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Jeffrey R. Brender, Ph.D. - Publications

Affiliations: 
University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Structural Enzymology, Protein Processing and Folding
Website:
http://rams.biop.lsa.umich.edu/lab-members/jeffrey-brender
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Year Citation  Score
2023 Kishimoto S, Devasahayam N, Chandramouli GVR, Murugesan R, Otowa Y, Yamashita K, Yamamoto K, Brender JR, Krishna MC. Evaluation of a deuterated triarylmethyl spin probe for in vivo R ∗-based EPR oximetric imaging with enhanced dynamic range. Magnetic Resonance in Medicine. PMID 37676121 DOI: 10.1002/mrm.29811  0.38
2023 Otowa Y, Kishimoto S, Saida Y, Yamashita K, Yamamoto K, Chandramouli GVR, Devasahayam N, Mitchell JB, Cherukuri MK, Brender J. Evofosfamide and Gemcitabine Act Synergistically in Pancreatic Cancer Xenografts by Dual Action on Tumor Vasculature and Inhibition of Homologous Recombination DNA Repair. Antioxidants & Redox Signaling. PMID 37051681 DOI: 10.1089/ars.2022.0118  0.4
2022 Brender JR, Ramamoorthy A, Gursky O, Bhunia A. Intrinsic disorder and structural biology: Searching where the light isn't. Biophysical Chemistry. 292: 106912. PMID 36335754 DOI: 10.1016/j.bpc.2022.106912  0.346
2021 AbuSalim JE, Yamamoto K, Miura N, Blackman B, Brender JR, Mushti C, Seki T, Camphausen KA, Swenson RE, Krishna MC, Kesarwala AH. Simple Esterification of [1-C]-Alpha-Ketoglutarate Enhances Membrane Permeability and Allows for Noninvasive Tracing of Glutamate and Glutamine Production. Acs Chemical Biology. PMID 34554724 DOI: 10.1021/acschembio.1c00561  0.439
2021 Miura N, Mushti C, Sail D, AbuSalim JE, Yamamoto K, Brender JR, Seki T, AbuSalim DI, Matsumoto S, Camphausen KA, Krishna MC, Swenson RE, Kesarwala AH. Synthesis of [1- C-5- C]-alpha-ketoglutarate enables noninvasive detection of 2-hydroxyglutarate. Nmr in Biomedicine. e4588. PMID 34263489 DOI: 10.1002/nbm.4588  0.395
2021 Yamamoto K, Opina A, Sail D, Blackman B, Saito K, Brender JR, Malinowski RM, Seki T, Oshima N, Crooks DR, Kishimoto S, Saida Y, Otowa Y, Choyke PL, Ardenkjær-Larsen JH, et al. Real-Time insight into in vivo redox status utilizing hyperpolarized [1-C] N-acetyl cysteine. Scientific Reports. 11: 12155. PMID 34108512 DOI: 10.1038/s41598-021-90921-0  0.431
2021 Saida Y, Brender JR, Yamamoto K, Mitchell JB, Krishna MC, Kishimoto S. Multimodal molecular imaging detects early responses to immune checkpoint blockade. Cancer Research. PMID 33837042 DOI: 10.1158/0008-5472.CAN-20-3182  0.39
2020 Kishimoto S, Brender J, Chandramouli GVR, Saida Y, Yamamoto K, Mitchell J, Krishna MC. Hypoxia activated prodrug evofosfamide treatment in pancreatic ductal adenocarcinoma xenografts alters the tumor redox status to potentiate radiotherapy. Antioxidants & Redox Signaling. PMID 32787454 DOI: 10.1089/Ars.2020.8131  0.451
2020 Ratha BN, Kar RK, Brender JR, Pariary R, Sahoo B, Kalita S, Bhunia A. High Resolution Structure of A Partially Folded Insulin Aggregation Intermediate. Proteins. PMID 32683793 DOI: 10.1002/Prot.25983  0.354
2020 Yamamoto K, Brender JR, Seki T, Kishimoto S, Oshima N, Choudhuri R, Adler SS, Jagoda E, Saito K, Devasahayam N, Choyke PL, Mitchell JB, Krishna MC. Molecular Imaging of the Tumor Microenvironment reveals the Relationship between Tumor Oxygenation, Glucose Uptake and Glycolysis in Pancreatic Ductal Adenocarcinoma. Cancer Research. PMID 32245793 DOI: 10.1158/0008-5472.Can-19-0928  0.458
2020 Oshima N, Ishida R, Kishimoto S, Beebe K, Brender JR, Yamamoto K, Urban D, Rai G, Johnson MS, Benavides G, Squadrito GL, Crooks D, Jackson J, Joshi A, Mott BT, et al. Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy. Cell Reports. 30: 1798-1810.e4. PMID 32049011 DOI: 10.1016/J.Celrep.2020.01.039  0.473
2019 Kishimoto S, Brender JR, Crooks DR, Matsumoto S, Seki T, Oshima N, Merkle H, Lin P, Reed G, Chen AP, Ardenkjaer-Larsen JH, Munasinghe J, Saito K, Yamamoto K, Choyke PL, et al. Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice. Elife. 8. PMID 31408004 DOI: 10.7554/Elife.46312  0.461
2019 Brender JR, Ghosh A, Kotler SA, Krishnamoorthy J, Bera S, Morris V, Sil TB, Garai K, Reif B, Bhunia A, Ramamoorthy A. Probing transient non-native states in amyloid beta fiber elongation by NMR. Chemical Communications (Cambridge, England). PMID 30917192 DOI: 10.1039/C9Cc01067J  0.797
2019 Brender JR, Kishimoto S, Merkle H, Reed G, Hurd RE, Chen AP, Ardenkjaer-Larsen JH, Munasinghe J, Saito K, Seki T, Oshima N, Yamamoto K, Choyke PL, Mitchell J, Krishna MC. Dynamic Imaging of Glucose and Lactate Metabolism by C-MRS without Hyperpolarization. Scientific Reports. 9: 3410. PMID 30833588 DOI: 10.1038/S41598-019-38981-1  0.47
2019 Kishimoto S, Brender JR, Crooks DR, Matsumoto S, Seki T, Oshima N, Merkle H, Lin P, Reed G, Chen AP, Ardenkjaer-Larsen JH, Munasinghe J, Saito K, Yamamoto K, Choyke PL, et al. Author response: Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice Elife. DOI: 10.7554/Elife.46312.016  0.448
2018 Saito K, Sail D, Yamamoto K, Matsumoto S, Blackman B, Kishimoto S, Brender J, Swenson RE, Mitchell JB, Krishna MC. Synthesis and evaluation of C-labeled 5-5-dimethyl-1-pyrroline-N-oxide aimed at in vivo detection of reactive oxygen species using hyperpolarized C-MRI. Free Radical Biology & Medicine. PMID 30471347 DOI: 10.1016/J.Freeradbiomed.2018.11.013  0.465
2018 Kar RK, Brender JR, Ghosh A, Bhunia A. Non-productive Binding Modes as a Prominent Feature of Aβ40 Fiber Elongation: Insights from Molecular Dynamics Simulation. Journal of Chemical Information and Modeling. PMID 30047732 DOI: 10.1021/Acs.Jcim.8B00169  0.394
2018 Brender JR, Krishnamoorthy J, Ghosh A, Bhunia A. Binding Moiety Mapping by Saturation Transfer Difference NMR. Methods in Molecular Biology (Clifton, N.J.). 1824: 49-65. PMID 30039401 DOI: 10.1007/978-1-4939-8630-9_4  0.697
2018 Setiawan D, Brender J, Zhang Y. Recent advances in automated protein design and its future challenges. Expert Opinion On Drug Discovery. 1-18. PMID 29695210 DOI: 10.1080/17460441.2018.1465922  0.32
2018 Sciacca MFM, Chillemi R, Sciuto S, Greco V, Messineo C, Kotler SA, Lee DK, Brender JR, Ramamoorthy A, La Rosa C, Milardi D. A blend of two resveratrol derivatives abolishes hIAPP amyloid growth and membrane damage. Biochimica Et Biophysica Acta. PMID 29555190 DOI: 10.1016/J.Bbamem.2018.03.012  0.835
2017 Brender JR, Shultis D, Khattak NA, Zhang Y. An Evolution-Based Approach to De Novo Protein Design. Methods in Molecular Biology (Clifton, N.J.). 1529: 243-264. PMID 27914055 DOI: 10.1007/978-1-4939-6637-0_12  0.35
2016 Ratha BN, Ghosh A, Brender JR, Gayen N, Ilyas H, Neeraja C, Das KP, Mandal AK, Bhunia A. Inhibition of Insulin Amyloid Fibrillation by a Novel Amphipathic Heptapeptide: Mechanistic Details Studied by Spectroscopy in Combination with Microscopy. The Journal of Biological Chemistry. PMID 27679488 DOI: 10.1074/Jbc.M116.742460  0.456
2016 Pithadia A, Brender JR, Fierke CA, Ramamoorthy A. Inhibition of IAPP Aggregation and Toxicity by Natural Products and Derivatives. Journal of Diabetes Research. 2016: 2046327. PMID 26649317 DOI: 10.1155/2016/2046327  0.822
2015 Brender JR, Zhang Y. Predicting the Effect of Mutations on Protein-Protein Binding Interactions through Structure-Based Interface Profiles. Plos Computational Biology. 11: e1004494. PMID 26506533 DOI: 10.1371/Journal.Pcbi.1004494  0.35
2015 Kotler SA, Brender JR, Vivekanandan S, Suzuki Y, Yamamoto K, Monette M, Krishnamoorthy J, Walsh P, Cauble M, Holl MM, Marsh EN, Ramamoorthy A. High-resolution NMR characterization of low abundance oligomers of amyloid-β without purification. Scientific Reports. 5: 11811. PMID 26138908 DOI: 10.1038/Srep11811  0.804
2015 Chan WK, Zhang H, Yang J, Brender JR, Hur J, Özgür A, Zhang Y. GLASS: a comprehensive database for experimentally validated GPCR-ligand associations. Bioinformatics (Oxford, England). PMID 25971743 DOI: 10.1093/Bioinformatics/Btv302  0.659
2015 Brender JR, Krishnamoorthy J, Sciacca MF, Vivekanandan S, D'Urso L, Chen J, La Rosa C, Ramamoorthy A. Probing the sources of the apparent irreproducibility of amyloid formation: drastic changes in kinetics and a switch in mechanism due to micellelike oligomer formation at critical concentrations of IAPP. The Journal of Physical Chemistry. B. 119: 2886-96. PMID 25645610 DOI: 10.1021/Jp511758W  0.815
2015 Du H, Brender JR, Zhang J, Zhang Y. Protein structure prediction provides comparable performance to crystallographic structures in docking-based virtual screening. Methods (San Diego, Calif.). 71: 77-84. PMID 25220914 DOI: 10.1016/J.Ymeth.2014.08.017  0.336
2014 Patel HR, Pithadia AS, Brender JR, Fierke CA, Ramamoorthy A. In Search of Aggregation Pathways of IAPP and Other Amyloidogenic Proteins: Finding Answers through NMR Spectroscopy. The Journal of Physical Chemistry Letters. 5: 1864-70. PMID 26273866 DOI: 10.1021/Jz5001775  0.828
2014 DeToma AS, Krishnamoorthy J, Nam Y, Lee HJ, Brender JR, Kochi A, Lee D, Onnis V, Congiu C, Manfredini S, Vertuani S, Balboni G, Ramamoorthy A, Lim MH. Synthetic Flavonoids, Aminoisoflavones: Interaction and Reactivity with Metal-Free and Metal-Associated Amyloid-β Species. Chemical Science. 5: 4851-4862. PMID 25383163 DOI: 10.1039/C4Sc01531B  0.81
2014 Kotler SA, Walsh P, Brender JR, Ramamoorthy A. Differences between amyloid-β aggregation in solution and on the membrane: insights into elucidation of the mechanistic details of Alzheimer's disease. Chemical Society Reviews. 43: 6692-700. PMID 24464312 DOI: 10.1039/C3Cs60431D  0.84
2014 Lee S, Zheng X, Krishnamoorthy J, Savelieff MG, Park HM, Brender JR, Kim JH, Derrick JS, Kochi A, Lee HJ, Kim C, Ramamoorthy A, Bowers MT, Lim MH. Rational design of a structural framework with potential use to develop chemical reagents that target and modulate multiple facets of Alzheimer's disease. Journal of the American Chemical Society. 136: 299-310. PMID 24397771 DOI: 10.1021/Ja409801P  0.769
2014 Zhao J, Hu R, Sciacca MF, Brender JR, Chen H, Ramamoorthy A, Zheng J. Non-selective ion channel activity of polymorphic human islet amyloid polypeptide (amylin) double channels. Physical Chemistry Chemical Physics : Pccp. 16: 2368-77. PMID 24352606 DOI: 10.1039/C3Cp53345J  0.747
2014 Patel HR, Pithadia AS, Brender JR, Fierke CA, Ramamoorthy A. In search of aggregation pathways of IAPP and other amyloidogenic proteins: Finding answers through NMR spectroscopy Journal of Physical Chemistry Letters. 5: 1864-1870. DOI: 10.1021/jz5001775  0.795
2013 Mitra P, Shultis D, Brender JR, Czajka J, Marsh D, Gray F, Cierpicki T, Zhang Y. An evolution-based approach to De Novo protein design and case study on Mycobacterium tuberculosis. Plos Computational Biology. 9: e1003298. PMID 24204234 DOI: 10.1371/Journal.Pcbi.1003298  0.345
2013 Hartman K, Brender JR, Monde K, Ono A, Evans ML, Popovych N, Chapman MR, Ramamoorthy A. Bacterial curli protein promotes the conversion of PAP248-286 into the amyloid SEVI: cross-seeding of dissimilar amyloid sequences. Peerj. 1: e5. PMID 23638387 DOI: 10.7717/Peerj.5  0.806
2013 Lee DK, Brender JR, Sciacca MF, Krishnamoorthy J, Yu C, Ramamoorthy A. Lipid composition-dependent membrane fragmentation and pore-forming mechanisms of membrane disruption by pexiganan (MSI-78). Biochemistry. 52: 3254-63. PMID 23590672 DOI: 10.1021/Bi400087N  0.819
2013 Brender JR, Krishnamoorthy J, Messina GM, Deb A, Vivekanandan S, La Rosa C, Penner-Hahn JE, Ramamoorthy A. Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide. Chemical Communications (Cambridge, England). 49: 3339-41. PMID 23505632 DOI: 10.1039/C3Cc40383A  0.787
2013 Brender JR, Heyl DL, Samisetti S, Kotler SA, Osborne JM, Pesaru RR, Ramamoorthy A. Membrane disordering is not sufficient for membrane permeabilization by islet amyloid polypeptide: studies of IAPP(20-29) fragments. Physical Chemistry Chemical Physics : Pccp. 15: 8908-15. PMID 23493863 DOI: 10.1039/C3Cp44696D  0.837
2013 Suzuki Y, Brender JR, Soper MT, Krishnamoorthy J, Zhou Y, Ruotolo BT, Kotov NA, Ramamoorthy A, Marsh EN. Resolution of oligomeric species during the aggregation of Aβ1-40 using (19)F NMR. Biochemistry. 52: 1903-12. PMID 23445400 DOI: 10.1021/Bi400027Y  0.786
2013 Hyung SJ, DeToma AS, Brender JR, Lee S, Vivekanandan S, Kochi A, Choi JS, Ramamoorthy A, Ruotolo BT, Lim MH. Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-β species. Proceedings of the National Academy of Sciences of the United States of America. 110: 3743-8. PMID 23426629 DOI: 10.1073/Pnas.1220326110  0.538
2013 Sciacca MF, Milardi D, Messina GM, Marletta G, Brender JR, Ramamoorthy A, La Rosa C. Cations as switches of amyloid-mediated membrane disruption mechanisms: calcium and IAPP. Biophysical Journal. 104: 173-84. PMID 23332070 DOI: 10.1016/J.Bpj.2012.11.3811  0.82
2013 Brender JR, Krishnamoorthy J, Sciacca MF, Vivekanandan S, Ramamoorthy A. Divergent Mechanisms in Amyloid Formation Controlled by Critical Points Biophysical Journal. 104: 51a. DOI: 10.1016/J.Bpj.2012.11.320  0.788
2013 Sciacca MF, Milardi D, Messina GM, Marletta G, Brender JR, Ramamoorthy A, La Rosa C. Pores Versus Fibrils: Calcium Ions Regulate Different IAPP-Mediated Membrane Damage Mechanisms Biophysical Journal. 104: 395a. DOI: 10.1016/J.Bpj.2012.11.2202  0.663
2013 Kotler SA, Sciacca MF, Brender JR, Chen J, Yamamoto K, Lee D, Ramamoorthy A. Gangliosides Mediate a Two-Step Mechanism of Membrane Disruption by Beta-Amyloid: Initial Pore Formation Followed by Membrane Fragmentation Biophysical Journal. 104: 217a. DOI: 10.1016/J.Bpj.2012.11.1226  0.842
2012 Krishnamoorthy J, Brender JR, Vivekanandan S, Jahr N, Ramamoorthy A. Side-chain dynamics reveals transient association of Aβ(1-40) monomers with amyloid fibers. The Journal of Physical Chemistry. B. 116: 13618-23. PMID 23116141 DOI: 10.1021/Jp305279W  0.799
2012 Suzuki Y, Brender JR, Hartman K, Ramamoorthy A, Marsh EN. Alternative pathways of human islet amyloid polypeptide aggregation distinguished by (19)f nuclear magnetic resonance-detected kinetics of monomer consumption. Biochemistry. 51: 8154-62. PMID 22998665 DOI: 10.1021/Bi3012548  0.789
2012 Sciacca MF, Brender JR, Lee DK, Ramamoorthy A. Phosphatidylethanolamine enhances amyloid fiber-dependent membrane fragmentation. Biochemistry. 51: 7676-84. PMID 22970795 DOI: 10.1021/bi3009888  0.844
2012 Sciacca MF, Kotler SA, Brender JR, Chen J, Lee DK, Ramamoorthy A. Two-step mechanism of membrane disruption by Aβ through membrane fragmentation and pore formation. Biophysical Journal. 103: 702-10. PMID 22947931 DOI: 10.1016/J.Bpj.2012.06.045  0.832
2012 McHenry AJ, Sciacca MF, Brender JR, Ramamoorthy A. Does cholesterol suppress the antimicrobial peptide induced disruption of lipid raft containing membranes? Biochimica Et Biophysica Acta. 1818: 3019-24. PMID 22885355 DOI: 10.1016/J.Bbamem.2012.07.021  0.798
2012 Brender JR, McHenry AJ, Ramamoorthy A. Does cholesterol play a role in the bacterial selectivity of antimicrobial peptides? Frontiers in Immunology. 3: 195. PMID 22822405 DOI: 10.3389/Fimmu.2012.00195  0.516
2012 Popovych N, Brender JR, Soong R, Vivekanandan S, Hartman K, Basrur V, Macdonald PM, Ramamoorthy A. Site specific interaction of the polyphenol EGCG with the SEVI amyloid precursor peptide PAP(248-286). The Journal of Physical Chemistry. B. 116: 3650-8. PMID 22360607 DOI: 10.1021/Jp2121577  0.812
2012 Huang R, Vivekanandan S, Brender JR, Abe Y, Naito A, Ramamoorthy A. NMR characterization of monomeric and oligomeric conformations of human calcitonin and its interaction with EGCG. Journal of Molecular Biology. 416: 108-20. PMID 22200484 DOI: 10.1016/J.Jmb.2011.12.023  0.658
2012 Brender JR, Salamekh S, Ramamoorthy A. Membrane disruption and early events in the aggregation of the diabetes related peptide IAPP from a molecular perspective. Accounts of Chemical Research. 45: 454-62. PMID 21942864 DOI: 10.1021/Ar200189B  0.657
2012 Popovych N, Brender J, Soong R, Vivekanandan S, Hartman K, Basrur V, MacDonald P, Ramamoorthy A. Backbone and sidechain 1H chemical shifts for PAP248-286 (SEVI) in solution at pH 6 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr18287  0.749
2012 McHenry AJ, Sciacca MF, Brender JR, Hartman K, Ramamoorthy A. The Role of “Raft-Like” Membranes on Antimicrobial Peptide-Lipid Bilayer Interactions Biophysical Journal. 102: 495a. DOI: 10.1016/J.Bpj.2011.11.2712  0.809
2012 Hartman K, Temple S, Popovych N, Monde K, Brender J, Ono A, Ramamoorthy A. Modulating HIV Infection by Controlling the Kinetics of SEVI Fibrillization Biophysical Journal. 102: 254a. DOI: 10.1016/J.Bpj.2011.11.1399  0.805
2012 Brender JR, Subramanian V, Krishnamoorthy J, Sciacca MF, Ramamoorthy A. Tracking Conformational Changes during Amyloidogenesis in Real-Time at Atomic-Resolution by NMR Biophysical Journal. 102: 242a. DOI: 10.1016/J.Bpj.2011.11.1334  0.807
2011 Vivekanandan S, Brender JR, Lee SY, Ramamoorthy A. A partially folded structure of amyloid-beta(1-40) in an aqueous environment. Biochemical and Biophysical Research Communications. 411: 312-6. PMID 21726530 DOI: 10.1016/J.Bbrc.2011.06.133  0.615
2011 Nanga RP, Brender JR, Vivekanandan S, Ramamoorthy A. Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environment. Biochimica Et Biophysica Acta. 1808: 2337-42. PMID 21723249 DOI: 10.1016/J.Bbamem.2011.06.012  0.831
2011 Salamekh S, Brender JR, Hyung SJ, Nanga RP, Vivekanandan S, Ruotolo BT, Ramamoorthy A. A two-site mechanism for the inhibition of IAPP amyloidogenesis by zinc. Journal of Molecular Biology. 410: 294-306. PMID 21616080 DOI: 10.1016/J.Jmb.2011.05.015  0.788
2011 Yoo SI, Yang M, Brender JR, Subramanian V, Sun K, Joo NE, Jeong SH, Ramamoorthy A, Kotov NA. Inhibition of amyloid peptide fibrillation by inorganic nanoparticles: functional similarities with proteins. Angewandte Chemie (International Ed. in English). 50: 5110-5. PMID 21495130 DOI: 10.1002/Anie.201007824  0.585
2011 Brender JR, Lee EL, Hartman K, Wong PT, Ramamoorthy A, Steel DG, Gafni A. Biphasic effects of insulin on islet amyloid polypeptide membrane disruption. Biophysical Journal. 100: 685-92. PMID 21281583 DOI: 10.1016/J.Bpj.2010.09.070  0.819
2011 Brender JR, Nanga RP, Popovych N, Soong R, Macdonald PM, Ramamoorthy A. The amyloidogenic SEVI precursor, PAP248-286, is highly unfolded in solution despite an underlying helical tendency. Biochimica Et Biophysica Acta. 1808: 1161-9. PMID 21262195 DOI: 10.1016/J.Bbamem.2011.01.010  0.83
2011 Zimmerman LB, Worley BV, Palermo EF, Brender JR, Lee KD, Kuroda K, Ramamoorthy A, Meyerhoff ME. Absorbance-based assay for membrane disruption by antimicrobial peptides and synthetic copolymers using pyrroloquinoline quinone-loaded liposomes. Analytical Biochemistry. 411: 194-9. PMID 21237129 DOI: 10.1016/J.Ab.2011.01.009  0.581
2011 McHenry AJ, Brender JR, Hartman K, Ramamoorthy A. Lipid Composition and Raft Domain Formation on the IAPP-Membrane Interaction: The Role of Cholesterol on the Inhibition of IAPP (Amylin) Fibrilization and the Reduction of Membrane Disruption in Model Liposomes and Mouse Pancreatic Islets Biophysical Journal. 100: 541a. DOI: 10.1016/J.Bpj.2010.12.3153  0.816
2011 Salamekh S, Brender JR, Nanga RP, Hyung S, Hartman K, Ruotolo BT, Ramamoorthy A. Molecular Basis of the Interaction Between Zinc and the Amyloidogenic Islet Amyloid Polypeptide Biophysical Journal. 100: 540a-541a. DOI: 10.1016/J.Bpj.2010.12.3152  0.846
2011 Yoo SI, Yang M, Brender JR, Subramanian V, Sun K, Joo NE, Jeong S, Ramamoorthy A, Kotov NA. Inside Cover: Inhibition of Amyloid Peptide Fibrillation by Inorganic Nanoparticles: Functional Similarities with Proteins (Angew. Chem. Int. Ed. 22/2011) Angewandte Chemie International Edition. 50: 4992-4992. DOI: 10.1002/Anie.201102689  0.562
2011 Yoo SI, Yang M, Brender JR, Subramanian V, Sun K, Joo NE, Jeong S, Ramamoorthy A, Kotov NA. Innentitelbild: Inhibition of Amyloid Peptide Fibrillation by Inorganic Nanoparticles: Functional Similarities with Proteins (Angew. Chem. 22/2011) Angewandte Chemie. 123: 5096-5096. DOI: 10.1002/Ange.201102689  0.563
2010 Brender JR, Hartman K, Nanga RP, Popovych N, de la Salud Bea R, Vivekanandan S, Marsh EN, Ramamoorthy A. Role of zinc in human islet amyloid polypeptide aggregation. Journal of the American Chemical Society. 132: 8973-83. PMID 20536124 DOI: 10.1021/Ja1007867  0.82
2010 Smith PE, Brender JR, Dürr UH, Xu J, Mullen DG, Banaszak Holl MM, Ramamoorthy A. Solid-state NMR reveals the hydrophobic-core location of poly(amidoamine) dendrimers in biomembranes. Journal of the American Chemical Society. 132: 8087-97. PMID 20481633 DOI: 10.1021/Ja101524Z  0.807
2010 Brender JR, Hartman K, Gottler LM, Cavitt M, Youngstrom DW, Popovych N, Chapman M, Ramamoorthy A. The Sevi Precursor Peptide PAP248-286, a Dramatic Enhancer of HIV Infectivity, Promotes Lipid Aggregation and Fusion Biophysical Journal. 98: 459a. DOI: 10.1016/J.Bpj.2009.12.2493  0.829
2010 Youngstrom DW, Brender JR, Smith PE, Hartman K, Ramamoorthy A. Formation of Toroidal Pores by Amyloid Proteins: Evidence of Lipid Transbilayer Exchange Induced by Islet Amyloid Polypeptide Biophysical Journal. 98: 458a. DOI: 10.1016/J.Bpj.2009.12.2491  0.83
2010 Nanga RPR, Brender JR, Subramanian V, Popovych N, Ayyalusamy R. Clues for the Mechanism of SEVI HIV Enhancement from Structural Studies of the SEVI Precursor Peptide PAP248-286 in a Membrane Environment by NMR Biophysical Journal. 98: 458a. DOI: 10.1016/J.Bpj.2009.12.2490  0.808
2010 Hartman K, Brender JR, Subramanian V, Youngstrom DW, Ramamoorthy A. Zinc Inhibits Human Islet Amyloid Polypeptide (IAPP) Amyloidogenesis Biophysical Journal. 98: 255a. DOI: 10.1016/J.Bpj.2009.12.1388  0.801
2009 Nanga RP, Brender JR, Vivekanandan S, Popovych N, Ramamoorthy A. NMR structure in a membrane environment reveals putative amyloidogenic regions of the SEVI precursor peptide PAP(248-286). Journal of the American Chemical Society. 131: 17972-9. PMID 19995078 DOI: 10.1021/Ja908170S  0.851
2009 Brender JR, Hartman K, Gottler LM, Cavitt ME, Youngstrom DW, Ramamoorthy A. Helical conformation of the SEVI precursor peptide PAP248-286, a dramatic enhancer of HIV infectivity, promotes lipid aggregation and fusion. Biophysical Journal. 97: 2474-83. PMID 19883590 DOI: 10.1016/J.Bpj.2009.08.034  0.829
2009 Nanga RP, Brender JR, Xu J, Hartman K, Subramanian V, Ramamoorthy A. Three-dimensional structure and orientation of rat islet amyloid polypeptide protein in a membrane environment by solution NMR spectroscopy. Journal of the American Chemical Society. 131: 8252-61. PMID 19456151 DOI: 10.1021/Ja9010095  0.838
2009 Soong R, Brender JR, Macdonald PM, Ramamoorthy A. Association of highly compact type II diabetes related islet amyloid polypeptide intermediate species at physiological temperature revealed by diffusion NMR spectroscopy. Journal of the American Chemical Society. 131: 7079-85. PMID 19405534 DOI: 10.1021/Ja900285Z  0.751
2009 Smith PE, Brender JR, Ramamoorthy A. Induction of negative curvature as a mechanism of cell toxicity by amyloidogenic peptides: the case of islet amyloid polypeptide. Journal of the American Chemical Society. 131: 4470-8. PMID 19278224 DOI: 10.1021/Ja809002A  0.766
2009 Barry J, Fritz M, Brender JR, Smith PE, Lee DK, Ramamoorthy A. Determining the effects of lipophilic drugs on membrane structure by solid-state NMR spectroscopy: the case of the antioxidant curcumin. Journal of the American Chemical Society. 131: 4490-8. PMID 19256547 DOI: 10.1021/Ja809217U  0.811
2009 Brender J, Hartman K, Nanga RP, Le Clair SV, Gottler LM, Ramamoorthy A. An α-Helical Conformation of the SEVI Peptide, a Dramatic Enhancer of HIV Infectivity, Promotes Lipid Aggregation and Fusion Biophysical Journal. 96: 93a-94a. DOI: 10.1016/J.Bpj.2008.12.391  0.832
2009 Nanga RP, Brender JR, Hartman K, Ramamoorthy A. High-resolution Structures of Membrane-Bound IAPP Reveal Functional Implications of the Toxicity of Prefibrillar States of Amyloidogenic Proteins Biophysical Journal. 96: 92a-93a. DOI: 10.1016/J.Bpj.2008.12.385  0.834
2009 Hartman K, Brender JR, Reid KR, Smith PE, Nanga RP, Cavitt MA, Lee EL, Steel DG, Gafni A, Kennedy RT, Ramamoorthy A. A Single Mutation in the Non-Amyloidogenic Region of IAPP Greatly Reduces Toxicity Biophysical Journal. 96: 92a. DOI: 10.1016/J.Bpj.2008.12.383  0.848
2008 Brender JR, Hartman K, Reid KR, Kennedy RT, Ramamoorthy A. A single mutation in the nonamyloidogenic region of islet amyloid polypeptide greatly reduces toxicity. Biochemistry. 47: 12680-8. PMID 18989933 DOI: 10.1021/Bi801427C  0.83
2008 Nanga RP, Brender JR, Xu J, Veglia G, Ramamoorthy A. Structures of rat and human islet amyloid polypeptide IAPP(1-19) in micelles by NMR spectroscopy. Biochemistry. 47: 12689-97. PMID 18989932 DOI: 10.1021/Bi8014357  0.841
2008 Brender JR, Lee EL, Cavitt MA, Gafni A, Steel DG, Ramamoorthy A. Amyloid fiber formation and membrane disruption are separate processes localized in two distinct regions of IAPP, the type-2-diabetes-related peptide. Journal of the American Chemical Society. 130: 6424-9. PMID 18444645 DOI: 10.1021/Ja710484D  0.847
2007 Brender JR, Dürr UH, Heyl D, Budarapu MB, Ramamoorthy A. Membrane fragmentation by an amyloidogenic fragment of human Islet Amyloid Polypeptide detected by solid-state NMR spectroscopy of membrane nanotubes. Biochimica Et Biophysica Acta. 1768: 2026-9. PMID 17662957 DOI: 10.1016/J.Bbamem.2007.07.001  0.846
2005 Brender JR, Dertouzos J, Ballou DP, Massey V, Palfey BA, Entsch B, Steel DG, Gafni A. Conformational dynamics of the isoalloxazine in substrate-free p-hydroxybenzoate hydroxylase: single-molecule studies. Journal of the American Chemical Society. 127: 18171-8. PMID 16366570 DOI: 10.1021/Ja055171O  0.625
2001 Brender JR, Taylor DM, Ramamoorthy A. Orientation of amide-nitrogen-15 chemical shift tensors in peptides: a quantum chemical study. Journal of the American Chemical Society. 123: 914-22. PMID 11456625 DOI: 10.1021/Ja001980Q  0.647
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