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Joaquin Espinosa - Publications

Affiliations: 
Molecular, Cellular and Developmental Biology University of Colorado, Boulder, Boulder, CO, United States 
Area:
Human Development, Molecular Biology, Neuroscience Biology
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57 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Cozzolino K, Sanford L, Hunter S, Molison K, Erickson B, Jones T, Ajit D, Galbraith MD, Espinosa JM, Bentley DL, Allen MA, Dowell RD, Taatjes DJ. Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome. Biorxiv : the Preprint Server For Biology. PMID 37461585 DOI: 10.1101/2023.07.05.547813  0.338
2023 Ludwig MP, Galbraith MD, Eduthan NP, Hill AA, Clay MR, Moreno Tellez C, Wilky BA, Elias A, Espinosa JM, Sullivan KD. Proteasome Inhibition Sensitizes Liposarcoma to MDM2 Inhibition with Nutlin-3 by Activating the ATF4/CHOP Stress Response Pathway. Cancer Research. PMID 37205634 DOI: 10.1158/0008-5472.CAN-22-3173  0.316
2023 Szwarc MM, Guarnieri AL, Joshi M, Duc HN, Laird MC, Pandey A, Khanal S, Dohm E, Bui AK, Sullivan KD, Galbraith MD, Andrysik Z, Espinosa JM. FAM193A is a positive regulator of p53 activity. Cell Reports. 42: 112230. PMID 36897777 DOI: 10.1016/j.celrep.2023.112230  0.509
2023 Tatavosian R, Donovan MG, Galbraith MD, Duc HN, Szwarc MM, Joshi MU, Frieman A, Bilousova G, Cao Y, Smith KP, Song K, Rachubinski AL, Andrysik Z, Espinosa JM. Cell differentiation modifies the p53 transcriptional program through a combination of gene silencing and constitutive transactivation. Cell Death and Differentiation. PMID 36681780 DOI: 10.1038/s41418-023-01113-4  0.579
2022 Donovan MG, Galbraith MD, Espinosa JM. Multi-omics investigation reveals functional specialization of transcriptional cyclin dependent kinases in cancer biology. Scientific Reports. 12: 22505. PMID 36577800 DOI: 10.1038/s41598-022-26860-1  0.395
2022 Andrysik Z, Sullivan KD, Kieft JS, Espinosa JM. PPM1D suppresses p53-dependent transactivation and cell death by inhibiting the Integrated Stress Response. Nature Communications. 13: 7400. PMID 36456590 DOI: 10.1038/s41467-022-35089-5  0.484
2021 Galbraith MD, Andrysik Z, Sullivan KD, Espinosa JM. Global Analyses to Identify Direct Transcriptional Targets of p53. Methods in Molecular Biology (Clifton, N.J.). 2267: 19-56. PMID 33786783 DOI: 10.1007/978-1-0716-1217-0_3  0.598
2021 Andrysik Z, Bender H, Galbraith MD, Espinosa JM. Multi-omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic response. Nature Communications. 12: 1375. PMID 33654095 DOI: 10.1038/s41467-021-21687-2  0.364
2020 Rizzotto D, Zaccara S, Rossi A, Galbraith MD, Andrysik Z, Pandey A, Sullivan KD, Quattrone A, Espinosa JM, Dassi E, Inga A. Nutlin-Induced Apoptosis Is Specified by a Translation Program Regulated by PCBP2 and DHX30. Cell Reports. 30: 4355-4369.e6. PMID 32234473 DOI: 10.1016/J.Celrep.2020.03.011  0.417
2019 Steinparzer I, Sedlyarov V, Rubin JD, Eislmayr K, Galbraith MD, Levandowski CB, Vcelkova T, Sneezum L, Wascher F, Amman F, Kleinova R, Bender H, Andrysik Z, Espinosa JM, Superti-Furga G, et al. Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions. Molecular Cell. PMID 31495563 DOI: 10.1016/J.Molcel.2019.07.034  0.454
2019 Espinosa JM. Transcriptional CDKs in the spotlight. Transcription. 10: 45-46. PMID 30946639 DOI: 10.1080/21541264.2019.1597479  0.509
2018 Sullivan KD, Galbraith MD, Andrysik Z, Espinosa JM. Mechanisms of transcriptional regulation by p53. Cell Death and Differentiation. 25: 133-143. PMID 31745311 DOI: 10.1038/cdd.2017.174  0.599
2018 Galbraith MD, Bender H, Espinosa JM. Therapeutic targeting of transcriptional cyclin-dependent kinases. Transcription. 1-19. PMID 30409083 DOI: 10.1080/21541264.2018.1539615  0.426
2018 Fitzwalter BE, Towers CG, Sullivan KD, Andrysik Z, Hoh M, Ludwig M, O'Prey J, Ryan KM, Espinosa JM, Morgan MJ, Thorburn A. Autophagy Inhibition Mediates Apoptosis Sensitization in Cancer Therapy by Relieving FOXO3a Turnover. Developmental Cell. 44: 555-565.e3. PMID 29533771 DOI: 10.1016/J.Devcel.2018.02.014  0.301
2017 Sullivan KD, Galbraith MD, Andrysik Z, Espinosa JM. Mechanisms of transcriptional regulation by p53. Cell Death and Differentiation. PMID 29125602 DOI: 10.1038/Cdd.2017.174  0.604
2017 Andrysik Z, Galbraith MD, Guarnieri AL, Zaccara S, Sullivan KD, Pandey A, MacBeth M, Inga A, Espinosa JM. Identification of a core TP53 transcriptional program with highly distributed tumor suppressive activity. Genome Research. PMID 28904012 DOI: 10.1101/Gr.220533.117  0.415
2017 Audetat KA, Galbraith MD, Odell AT, Lee T, Pandey A, Espinosa JM, Dowell RD, Taatjes DJ. A kinase-independent role for CDK19 in p53 response. Molecular and Cellular Biology. PMID 28416637 DOI: 10.1128/Mcb.00626-16  0.609
2016 Sullivan KD, Lewis HC, Hill AA, Pandey A, Jackson LP, Cabral JM, Smith KP, Liggett LA, Gomez EB, Galbraith MD, DeGregori J, Espinosa JM. Trisomy 21 consistently activates the interferon response. Elife. 5. PMID 27472900 DOI: 10.7554/Elife.16220  0.357
2016 Perez-Perri JI, Dengler VL, Audetat KA, Pandey A, Bonner EA, Urh M, Mendez J, Daniels DL, Wappner P, Galbraith MD, Espinosa JM. The TIP60 Complex Is a Conserved Coactivator of HIF1A. Cell Reports. PMID 27320910 DOI: 10.1016/j.celrep.2016.05.082  0.516
2015 Towers CG, Guarnieri AL, Micalizzi DS, Harrell JC, Gillen AE, Kim J, Wang CA, Oliphant MU, Drasin DJ, Guney MA, Kabos P, Sartorius CA, Tan AC, Perou CM, Espinosa JM, et al. The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p. Nature Communications. 6: 10077. PMID 26687066 DOI: 10.1038/Ncomms10077  0.39
2015 Abraham CG, Espinosa JM. The Crusade against Mutant p53: Does the COMPASS Point to the Holy Grail? Cancer Cell. 28: 407-8. PMID 26461087 DOI: 10.1016/j.ccell.2015.09.019  0.424
2015 Espinosa JM, Sullivan KD. A signature for success. Elife. 4. PMID 26079875 DOI: 10.7554/Elife.08773  0.344
2015 Tentler JJ, Ionkina AA, Tan AC, Newton TP, Pitts TM, Glogowska MJ, Kabos P, Sartorius CA, Sullivan KD, Espinosa JM, Eckhardt SG, Diamond JR. p53 Family Members Regulate Phenotypic Response to Aurora Kinase A Inhibition in Triple-Negative Breast Cancer. Molecular Cancer Therapeutics. 14: 1117-29. PMID 25758253 DOI: 10.1158/1535-7163.Mct-14-0538-T  0.433
2015 Sullivan KD, Palaniappan VV, Espinosa JM. ATM regulates cell fate choice upon p53 activation by modulating mitochondrial turnover and ROS levels. Cell Cycle (Georgetown, Tex.). 14: 56-63. PMID 25483068 DOI: 10.4161/15384101.2014.973330  0.494
2014 Allen MA, Andrysik Z, Dengler VL, Mellert HS, Guarnieri A, Freeman JA, Sullivan KD, Galbraith MD, Luo X, Kraus WL, Dowell RD, Espinosa JM. Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms. Elife. 3: e02200. PMID 24867637 DOI: 10.7554/Elife.02200  0.641
2014 Guarnieri AL, Espinosa JM. Back to bases: how a nucleotide biosynthetic enzyme controls p53 activation. Molecular Cell. 53: 365-7. PMID 24507714 DOI: 10.1016/j.molcel.2014.01.025  0.307
2014 Dengler VL, Galbraith MD, Espinosa JM. Transcriptional regulation by hypoxia inducible factors. Critical Reviews in Biochemistry and Molecular Biology. 49: 1-15. PMID 24099156 DOI: 10.3109/10409238.2013.838205  0.423
2013 Galbraith MD, Saxton J, Li L, Shelton SJ, Zhang H, Espinosa JM, Shaw PE. ERK phosphorylation of MED14 in promoter complexes during mitogen-induced gene activation by Elk-1. Nucleic Acids Research. 41: 10241-53. PMID 24049075 DOI: 10.1093/nar/gkt837  0.493
2013 Galbraith MD, Allen MA, Bensard CL, Wang X, Schwinn MK, Qin B, Long HW, Daniels DL, Hahn WC, Dowell RD, Espinosa JM. HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia. Cell. 153: 1327-39. PMID 23746844 DOI: 10.1016/J.Cell.2013.04.048  0.525
2013 Andrysik Z, Kim J, Tan AC, Espinosa JM. A genetic screen identifies TCF3/E2A and TRIAP1 as pathway-specific regulators of the cellular response to p53 activation. Cell Reports. 3: 1346-54. PMID 23684607 DOI: 10.1016/j.celrep.2013.04.014  0.561
2013 Gallant-Behm CL, Espinosa JM. ΔNp63α utilizes multiple mechanisms to repress transcription in squamous cell carcinoma cells. Cell Cycle (Georgetown, Tex.). 12: 409-16. PMID 23324337 DOI: 10.4161/cc.23593  0.528
2013 Freeman JA, Espinosa JM. The impact of post-transcriptional regulation in the p53 network. Briefings in Functional Genomics. 12: 46-57. PMID 23242178 DOI: 10.1093/bfgp/els058  0.569
2012 Gallant-Behm CL, Ramsey MR, Bensard CL, Nojek I, Tran J, Liu M, Ellisen LW, Espinosa JM. ΔNp63α represses anti-proliferative genes via H2A.Z deposition. Genes & Development. 26: 2325-36. PMID 23019126 DOI: 10.1101/gad.198069.112  0.552
2012 Smallwood A, Hon GC, Jin F, Henry RE, Espinosa JM, Ren B. CBX3 regulates efficient RNA processing genome-wide. Genome Research. 22: 1426-36. PMID 22684280 DOI: 10.1101/Gr.124818.111  0.436
2012 Sullivan KD, Padilla-Just N, Henry RE, Porter CC, Kim J, Tentler JJ, Eckhardt SG, Tan AC, DeGregori J, Espinosa JM. ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53. Nature Chemical Biology. 8: 646-54. PMID 22660439 DOI: 10.1038/Nchembio.965  0.524
2012 Sullivan KD, Gallant-Behm CL, Henry RE, Fraikin JL, Espinosa JM. The p53 circuit board. Biochimica Et Biophysica Acta. 1825: 229-44. PMID 22333261 DOI: 10.1016/J.Bbcan.2012.01.004  0.524
2012 Henry RE, Andrysik Z, París R, Galbraith MD, Espinosa JM. A DR4:tBID axis drives the p53 apoptotic response by promoting oligomerization of poised BAX. The Embo Journal. 31: 1266-78. PMID 22246181 DOI: 10.1038/emboj.2011.498  0.451
2012 Espinosa JM. Get back TFIIF, don't let me Gdown1. Molecular Cell. 45: 3-5. PMID 22244325 DOI: 10.1016/j.molcel.2011.12.016  0.31
2011 Galbraith MD, Espinosa JM. Lessons on transcriptional control from the serum response network. Current Opinion in Genetics & Development. 21: 160-6. PMID 21316215 DOI: 10.1016/j.gde.2011.01.011  0.407
2010 Galbraith MD, Donner AJ, Espinosa JM. CDK8: a positive regulator of transcription. Transcription. 1: 4-12. PMID 21327159 DOI: 10.4161/trns.1.1.12373  0.782
2010 Espinosa JM. The meaning of pausing. Molecular Cell. 40: 507-8. PMID 21095581 DOI: 10.1016/j.molcel.2010.11.025  0.356
2010 Gomes NP, Espinosa JM. Disparate chromatin landscapes and kinetics of inactivation impact differential regulation of p53 target genes. Cell Cycle (Georgetown, Tex.). 9: 3428-37. PMID 20818159 DOI: 10.4161/Cc.9.17.12998  0.811
2010 Gomes NP, Espinosa JM. Gene-specific repression of the p53 target gene PUMA via intragenic CTCF-Cohesin binding. Genes & Development. 24: 1022-34. PMID 20478995 DOI: 10.1101/Gad.1881010  0.815
2010 Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, ... ... Espinosa JM, et al. The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell. 140: 280-93. PMID 20141841 DOI: 10.1016/J.Cell.2009.12.041  0.317
2010 Donner AJ, Ebmeier CC, Taatjes DJ, Espinosa JM. CDK8 is a positive regulator of transcriptional elongation within the serum response network. Nature Structural & Molecular Biology. 17: 194-201. PMID 20098423 DOI: 10.1038/Nsmb.1752  0.777
2010 Gomes NP, Espinosa JM. Differential regulation of p53 target genes: it's (core promoter) elementary. Genes & Development. 24: 111-4. PMID 20080948 DOI: 10.1101/Gad.1893610  0.813
2009 Beckerman R, Donner AJ, Mattia M, Peart MJ, Manley JL, Espinosa JM, Prives C. A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint. Genes & Development. 23: 1364-77. PMID 19487575 DOI: 10.1101/Gad.1795709  0.79
2009 Knuesel MT, Meyer KD, Donner AJ, Espinosa JM, Taatjes DJ. The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator. Molecular and Cellular Biology. 29: 650-61. PMID 19047373 DOI: 10.1128/Mcb.00993-08  0.732
2008 París R, Henry RE, Stephens SJ, McBryde M, Espinosa JM. Multiple p53-independent gene silencing mechanisms define the cellular response to p53 activation. Cell Cycle (Georgetown, Tex.). 7: 2427-33. PMID 18677110 DOI: 10.4161/cc.6420  0.516
2008 Wade M, Rodewald LW, Espinosa JM, Wahl GM. BH3 activation blocks Hdmx suppression of apoptosis and cooperates with Nutlin to induce cell death. Cell Cycle (Georgetown, Tex.). 7: 1973-82. PMID 18604177 DOI: 10.4161/Cc.7.13.6072  0.358
2008 Meyer KD, Donner AJ, Knuesel MT, York AG, Espinosa JM, Taatjes DJ. Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3. The Embo Journal. 27: 1447-57. PMID 18418385 DOI: 10.1038/Emboj.2008.78  0.741
2008 Glover-Cutter K, Kim S, Espinosa J, Bentley DL. RNA polymerase II pauses and associates with pre-mRNA processing factors at both ends of genes. Nature Structural & Molecular Biology. 15: 71-8. PMID 18157150 DOI: 10.1038/Nsmb1352  0.484
2007 Donner AJ, Hoover JM, Szostek SA, Espinosa JM. Stimulus-specific transcriptional regulation within the p53 network. Cell Cycle (Georgetown, Tex.). 6: 2594-8. PMID 17957141 DOI: 10.4161/Cc.6.21.4893  0.815
2007 Donner AJ, Szostek S, Hoover JM, Espinosa JM. CDK8 is a stimulus-specific positive coregulator of p53 target genes. Molecular Cell. 27: 121-33. PMID 17612495 DOI: 10.1016/J.Molcel.2007.05.026  0.821
2006 Gomes NP, Bjerke G, Llorente B, Szostek SA, Emerson BM, Espinosa JM. Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program. Genes & Development. 20: 601-12. PMID 16510875 DOI: 10.1101/Gad.1398206  0.809
2005 Gómez EB, Espinosa JM, Forsburg SL. Schizosaccharomyces pombe mst2+ encodes a MYST family histone acetyltransferase that negatively regulates telomere silencing. Molecular and Cellular Biology. 25: 8887-903. PMID 16199868 DOI: 10.1128/MCB.25.20.8887-8903.2005  0.305
2003 Espinosa JM, Verdun RE, Emerson BM. p53 functions through stress- and promoter-specific recruitment of transcription initiation components before and after DNA damage. Molecular Cell. 12: 1015-27. PMID 14580351 DOI: 10.1016/S1097-2765(03)00359-9  0.582
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