| Year |
Citation |
Score |
| 2023 |
Van Laar AD, Webb KR, Keeney MT, Van Laar VS, Zharikov A, Burton EA, Hastings TG, Glajch KE, Hirst WD, Greenamyre JT, Rocha EM. Transient exposure to rotenone causes degeneration and progressive parkinsonian motor deficits, neuroinflammation, and synucleinopathy. Npj Parkinson's Disease. 9: 121. PMID 37567894 DOI: 10.1038/s41531-023-00561-6 |
0.767 |
|
| 2022 |
Keeney MT, Hoffman EK, Farmer K, Bodle CR, Fazzari M, Zharikov A, Castro SL, Hu X, Mortimer A, Kofler JK, Cifuentes-Pagano E, Pagano PJ, Burton EA, Hastings TG, Greenamyre JT, et al. NADPH oxidase 2 activity in Parkinson's disease. Neurobiology of Disease. 105754. PMID 35577065 DOI: 10.1016/j.nbd.2022.105754 |
0.427 |
|
| 2020 |
Bucher ML, Barrett CW, Moon CJ, Mortimer AD, Burton EA, Greenamyre JT, Hastings TG. Acquired dysregulation of dopamine homeostasis reproduces features of Parkinson's disease. Npj Parkinson's Disease. 6: 34. PMID 33298952 DOI: 10.1038/s41531-020-00134-x |
0.843 |
|
| 2020 |
Van Laar VS, Chen J, Zharikov AD, Bai Q, Di Maio R, Dukes AA, Hastings TG, Watkins SC, Greenamyre JT, St Croix CM, Burton EA. α-Synuclein amplifies cytoplasmic peroxide flux and oxidative stress provoked by mitochondrial inhibitors in CNS dopaminergic neurons in vivo. Redox Biology. 37: 101695. PMID 32905883 DOI: 10.1016/J.Redox.2020.101695 |
0.772 |
|
| 2019 |
Rocha EM, De Miranda BR, Castro S, Drolet R, Hatcher NG, Yao L, Smith SM, Keeney MT, Di Maio R, Kofler J, Hastings TG, Greenamyre JT. LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinson's disease. Neurobiology of Disease. 104626. PMID 31618685 DOI: 10.1016/J.Nbd.2019.104626 |
0.331 |
|
| 2018 |
Van Laar VS, Otero PA, Hastings TG, Berman SB. Potential Role of Mic60/Mitofilin in Parkinson's Disease. Frontiers in Neuroscience. 12: 898. PMID 30740041 DOI: 10.3389/Fnins.2018.00898 |
0.773 |
|
| 2018 |
Di Maio R, Hoffman EK, Rocha EM, Keeney MT, Sanders LH, De Miranda BR, Zharikov A, Van Laar A, Stepan AF, Lanz TA, Kofler JK, Burton EA, Alessi DR, Hastings TG, Greenamyre JT. LRRK2 activation in idiopathic Parkinson's disease. Science Translational Medicine. 10. PMID 30045977 DOI: 10.1126/Scitranslmed.Aar5429 |
0.357 |
|
| 2016 |
Di Maio R, Barrett PJ, Hoffman EK, Barrett CW, Zharikov A, Borah A, Hu X, McCoy J, Chu CT, Burton EA, Hastings TG, Greenamyre JT. α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease. Science Translational Medicine. 8: 342ra78. PMID 27280685 DOI: 10.1126/Scitranslmed.Aaf3634 |
0.434 |
|
| 2016 |
Van Laar VS, Berman SB, Hastings TG. Mic60/mitofilin overexpression alters mitochondrial dynamics and attenuates vulnerability of dopaminergic cells to dopamine and rotenone. Neurobiology of Disease. 91: 247-61. PMID 27001148 DOI: 10.1016/j.nbd.2016.03.015 |
0.831 |
|
| 2015 |
Zharikov AD, Cannon JR, Tapias V, Bai Q, Horowitz MP, Shah V, El Ayadi A, Hastings TG, Greenamyre JT, Burton EA. shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson's disease model. The Journal of Clinical Investigation. PMID 26075822 DOI: 10.1172/Jci64502 |
0.404 |
|
| 2013 |
Hauser DN, Dukes AA, Mortimer AD, Hastings TG. Dopamine quinone modifies and decreases the abundance of the mitochondrial selenoprotein glutathione peroxidase 4. Free Radical Biology & Medicine. 65: 419-27. PMID 23816523 DOI: 10.1016/J.Freeradbiomed.2013.06.030 |
0.834 |
|
| 2013 |
Hauser DN, Hastings TG. Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism Neurobiology of Disease. 51: 35-42. PMID 23064436 DOI: 10.1016/J.Nbd.2012.10.011 |
0.779 |
|
| 2013 |
Hauser DN, Dukes AA, Mortimer AD, Hastings TG. Dopamine quinone modifies and decreases the abundance of the mitochondrial selenoprotein glutathione peroxidase 4 Free Radical Biology and Medicine. 65: 419-427. DOI: 10.1016/j.freeradbiomed.2013.06.030 |
0.817 |
|
| 2013 |
Hastings TG, Mortimer A, Hauser D. Dopamine Oxidation and Quinone Modification of Proteins: Mechanisms of Toxicity and Implications for Parkinson's Disease Catecholamine Research in the 21st Century: Abstracts and Graphical Abstracts, 10th International Catecholamine Symposium, 2012. 122. DOI: 10.1016/B978-0-12-800044-1.00105-7 |
0.799 |
|
| 2011 |
Hu X, Weng Z, Chu CT, Zhang L, Cao G, Gao Y, Signore A, Zhu J, Hastings T, Greenamyre JT, Chen J. Peroxiredoxin-2 protects against 6-hydroxydopamine-induced dopaminergic neurodegeneration via attenuation of the apoptosis signal-regulating kinase (ASK1) signaling cascade. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 247-61. PMID 21209210 DOI: 10.1523/JNEUROSCI.4589-10.2011 |
0.383 |
|
| 2009 |
Hastings TG. The role of dopamine oxidation in mitochondrial dysfunction: implications for Parkinson's disease. Journal of Bioenergetics and Biomembranes. 41: 469-72. PMID 19967436 DOI: 10.1007/s10863-009-9257-z |
0.589 |
|
| 2009 |
Van Laar VS, Mishizen AJ, Cascio M, Hastings TG. Proteomic identification of dopamine-conjugated proteins from isolated rat brain mitochondria and SH-SY5Y cells. Neurobiology of Disease. 34: 487-500. PMID 19332121 DOI: 10.1016/J.Nbd.2009.03.004 |
0.85 |
|
| 2008 |
Dukes AA, Van Laar VS, Cascio M, Hastings TG. Changes in endoplasmic reticulum stress proteins and aldolase A in cells exposed to dopamine. Journal of Neurochemistry. 106: 333-46. PMID 18384645 DOI: 10.1111/J.1471-4159.2008.05392.X |
0.788 |
|
| 2008 |
Van Laar VS, Dukes AA, Cascio M, Hastings TG. Proteomic analysis of rat brain mitochondria following exposure to dopamine quinone: implications for Parkinson disease. Neurobiology of Disease. 29: 477-89. PMID 18226537 DOI: 10.1016/J.Nbd.2007.11.007 |
0.822 |
|
| 2008 |
Chen L, Ding Y, Cagniard B, Van Laar AD, Mortimer A, Chi W, Hastings TG, Kang UJ, Zhuang X. Unregulated cytosolic dopamine causes neurodegeneration associated with oxidative stress in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 425-33. PMID 18184785 DOI: 10.1523/Jneurosci.3602-07.2008 |
0.584 |
|
| 2007 |
Weng Z, Signore AP, Gao Y, Wang S, Zhang F, Hastings T, Yin XM, Chen J. Leptin protects against 6-hydroxydopamine-induced dopaminergic cell death via mitogen-activated protein kinase signaling. The Journal of Biological Chemistry. 282: 34479-91. PMID 17895242 DOI: 10.1074/Jbc.M705426200 |
0.471 |
|
| 2006 |
Tehranian R, Montoya SE, Van Laar AD, Hastings TG, Perez RG. Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells. Journal of Neurochemistry. 99: 1188-96. PMID 16981894 DOI: 10.1111/j.1471-4159.2006.04146.x |
0.433 |
|
| 2006 |
Signore AP, Weng Z, Hastings T, Van Laar AD, Liang Q, Lee YJ, Chen J. Erythropoietin protects against 6-hydroxydopamine-induced dopaminergic cell death. Journal of Neurochemistry. 96: 428-43. PMID 16336625 DOI: 10.1111/J.1471-4159.2005.03587.X |
0.503 |
|
| 2005 |
Liang Q, Smith AD, Pan S, Tyurin VA, Kagan VE, Hastings TG, Schor NF. Neuroprotective effects of TEMPOL in central and peripheral nervous system models of Parkinson's disease Biochemical Pharmacology. 70: 1371-1381. PMID 16144694 DOI: 10.1016/J.Bcp.2005.04.011 |
0.422 |
|
| 2005 |
Dukes AA, Korwek KM, Hastings TG. The effect of endogenous dopamine in rotenone-induced toxicity in PC12 cells. Antioxidants & Redox Signaling. 7: 630-8. PMID 15890007 DOI: 10.1089/Ars.2005.7.630 |
0.818 |
|
| 2004 |
Perez RG, Hastings TG. Could a loss of alpha-synuclein function put dopaminergic neurons at risk? Journal of Neurochemistry. 89: 1318-24. PMID 15189334 DOI: 10.1111/j.1471-4159.2004.02423.x |
0.493 |
|
| 2004 |
Greenamyre JT, Hastings TG. Biomedicine. Parkinson's--divergent causes, convergent mechanisms. Science (New York, N.Y.). 304: 1120-2. PMID 15155938 DOI: 10.1126/science.1098966 |
0.342 |
|
| 2004 |
LaVoie MJ, Card JP, Hastings TG. Microglial activation precedes dopamine terminal pathology in methamphetamine-induced neurotoxicity. Experimental Neurology. 187: 47-57. PMID 15081587 DOI: 10.1016/J.Expneurol.2004.01.010 |
0.375 |
|
| 2002 |
Larsen KE, Fon EA, Hastings TG, Edwards RH, Sulzer D. Methamphetamine-induced degeneration of dopaminergic neurons involves autophagy and upregulation of dopamine synthesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 8951-60. PMID 12388602 DOI: 10.1523/Jneurosci.22-20-08951.2002 |
0.477 |
|
| 2002 |
Zigmond MJ, Hastings TG, Perez RG. Increased dopamine turnover after partial loss of dopaminergic neurons: compensation or toxicity? Parkinsonism & Related Disorders. 8: 389-93. PMID 12217625 DOI: 10.1016/S1353-8020(02)00019-6 |
0.495 |
|
| 2002 |
Chen D, Cao G, Hastings T, Feng Y, Pei W, O'Horo C, Chen J. Age-dependent decline of DNA repair activity for oxidative lesions in rat brain mitochondria. Journal of Neurochemistry. 81: 1273-84. PMID 12068075 DOI: 10.1046/J.1471-4159.2002.00916.X |
0.362 |
|
| 2000 |
Rabinovic AD, Lewis DA, Hastings TG. Role of oxidative changes in the degeneration of dopamine terminals after injection of neurotoxic levels of dopamine. Neuroscience. 101: 67-76. PMID 11068137 DOI: 10.1016/S0306-4522(00)00293-1 |
0.812 |
|
| 1999 |
LaVoie MJ, Hastings TG. Peroxynitrite- and nitrite-induced oxidation of dopamine: implications for nitric oxide in dopaminergic cell loss. Journal of Neurochemistry. 73: 2546-54. PMID 10582617 DOI: 10.1046/J.1471-4159.1999.0732546.X |
0.487 |
|
| 1999 |
Berman SB, Hastings TG. Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria: Implications for Parkinson's disease Journal of Neurochemistry. 73: 1127-1137. PMID 10461904 DOI: 10.1046/j.1471-4159.1999.0731127.x |
0.668 |
|
| 1999 |
Stokes AH, Hastings TG, Vrana KE. Cytotoxic and genotoxic potential of dopamine. Journal of Neuroscience Research. 55: 659-65. PMID 10220107 DOI: 10.1002/(Sici)1097-4547(19990315)55:6<659::Aid-Jnr1>3.0.Co;2-C |
0.547 |
|
| 1999 |
LaVoie MJ, Hastings TG. Dopamine quinone formation and protein modification associated with the striatal neurotoxicity of methamphetamine: evidence against a role for extracellular dopamine. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 1484-91. PMID 9952424 DOI: 10.1523/Jneurosci.19-04-01484.1999 |
0.584 |
|
| 1998 |
Rabinovic AD, Hastings TG. Role of endogenous glutathione in the oxidation of dopamine. Journal of Neurochemistry. 71: 2071-8. PMID 9798932 DOI: 10.1046/J.1471-4159.1998.71052071.X |
0.813 |
|
| 1997 |
Berman SB, Hastings TG. Inhibition of glutamate transport in synaptosomes by dopamine oxidation and reactive oxygen species Journal of Neurochemistry. 69: 1185-1195. PMID 9282942 |
0.475 |
|
| 1997 |
Hastings TG, Zigmond MJ. Loss of dopaminergic neurons in parkinsonism: possible role of reactive dopamine metabolites. Journal of Neural Transmission. Supplementum. 49: 103-10. PMID 9266419 |
0.457 |
|
| 1997 |
Hoyt KR, Reynolds IJ, Hastings TG. Mechanisms of dopamine-induced cell death in cultured rat forebrain neurons: interactions with and differences from glutamate-induced cell death. Experimental Neurology. 143: 269-81. PMID 9056389 DOI: 10.1006/Exnr.1996.6374 |
0.498 |
|
| 1997 |
Hoyt KR, Gallagher AJ, Hastings TG, Reynolds IJ. Characterization of hydrogen peroxide toxicity in cultured rat forebrain neurons. Neurochemical Research. 22: 333-40. PMID 9051670 DOI: 10.1023/A:1022403224901 |
0.317 |
|
| 1996 |
Hastings TG, Lewis DA, Zigmond MJ. Reactive dopamine metabolites and neurotoxicity: implications for Parkinson's disease. Advances in Experimental Medicine and Biology. 387: 97-106. PMID 8794199 DOI: 10.1007/978-1-4757-9480-9_13 |
0.333 |
|
| 1996 |
Berman SB, Zigmond MJ, Hastings TG. Modification of dopamine transporter function: effect of reactive oxygen species and dopamine. Journal of Neurochemistry. 67: 593-600. PMID 8764584 |
0.509 |
|
| 1996 |
Hastings TG, Lewis DA, Zigmond MJ. Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections. Proceedings of the National Academy of Sciences of the United States of America. 93: 1956-61. PMID 8700866 DOI: 10.1073/Pnas.93.5.1956 |
0.574 |
|
| 1995 |
Hastings TG. Enzymatic oxidation of dopamine: The role of prostaglandin H synthase Journal of Neurochemistry. 64: 919-924. PMID 7830086 |
0.519 |
|
| 1995 |
Reynolds IJ, Hastings TG. Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 3318-27. PMID 7751912 DOI: 10.1523/Jneurosci.15-05-03318.1995 |
0.316 |
|
| 1994 |
Hastings TG, Zigmond MJ. Identification of catechol-protein conjugates in neostriatal slices incubated with [3H]dopamine: impact of ascorbic acid and glutathione. Journal of Neurochemistry. 63: 1126-32. PMID 8051554 DOI: 10.1046/j.1471-4159.1994.63031126.x |
0.528 |
|
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