Stanislaw F. Wnuk - Publications

Affiliations: 
Florida International University, Miami, FL, United States 
Area:
Biochemistry, Organic Chemistry, Microbiology Biology

127 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Reyes Y, Mebel A, Wnuk SF. 6-azido and 6-azidomethyl uracil nucleosides. Nucleosides, Nucleotides & Nucleic Acids. 1-19. PMID 37859415 DOI: 10.1080/15257770.2023.2271023  0.317
2020 Mudgal M, Dang TP, Sobczak AJ, Lumpuy DA, Dutta P, Ward S, Ward K, Alahmadi M, Kumar A, Sevilla MD, Wnuk SF, Adhikary A. Site of Azido Substitution in the Sugar Moiety of Azidopyrimidine Nucleosides Influences the Reactivity of Aminyl Radicals Formed by Dissociative Electron Attachment. The Journal of Physical Chemistry. B. PMID 33270461 DOI: 10.1021/acs.jpcb.0c08201  0.664
2020 Suzol SH, Hasan Howlader A, Galván AE, Radhakrishnan M, Wnuk SF, Rosen BP, Yoshinaga M. Semisynthesis of the Organoarsenical Antibiotic Arsinothricin. Journal of Natural Products. PMID 32830503 DOI: 10.1021/Acs.Jnatprod.0C00522  0.313
2020 Zhao L, Kaiser RI, Lu W, Ahmed M, Oleinikov AD, Azyazov VN, Mebel AM, Howlader AH, Wnuk SF. Gas phase formation of phenalene via 10π-aromatic, resonantly stabilized free radical intermediates. Physical Chemistry Chemical Physics : Pccp. PMID 32598423 DOI: 10.1039/D0Cp02216K  0.307
2020 Wnuk SF, Mudgal MM, Nowak I, Robins MJ. Model Substrate/Inactivation Reactions for MoaA and Ribonucleotide Reductases: Loss of Bromo, Chloro, or Tosylate Groups from C2 of 1,5-Dideoxyhomoribofuranoses upon Generation of an α-Oxy Radical at C3. Molecules (Basel, Switzerland). 25. PMID 32486052 DOI: 10.3390/Molecules25112539  0.432
2020 Howlader AH, Diaz K, Mebel AM, Kaiser RI, Wnuk SF. Iodoindenes: Synthesis and application to cross-coupling Tetrahedron Letters. 61: 152427. DOI: 10.1016/J.Tetlet.2020.152427  0.421
2019 Zhao L, Kaiser RI, Lu W, Xu B, Ahmed M, Morozov AN, Mebel AM, Howlader AH, Wnuk SF. Molecular mass growth through ring expansion in polycyclic aromatic hydrocarbons via radical-radical reactions. Nature Communications. 10: 3689. PMID 31417088 DOI: 10.1038/S41467-019-11652-5  0.338
2019 Zhao L, Prendergast M, Kaiser RI, Xu B, Ablikim U, Lu W, Ahmed M, Oleinikov AD, Azyazov VN, Howlader AH, Wnuk SF, Mebel AM. How to add a five-membered ring to polycyclic aromatic hydrocarbons (PAHs) - molecular mass growth of the 2-naphthyl radical (CH) to benzindenes (CH) as a case study. Physical Chemistry Chemical Physics : Pccp. PMID 31322639 DOI: 10.1039/C9Cp02930C  0.33
2019 Zhao L, Kaiser RI, Xu B, Ablikim U, Lu W, Ahmed M, Evseev MM, Bashkirov EK, Azyazov VN, Zagidullin MV, Morozov AN, Howlader AH, Wnuk SF, Mebel AM, Joshi D, et al. Gas phase synthesis of [4]-helicene. Nature Communications. 10: 1510. PMID 30944302 DOI: 10.1038/S41467-019-09224-8  0.335
2019 Zhao L, Prendergast MB, Kaiser RI, Xu B, Lu W, Ablikim U, Ahmed M, Oleinikov AD, Azyazov VN, Mebel AM, Howlader AH, Wnuk SF. Reactivity of the Indenyl Radical (C₉H₇) with Acetylene (C₂H₂) and Vinylacetylene (C₄H₄). Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. PMID 30938059 DOI: 10.1002/Cphc.201900052  0.386
2019 Wen Z, Tuttle PR, Howlader AH, Vasilyeva A, Gonzales L, Tangar A, Lei R, Laverde EE, Liu Y, Miksovska J, Wnuk SF. Fluorescent 5-Pyrimidine and 8-Purine Nucleosides Modified with N-unsubstituted 1,2,3-Triazol-4-yl Moiety. The Journal of Organic Chemistry. PMID 30806513 DOI: 10.1021/Acs.Joc.8B03135  0.339
2019 Zhao L, Xu B, Ablikim U, Lu W, Ahmed M, Evseev MM, Bashkirov EK, Azyazov VN, Howlader AH, Wnuk SF, Mebel AM, Kaiser RI. Gas Phase Synthesis of Triphenylene (C₁₈H₁₂). Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. PMID 30710434 DOI: 10.1002/Cphc.201801154  0.326
2019 Zhao L, Xu B, Ablikim U, Lu W, Ahmed M, Evseev MM, Bashkirov EK, Azyazov VN, Howlader AH, Wnuk SF, Mebel AM, Kaiser RI. Front Cover: Gas‐Phase Synthesis of Triphenylene (C 18 H 12 ) (ChemPhysChem 6/2019) Chemphyschem. 20: 785-785. DOI: 10.1002/Cphc.201900201  0.311
2018 Wen Z, Peng J, Tuttle PR, Ren Y, Garcia C, Debnath D, Rishi S, Hanson C, Ward S, Kumar A, Liu Y, Zhao W, Glazer PM, Liu Y, Sevilla MD, ... ... Wnuk SF, et al. Electron-Mediated Aminyl and Iminyl Radicals from C5 Azido-Modified Pyrimidine Nucleosides Augment Radiation Damage to Cancer Cells. Organic Letters. PMID 30457873 DOI: 10.1021/Acs.Orglett.8B03035  0.353
2018 Gonzalez C, de Cabrera M, Wnuk SF. Gemcitabine analogues with 4-N-alkyl chain modified with fluoromethyl ketone group. Nucleosides, Nucleotides & Nucleic Acids. 1-13. PMID 29750577 DOI: 10.1080/15257770.2018.1465186  0.373
2018 Gonzalez C, Sanchez A, Collins J, Lisova K, Lee JT, Michael van Dam R, Alejandro Barbieri M, Ramachandran C, Wnuk SF. The 4-N-acyl and 4-N-alkyl gemcitabine analogues with silicon-fluoride-acceptor: Application toF-Radiolabeling. European Journal of Medicinal Chemistry. 148: 314-324. PMID 29471120 DOI: 10.1016/J.Ejmech.2018.02.017  0.328
2017 Mudgal M, Rishi S, Lumpuy DA, Curran KA, Verley KL, Sobczak AJ, Dang TP, Sulimoff N, Kumar A, Sevilla MD, Wnuk SF, Adhikary A. Prehydrated One-Electron Attachment to Azido-Modified Pentafuranoses: Aminyl Radical Formation, Rapid H-Atom Transfer and Subsequent Ring Opening. The Journal of Physical Chemistry. B. PMID 28425714 DOI: 10.1021/Acs.Jpcb.7B01838  0.723
2017 Wen Z, Suzol SH, Peng J, Liang Y, Snoeck R, Andrei G, Liekens S, Wnuk SF. Antiviral and Cytostatic Evaluation of 5-(1-Halo-2-sulfonylvinyl)- and 5-(2-Furyl)uracil Nucleosides. Archiv Der Pharmazie. PMID 28304114 DOI: 10.1002/Ardp.201700023  0.348
2016 Kavoosi S, Rayala R, Walsh B, Barrios M, Gonzalez WG, Miksovska J, Mathivathanan L, Raptis RG, Wnuk SF. Synthesis of 8-(1,2,3-triazol-1-yl)-7-deazapurine nucleosides by azide-alkyne click reactions and direct C-H bond functionalization. Tetrahedron Letters. 57: 4364-4367. PMID 28239199 DOI: 10.1016/J.Tetlet.2016.08.053  0.425
2016 He Q, Wang L, Liang Y, Zhang Z, Wnuk SF. Transition-metal-free cross-coupling of aryl halides with arylstannanes. The Journal of Organic Chemistry. PMID 27571510 DOI: 10.1021/Acs.Joc.6B01648  0.386
2016 Chbib C, Sobczak AJ, Mudgal M, Gonzalez C, Lumpuy D, Nagaj J, Stokowa-Soltys K, Wnuk SF. S-Ribosylhomocysteine Analogues Modified at the Ribosyl C-4 Position. Journal of Sulphur Chemistry. 37: 307-327. PMID 27516805 DOI: 10.1080/17415993.2015.1137921  0.793
2016 Gonzalez C, Kavoosi S, Sanchez A, Wnuk SF. Reduction of sugar lactones to hemiacetals with lithium triethylborohydride. Carbohydrate Research. 432: 17-22. PMID 27341397 DOI: 10.1016/J.Carres.2016.06.002  0.384
2016 Rayala R, Giuglio-Tonolo A, Broggi J, Terme T, Vanelle P, Theard P, Médebielle M, Wnuk SF. Studies toward the oxidative and reductive activation of C-S bonds in 2'-S-aryl-2'-thiouridine derivatives. Tetrahedron. 72: 1969-1977. PMID 27019535 DOI: 10.1016/J.Tet.2016.02.063  0.438
2016 Liang Y, Suzol SH, Wen Z, Artiles AG, Mathivathanan L, Raptis RG, Wnuk SF. Uracil Nucleosides with Reactive Group at C5 Position: 5-(1-Halo-2-sulfonylvinyl)uridine Analogues. Organic Letters. PMID 26933954 DOI: 10.1021/Acs.Orglett.6B00346  0.364
2016 Chbib C, Sobczak AJ, Mudgal M, Gonzalez C, Lumpuy D, Nagaj J, Stokowa-Soltys K, Wnuk SF. S-Ribosylhomocysteine analogues modified at the ribosyl C-4 position Journal of Sulfur Chemistry. 1-21. DOI: 10.1080/17415993.2015.1137921  0.784
2016 Kavoosi S, Rayala R, Walsh B, Barrios M, Gonzalez WG, Miksovska J, Mathivathanan L, Raptis RG, Wnuk SF. Synthesis of 8-(1,2,3-triazol-1-yl)-7-deazapurine nucleosides by azide–alkyne click reactions and direct C[sbnd]H bond functionalization Tetrahedron Letters. 57: 4364-4367. DOI: 10.1016/j.tetlet.2016.08.053  0.314
2015 Sobczak AJ, Chbib C, Wnuk SF. S-Ribosylhomocysteine analogs containing a [4-thio]ribose ring. Carbohydrate Research. 415: 39-47. PMID 26279525 DOI: 10.1016/J.Carres.2015.07.005  0.786
2015 Zayas J, Annoual M, Das JK, Felty Q, Gonzalez WG, Miksovska J, Sharifai N, Chiba A, Wnuk SF. Strain Promoted Click Chemistry of 2- or 8-Azidopurine and 5-Azidopyrimidine Nucleosides and 8-Azidoadenosine Triphosphate with Cyclooctynes. Application to Living Cell Fluorescent Imaging. Bioconjugate Chemistry. 26: 1519-32. PMID 26086070 DOI: 10.1021/Acs.Bioconjchem.5B00300  0.321
2015 Liang Y, Wnuk SF. Modification of purine and pyrimidine nucleosides by direct C-H bond activation. Molecules (Basel, Switzerland). 20: 4874-901. PMID 25789821 DOI: 10.3390/Molecules20034874  0.415
2014 Adhikary A, Kumar A, Rayala R, Hindi RM, Adhikary A, Wnuk SF, Sevilla MD. One-electron oxidation of gemcitabine and analogs: mechanism of formation of C3' and C2' sugar radicals. Journal of the American Chemical Society. 136: 15646-53. PMID 25296262 DOI: 10.1021/Ja5083156  0.351
2014 Rayala R, Theard P, Ortiz H, Yao S, Young JD, Balzarini J, Robins MJ, Wnuk SF. Synthesis of purine and 7-deazapurine nucleoside analogues of 6-N-(4-Nitrobenzyl)adenosine; inhibition of nucleoside transport and proliferation of cancer cells. Chemmedchem. 9: 2186-92. PMID 24788480 DOI: 10.1002/Cmdc.201402047  0.317
2014 Liang Y, Gloudeman J, Wnuk SF. Palladium-catalyzed direct arylation of 5-halouracils and 5-halouracil nucleosides with arenes and heteroarenes promoted by TBAF. The Journal of Organic Chemistry. 79: 4094-103. PMID 24724921 DOI: 10.1021/Jo500602P  0.454
2014 Pulido J, Sobczak AJ, Balzarini J, Wnuk SF. Synthesis and cytostatic evaluation of 4-N-alkanoyl and 4-N-alkyl gemcitabine analogues. Journal of Medicinal Chemistry. 57: 191-203. PMID 24341356 DOI: 10.1021/Jm401586A  0.347
2013 Liang Y, Pitteloud JP, Wnuk SF. Hydrogermylation of 5-ethynyluracil nucleosides: formation of 5-(2-germylvinyl)uracil and 5-(2-germylacetyl)uracil nucleosides. The Journal of Organic Chemistry. 78: 5761-7. PMID 23631719 DOI: 10.1021/Jo400590Z  0.741
2013 Adhikary A, Kumar A, Heizer AN, Palmer BJ, Pottiboyina V, Liang Y, Wnuk SF, Sevilla MD. Hydroxyl ion addition to one-electron oxidized thymine: unimolecular interconversion of C5 to C6 OH-adducts. Journal of the American Chemical Society. 135: 3121-35. PMID 23362972 DOI: 10.1021/Ja310650N  0.303
2013 Zhu M, Zhang Z, Xue D, Qiao J, Liang Y, Wnuk SF. Synthesis of 5,6-Diarylpyridin-2(1H)-ones from Isoflavones Chinese Journal of Chemistry. 31: 1027-1032. DOI: 10.1002/Cjoc.201300279  0.311
2012 Rayala R, Wnuk SF. Bromination at C-5 of Pyrimidine and C-8 of Purine Nucleosides with 1,3-Dibromo-5,5-dimethylhydantoin. Tetrahedron Letters. 53: 3333-3336. PMID 22773864 DOI: 10.1016/J.Tetlet.2012.04.081  0.375
2012 Dang TP, Sobczak AJ, Mebel AM, Chatgilialoglu C, Wnuk SF. Investigation of reactions postulated to occur during inhibition of ribonucleotide reductases by 2'-azido-2'-deoxynucleotides. Tetrahedron. 68: 5655-5667. PMID 22711937 DOI: 10.1016/J.Tet.2012.04.050  0.714
2012 Shokar A, Au A, An SH, Tong E, Garza G, Zayas J, Wnuk SF, Land KM. S-Adenosylhomocysteine hydrolase of the protozoan parasite Trichomonas vaginalis: potent inhibitory activity of 9-(2-deoxy-2-fluoro-β,D-arabinofuranosyl)adenine. Bioorganic & Medicinal Chemistry Letters. 22: 4203-5. PMID 22579483 DOI: 10.1016/J.Bmcl.2012.03.087  0.31
2012 Pitteloud J, Liang Y, Wnuk SF. ChemInform Abstract: Chemoselective Transfer of Allyl or Phenyl Group from Allyl(phenyl)germanes in Pd-Catalyzed Reactions with Aryl Halides. Cheminform. 43: no-no. DOI: 10.1002/CHIN.201208048  0.719
2011 Malladi VLA, Sobczak AJ, Meyer TM, Pei D, Wnuk SF. Inhibition of LuxS by S-ribosylhomocysteine analogues containing a [4-aza]ribose ring Bioorganic and Medicinal Chemistry. 19: 5507-5519. PMID 21855358 DOI: 10.1016/J.Bmc.2011.07.043  0.693
2011 Malladi VL, Sobczak AJ, Maricic N, Murugapiran SK, Schneper L, Makemson J, Mathee K, Wnuk SF. Substituted lactam and cyclic azahemiacetals modulate Pseudomonas aeruginosa quorum sensing. Bioorganic & Medicinal Chemistry. 19: 5500-6. PMID 21855349 DOI: 10.1016/J.Bmc.2011.07.044  0.665
2011 Wnuk SF, Penjarla JAK, Dang T, Mebel AM, Nauser T, Schöneich C. Modeling of the ribonucleotide reductases substrate reaction. Hydrogen atom abstraction by a thiyl free radical and detection of the ribosyl-based carbon radical by pulse radiolysis Collection of Czechoslovak Chemical Communications. 76: 1223-1238. DOI: 10.1135/Cccc2011085  0.7
2010 Pitteloud JP, Zhang ZT, Liang Y, Cabrera L, Wnuk SF. Fluoride-promoted cross-coupling of chloro(mono-, di-, or triphenyl)germanes with aryl halides in "moist" toluene. Multiple transfer of the phenyl group from organogermane substrates and comparison of the coupling efficiencies of chloro(phenyl)germanes with their corresponding stannane and silane counterparts. The Journal of Organic Chemistry. 75: 8199-212. PMID 21067173 DOI: 10.1021/Jo101848F  0.727
2010 Dornbush PJ, Vazquez-Anaya G, Shokar A, Benson S, Rapp M, Wnuk SF, Wrischnik LA, Land KM. AdoHcy hydrolase of Trichomonas vaginalis: studies of the effects of 5'-modified adenosine analogues and related 6-N-cyclopropyl derivatives. Bioorganic & Medicinal Chemistry Letters. 20: 7466-8. PMID 21044841 DOI: 10.1016/J.Bmcl.2010.10.014  0.316
2010 Zhang ZT, Pitteloud JP, Cabrera L, Liang Y, Toribio M, Wnuk SF. Arylchlorogermanes/TBAF/"moist" toluene: a promising combination for Pd-catalyzed Germyl-Stille cross-coupling. Organic Letters. 12: 816-9. PMID 20092358 DOI: 10.1021/Ol9028918  0.729
2010 Zhang Z, Pitteloud J, Cabrera L, Liang Y, Toribio M, Wnuk SF. ChemInform Abstract: Arylchlorogermanes/TBAF/“Moist” Toluene: A Promising Combination for Pd-Catalyzed Germyl-Stille Cross-Coupling. Cheminform. 41: no-no. DOI: 10.1002/CHIN.201027084  0.699
2010 Wnuk SF, Valdez CA, Valdez NX. ChemInform Abstract: Rhodium(I)-Catalyzed Regio- and Stereoselective Chloroesterification of Furanose-Derived Terminal Alkynes with Ethyl Chloroformate. Cheminform. 32: no-no. DOI: 10.1002/chin.200131203  0.316
2009 Wnuk SF, Sacasa PR, Restrepo J. Application of germyldesulfonylation reactions to the synthesis of germanium-containing nucleoside analogues. Nucleosides, Nucleotides & Nucleic Acids. 28: 537-49. PMID 20183601 DOI: 10.1080/15257770903054340  0.781
2009 Sacasa PR, Zayas J, Wnuk SF. Radical-mediated thiodesulfonylation of the vinyl sulfones: Access to (α-fluoro)vinyl sulfides. Tetrahedron Letters. 50: 5424-5427. PMID 20161068 DOI: 10.1016/J.Tetlet.2009.07.063  0.772
2009 Rapp M, Cai X, Xu W, Dolbier WR, Wnuk SF. Reactions of Trimethylsilyl Fluorosulfonyldifluoroacetate with Purine and Pyrimidine Nucleosides. Journal of Fluorine Chemistry. 130: 321-328. PMID 20160856 DOI: 10.1016/J.Jfluchem.2008.12.004  0.433
2009 Wnuk SF, Robert J, Sobczak AJ, Meyers BP, Malladi VL, Zhu J, Gopishetty B, Pei D. Inhibition of S-ribosylhomocysteinase (LuxS) by substrate analogues modified at the ribosyl C-3 position. Bioorganic & Medicinal Chemistry. 17: 6699-706. PMID 19682914 DOI: 10.1016/J.Bmc.2009.07.057  0.699
2009 Zipse H, Artin E, Wnuk S, Lohman GJ, Martino D, Griffin RG, Kacprzak S, Kaupp M, Hoffman B, Bennati M, Stubbe J, Lees N. Structure of the nucleotide radical formed during reaction of CDP/TTP with the E441Q-alpha2beta2 of E. coli ribonucleotide reductase. Journal of the American Chemical Society. 131: 200-11. PMID 19128178 DOI: 10.1021/Ja806693S  0.346
2009 Gopishetty B, Zhu J, Rajan R, Sobczak AJ, Wnuk SF, Bell CE, Pei D. Probing the catalytic mechanism of S-ribosylhomocysteinase (LuxS) with catalytic intermediates and substrate analogues. Journal of the American Chemical Society. 131: 1243-50. PMID 19099445 DOI: 10.1021/Ja808206W  0.442
2008 Wang Z, Pitteloud JP, Montes L, Rapp M, Derane D, Wnuk SF. Vinyl Tris(trimethylsilyl)silanes: Substrates for Hiyama Coupling. Tetrahedron. 64: 5322-5327. PMID 19478830 DOI: 10.1016/J.Tet.2008.03.024  0.774
2008 Wnuk SF, Sacasa PR, Lewandowska E, Andrei D, Cai S, Borchardt RT. Synthesis of 5'-functionalized nucleosides: S-Adenosylhomocysteine analogues with the carbon-5' and sulfur atoms replaced by a vinyl or halovinyl unit. Bioorganic & Medicinal Chemistry. 16: 5424-33. PMID 18457953 DOI: 10.1016/J.Bmc.2008.04.017  0.792
2008 Wnuk SF, Lalama J, Garmendia CA, Robert J, Zhu J, Pei D. S-Ribosylhomocysteine analogues with the carbon-5 and sulfur atoms replaced by a vinyl or (fluoro)vinyl unit. Bioorganic & Medicinal Chemistry. 16: 5090-102. PMID 18375129 DOI: 10.1016/J.Bmc.2008.03.028  0.394
2007 Wnuk SF, Lalama J, Robert J, Garmendia CA. Novel S-ribosylhomocysteine analogues as potential inhibitors of LuxS enzyme. Nucleosides, Nucleotides & Nucleic Acids. 26: 1051-5. PMID 18058535 DOI: 10.1080/15257770701513190  0.377
2007 Robins MJ, Nowak I, Wnuk SF, Hansske F, Madej D. Deoxygenative [1,2]-hydride shift rearrangements in nucleoside and sugar chemistry: analogy with the [1,2]-electron shift in the deoxygenation of ribonucleotides by ribonucleotide reductases. The Journal of Organic Chemistry. 72: 8216-21. PMID 17918996 DOI: 10.1021/Jo071102B  0.343
2006 Xu W, Abboud KA, Ghiviriga I, Dolbier WR, Rapp M, Wnuk SF. An unexpected reaction of trimethylsilyl fluorosulfonyldifluoroacetate (TFDA) with imidazoles. Formation of N-difluoromethylthioureas. Organic Letters. 8: 5549-51. PMID 17107069 DOI: 10.1021/Ol062213K  0.329
2006 Andrei D, Wnuk SF. S-adenosylhomocysteine analogues with the carbon-5' and sulfur atoms replaced by a vinyl unit. Organic Letters. 8: 5093-6. PMID 17048851 DOI: 10.1021/Ol062026M  0.676
2006 Rapp M, Haubrich TA, Perrault J, Mackey ZB, McKerrow JH, Chiang PK, Wnuk SF. Antitrypanosomal activity of 5'-deoxy-5'-(iodomethylene)adenosine and related 6-N-cyclopropyladenosine analogues. Journal of Medicinal Chemistry. 49: 2096-102. PMID 16539398 DOI: 10.1021/Jm0511379  0.355
2006 Andrei D, Wnuk SF. Synthesis of the multisubstituted halogenated olefins via cross-coupling of dihaloalkenes with alkylzinc bromides. The Journal of Organic Chemistry. 71: 405-8. PMID 16388671 DOI: 10.1021/Jo051980E  0.684
2005 Robins MJ, Wnuk SF. Reduction of ribonucleosides to 2'-deoxyribonucleosides. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. Unit 1.11. PMID 18428933 DOI: 10.1002/0471142700.Nc0111S21  0.404
2005 Fritscher J, Artin E, Wnuk S, Bar G, Robblee JH, Kacprzak S, Kaupp M, Griffin RG, Bennati M, Stubbe J. Structure of the nitrogen-centered radical formed during inactivation of E. coli ribonucleotide reductase by 2'-azido-2'-deoxyuridine-5'-diphosphate: trapping of the 3'-ketonucleotide. Journal of the American Chemical Society. 127: 7729-38. PMID 15913363 DOI: 10.1021/Ja043111X  0.301
2005 Wang M, Zhang J, Andrei D, Kuczera K, Borchardt RT, Wnuk SF. Are L-adenosine and its derivatives substrates for S-adenosyl-L-homocysteine hydrolase? Journal of Medicinal Chemistry. 48: 3649-53. PMID 15887973 DOI: 10.1021/Jm0490484  0.629
2005 Wang Z, Wnuk SF. Application of vinyl tris(trimethylsilyl)germanes in Pd-catalyzed couplings. The Journal of Organic Chemistry. 70: 3281-4. PMID 15822995 DOI: 10.1021/Jo047773G  0.603
2005 Wang Z, Gonzalez A, Wnuk SF. Pd-Catalyzed Couplings of (α-Fluoro)vinyl Tris(trimethylsilyl)germanes. Cheminform. 36. DOI: 10.1016/J.Tetlet.2005.06.023  0.586
2004 Wnuk SF, Lewandowska E, Sacasa PR, Crain LN, Zhang J, Borchardt RT, De Clercq E. Stereoselective synthesis of sugar-modified enyne analogues of adenosine and uridine. Interaction with S-adenosyl-L-homocysteine hydrolase and antiviral and cytotoxic effects. Journal of Medicinal Chemistry. 47: 5251-7. PMID 15456269 DOI: 10.1021/Jm040054+  0.762
2004 Wnuk SF, Garcia PI, Wang Z. Radical-mediated silyl- and germyldesulfonylation of vinyl and (alpha-fluoro)vinyl sulfones: application of tris(trimethylsilyl)silanes and tris(trimethylsilyl)germanes in Pd-catalyzed couplings. Organic Letters. 6: 2047-9. PMID 15176815 DOI: 10.1021/Ol049312N  0.581
2004 Wnuk SF, Lewandowska E, Companioni DR, Garcia PI, Secrist JA. Synthesis and cytotoxicity of 9-(2-deoxy-2-alkyldithio-beta-D-arabinofuranosyl)purine nucleosides which are stable precursors to potential mechanistic probes of ribonucleotide reductases. Organic & Biomolecular Chemistry. 2: 120-6. PMID 14737670 DOI: 10.1039/B311504F  0.315
2004 Chatfield D, Augsten A, D'Cunha C, Lewandowska E, Wnuk S. Theoretical and Experimental Study of the Regioselectivity of Michael Additions European Journal of Organic Chemistry. 2004: 313-322. DOI: 10.1002/Ejoc.200300523  0.339
2003 Wnuk SF, Sacasa PR, Crain LN, Lewandowska E, Zhang J, Borchardt RT. Stereocontrolled synthesis of diene and enyne sugar-modified nucleosides and their interaction with S-adenosyl-L-homocysteine hydrolase. Nucleosides, Nucleotides & Nucleic Acids. 22: 783-5. PMID 14565278 DOI: 10.1081/Ncn-120022634  0.796
2003 Lewandowska E, Lalama J, Yuan CS, Wnuk SF. Open-chain carbocyclic analogs of adenosine with dihalovinyl unit as potential inhibitors of S-adenosyl-L-homocysteine hydrolase. Nucleosides, Nucleotides & Nucleic Acids. 22: 1747-55. PMID 14533879 DOI: 10.1081/Ncn-120023270  0.384
2002 Wnuk SF, Companioni DR, Neschadimenko V, Robins MJ. The beta-fluorine effect. Electronic versus steric effects in radical deoxygenations of fluorine-containing pentofuranose nucleosides. The Journal of Organic Chemistry. 67: 8794-7. PMID 12467391 DOI: 10.1021/Jo020428B  0.339
2002 Wnuk SF. Targeting "hydrolytic" activity of the S-adenosyl-L-homocysteine hydrolase. Mini Reviews in Medicinal Chemistry. 1: 307-16. PMID 12369977 DOI: 10.2174/1389557013406918  0.347
2002 Wnuk SF, Ro BO, Valdez CA, Lewandowska E, Valdez NX, Sacasa PR, Yin D, Zhang J, Borchardt RT, De Clercq E. Sugar-modified conjugated diene analogues of adenosine and uridine: synthesis, interaction with S-adenosyl-L-homocysteine hydrolase, and antiviral and cytostatic effects. Journal of Medicinal Chemistry. 45: 2651-8. PMID 12036374 DOI: 10.1021/Jm020064F  0.766
2002 Wnuk SF, Bergolla LA, Garcia PI. Studies toward the synthesis of alpha-fluorinated phosphonates via tin-mediated cleavage of alpha-fluoro-alpha-(pyrimidin-2-ylsulfonyl)alkylphosphonates. Intramolecular cyclization of the alpha-phosphonyl radicals. The Journal of Organic Chemistry. 67: 3065-71. PMID 11975568 DOI: 10.1021/Jo0111560  0.307
2002 Lewandowska E, Kinastowski S, Wnuk SF. Studies on the rearrangement of ortho-nitrobenzylidenemalonates and their Analogues to 2-aminobenzoate derivatives Canadian Journal of Chemistry. 80: 192-199. DOI: 10.1139/V02-010  0.418
2001 Wnuk SF, Valdez CA, Valdez NX. Rhodium(I)-catalyzed regio- and stereoselective chloroesterification of furanose-derived terminal alkynes with ethyl chloroformate Journal of Carbohydrate Chemistry. 20: 71-79. DOI: 10.1081/Car-100102544  0.419
2000 Yang X, Yin D, Wnuk SF, Robins MJ, Borchardt RT. Mechanisms of inactivation of human S-adenosylhomocysteine hydrolase by 5',5',6',6'-tetradehydro-6'-deoxy-6'-halohomoadenosines. Biochemistry. 39: 15234-41. PMID 11106503 DOI: 10.1021/Bi0015055  0.361
2000 Wnuk SF, Rios JM, Khan J, Hsu YL. Stannyl radical-mediated cleavage of pi-deficient heterocyclic sulfones. Synthesis Of alpha-fluoro esters The Journal of Organic Chemistry. 65: 4169-74. PMID 10866636 DOI: 10.1021/Jo000342N  0.436
2000 Wnuk SF, Valdez CA, Khan J, Moutinho P, Robins MJ, Yang X, Borchardt RT, Balzarini J, De Clercq E. Doubly homologated dihalovinyl and acetylene analogues of adenosine: synthesis, interaction with S-adenosyl-L-homocysteine hydrolase, and antiviral and cytostatic effects. Journal of Medicinal Chemistry. 43: 1180-6. PMID 10737751 DOI: 10.1021/Jm990486Y  0.415
2000 Wnuk SF, Lewandowska E, Valdez CA, Kinastowski S. Rearrangement of Nitropyridylidenemalonate 1-Oxides. A Novel Method for the Synthesis of Aminopyridine Derivatives Tetrahedron. 56: 7667-7671. DOI: 10.1016/S0040-4020(00)00693-1  0.367
1999 Giziewicz J, Wnuk SF, Robins MJ. Nucleic Acid Related Compounds. 107. Efficient Nitration of Uracil Base and Nucleoside Derivatives(1). The Journal of Organic Chemistry. 64: 2149-2151. PMID 11674318 DOI: 10.1021/Jo9822939  0.307
1999 Wnuk SF, Yuan CS, Borchardt RT, Robins MJ. Design and biological evaluation of new mechanism-based inhibitors of S- adenosyl-L-homocysteine hydrolase Nucleosides and Nucleotides. 18: 595-596. DOI: 10.1080/15257779908041506  0.329
1999 Robins MJ, Guo Z, Samano MC, Wnuk SF. Biomimetic simulation of free radical-initiated cascade reactions postulated to occur at the active site of ribonucleotide reductases Journal of the American Chemical Society. 121: X-1432. DOI: 10.1021/Ja983449P  0.368
1999 Guo Z, Samano MC, Krzykawski JW, Wnuk SF, Ewing GJ, Robins MJ. Biomimetic modeling of the abstraction of H3' by ribonucleotide reductases. 1,5-Hydrogen atom transfer of H3 to aminyl and oxyl, but not thlyl, free radicals in homoribofuranose derivatives Tetrahedron. 55: 5705-5718. DOI: 10.1016/S0040-4020(99)00238-0  0.412
1998 Robins MJ, Lewandowska E, Wnuk SF. Nucleic Acid Related Compounds. 105. Synthesis of 2',3'-Didehydro-2',3'-dideoxynucleosides from Ribonucleoside Cyclic 2',3'-(Sulfates or Phosphates) or 2',3'-Dimesylates via Reductive Elimination with Sodium Naphthalenide(1). The Journal of Organic Chemistry. 63: 7375-7381. PMID 11672386 DOI: 10.1021/Jo981013M  0.428
1998 Robins MJ, Wnuk SF, Yang X, Yuan CS, Borchardt RT, Balzarini J, De Clercq E. Inactivation of S-adenosyl-L-homocysteine hydrolase and antiviral activity with 5',5',6',6'-tetradehydro-6'-deoxy-6'-halohomoadenosine analogues (4'-haloacetylene analogues derived from adenosine). Journal of Medicinal Chemistry. 41: 3857-64. PMID 9748360 DOI: 10.1021/Jm980163M  0.437
1998 Wnuk SF, Yuan CS, Borchardt RT, Robins MJ. Synthesis of homologated halovinyl derivatives from aristeromycin and their inhibition of human placental S-adenosyl-L-homocysteine hydrolase. Nucleosides & Nucleotides. 17: 99-113. PMID 9708344 DOI: 10.1080/07328319808005161  0.417
1998 Wnuk SF, Mao Y, Yuan CS, Borchardt RT, Andrei G, Balzarini J, De Clercq E, Robins MJ. Discovery of type II (covalent) inactivation of S-adenosyl-L-homocysteine hydrolase involving its "hydrolytic activity": synthesis and evaluation of dihalohomovinyl nucleoside analogues derived from adenosine. Journal of Medicinal Chemistry. 41: 3078-83. PMID 9685247 DOI: 10.1021/Jm9801410  0.395
1998 Yuan CS, Wnuk SF, Robins MJ, Borchardt RT. A novel mechanism-based inhibitor (6'-bromo-5', 6'-didehydro-6'-deoxy-6'-fluorohomoadenosine) that covalently modifies human placental S-adenosylhomocysteine hydrolase. The Journal of Biological Chemistry. 273: 18191-7. PMID 9660780 DOI: 10.1074/Jbc.273.29.18191  0.319
1998 Robins MJ, Neschadimenko V, Ro B, Yuan C, Borchardt RT, Wnuk SF. Nucleic Acid Related Compounds. 101.S-Adenosyl-l-homocysteine Hydrolase Does Not Hydrate (5‘-Fluoro)vinyl or (6‘-Halo)homovinyl Analogues Derived from 3‘-Deoxyadenosine or 3‘-(Chloro or Fluoro)-3‘-deoxyadenosine1 Journal of Organic Chemistry. 63: 1205-1211. DOI: 10.1021/Jo971741U  0.4
1997 Huang H, Yuan CS, Wnuk SF, Robins MJ, Borchardt RT. The mechanism of inactivation of human placental S-adenosylhomocysteine hydrolase by (E)-4',5'-didehydro-5'-methoxyadenosine and adenosine 5'-carboxaldehyde oxime. Archives of Biochemistry and Biophysics. 343: 109-17. PMID 9210652 DOI: 10.1006/Abbi.1997.0159  0.313
1997 Wnuk SF, Yuan CS, Borchardt RT, Balzarini J, De Clercq E, Robins MJ. Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues. Journal of Medicinal Chemistry. 40: 1608-18. PMID 9171871 DOI: 10.1021/Jm960828P  0.425
1997 Robins MJ, Zou R, Hansske F, Wnuk SF. Synthesis of sugar-modified 2,6-diaminopurine and guanine nucleosides from guanosine via transformations of 2-aminoadenosine and enzymatic deamination with adenosine deaminase Canadian Journal of Chemistry. 75: 762-767. DOI: 10.1139/V97-092  0.421
1997 Robins MJ, Guo Z, Wnuk SF. Elimination of chlorine (radical) or tosylate (anion) from C2' of nucleoside C3' free radicals as model reactions postulated to occur at the active site of ribonucleotide reductases Journal of the American Chemical Society. 119: 3637-3638. DOI: 10.1021/Ja970171C  0.366
1997 Lewandowska E, Neschadimenko V, Wnuk SF, Robins MJ. Efficient removal of sugar O-tosyl groups and heterocycle halogens from purine nucleosides with sodium naphthalenide Tetrahedron. 53: 6295-6302. DOI: 10.1016/S0040-4020(97)00313-X  0.341
1997 Robins MJ, Sarker S, Samano V, Wnuk SF. Nucleic acid related compounds. 94. Remarkably high stereoselective reductions of 2'- and 3'-ketonucleoside derivatives to give arabino, ribo, and xylofuranosyl nucleosides with hydrogen isotopes at C2' and C3' Tetrahedron. 53: 447-456. DOI: 10.1016/S0040-4020(96)01035-6  0.418
1996 Wnuk SF, Liu S, Yuan CS, Borchardt RT, Robins MJ. Inactivation of S-adenosyl-L-homocysteine hydrolase by amide and ester derivatives of adenosine-5'-carboxylic acid. Journal of Medicinal Chemistry. 39: 4162-6. PMID 8863793 DOI: 10.1021/Jm960313Y  0.376
1996 Robins MJ, Zou R, Guo Z, Wnuk SF. Nucleic acid related compounds. 93. A solution for the historic problem of regioselective sugar-base coupling to produce 9-glycosylguanines or 7-glycosylguanines Journal of Organic Chemistry. 61: 9207-9212. DOI: 10.1021/Jo9617023  0.405
1996 Robins MJ, Wnuk SF, Hernández-Thirring AE, Samano MC. Nucleic acid related compounds. 91. Biomimetic reactions are in harmony with loss of 2'-substituents as free radicals (not anions) during mechanism-based inactivation of ribonucleotide reductases. Differential interactions of azide, halogen, and alkylthio groups with tributylstannane and triphenylsilane Journal of the American Chemical Society. 118: 11341-11348. DOI: 10.1021/Ja962117M  0.391
1996 Wnuk SF, Robins MJ. Stannyl Radical-Mediated Cleavage of π-Deficient Heterocyclic Sulfones. Synthesis of α-Fluoro Esters and the First Homonucleoside α-Fluoromethylene Phosphonate1 Journal of the American Chemical Society. 118: 2519-2520. DOI: 10.1021/Ja953513S  0.351
1996 Yuan CS, Liu S, Wnuk SF, Robins MJ, Borchardt RT. Design and synthesis of S-adenosylhomocysteine hydrolase inhibitors as broad-spectrum antiviral agents Advances in Antiviral Drug Design. 2: 41-88. DOI: 10.1016/S1075-8593(96)80103-1  0.367
1995 Yuan C, Liu S, Wnuk S, Robins M, Borchardt R. Rational Approaches to the Design of Mechanism-Based Inhibitors of S-Adenosylhomocysteine Hydrolase Nucleosides, Nucleotides and Nucleic Acids. 14: 439-447. DOI: 10.1080/15257779508012403  0.376
1995 Robins MJ, Wilson JS, Madej D, Low NH, Hansske F, Wnuk SF. Nucleic Acid-Related Compounds. 88. Efficient Conversions of Ribonucleosides into Their 2',3'-Anhydro, 2'(and 3')-Deoxy, 2',3'-Didehydro-2',3'-dideoxy, and 2',3'-Dideoxynucleoside Analogs The Journal of Organic Chemistry. 60: 7902-7908. DOI: 10.1021/Jo00129A034  0.432
1994 Yuan CS, Liu S, Wnuk SF, Robins MJ, Borchardt RT. Mechanism of inactivation of S-adenosylhomocysteine hydrolase by (E)-5',6'-didehydro-6'-deoxy-6'-halohomoadenosines. Biochemistry. 33: 3758-65. PMID 8142376 DOI: 10.1021/Bi00178A036  0.316
1994 Wnuk SF, Yuan CS, Borchardt RT, Balzarini J, De Clercq E, Robins MJ. Nucleic acid related compounds. 84. Synthesis of 6'-(E and Z)-halohomovinyl derivatives of adenosine, inactivation of S-adenosyl-L-homocysteine hydrolase, and correlation of anticancer and antiviral potencies with enzyme inhibition. Journal of Medicinal Chemistry. 37: 3579-87. PMID 7932585 DOI: 10.1021/Jm00047A015  0.408
1994 Yuan CS, Wnuk SF, Liu S, Robins MJ, Borchardt RT. (E)-5',6'-didehydro-6'-deoxy-6'-fluorohomoadenosine: a substrate that measures the hydrolytic activity of S-adenosylhomocysteine hydrolase. Biochemistry. 33: 12305-11. PMID 7918452 DOI: 10.1021/Bi00206A038  0.358
1994 Wnuk SF, Stoeckler JD, Robins MJ. Nucleic Acid Related Compounds. 82. Conversions of Adenosine to Inosine 5′-Thioether Derivatives withAspergillus oryzaeAdenosine Deaminase or Alkyl Nitrites. Substrate and Inhibitory Activities of Inosine 5′-Thioether Derivatives with Purine Nucleoside Phosphorylase Nucleosides and Nucleotides. 13: 389-403. DOI: 10.1080/15257779408013249  0.41
1994 Robins MJ, Wnuk SF. Selected Aspects of the Chemistry and Biochemistry of Sulfur-Containing Nucleosides Phosphorus, Sulfur, and Silicon and the Related Elements. 95: 71-88. DOI: 10.1080/10426509408034202  0.433
1994 Robins MJ, Wnuk SF, Mullah KB, Dalley NK, Yuan C, Lee Y, Borchardt RT. Nucleic Acid Related Compounds. 80. Synthesis of 5'-S-(Alkyl and aryl)-5'-fluoro-5'-thioadenosines with Xenon Difluoride or (Diethylamido)sulfur Trifluoride, Hydrolysis in Aqueous Buffer, and Inhibition of S-Adenosyl-L-homocysteine hydrolase by derived "Adenosine 5'-Aldehyde" Species The Journal of Organic Chemistry. 59: 544-555. DOI: 10.1021/Jo00082A010  0.426
1993 Liu S, Wnuk SF, Yuan C, Robins MJ, Borchardt RT. Adenosine-5'-carboxaldehyde: a potent inhibitor of S-adenosyl-L-homocysteine hydrolase. Journal of Medicinal Chemistry. 36: 883-7. PMID 8464042 DOI: 10.1021/Jm00059A013  0.31
1993 Wnuk SF, Robins MJ. Nucleic acid related compounds. 78. Stereocontrolled syntheses of 6′(E and Z)-halovinyl analogues from uridine-derived vinylsulfones via vinyltin intermediates Canadian Journal of Chemistry. 71: 192-198. DOI: 10.1139/V93-028  0.398
1993 Robins MJ, Wnuk SF. Nucleic acid related compounds. 79. Efficient conversions of thioethers to .alpha.-fluoro thioethers with DAST or DAST/antimony(III) chloride The Journal of Organic Chemistry. 58: 3800-3801. DOI: 10.1021/Jo00067A009  0.356
1993 Wnuk SF, Dalley NK, Robins MJ. Nucleic acid related compounds. 76. Synthesis of 5'(E and Z)-chloro-4',5'-didehydro-5'-deoxyadenosines via chlorination and thermolysis of adenosine 5'-sulfoxides. Mechanism-based inhibition of S-adenosyl-L-homocysteine hydrolase The Journal of Organic Chemistry. 58: 111-117. DOI: 10.1021/Jo00053A022  0.362
1992 Robins MJ, Hawrelak SD, Hernández AE, Wnuk SF. Nucleic Acid Related Compounds. LXXXI. Efficient General Synthesis of Purine (Amino, Azido, and Triflate)-Sugar Nucleosides Nucleosides and Nucleotides. 11: 821-834. DOI: 10.1080/07328319208021743  0.388
1992 Robins MJ, Mullah KB, Wnuk SF, Dalley NK. Nucleic acid related compounds. 73. Fluorination of uridine 2'-thioethers with xenon difluoride or (diethylamino)sulfur trifluoride. Synthesis of stable 2'-[alkyl(or aryl)sulfonyl]-2'-deoxy-2'-fluorouridines The Journal of Organic Chemistry. 57: 2357-2364. DOI: 10.1021/Jo00034A031  0.426
1991 Wnuk SF, Dalley NK, Robins MJ. Nucleic acid related compounds. 67. Synthesis of 5′-amino and 5′-methylthio chain-extended nucleosides from uridine Canadian Journal of Chemistry. 69: 2104-2111. DOI: 10.1139/V91-303  0.388
1991 Robins MJ, Hansske F, Wnuk SF, Kanai T. Nucleic acid related compounds. 66. Improved syntheses of 5′-chloro-5′-deoxy- and 5′-S-aryl(or alkyl)-5′-thionucleosides Canadian Journal of Chemistry. 69: 1468-1474. DOI: 10.1139/V91-217  0.397
1991 Wnuk SF, Robins MJ. Nucleic acid related compounds. 63. Synthesis of 5′-deoxy-5′-methyleneadenosine and related Wittig-extended nucleosides Canadian Journal of Chemistry. 69: 334-338. DOI: 10.1139/V91-051  0.389
1991 Robins MJ, Wnuk SF, Mullah KB, Dalley NK. Nucleic acid-related compounds. 68. Fluorination at C5' of nucleoside 5'-thioethers with DAST/antimony(III) chloride or xenon difluoride to give 5'-S-aryl-5'-fluoro-5'-thiouridines The Journal of Organic Chemistry. 56: 6878-6884. DOI: 10.1021/Jo00024A033  0.361
1990 Wnuk SF, Robins MJ. Antimony(III) chloride exerts potent catalysis of the conversion of sulfoxides to .alpha.-fluoro thioethers with (diethylamino)sulfur trifluoride The Journal of Organic Chemistry. 55: 4757-4760. DOI: 10.1021/Jo00302A052  0.31
1990 Wnuk S, Wyrzykiewicz E, Kaczmarek E, Kinastowski S. Carbon-13 chemical shift assignments of derivatives of benzoic acid Magnetic Resonance in Chemistry. 28: 271-275. DOI: 10.1002/Mrc.1260280315  0.344
1988 Kinastowski S, Wnuk S, Kaczmarek E. The Rearrangement ofortho-Nitrobenzylidenemalonate Derivatives in Reactions with Amines. Applications to Organic Synthesis Synthesis. 1988: 111-118. DOI: 10.1055/S-1988-27483  0.36
1983 Kinastowski S, Wnuk S. A Convenient One-Step Synthesis of Ethyl 2-[N-(Diethoxycarbonyl)(ethoxy)-methyl]amino-4-nitrobenzoate and Analogues by Rearrangement of 2,4-Dinitrobenzylidenemalonates Synthesis. 1983: 654-659. DOI: 10.1055/S-1983-30462  0.363
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