Sarah M. Jacobo, Ph.D.

Affiliations: 
2008 Medicinal Chemistry and Molecular Pharmacology Purdue University, West Lafayette, IN, United States 
Area:
Physiology Biology, Cell Biology
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Greg Hockerman grad student 2008 Purdue
 (Dichotomy of calcium 1.2 and calcium 1.3 L-type calcium channel function and modulation in GLP-1-mediated insulin exocytosis and ERK1/2 activation in pancreatic beta-cells.)
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Publications

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Tian D, Jacobo SM, Billing D, et al. (2010) Antagonistic regulation of actin dynamics and cell motility by TRPC5 and TRPC6 channels. Science Signaling. 3: ra77
Jacobo SM, Guerra ML, Hockerman GH. (2009) Cav1.2 and Cav1.3 are differentially coupled to glucagon-like peptide-1 potentiation of glucose-stimulated insulin secretion in the pancreatic beta-cell line INS-1. The Journal of Pharmacology and Experimental Therapeutics. 331: 724-32
Jacobo SM, Guerra ML, Jarrard RE, et al. (2009) The intracellular II-III loops of Cav1.2 and Cav1.3 uncouple L-type voltage-gated Ca2+ channels from glucagon-like peptide-1 potentiation of insulin secretion in INS-1 cells via displacement from lipid rafts. The Journal of Pharmacology and Experimental Therapeutics. 330: 283-93
Liu G, Jacobo SM, Hilliard N, et al. (2006) Differential modulation of Cav1.2 and Cav1.3-mediated glucose-stimulated insulin secretion by cAMP in INS-1 cells: distinct roles for exchange protein directly activated by cAMP 2 (Epac2) and protein kinase A. The Journal of Pharmacology and Experimental Therapeutics. 318: 152-60
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