urvater JA, McAdam SN, Loehrke JH, Allen TM, Moran JL, Rowell TJ, Rojo S, Castro JALd, Taurog JD, Watkins DI. A high incidence of Shigella -induced arthritis in a primate species: major histocompatibility complex class I molecules associated with resistance and susceptiblity, and their relationship to HLA-B27 Immunogenetics. 51: 314-325. PMID 10803844 DOI: 10.1007/S002510050625  0.506
2000 Allen TM, Vogel TU, Fuller DH, Mothé BR, Steffen S, Boyson JE, Shipley T, Fuller J, Hanke T, Sette A, Altman JD, Moss B, McMichael AJ, Watkins DI. Induction of AIDS virus-specific CTL activity in fresh, unstimulated peripheral blood lymphocytes from rhesus macaques vaccinated with a DNA prime/modified vaccinia virus Ankara boost regimen. Journal of Immunology (Baltimore, Md. : 1950). 164: 4968-78. PMID 10779808 DOI: 10.4049/Jimmunol.164.9.4968  0.602
1999 Evans DT, O'Connor DH, Jing P, Dzuris JL, Sidney J, da Silva J, Allen TM, Horton H, Venham JE, Rudersdorf RA, Vogel T, Pauza CD, Bontrop RE, DeMars R, Sette A, et al. Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef. Nature Medicine. 5: 1270-6. PMID 10545993 DOI: 10.1038/15224  0.603
1999 Furchner M, Erickson AL, Allen T, Watkins DI, Sette A, Johnson PR, Walker CM. The Simian Immunodeficiency Virus Envelope Glycoprotein Contains Two Epitopes Presented by the Mamu-A*01 Class I Molecule Journal of Virology. 73: 8035-8039. PMID 10482552 DOI: 10.1128/Jvi.73.10.8035-8039.1999  0.625
1999 Hanke T, Samuel RV, Blanchard TJ, Neumann VC, Allen TM, Boyson JE, Sharpe SA, Cook N, Smith GL, Watkins DI, Cranage MP, McMichael AJ. Effective Induction of Simian Immunodeficiency Virus-Specific Cytotoxic T Lymphocytes in Macaques by Using a Multiepitope Gene and DNA Prime-Modified Vaccinia Virus Ankara Boost Vaccination Regimen Journal of Virology. 73: 7524-7532. PMID 10438842 DOI: 10.1128/Jvi.73.9.7524-7532.1999  0.595
1998 Kuroda MJ, Schmitz JE, Barouch DH, Craiu A, Allen TM, Sette A, Watkins DI, Forman MA, Letvin NL. Analysis of gag-specific cytotoxic T lymphocytes in simian immunodeficiency virus-infected rhesus monkeys by cell staining with a tetrameric major histocompatibility complex class I-peptide complex Journal of Experimental Medicine. 187: 1373-1381. PMID 9565630 DOI: 10.1084/Jem.187.9.1373  0.572
1996 Allen TM, Lanchbury JS, Hughes AL, Watkins DI. The T-cell receptor beta chain-encoding gene repertoire of a New World primate species, the cotton-top tamarin. Immunogenetics. 45: 151-160. PMID 8952965 DOI: 10.1007/S002510050183  0.5
1996 Evans DT, Piekarczyk MS, Allen TM, Boyson JE, Hinshaw VS, Watkins DI. Epitope sharing as a consequence of limited MHC class I polymorphism and sequence variation in the cotton-top tamarin Human Immunology. 47: 128. DOI: 10.1016/0198-8859(96)85395-X  0.483
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