Sjors Scheres - Publications

2004-2011 Natl. Center of Biotechnology (CSIC) 
 2011- MRC Laboratory of Molecular Biology, Cambridge, England, United Kingdom 
Electron microscopy; single particle analysis; image processing

57 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Scheres SH, Nagai K. CryoEM structures of spliceosomal complexes reveal the molecular mechanism of pre-mRNA splicing. Current Opinion in Structural Biology. 46: 130-139. PMID 28888105 DOI: 10.1016/  0.48
2017 Fitzpatrick AWP, Llabrés S, Neuberger A, Blaza JN, Bai XC, Okada U, Murakami S, van Veen HW, Zachariae U, Scheres SHW, Luisi BF, Du D. Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump. Nature Microbiology. 2: 17070. PMID 28504659 DOI: 10.1038/nmicrobiol.2017.70  0.48
2017 Wong W, Bai XC, Sleebs BE, Triglia T, Brown A, Thompson JK, Jackson KE, Hanssen E, Marapana DS, Fernandez IS, Ralph SA, Cowman AF, Scheres SH, Baum J. Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis. Nature Microbiology. 2: 17031. PMID 28288098 DOI: 10.1038/nmicrobiol.2017.31  0.48
2017 Boland A, Martin TG, Zhang Z, Yang J, Bai XC, Chang L, Scheres SH, Barford D. Cryo-EM structure of a metazoan separase-securin complex at near-atomic resolution. Nature Structural & Molecular Biology. PMID 28263324 DOI: 10.1038/nsmb.3386  0.48
2017 Li Y, Zhou M, Hu Q, Bai XC, Huang W, Scheres SH, Shi Y. Mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme. Proceedings of the National Academy of Sciences of the United States of America. PMID 28143931 DOI: 10.1073/pnas.1620626114  0.48
2016 Martin TG, Bharat TA, Joerger AC, Bai XC, Praetorius F, Fersht AR, Dietz H, Scheres SH. Design of a molecular support for cryo-EM structure determination. Proceedings of the National Academy of Sciences of the United States of America. PMID 27821763 DOI: 10.1073/pnas.1612720113  0.48
2016 Löwe J, He S, Scheres SH, Savva CG. X-ray and cryo-EM structures of monomeric and filamentous actin-like protein MamK reveal changes associated with polymerization. Proceedings of the National Academy of Sciences of the United States of America. PMID 27821762 DOI: 10.1073/pnas.1612034113  0.48
2016 Bharat TA, Scheres SH. Resolving macromolecular structures from electron cryo-tomography data using subtomogram averaging in RELION. Nature Protocols. 11: 2054-65. PMID 27685097 DOI: 10.1038/nprot.2016.124  0.32
2016 Nguyen TH, Galej WP, Bai XC, Oubridge C, Newman AJ, Scheres SH, Nagai K. Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution. Nature. PMID 26829225 DOI: 10.1038/nature16940  1
2015 Bai XC, Rajendra E, Yang G, Shi Y, Scheres SH. Sampling the conformational space of the catalytic subunit of human γ-secretase. Elife. 4. PMID 26623517 DOI: 10.7554/eLife.11182  1
2015 Zhou M, Li Y, Hu Q, Bai XC, Huang W, Yan C, Scheres SH, Shi Y. Atomic structure of the apoptosome: mechanism of cytochrome c- and dATP-mediated activation of Apaf-1. Genes & Development. PMID 26543158 DOI: 10.1101/gad.272278.115  0.48
2015 Fernández-Leiro R, Conrad J, Scheres SH, Lamers MH. cryo-EM structures of the E. coli replicative DNA polymerase reveal dynamic interactions with clamp, exonuclease and τ. Elife. 4. PMID 26499492 DOI: 10.7554/eLife.11134  1
2015 Bai XC, Yan C, Yang G, Lu P, Ma D, Sun L, Zhou R, Scheres SH, Shi Y. An atomic structure of human γ-secretase. Nature. 525: 212-7. PMID 26280335 DOI: 10.1038/nature14892  0.48
2015 Bharat TA, Russo CJ, Löwe J, Passmore LA, Scheres SH. Advances in Single-Particle Electron Cryomicroscopy Structure Determination applied to Sub-tomogram Averaging. Structure (London, England : 1993). 23: 1743-53. PMID 26256537 DOI: 10.1016/j.str.2015.06.026  1
2015 Nguyen TH, Galej WP, Bai XC, Savva CG, Newman AJ, Scheres SH, Nagai K. The architecture of the spliceosomal U4/U6.U5 tri-snRNP. Nature. 523: 47-52. PMID 26106855 DOI: 10.1038/nature14548  1
2015 Nogales E, Scheres SH. Cryo-EM: A Unique Tool for the Visualization of Macromolecular Complexity. Molecular Cell. 58: 677-689. PMID 26000851 DOI: 10.1016/j.molcel.2015.02.019  1
2015 Amunts A, Brown A, Toots J, Scheres SH, Ramakrishnan V. Ribosome. The structure of the human mitochondrial ribosome. Science (New York, N.Y.). 348: 95-8. PMID 25838379 DOI: 10.1126/science.aaa1193  1
2015 Pang Y, Bai XC, Yan C, Hao Q, Chen Z, Wang JW, Scheres SH, Shi Y. Structure of the apoptosome: mechanistic insights into activation of an initiator caspase from Drosophila. Genes & Development. 29: 277-87. PMID 25644603 DOI: 10.1101/gad.255877.114  0.48
2015 Wood C, Burnley T, Patwardhan A, Scheres S, Topf M, Roseman A, Winn M. Collaborative computational project for electron cryo-microscopy. Acta Crystallographica. Section D, Biological Crystallography. 71: 123-6. PMID 25615866 DOI: 10.1107/S1399004714018070  1
2015 Bai XC, McMullan G, Scheres SH. How cryo-EM is revolutionizing structural biology. Trends in Biochemical Sciences. 40: 49-57. PMID 25544475 DOI: 10.1016/j.tibs.2014.10.005  0.48
2015 Yan Z, Bai XC, Yan C, Wu J, Li Z, Xie T, Peng W, Yin CC, Li X, Scheres SH, Shi Y, Yan N. Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution. Nature. 517: 50-5. PMID 25517095 DOI: 10.1038/nature14063  1
2014 Brown A, Amunts A, Bai XC, Sugimoto Y, Edwards PC, Murshudov G, Scheres SH, Ramakrishnan V. Structure of the large ribosomal subunit from human mitochondria. Science (New York, N.Y.). 346: 718-22. PMID 25278503 DOI: 10.1126/science.1258026  1
2014 Lu P, Bai XC, Ma D, Xie T, Yan C, Sun L, Yang G, Zhao Y, Zhou R, Scheres SH, Shi Y. Three-dimensional structure of human γ-secretase. Nature. 512: 166-70. PMID 25043039 DOI: 10.1038/nature13567  0.48
2014 Voorhees RM, Fernández IS, Scheres SH, Hegde RS. Structure of the mammalian ribosome-Sec61 complex to 3.4 Å resolution. Cell. 157: 1632-43. PMID 24930395 DOI: 10.1016/j.cell.2014.05.024  1
2014 Wong W, Bai XC, Brown A, Fernandez IS, Hanssen E, Condron M, Tan YH, Baum J, Scheres SH. Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine. Elife. 3. PMID 24913268 DOI: 10.7554/eLife.03080  0.48
2014 Fernández IS, Bai XC, Murshudov G, Scheres SH, Ramakrishnan V. Initiation of translation by cricket paralysis virus IRES requires its translocation in the ribosome. Cell. 157: 823-31. PMID 24792965 DOI: 10.1016/j.cell.2014.04.015  1
2014 Amunts A, Brown A, Bai XC, Llácer JL, Hussain T, Emsley P, Long F, Murshudov G, Scheres SH, Ramakrishnan V. Structure of the yeast mitochondrial large ribosomal subunit. Science (New York, N.Y.). 343: 1485-9. PMID 24675956 DOI: 10.1126/science.1249410  1
2014 Muench SP, Scheres SH, Huss M, Phillips C, Vitavska O, Wieczorek H, Trinick J, Harrison MA. Subunit positioning and stator filament stiffness in regulation and power transmission in the V1 motor of the Manduca sexta V-ATPase. Journal of Molecular Biology. 426: 286-300. PMID 24075871 DOI: 10.1016/j.jmb.2013.09.018  1
2013 Fernández IS, Bai XC, Hussain T, Kelley AC, Lorsch JR, Ramakrishnan V, Scheres SH. Molecular architecture of a eukaryotic translational initiation complex. Science (New York, N.Y.). 342: 1240585. PMID 24200810 DOI: 10.1126/science.1240585  1
2013 Chen S, McMullan G, Faruqi AR, Murshudov GN, Short JM, Scheres SH, Henderson R. High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy. Ultramicroscopy. 135: 24-35. PMID 23872039 DOI: 10.1016/j.ultramic.2013.06.004  0.4
2013 Sauerwald A, Sandin S, Cristofari G, Scheres SH, Lingner J, Rhodes D. Structure of active dimeric human telomerase. Nature Structural & Molecular Biology. 20: 454-60. PMID 23474713 DOI: 10.1038/nsmb.2530  1
2013 Bai XC, Fernandez IS, McMullan G, Scheres SH. Ribosome structures to near-atomic resolution from thirty thousand cryo-EM particles. Elife. 2: e00461. PMID 23427024 DOI: 10.7554/eLife.00461  0.48
2012 Patwardhan A, Carazo JM, Carragher B, Henderson R, Heymann JB, Hill E, Jensen GJ, Lagerstedt I, Lawson CL, Ludtke SJ, Mastronarde D, Moore WJ, Roseman A, Rosenthal P, Sorzano CO, ... ... Scheres SH, et al. Data management challenges in three-dimensional EM. Nature Structural & Molecular Biology. 19: 1203-7. PMID 23211764 DOI: 10.1038/nsmb.2426  1
2012 Bai XC, Martin TG, Scheres SH, Dietz H. Cryo-EM structure of a 3D DNA-origami object. Proceedings of the National Academy of Sciences of the United States of America. 109: 20012-7. PMID 23169645 DOI: 10.1073/pnas.1215713109  1
2011 Melero R, Rajagopalan S, Lázaro M, Joerger AC, Brandt T, Veprintsev DB, Lasso G, Gil D, Scheres SH, Carazo JM, Fersht AR, Valle M. Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA. Proceedings of the National Academy of Sciences of the United States of America. 108: 557-62. PMID 21178074 DOI: 10.1073/pnas.1015520107  1
2011 Stölken M, Beck F, Haller T, Hegerl R, Gutsche I, Carazo JM, Baumeister W, Scheres SH, Nickell S. Maximum likelihood based classification of electron tomographic data. Journal of Structural Biology. 173: 77-85. PMID 20719249 DOI: 10.1016/j.jsb.2010.08.005  1
2010 Sigworth FJ, Doerschuk PC, Carazo JM, Scheres SH. An introduction to maximum-likelihood methods in cryo-EM. Methods in Enzymology. 482: 263-94. PMID 20888965 DOI: 10.1016/S0076-6879(10)82011-7  1
2010 Ortiz JO, Brandt F, Matias VR, Sennels L, Rappsilber J, Scheres SH, Eibauer M, Hartl FU, Baumeister W. Structure of hibernating ribosomes studied by cryoelectron tomography in vitro and in situ. The Journal of Cell Biology. 190: 613-21. PMID 20733057 DOI: 10.1083/jcb.201005007  1
2010 Cuesta I, Núñez-Ramírez R, Scheres SH, Gai D, Chen XS, Fanning E, Carazo JM. Conformational rearrangements of SV40 large T antigen during early replication events. Journal of Molecular Biology. 397: 1276-86. PMID 20219473 DOI: 10.1016/j.jmb.2010.02.042  1
2010 Cheng K, Ivanova N, Scheres SH, Pavlov MY, Carazo JM, Hebert H, Ehrenberg M, Lindahl M. tmRNA.SmpB complex mimics native aminoacyl-tRNAs in the A site of stalled ribosomes. Journal of Structural Biology. 169: 342-8. PMID 19883769 DOI: 10.1016/j.jsb.2009.10.015  1
2009 Scheres SHW, Melero R, Valle M, Carazo JM. Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization. Structure (London, England : 1993). 17: 1563-1572. PMID 20004160 DOI: 10.1016/j.str.2009.10.009  1
2009 Nickell S, Beck F, Scheres SH, Korinek A, Förster F, Lasker K, Mihalache O, Sun N, Nagy I, Sali A, Plitzko JM, Carazo JM, Mann M, Baumeister W. Insights into the molecular architecture of the 26S proteasome. Proceedings of the National Academy of Sciences of the United States of America. 106: 11943-7. PMID 19581588 DOI: 10.1073/pnas.0905081106  1
2009 Scheres SH, Carazo JM. Introducing robustness to maximum-likelihood refinement of electron-microscopy data. Acta Crystallographica. Section D, Biological Crystallography. 65: 672-8. PMID 19564687 DOI: 10.1107/S0907444909012049  1
2009 Pérez-Berná AJ, Marabini R, Scheres SH, Menéndez-Conejero R, Dmitriev IP, Curiel DT, Mangel WF, Flint SJ, San Martín C. Structure and uncoating of immature adenovirus. Journal of Molecular Biology. 392: 547-57. PMID 19563809 DOI: 10.1016/j.jmb.2009.06.057  1
2009 Scheres SH, Valle M, Grob P, Nogales E, Carazo JM. Maximum likelihood refinement of electron microscopy data with normalization errors. Journal of Structural Biology. 166: 234-40. PMID 19236920 DOI: 10.1016/j.jsb.2009.02.007  1
2008 Julián P, Konevega AL, Scheres SH, Lázaro M, Gil D, Wintermeyer W, Rodnina MV, Valle M. Structure of ratcheted ribosomes with tRNAs in hybrid states. Proceedings of the National Academy of Sciences of the United States of America. 105: 16924-7. PMID 18971332 DOI: 10.1073/pnas.0809587105  1
2008 Cuéllar J, Martín-Benito J, Scheres SH, Sousa R, Moro F, López-Viñas E, Gómez-Puertas P, Muga A, Carrascosa JL, Valpuesta JM. The structure of CCT-Hsc70 NBD suggests a mechanism for Hsp70 delivery of substrates to the chaperonin. Nature Structural & Molecular Biology. 15: 858-64. PMID 18660820 DOI: 10.1038/nsmb.1464  0.76
2008 Scheres SH, Núñez-Ramírez R, Sorzano CO, Carazo JM, Marabini R. Image processing for electron microscopy single-particle analysis using XMIPP. Nature Protocols. 3: 977-90. PMID 18536645 DOI: 10.1038/nprot.2008.62  1
2007 Scheres SH, Núñez-Ramírez R, Gómez-Llorente Y, San Martín C, Eggermont PP, Carazo JM. Modeling experimental image formation for likelihood-based classification of electron microscopy data. Structure (London, England : 1993). 15: 1167-77. PMID 17937907 DOI: 10.1016/j.str.2007.09.003  1
2007 Agirrezabala X, Velázquez-Muriel JA, Gómez-Puertas P, Scheres SH, Carazo JM, Carrascosa JL. Quasi-atomic model of bacteriophage t7 procapsid shell: insights into the structure and evolution of a basic fold. Structure (London, England : 1993). 15: 461-72. PMID 17437718 DOI: 10.1016/j.str.2007.03.004  0.76
2007 Scheres SH, Gao H, Valle M, Herman GT, Eggermont PP, Frank J, Carazo JM. Disentangling conformational states of macromolecules in 3D-EM through likelihood optimization. Nature Methods. 4: 27-9. PMID 17179934 DOI: 10.1038/nmeth992  1
2005 Scheres SH, Valle M, Carazo JM. Fast maximum-likelihood refinement of electron microscopy images. Bioinformatics (Oxford, England). 21: ii243-4. PMID 16204112 DOI: 10.1093/bioinformatics/bti1140  1
2005 Scheres SH, Marabini R, Lanzavecchia S, Cantele F, Rutten T, Fuller SD, Carazo JM, Burnett RM, San Martín C. Classification of single-projection reconstructions for cryo-electron microscopy data of icosahedral viruses. Journal of Structural Biology. 151: 79-91. PMID 15923127 DOI: 10.1016/j.jsb.2005.04.003  0.76
2005 Scheres SH, Valle M, Nuñez R, Sorzano CO, Marabini R, Herman GT, Carazo JM. Maximum-likelihood multi-reference refinement for electron microscopy images. Journal of Molecular Biology. 348: 139-49. PMID 15808859 DOI: 10.1016/j.jmb.2005.02.031  1
2005 Velázquez-Muriel JA, Sorzano CO, Scheres SH, Carazo JM. SPI-EM: towards a tool for predicting CATH superfamilies in 3D-EM maps. Journal of Molecular Biology. 345: 759-71. PMID 15588824 DOI: 10.1016/j.jmb.2004.11.005  1
2004 Scheres SH, Gros P. The potentials of conditional optimization in phasing and model building of protein crystal structures. Acta Crystallographica. Section D, Biological Crystallography. 60: 2202-9. PMID 15572773 DOI: 10.1107/S0907444904008996  1
2003 Scheres SH, Gros P. Development of a force field for conditional optimization of protein structures. Acta Crystallographica. Section D, Biological Crystallography. 59: 438-46. PMID 12595700 DOI: 10.1107/S0907444902022850  1
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