| Year |
Citation |
Score |
| 2020 |
Coutinho Carneiro V, de Abreu da Silva IC, Amaral MS, Pereira ASA, Silveira GO, Pires DDS, Verjovski-Almeida S, Dekker FJ, Rotili D, Mai A, Lopes-Torres EJ, Robaa D, Sippl W, Pierce RJ, Borrello MT, ... Ganesan A, et al. Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni. Plos Neglected Tropical Diseases. 14: e0008332. PMID 32609727 DOI: 10.1371/Journal.Pntd.0008332 |
0.751 |
|
| 2020 |
Ho T, Chan A, Ganesan A. Thirty years of HDAC inhibitors: 2020 hindsight. Journal of Medicinal Chemistry. PMID 32608981 DOI: 10.1021/Acs.Jmedchem.0C00830 |
0.352 |
|
| 2020 |
Liang L, Wang H, Du Y, Luo B, Meng N, Cen M, Huang P, Ganesan A, Wen S. New tranylcypromine derivatives containing sulfonamide motif as potent LSD1 inhibitors to target acute myeloid leukemia: Design, synthesis and biological evaluation. Bioorganic Chemistry. 99: 103808. PMID 32334189 DOI: 10.1016/J.Bioorg.2020.103808 |
0.388 |
|
| 2019 |
Ferreira GM, Magalhães JG, Maltarollo VG, Kronenberger T, Ganesan A, Emery FDS, Trossini GHG. QSAR studies on the human sirtuin 2 inhibition by non-covalent 7,5,2-anilinobenzamide derivatives. Journal of Biomolecular Structure & Dynamics. 1-10. PMID 30789810 DOI: 10.1080/07391102.2019.1574603 |
0.35 |
|
| 2018 |
Vaidergorn MM, Carneiro ZA, Lopes CD, de Albuquerque S, Reis FCC, Nikolaou S, Mello JFRE, Genesi GL, Trossini GHG, Ganesan A, Emery FS. β-amino alcohols and their respective 2-phenyl-N-alkyl aziridines as potential DNA minor groove binders. European Journal of Medicinal Chemistry. 157: 657-664. PMID 30125724 DOI: 10.1016/J.Ejmech.2018.07.055 |
0.308 |
|
| 2018 |
Regufe da Mota S, Bailey S, Strivens RA, Hayden AL, Douglas LR, Duriez PJ, Borrello MT, Benelkebir H, Ganesan A, Packham G, Crabb SJ. LSD1 inhibition attenuates androgen receptor V7 splice variant activation in castration resistant prostate cancer models. Cancer Cell International. 18: 71. PMID 29760584 DOI: 10.1186/S12935-018-0568-1 |
0.72 |
|
| 2018 |
Ganesan A. Epigenetic drug discovery: a success story for cofactor interference. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 373. PMID 29685973 DOI: 10.1098/Rstb.2017.0069 |
0.35 |
|
| 2018 |
Lecointre B, Narozny R, Borrello MT, Senger J, Chakrabarti A, Jung M, Marek M, Romier C, Melesina J, Sippl W, Bischoff L, Ganesan A. Isoform-selective HDAC1/6/8 inhibitors with an imidazo-ketopiperazine cap containing stereochemical diversity. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 373. PMID 29685969 DOI: 10.1098/Rstb.2017.0364 |
0.767 |
|
| 2018 |
Silva AC, Benelkebir H, Lopes RSC, Lopes CC, Ganesan A. Total Synthesis of Altissimacoumarin D, a Small Molecule Sirtuin1 Activator Journal of the Brazilian Chemical Society. DOI: 10.21577/0103-5053.20180021 |
0.302 |
|
| 2017 |
Conforti F, Davies ER, Calderwood CJ, Thatcher TH, Jones MG, Smart DE, Mahajan S, Alzetani A, Havelock T, Maher TM, Molyneaux PL, Thorley AJ, Tetley TD, Warner JA, Packham G, ... Ganesan A, et al. The histone deacetylase inhibitor, romidepsin, as a potential treatment for pulmonary fibrosis. Oncotarget. PMID 28467787 DOI: 10.18632/Oncotarget.17114 |
0.329 |
|
| 2017 |
Borrello MT, Schinor B, Bartels K, Benelkebir H, Pereira S, Al-Jamal WT, Douglas L, Duriez PJ, Packham G, Haufe G, Ganesan A. Fluorinated tranylcypromine analogues as inhibitors of lysine-specific demethylase 1 (LSD1, KDM1A). Bioorganic & Medicinal Chemistry Letters. PMID 28390942 DOI: 10.1016/J.Bmcl.2017.03.081 |
0.746 |
|
| 2017 |
Hau M, Zenk F, Ganesan A, Iovino N, Jung M. Cellular analysis of the action of epigenetics drugs and probes. Epigenetics. 0. PMID 28071961 DOI: 10.1080/15592294.2016.1274472 |
0.319 |
|
| 2017 |
Peng X, Luo H, Wu F, Zhu D, Ganesan A, Huang P, Wen S. Synthesis of Fluorenes with an All‐Carbon Quaternary Center via Palladium‐Catalyzed Dual Arylation using Cyclic Diaryliodonium Triflates Advanced Synthesis & Catalysis. 359: 1152-1156. DOI: 10.1002/Adsc.201601260 |
0.302 |
|
| 2016 |
Shaheen F, Jabeen A, Ashraf S, Nadeem-Ul-Haque M, Shah ZA, Ziaee MA, Dastagir N, Ganesan A. Total synthesis, structural, and biological evaluation of stylissatin A and related analogs. Journal of Peptide Science : An Official Publication of the European Peptide Society. 22: 607-17. PMID 27526945 DOI: 10.1002/Psc.2909 |
0.3 |
|
| 2016 |
Ganesan A. Multitarget Drugs: an Epigenetic Epiphany. Chemmedchem. PMID 26891251 DOI: 10.1002/Cmdc.201500394 |
0.323 |
|
| 2016 |
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Ganesan AK, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356 |
0.31 |
|
| 2015 |
Maltarollo VG, Honório KM, Emery FS, Ganesan A, Trossini GH. Hologram quantitative structure-activity relationship and comparative molecular interaction field analysis of aminothiazole and thiazolesulfonamide as reversible LSD1 inhibitors. Future Medicinal Chemistry. 7: 1381-94. PMID 26230878 DOI: 10.4155/Fmc.15.68 |
0.372 |
|
| 2015 |
Malcomson T, Yelekci K, Borrello MT, Ganesan A, Semina E, De Kimpe N, Mangelinckx S, Ramsay RR. cis-cyclopropylamines as mechanism-based inhibitors of monoamine oxidases. The Febs Journal. PMID 25755053 DOI: 10.1111/Febs.13260 |
0.752 |
|
| 2015 |
Liu Q, Lu W, Ma M, Liao J, Ganesan A, Hu Y, Wen S, Huang P. Synthesis and biological evaluation of santacruzamate A and analogs as potential anticancer agents Rsc Advances. 5: 1109-1112. DOI: 10.1039/C4Ra13889A |
0.382 |
|
| 2014 |
Masuda Y, Tanaka R, Kai K, Ganesan A, Doi T. Total synthesis and biological evaluation of PF1171A, C, F, and G, cyclic hexapeptides with insecticidal activity. The Journal of Organic Chemistry. 79: 7844-53. PMID 25102055 DOI: 10.1021/Jo500861K |
0.317 |
|
| 2013 |
Robertson JC, Hurley NC, Tortorici M, Ciossani G, Borrello MT, Vellore NA, Ganesan A, Mattevi A, Baron R. Expanding the druggable space of the LSD1/CoREST epigenetic target: new potential binding regions for drug-like molecules, peptides, protein partners, and chromatin. Plos Computational Biology. 9: e1003158. PMID 23874194 DOI: 10.1371/Journal.Pcbi.1003158 |
0.742 |
|
| 2013 |
Tortorici M, Borrello MT, Tardugno M, Chiarelli LR, Pilotto S, Ciossani G, Vellore NA, Bailey SG, Cowan J, O'Connell M, Crabb SJ, Packham G, Mai A, Baron R, Ganesan A, et al. Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase. Acs Chemical Biology. 8: 1677-82. PMID 23721412 DOI: 10.1021/Cb4001926 |
0.755 |
|
| 2012 |
Crabb SJ, Hayden AL, Strivens RA, Benelkebir H, Ganesan A, Packham G. Biologic activity of LSD1 inhibition by novel tranylcypromine structural analogues in prostate cancer cells. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 30: 82. PMID 27968297 DOI: 10.1200/Jco.2012.30.5_Suppl.82 |
0.345 |
|
| 2012 |
Shaheen F, Rizvi TS, Musharraf SG, Ganesan A, Xiao K, Townsend JB, Lam KS, Choudhary MI. Solid-phase total synthesis of cherimolacyclopeptide E and discovery of more potent analogues by alanine screening. Journal of Natural Products. 75: 1882-7. PMID 23148652 DOI: 10.1021/Np300266E |
0.319 |
|
| 2012 |
Bonnet D, Margathe JF, Radford S, Pflimlin E, Riché S, Doman P, Hibert M, Ganesan A. Combinatorial aid for underprivileged scaffolds: solution and solid-phase strategies for a rapid and efficient access to novel aza-diketopiperazines (Aza-DKP). Acs Combinatorial Science. 14: 323-34. PMID 22458603 DOI: 10.1021/Co300015K |
0.317 |
|
| 2012 |
Davies ER, Haitchi HM, Thatcher TH, Sime PJ, Kottmann RM, Ganesan A, Packham G, O'Reilly KM, Davies DE. Spiruchostatin A inhibits proliferation and differentiation of fibroblasts from patients with pulmonary fibrosis. American Journal of Respiratory Cell and Molecular Biology. 46: 687-94. PMID 22246864 DOI: 10.1165/Rcmb.2011-0040Oc |
0.301 |
|
| 2011 |
Benelkebir H, Donlevy AM, Packham G, Ganesan A. Total synthesis and stereochemical assignment of burkholdac B, a depsipeptide HDAC inhibitor. Organic Letters. 13: 6334-7. PMID 22091906 DOI: 10.1021/Ol202197Q |
0.338 |
|
| 2011 |
Benelkebir H, Marie S, Hayden AL, Lyle J, Loadman PM, Crabb SJ, Packham G, Ganesan A. Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability. Bioorganic & Medicinal Chemistry. 19: 3650-8. PMID 21420302 DOI: 10.1016/J.Bmc.2011.02.024 |
0.32 |
|
| 2011 |
Benelkebir H, Hodgkinson C, Duriez PJ, Hayden AL, Bulleid RA, Crabb SJ, Packham G, Ganesan A. Enantioselective synthesis of tranylcypromine analogues as lysine demethylase (LSD1) inhibitors. Bioorganic & Medicinal Chemistry. 19: 3709-16. PMID 21382717 DOI: 10.1016/J.Bmc.2011.02.017 |
0.348 |
|
| 2009 |
Ganesan A, Nolan L, Crabb SJ, Packham G. Epigenetic Therapy: Histone Acetylation, DNA Methylation and Anti-Cancer Drug Discovery Current Cancer Drug Targets. 9: 963-981. PMID 20025605 DOI: 10.2174/156800909790192428 |
0.334 |
|
| 2009 |
Sharp A, Crabb SJ, Johnson PW, Hague A, Cutress R, Townsend PA, Ganesan A, Packham G. Thioflavin S (NSC71948) interferes with Bcl-2-associated athanogene (BAG-1)-mediated protein-protein interactions. The Journal of Pharmacology and Experimental Therapeutics. 331: 680-9. PMID 19690191 DOI: 10.1124/Jpet.109.153601 |
0.333 |
|
| 2009 |
Iijima Y, Munakata A, Shin-ya K, Ganesan A, Doi T, Takahashi T. A solid-phase total synthesis of the cyclic depsipeptide HDAC inhibitor spiruchostatin A Tetrahedron Letters. 50: 2970-2972. DOI: 10.1016/J.Tetlet.2009.04.005 |
0.343 |
|
| 2008 |
Wen S, Packham G, Ganesan A. Macrolactamization versus Macrolactonization: Total Synthesis of FK228, the Depsipeptide Histone Deacetylase Inhibitor† Journal of Organic Chemistry. 73: 9353-9361. PMID 18991384 DOI: 10.1021/Jo801866Z |
0.348 |
|
| 2008 |
Crabb SJ, Howell M, Rogers H, Ishfaq M, Yurek-George A, Carey K, Pickering BM, East P, Mitter R, Maeda S, Johnson PW, Townsend P, Shin-ya K, Yoshida M, Ganesan A, et al. Characterisation of the in vitro activity of the depsipeptide histone deacetylase inhibitor spiruchostatin A. Biochemical Pharmacology. 76: 463-75. PMID 18611394 DOI: 10.1016/J.Bcp.2008.06.004 |
0.384 |
|
| 2007 |
Yurek-George A, Cecil ARL, Mo AHK, Wen S, Rogers H, Habens F, Maeda S, Yoshida M, Packham G, Ganesan A. The first biologically active synthetic analogues of FK228, the depsipeptide histone deacetylase inhibitor. Journal of Medicinal Chemistry. 50: 5720-5726. PMID 17958342 DOI: 10.1021/Jm0703800 |
0.395 |
|
| 2007 |
Wen S, Carey KL, Nakao Y, Fusetani N, Packham G, Ganesan A. Total synthesis of azumamide A and azumamide E, evaluation as histone deacetylase inhibitors, and design of a more potent analogue. Organic Letters. 9: 1105-8. PMID 17311393 DOI: 10.1021/Ol070046Y |
0.379 |
|
| 2006 |
Nakao Y, Yoshida S, Matsunaga S, Shindoh N, Terada Y, Nagai K, Yamashita JK, Ganesan A, Soest RWMV, Fusetani N. Azumamides A–E: Histone Deacetylase Inhibitory Cyclic Tetrapeptides from the Marine Sponge Mycale izuensis Angewandte Chemie. 45: 7553-7557. PMID 16981208 DOI: 10.1002/Anie.200602047 |
0.304 |
|
| 2006 |
Ganesan A. Solid-Phase Synthesis in the Twenty-First Century Mini-Reviews in Medicinal Chemistry. 6: 3-10. PMID 16457628 DOI: 10.2174/138955706775197866 |
0.311 |
|
| 2006 |
Doi T, Iijima Y, Shin-ya K, Ganesan A, Takahashi T. A total synthesis of spiruchostatin A Tetrahedron Letters. 47: 1177-1180. DOI: 10.1016/J.Tetlet.2005.12.031 |
0.357 |
|
| 2006 |
Nakao Y, Yoshida S, Matsunaga S, Shindoh N, Terada Y, Nagai K, Yamashita JK, Ganesan A, van Soest RWM, Fusetani N, Izzo I, Maulucci N, Bifulco G, De Riccardis F. Cover Picture: Azumamides A–E: Histone Deacetylase Inhibitory Cyclic Tetrapeptides from the Marine SpongeMycale izuensis / Total Synthesis of Azumamides A and E Z602047 Z602033 (Angew. Chem. Int. Ed. 45/2006) Angewandte Chemie International Edition. 45: 7475-7475. DOI: 10.1002/Anie.200690154 |
0.31 |
|
| 2006 |
Nakao Y, Yoshida S, Matsunaga S, Shindoh N, Terada Y, Nagai K, Yamashita JK, Ganesan A, van Soest RWM, Fusetani N, Izzo I, Maulucci N, Bifulco G, De Riccardis F. Titelbild: Azumamides A–E: Histone Deacetylase Inhibitory Cyclic Tetrapeptides from the Marine SpongeMycale izuensis / Total Synthesis of Azumamides A and E (Angew. Chem. 45/2006) Angewandte Chemie. 118: 7637-7637. DOI: 10.1002/Ange.200690154 |
0.324 |
|
| 2005 |
Bourel-Bonnet L, Rao KV, Hamann MT, Ganesan A. Solid-phase total synthesis of kahalalide A and related analogues. Journal of Medicinal Chemistry. 48: 1330-5. PMID 15743176 DOI: 10.1021/Jm049841X |
0.321 |
|
| 2005 |
Davidson SM, Townsend PA, Carroll C, Yurek-George A, Balasubramanyam K, Kundu TK, Stephanou A, Packham G, Ganesan A, Latchman DS. The transcriptional coactivator p300 plays a critical role in the hypertrophic and protective pathways induced by phenylephrine in cardiac cells but is specific to the hypertrophic effect of urocortin Chembiochem. 6: 162-170. PMID 15593114 DOI: 10.1002/Cbic.200400246 |
0.348 |
|
| 2004 |
Yurek-George A, Habens F, Brimmell M, Packham G, Ganesan A. Total Synthesis of Spiruchostatin A, a Potent Histone Deacetylase Inhibitor Journal of the American Chemical Society. 126: 1030-1031. PMID 14746465 DOI: 10.1021/Ja039258Q |
0.398 |
|
| 2004 |
Boguszewski PA, Rahman SS, Ganesan A. Modular three-component solid-phase synthesis of unsymmetrical guanidines via resin capture of carbodiimides. Journal of Combinatorial Chemistry. 6: 32-4. PMID 14714980 DOI: 10.1021/Cc034036+ |
0.321 |
|
| 2004 |
Packham G, Yurek-George A, Habens F, Brimmell M, Ganesan A. Synthesis and analysis of spiruchostatin A, a potent bicyclic tetrapeptide histone deacetylase inhibitor British Journal of Cancer. DOI: 10.1038/Sj.Bjc.6601939 |
0.38 |
|
| 2003 |
Xiong Q, Zhu X, Wilson WK, Ganesan A, Matsuda SP. Enzymatic synthesis of an indole diterpene by an oxidosqualene cyclase: mechanistic, biosynthetic, and phylogenetic implications. Journal of the American Chemical Society. 125: 9002-3. PMID 15369342 DOI: 10.1021/Ja036322V |
0.315 |
|
| 2003 |
Ganesan A. Cyclative cleavage strategies for the solid-phase synthesis of heterocycles and natural products. Methods in Enzymology. 369: 415-434. PMID 14722966 DOI: 10.1016/S0076-6879(03)69022-1 |
0.333 |
|
| 2002 |
Ganesan A. Recent developments in combinatorial organic synthesis. Drug Discovery Today. 7: 47-55. DOI: 10.1016/S1359-6446(02)00002-8 |
0.315 |
|
| 2001 |
Ganesan A. Integrating natural product synthesis and combinatorial chemistry Pure and Applied Chemistry. 73: 1033-1039. DOI: 10.1351/Pac200173071033 |
0.311 |
|
| 2000 |
Wang H, Ganesan A. A biomimetic total synthesis of (-)-spirotryprostatin B and related studies. Journal of Organic Chemistry. 65: 4685-4693. PMID 10959875 DOI: 10.1021/Jo000306O |
0.316 |
|
| 2000 |
Wang H, Ganesan A. Total synthesis of the fumiquinazoline alkaloids: solution-phase studies. Journal of Organic Chemistry. 65: 1022-1030. PMID 10814050 DOI: 10.1021/Jo9914364 |
0.328 |
|
| 2000 |
Wang H, Usui T, Osada H, Ganesan A. Synthesis and evaluation of tryprostatin B and demethoxyfumitremorgin C analogues. Journal of Medicinal Chemistry. 43: 1577-85. PMID 10780915 DOI: 10.1021/Jm9905662 |
0.307 |
|
| 2000 |
Wang H, Ganesan A. Total synthesis of the fumiquinazoline alkaloids: solid-phase studies. Acs Combinatorial Science. 2: 186-194. PMID 10757098 DOI: 10.1021/Cc9900807 |
0.325 |
|
| 1999 |
and HW, Ganesan A. The N-Acyliminium Pictet−Spengler Condensation as a Multicomponent Combinatorial Reaction on Solid Phase and Its Application to the Synthesis of Demethoxyfumitremorgin C Analogues Organic Letters. 1: 1647-1649. DOI: 10.1021/Ol991030D |
0.307 |
|
| 1998 |
Li Z, Yeo SL, Pallen CJ, Ganesan A. Solid-phase synthesis of potential protein tyrosine phosphatase inhibitors via the Ugi four-component condensation Bioorganic & Medicinal Chemistry Letters. 8: 2443-2446. PMID 9873558 DOI: 10.1016/S0960-894X(98)00408-9 |
0.327 |
|
| 1998 |
Lin P, Ganesan A. Solid-phase synthesis of peptidomimetic oligomers with a phosphodiester backbone Bioorganic & Medicinal Chemistry Letters. 8: 511-514. PMID 9871608 DOI: 10.1016/S0960-894X(98)00064-X |
0.304 |
|
| 1998 |
Lin P, Ganesan A. Solid-phase synthesis of N-acyl-N′-carbamoylguanidines Tetrahedron Letters. 39: 9789-9792. DOI: 10.1016/S0040-4039(98)02174-1 |
0.316 |
|
| 1998 |
Wang H, Ganesan A. Total Synthesis Of The Cytotoxic Alkaloid Luotonin A Tetrahedron Letters. 39: 9097-9098. DOI: 10.1016/S0040-4039(98)02004-8 |
0.322 |
|
| 1998 |
Sim MM, Lee CL, Ganesan A. Solid-phase C-acylation of active methylene compounds Tetrahedron Letters. 39: 2195-2198. DOI: 10.1016/S0040-4039(98)00173-7 |
0.311 |
|
| 1997 |
Sim MM, Ganesan A. Solution-Phase Synthesis of a Combinatorial Thiohydantoin Library(1). Journal of Organic Chemistry. 62: 3230-3235. PMID 11671708 DOI: 10.1021/Jo962376U |
0.318 |
|
| 1997 |
Ellsmore VA, Teoh AP, Ganesan A. A High Throughput Enzyme-Linked Immunosorbent Assay for Inhibitors of the Interaction Between Retinoblastoma Protein and the Leu-X-Cys-X-Glu Motif Journal of Biomolecular Screening. 2: 207-211. DOI: 10.1177/108705719700200405 |
0.31 |
|
| 1997 |
Sim MM, Lee CL, Ganesan A. Combinatorial Synthesis of 2-Thioxo-4-dihydropyrimidinones Journal of Organic Chemistry. 62: 9358-9360. DOI: 10.1021/Jo971302V |
0.304 |
|
| 1997 |
Wang H, Ganesan A. Concise Synthesis Of The Cell Cycle Inhibitor Demethoxyfumitremorgin C Tetrahedron Letters. 38: 4327-4328. DOI: 10.1016/S0040-4039(97)00892-7 |
0.306 |
|
| 1997 |
Kulkarni BA, Ganesan A. Ion‐Exchange Resins for Combinatorial Synthesis: 2,4‐Pyrrolidinediones by Dieckmann Condensation Angewandte Chemie. 36: 2454-2455. DOI: 10.1002/Anie.199724541 |
0.307 |
|
| 1995 |
Schärer OD, Ortholand JY, Ganesan A, Ezaz-Nikpay K, Verdine GL. Specific binding of the DNA repair enzyme AlkA to a pyrrolidine-based inhibitor Journal of the American Chemical Society. 117: 6623-6624. DOI: 10.1021/Ja00129A039 |
0.527 |
|
| 1993 |
Ganesan A, Heathcock CH. Synthesis of unsymmetrical pyrazines by reaction of an oxadiazinone with enamines Journal of Organic Chemistry. 58: 6155-6157. DOI: 10.1021/Jo00074A058 |
0.48 |
|
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