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Karl A. Werbovetz - Publications

Affiliations: 
Ohio State University, Columbus, Columbus, OH 
Area:
Pharmaceutical Chemistry, Pharmacy, Pharmacology
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Year Citation  Score
2021 Sharma P, LaRosa C, Antwi J, Govindarajan R, Werbovetz KA. Imidazoles as Potential Anticancer Agents: An Update on Recent Studies. Molecules (Basel, Switzerland). 26. PMID 34299488 DOI: 10.3390/molecules26144213  0.327
2021 Abdelhameed A, Feng M, Joice AC, Zywot EM, Jin Y, La Rosa C, Liao X, Meeds HL, Kim Y, Li J, McElroy CA, Wang MZ, Werbovetz KA. Synthesis and Antileishmanial Evaluation of Arylimidamide-Azole Hybrids Containing a Phenoxyalkyl Linker. Acs Infectious Diseases. PMID 33538576 DOI: 10.1021/acsinfecdis.0c00855  0.414
2019 Abdelhameed A, Liao X, McElroy CA, Joice AC, Rakotondraibe L, Li J, Slebodnick C, Guo P, Wilson WD, Werbovetz KA. Synthesis and antileishmanial evaluation of thiazole orange analogs. Bioorganic & Medicinal Chemistry Letters. 126725. PMID 31732409 DOI: 10.1016/J.Bmcl.2019.126725  0.51
2017 Joice AC, Yang S, Farahat AA, Meeds H, Feng M, Li J, Boykin DW, Wang MZ, Werbovetz KA. Antileishmanial Efficacy and Pharmacokinetics of DB766-azole Combinations. Antimicrobial Agents and Chemotherapy. PMID 29061761 DOI: 10.1128/Aac.01129-17  0.306
2016 Zhu X, Farahat AA, Mattamana M, Joice A, Pandharkar T, Holt E, Banerjee M, Gragg JL, Hu L, Kumar A, Yang S, Wang MZ, Boykin DW, Werbovetz KA. Synthesis and pharmacological evaluation of mono-arylimidamides as antileishmanial agents. Bioorganic & Medicinal Chemistry Letters. PMID 27048943 DOI: 10.1016/J.Bmcl.2016.03.082  0.553
2016 Naman CB, Gromovsky AD, Vela CM, Fletcher JN, Gupta G, Varikuti S, Zhu X, Zywot EM, Chai H, Werbovetz KA, Satoskar AR, Kinghorn AD. Antileishmanial and Cytotoxic Activity of Some Highly Oxidized Abietane Diterpenoids from the Bald Cypress, Taxodium distichum. Journal of Natural Products. PMID 26905523 DOI: 10.1021/Acs.Jnatprod.5B01131  0.528
2016 Van Horn KS, Zhu X, Pandharkar T, Yang S, Vesely B, Vanaerschot M, Dujardin JC, Rijal S, Kyle DE, Wang MZ, Werbovetz KA, Manetsch R. Correction to Antileishmanial Activity of a Series of N(2),N(4)-Disubstituted Quinazoline-2,4-diamines. Journal of Medicinal Chemistry. PMID 26754204 DOI: 10.1021/Acs.Jmedchem.5B00981  0.357
2015 Zhu X, Van Horn KS, Barber MM, Yang S, Wang MZ, Manetsch R, Werbovetz KA. SAR refinement of antileishmanial N(2),N(4)-disubstituted quinazoline-2,4-diamines. Bioorganic & Medicinal Chemistry. PMID 25749014 DOI: 10.1016/J.Bmc.2015.02.020  0.447
2014 Pandharkar T, Zhu X, Mathur R, Jiang J, Schmittgen TD, Shaha C, Werbovetz KA. Studies on the antileishmanial mechanism of action of the arylimidamide DB766: azole interactions and role of CYP5122A1. Antimicrobial Agents and Chemotherapy. 58: 4682-9. PMID 24890590 DOI: 10.1128/Aac.02405-14  0.383
2014 Van Horn KS, Zhu X, Pandharkar T, Yang S, Vesely B, Vanaerschot M, Dujardin JC, Rijal S, Kyle DE, Wang MZ, Werbovetz KA, Manetsch R. Antileishmanial activity of a series of N²,N⁴-disubstituted quinazoline-2,4-diamines. Journal of Medicinal Chemistry. 57: 5141-56. PMID 24874647 DOI: 10.1021/Jm5000408  0.501
2014 Werbovetz KA, Riccio ES, Furimsky A, Richard JV, He S, Iyer L, Mirsalis J. Evaluation of Antitrypanosomal Dihydroquinolines for Hepatotoxicity, Mutagenicity, and Methemoglobin Formation In Vitro. International Journal of Toxicology. 33: 282-287. PMID 24819520 DOI: 10.1177/1091581814533971  0.697
2013 Patrick DA, Bakunov SA, Bakunova SM, Jones SK, Wenzler T, Barszcz T, Kumar A, Boykin DW, Werbovetz KA, Brun R, Tidwell RR. Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives. European Journal of Medicinal Chemistry. 67: 310-24. PMID 23871911 DOI: 10.1016/J.Ejmech.2013.06.033  0.492
2013 Patrick DA, Ismail MA, Arafa RK, Wenzler T, Zhu X, Pandharkar T, Jones SK, Werbovetz KA, Brun R, Boykin DW, Tidwell RR. Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives. Journal of Medicinal Chemistry. 56: 5473-94. PMID 23795673 DOI: 10.1021/Jm400508E  0.408
2013 Yi B, Long S, González-Cestari TF, Henderson BJ, Pavlovicz RE, Werbovetz K, Li C, McKay DB. Discovery of benzamide analogs as negative allosteric modulators of human neuronal nicotinic receptors: pharmacophore modeling and structure-activity relationship studies. Bioorganic & Medicinal Chemistry. 21: 4730-43. PMID 23757208 DOI: 10.1016/J.Bmc.2013.03.082  0.4
2013 Soeiro MN, Werbovetz K, Boykin DW, Wilson WD, Wang MZ, Hemphill A. Novel amidines and analogues as promising agents against intracellular parasites: a systematic review. Parasitology. 140: 929-51. PMID 23561006 DOI: 10.1017/S0031182013000292  0.454
2013 Endeshaw M, Zhu X, He S, Pandharkar T, Cason E, Mahasenan KV, Agarwal H, Li C, Munde M, Wilson WD, Bahar M, Doskotch RW, Kinghorn AD, Kaiser M, Brun R, ... ... Werbovetz KA, et al. 8,8-dialkyldihydroberberines with potent antiprotozoal activity. Journal of Natural Products. 76: 311-5. PMID 23167812 DOI: 10.1021/Np300638F  0.642
2012 Banerjee M, Farahat AA, Kumar A, Wenzler T, Brun R, Munde MM, Wilson WD, Zhu X, Werbovetz KA, Boykin DW. Synthesis, DNA binding and antileishmanial activity of low molecular weight bis-arylimidamides. European Journal of Medicinal Chemistry. 55: 449-54. PMID 22840696 DOI: 10.1016/J.Ejmech.2012.06.058  0.465
2012 Reid CS, Farahat AA, Zhu X, Pandharkar T, Boykin DW, Werbovetz KA. Antileishmanial bis-arylimidamides: DB766 analogs modified in the linker region and bis-arylimidamide structure-activity relationships. Bioorganic & Medicinal Chemistry Letters. 22: 6806-10. PMID 22765899 DOI: 10.1016/J.Bmcl.2012.06.037  0.439
2012 Zhu X, Liu Q, Yang S, Parman T, Green CE, Mirsalis JC, de Nazaré Correia Soeiro M, Mello de Souza E, da Silva CF, da Gama Jaen Batista D, Stephens CE, Banerjee M, Farahat AA, Munde M, Wilson WD, ... ... Werbovetz KA, et al. Evaluation of arylimidamides DB1955 and DB1960 as candidates against visceral leishmaniasis and Chagas' disease: in vivo efficacy, acute toxicity, pharmacokinetics, and toxicology studies. Antimicrobial Agents and Chemotherapy. 56: 3690-9. PMID 22508306 DOI: 10.1128/Aac.06404-11  0.362
2012 He S, Dayton A, Kuppusamy P, Werbovetz KA, Drew ME. Induction of oxidative stress in Trypanosoma brucei by the antitrypanosomal dihydroquinoline OSU-40. Antimicrobial Agents and Chemotherapy. 56: 2428-34. PMID 22314522 DOI: 10.1128/Aac.06386-11  0.585
2012 Zhu X, Pandharkar T, Werbovetz K. Identification of New Antileishmanial Leads from Hits Obtained by High-Throughput Screening Antimicrobial Agents and Chemotherapy. 56: 1182-1189. PMID 22143523 DOI: 10.1128/Aac.05412-11  0.484
2011 Salem MM, Capers J, Rito S, Werbovetz KA. Antiparasitic activity of C-geranyl flavonoids from Mimulus bigelovii. Phytotherapy Research : Ptr. 25: 1246-9. PMID 21796699 DOI: 10.1002/Ptr.3404  0.45
2011 Collar CJ, Zhu X, Werbovetz K, Boykin DW, Wilson WD. Molecular factors governing inhibition of arylimidamides against Leishmania: conservative computational modeling to improve chemotherapies. Bioorganic & Medicinal Chemistry. 19: 4552-61. PMID 21741248 DOI: 10.1016/J.Bmc.2011.06.026  0.464
2011 Gershkovich P, Wasan KM, Sivak O, Lysakowski S, Reid C, Premalatha K, Werbovetz KA. Simultaneous determination of a novel antitrypanosomal compound (OSU-36) and its ester derivative (OSU-40) in plasma by HPLC: application to first pharmacokinetic study in rats. Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society For Pharmaceutical Sciences, Sociã©Tã© Canadienne Des Sciences Pharmaceutiques. 14: 36-45. PMID 21501551 DOI: 10.18433/J3Cp4S  0.324
2011 Bahar M, Deng Y, Zhu X, He S, Pandharkar T, Drew ME, Navarro-Vázquez A, Anklin C, Gil RR, Doskotch RW, Werbovetz KA, Kinghorn AD. Potent antiprotozoal activity of a novel semi-synthetic berberine derivative. Bioorganic & Medicinal Chemistry Letters. 21: 2606-10. PMID 21474310 DOI: 10.1016/J.Bmcl.2011.01.101  0.653
2011 Turabekova MA, Vinogradova VI, Werbovetz KA, Capers J, Rasulev BF, Levkovich MG, Rakhimov SB, Abdullaev ND. Structure-activity relationship investigations of leishmanicidal N-benzylcytisine derivatives. Chemical Biology & Drug Design. 78: 183-9. PMID 21457471 DOI: 10.1111/J.1747-0285.2011.01092.X  0.457
2011 Reid CS, Patrick DA, He S, Fotie J, Premalatha K, Tidwell RR, Wang MZ, Liu Q, Gershkovich P, Wasan KM, Wenzler T, Brun R, Werbovetz KA. Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols: Effect of core substitutions and salt formation. Bioorganic & Medicinal Chemistry. 19: 513-23. PMID 21112788 DOI: 10.1016/J.Bmc.2010.11.003  0.704
2010 Endeshaw MM, Li C, de Leon J, Yao N, Latibeaudiere K, Premalatha K, Morrissette N, Werbovetz KA. Synthesis and evaluation of oryzalin analogs against Toxoplasma gondii. Bioorganic & Medicinal Chemistry Letters. 20: 5179-83. PMID 20675138 DOI: 10.1016/J.Bmcl.2010.07.003  0.522
2010 Richard JV, Werbovetz KA. New antileishmanial candidates and lead compounds. Current Opinion in Chemical Biology. 14: 447-55. PMID 20400358 DOI: 10.1016/J.Cbpa.2010.03.023  0.414
2010 Wang MZ, Zhu X, Srivastava A, Liu Q, Sweat JM, Pandharkar T, Stephens CE, Riccio E, Parman T, Munde M, Mandal S, Madhubala R, Tidwell RR, Wilson WD, Boykin DW, ... ... Werbovetz KA, et al. Novel arylimidamides for treatment of visceral leishmaniasis. Antimicrobial Agents and Chemotherapy. 54: 2507-16. PMID 20368397 DOI: 10.1128/Aac.00250-10  0.421
2010 Ma C, Tran J, Gu F, Ochoa R, Li C, Sept D, Werbovetz K, Morrissette N. Dinitroaniline activity in Toxoplasma gondii expressing wild-type or mutant alpha-tubulin. Antimicrobial Agents and Chemotherapy. 54: 1453-60. PMID 20145086 DOI: 10.1128/Aac.01150-09  0.356
2010 Fotie J, Kaiser M, Delfín DA, Manley J, Reid CS, Paris JM, Wenzler T, Maes L, Mahasenan KV, Li C, Werbovetz KA. Antitrypanosomal activity of 1,2-dihydroquinolin-6-ols and their ester derivatives. Journal of Medicinal Chemistry. 53: 966-82. PMID 20047276 DOI: 10.1021/Jm900723W  0.462
2010 Bakunov SA, Bakunova SM, Wenzler T, Ghebru M, Werbovetz KA, Brun R, Tidwell RR. Synthesis and antiprotozoal activity of cationic 1,4-diphenyl-1H-1,2,3-triazoles. Journal of Medicinal Chemistry. 53: 254-72. PMID 19928900 DOI: 10.1021/Jm901178D  0.471
2009 Bakunov SA, Bakunova SM, Bridges AS, Wenzler T, Barszcz T, Werbovetz KA, Brun R, Tidwell RR. Synthesis and antiprotozoal properties of pentamidine congeners bearing the benzofuran motif. Journal of Medicinal Chemistry. 52: 5763-7. PMID 19757840 DOI: 10.1021/Jm9006406  0.452
2009 Bakunova SM, Bakunov SA, Wenzler T, Barszcz T, Werbovetz KA, Brun R, Tidwell RR. Synthesis and antiprotozoal activity of pyridyl analogues of pentamidine. Journal of Medicinal Chemistry. 52: 4657-67. PMID 19606902 DOI: 10.1021/Jm900805V  0.528
2009 Patrick DA, Bakunov SA, Bakunova SM, Kumar EV, Chen H, Jones SK, Wenzler T, Barzcz T, Werbovetz KA, Brun R, Tidwell RR. Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes. European Journal of Medicinal Chemistry. 44: 3543-51. PMID 19409677 DOI: 10.1016/J.Ejmech.2009.03.014  0.533
2009 Bakunova SM, Bakunov SA, Patrick DA, Kumar EV, Ohemeng KA, Bridges AS, Wenzler T, Barszcz T, Jones SK, Werbovetz KA, Brun R, Tidwell RR. Structure-activity study of pentamidine analogues as antiprotozoal agents. Journal of Medicinal Chemistry. 52: 2016-35. PMID 19267462 DOI: 10.1021/Jm801547T  0.527
2009 Delfín DA, Morgan RE, Zhu X, Werbovetz KA. Redox-active dinitrodiphenylthioethers against Leishmania: synthesis, structure-activity relationships and mechanism of action studies. Bioorganic & Medicinal Chemistry. 17: 820-9. PMID 19058972 DOI: 10.1016/J.Bmc.2008.11.031  0.49
2008 Morgan RE, Ahn S, Nzimiro S, Fotie J, Phelps MA, Cotrill J, Yakovich AJ, Sackett DL, Dalton JT, Werbovetz KA. Inhibitors of tubulin assembly identified through screening a compound library. Chemical Biology & Drug Design. 72: 513-24. PMID 19090918 DOI: 10.1111/J.1747-0285.2008.00729.X  0.79
2008 Joshi MS, Bauer JA, Werbovetz KA, Barszcz T, Patil PN. Pharmacological and biological screening of ascorbigen: protection against glucose-induced endothelial cell toxicity. Phytotherapy Research : Ptr. 22: 1581-6. PMID 18844288 DOI: 10.1002/Ptr.2494  0.332
2008 Bakunov SA, Bakunova SM, Wenzler T, Barszcz T, Werbovetz KA, Brun R, Tidwell RR. Synthesis and antiprotozoal activity of cationic 2-phenylbenzofurans. Journal of Medicinal Chemistry. 51: 6927-44. PMID 18841956 DOI: 10.1021/Jm800918V  0.49
2008 Rosypal AC, Werbovetz KA, Salem M, Stephens CE, Kumar A, Boykin DW, Hall JE, Tidwell RR. Inhibition by Dications of in vitro growth of Leishmania major and Leishmania tropica: causative agents of old world cutaneous leishmaniasis. The Journal of Parasitology. 94: 743-9. PMID 18605790 DOI: 10.1645/Ge-1387.1  0.539
2008 Morgan RE, Werbovetz KA. Selective lead compounds against kinetoplastid tubulin. Advances in Experimental Medicine and Biology. 625: 33-47. PMID 18365657 DOI: 10.1007/978-0-387-77570-8_4  0.349
2008 Hu L, Arafa RK, Ismail MA, Wenzler T, Brun R, Munde M, Wilson WD, Nzimiro S, Samyesudhas S, Werbovetz KA, Boykin DW. Azaterphenyl diamidines as antileishmanial agents. Bioorganic & Medicinal Chemistry Letters. 18: 247-51. PMID 18006310 DOI: 10.1016/J.Bmcl.2007.10.091  0.479
2008 Werbovetz K, George T, Richard J, Barszcz T, Capers J. Flavylium Salts as Precursors of Biologically Active Chalcones Letters in Drug Design & Discovery. 5: 69-73. DOI: 10.2174/157018008783406697  0.318
2008 Turabekova MA, Vinogradova VI, Rasulev BF, Levkovich MG, Werbovetz K, Capers J, Abdullaev ND. Antiparasitic activity of certain isoquinoline alkaloids and their hypothetical complexes with oligonucleotides Chemistry of Natural Compounds. 44: 341-345. DOI: 10.1007/S10600-008-9057-4  0.448
2007 Bakunova SM, Bakunov SA, Wenzler T, Barszcz T, Werbovetz KA, Brun R, Hall JE, Tidwell RR. Synthesis and in vitro antiprotozoal activity of bisbenzofuran cations. Journal of Medicinal Chemistry. 50: 5807-23. PMID 17948982 DOI: 10.1021/Jm0708634  0.465
2007 George TG, Endeshaw MM, Morgan RE, Mahasenan KV, Delfín DA, Mukherjee MS, Yakovich AJ, Fotie J, Li C, Werbovetz KA. Synthesis, biological evaluation, and molecular modeling of 3,5-substituted-N1-phenyl-N4,N4-di-n-butylsulfanilamides as antikinetoplastid antimicrotubule agents. Bioorganic & Medicinal Chemistry. 15: 6071-9. PMID 17618122 DOI: 10.1016/J.Bmc.2007.06.042  0.782
2007 Gutteridge CE, Vo JV, Tillett CB, Vigilante JA, Dettmer JR, Patterson SL, Werbovetz KA, Capers J, Nichols DA, Bhattacharjee AK, Gerena L. Antileishmanial and antimalarial chalcones: synthesis, efficacy and cytotoxicity of pyridinyl and naphthalenyl analogs. Medicinal Chemistry (ShäRiqah (United Arab Emirates)). 3: 115-9. PMID 17348849 DOI: 10.2174/157340607780059530  0.525
2007 Gonzalez JL, Stephens CE, Wenzler T, Brun R, Tanious FA, Wilson WD, Barszcz T, Werbovetz KA, Boykin DW. Synthesis and antiparasitic evaluation of bis-2,5-[4-guanidinophenyl]thiophenes. European Journal of Medicinal Chemistry. 42: 552-7. PMID 17178177 DOI: 10.1016/J.Ejmech.2006.11.006  0.352
2006 Salem MM, Werbovetz KA. Natural products from plants as drug candidates and lead compounds against leishmaniasis and trypanosomiasis. Current Medicinal Chemistry. 13: 2571-98. PMID 17017912 DOI: 10.2174/092986706778201611  0.379
2006 Delfín DA, Bhattacharjee AK, Yakovich AJ, Werbovetz KA. Activity of and initial mechanistic studies on a novel antileishmanial agent identified through in silico pharmacophore development and database searching. Journal of Medicinal Chemistry. 49: 4196-207. PMID 16821779 DOI: 10.1021/Jm060156V  0.779
2006 Yakovich AJ, Ragone FL, Alfonzo JD, Sackett DL, Werbovetz KA. Leishmania tarentolae: purification and characterization of tubulin and its suitability for antileishmanial drug screening. Experimental Parasitology. 114: 289-96. PMID 16753146 DOI: 10.1016/J.Exppara.2006.04.008  0.74
2006 George TG, Johnsamuel J, Delfín DA, Yakovich A, Mukherjee M, Phelps MA, Dalton JT, Sackett DL, Kaiser M, Brun R, Werbovetz KA. Antikinetoplastid antimitotic activity and metabolic stability of dinitroaniline sulfonamides and benzamides. Bioorganic & Medicinal Chemistry. 14: 5699-710. PMID 16675220 DOI: 10.1016/J.Bmc.2006.04.017  0.769
2006 Wu D, George TG, Hurh E, Werbovetz KA, Dalton JT. Pre-systemic metabolism prevents in vivo antikinetoplastid activity of N1,N4-substituted 3,5-dinitro sulfanilamide, GB-II-150. Life Sciences. 79: 1081-93. PMID 16643960 DOI: 10.1016/J.Lfs.2006.03.028  0.411
2006 Das U, Gul HI, Alcorn J, Shrivastav A, George T, Sharma RK, Nienaber KH, De Clercq E, Balzarini J, Kawase M, Kan N, Tanaka T, Tani S, Werbovetz KA, Yakovich AJ, et al. Cytotoxic 5-aryl-1-(4-nitrophenyl)-3-oxo-1,4-pentadienes mounted on alicyclic scaffolds. European Journal of Medicinal Chemistry. 41: 577-85. PMID 16581158 DOI: 10.1016/J.Ejmech.2005.12.014  0.789
2006 Li PK, Pandit B, Sackett DL, Hu Z, Zink J, Zhi J, Freeman D, Robey RW, Werbovetz K, Lewis A, Li C. A thalidomide analogue with in vitro antiproliferative, antimitotic, and microtubule-stabilizing activities Molecular Cancer Therapeutics. 5: 450-456. PMID 16505120 DOI: 10.1158/1535-7163.Mct-05-0254  0.401
2006 Werbovetz K. Diamidines as antitrypanosomal, antileishmanial and antimalarial agents. Current Opinion in Investigational Drugs (London, England : 2000). 7: 147-57. PMID 16499285  0.367
2006 Salem MM, Werbovetz KA. Isoflavonoids and other compounds from Psorothamnus arborescens with antiprotozoal activities. Journal of Natural Products. 69: 43-9. PMID 16441066 DOI: 10.1021/Np0502600  0.479
2005 Li PK, Xiao Z, Hu Z, Pandit B, Sun Y, Sackett DL, Werbovetz K, Lewis A, Johnsamuel J. Conformationally restricted analogs of Combretastatin A-4 derived from SU5416. Bioorganic & Medicinal Chemistry Letters. 15: 5382-5. PMID 16213720 DOI: 10.1016/J.Bmcl.2005.09.001  0.48
2005 Salem MM, Werbovetz KA. Antiprotozoal compounds from Psorothamnus polydenius. Journal of Natural Products. 68: 108-11. PMID 15679330 DOI: 10.1021/Np049682K  0.507
2004 Cottrell DM, Capers J, Salem MM, DeLuca-Fradley K, Croft SL, Werbovetz KA. Antikinetoplastid activity of 3-aryl-5-thiocyanatomethyl-1,2,4-oxadiazoles. Bioorganic & Medicinal Chemistry. 12: 2815-24. PMID 15142541 DOI: 10.1016/J.Bmc.2004.03.054  0.524
2004 Bhattacharya G, Herman J, Delfín D, Salem MM, Barszcz T, Mollet M, Riccio G, Brun R, Werbovetz KA. Synthesis and antitubulin activity of N1- and N4-substituted 3,5-dinitro sulfanilamides against African trypanosomes and Leishmania. Journal of Medicinal Chemistry. 47: 1823-32. PMID 15027874 DOI: 10.1021/Jm0304461  0.516
2003 Werbovetz KA, Sackett DL, Delfín D, Bhattacharya G, Salem M, Obrzut T, Rattendi D, Bacchi C. Selective antimicrotubule activity of N1-phenyl-3,5-dinitro-N4,N4-di-n-propylsulfanilamide (GB-II-5) against kinetoplastid parasites. Molecular Pharmacology. 64: 1325-33. PMID 14645662 DOI: 10.1124/Mol.64.6.1325  0.461
2003 Hua DH, Tamura M, Egi M, Werbovetz K, Delfín D, Salem M, Chiang PK. Antiprotozoal activities of symmetrical bishydroxamic acids. Bioorganic & Medicinal Chemistry. 11: 4357-61. PMID 13129572 DOI: 10.1016/S0968-0896(03)00522-4  0.386
2003 Stephens CE, Brun R, Salem MM, Werbovetz KA, Tanious F, Wilson WD, Boykin DW. The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani Bioorganic and Medicinal Chemistry Letters. 13: 2065-2069. PMID 12781196 DOI: 10.1016/S0960-894X(03)00319-6  0.497
2002 Werbovetz KA. Promising therapeutic targets for antileishmanial drugs. Expert Opinion On Therapeutic Targets. 6: 407-22. PMID 12223057 DOI: 10.1517/14728222.6.4.407  0.362
2002 Bhattacharya G, Salem MM, Werbovetz KA. Antileishmanial dinitroaniline sulfonamides with activity against parasite tubulin. Bioorganic & Medicinal Chemistry Letters. 12: 2395-8. PMID 12161141 DOI: 10.1016/S0960-894X(02)00465-1  0.514
2002 Bhattacharjee AK, Skanchy DJ, Jennings B, Hudson TH, Brendle JJ, Werbovetz KA. Analysis of stereoelectronic properties, mechanism of action and pharmacophore of synthetic indolo[2,1-b]quinazoline-6,12-dione derivatives in relation to antileishmanial activity using quantum chemical, cyclic voltammetry and 3-D-QSAR CATALYST procedures. Bioorganic & Medicinal Chemistry. 10: 1979-89. PMID 11937358 DOI: 10.1016/S0968-0896(02)00013-5  0.42
2002 Brendle JJ, Outlaw A, Kumar A, Boykin DW, Patrick DA, Tidwell RR, Werbovetz KA. Antileishmanial activities of several classes of aromatic dications Antimicrobial Agents and Chemotherapy. 46: 797-807. PMID 11850264 DOI: 10.1128/Aac.46.3.797-807.2002  0.533
2000 Havens CG, Bryant N, Asher L, Lamoreaux L, Perfetto S, Brendle JJ, Werbovetz KA. Cellular effects of leishmanial tubulin inhibitors on L. donovani Molecular and Biochemical Parasitology. 110: 223-236. PMID 11071278 DOI: 10.1016/S0166-6851(00)00272-3  0.37
2000 Werbovetz KA, Bhattacharjee AK, Brendle JJ, Scovill JP. Analysis of stereoelectronic properties of camptothecin analogues in relation to biological activity Bioorganic and Medicinal Chemistry. 8: 1741-1747. PMID 10976522 DOI: 10.1016/S0968-0896(00)00111-5  0.428
2000 Werbovetz KA. Target-based drug discovery for malaria, leishmaniasis, and trypanosomiasis. Current Medicinal Chemistry. 7: 835-60. PMID 10828290 DOI: 10.2174/0929867003374615  0.349
1999 Werbovetz KA, Brendle JJ, Sackett DL. Purification, characterization, and drug susceptibility of tubulin from Leishmania Molecular and Biochemical Parasitology. 98: 53-65. PMID 10029309 DOI: 10.1016/S0166-6851(98)00146-7  0.377
1998 Pitzer KK, Werbovetz KA, Brendle JJ, Scovill JP. Synthesis and biological evaluation of 4-chloro-3,5- dinitrobenzotrifluoride analogues as antileishmanial agents Journal of Medicinal Chemistry. 41: 4885-4889. PMID 9822557 DOI: 10.1021/Jm9804073  0.453
1997 Madalengoitia JS, Tepe JJ, Werbovetz KA, Lehnert EK, Macdonald TL. Structure-activity relationship for DNA topoisomerase II-induced DNA cleavage by azatoxin analogues. Bioorganic & Medicinal Chemistry. 5: 1807-15. PMID 9354236 DOI: 10.1016/S0968-0896(97)00113-2  0.371
1996 Werbovetz KA, Bacchi CJ, Englund PT. Trypanocidal analogs of myristate and myristoyllysophosphatidylcholine. Molecular and Biochemical Parasitology. 81: 115-8. PMID 8892311 DOI: 10.1016/0166-6851(96)02708-9  0.303
1994 Doering TL, Lu T, Werbovetz KA, Gokel GW, Hart GW, Gordon JI, Englund PT. Toxicity of myristic acid analogs toward African trypanosomes. Proceedings of the National Academy of Sciences of the United States of America. 91: 9735-9. PMID 7937882 DOI: 10.1073/Pnas.91.21.9735  0.318
1992 Werbovetz KA, Lehnert EK, Macdonald TL, Pearson RD. Cytotoxicity of acridine compounds for Leishmania promastigotes in vitro. Antimicrobial Agents and Chemotherapy. 36: 495-7. PMID 1318684 DOI: 10.1128/Aac.36.2.495  0.499
1991 Huber SK, Werbovetz KA, Obaza-Nutaitis J, Lehnert EK, Macdonald TL. Tubulin binding of conformationally restricted bis-aryl compounds Bioorganic and Medicinal Chemistry Letters. 1: 243-246. DOI: 10.1016/S0960-894X(01)81034-9  0.387
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