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Ismail Syed, Ph.D. - Publications

Affiliations: 
Medicine Harvard Medical School, Boston, MA, United States 
 2011 Pharmaceutical Sciences Wayne State University, Detroit, MI, United States 
Area:
Pharmacy, Pharmacology
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29 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Rubin de Celis MF, Garcia-Martin R, Syed I, Lee J, Aguayo-Mazzucato C, Bonner-Weir S, Kahn BB. PAHSAs reduce cellular senescence and protect pancreatic beta cells from metabolic stress through regulation of Mdm2/p53. Proceedings of the National Academy of Sciences of the United States of America. 119: e2206923119. PMID 36375063 DOI: 10.1073/pnas.2206923119  0.578
2021 Aryal P, Syed I, Lee J, Patel R, Nelson AT, Siegel D, Saghatelian A, Kahn BB. Distinct Biological Activities of Isomers from Different Families of Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs). Journal of Lipid Research. 100108. PMID 34418413 DOI: 10.1016/j.jlr.2021.100108  0.651
2019 Syed I, Rubinde Celis MF, Mohan JF, Moraes-Vieira PM, Vijayakumar A, Nelson AT, Siegel D, Saghatelian A, Mathis D, Kahn BB. PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice. The Journal of Clinical Investigation. 129. PMID 31380811 DOI: 10.1172/Jci122445  0.646
2019 SYED I, DE CELIS MFR, MOHAN JF, MORAES-VIERIA PM, VIJAYAKUMAR A, NELSON AT, SIEGEL D, SAGHATELIAN A, MATHIS D, KAHN B. 361-OR: ER Stress Attenuation Is Involved in PAHSA-Induced Reduction of T1D in Nonobese Diabetic (NOD) Mice Diabetes. 68: 361-OR. DOI: 10.2337/Db19-361-Or  0.591
2018 Hammarstedt A, Syed I, Vijayakumar A, Eliasson B, Gogg S, Kahn BB, Smith U. Adipose tissue dysfunction is associated with low levels of the novel Palmitic Acid Hydroxystearic Acids. Scientific Reports. 8: 15757. PMID 30361530 DOI: 10.1038/S41598-018-34113-3  0.592
2018 Syed I, Lee J, Peroni OD, Yore MM, Moraes-Vieira PM, Santoro A, Wellenstein K, Smith U, McGraw TE, Saghatelian A, Kahn BB. Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects. Cell Metabolism. PMID 30244974 DOI: 10.1016/J.Cmet.2018.09.007  0.547
2018 Syed I, Lee J, Moraes-Vieira PM, Donaldson CJ, Sontheimer A, Aryal P, Wellenstein K, Kolar MJ, Nelson AT, Siegel D, Mokrosinski J, Farooqi IS, Zhao JJ, Yore MM, Peroni OD, et al. Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis. Cell Metabolism. 27: 419-427.e4. PMID 29414687 DOI: 10.1016/J.Cmet.2018.01.001  0.673
2018 SANTORO A, ZHOU P, PERONI OD, SYED I, NELSON AT, SIEGEL D, SAGHATELIAN A, KAHN B. Palmitic Acid Esters of Hydroxy Stearic Acids Are Hepatic Insulin Sensitizers in Chow and High-Fat Diet (HFD)–Fed Mice Diabetes. 67: 1838-P. DOI: 10.2337/Db18-1838-P  0.644
2017 Vijayakumar A, Aryal P, Wen J, Syed I, Vazirani RP, Moraes-Vieira PM, Camporez JP, Gallop MR, Perry RJ, Peroni OD, Shulman GI, Saghatelian A, McGraw TE, Kahn BB. Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport. Cell Reports. 21: 1021-1035. PMID 29069585 DOI: 10.1016/J.Celrep.2017.09.091  0.654
2017 Nelson AT, Kolar MJ, Chu Q, Syed I, Kahn BB, Saghatelian A, Siegel D. Stereochemistry of Endogenous Palmitic Acid Ester of 9-Hydroxystearic Acid and Relevance of Absolute Configuration to Regulation. Journal of the American Chemical Society. PMID 28350171 DOI: 10.1021/Jacs.7B01269  0.54
2017 Grünberg JR, Hoffmann JM, Hedjazifar S, Nerstedt A, Jenndahl L, Elvin J, Castellot J, Wei L, Movérare-Skrtic S, Ohlsson C, Holm LM, Bäckhed F, Syed I, Bosch F, Saghatelian A, et al. Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance. Scientific Reports. 7: 43515. PMID 28240264 DOI: 10.1038/Srep43515  0.637
2016 Kolar MJ, Kamat SS, Parsons WH, Homan EA, Maher T, Peroni OD, Syed I, Fjeld K, Molven A, Kahn BB, Cravatt BF, Saghatelian A. Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase. Biochemistry. PMID 27509211 DOI: 10.1021/Acs.Biochem.6B00565  0.568
2016 Zhang T, Chen S, Syed I, Ståhlman M, Kolar MJ, Homan EA, Chu Q, Smith U, Borén J, Kahn BB, Saghatelian A. A LC-MS-based workflow for measurement of branched fatty acid esters of hydroxy fatty acids. Nature Protocols. 11: 747-763. PMID 26985573 DOI: 10.1038/Nprot.2016.040  0.507
2015 Parmar MS, Syed I, Gray JP, Ray SD. Curcumin, Hesperidin, and Rutin Selectively Interfere with Apoptosis Signaling and Attenuate Streptozotocin-Induced Oxidative Stress-Mediated Hyperglycemia. Current Neurovascular Research. PMID 26265154 DOI: 10.2174/1567202612666150812150249  0.497
2014 Prothiwa M, Syed I, Huising MO, van der Meulen T, Donaldson CJ, Trauger SA, Kahn BB, Saghatelian A. Data-driven synthesis of proteolysis-resistant peptide hormones. Journal of the American Chemical Society. 136: 17710-3. PMID 25496053 DOI: 10.1021/Ja5065735  0.578
2014 Yore MM, Syed I, Moraes-Vieira PM, Zhang T, Herman MA, Homan EA, Patel RT, Lee J, Chen S, Peroni OD, Dhaneshwar AS, Hammarstedt A, Smith U, McGraw TE, Saghatelian A, et al. Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. Cell. 159: 318-32. PMID 25303528 DOI: 10.1016/J.Cell.2014.09.035  0.673
2014 Moraes-Vieira PM, Yore MM, Dwyer PM, Syed I, Aryal P, Kahn BB. RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance. Cell Metabolism. 19: 512-26. PMID 24606904 DOI: 10.1016/J.Cmet.2014.01.018  0.656
2014 Kowluru RA, Kowluru A, Veluthakal R, Mohammad G, Syed I, Santos JM, Mishra M. TIAM1-RAC1 signalling axis-mediated activation of NADPH oxidase-2 initiates mitochondrial damage in the development of diabetic retinopathy. Diabetologia. 57: 1047-56. PMID 24554007 DOI: 10.1007/S00125-014-3194-Z  0.622
2012 Arora DK, Syed I, Machhadieh B, McKenna CE, Kowluru A. Rab-geranylgeranyl transferase regulates glucose-stimulated insulin secretion from pancreatic β cells. Islets. 4: 354-8. PMID 23114750 DOI: 10.4161/Isl.22538  0.674
2012 Syed I, Szulc ZM, Ogretmen B, Kowluru A. L- threo -C6-pyridinium-ceramide bromide, a novel cationic ceramide, induces NADPH oxidase activation, mitochondrial dysfunction and loss in cell viability in INS 832/13 β-cells. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 30: 1051-8. PMID 23052231 DOI: 10.1159/000341481  0.681
2012 Syed I, Rathod J, Parmar M, Corcoran GB, Ray SD. Matrix metalloproteinase-9, -10, and -12, MDM2 and p53 expression in mouse liver during dimethylnitrosamine-induced oxidative stress and genomic injury. Molecular and Cellular Biochemistry. 365: 351-61. PMID 22441882 DOI: 10.1007/S11010-012-1277-Z  0.314
2011 Syed I, Kyathanahalli CN, Jayaram B, Govind S, Rhodes CJ, Kowluru RA, Kowluru A. Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet. Diabetes. 60: 2843-52. PMID 21911753 DOI: 10.2337/Db11-0809  0.735
2011 Jayaram B, Syed I, Singh A, Subasinghe W, Kyathanahalli CN, Kowluru A. Isoprenylcysteine carboxyl methyltransferase facilitates glucose-induced Rac1 activation, ROS generation and insulin secretion in INS 832/13 β-cells. Islets. 3: 48-57. PMID 21346419 DOI: 10.4161/Isl.3.2.15016  0.784
2011 Jayaram B, Syed I, Kyathanahalli CN, Rhodes CJ, Kowluru A. Arf nucleotide binding site opener [ARNO] promotes sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 β-cells and rat islets. Biochemical Pharmacology. 81: 1016-27. PMID 21276423 DOI: 10.1016/J.Bcp.2011.01.006  0.783
2011 Syed I, Kyathanahalli CN, Kowluru A. Phagocyte-like NADPH oxidase generates ROS in INS 832/13 cells and rat islets: role of protein prenylation. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 300: R756-62. PMID 21228337 DOI: 10.1152/Ajpregu.00786.2010  0.723
2011 Subasinghe W, Syed I, Kowluru A. Phagocyte-like NADPH oxidase promotes cytokine-induced mitochondrial dysfunction in pancreatic β-cells: evidence for regulation by Rac1. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 300: R12-20. PMID 20943855 DOI: 10.1152/Ajpregu.00421.2010  0.667
2010 Kamath V, Kyathanahalli CN, Jayaram B, Syed I, Olson LK, Ludwig K, Klumpp S, Krieglstein J, Kowluru A. Regulation of glucose- and mitochondrial fuel-induced insulin secretion by a cytosolic protein histidine phosphatase in pancreatic beta-cells. American Journal of Physiology. Endocrinology and Metabolism. 299: E276-86. PMID 20501872 DOI: 10.1152/Ajpendo.00091.2010  0.79
2010 Syed I, Jayaram B, Subasinghe W, Kowluru A. Tiam1/Rac1 signaling pathway mediates palmitate-induced, ceramide-sensitive generation of superoxides and lipid peroxides and the loss of mitochondrial membrane potential in pancreatic beta-cells. Biochemical Pharmacology. 80: 874-83. PMID 20493824 DOI: 10.1016/J.Bcp.2010.05.006  0.75
2010 Kowluru A, Veluthakal R, Rhodes CJ, Kamath V, Syed I, Koch BJ. Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells. Diabetes. 59: 967-77. PMID 20071600 DOI: 10.2337/Db09-1334  0.687
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