| Year |
Citation |
Score |
| 2024 |
Beetham CM, Schuster CF, Kviatkovski I, Santiago M, Walker S, Gründling A. Histidine transport is essential for the growth of Staphylococcus aureus at low pH. Plos Pathogens. 20: e1011927. PMID 38227607 DOI: 10.1371/journal.ppat.1011927 |
0.606 |
|
| 2023 |
Schultz BJ, Snow ED, Walker S. Mechanism of D-alanine transfer to teichoic acids shows how bacteria acylate cell envelope polymers. Nature Microbiology. PMID 37308592 DOI: 10.1038/s41564-023-01411-0 |
0.324 |
|
| 2023 |
Shlosman I, Fivenson EM, Gilman MSA, Sisley TA, Walker S, Bernhardt TG, Kruse AC, Loparo JJ. Allosteric activation of cell wall synthesis during bacterial growth. Nature Communications. 14: 3439. PMID 37301887 DOI: 10.1038/s41467-023-39037-9 |
0.311 |
|
| 2023 |
Park Y, Taguchi A, Baidin V, Kahne D, Walker S. A Time-Resolved FRET Assay Identifies a Small Molecule that Inhibits the Essential Bacterial Cell Wall Polymerase FtsW. Angewandte Chemie (International Ed. in English). e202301522. PMID 37099323 DOI: 10.1002/anie.202301522 |
0.719 |
|
| 2023 |
Hummels KR, Berry SP, Li Z, Taguchi A, Min JK, Walker S, Marks DS, Bernhardt TG. Coordination of bacterial cell wall and outer membrane biosynthesis. Nature. PMID 36859542 DOI: 10.1038/s41586-023-05750-0 |
0.324 |
|
| 2022 |
Muscato JD, Morris HG, Mychack A, Rajagopal M, Baidin V, Hesser AR, Lee W, İnecik K, Wilson LJ, Kraml CM, Meredith TC, Walker S. Rapid Inhibitor Discovery by Exploiting Synthetic Lethality. Journal of the American Chemical Society. PMID 35170959 DOI: 10.1021/jacs.1c12697 |
0.658 |
|
| 2021 |
Taguchi A, Page JE, Tsui HT, Winkler ME, Walker S. Biochemical reconstitution defines new functions for membrane-bound glycosidases in assembly of the bacterial cell wall. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34475211 DOI: 10.1073/pnas.2103740118 |
0.337 |
|
| 2021 |
Joiner CM, Hammel FA, Janetzko J, Walker S. Protein Substrates Engage the Lumen of O-GlcNAc Transferase's Tetratricopeptide Repeat Domain in Different Ways. Biochemistry. PMID 33709700 DOI: 10.1021/acs.biochem.0c00981 |
0.802 |
|
| 2021 |
Levine ZG, Potter SC, Joiner CM, Fei GQ, Nabet B, Sonnett M, Zachara NE, Gray NS, Paulo JA, Walker S. Mammalian cell proliferation requires noncatalytic functions of O-GlcNAc transferase. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33419956 DOI: 10.1073/pnas.2016778118 |
0.799 |
|
| 2020 |
Schaefer K, Owens TW, Page JE, Santiago M, Kahne D, Walker S. Structure and reconstitution of a hydrolase complex that may release peptidoglycan from the membrane after polymerization. Nature Microbiology. PMID 33168989 DOI: 10.1038/s41564-020-00808-5 |
0.772 |
|
| 2020 |
Itkonen HM, Poulose N, Steele RE, Martin SES, Levine ZG, Duveau DY, Carelli R, Singh R, Urbanucci A, Loda M, Thomas CJ, Mills IG, Walker S. Inhibition of O-GlcNAc transferase renders prostate cancer cells dependent on CDK9. Molecular Cancer Research : McR. PMID 32611550 DOI: 10.1158/1541-7786.Mcr-20-0339 |
0.789 |
|
| 2020 |
Hesser AR, Matano LM, Vickery CR, Wood BM, Santiago AG, Morris HG, Do T, Losick R, Walker S. The length of lipoteichoic acid polymers controls cell size and envelope integrity. Journal of Bacteriology. PMID 32482719 DOI: 10.1128/Jb.00149-20 |
0.806 |
|
| 2020 |
Tan ZW, Fei G, Paulo JA, Bellaousov S, Martin SES, Duveau DY, Thomas CJ, Gygi SP, Boutz PL, Walker S. O-GlcNAc regulates gene expression by controlling detained intron splicing. Nucleic Acids Research. PMID 32329777 DOI: 10.1093/Nar/Gkaa263 |
0.304 |
|
| 2020 |
Laut CL, Perry WJ, Metzger AL, Weiss A, Stauff DL, Walker S, Caprioli RM, Skaar EP. Bacillus anthracis Responds to Targocil-Induced Envelope Damage through EdsRS Activation of Cardiolipin Synthesis. Mbio. 11. PMID 32234818 DOI: 10.1128/Mbio.03375-19 |
0.367 |
|
| 2020 |
Sjodt M, Rohs PDA, Gilman MSA, Erlandson SC, Zheng S, Green AG, Brock KP, Taguchi A, Kahne D, Walker S, Marks DS, Rudner DZ, Bernhardt TG, Kruse AC. Structural coordination of polymerization and crosslinking by a SEDS-bPBP peptidoglycan synthase complex. Nature Microbiology. PMID 32152588 DOI: 10.1038/S41564-020-0687-Z |
0.701 |
|
| 2020 |
Rubino FA, Mollo A, Kumar S, Butler EK, Ruiz N, Walker S, Kahne DE. Detection of transport intermediates in the peptidoglycan flippase MurJ identifies residues essential for conformational cycling. Journal of the American Chemical Society. PMID 32129990 DOI: 10.1021/Jacs.9B12185 |
0.694 |
|
| 2020 |
Do T, Page JE, Walker S. Uncovering the activities, biological roles, and regulation of bacterial cell wall hydrolases and tailoring enzymes. The Journal of Biological Chemistry. PMID 31974163 DOI: 10.1074/Jbc.Rev119.010155 |
0.46 |
|
| 2020 |
Do T, Schaefer K, Santiago AG, Coe KA, Fernandes PB, Kahne D, Pinho MG, Walker S. Staphylococcus aureus cell growth and division are regulated by an amidase that trims peptides from uncrosslinked peptidoglycan. Nature Microbiology. PMID 31932712 DOI: 10.1038/S41564-019-0632-1 |
0.808 |
|
| 2019 |
Schuster CF, Wiedemann DM, Kirsebom FCM, Santiago M, Walker S, Gründling A. High-throughput transposon sequencing highlights the cell wall as an important barrier for osmotic stress in methicillin resistant Staphylococcus aureus and underlines a tailored response to different osmotic stressors. Molecular Microbiology. PMID 31770461 DOI: 10.1111/Mmi.14433 |
0.646 |
|
| 2019 |
Coe KA, Lee W, Stone MC, Komazin-Meredith G, Meredith TC, Grad YH, Walker S. Multi-strain Tn-Seq reveals common daptomycin resistance determinants in Staphylococcus aureus. Plos Pathogens. 15: e1007862. PMID 31738809 DOI: 10.1371/Journal.Ppat.1007862 |
0.357 |
|
| 2019 |
Taguchi A, Kahne D, Walker S. Chemical tools to characterize peptidoglycan synthases. Current Opinion in Chemical Biology. 53: 44-50. PMID 31466035 DOI: 10.1016/J.Cbpa.2019.07.009 |
0.728 |
|
| 2019 |
Welsh MA, Schaefer K, Taguchi A, Kahne D, Walker S. The direction of chain growth and substrate preferences of SEDS-family peptidoglycan glycosyltransferases. Journal of the American Chemical Society. PMID 31386359 DOI: 10.1021/Jacs.9B06358 |
0.736 |
|
| 2019 |
Joiner CM, Levine ZG, Aonbangkhen C, Woo CM, Walker S. Aspartate residues far from the active site drive O-GlcNAc transferase substrate selection. Journal of the American Chemical Society. PMID 31373491 DOI: 10.1021/Jacs.9B06061 |
0.801 |
|
| 2019 |
Lane EA, Choi DW, Garcia-Haro L, Levine ZG, Tedoldi M, Walker S, Danial NN. HCF-1 Regulates De Novo Lipogenesis through a Nutrient-Sensitive Complex with ChREBP. Molecular Cell. PMID 31227231 DOI: 10.1016/J.Molcel.2019.05.019 |
0.787 |
|
| 2019 |
Itkonen HM, Poulose N, Walker S, Mills IG. CDK9 Inhibition Induces a Metabolic Switch that Renders Prostate Cancer Cells Dependent on Fatty Acid Oxidation. Neoplasia (New York, N.Y.). 21: 713-720. PMID 31151054 DOI: 10.1016/J.Neo.2019.05.001 |
0.326 |
|
| 2019 |
Itkonen HM, Urbanucci A, Martin SE, Khan A, Mathelier A, Thiede B, Walker S, Mills IG. High OGT activity is essential for MYC-driven proliferation of prostate cancer cells. Theranostics. 9: 2183-2197. PMID 31149037 DOI: 10.7150/Thno.30834 |
0.314 |
|
| 2019 |
Joiner CM, Li H, Jiang J, Walker S. Structural characterization of the O-GlcNAc cycling enzymes: insights into substrate recognition and catalytic mechanisms. Current Opinion in Structural Biology. 56: 97-106. PMID 30708324 DOI: 10.1016/J.Sbi.2018.12.003 |
0.803 |
|
| 2019 |
Taguchi A, Welsh MA, Marmont LS, Lee W, Sjodt M, Kruse AC, Kahne D, Bernhardt TG, Walker S. FtsW is a peptidoglycan polymerase that is functional only in complex with its cognate penicillin-binding protein. Nature Microbiology. PMID 30692671 DOI: 10.1038/S41564-018-0345-X |
0.733 |
|
| 2018 |
Sehin Y, Koshla O, Dacyuk Y, Zhao R, Ross R, Myronovskyi M, Limbach PA, Luzhetskyy A, Walker S, Fedorenko V, Ostash B. Gene ssfg_01967 (miaB) for tRNA modification influences morphogenesis and moenomycin biosynthesis in Streptomyces ghanaensis ATCC14672. Microbiology (Reading, England). PMID 30543507 DOI: 10.1099/Mic.0.000747 |
0.348 |
|
| 2018 |
Rohs PDA, Buss J, Sim SI, Squyres GR, Srisuknimit V, Smith M, Cho H, Sjodt M, Kruse AC, Garner EC, Walker S, Kahne DE, Bernhardt TG. A central role for PBP2 in the activation of peptidoglycan polymerization by the bacterial cell elongation machinery. Plos Genetics. 14: e1007726. PMID 30335755 DOI: 10.1371/Journal.Pgen.1007726 |
0.722 |
|
| 2018 |
Baranowski C, Welsh MA, Sham LT, Eskandarian HA, Lim HC, Kieser KJ, Wagner JC, McKinney J, Fantner GE, Ioerger TR, Walker S, Bernhardt TG, Rubin EJ, Rego EH. Maturing peptidoglycan requires non-canonical crosslinks to maintain shape. Elife. 7. PMID 30324906 DOI: 10.7554/Elife.37516 |
0.376 |
|
| 2018 |
Buss JA, Baidin V, Welsh MA, Flores-Kim J, Cho H, Wood BM, Uehara T, Walker S, Kahne D, Bernhardt TG. A pathway-directed screen for inhibitors of the bacterial cell elongation machinery. Antimicrobial Agents and Chemotherapy. PMID 30323039 DOI: 10.1128/Aac.01530-18 |
0.727 |
|
| 2018 |
Martin SES, Tan ZW, Itkonen HM, Duveau DY, Paulo JA, Janetzko J, Boutz PL, Törk L, Moss FA, Thomas CJ, Gygi SP, Lazarus MB, Walker S. Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors. Journal of the American Chemical Society. PMID 30285435 DOI: 10.1021/Jacs.8B07328 |
0.807 |
|
| 2018 |
Wood BM, Santa-Maria JP, Matano LM, Vickery CR, Walker S. A partial reconstitution implicates DltD in catalyzing lipoteichoic acid D-alanylation. The Journal of Biological Chemistry. PMID 30237166 DOI: 10.1074/Jbc.Ra118.004561 |
0.791 |
|
| 2018 |
Tiwari KB, Gatto C, Walker S, Wilkinson BJ. Targocil-exposure of Blocks Translocation of the Major Autolysin Atl Across the Membrane Resulting in a Significant Decrease in Autolysis. Antimicrobial Agents and Chemotherapy. PMID 29735561 DOI: 10.1128/Aac.00323-18 |
0.4 |
|
| 2018 |
Santiago M, Lee W, Fayad AA, Coe KA, Rajagopal M, Do T, Hennessen F, Srisuknimit V, Müller R, Meredith TC, Walker S. Genome-wide mutant profiling predicts the mechanism of a Lipid II binding antibiotic. Nature Chemical Biology. PMID 29662210 DOI: 10.1038/S41589-018-0041-4 |
0.785 |
|
| 2018 |
Sjodt M, Brock K, Dobihal G, Rohs PDA, Green AG, Hopf TA, Meeske AJ, Srisuknimit V, Kahne D, Walker S, Marks DS, Bernhardt TG, Rudner DZ, Kruse AC. Structure of the peptidoglycan polymerase RodA resolved by evolutionary coupling analysis. Nature. PMID 29590088 DOI: 10.1038/Nature25985 |
0.723 |
|
| 2018 |
Rubino FA, Kumar S, Ruiz N, Walker S, Kahne D. Membrane potential is required for MurJ function. Journal of the American Chemical Society. PMID 29558128 DOI: 10.1021/Jacs.8B00942 |
0.723 |
|
| 2018 |
Lee W, Do T, Zhang G, Kahne D, Meredith TC, Walker S. Antibiotic combinations that enable one-step, targeted mutagenesis of chromosomal genes. Acs Infectious Diseases. PMID 29534563 DOI: 10.1021/Acsinfecdis.8B00017 |
0.711 |
|
| 2018 |
Levine Z, Fan C, Melicher MS, Orman M, Benjamin T, Walker S. O-GlcNAc transferase recognizes protein substrates using an asparagine ladder in the TPR superhelix. Journal of the American Chemical Society. PMID 29485866 DOI: 10.1021/Jacs.7B13546 |
0.808 |
|
| 2018 |
Schaefer K, Owens TW, Kahne D, Walker S. Substrate preferences establish the order of cell wall assembly in Staphylococcus aureus. Journal of the American Chemical Society. PMID 29402087 DOI: 10.1021/Jacs.7B13551 |
0.729 |
|
| 2018 |
Vickery CR, Wood BM, Morris HG, Losick R, Walker S. Reconstitution of S. aureus lipoteichoic acid synthase activity identifies Congo red as a selective inhibitor. Journal of the American Chemical Society. PMID 29300473 DOI: 10.1021/Jacs.7B11704 |
0.814 |
|
| 2018 |
Sjodt M, Brock K, Dobihal G, Rohs PDA, Green AG, Hopf TA, Meeske AJ, Srisuknimit V, Kahne D, Walker S, Marks DS, Bernhardt TG, Rudner DZ, Kruse AC. Structure and function of the SEDS:bPBP bacterial cell wall synthesis machinery Acta Crystallographica Section a Foundations and Advances. 74: a144-a144. DOI: 10.1107/S0108767318098550 |
0.701 |
|
| 2017 |
Welsh MA, Taguchi A, Schaefer K, Van Tyne D, Lebreton F, Gilmore MS, Kahne D, Walker S. Identification of a Functionally Unique Family of Penicillin-Binding Proteins. Journal of the American Chemical Society. PMID 29182854 DOI: 10.1021/Jacs.7B10170 |
0.719 |
|
| 2017 |
Matano LM, Morris HG, Hesser AR, Martin SES, Lee W, Owens TW, Laney E, Nakaminami H, Hooper D, Meredith TC, Walker S. An antibiotic that inhibits the ATPase activity of an ABC transporter by binding to a remote extracellular site. Journal of the American Chemical Society. PMID 28727445 DOI: 10.1021/Jacs.7B04726 |
0.396 |
|
| 2017 |
Srisuknimit V, Qiao Y, Schaefer K, Kahne D, Walker S. Peptidoglycan Cross-Linking Preferences of Staphylococcus aureus Penicillin-Binding Proteins Have Implications for Treating MRSA Infections. Journal of the American Chemical Society. PMID 28691491 DOI: 10.1021/Jacs.7B04881 |
0.72 |
|
| 2017 |
DeFrancesco AS, Masloboeva N, Syed AK, DeLoughery A, Bradshaw N, Li GW, Gilmore MS, Walker S, Losick R. Genome-wide screen for genes involved in eDNA release during biofilm formation by Staphylococcus aureus. Proceedings of the National Academy of Sciences of the United States of America. PMID 28674000 DOI: 10.1073/Pnas.1704544114 |
0.358 |
|
| 2017 |
Qiao Y, Srisuknimit V, Rubino F, Schaefer K, Ruiz N, Walker S, Kahne D. Lipid II overproduction allows direct assay of transpeptidase inhibition by β-lactams. Nature Chemical Biology. PMID 28553948 DOI: 10.1038/Nchembio.2388 |
0.73 |
|
| 2017 |
Lee W, VanderVen BC, Walker S, Russell DG. Novel protein acetyltransferase, Rv2170, modulates carbon and energy metabolism in Mycobacterium tuberculosis. Scientific Reports. 7: 72. PMID 28250431 DOI: 10.1038/S41598-017-00067-1 |
0.338 |
|
| 2017 |
Janetzko J, Walker S. Aspartate glycosylation triggers isomerization to isoaspartate. Journal of the American Chemical Society. PMID 28207246 DOI: 10.1021/Jacs.6B12866 |
0.794 |
|
| 2017 |
Schaefer K, Matano LM, Qiao Y, Kahne D, Walker S. In vitro reconstitution demonstrates the cell wall ligase activity of LCP proteins. Nature Chemical Biology. PMID 28166208 DOI: 10.1038/Nchembio.2302 |
0.724 |
|
| 2016 |
Janetzko J, Trauger SA, Lazarus MB, Walker S. How the glycosyltransferase OGT catalyzes amide bond cleavage. Nature Chemical Biology. PMID 27618188 DOI: 10.1038/Nchembio.2173 |
0.802 |
|
| 2016 |
Matano LM, Morris HG, Wood BM, Meredith TC, Walker S. Accelerating the discovery of antibacterial compounds using pathway-directed whole cell screening. Bioorganic & Medicinal Chemistry. PMID 27594549 DOI: 10.1016/J.Bmc.2016.08.003 |
0.348 |
|
| 2016 |
Rajagopal M, Martin MJ, Santiago M, Lee W, Kos VN, Meredith T, Gilmore MS, Walker S. Multidrug Intrinsic Resistance Factors in Staphylococcus aureus Identified by Profiling Fitness within High-Diversity Transposon Libraries. Mbio. 7. PMID 27531908 DOI: 10.1128/Mbio.00950-16 |
0.786 |
|
| 2016 |
Meeske AJ, Riley EP, Robins WP, Uehara T, Mekalanos JJ, Kahne D, Walker S, Kruse AC, Bernhardt TG, Rudner DZ. SEDS proteins are a widespread family of bacterial cell wall polymerases. Nature. PMID 27525505 DOI: 10.1038/Nature19331 |
0.716 |
|
| 2016 |
Levine ZG, Walker S. The Biochemistry of O-GlcNAc Transferase: Which Functions Make It Essential in Mammalian Cells? Annual Review of Biochemistry. 85: 631-657. PMID 27294441 DOI: 10.1146/Annurev-Biochem-060713-035344 |
0.807 |
|
| 2016 |
Markovski M, Bohrhunter JL, Lupoli TJ, Uehara T, Walker S, Kahne DE, Bernhardt TG. Cofactor bypass variants reveal a conformational control mechanism governing cell wall polymerase activity. Proceedings of the National Academy of Sciences of the United States of America. PMID 27071112 DOI: 10.1073/Pnas.1524538113 |
0.722 |
|
| 2016 |
Rajagopal M, Walker S. Envelope Structures of Gram-Positive Bacteria. Current Topics in Microbiology and Immunology. PMID 26919863 DOI: 10.1007/82_2015_5021 |
0.705 |
|
| 2016 |
Goodreid JD, Janetzko J, Santa Maria JP, Wong KS, Leung E, Eger BT, Bryson S, Pai EF, Gray-Owen SD, Walker S, Houry WA, Batey RA. Development and Characterization of Potent Cyclic Acyldepsipeptide Analogues with Increased Antimicrobial Activity. Journal of Medicinal Chemistry. 59: 624-46. PMID 26818454 DOI: 10.1021/Acs.Jmedchem.5B01451 |
0.802 |
|
| 2015 |
Lee W, Schaefer K, Qiao Y, Srisuknimit V, Steinmetz H, Müller R, Kahne D, Walker S. The mechanism of action of lysobactin. Journal of the American Chemical Society. PMID 26683668 DOI: 10.1021/Jacs.5B11807 |
0.728 |
|
| 2015 |
Pasquina L, Santa Maria JP, McKay Wood B, Moussa SH, Matano LM, Santiago M, Martin SE, Lee W, Meredith TC, Walker S. A synthetic lethal approach for compound and target identification in Staphylococcus aureus. Nature Chemical Biology. PMID 26619249 DOI: 10.1038/Nchembio.1967 |
0.814 |
|
| 2015 |
Tsypik O, Yushchuk O, Zaburannyi N, Flärdh K, Walker S, Fedorenko V, Ostash B. Transcriptional regulators of GntR family in Streptomyces coelicolor A3(2): analysis in silico and in vivo of YtrA subfamily. Folia Microbiologica. PMID 26433722 DOI: 10.1007/S12223-015-0426-7 |
0.308 |
|
| 2015 |
Angelova M, Ortiz-Meoz RF, Walker S, Knipe DM. Inhibition of O-Linked N-Acetylglucosamine Transferase Reduces Replication of Herpes Simplex Virus and Human Cytomegalovirus. Journal of Virology. 89: 8474-83. PMID 26041297 DOI: 10.1128/Jvi.01002-15 |
0.355 |
|
| 2015 |
Santiago M, Matano LM, Moussa SH, Gilmore MS, Walker S, Meredith TC. A new platform for ultra-high density Staphylococcus aureus transposon libraries. Bmc Genomics. 16: 252. PMID 25888466 DOI: 10.1186/S12864-015-1361-3 |
0.633 |
|
| 2015 |
Ortiz-Meoz RF, Jiang J, Lazarus MB, Orman M, Janetzko J, Fan C, Duveau DY, Tan ZW, Thomas CJ, Walker S. A small molecule that inhibits OGT activity in cells. Acs Chemical Biology. 10: 1392-7. PMID 25751766 DOI: 10.1021/Acschembio.5B00004 |
0.808 |
|
| 2015 |
Schirner K, Eun YJ, Dion M, Luo Y, Helmann JD, Garner EC, Walker S. Lipid-linked cell wall precursors regulate membrane association of bacterial actin MreB. Nature Chemical Biology. 11: 38-45. PMID 25402772 DOI: 10.1038/Nchembio.1689 |
0.382 |
|
| 2015 |
Lopatniuk M, Ostash B, Makitrynskyy R, Walker S, Luzhetskyy A, Fedorenko V. Testing the utility of site-specific recombinases for manipulations of genome of moenomycin producer Streptomyces ghanaensis ATCC14672 Journal of Applied Genetics. DOI: 10.1007/S13353-015-0283-8 |
0.323 |
|
| 2014 |
Mutenko H, Makitrinskyy R, Tsypik O, Walker S, Ostash B, Fedorenko V. Genes for biosynthesis of butenolide-like signalling molecules in Streptomyces ghanaensis, their role in moenomycin production Genetika. 50: 645-651. PMID 25715454 DOI: 10.1134/S1022795414060076 |
0.313 |
|
| 2014 |
Janetzko J, Walker S. The making of a sweet modification: structure and function of O-GlcNAc transferase. The Journal of Biological Chemistry. 289: 34424-32. PMID 25336649 DOI: 10.1074/Jbc.R114.604405 |
0.794 |
|
| 2014 |
Qiao Y, Lebar MD, Schirner K, Schaefer K, Tsukamoto H, Kahne D, Walker S. Detection of lipid-linked peptidoglycan precursors by exploiting an unexpected transpeptidase reaction. Journal of the American Chemical Society. 136: 14678-81. PMID 25291014 DOI: 10.1021/Ja508147S |
0.721 |
|
| 2014 |
Valentino MD, Foulston L, Sadaka A, Kos VN, Villet RA, Santa Maria J, Lazinski DW, Camilli A, Walker S, Hooper DC, Gilmore MS. Genes contributing to Staphylococcus aureus fitness in abscess- and infection-related ecologies. Mbio. 5: e01729-14. PMID 25182329 DOI: 10.1128/Mbio.01729-14 |
0.791 |
|
| 2014 |
Santa Maria JP, Sadaka A, Moussa SH, Brown S, Zhang YJ, Rubin EJ, Gilmore MS, Walker S. Compound-gene interaction mapping reveals distinct roles for Staphylococcus aureus teichoic acids. Proceedings of the National Academy of Sciences of the United States of America. 111: 12510-5. PMID 25104751 DOI: 10.1073/Pnas.1404099111 |
0.813 |
|
| 2014 |
Lebar MD, May JM, Meeske AJ, Leiman SA, Lupoli TJ, Tsukamoto H, Losick R, Rudner DZ, Walker S, Kahne D. Reconstitution of peptidoglycan cross-linking leads to improved fluorescent probes of cell wall synthesis. Journal of the American Chemical Society. 136: 10874-7. PMID 25036369 DOI: 10.1021/Ja505668F |
0.712 |
|
| 2014 |
Sherman DJ, Lazarus MB, Murphy L, Liu C, Walker S, Ruiz N, Kahne D. Decoupling catalytic activity from biological function of the ATPase that powers lipopolysaccharide transport. Proceedings of the National Academy of Sciences of the United States of America. 111: 4982-7. PMID 24639492 DOI: 10.1073/Pnas.1323516111 |
0.685 |
|
| 2014 |
Ortiz-Meoz RF, Merbl Y, Kirschner MW, Walker S. Microarray discovery of new OGT substrates: the medulloblastoma oncogene OTX2 is O-GlcNAcylated. Journal of the American Chemical Society. 136: 4845-8. PMID 24580054 DOI: 10.1021/Ja500451W |
0.381 |
|
| 2014 |
Lupoli TJ, Lebar MD, Markovski M, Bernhardt T, Kahne D, Walker S. Lipoprotein activators stimulate escherichia coli penicillin-binding proteins by different mechanisms Journal of the American Chemical Society. 136: 52-55. PMID 24341982 DOI: 10.1021/Ja410813J |
0.709 |
|
| 2014 |
Rebets Y, Lupoli T, Qiao Y, Schirner K, Villet R, Hooper D, Kahne D, Walker S. Moenomycin resistance mutations in Staphylococcus aureus reduce peptidoglycan chain length and cause aberrant cell division. Acs Chemical Biology. 9: 459-67. PMID 24255971 DOI: 10.1021/Cb4006744 |
0.707 |
|
| 2014 |
Garg N, Oman TJ, Andrew Wang TS, De Gonzalo CVG, Walker S, Van Der Donk WA. Mode of action and structure-activity relationship studies of geobacillin i Journal of Antibiotics. 67: 133-136. PMID 24169799 DOI: 10.1038/Ja.2013.112 |
0.41 |
|
| 2014 |
Qiao Y, Lebar MD, Schirner K, Schaefer K, Tsukamoto H, Kahne D, Walker S. Detection of lipid-linked peptidoglycan precursors by exploiting an unexpected transpeptidase reaction Journal of the American Chemical Society. 136: 14678-14681. DOI: 10.1021/ja508147s |
0.615 |
|
| 2014 |
Lebar MD, May JM, Meeske AJ, Leiman SA, Lupoli TJ, Tsukamoto H, Losick R, Rudner DZ, Walker S, Kahne D. Reconstitution of peptidoglycan cross-linking leads to improved fluorescent probes of cell wall synthesis Journal of the American Chemical Society. 136: 10874-10877. DOI: 10.1021/ja505668f |
0.64 |
|
| 2013 |
Lazarus MB, Jiang J, Kapuria V, Bhuiyan T, Janetzko J, Zandberg WF, Vocadlo DJ, Herr W, Walker S. HCF-1 is cleaved in the active site of O-GlcNAc transferase. Science (New York, N.Y.). 342: 1235-9. PMID 24311690 DOI: 10.1126/Science.1243990 |
0.79 |
|
| 2013 |
Ostash B, Campbell J, Luzhetskyy A, Walker S. MoeH5: a natural glycorandomizer from the moenomycin biosynthetic pathway. Molecular Microbiology. 90: 1324-38. PMID 24164498 DOI: 10.1111/Mmi.12437 |
0.597 |
|
| 2013 |
Makitrynskyy R, Ostash B, Tsypik O, Rebets Y, Doud E, Meredith T, Luzhetskyy A, Bechthold A, Walker S, Fedorenko V. Pleiotropic regulatory genes bldA, adpA and absB are implicated in production of phosphoglycolipid antibiotic moenomycin. Open Biology. 3: 130121. PMID 24153004 DOI: 10.1098/Rsob.130121 |
0.303 |
|
| 2013 |
Brown S, Santa Maria JP, Walker S. Wall teichoic acids of gram-positive bacteria. Annual Review of Microbiology. 67: 313-36. PMID 24024634 DOI: 10.1146/Annurev-Micro-092412-155620 |
0.813 |
|
| 2013 |
Pasquina LW, Santa Maria JP, Walker S. Teichoic acid biosynthesis as an antibiotic target. Current Opinion in Microbiology. 16: 531-7. PMID 23916223 DOI: 10.1016/J.Mib.2013.06.014 |
0.817 |
|
| 2013 |
Lebar MD, Lupoli TJ, Tsukamoto H, May JM, Walker S, Kahne D. Forming cross-linked peptidoglycan from synthetic gram-negative lipid II Journal of the American Chemical Society. 135: 4632-4635. PMID 23480167 DOI: 10.1021/Ja312510M |
0.721 |
|
| 2013 |
Gampe CM, Tsukamoto H, Doud EH, Walker S, Kahne D. Tuning the moenomycin pharmacophore to enable discovery of bacterial cell wall synthesis inhibitors. Journal of the American Chemical Society. 135: 3776-9. PMID 23448584 DOI: 10.1021/Ja4000933 |
0.734 |
|
| 2013 |
Wang H, Gill CJ, Lee SH, Mann P, Zuck P, Meredith TC, Murgolo N, She X, Kales S, Liang L, Liu J, Wu J, Santa Maria J, Su J, Pan J, ... ... Walker S, et al. Discovery of wall teichoic acid inhibitors as potential anti-MRSA β-lactam combination agents. Chemistry & Biology. 20: 272-84. PMID 23438756 DOI: 10.1016/J.Chembiol.2012.11.013 |
0.803 |
|
| 2012 |
Lazarus MB, Jiang J, Gloster TM, Zandberg WF, Whitworth GE, Vocadlo DJ, Walker S. Structural snapshots of the reaction coordinate for O-GlcNAc transferase. Nature Chemical Biology. 8: 966-8. PMID 23103939 DOI: 10.1038/Nchembio.1109 |
0.363 |
|
| 2012 |
Brown S, Xia G, Luhachack LG, Campbell J, Meredith TC, Chen C, Winstel V, Gekeler C, Irazoqui JE, Peschel A, Walker S. Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids. Proceedings of the National Academy of Sciences of the United States of America. 109: 18909-14. PMID 23027967 DOI: 10.1073/Pnas.1209126109 |
0.677 |
|
| 2012 |
Knerr PJ, Oman TJ, Garcia De Gonzalo CV, Lupoli TJ, Walker S, Van Der Donk WA. Non-proteinogenic amino acids in lacticin 481 analogues result in more potent inhibition of peptidoglycan transglycosylation Acs Chemical Biology. 7: 1791-1795. PMID 22920239 DOI: 10.1021/Cb300372B |
0.407 |
|
| 2012 |
Suzuki T, Campbell J, Kim Y, Swoboda JG, Mylonakis E, Walker S, Gilmore MS. Wall teichoic acid protects Staphylococcus aureus from inhibition by Congo red and other dyes. The Journal of Antimicrobial Chemotherapy. 67: 2143-51. PMID 22615298 DOI: 10.1093/Jac/Dks184 |
0.808 |
|
| 2012 |
Campbell J, Singh AK, Swoboda JG, Gilmore MS, Wilkinson BJ, Walker S. An antibiotic that inhibits a late step in wall teichoic acid biosynthesis induces the cell wall stress stimulon in Staphylococcus aureus. Antimicrobial Agents and Chemotherapy. 56: 1810-20. PMID 22290958 DOI: 10.1128/Aac.05938-11 |
0.817 |
|
| 2012 |
Jiang J, Lazarus MB, Pasquina L, Sliz P, Walker S. A neutral diphosphate mimic crosslinks the active site of human O-GlcNAc transferase. Nature Chemical Biology. 8: 72-7. PMID 22082911 DOI: 10.1038/Nchembio.711 |
0.428 |
|
| 2011 |
Gampe CM, Tsukamoto H, Wang TS, Walker S, Kahne D. Modular synthesis of diphospholipid oligosaccharide fragments of the bacterial cell wall and their use to study the mechanism of moenomycin and other antibiotics. Tetrahedron. 67: 9771-9778. PMID 22505780 DOI: 10.1016/J.Tet.2011.09.114 |
0.754 |
|
| 2011 |
Oman TJ, Lupoli TJ, Wang TSA, Kahne D, Walker S, Van Der Donk WA. Haloduracin α binds the peptidoglycan precursor lipid II with 2:1 stoichiometry Journal of the American Chemical Society. 133: 17544-17547. PMID 22003874 DOI: 10.1021/Ja206281K |
0.705 |
|
| 2011 |
Rabyk M, Ostash B, Rebets Y, Walker S, Fedorenko V. Streptomyces ghanaensis pleiotropic regulatory gene wblA(gh) influences morphogenesis and moenomycin production. Biotechnology Letters. 33: 2481-6. PMID 21858667 DOI: 10.1007/S10529-011-0728-Z |
0.306 |
|
| 2011 |
Lupoli TJ, Tsukamoto H, Doud EH, Wang TS, Walker S, Kahne D. Transpeptidase-mediated incorporation of D-amino acids into bacterial peptidoglycan. Journal of the American Chemical Society. 133: 10748-51. PMID 21682301 DOI: 10.1021/Ja2040656 |
0.738 |
|
| 2011 |
Wang TS, Lupoli TJ, Sumida Y, Tsukamoto H, Wu Y, Rebets Y, Kahne DE, Walker S. Primer preactivation of peptidoglycan polymerases. Journal of the American Chemical Society. 133: 8528-30. PMID 21568328 DOI: 10.1021/Ja2028712 |
0.735 |
|
| 2011 |
Suzuki T, Campbell J, Swoboda JG, Walker S, Gilmore MS. Role of wall teichoic acids in Staphylococcus aureus endophthalmitis. Investigative Ophthalmology & Visual Science. 52: 3187-92. PMID 21345983 DOI: 10.1167/Iovs.10-6558 |
0.815 |
|
| 2011 |
Ostash B, Rebets Y, Myronovskyy M, Tsypik O, Ostash I, Kulachkovskyy O, Datsyuk Y, Nakamura T, Walker S, Fedorenko V. Identification and characterization of the Streptomyces globisporus 1912 regulatory gene lndYR that affects sporulation and antibiotic production. Microbiology (Reading, England). 157: 1240-9. PMID 21292750 DOI: 10.1099/Mic.0.045088-0 |
0.305 |
|
| 2011 |
Schirner K, Stone LK, Walker S. ABC transporters required for export of wall teichoic acids do not discriminate between different main chain polymers. Acs Chemical Biology. 6: 407-12. PMID 21280653 DOI: 10.1021/Cb100390W |
0.387 |
|
| 2011 |
Lazarus MB, Nam Y, Jiang J, Sliz P, Walker S. Structure of human O-GlcNAc transferase and its complex with a peptide substrate. Nature. 469: 564-7. PMID 21240259 DOI: 10.1038/Nature09638 |
0.397 |
|
| 2011 |
Doud EH, Perlstein DL, Wolpert M, Cane DE, Walker S. Two distinct mechanisms for TIM barrel prenyltransferases in bacteria. Journal of the American Chemical Society. 133: 1270-3. PMID 21214173 DOI: 10.1021/Ja109578B |
0.744 |
|
| 2011 |
Suzuki T, Swoboda JG, Campbell J, Walker S, Gilmore MS. In vitro antimicrobial activity of wall teichoic acid biosynthesis inhibitors against Staphylococcus aureus isolates. Antimicrobial Agents and Chemotherapy. 55: 767-74. PMID 21098254 DOI: 10.1128/Aac.00879-10 |
0.805 |
|
| 2011 |
Campbell J, Singh AK, Santa Maria JP, Kim Y, Brown S, Swoboda JG, Mylonakis E, Wilkinson BJ, Walker S. Synthetic lethal compound combinations reveal a fundamental connection between wall teichoic acid and peptidoglycan biosyntheses in Staphylococcus aureus. Acs Chemical Biology. 6: 106-16. PMID 20961110 DOI: 10.1021/Cb100269F |
0.813 |
|
| 2010 |
Paradis-Bleau C, Markovski M, Uehara T, Lupoli TJ, Walker S, Kahne DE, Bernhardt TG. Lipoprotein cofactors located in the outer membrane activate bacterial cell wall polymerases. Cell. 143: 1110-20. PMID 21183074 DOI: 10.1016/J.Cell.2010.11.037 |
0.748 |
|
| 2010 |
Brown S, Meredith T, Swoboda J, Walker S. Staphylococcus aureus and Bacillus subtilis W23 make polyribitol wall teichoic acids using different enzymatic pathways. Chemistry & Biology. 17: 1101-10. PMID 21035733 DOI: 10.1016/J.Chembiol.2010.07.017 |
0.815 |
|
| 2010 |
Ostash B, Walker S. Moenomycin family antibiotics: chemical synthesis, biosynthesis, and biological activity. Natural Product Reports. 27: 1594-617. PMID 20730219 DOI: 10.1039/C001461N |
0.378 |
|
| 2010 |
Ostash B, Ostash I, Zhu L, Kharel MK, Luzhetskiǐ A, Bechthold A, Walker S, Rohr J, Fedorenko V. Properties of lanK-based regulatory circuit involved in landomycin biosynthesis in Streptomyces cyanogenus S136 Genetika. 46: 604-609. PMID 20583594 DOI: 10.1134/S1022795410050030 |
0.333 |
|
| 2010 |
Fuse S, Tsukamoto H, Yuan Y, Wang TS, Zhang Y, Bolla M, Walker S, Sliz P, Kahne D. Functional and structural analysis of a key region of the cell wall inhibitor moenomycin. Acs Chemical Biology. 5: 701-11. PMID 20496948 DOI: 10.1021/Cb100048Q |
0.771 |
|
| 2010 |
Silhavy TJ, Kahne D, Walker S. The bacterial cell envelope. Cold Spring Harbor Perspectives in Biology. 2: a000414. PMID 20452953 DOI: 10.1101/Cshperspect.A000414 |
0.701 |
|
| 2010 |
Lee K, Campbell J, Swoboda JG, Cuny GD, Walker S. Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus. Bioorganic & Medicinal Chemistry Letters. 20: 1767-70. PMID 20138521 DOI: 10.1016/J.Bmcl.2010.01.036 |
0.812 |
|
| 2010 |
Perlstein DL, Wang TS, Doud EH, Kahne D, Walker S. The role of the substrate lipid in processive glycan polymerization by the peptidoglycan glycosyltransferases. Journal of the American Chemical Society. 132: 48-9. PMID 20017480 DOI: 10.1021/Ja909325M |
0.799 |
|
| 2010 |
Swoboda JG, Campbell J, Meredith TC, Walker S. Wall teichoic acid function, biosynthesis, and inhibition. Chembiochem : a European Journal of Chemical Biology. 11: 35-45. PMID 19899094 DOI: 10.1002/Cbic.200900557 |
0.813 |
|
| 2009 |
Lupoli TJ, Taniguchi T, Wang TS, Perlstein DL, Walker S, Kahne DE. Studying a cell division amidase using defined peptidoglycan substrates. Journal of the American Chemical Society. 131: 18230-1. PMID 19957935 DOI: 10.1021/Ja908916Z |
0.812 |
|
| 2009 |
Fang X, Nam J, Shin D, Rew Y, Boger DL, Walker S. Functional and biochemical analysis of a key series of ramoplanin analogues. Bioorganic & Medicinal Chemistry Letters. 19: 6189-91. PMID 19783144 DOI: 10.1016/J.Bmcl.2009.09.001 |
0.61 |
|
| 2009 |
Swoboda JG, Meredith TC, Campbell J, Brown S, Suzuki T, Bollenbach T, Malhowski AJ, Kishony R, Gilmore MS, Walker S. Discovery of a small molecule that blocks wall teichoic acid biosynthesis in Staphylococcus aureus. Acs Chemical Biology. 4: 875-83. PMID 19689117 DOI: 10.1021/Cb900151K |
0.824 |
|
| 2009 |
Ostash B, Doud EH, Lin C, Ostash I, Perlstein DL, Fuse S, Wolpert M, Kahne D, Walker S. Complete characterization of the seventeen step moenomycin biosynthetic pathway. Biochemistry. 48: 8830-41. PMID 19640006 DOI: 10.1021/Bi901018Q |
0.816 |
|
| 2009 |
Ostash B, Makitrinskyy R, Walker S, Fedorenko V. Identification and characterization of Streptomyces ghanaensis ATCC14672 integration sites for three actinophage-based plasmids. Plasmid. 61: 171-5. PMID 19167423 DOI: 10.1016/J.Plasmid.2008.12.002 |
0.347 |
|
| 2008 |
Wang TS, Manning SA, Walker S, Kahne D. Isolated peptidoglycan glycosyltransferases from different organisms produce different glycan chain lengths. Journal of the American Chemical Society. 130: 14068-9. PMID 18834124 DOI: 10.1021/Ja806016Y |
0.722 |
|
| 2008 |
Yuan Y, Fuse S, Ostash B, Sliz P, Kahne D, Walker S. Structural analysis of the contacts anchoring moenomycin to peptidoglycan glycosyltransferases and implications for antibiotic design. Acs Chemical Biology. 3: 429-36. PMID 18642800 DOI: 10.1021/Cb800078A |
0.782 |
|
| 2008 |
Ostash I, Ostash B, Luzhetskyy A, Bechthold A, Walker S, Fedorenko V. Coordination of export and glycosylation of landomycins in Streptomyces cyanogenus S136. Fems Microbiology Letters. 285: 195-202. PMID 18537830 DOI: 10.1111/J.1574-6968.2008.01225.X |
0.366 |
|
| 2008 |
Ostash I, Rebets Y, Ostash B, Kobylyanskyy A, Myronovskyy M, Nakamura T, Walker S, Fedorenko V. An ABC transporter encoding gene lndW confers resistance to landomycin E. Archives of Microbiology. 190: 105-9. PMID 18369595 DOI: 10.1007/S00203-008-0367-5 |
0.336 |
|
| 2008 |
Meredith TC, Swoboda JG, Walker S. Late-stage polyribitol phosphate wall teichoic acid biosynthesis in Staphylococcus aureus. Journal of Bacteriology. 190: 3046-56. PMID 18281399 DOI: 10.1128/Jb.01880-07 |
0.796 |
|
| 2008 |
Brown S, Zhang YH, Walker S. A revised pathway proposed for Staphylococcus aureus wall teichoic acid biosynthesis based on in vitro reconstitution of the intracellular steps. Chemistry & Biology. 15: 12-21. PMID 18215769 DOI: 10.1016/J.Chembiol.2007.11.011 |
0.655 |
|
| 2008 |
Gross BJ, Swoboda JG, Walker S. A strategy to discover inhibitors of O-linked glycosylation. Journal of the American Chemical Society. 130: 440-1. PMID 18092786 DOI: 10.1021/Ja078125S |
0.795 |
|
| 2007 |
Perlstein DL, Zhang Y, Wang TS, Kahne DE, Walker S. The direction of glycan chain elongation by peptidoglycan glycosyltransferases. Journal of the American Chemical Society. 129: 12674-5. PMID 17914829 DOI: 10.1021/Ja075965Y |
0.819 |
|
| 2007 |
Barrett D, Wang TS, Yuan Y, Zhang Y, Kahne D, Walker S. Analysis of glycan polymers produced by peptidoglycan glycosyltransferases. The Journal of Biological Chemistry. 282: 31964-71. PMID 17704540 DOI: 10.1074/Jbc.M705440200 |
0.818 |
|
| 2007 |
Leimkuhler C, Fridman M, Lupoli T, Walker S, Walsh CT, Kahne D. Characterization of rhodosaminyl transfer by the AknS/AknT glycosylation complex and its use in reconstituting the biosynthetic pathway of aclacinomycin A. Journal of the American Chemical Society. 129: 10546-50. PMID 17685523 DOI: 10.1021/Ja072909O |
0.661 |
|
| 2007 |
Ostash B, Saghatelian A, Walker S. A streamlined metabolic pathway for the biosynthesis of moenomycin A. Chemistry & Biology. 14: 257-67. PMID 17379141 DOI: 10.1016/J.Chembiol.2007.01.008 |
0.374 |
|
| 2007 |
Yuan Y, Barrett D, Zhang Y, Kahne D, Sliz P, Walker S. Crystal structure of a peptidoglycan glycosyltransferase suggests a model for processive glycan chain synthesis. Proceedings of the National Academy of Sciences of the United States of America. 104: 5348-53. PMID 17360321 DOI: 10.1073/Pnas.0701160104 |
0.817 |
|
| 2007 |
Dehennaut V, Lefebvre T, Sellier C, Leroy Y, Gross B, Walker S, Cacan R, Michalski JC, Vilain JP, Bodart JF. O-linked N-acetylglucosaminyltransferase inhibition prevents G2/M transition in Xenopus laevis oocytes. The Journal of Biological Chemistry. 282: 12527-36. PMID 17329255 DOI: 10.1074/Jbc.M700444200 |
0.705 |
|
| 2007 |
Zhang Y, Fechter EJ, Wang TS, Barrett D, Walker S, Kahne DE. Synthesis of heptaprenyl-lipid IV to analyze peptidoglycan glycosyltransferases. Journal of the American Chemical Society. 129: 3080-1. PMID 17323951 DOI: 10.1021/Ja069060G |
0.809 |
|
| 2006 |
Ginsberg C, Zhang YH, Yuan Y, Walker S. In vitro reconstitution of two essential steps in wall teichoic acid biosynthesis. Acs Chemical Biology. 1: 25-8. PMID 17163636 DOI: 10.1021/Cb0500041 |
0.827 |
|
| 2006 |
Zhang YH, Ginsberg C, Yuan Y, Walker S. Acceptor substrate selectivity and kinetic mechanism of Bacillus subtilis TagA. Biochemistry. 45: 10895-904. PMID 16953575 DOI: 10.1021/Bi060872Z |
0.825 |
|
| 2006 |
Fang X, Tiyanont K, Zhang Y, Wanner J, Boger D, Walker S. The mechanism of action of ramoplanin and enduracidin. Molecular Biosystems. 2: 69-76. PMID 16880924 DOI: 10.1039/B515328J |
0.818 |
|
| 2006 |
Tiyanont K, Doan T, Lazarus MB, Fang X, Rudner DZ, Walker S. Imaging peptidoglycan biosynthesis in Bacillus subtilis with fluorescent antibiotics. Proceedings of the National Academy of Sciences of the United States of America. 103: 11033-8. PMID 16832063 DOI: 10.1073/Pnas.0600829103 |
0.808 |
|
| 2006 |
Love KR, Swoboda JG, Noren CJ, Walker S. Enabling glycosyltransferase evolution: a facile substrate-attachment strategy for phage-display enzyme evolution. Chembiochem : a European Journal of Chemical Biology. 7: 753-6. PMID 16550625 DOI: 10.1002/Cbic.200600018 |
0.781 |
|
| 2005 |
Gross BJ, Kraybill BC, Walker S. Discovery of O-GlcNAc transferase inhibitors. Journal of the American Chemical Society. 127: 14588-9. PMID 16231908 DOI: 10.1021/Ja0555217 |
0.724 |
|
| 2005 |
Yuan Y, Chung HS, Leimkuhler C, Walsh CT, Kahne D, Walker S. In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides. Journal of the American Chemical Society. 127: 14128-9. PMID 16218575 DOI: 10.1021/Ja053704N |
0.743 |
|
| 2005 |
Ostash B, Walker S. Bacterial transglycosylase inhibitors. Current Opinion in Chemical Biology. 9: 459-66. PMID 16118062 DOI: 10.1016/J.Cbpa.2005.08.014 |
0.365 |
|
| 2005 |
Leimkuhler C, Chen L, Barrett D, Panzone G, Sun B, Falcone B, Oberthür M, Donadio S, Walker S, Kahne D. Differential inhibition of Staphylococcus aureus PBP2 by glycopeptide antibiotics. Journal of the American Chemical Society. 127: 3250-1. PMID 15755121 DOI: 10.1021/Ja043849E |
0.822 |
|
| 2005 |
Barrett D, Leimkuhler C, Chen L, Walker D, Kahne D, Walker S. Kinetic characterization of the glycosyltransferase module of Staphylococcus aureus PBP2. Journal of Bacteriology. 187: 2215-7. PMID 15743972 DOI: 10.1128/Jb.187.6.2215-2217.2005 |
0.822 |
|
| 2005 |
Walker S, Chen L, Hu Y, Rew Y, Shin D, Boger DL. Chemistry and biology of ramoplanin: a lipoglycodepsipeptide with potent antibiotic activity. Chemical Reviews. 105: 449-76. PMID 15700952 DOI: 10.1021/Cr030106N |
0.516 |
|
| 2004 |
Garneau S, Qiao L, Chen L, Walker S, Vederas JC. Synthesis of mono- and disaccharide analogs of moenomycin and lipid II for inhibition of transglycosylase activity of penicillin-binding protein 1b. Bioorganic & Medicinal Chemistry. 12: 6473-94. PMID 15556765 DOI: 10.1016/J.Bmc.2004.09.019 |
0.452 |
|
| 2004 |
Barrett DS, Chen L, Litterman NK, Walker S. Expression and characterization of the isolated glycosyltransferase module of Escherichia coli PBP1b. Biochemistry. 43: 12375-81. PMID 15379577 DOI: 10.1021/Bi049142M |
0.735 |
|
| 2004 |
Lee HY, Chung HS, Hang C, Khosla C, Walsh CT, Kahne D, Walker S. Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway. Journal of the American Chemical Society. 126: 9924-5. PMID 15303858 DOI: 10.1021/Ja048836F |
0.698 |
|
| 2004 |
Chen L, Yuan Y, Helm JS, Hu Y, Rew Y, Shin D, Boger DL, Walker S. Dissecting ramoplanin: mechanistic analysis of synthetic ramoplanin analogues as a guide to the design of improved antibiotics. Journal of the American Chemical Society. 126: 7462-3. PMID 15198592 DOI: 10.1021/Ja047879T |
0.821 |
|
| 2004 |
Hu Y, Helm JS, Chen L, Ginsberg C, Gross B, Kraybill B, Tiyanont K, Fang X, Wu T, Walker S. Identification of selective inhibitors for the glycosyltransferase MurG via high-throughput screening. Chemistry & Biology. 11: 703-11. PMID 15157881 DOI: 10.1016/J.Chembiol.2004.02.024 |
0.786 |
|
| 2003 |
Helm JS, Hu Y, Chen L, Gross B, Walker S. Identification of active-site inhibitors of MurG using a generalizable, high-throughput glycosyltransferase screen. Journal of the American Chemical Society. 125: 11168-9. PMID 16220917 DOI: 10.1021/Ja036494S |
0.79 |
|
| 2003 |
Hu Y, Helm JS, Chen L, Ye XY, Walker S. Ramoplanin inhibits bacterial transglycosylases by binding as a dimer to lipid II. Journal of the American Chemical Society. 125: 8736-7. PMID 12862463 DOI: 10.1021/Ja035217I |
0.795 |
|
| 2003 |
Chen L, Walker D, Sun B, Hu Y, Walker S, Kahne D. Vancomycin analogues active against vanA-resistant strains inhibit bacterial transglycosylase without binding substrate. Proceedings of the National Academy of Sciences of the United States of America. 100: 5658-63. PMID 12714684 DOI: 10.1073/Pnas.0931492100 |
0.786 |
|
| 2003 |
Breukink E, van Heusden HE, Vollmerhaus PJ, Swiezewska E, Brunner L, Walker S, Heck AJ, de Kruijff B. Lipid II is an intrinsic component of the pore induced by nisin in bacterial membranes. The Journal of Biological Chemistry. 278: 19898-903. PMID 12663672 DOI: 10.1074/Jbc.M301463200 |
0.365 |
|
| 2003 |
Hu Y, Chen L, Ha S, Gross B, Falcone B, Walker D, Mokhtarzadeh M, Walker S. Crystal structure of the MurG:UDP-GlcNAc complex reveals common structural principles of a superfamily of glycosyltransferases. Proceedings of the National Academy of Sciences of the United States of America. 100: 845-9. PMID 12538870 DOI: 10.1073/Pnas.0235749100 |
0.668 |
|
| 2002 |
Hu Y, Walker S. Remarkable structural similarities between diverse glycosyltransferases. Chemistry & Biology. 9: 1287-96. PMID 12498881 DOI: 10.1016/S1074-5521(02)00295-8 |
0.447 |
|
| 2002 |
Lazar K, Walker S. Substrate analogues to study cell-wall biosynthesis and its inhibition. Current Opinion in Chemical Biology. 6: 786-93. PMID 12470732 |
0.381 |
|
| 2002 |
Helm JS, Chen L, Walker S. Rethinking ramoplanin: the role of substrate binding in inhibition of peptidoglycan biosynthesis. Journal of the American Chemical Society. 124: 13970-1. PMID 12440876 DOI: 10.1021/Ja021097N |
0.808 |
|
| 2002 |
Chen L, Men H, Ha S, Ye XY, Brunner L, Hu Y, Walker S. Intrinsic lipid preferences and kinetic mechanism of Escherichia coli MurG. Biochemistry. 41: 6824-33. PMID 12022887 DOI: 10.1021/Bi0256678 |
0.744 |
|
| 2001 |
Ha S, Gross B, Walker S. E. Coli MurG: a paradigm for a superfamily of glycosyltransferases. Current Drug Targets. Infectious Disorders. 1: 201-13. PMID 12455415 DOI: 10.2174/1568005014606116 |
0.551 |
|
| 2001 |
Lo MC, Helm JS, Sarngadharan G, Pelczer I, Walker S. A new structure for the substrate-binding antibiotic ramoplanin. Journal of the American Chemical Society. 123: 8640-1. PMID 11525690 DOI: 10.1021/Ja011080P |
0.795 |
|
| 2001 |
Ye XY, Lo MC, Brunner L, Walker D, Kahne D, Walker S. Better substrates for bacterial transglycosylases. Journal of the American Chemical Society. 123: 3155-6. PMID 11457035 DOI: 10.1021/Ja010028Q |
0.777 |
|
| 2000 |
Ha S, Walker D, Shi Y, Walker S. The 1.9 A crystal structure of Escherichia coli MurG, a membrane-associated glycosyltransferase involved in peptidoglycan biosynthesis. Protein Science : a Publication of the Protein Society. 9: 1045-52. PMID 10892798 DOI: 10.1110/Ps.9.6.1045 |
0.511 |
|
| 2000 |
Kalben A, Pal S, Andreotti AH, Walker S, Gange D, Biswas K, Kahne D. Calicheamicin-DNA recognition: An analysis of seven different drug-DNA complexes Journal of the American Chemical Society. 122: 8403-8412. DOI: 10.1021/Ja0005183 |
0.651 |
|
| 2000 |
Lo MC, Men H, Branstrom A, Helm J, Yao N, Goldman R, Walker S. A new mechanism of action proposed for ramoplanin [10] Journal of the American Chemical Society. 122: 3540-3541. DOI: 10.1021/Ja000182X |
0.754 |
|
| 1999 |
Ha S, Chang E, Lo MC, Men H, Park P, Ge M, Walker S. The kinetic characterization of Escherichia coli MurG using synthetic substrate analogues Journal of the American Chemical Society. 121: X. DOI: 10.1021/Ja991556T |
0.805 |
|
| 1998 |
Lo MC, Ha S, Pelczer I, Pal S, Walker S. The solution structure of the DNA-binding domain of Skn-1. Proceedings of the National Academy of Sciences of the United States of America. 95: 8455-60. PMID 9671699 DOI: 10.1073/Pnas.95.15.8455 |
0.686 |
|
| 1998 |
Men H, Park P, Ge M, Walker S. Substrate synthesis and activity assay for MurG Journal of the American Chemical Society. 120: 2484-2485. DOI: 10.1021/Ja974221P |
0.587 |
|
| 1997 |
Bowe CL, Mokhtarzadeh L, Venkatesan P, Babu S, Axelrod HR, Sofia MJ, Kakarla R, Chan TY, Kim JS, Lee HJ, Amidon GL, Choe SY, Walker S, Kahne D. Design of compounds that increase the absorption of polar molecules. Proceedings of the National Academy of Sciences of the United States of America. 94: 12218-23. PMID 9342389 DOI: 10.1073/Pnas.94.22.12218 |
0.631 |
|
| 1997 |
Pal S, Lo MC, Schmidt D, Pelczer I, Thurber S, Walker S. Skn-1: evidence for a bipartite recognition helix in DNA binding. Proceedings of the National Academy of Sciences of the United States of America. 94: 5556-61. PMID 9159111 DOI: 10.1073/Pnas.94.11.5556 |
0.602 |
|
| 1996 |
Walker S, Sofia MJ, Kakarla R, Kogan NA, Wierichs L, Longley CB, Bruker K, Axelrod HR, Midha S, Babu S, Kahne D. Cationic facial amphiphiles: a promising class of transfection agents. Proceedings of the National Academy of Sciences of the United States of America. 93: 1585-90. PMID 8643675 DOI: 10.1073/Pnas.93.4.1585 |
0.644 |
|
| 1994 |
Walker S, Gupta V, Kahne D, Gange D. Analysis of Hydroxylamine Glycosidic Linkages: Structural Consequences of the NO Bond in Calicheamicin Journal of the American Chemical Society. 116: 3197-3206. DOI: 10.1021/Ja00087A005 |
0.635 |
|
| 1993 |
Walker S, Murnick J, Kahne D. Structural characterization of a calicheamicin-DNA complex by NMR Journal of the American Chemical Society. 115: 7954-7961. DOI: 10.1021/Ja00071A004 |
0.649 |
|
| 1992 |
Walker S, Landovitz R, Ding WD, Ellestad GA, Kahne D. Cleavage behavior of calicheamicin gamma 1 and calicheamicin T. Proceedings of the National Academy of Sciences of the United States of America. 89: 4608-12. PMID 1584797 DOI: 10.1073/Pnas.89.10.4608 |
0.616 |
|
| 1991 |
Walker S, Yang D, Kahne D, Gange D. Conformational analysis of the nitrogen-oxygen bond in the calicheamicin oligosaccharide Journal of the American Chemical Society. 113: 4716-4717. DOI: 10.1021/Ja00012A070 |
0.65 |
|
| 1990 |
Walker S, Valentine KG, Kahne D. Sugars as DNA binders: a comment on the calicheamicin oligosaccharide Journal of the American Chemical Society. 112: 6428-6429. DOI: 10.1021/Ja00173A058 |
0.623 |
|
| 1989 |
Kahne D, Walker S, Cheng Y, Engen DV. Glycosylation of unreactive substrates Journal of the American Chemical Society. 111: 6881-6882. DOI: 10.1021/Ja00199A081 |
0.655 |
|
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