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Chenglong Li, Ph.D. - Publications

Affiliations: 
2000 Cornell University, Ithaca, NY, United States 
 2005-2016 Ohio State University, Columbus, Columbus, OH 
 2016- University of Florida, Gainesville, Gainesville, FL, United States 
Area:
Structure and function of proteins using X-ray crystallography
Website:
http://pharmacy.ufl.edu/faculty/chenglong-li/
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114 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Pan L, Chen X, Rassool FV, Li C, Lin J. LLL12B, a Novel Small-Molecule STAT3 Inhibitor, Induces Apoptosis and Suppresses Cell Migration and Tumor Growth in Triple-Negative Breast Cancer Cells. Biomedicines. 10. PMID 36009550 DOI: 10.3390/biomedicines10082003  0.342
2021 Pan L, Zhang R, Ma L, Pierson CR, Finlay JL, Li C, Lin J. STAT3 inhibitor in combination with irradiation significantly inhibits cell viability, cell migration, invasion and tumorsphere growth of human medulloblastoma cells. Cancer Biology & Therapy. 1-10. PMID 34254873 DOI: 10.1080/15384047.2021.1951573  0.339
2021 Zhang R, Yang X, Roque DM, Li C, Lin J. A novel small molecule LLL12B inhibits STAT3 signaling and sensitizes ovarian cancer cell to paclitaxel and cisplatin. Plos One. 16: e0240145. PMID 33909625 DOI: 10.1371/journal.pone.0240145  0.308
2021 Chen X, Pan L, Wei J, Zhang R, Yang X, Song J, Bai RY, Fu S, Pierson CR, Finlay JL, Li C, Lin J. LLL12B, a small molecule STAT3 inhibitor, induces growth arrest, apoptosis, and enhances cisplatin-mediated cytotoxicity in medulloblastoma cells. Scientific Reports. 11: 6517. PMID 33753770 DOI: 10.1038/s41598-021-85888-x  0.312
2020 Pan L, Chen X, Fu S, Yu W, Li C, Wang T, Lo HW, Lin J. LLY17, a novel small molecule STAT3 inhibitor induces apoptosis and suppresses cell migration and tumor growth in triple-negative breast cancer. Breast Cancer Research and Treatment. PMID 32240456 DOI: 10.1007/S10549-020-05613-6  0.595
2018 Al-Awadhi FH, Gao B, Rezaei MA, Kwan JC, Li C, Ye T, Paul VJ, Luesch H. Discovery, Synthesis, Pharmacological Profiling, and Biological Characterization of Brintonamides A-E, Novel Dual Protease and GPCR Modulators from a Marine Cyanobacterium. Journal of Medicinal Chemistry. PMID 30015488 DOI: 10.1021/Acs.Jmedchem.8B00885  0.306
2017 Chen X, Wei J, Li C, Pierson CR, Finlay JL, Lin J. Blocking interleukin-6 signaling inhibits cell viability/proliferation, glycolysis, and colony forming activity of human medulloblastoma cells. International Journal of Oncology. PMID 29207075 DOI: 10.3892/ijo.2017.4211  0.307
2017 Liu T, Ma H, Shi W, Duan J, Wang Y, Zhang C, Li C, Lin J, Li S, Lv J, Lin L. Inhibition of STAT3 signaling pathway by ursolic acid suppresses growth of hepatocellular carcinoma. International Journal of Oncology. 51: 555-562. PMID 28714512 DOI: 10.3892/ijo.2017.4035  0.306
2017 Wang Y, Ma H, Zhao C, Liu T, Yan D, Jou D, Li H, Zhang C, Lü J, Li C, Lin J, Li S, Lin L. Growth-suppressive activity of raloxifene on liver cancer cells by targeting IL-6/GP130 signaling. Oncotarget. PMID 28430601 DOI: 10.18632/Oncotarget.16898  0.382
2017 Sugimoto Y, Sawant DB, Fisk HA, Mao L, Li C, Chettiar S, Li PK, Darby MV, Brueggemeier RW. Novel pyrrolopyrimidines as Mps1/TTK kinase inhibitors for breast cancer. Bioorganic & Medicinal Chemistry. PMID 28259529 DOI: 10.1016/J.Bmc.2017.02.030  0.39
2017 Narayanasamy S, Sun J, Pavlovicz RE, Eroglu A, Rush CE, Sunkel BD, Li C, Harrison EH, Curley RW. Synthesis of Apo-13-, and Apo-15-Lycopenoids, Cleavage Products of Lycopene that are Retinoic Acid Antagonists. Journal of Lipid Research. PMID 28250025 DOI: 10.1194/Jlr.D073148  0.302
2017 Yu W, Li C, Zhang W, Xia Y, Li S, Lin J, Yu K, Liu M, Yang L, Luo JG, Chen Y, Sun H, Kong LY. Discovery of an Orally Selective Inhibitor of Signal Transducer and Activator of Transcription 3 Using Advanced Multiple Ligand Simultaneous Docking. Journal of Medicinal Chemistry. PMID 28245116 DOI: 10.1021/Acs.Jmedchem.6B01489  0.664
2017 Tian J, Xiao H, Wu R, Cao Y, Li C, Xu R, Pierson CR, Finlay JL, Yang F, Gu N, Lin J. The Antiproliferative and Colony-suppressive Activities of STAT3 Inhibitors in Human Cancer Cells Is Compromised Under Hypoxic Conditions. Anticancer Research. 37: 547-553. PMID 28179300 DOI: 10.21873/Anticanres.11347  0.44
2017 Webb LM, Amici SA, Jablonski KA, Savardekar H, Panfil AR, Li L, Zhou W, Peine K, Karkhanis V, Bachelder EM, Ainslie KM, Green PL, Li C, Baiocchi RA, Guerau-de-Arellano M. PRMT5-Selective Inhibitors Suppress Inflammatory T Cell Responses and Experimental Autoimmune Encephalomyelitis. Journal of Immunology (Baltimore, Md. : 1950). PMID 28087667 DOI: 10.4049/Jimmunol.1601702  0.363
2016 Lin L, Jou D, Wang Y, Ma H, Liu T, Fuchs J, Li PK, Lü J, Li C, Lin J. STAT3 as a potential therapeutic target in ALDH+ and CD44+/CD24+ stem cell-like pancreatic cancer cells. International Journal of Oncology. PMID 27748818 DOI: 10.3892/Ijo.2016.3728  0.338
2016 Zhao J, Yu H, Liu Y, Gibson SA, Yan Z, Xu X, Gaggar A, Li PK, Li C, Wei S, Benveniste EN, Qin H. Protective Effect of Suppressing STAT3 Activity in LPS-induced Acute Lung Injury. American Journal of Physiology. Lung Cellular and Molecular Physiology. ajplung.00281.2016. PMID 27638904 DOI: 10.1152/Ajplung.00281.2016  0.309
2016 Patel PA, Kvaratskhelia N, Mansour Y, Antwi J, Feng L, Koneru P, Kobe MJ, Jena N, Shi G, Mohamed MS, Li C, Kessl JJ, Fuchs JR. Indole-based allosteric inhibitors of HIV-1 integrase. Bioorganic & Medicinal Chemistry Letters. PMID 27568085 DOI: 10.1016/J.Bmcl.2016.08.037  0.337
2016 Wu X, Cao Y, Xiao H, Li C, Lin J. Bazedoxifene as a Novel GP130 Inhibitor for Pancreatic Cancer Therapy. Molecular Cancer Therapeutics. PMID 27535971 DOI: 10.1158/1535-7163.Mct-15-0921  0.392
2016 Wang Y, Zhao C, Ma H, Li H, Lu J, Li C, Lin J, Lin L. Abstract 4562: Inhibition of STAT3 signaling in human liver cancer cells using Evista Cancer Research. 76: 4562-4562. DOI: 10.1158/1538-7445.Am2016-4562  0.4
2015 Tarighat SS, Santhanam R, Frankhouser D, Radomska HS, Lai H, Anghelina M, Wang H, Huang X, Alinari L, Walker A, Caligiuri MA, Croce CM, Li L, Garzon R, Li C, et al. The dual epigenetic role of PRMT5 in acute myeloid leukemia: gene activation and repression via histone arginine methylation. Leukemia. PMID 26536822 DOI: 10.1038/Leu.2015.308  0.343
2015 Zhao C, Xiao H, Wu X, Li C, Liang G, Yang S, Lin J. Rational combination of MEK inhibitor and the STAT3 pathway modulator for the therapy in K-Ras mutated pancreatic and colon cancer cells. Oncotarget. 6: 14472-87. PMID 25961376 DOI: 10.18632/Oncotarget.3991  0.367
2015 Zuo M, Li C, Lin J, Javle M. LLL12, a novel small inhibitor targeting STAT3 for hepatocellular carcinoma therapy. Oncotarget. 6: 10940-9. PMID 25883212 DOI: 10.18632/Oncotarget.3458  0.347
2015 Alinari L, Mahasenan KV, Yan F, Karkhanis V, Chung JH, Smith EM, Quinion C, Smith PL, Kim L, Patton JT, Lapalombella R, Yu B, Wu Y, Roy S, De Leo A, ... ... Li C, et al. Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation. Blood. 125: 2530-43. PMID 25742700 DOI: 10.1182/Blood-2014-12-619783  0.695
2015 Xiao H, Bid HK, Jou D, Wu X, Yu W, Li C, Houghton PJ, Lin J. A novel small molecular STAT3 inhibitor, LY5, inhibits cell viability, cell migration, and angiogenesis in medulloblastoma cells. The Journal of Biological Chemistry. 290: 3418-29. PMID 25313399 DOI: 10.1074/Jbc.M114.616748  0.666
2015 Wu X, Xiao H, Li C, Lin J. Abstract 2050: Persistent STAT3 signaling contributes to the resistance of anti cancer drugs doxorubicin and cisplatin, and MEK inhibitor AZD6244 in human sarcoma cells Cancer Research. 75: 2050-2050. DOI: 10.1158/1538-7445.Am2015-2050  0.457
2015 Wu X, Xiao H, Li C, Lin J. Abstract A177: Repositioning Bazedoxifene as a novel inhibitor of IL-6/GP130 signaling for pancreatic cancer therapy Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-A177  0.347
2014 Rao W, Zhang W, Poventud-Fuentes I, Wang Y, Lei Y, Agarwal P, Weekes B, Li C, Lu X, Yu J, He X. Thermally responsive nanoparticle-encapsulated curcumin and its combination with mild hyperthermia for enhanced cancer cell destruction. Acta Biomaterialia. 10: 831-42. PMID 24516867 DOI: 10.1016/J.Actbio.2013.10.020  0.34
2014 Li H, Xiao H, Lin L, Jou D, Kumari V, Lin J, Li C. Drug design targeting protein-protein interactions (PPIs) using multiple ligand simultaneous docking (MLSD) and drug repositioning: discovery of raloxifene and bazedoxifene as novel inhibitors of IL-6/GP130 interface. Journal of Medicinal Chemistry. 57: 632-41. PMID 24456369 DOI: 10.1021/Jm401144Z  0.373
2014 Yan F, Alinari L, Lustberg ME, Martin LK, Cordero-Nieves HM, Banasavadi-Siddegowda Y, Virk S, Barnholtz-Sloan J, Bell EH, Wojton J, Jacob NK, Chakravarti A, Nowicki MO, Wu X, Lapalombella R, ... ... Li C, et al. Genetic validation of the protein arginine methyltransferase PRMT5 as a candidate therapeutic target in glioblastoma. Cancer Research. 74: 1752-65. PMID 24453002 DOI: 10.1158/0008-5472.Can-13-0884  0.397
2014 Yang J, Keenan K, Mace T, Ferren M, Bekaii-Saab T, Fuchs J, Schwartz E, Li C, Pui-Kai Li JL, Lesinski G. Cholangiocarcinoma cells secrete soluble factors that activate Jak/STAT signal transduction and promote MDSC expansion Journal For Immunotherapy of Cancer. 2. DOI: 10.1186/2051-1426-2-S3-P271  0.324
2014 Sharma S, Wu X, Smith P, Denko N, Li C, Lai H, Yan F, Shilo K, Chakravarti A, Sif S, Baiocchi R, Otterson G, Xu-Welliver M. Abstract 854: Inhibition of PRMT5 results in radiosensitization in lung cancer cell lines Cancer Research. 74: 854-854. DOI: 10.1158/1538-7445.Am2014-854  0.38
2014 Xiao H, Bian Y, Zhao C, Lin L, Jou D, Li H, Li C, Lin J. Abstract 4598: GP130 as a novel therapeutic target in il-6-dependent cancers Cancer Research. 74: 4598-4598. DOI: 10.1158/1538-7445.Am2014-4598  0.399
2014 Yang J, Keenan K, Mace T, Bekaii-Saab T, Fuchs J, Schwartz E, Li C, Lin J, Li P, Lesinski G. Abstract 4073: STAT3 inhibitors elicit direct anti-tumor effects against human biliary caner cell lines and limit release of immune suppressive cytokinesin vitro Cancer Research. 74: 4073-4073. DOI: 10.1158/1538-7445.Am2014-4073  0.431
2014 Yu W, Li C. Regioselective one-pot C-N coupling of substituted naphthoquinones: Selective intramolecular ring fusion of sulfonamides Tetrahedron. 70: 459-464. DOI: 10.1016/J.Tet.2013.11.041  0.553
2013 Chettiar SN, Cooley JV, Park IH, Bhasin D, Chakravarti A, Li PK, Li C, Jacob NK. Design, synthesis and biological studies of survivin dimerization modulators that prolong mitotic cycle. Bioorganic & Medicinal Chemistry Letters. 23: 5429-33. PMID 23968825 DOI: 10.1016/J.Bmcl.2013.07.034  0.402
2013 Kroon P, Berry PA, Stower MJ, Rodrigues G, Mann VM, Simms M, Bhasin D, Chettiar S, Li C, Li PK, Maitland NJ, Collins AT. JAK-STAT blockade inhibits tumor initiation and clonogenic recovery of prostate cancer stem-like cells. Cancer Research. 73: 5288-98. PMID 23824741 DOI: 10.1158/0008-5472.Can-13-0874  0.335
2013 Yi B, Long S, González-Cestari TF, Henderson BJ, Pavlovicz RE, Werbovetz K, Li C, McKay DB. Discovery of benzamide analogs as negative allosteric modulators of human neuronal nicotinic receptors: pharmacophore modeling and structure-activity relationship studies. Bioorganic & Medicinal Chemistry. 21: 4730-43. PMID 23757208 DOI: 10.1016/J.Bmc.2013.03.082  0.371
2013 Yu W, Xiao H, Lin J, Li C. Discovery of novel STAT3 small molecule inhibitors via in silico site-directed fragment-based drug design. Journal of Medicinal Chemistry. 56: 4402-12. PMID 23651330 DOI: 10.1021/Jm400080C  0.667
2013 Yu W, Li C. 4-Nitro-phenyl N-(2-sulfamoylphen-yl)carbamate. Acta Crystallographica. Section E, Structure Reports Online. 69: o355. PMID 23476546 DOI: 10.1107/S1600536813003310  0.494
2013 Still PC, Yi B, González-Cestari TF, Pan L, Pavlovicz RE, Chai HB, Ninh TN, Li C, Soejarto DD, McKay DB, Kinghorn AD. Alkaloids from Microcos paniculata with cytotoxic and nicotinic receptor antagonistic activities. Journal of Natural Products. 76: 243-9. PMID 23327794 DOI: 10.1021/Np3007414  0.353
2013 Guvenc H, Pavlyukov MS, Joshi K, Kurt H, Banasavadi-Siddegowda YK, Mao P, Hong C, Yamada R, Kwon CH, Bhasin D, Chettiar S, Kitange G, Park IH, Sarkaria JN, Li C, et al. Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complex. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 631-42. PMID 23251006 DOI: 10.1158/1078-0432.Ccr-12-0647  0.384
2013 Endeshaw M, Zhu X, He S, Pandharkar T, Cason E, Mahasenan KV, Agarwal H, Li C, Munde M, Wilson WD, Bahar M, Doskotch RW, Kinghorn AD, Kaiser M, Brun R, et al. 8,8-dialkyldihydroberberines with potent antiprotozoal activity. Journal of Natural Products. 76: 311-5. PMID 23167812 DOI: 10.1021/Np300638F  0.669
2013 Gaudio E, Paduano F, Ngankeu A, Lovat F, Fabbri M, Sun HL, Gasparini P, Efanov A, Peng Y, Zanesi N, Shuaib MA, Rassenti LZ, Kipps TJ, Li C, Aqeilan RI, et al. Heat shock protein 70 regulates Tcl1 expression in leukemia and lymphomas. Blood. 121: 351-9. PMID 23160471 DOI: 10.1182/Blood-2012-09-457374  0.33
2013 Yan F, Gordon K, Mahasenan K, Lustberg M, Alinari L, Earl CT, Kaur B, Li C, Baiocchi RA. Abstract 4637: Developing a first in class of drug to inhibit protein arginine methyltransferase 5 (PRMT5) enzyme dysregulation in glioblastoma multiforme. Cancer Research. 73: 4637-4637. DOI: 10.1158/1538-7445.Am2013-4637  0.738
2013 Xiao H, Yu W, Olson VR, Li C, Houghton P, Lin J. Abstract 3252: A novel small molecule, LY5, selectively inhibits STAT3 phosphorylation and activities and exhibits potent growth suppressive activity in cancer cells. Cancer Research. 73: 3252-3252. DOI: 10.1158/1538-7445.Am2013-3252  0.673
2013 Tarighat SS, Mahasenan K, Perrotti D, Garzon R, Caligiuri M, Li C, Blum W, Marcucci G, Baiocchi RA. Abstract 1128: Preclinical and pharmacological activities of protein arginine methyltransferase 5(PRMT5) enzyme inhibition in acute myeloid leukemia . Cancer Research. 73: 1128-1128. DOI: 10.1158/1538-7445.Am2013-1128  0.73
2012 Liu A, Liu Y, Jin Z, Hu Q, Lin L, Jou D, Yang J, Xu Z, Wang H, Li C, Lin J. XZH-5 inhibits STAT3 phosphorylation and enhances the cytotoxicity of chemotherapeutic drugs in human breast and pancreatic cancer cells. Plos One. 7: e46624. PMID 23056374 DOI: 10.1371/Journal.Pone.0046624  0.434
2012 Henderson BJ, González-Cestari TF, Yi B, Pavlovicz RE, Boyd RT, Li C, Bergmeier SC, McKay DB. Defining the putative inhibitory site for a selective negative allosteric modulator of human α4β2 neuronal nicotinic receptors. Acs Chemical Neuroscience. 3: 682-92. PMID 23019495 DOI: 10.1021/Cn300035F  0.311
2012 Bill MA, Nicholas C, Mace TA, Etter JP, Li C, Schwartz EB, Fuchs JR, Young GS, Lin L, Lin J, He L, Phelps M, Li PK, Lesinski GB. Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines. Plos One. 7: e40724. PMID 22899991 DOI: 10.1371/Journal.Pone.0040724  0.436
2012 Mahasenan KV, Li C. Novel inhibitor discovery through virtual screening against multiple protein conformations generated via ligand-directed modeling: a maternal embryonic leucine zipper kinase example. Journal of Chemical Information and Modeling. 52: 1345-55. PMID 22540736 DOI: 10.1021/Ci300040C  0.695
2012 Bid HK, Oswald D, Li C, London CA, Lin J, Houghton PJ. Anti-angiogenic activity of a small molecule STAT3 inhibitor LLL12. Plos One. 7: e35513. PMID 22530037 DOI: 10.1371/Journal.Pone.0035513  0.372
2012 Dewan V, Liu T, Chen KM, Qian Z, Xiao Y, Kleiman L, Mahasenan KV, Li C, Matsuo H, Pei D, Musier-Forsyth K. Cyclic peptide inhibitors of HIV-1 capsid-human lysyl-tRNA synthetase interaction. Acs Chemical Biology. 7: 761-9. PMID 22276994 DOI: 10.1021/Cb200450W  0.666
2012 Lin L, Benson DM, DeAngelis S, Bakan CE, Li PK, Li C, Lin J. A small molecule, LLL12 inhibits constitutive STAT3 and IL-6-induced STAT3 signaling and exhibits potent growth suppressive activity in human multiple myeloma cells. International Journal of Cancer. Journal International Du Cancer. 130: 1459-69. PMID 21520044 DOI: 10.1002/Ijc.26152  0.414
2012 Onimoe GI, Liu A, Lin L, Wei CC, Schwartz EB, Bhasin D, Li C, Fuchs JR, Li PK, Houghton P, Termuhlen A, Gross T, Lin J. Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice. Investigational New Drugs. 30: 916-26. PMID 21340507 DOI: 10.1007/S10637-011-9645-1  0.417
2012 Alinari L, Yan F, Smith P, Patton JT, Quinion C, Yu B, Earl CT, Lustberg ME, Villagomez L, Hertlein EK, Byrd JC, Ayers L, Motiwala T, Majumder S, Li C, et al. Protein Arginine Methyltransferase 5 (PRMT5) Over-Expression Is Essential for Epstein-Barr Virus-Driven B-Cell Transformation. Blood. 120: 2378-2378. DOI: 10.1182/Blood.V120.21.2378.2378  0.37
2012 Lin L, Li H, Xu M, Zhao Z, Olson V, Xu Y, Li C, Lin J. Abstract 4772: Novel drug discovery approach targeting STAT3 for breast cancer therapy using MLSD and drug repositioning Cancer Research. 72: 4772-4772. DOI: 10.1158/1538-7445.Am2012-4772  0.419
2012 Cooley JV, Chettiar S, Park I, Bhasin D, Chakravarti A, Kai LP, Li C, Jacob NK. Abstract 3049: Development of novel survivin inhibitors to target mitotic machinery in cancers Cancer Research. 72: 3049-3049. DOI: 10.1158/1538-7445.Am2012-3049  0.444
2012 Bid HK, Oswald D, Li C, Lin J, Houghton PJ. Abstract 2317: Direct anti-angiogenic activity of a small molecular STAT3 inhibitor LLL12 Cancer Research. 72: 2317-2317. DOI: 10.1158/1538-7445.Am2012-2317  0.348
2012 Kroon P, Berry P, Bhasin D, Li C, Li P, Stower M, Mann V, Simms M, Maitland N, Collins A. 301 Interleukin-6 Expression and JAK-STat Signalling in Prostate Cancer Stem Cells European Journal of Cancer. 48: S74. DOI: 10.1016/S0959-8049(12)70995-4  0.303
2011 Mahasenan KV, Pavlovicz RE, Henderson BJ, González-Cestari TF, Yi B, McKay DB, Li C. Discovery of Novel α4β2 Neuronal Nicotinic Receptor Modulators through Structure-Based Virtual Screening. Acs Medicinal Chemistry Letters. 2: 855-60. PMID 24936233 DOI: 10.1021/Ml2001714  0.682
2011 Lin L, Fuchs J, Li C, Olson V, Bekaii-Saab T, Lin J. STAT3 signaling pathway is necessary for cell survival and tumorsphere forming capacity in ALDH⁺/CD133⁺ stem cell-like human colon cancer cells. Biochemical and Biophysical Research Communications. 416: 246-51. PMID 22074823 DOI: 10.1016/J.Bbrc.2011.10.112  0.388
2011 Henderson BJ, Carper DJ, González-Cestari TF, Yi B, Mahasenan K, Pavlovicz RE, Dalefield ML, Coleman RS, Li C, McKay DB. Structure-activity relationship studies of sulfonylpiperazine analogues as novel negative allosteric modulators of human neuronal nicotinic receptors. Journal of Medicinal Chemistry. 54: 8681-92. PMID 22060139 DOI: 10.1021/Jm201294R  0.662
2011 Pavlovicz RE, Henderson BJ, Bonnell AB, Boyd RT, McKay DB, Li C. Identification of a negative allosteric site on human α4β2 and α3β4 neuronal nicotinic acetylcholine receptors. Plos One. 6: e24949. PMID 21949802 DOI: 10.1371/Journal.Pone.0024949  0.316
2011 Lin L, Liu A, Peng Z, Lin HJ, Li PK, Li C, Lin J. STAT3 is necessary for proliferation and survival in colon cancer-initiating cells. Cancer Research. 71: 7226-37. PMID 21900397 DOI: 10.1158/0008-5472.Can-10-4660  0.403
2011 Li H, Liu A, Zhao Z, Xu Y, Lin J, Jou D, Li C. Fragment-based drug design and drug repositioning using multiple ligand simultaneous docking (MLSD): identifying celecoxib and template compounds as novel inhibitors of signal transducer and activator of transcription 3 (STAT3). Journal of Medicinal Chemistry. 54: 5592-6. PMID 21678971 DOI: 10.1021/Jm101330H  0.363
2011 Ball S, Li C, Li PK, Lin J. The small molecule, LLL12, inhibits STAT3 phosphorylation and induces apoptosis in medulloblastoma and glioblastoma cells. Plos One. 6: e18820. PMID 21526200 DOI: 10.1371/Journal.Pone.0018820  0.438
2011 Liu Y, Liu A, Li H, Li C, Lin J. Celecoxib inhibits interleukin-6/interleukin-6 receptor-induced JAK2/STAT3 phosphorylation in human hepatocellular carcinoma cells. Cancer Prevention Research (Philadelphia, Pa.). 4: 1296-305. PMID 21490132 DOI: 10.1158/1940-6207.Capr-10-0317  0.317
2011 Fossey SL, Bear MD, Lin J, Li C, Schwartz EB, Li PK, Fuchs JR, Fenger J, Kisseberth WC, London CA. The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines. Bmc Cancer. 11: 112. PMID 21443800 DOI: 10.1186/1471-2407-11-112  0.441
2011 Liu A, Liu Y, Xu Z, Yu W, Wang H, Li C, Lin J. Novel small molecule, XZH-5, inhibits constitutive and interleukin-6-induced STAT3 phosphorylation in human rhabdomyosarcoma cells. Cancer Science. 102: 1381-7. PMID 21435102 DOI: 10.1111/J.1349-7006.2011.01932.X  0.667
2011 Reed S, Li H, Li C, Lin J. Celecoxib inhibits STAT3 phosphorylation and suppresses cell migration and colony forming ability in rhabdomyosarcoma cells. Biochemical and Biophysical Research Communications. 407: 450-5. PMID 21397587 DOI: 10.1016/J.Bbrc.2011.03.014  0.426
2011 Park IH, Li C. Characterization of molecular recognition of STAT3 SH2 domain inhibitors through molecular simulation. Journal of Molecular Recognition : Jmr. 24: 254-65. PMID 21360612 DOI: 10.1002/Jmr.1047  0.356
2011 Liu Y, Liu A, Xu Z, Yu W, Wang H, Li C, Lin J. XZH-5 inhibits STAT3 phosphorylation and causes apoptosis in human hepatocellular carcinoma cells. Apoptosis : An International Journal On Programmed Cell Death. 16: 502-10. PMID 21311975 DOI: 10.1007/S10495-011-0578-0  0.632
2011 Wei CC, Ball S, Lin L, Liu A, Fuchs JR, Li PK, Li C, Lin J. Two small molecule compounds, LLL12 and FLLL32, exhibit potent inhibitory activity on STAT3 in human rhabdomyosarcoma cells. International Journal of Oncology. 38: 279-85. PMID 21109950 DOI: 10.3892/Ijo_00000848  0.453
2011 Yan F, Smith P, Alinari L, Ryu J, Yu B, Karkhanis V, Tae S, Patton JT, Wilding EE, Gordon K, Mahasenan K, Bhasin D, Agostinelli C, Pileri SA, Byrd JC, ... ... Li C, et al. Developing a Novel Class of Drug to Inhibit Protein Arginine Methyltransferase 5 (PRMT5) Enzyme Dysregulation in Mantle Cell Lymphoma Blood. 118: 595-595. DOI: 10.1182/Blood.V118.21.595.595  0.74
2011 Nicholas C, Yan F, Peters SB, Bill MA, Li P, Li C, Fuchs JR, Baiocchi R, Lesinski GB. Abstract 933: The expression of PRMT5 methyltransferase mediates cell survival and metastatic phenotype in malignant melanoma Cancer Research. 71: 933-933. DOI: 10.1158/1538-7445.Am2011-933  0.393
2011 Liu A, Liu Y, Xu Z, Yu W, Wang H, Li C, Lin J. Abstract 5345: A novel small molecule, XZH-5 inhibits constitutive and interleukin-6-induced STAT3 phosphorylation in human rhabdomyosarcoma cells Cancer Research. 71: 5345-5345. DOI: 10.1158/1538-7445.Am2011-5345  0.679
2011 Demir H, Ray-Chaudhury A, Li T, Li C, Nakano I. Abstract 3299: Targeting therapy-resistant glioma cells with novel compounds that inhibit action of survivin Cancer Research. 71: 3299-3299. DOI: 10.1158/1538-7445.Am2011-3299  0.388
2011 Lin L, Li P, Fuchs J, Li C, Lin J. Abstract 2444: STAT3 is necessary for proliferation and survival in pancreatic cancer-initiating cells Cancer Research. 71: 2444-2444. DOI: 10.1158/1538-7445.Am2011-2444  0.364
2011 Liu A, Li H, Xu M, Zhao Z, McWilliams E, Xu Y, Li C, Lin J. Abstract A223: Novel drug development approach targeting STAT3 for sarcoma therapy using MLSD and drug reposition. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-A223  0.406
2010 Liu Y, Li C, Lin J. STAT3 as a Therapeutic Target for Glioblastoma. Anti-Cancer Agents in Medicinal Chemistry. 10: 512-9. PMID 20879983 DOI: 10.2174/187152010793498636  0.362
2010 Liu Y, Fuchs J, Li C, Lin J. IL-6, a risk factor for hepatocellular carcinoma: FLLL32 inhibits IL-6-induced STAT3 phosphorylation in human hepatocellular cancer cells. Cell Cycle (Georgetown, Tex.). 9: 3423-7. PMID 20818158 DOI: 10.4161/Cc.9.17.12946  0.322
2010 Lin L, Deangelis S, Foust E, Fuchs J, Li C, Li PK, Schwartz EB, Lesinski GB, Benson D, Lü J, Hoyt D, Lin J. A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells. Molecular Cancer. 9: 217. PMID 20712901 DOI: 10.1186/1476-4598-9-217  0.443
2010 Bill MA, Fuchs JR, Li C, Yui J, Bakan C, Benson DM, Schwartz EB, Abdelhamid D, Lin J, Hoyt DG, Fossey SL, Young GS, Carson WE, Li PK, Lesinski GB. The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity. Molecular Cancer. 9: 165. PMID 20576164 DOI: 10.1186/1476-4598-9-165  0.407
2010 Liu Y, Li PK, Li C, Lin J. Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL-6 in human liver cancer cells. The Journal of Biological Chemistry. 285: 27429-39. PMID 20562100 DOI: 10.1074/Jbc.M110.142752  0.34
2010 Henderson BJ, Pavlovicz RE, Allen JD, González-Cestari TF, Orac CM, Bonnell AB, Zhu MX, Boyd RT, Li C, Bergmeier SC, McKay DB. Negative allosteric modulators that target human alpha4beta2 neuronal nicotinic receptors. The Journal of Pharmacology and Experimental Therapeutics. 334: 761-74. PMID 20551292 DOI: 10.1124/Jpet.110.168211  0.373
2010 Park IH, Li C. Dynamic ligand-induced-fit simulation via enhanced conformational samplings and ensemble dockings: a survivin example. The Journal of Physical Chemistry. B. 114: 5144-53. PMID 20337446 DOI: 10.1021/Jp911085D  0.319
2010 Lin L, Hutzen B, Zuo M, Ball S, Deangelis S, Foust E, Pandit B, Ihnat MA, Shenoy SS, Kulp S, Li PK, Li C, Fuchs J, Lin J. Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells. Cancer Research. 70: 2445-54. PMID 20215512 DOI: 10.1158/0008-5472.Can-09-2468  0.459
2010 Lin L, Hutzen B, Li PK, Ball S, Zuo M, DeAngelis S, Foust E, Sobo M, Friedman L, Bhasin D, Cen L, Li C, Lin J. A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells. Neoplasia (New York, N.Y.). 12: 39-50. PMID 20072652 DOI: 10.1593/Neo.91196  0.474
2010 Fotie J, Kaiser M, Delfín DA, Manley J, Reid CS, Paris JM, Wenzler T, Maes L, Mahasenan KV, Li C, Werbovetz KA. Antitrypanosomal activity of 1,2-dihydroquinolin-6-ols and their ester derivatives. Journal of Medicinal Chemistry. 53: 966-82. PMID 20047276 DOI: 10.1021/Jm900723W  0.673
2010 Lin L, Li C, Li P, Fuchs J, Lin J. Abstract A100: STAT3 as a novel cancer prevention target in colorectal cancer stem cells Cancer Prevention Research. 3. DOI: 10.1158/1940-6207.Prev-10-A100  0.39
2010 Zuo M, Lin L, Liu Y, DeAngelis S, Ball S, Li P, Li C, Lin J. Abstract B95: A novel small molecule, LLL12 inhibits STAT3 phosphorylation and activities and exhibits potent growth suppressive activity in human hepatocellular carcinoma cells Cancer Prevention Research. 3. DOI: 10.1158/1940-6207.Prev-09-B95  0.388
2010 Abdelhamid D, Corcoran M, Etter JP, Hu S, Pandit B, Li C, Li P, Fuchs JR. Abstract 4502: Synthesis and evaluation of curcumin-like compounds as inhibitors of the JAK/STAT pathway in cancer Cancer Research. 70: 4502-4502. DOI: 10.1158/1538-7445.Am10-4502  0.461
2010 Lin L, Hutzen B, Peng Z, Lin H, Li P, Li C, Wicha M, Lin J. Abstract 4296: STAT3 is required for proliferation and tumor growth of breast cancer stem cells Cancer Research. 70: 4296-4296. DOI: 10.1158/1538-7445.Am10-4296  0.349
2010 Liu Y, Li P, Li C, Lin J. Abstract 2275: A novel small molecule, LLL12, inhibits IL-6 induced STAT3 phosphorylation and nuclear translocation Cancer Research. 70: 2275-2275. DOI: 10.1158/1538-7445.Am10-2275  0.384
2009 Lin L, Hutzen B, Ball S, Foust E, Sobo M, Deangelis S, Pandit B, Friedman L, Li C, Li PK, Fuchs J, Lin J. New curcumin analogues exhibit enhanced growth-suppressive activity and inhibit AKT and signal transducer and activator of transcription 3 phosphorylation in breast and prostate cancer cells. Cancer Science. 100: 1719-27. PMID 19558577 DOI: 10.1111/J.1349-7006.2009.01220.X  0.438
2009 Tiwari R, Mahasenan K, Pavlovicz R, Li C, Tjarks W. Carborane clusters in computational drug design: a comparative docking evaluation using AutoDock, FlexX, Glide, and Surflex. Journal of Chemical Information and Modeling. 49: 1581-9. PMID 19449853 DOI: 10.1021/Ci900031Y  0.666
2009 Friedman L, Lin L, Ball S, Bekaii-Saab T, Fuchs J, Li PK, Li C, Lin J. Curcumin analogues exhibit enhanced growth suppressive activity in human pancreatic cancer cells. Anti-Cancer Drugs. 20: 444-9. PMID 19384191 DOI: 10.1097/Cad.0B013E32832Afc04  0.415
2009 Cen L, Hutzen B, Ball S, DeAngelis S, Chen CL, Fuchs JR, Li C, Li PK, Lin J. New structural analogues of curcumin exhibit potent growth suppressive activity in human colorectal carcinoma cells. Bmc Cancer. 9: 99. PMID 19331692 DOI: 10.1186/1471-2407-9-99  0.33
2009 Fuchs JR, Pandit B, Bhasin D, Etter JP, Regan N, Abdelhamid D, Li C, Lin J, Li PK. Structure-activity relationship studies of curcumin analogues. Bioorganic & Medicinal Chemistry Letters. 19: 2065-9. PMID 19249204 DOI: 10.1016/J.Bmcl.2009.01.104  0.354
2009 Liu Z, Liu S, Xie Z, Pavlovicz RE, Wu J, Chen P, Aimiuwu J, Pang J, Bhasin D, Neviani P, Fuchs JR, Plass C, Li PK, Li C, Huang TH, et al. Modulation of DNA methylation by a sesquiterpene lactone parthenolide. The Journal of Pharmacology and Experimental Therapeutics. 329: 505-14. PMID 19201992 DOI: 10.1124/Jpet.108.147934  0.372
2009 Liu Z, Xie Z, Jones W, Pavlovicz RE, Liu S, Yu J, Li PK, Lin J, Fuchs JR, Marcucci G, Li C, Chan KK. Curcumin is a potent DNA hypomethylation agent. Bioorganic & Medicinal Chemistry Letters. 19: 706-9. PMID 19112019 DOI: 10.1016/J.Bmcl.2008.12.041  0.352
2009 González-Cestari TF, Henderson BJ, Pavlovicz RE, McKay SB, El-Hajj RA, Pulipaka AB, Orac CM, Reed DD, Boyd RT, Zhu MX, Li C, Bergmeier SC, McKay DB. Effect of novel negative allosteric modulators of neuronal nicotinic receptors on cells expressing native and recombinant nicotinic receptors: implications for drug discovery. The Journal of Pharmacology and Experimental Therapeutics. 328: 504-15. PMID 18984653 DOI: 10.1124/Jpet.108.144576  0.374
2009 Liu S, Wu LC, Pang J, Santhanam R, Schwind S, Wu Y, Hickey C, Yu J, Mishra A, Becker H, Li C, Briesewitz R, Baiocchi RA, Chan KK, Caligiuri MA, et al. Evidence of MicroRNA-29b and Sp1/NFκB-HDAC Regulatory Network for KIT Expression in KIT-Driven Acute Myeloid Leukemia (AML): Biologic and Therapeutic Implications. Blood. 114: 938-938. DOI: 10.1182/Blood.V114.22.938.938  0.372
2009 Lin L, Hutzen B, Peng Z, Lin H, Li P, Li C, Wicha M, Lin J. Abstract A54: STAT3 as a novel therapeutic target in human breast cancer stem cells Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-A54  0.355
2008 Kumari V, Li C. Comparative docking assessment of glucokinase interactions with its allosteric activators. Current Chemical Genomics. 2: 76-89. PMID 20161845 DOI: 10.2174/1875397300802010076  0.312
2008 Bhasin D, Cisek K, Pandharkar T, Regan N, Li C, Pandit B, Lin J, Li PK. Design, synthesis, and studies of small molecule STAT3 inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 391-5. PMID 18006313 DOI: 10.1016/J.Bmcl.2007.10.031  0.395
2007 George TG, Endeshaw MM, Morgan RE, Mahasenan KV, Delfín DA, Mukherjee MS, Yakovich AJ, Fotie J, Li C, Werbovetz KA. Synthesis, biological evaluation, and molecular modeling of 3,5-substituted-N1-phenyl-N4,N4-di-n-butylsulfanilamides as antikinetoplastid antimicrotubule agents. Bioorganic & Medicinal Chemistry. 15: 6071-9. PMID 17618122 DOI: 10.1016/J.Bmc.2007.06.042  0.676
2007 Xu L, Chong Y, Hwang I, D'Onofrio A, Amore K, Beardsley GP, Li C, Olson AJ, Boger DL, Wilson IA. Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase. The Journal of Biological Chemistry. 282: 13033-46. PMID 17324932 DOI: 10.1074/Jbc.M607293200  0.387
2006 Pandit B, Sun Y, Chen P, Sackett DL, Hu Z, Rich W, Li C, Lewis A, Schaefer K, Li PK. Structure-activity-relationship studies of conformationally restricted analogs of combretastatin A-4 derived from SU5416. Bioorganic & Medicinal Chemistry. 14: 6492-501. PMID 16860559 DOI: 10.1016/J.Bmc.2006.06.017  0.404
2006 Li PK, Pandit B, Sackett DL, Hu Z, Zink J, Zhi J, Freeman D, Robey RW, Werbovetz K, Lewis A, Li C. A thalidomide analogue with in vitro antiproliferative, antimitotic, and microtubule-stabilizing activities Molecular Cancer Therapeutics. 5: 450-456. PMID 16505120 DOI: 10.1158/1535-7163.Mct-05-0254  0.37
2006 Fang L, Zhang G, Li C, Zheng X, Zhu L, Xiao JJ, Szakacs G, Nadas J, Chan KK, Wang PG, Sun D. Discovery of a daunorubicin analogue that exhibits potent antitumor activity and overcomes P-gp-mediated drug resistance. Journal of Medicinal Chemistry. 49: 932-41. PMID 16451059 DOI: 10.1021/Jm050800Q  0.312
2005 Briknarová K, Nasertorabi F, Havert ML, Eggleston E, Hoyt DW, Li C, Olson AJ, Vuori K, Ely KR. The serine-rich domain from Crk-associated substrate (p130cas) is a four-helix bundle. The Journal of Biological Chemistry. 280: 21908-14. PMID 15795225 DOI: 10.1074/Jbc.M501258200  0.31
2003 Bennett EM, Li C, Allan PW, Parker WB, Ealick SE. Structural basis for substrate specificity of Escherichia coli purine nucleoside phosphorylase. The Journal of Biological Chemistry. 278: 47110-8. PMID 12937174 DOI: 10.1074/Jbc.M304622200  0.626
1999 Mueller EJ, Oh S, Kavalerchik E, Kappock TJ, Meyer E, Li C, Ealick SE, Stubbe J. Investigation of the ATP binding site of Escherichia coli aminoimidazole ribonucleotide synthetase using affinity labeling and site-directed mutagenesis. Biochemistry. 38: 9831-9. PMID 10433689 DOI: 10.1021/bi990638r  0.452
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