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Tomas Malinauskas - Publications

Affiliations: 
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 
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33 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Hillier J, Zhao Y, Carrique L, Malinauskas T, Ruza RR, Chang TH, Yi G, Duyvesteyn HME, Yu J, Lu W, Pardon E, Steyaert J, Zhu Y, Ni T, Jones EY. Structural insights into Frizzled3 through nanobody modulators. Nature Communications. 15: 7228. PMID 39174501 DOI: 10.1038/s41467-024-51451-1  0.351
2024 Malinauskas T, Moore G, Rudolf AF, Eggington H, Belnoue-Davis HL, El Omari K, Griffiths SC, Woolley RE, Duman R, Wagner A, Leedham SJ, Baldock C, Ashe HL, Siebold C. Molecular mechanism of BMP signal control by Twisted gastrulation. Nature Communications. 15: 4976. PMID 38862520 DOI: 10.1038/s41467-024-49065-8  0.368
2022 Sente A, Desai R, Naydenova K, Malinauskas T, Jounaidi Y, Miehling J, Zhou X, Masiulis S, Hardwick SW, Chirgadze DY, Miller KW, Aricescu AR. Differential assembly diversifies GABA receptor structures and signalling. Nature. 604: 190-194. PMID 35355020 DOI: 10.1038/s41586-022-04517-3  0.43
2021 Griffiths SC, Schwab RA, El Omari K, Bishop B, Iverson EJ, Malinauskas T, Dubey R, Qian M, Covey DF, Gilbert RJC, Rohatgi R, Siebold C. Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. Nature Communications. 12: 7171. PMID 34887403 DOI: 10.1038/s41467-021-27475-2  0.361
2021 Robinson RA, Griffiths SC, van de Haar LL, Malinauskas T, van Battum EY, Zelina P, Schwab RA, Karia D, Malinauskaite L, Brignani S, van den Munkhof MH, Düdükcü Ö, De Ruiter AA, Van den Heuvel DMA, Bishop B, et al. Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling. Cell. PMID 33740419 DOI: 10.1016/j.cell.2021.02.045  0.395
2020 Zhou D, Duyvesteyn HME, Chen CP, Huang CG, Chen TH, Shih SR, Lin YC, Cheng CY, Cheng SH, Huang YC, Lin TY, Ma C, Huo J, Carrique L, Malinauskas T, et al. Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient. Nature Structural & Molecular Biology. PMID 32737466 DOI: 10.1038/S41594-020-0480-Y  0.389
2020 McGough IJ, Vecchia L, Bishop B, Malinauskas T, Beckett K, Joshi D, O'Reilly N, Siebold C, Jones EY, Vincent JP. Glypicans shield the Wnt lipid moiety to enable signalling at a distance. Nature. PMID 32699409 DOI: 10.1038/S41586-020-2498-Z  0.389
2020 Huo J, Le Bas A, Ruza RR, Duyvesteyn HME, Mikolajek H, Malinauskas T, Tan TK, Rijal P, Dumoux M, Ward PN, Ren J, Zhou D, Harrison PJ, Weckener M, Clare DK, et al. Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2. Nature Structural & Molecular Biology. PMID 32661423 DOI: 10.1038/S41594-020-0469-6  0.356
2020 Huo J, Zhao Y, Ren J, Zhou D, Duyvesteyn HME, Ginn HM, Carrique L, Malinauskas T, Ruza RR, Shah PNM, Tan TK, Rijal P, Coombes N, Bewley KR, Tree JA, et al. Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike. Cell Host & Microbe. PMID 32585135 DOI: 10.1016/J.Chom.2020.06.010  0.382
2020 Malinauskas T, Peer TV, Bishop B, Mueller TD, Siebold C. Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex. Proceedings of the National Academy of Sciences of the United States of America. PMID 32576689 DOI: 10.1073/Pnas.2000561117  0.49
2020 Dubey R, van Kerkhof P, Jordens I, Malinauskas T, Pusapati GV, McKenna JK, Li D, Carette JE, Ho M, Siebold C, Maurice M, Lebensohn AM, Rohatgi R. R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling. Elife. 9. PMID 32432544 DOI: 10.7554/Elife.54469  0.5
2019 Rudolf AF, Kinnebrew M, Kowatsch C, Ansell TB, El Omari K, Bishop B, Pardon E, Schwab RA, Malinauskas T, Qian M, Duman R, Covey DF, Steyaert J, Wagner A, Sansom MSP, et al. The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism. Nature Chemical Biology. PMID 31548691 DOI: 10.1038/S41589-019-0370-Y  0.405
2019 Rozbesky D, Robinson RA, Jain V, Renner M, Malinauskas T, Harlos K, Siebold C, Jones EY. Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning. Nature Communications. 10: 3691. PMID 31417095 DOI: 10.1038/S41467-019-11683-Y  0.487
2019 Masiulis S, Desai R, Uchański T, Martin IS, Laverty D, Karia D, Malinauskas T, Zivanov J, Pardon E, Kotecha A, Steyaert J, Miller KW, Aricescu AR. Author Correction: GABA receptor signalling mechanisms revealed by structural pharmacology. Nature. PMID 30733619 DOI: 10.1038/S41586-019-0929-5  0.385
2019 Masiulis S, Desai R, Uchański T, Serna Martin I, Laverty D, Karia D, Malinauskas T, Zivanov J, Pardon E, Kotecha A, Steyaert J, Miller KW, Aricescu AR. GABA receptor signalling mechanisms revealed by structural pharmacology. Nature. PMID 30602790 DOI: 10.1038/s41586-018-0832-5  0.407
2019 Laverty D, Desai R, Uchański T, Masiulis S, Stec WJ, Malinauskas T, Zivanov J, Pardon E, Steyaert J, Miller KW, Aricescu AR. Cryo-EM structure of the human α1β3γ2 GABA receptor in a lipid bilayer. Nature. PMID 30602789 DOI: 10.1038/S41586-018-0833-4  0.439
2019 Laverty D, Desai R, Uchanski T, Masiulis S, Wojciech JS, Malinauskas T, Zivanov J, Pardon E, Steyaert J, Miller KW, Aricescu AR. Structure of the human alpha1beta3gamma2 GABA-A receptor in a lipid bilayer Nature. DOI: 10.2210/Pdb6I53/Pdb  0.359
2018 Gorvin CM, Frost M, Malinauskas T, Cranston T, Boon H, Siebold C, Jones EY, Hannan FM, Thakker RV. Calcium-sensing receptor residues with loss- and gain-of-function mutations are located in regions of conformational change and cause signalling bias Human Molecular Genetics. 27: 3720-3733. PMID 30052933 DOI: 10.1093/Hmg/Ddy263  0.371
2018 Gorvin CM, Babinsky VN, Malinauskas T, Nissen PH, Schou AJ, Hanyaloglu AC, Siebold C, Jones EY, Hannan FM, Thakker RV. A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin-biased signaling. Science Signaling. 11. PMID 29463778 DOI: 10.1126/Scisignal.Aan3714  0.418
2018 Malinauskas T, Bishop B, Mueller TD, Siebold C. Structural Basis for Growth Differentiation Factor 5 (GDF5) Signaling Inhibition by Repulsive Guidance Molecules (RGMs) Biophysical Journal. 114. DOI: 10.1016/J.Bpj.2017.11.2561  0.325
2016 Kong Y, Janssen BJ, Malinauskas T, Vangoor VR, Coles CH, Kaufmann R, Ni T, Gilbert RJ, Padilla-Parra S, Pasterkamp RJ, Jones EY. Structural Basis for Plexin Activation and Regulation. Neuron. 91: 548-60. PMID 27397516 DOI: 10.1016/J.Neuron.2016.06.018  0.426
2016 Malinauskas T, Furukawa H. Production of Heteromeric Transmembrane Receptors with Defined Subunit Stoichiometry. Structure (London, England : 1993). 24: 1008-1009. PMID 27276428 DOI: 10.1016/J.Str.2016.05.003  0.605
2016 Malinauskas T, Furukawa H. Production of Heteromeric Transmembrane Receptors with Defined Subunit Stoichiometry. Structure (London, England : 1993). 24: 653-5. PMID 27145073 DOI: 10.1016/J.Str.2016.04.004  0.634
2014 Malinauskas T, Jones EY. Extracellular modulators of Wnt signalling. Current Opinion in Structural Biology. 29: 77-84. PMID 25460271 DOI: 10.1016/J.Sbi.2014.10.003  0.512
2014 Zhao Y, Malinauskas T, Harlos K, Jones EY. Structural insights into the inhibition of Wnt signaling by cancer antigen 5T4/Wnt-activated inhibitory factor 1. Structure (London, England : 1993). 22: 612-20. PMID 24582434 DOI: 10.1016/J.Str.2014.01.009  0.357
2013 Nachtergaele S, Whalen DM, Mydock LK, Zhao Z, Malinauskas T, Krishnan K, Ingham PW, Covey DF, Siebold C, Rohatgi R. Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling. Elife. 2: e01340. PMID 24171105 DOI: 10.7554/Elife.01340  0.446
2013 Whalen DM, Malinauskas T, Gilbert RJ, Siebold C. Structural insights into proteoglycan-shaped Hedgehog signaling. Proceedings of the National Academy of Sciences of the United States of America. 110: 16420-5. PMID 24062467 DOI: 10.1073/Pnas.1310097110  0.431
2013 Nachtergaele S, Whalen DM, Mydock LK, Zhao Z, Malinauskas T, Krishnan K, Ingham PW, Covey DF, Siebold C, Rohatgi R. Author response: Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling Elife. DOI: 10.7554/Elife.01340.020  0.382
2012 Janssen BJ, Malinauskas T, Weir GA, Cader MZ, Siebold C, Jones EY. Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex. Nature Structural & Molecular Biology. 19: 1293-9. PMID 23104057 DOI: 10.1038/Nsmb.2416  0.535
2012 Malinauskas T, Aricescu RA, Weixian L, Siebold C, Jones YE. Modular Mechanism of Wnt Signalling Inhibition by Wnt Inhibitory Factor 1 Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.2834  0.412
2011 Chen S, Bubeck D, MacDonald BT, Liang WX, Mao JH, Malinauskas T, Llorca O, Aricescu AR, Siebold C, He X, Jones EY. Structural and functional studies of LRP6 ectodomain reveal a platform for Wnt signaling. Developmental Cell. 21: 848-61. PMID 22000855 DOI: 10.1016/J.Devcel.2011.09.007  0.467
2011 Malinauskas T, Aricescu AR, Lu W, Siebold C, Jones EY. Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1 Nature Structural & Molecular Biology. 18: 886-893. PMID 21743455 DOI: 10.1038/Nsmb.2081  0.424
2008 Malinauskas T. Docking of Fatty Acids into the WIF Domain of the Human Wnt Inhibitory Factor-1 Lipids. 43: 227-230. PMID 18256869 DOI: 10.1007/S11745-007-3144-3  0.378
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