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Roberto Melero - Publications

Affiliations: 
2004-2010 Macromolecular structure Natl. Center of Biotechnology (CSIC) 
 2010-2015 Macromolecular structure Center of Biological Research (CSIC) 
 2015- Macromolecular structure Natl. Center of Biotechnology (CSIC) 
Area:
Electron Microscopy; Single Particle Analysis
Website:
https://www.researchgate.net/profile/Roberto_Melero
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44 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Conesa P, Fonseca YC, Jiménez de la Morena J, Sharov G, de la Rosa-Trevín JM, Cuervo A, García Mena A, Rodríguez de Francisco B, Del Hoyo D, Herreros D, Marchan D, Strelak D, Fernández-Giménez E, Ramírez-Aportela E, de Isidro-Gómez FP, ... ... Melero R, et al. Scipion3: A workflow engine for cryo-electron microscopy image processing and structural biology. Biological Imaging. 3: e13. PMID 38510163 DOI: 10.1017/S2633903X23000132  0.74
2021 Sorrentino S, Conesa JJ, Cuervo A, Melero R, Martins B, Fernandez-Gimenez E, de Isidro-Gomez FP, de la Morena J, Studt JD, Sorzano COS, Eibauer M, Carazo JM, Medalia O. Structural analysis of receptors and actin polarity in platelet protrusions. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34504018 DOI: 10.1073/pnas.2105004118  0.483
2021 Lázaro M, Melero R, Huet C, López-Alonso JP, Delgado S, Dodu A, Bruch EM, Abriata LA, Alzari PM, Valle M, Lisa MN. 3D architecture and structural flexibility revealed in the subfamily of large glutamate dehydrogenases by a mycobacterial enzyme. Communications Biology. 4: 684. PMID 34083757 DOI: 10.1038/s42003-021-02222-x  0.588
2021 Lapenta F, Aupič J, Vezzoli M, Strmšek Ž, Da Vela S, Svergun DI, Carazo JM, Melero R, Jerala R. Author Correction: Self-assembly and regulation of protein cages from pre-organised coiled-coil modules. Nature Communications. 12: 1811. PMID 33727540 DOI: 10.1038/s41467-021-21969-9  0.428
2021 Lapenta F, Aupič J, Vezzoli M, Strmšek Ž, Da Vela S, Svergun DI, Carazo JM, Melero R, Jerala R. Self-assembly and regulation of protein cages from pre-organised coiled-coil modules. Nature Communications. 12: 939. PMID 33574245 DOI: 10.1038/s41467-021-21184-6  0.467
2020 Melero R, Sorzano COS, Foster B, Vilas JL, Martínez M, Marabini R, Ramírez-Aportela E, Sanchez-Garcia R, Herreros D, Del Caño L, Losana P, Fonseca-Reyna YC, Conesa P, Wrapp D, Chacon P, et al. Continuous flexibility analysis of SARS-CoV-2 spike prefusion structures. Iucrj. 7. PMID 33063791 DOI: 10.1107/S2052252520012725  0.638
2020 Melero R, Sorzano COS, Foster B, Vilas JL, Martínez M, Marabini R, Ramírez-Aportela E, Sanchez-Garcia R, Herreros D, Del Caño L, Losana P, Fonseca-Reyna YC, Conesa P, Wrapp D, Chacon P, et al. Continuous flexibility analysis of SARS-CoV-2 Spike prefusion structures. Biorxiv : the Preprint Server For Biology. PMID 32676604 DOI: 10.1101/2020.07.08.191072  0.648
2020 Carter SD, Hampton CM, Langlois R, Melero R, Farino ZJ, Calderon MJ, Li W, Wallace CT, Tran NH, Grassucci RA, Siegmund SE, Pemberton J, Morgenstern TJ, Eisenman L, Aguilar JI, et al. Ribosome-associated vesicles: A dynamic subcompartment of the endoplasmic reticulum in secretory cells. Science Advances. 6: eaay9572. PMID 32270040 DOI: 10.1126/Sciadv.Aay9572  0.612
2020 Martínez M, Jiménez-Moreno A, Maluenda D, Ramírez-Aportela E, Melero R, Cuervo A, Conesa P, Del Caño L, Fonseca YC, Sánchez-García R, Strelak D, Conesa JJ, Fernández-Giménez E, de Isidro F, Sorzano COS, et al. Integration of Cryo-EM Model Building Software in Scipion. Journal of Chemical Information and Modeling. PMID 31994878 DOI: 10.1021/Acs.Jcim.9B01032  0.809
2020 Vilas JL, Vargas J, Martinez M, Ramirez-Aportela E, Melero R, Jimenez-Moreno A, Garduño E, Conesa P, Marabini R, Maluenda D, Carazo JM, Sorzano COS. Re-examining the spectra of macromolecules. Current practice of spectral quasi B-factor flattening. Journal of Structural Biology. 107447. PMID 31911170 DOI: 10.1016/J.Jsb.2020.107447  0.794
2019 Peschiera I, Giuliani M, Giusti F, Melero R, Paccagnini E, Donnarumma D, Pansegrau W, Carazo JM, Sorzano COS, Scarselli M, Masignani V, Liljeroos LJ, Ferlenghi I. Structural basis for cooperativity of human monoclonal antibodies to meningococcal factor H-binding protein. Communications Biology. 2: 241. PMID 31925134 DOI: 10.1038/s42003-019-0493-4  0.471
2019 Maluenda D, Majtner T, Horvath P, Vilas JL, Jiménez-Moreno A, Mota J, Ramírez-Aportela E, Sánchez-García R, Conesa P, Del Caño L, Rancel Y, Fonseca Y, Martínez M, Sharov G, García CA, ... ... Melero R, et al. Flexible workflows for on-the-fly electron-microscopy single-particle image processing using Scipion. Acta Crystallographica. Section D, Structural Biology. 75: 882-894. PMID 31588920 DOI: 10.1107/S2059798319011860  0.798
2019 Ramírez-Aportela E, Vilas JL, Glukhova A, Melero R, Conesa P, Martínez M, Maluenda D, Mota J, Jiménez A, Vargas J, Marabini R, Sexton PM, Carazo JM, Oscar C, Sorzano S. Automatic local resolution-based sharpening of cryo-EM maps. Bioinformatics (Oxford, England). PMID 31504163 DOI: 10.1093/Bioinformatics/Btz671  0.773
2019 Peschiera I, Giuliani M, Giusti F, Melero R, Paccagnini E, Donnarumma D, Pansegrau W, Carazo JM, Sorzano COS, Scarselli M, Masignani V, Liljeroos LJ, Ferlenghi I. Structural basis for cooperativity of human monoclonal antibodies to meningococcal factor H-binding protein. Communications Biology. 2: 241. PMID 31263785 DOI: 10.1038/s42003-019-0493-4  0.471
2019 Busselez J, Chichón FJ, Rodríguez MJ, Alpízar A, Gharbi SI, Franch M, Melero R, Paradela A, Carrascosa JL, Carazo JM. Cryo-Electron Tomography and Proteomics studies of centrosomes from differentiated quiescent thymocytes. Scientific Reports. 9: 7187. PMID 31076588 DOI: 10.1038/S41598-019-43338-9  0.56
2019 Chicano A, Crosas E, Otón J, Melero R, Engel BD, Daban JR. Frozen-hydrated chromatin from metaphase chromosomes has an interdigitated multilayer structure. The Embo Journal. PMID 30609992 DOI: 10.15252/Embj.201899769  0.682
2019 Sorzano COS, Jiménez A, Mota J, Vilas JL, Maluenda D, Martínez M, Ramírez-Aportela E, Majtner T, Segura J, Sánchez-García R, Rancel Y, Del Caño L, Conesa P, Melero R, Jonic S, et al. Survey of the analysis of continuous conformational variability of biological macromolecules by electron microscopy. Acta Crystallographica. Section F, Structural Biology Communications. 75: 19-32. PMID 30605122 DOI: 10.1107/S2053230X18015108  0.759
2018 Jiménez A, Jonic S, Majtner T, Otón J, Vilas JL, Maluenda D, Mota J, Ramírez-Aportela E, Martínez M, Rancel Y, Segura J, Sánchez-García R, Melero R, Del Cano L, Conesa P, et al. Validation of Electron Microscopy Initial Models via Small Angle X-Ray Scattering Curves. Bioinformatics (Oxford, England). PMID 30500892 DOI: 10.1093/Bioinformatics/Bty985  0.741
2018 Gómez-Blanco J, de la Rosa-Trevín JM, Marabini R, Del Cano L, Jiménez A, Martínez M, Melero R, Majtner T, Maluenda D, Mota J, Rancel Y, Ramírez-Aportela E, Vilas JL, Carroni M, Fleischmann S, et al. Using Scipion for Stream Image Processing at Cryo-EM Facilities. Journal of Structural Biology. PMID 30296492 DOI: 10.1016/J.Jsb.2018.10.001  0.756
2018 Sorzano COS, Vargas J, de la Rosa-Trevín JM, Jiménez A, Maluenda D, Melero R, Martínez M, Ramírez-Aportela E, Conesa P, Vilas JL, Marabini R, Carazo JM. A new algorithm for high-resolution reconstruction of single particles by electron microscopy. Journal of Structural Biology. PMID 30145327 DOI: 10.1016/J.Jsb.2018.08.002  0.819
2018 Sacristan C, Ahmad MUD, Keller J, Fermie J, Groenewold V, Tromer E, Fish A, Melero R, Carazo JM, Klumperman J, Musacchio A, Perrakis A, Kops GJ. Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis. Nature Cell Biology. PMID 29915359 DOI: 10.1038/S41556-018-0130-3  0.523
2018 Sorzano COS, Fernández-Giménez E, Peredo-Robinson V, Vargas J, Majtner T, Caffarena G, Otón J, Vilas JL, de la Rosa-Trevín JM, Melero R, Gómez-Blanco J, Cuenca J, Del Cano L, Conesa P, Marabini R, et al. Blind estimation of DED camera gain in Electron Microscopy. Journal of Structural Biology. PMID 29551714 DOI: 10.1016/J.Jsb.2018.03.007  0.79
2018 Vilas JL, Gómez-Blanco J, Conesa P, Melero R, Miguel de la Rosa-Trevín J, Otón J, Cuenca J, Marabini R, Carazo JM, Vargas J, Sorzano COS. MonoRes: Automatic and Accurate Estimation of Local Resolution for Electron Microscopy Maps. Structure (London, England : 1993). 26: 337-344.e4. PMID 29395788 DOI: 10.1016/J.Str.2017.12.018  0.799
2017 Sorzano COS, Vargas J, Otón J, de la Rosa-Trevín JM, Vilas JL, Kazemi M, Melero R, Del Caño L, Cuenca J, Conesa P, Gómez-Blanco J, Marabini R, Carazo JM. A Survey of the Use of Iterative Reconstruction Algorithms in Electron Microscopy. Biomed Research International. 2017: 6482567. PMID 29312997 DOI: 10.1155/2017/6482567  0.794
2017 Ljubetič A, Lapenta F, Gradišar H, Drobnak I, Aupič J, Strmšek Ž, Lainšček D, Hafner-Bratkovič I, Majerle A, Krivec N, Benčina M, Pisanski T, Veličković TĆ, Round A, Carazo JM, ... Melero R, et al. Design of coiled-coil protein-origami cages that self-assemble in vitro and in vivo. Nature Biotechnology. 35: 1094-1101. PMID 29035374 DOI: 10.1038/Nbt.3994  0.548
2017 Albanese P, Melero R, Engel BD, Grinzato A, Berto P, Manfredi M, Chiodoni A, Vargas J, Sorzano CÓS, Marengo E, Saracco G, Zanotti G, Carazo JM, Pagliano C. Pea PSII-LHCII supercomplexes form pairs by making connections across the stromal gap. Scientific Reports. 7: 10067. PMID 28855679 DOI: 10.1038/S41598-017-10700-8  0.343
2017 Vargas J, Melero R, Gómez-Blanco J, Carazo JM, Sorzano COS. Quantitative analysis of 3D alignment quality: its impact on soft-validation, particle pruning and homogeneity analysis. Scientific Reports. 7: 6307. PMID 28740215 DOI: 10.1038/S41598-017-06526-Z  0.644
2017 Calles-Garcia D, Yang M, Soya N, Melero R, Ménade M, Ito Y, Vargas J, Lukacs GL, Kollman JM, Kozlov G, Gehring K. Single-particle electron microscopy structure of UDP-glucose:glycoprotein glucosyltransferase suggests a selectivity mechanism for misfolded proteins. The Journal of Biological Chemistry. PMID 28490633 DOI: 10.1074/Jbc.M117.789495  0.404
2016 Vilas JL, Navas J, Gómez-Blanco J, de la Rosa-Trevín JM, Melero R, Peschiera I, Ferlenghi I, Cuenca J, Marabini R, Carazo JM, Vargas J, Sorzano COS. Fast and automatic identification of particle tilt pairs based on Delaunay triangulation. Journal of Structural Biology. 196: 525-533. PMID 27769763 DOI: 10.1016/J.Jsb.2016.10.007  0.746
2016 Sorzano CO, Martín-Ramos A, Prieto F, Melero R, Martín-Benito J, Jonic S, Navas-Calvente J, Vargas J, Otón J, Abrishami V, de la Rosa-Trevín JM, Gómez-Blanco J, Vilas JL, Marabini R, Carazo JM. Local analysis of strains and rotations for macromolecular electron microscopy maps. Journal of Structural Biology. 195: 123-8. PMID 27102900 DOI: 10.1016/J.Jsb.2016.04.001  0.772
2016 Jonić S, Vargas J, Melero R, Gómez-Blanco J, Carazo JM, Sorzano CO. Denoising of high-resolution single-particle electron-microscopy density maps by their approximation using three-dimensional Gaussian functions. Journal of Structural Biology. 194: 423-33. PMID 27085420 DOI: 10.1016/J.Jsb.2016.04.007  0.651
2016 Melero R, Hug N, López-Perrote A, Yamashita A, Cáceres JF, Llorca O. The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation. Nature Communications. 7: 10585. PMID 26841701 DOI: 10.1038/Ncomms10585  0.572
2016 López-Perrote A, Castaño R, Melero R, Zamarro T, Kurosawa H, Ohnishi T, Uchiyama A, Aoyagi K, Buchwald G, Kataoka N, Yamashita A, Llorca O. Human nonsense-mediated mRNA decay factor UPF2 interacts directly with eRF3 and the SURF complex. Nucleic Acids Research. 44: 1909-23. PMID 26740584 DOI: 10.1093/Nar/Gkv1527  0.575
2016 Melero R, Hug N, Lopez-Perrote A, Yamashita A, Caceres JF, Llorca O. The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation Nature Communications. 7. DOI: 10.1038/ncomms10585  0.469
2015 Sorzano CO, Alcorlo M, de la Rosa-Trevín JM, Melero R, Foche I, Zaldívar-Peraza A, del Cano L, Vargas J, Abrishami V, Otón J, Marabini R, Carazo JM. Cryo-EM and the elucidation of new macromolecular structures: Random Conical Tilt revisited. Scientific Reports. 5: 14290. PMID 26390853 DOI: 10.1038/Srep14290  0.8
2015 Melero R, Moro F, Pérez-Calvo MÁ, Perales-Calvo J, Quintana-Gallardo L, Llorca O, Muga A, Valpuesta JM. Modulation of the chaperone DnaK allosterism by the nucleotide exchange factor GrpE Journal of Biological Chemistry. 290: 10083-10092. PMID 25739641 DOI: 10.1074/Jbc.M114.623371  0.58
2014 Melero R, Uchiyama A, Castaño R, Kataoka N, Kurosawa H, Ohno S, Yamashita A, Llorca O. Structures of SMG1-UPFs complexes: SMG1 contributes to regulate UPF2-dependent activation of UPF1 in NMD. Structure (London, England : 1993). 22: 1105-19. PMID 25002321 DOI: 10.1016/J.Str.2014.05.015  0.59
2012 Melero R, Buchwald G, Castaño R, Raabe M, Gil D, Lázaro M, Urlaub H, Conti E, Llorca O. The cryo-EM structure of the UPF-EJC complex shows UPF1 poised toward the RNA 3' end. Nature Structural & Molecular Biology. 19: 498-505, S1-2. PMID 22522823 DOI: 10.1038/Nsmb.2287  0.582
2011 Núñez-Ramírez R, Klinge S, Sauguet L, Melero R, Recuero-Checa MA, Kilkenny M, Perera RL, García-Alvarez B, Hall RJ, Nogales E, Pellegrini L, Llorca O. Flexible tethering of primase and DNA Pol α in the eukaryotic primosome. Nucleic Acids Research. 39: 8187-99. PMID 21715379 DOI: 10.1093/Nar/Gkr534  0.613
2011 García-Alvarez B, Melero R, Dias FM, Prates JA, Fontes CM, Smith SP, Romão MJ, Carvalho AL, Llorca O. Molecular architecture and structural transitions of a Clostridium thermocellum mini-cellulosome. Journal of Molecular Biology. 407: 571-80. PMID 21315080 DOI: 10.1016/J.Jmb.2011.01.060  0.619
2011 Melero R, Rajagopalan S, Lázaro M, Joerger AC, Brandt T, Veprintsev DB, Lasso G, Gil D, Scheres SH, Carazo JM, Fersht AR, Valle M. Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA. Proceedings of the National Academy of Sciences of the United States of America. 108: 557-62. PMID 21178074 DOI: 10.1073/Pnas.1015520107  0.757
2010 Sorzano CO, Bilbao-Castro JR, Shkolnisky Y, Alcorlo M, Melero R, Caffarena-Fernández G, Li M, Xu G, Marabini R, Carazo JM. A clustering approach to multireference alignment of single-particle projections in electron microscopy. Journal of Structural Biology. 171: 197-206. PMID 20362059 DOI: 10.1016/J.Jsb.2010.03.011  0.72
2009 Scheres SHW, Melero R, Valle M, Carazo JM. Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization. Structure (London, England : 1993). 17: 1563-1572. PMID 20004160 DOI: 10.1016/J.Str.2009.10.009  0.769
2007 Tidow H, Melero R, Mylonas E, Freund SM, Grossmann JG, Carazo JM, Svergun DI, Valle M, Fersht AR. Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex. Proceedings of the National Academy of Sciences of the United States of America. 104: 12324-9. PMID 17620598 DOI: 10.1073/Pnas.0705069104  0.75
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