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John P. Toscano - Publications

Affiliations: 
Chemistry Johns Hopkins University, Baltimore, MD 
Area:
nanosecond time-resolved infrared (TRIR) spectroscopy
Website:
http://www.chemistry.jhu.edu/Toscano/biography.html

77 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Álvarez L, Suarez Vega V, McGinity C, Khodade VS, Toscano JP, Nagy P, Lin J, Works C, Fukuto JM. The reactions of hydropersulfides (RSSH) with myoglobin. Archives of Biochemistry and Biophysics. 108391. PMID 32360749 DOI: 10.1016/J.Abb.2020.108391  0.332
2019 Keceli G, Majumdar A, Thorpe CN, Jun S, Tocchetti CG, Lee DI, Mahaney JE, Paolocci N, Toscano JP. Nitroxyl (HNO) targets phospholamban cysteines 41 and 46 to enhance cardiac function. The Journal of General Physiology. PMID 30842219 DOI: 10.1085/Jgp.201812208  0.334
2018 Bogdándi V, Ida T, Sutton TR, Bianco C, Ditrói T, Koster G, Henthorn HA, Minnion M, Toscano JP, van der Vliet A, Pluth MD, Feelisch M, Fukuto JM, Akaike T, Nagy P. Speciation of Reactive Sulfur Species and their Reactions with Alkylating Agents: Do we have any clue about what is present inside the cell? British Journal of Pharmacology. PMID 29909607 DOI: 10.1111/Bph.14394  0.351
2017 Keceli G, Majumdar A, Thorpe CN, Mahaney JE, Paolocci N, Toscano JP. HNO Modifies Cysteines 41 and 46 in the Transmembrane Domain of Phospholamban Increasing SERCA2a Activity Free Radical Biology and Medicine. 112: 114-115. DOI: 10.1016/J.Freeradbiomed.2017.10.171  0.311
2017 Khodade VS, Pharoah BM, Toscano JP. Design,Synthesis and Evaluation of Novel Alkyl Persulfide Precursors Free Radical Biology and Medicine. 112: 30. DOI: 10.1016/J.Freeradbiomed.2017.10.034  0.328
2016 Bianco CL, Chavez TA, Sosa V, Saund SS, Nguyen QN, Tantillo DJ, Ichimura AS, Toscano JP, Fukuto JM. The Chemical Biology of the Persulfide (RSSH)/Perthiyl (RSS·) Redox Couple and Possible Role in Biological Redox Signaling. Free Radical Biology & Medicine. PMID 27677567 DOI: 10.1016/J.Freeradbiomed.2016.09.020  0.325
2016 Nourian S, Zilber ZA, Toscano JP. Development of N-Substituted Hydroxamic Acids with Pyrazolone Leaving Groups as Nitrosocarbonyl Precursors. The Journal of Organic Chemistry. PMID 27617912 DOI: 10.1021/Acs.Joc.6B01705  0.343
2016 Bianco CL, Moore CD, Fukuto JM, Toscano JP. Selenols are Resistant to Irreversible Modification by HNO. Free Radical Biology & Medicine. PMID 27424037 DOI: 10.1016/J.Freeradbiomed.2016.07.008  0.319
2016 Chavez TA, Liu Y, Toscano JP. Time-Resolved Infrared (TRIR) Studies of Oxycarbonylnitrenes. The Journal of Organic Chemistry. PMID 27359103 DOI: 10.1021/Acs.Joc.6B00949  0.624
2016 Millikin R, Bianco CL, White C, Saund SS, Henriquez S, Sosa V, Akaike T, Kumagai Y, Soeda S, Toscano JP, Lin J, Fukuto JM. The Chemical Biology of Protein Hydropersulfides: Studies of a Possible Protective Function of Biological Hydropersulfide Generation. Free Radical Biology & Medicine. PMID 27242269 DOI: 10.1016/J.Freeradbiomed.2016.05.013  0.318
2016 Nourian S, Lesko RP, Guthrie DA, Toscano JP. Nitrosocarbonyl release from O-substituted hydroxamic acids with pyrazolone leaving groups Tetrahedron. 72: 6037-6042. DOI: 10.1016/J.Tet.2016.08.016  0.344
2016 Keceli G, Majumdar A, Thorpe CN, Mahaney JE, Paolocci N, Toscano JP. Investigation of HNO-Derived Modifications on Phospholamban Biophysical Journal. 110: 541a. DOI: 10.1016/J.Bpj.2015.11.2895  0.314
2015 Guthrie DA, Ho A, Takahashi CG, Collins A, Morris M, Toscano JP. "Catch-and-release" of HNO with pyrazolones. The Journal of Organic Chemistry. 80: 1338-48. PMID 25594416 DOI: 10.1021/Jo502330W  0.347
2015 Guthrie DA, Nourian S, Takahashi CG, Toscano JP. Curtailing the hydroxylaminobarbituric acid-hydantoin rearrangement to favor HNO generation. The Journal of Organic Chemistry. 80: 1349-56. PMID 25585151 DOI: 10.1021/Jo5023316  0.318
2014 Keceli G, Moore CD, Toscano JP. Comparison of HNO reactivity with tryptophan and cysteine in small peptides. Bioorganic & Medicinal Chemistry Letters. 24: 3710-3. PMID 25080164 DOI: 10.1016/J.Bmcl.2014.07.014  0.301
2014 Ranaweera RA, Scott T, Li Q, Rajam S, Duncan A, Li R, Evans A, Bohne C, Toscano JP, Ault BS, Gudmundsdottir AD. Trans-cis isomerization of vinylketones through triplet 1,2-biradicals. The Journal of Physical Chemistry. A. 118: 10433-47. PMID 25046555 DOI: 10.1021/Jp504174T  0.542
2014 Keceli G, Toscano JP. Reactivity of C-terminal cysteines with HNO. Biochemistry. 53: 3689-98. PMID 24869490 DOI: 10.1021/Bi500360X  0.318
2014 Senadheera SN, Evans AS, Toscano JP, Givens RS. 2-Diazo-1-(4-hydroxyphenyl)ethanone: a versatile photochemical and synthetic reagent. Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society For Photobiology. 13: 324-41. PMID 24305682 DOI: 10.1039/C3Pp50305D  0.546
2013 Keceli G, Moore CD, Labonte JW, Toscano JP. NMR detection and study of hydrolysis of HNO-derived sulfinamides. Biochemistry. 52: 7387-96. PMID 24073927 DOI: 10.1021/Bi401110F  0.337
2013 Cline MR, Chavez TA, Toscano JP. Oxidation of N-hydroxy-l-arginine by hypochlorous acid to form nitroxyl (HNO). Journal of Inorganic Biochemistry. 118: 148-54. PMID 23102772 DOI: 10.1016/J.Jinorgbio.2012.09.024  0.784
2012 Keceli G, Toscano JP. Reactivity of nitroxyl-derived sulfinamides. Biochemistry. 51: 4206-16. PMID 22571165 DOI: 10.1021/Bi300015U  0.336
2012 Liu Y, Evans AS, Toscano JP. Nanosecond time-resolved IR study of thiobenzoylnitrene. Physical Chemistry Chemical Physics : Pccp. 14: 10438-44. PMID 22466449 DOI: 10.1039/C2Cp40327G  0.72
2012 Guthrie DA, Kim NY, Siegler MA, Moore CD, Toscano JP. Development of N-substituted hydroxylamines as efficient nitroxyl (HNO) donors. Journal of the American Chemical Society. 134: 1962-5. PMID 22233148 DOI: 10.1021/Ja2103923  0.327
2012 Sutton AD, Williamson M, Weismiller H, Toscano JP. Optimization of HNO production from N,O-bis-acylated hydroxylamine derivatives. Organic Letters. 14: 472-5. PMID 22196028 DOI: 10.1021/Ol203016C  0.694
2012 Evans AS, Toscano JP. ChemInform Abstract: The Chemistry of NO- and HNO-Producing Diazeniumdiolates Cheminform. 43: no-no. DOI: 10.1002/chin.201246260  0.499
2011 Cline MR, Tu C, Silverman DN, Toscano JP. Detection of nitroxyl (HNO) by membrane inlet mass spectrometry. Free Radical Biology & Medicine. 50: 1274-9. PMID 21349325 DOI: 10.1016/J.Freeradbiomed.2011.02.008  0.77
2011 Evans AS, Cohen AD, Gurard-Levin ZA, Kebede N, Celius TC, Miceli AP, Toscano JP. Photogeneration and reactivity of acyl nitroso compounds Canadian Journal of Chemistry. 89: 130-138. DOI: 10.1139/V10-101  0.466
2011 Cline MR, Toscano JP. Detection of nitroxyl (HNO) by a prefluorescent probe Journal of Physical Organic Chemistry. 24: 993-998. DOI: 10.1002/Poc.1871  0.779
2010 Evans AS, Sundaram GS, Sassmannshausen J, Toscano JP, Tippmann EM. Weinreb amides in carbene chemistry: a time-resolved IR investigation into a potential intramolecular stabilization mechanism. Organic Letters. 12: 4616-9. PMID 20849098 DOI: 10.1021/Ol101946U  0.766
2010 Sivakumaran V, Thorpe C, Keceli G, Toscano JP, Toccetti C, Paolocci N, Mahaney JE. HNO Uncouples PLN from SERCA2a Enhancing Pump Activity Biophysical Journal. 98: 170a. DOI: 10.1016/J.Bpj.2009.12.917  0.302
2010 Evans AS, Toscano JP. The Chemistry of NO- and HNO-Producing Diazeniumdiolates Patai's Chemistry of Functional Groups. DOI: 10.1002/9780470682531.Pat0513  0.593
2009 Thorpe C, De Arras L, Toscano JP, Keceli G, Pavlos C, Paolocci N, Froehlich JP, Mahaney JE. The Role of Phospholamban Cysteines in the Activation of the Cardiac Sarcoplasmic Reticulum Calcium Pump by Nitroxyl Biophysical Journal. 96: 326a. DOI: 10.1016/J.Bpj.2008.12.1638  0.77
2008 Froehlich JP, Mahaney JE, Keceli G, Pavlos CM, Goldstein R, Redwood AJ, Sumbilla C, Lee DI, Tocchetti CG, Kass DA, Paolocci N, Toscano JP. Phospholamban thiols play a central role in activation of the cardiac muscle sarcoplasmic reticulum calcium pump by nitroxyl. Biochemistry. 47: 13150-2. PMID 19053265 DOI: 10.1021/Bi801925P  0.753
2008 Xu H, Reynolds MM, Cook KE, Evans AS, Toscano JP. 2-Hydroxy-5-nitrobenzyl as a diazeniumdiolate protecting group: application in NO-releasing polymers with enhanced biocompatibility. Organic Letters. 10: 4593-6. PMID 18811172 DOI: 10.1021/Ol801883F  0.547
2008 Desikan V, Liu Y, Toscano JP, Jenks WS. Photochemistry of N-acetyl-, N-trifluoroacetyl-, N- mesyl-, and N-tosyldibenzothiophene sulfilimines. The Journal of Organic Chemistry. 73: 4398-414. PMID 18507448 DOI: 10.1021/Jo702654Q  0.637
2007 Desikan V, Liu Y, Toscano JP, Jenks WS. Photochemistry of sulfilimine-based nitrene precursors: generation of both singlet and triplet benzoylnitrene. The Journal of Organic Chemistry. 72: 6848-59. PMID 17685655 DOI: 10.1021/Jo071049R  0.656
2006 Wasylenko WA, Kebede N, Showalter BM, Matsunaga N, Miceli AP, Liu Y, Ryzhkov LR, Hadad CM, Toscano JP. Generation of oxynitrenes and confirmation of their triplet ground states. Journal of the American Chemical Society. 128: 13142-50. PMID 17017794 DOI: 10.1021/Ja062712G  0.759
2006 Zhu Y, Pavlos CM, Toscano JP, Dore TM. 8-Bromo-7-hydroxyquinoline as a photoremovable protecting group for physiological use: mechanism and scope. Journal of the American Chemical Society. 128: 4267-76. PMID 16569001 DOI: 10.1021/Ja0555320  0.783
2005 Pavlos CM, Xu H, Toscano JP. Photosensitive precursors to nitric oxide. Current Topics in Medicinal Chemistry. 5: 637-47. PMID 16101425 DOI: 10.2174/1568026054679326  0.766
2005 Cohen AD, Helgen C, Bochet CG, Toscano JP. The mechanism of photoinduced acylation of amines by N-acyl-5,7-dinitroindoline as determined by time-resolved infrared spectroscopy. Organic Letters. 7: 2845-8. PMID 15987151 DOI: 10.1021/Ol050670F  0.359
2005 Hagen V, Benndorf K, Kaupp UB, Pavlos CM, Xu H, Toscano JP, Hess GP, Gillespie DC, Kim G, Kandler K. Control of Cellular Activity Dynamic Studies in Biology: Phototriggers, Photoswitches and Caged Biomolecules. 155-251. DOI: 10.1002/3527605592.ch4  0.742
2004 Pavlos CM, Xu H, Toscano JP. Controlled photochemical release of nitric oxide from O2-substituted diazeniumdiolates. Free Radical Biology & Medicine. 37: 745-52. PMID 15304250 DOI: 10.1016/J.Freeradbiomed.2004.06.010  0.783
2004 Cohen AD, Showalter BM, Toscano JP. Time-resolved IR detection and study of an iminooxirane intermediate. Organic Letters. 6: 401-3. PMID 14748603 DOI: 10.1021/Ol036327X  0.748
2004 Cooper TM, Blaudeau JP, Hall BC, Rogers JE, McLean DG, Liu Y, Toscano JP. The triplet state of a platinum acetylide chromophore examined by time-resolved infrared spectroscopy and density functional theory Chemical Physics Letters. 400: 239-244. DOI: 10.1016/J.Cplett.2004.10.132  0.642
2003 Pavlos CM, Cohen AD, D'Sa RA, Sunoj RB, Wasylenko WA, Kapur P, Relyea HA, Kumar NA, Hadad CM, Toscano JP. Photochemistry of 1-(N,N-diethylamino)diazen-1-ium-1,2-diolate: an experimental and computational investigation. Journal of the American Chemical Society. 125: 14934-40. PMID 14640671 DOI: 10.1021/Ja034487Y  0.766
2003 D'Sa RA, Wang Y, Ruane PH, Showalter BM, Saavedra JE, Davies KM, Citro ML, Booth MN, Keefer LK, Toscano JP. Preparation and reactivity of O2-sulfonated diazeniumdiolates. The Journal of Organic Chemistry. 68: 656-7. PMID 12530906 DOI: 10.1021/Jo026656N  0.761
2003 Cohen AD, Showalter BM, Brady DA, Kenesky CA, Toscano JP. Time-resolved IR studies of cyclic enone triplet excited states and their reactions with alkenes Physical Chemistry Chemical Physics. 5: 1059-1063. DOI: 10.1039/B209805A  0.763
2003 Pritchina EA, Gritsan NP, Maltsev A, Bally T, Autrey T, Liu Y, Wang Y, Toscano JP. Matrix isolation, time-resolved IR, and computational study of the photochemistry of benzoyl azide Physical Chemistry Chemical Physics. 5: 1010-1018. DOI: 10.1039/B209775C  0.685
2003 Hammad LA, Ruane PH, Kumar NA, Toscano JP, Wenthold PG. The energetics of nitric oxide generation upon protonation of diazeniumdiolates International Journal of Mass Spectrometry. 222: 269-279. DOI: 10.1016/S1387-3806(02)00990-9  0.309
2002 Bushan KM, Xu H, Ruane PH, D'Sa RA, Pavlos CM, Smith JA, Celius TC, Toscano JP. Controlled photochemical release of nitric oxide from O(2)-naphthylmethyl- and O(2)-naphthylallyl-substituted diazeniumdiolates. Journal of the American Chemical Society. 124: 12640-1. PMID 12392393  0.786
2002 Ruane PH, Bushan KM, Pavlos CM, D'Sa RA, Toscano JP. Controlled photochemical release of nitric oxide from O2-benzyl-substituted diazeniumdiolates. Journal of the American Chemical Society. 124: 9806-11. PMID 12175240 DOI: 10.1021/ja026900s  0.791
2002 Moss RA, Zheng F, Fedé JM, Ma Y, Sauers RR, Toscano JP, Showalter BM. Bridgehead carbocations via carbene fragmentation: erasing a 10(10) kinetic preference. Journal of the American Chemical Society. 124: 5258-9. PMID 11996553 DOI: 10.1021/Ja020002E  0.74
2002 Geise CM, Wang Y, Mykhaylova O, Frink BT, Toscano JP, Hadad CM. Computational and experimental studies of the effect of substituents on the singlet-triplet energy gap in phenyl(carbomethoxy)carbene. The Journal of Organic Chemistry. 67: 3079-88. PMID 11975570 DOI: 10.1021/Jo0255330  0.493
2002 Wang Y, Hadad CM, Toscano JP. Solvent dependence of the 2-naphthyl(carbomethoxy)carbene singlet-triplet energy gap. Journal of the American Chemical Society. 124: 1761-7. PMID 11853454 DOI: 10.1021/Ja012139V  0.509
2002 Moss RA, Ma Y, Zheng F, Sauers RR, Bally T, Maltsev A, Toscano JP, Showalter BM. The fragmentation of alkoxychlorocarbenes in hydrocarbon solvents and in low temperature argon matrixes Journal of Physical Chemistry A. 106: 12280-12291. DOI: 10.1021/Jp0217076  0.747
2002 Bushan KM, Xu H, Ruane PH, D'Sa RA, Pavlos CM, Smith JA, Celius TC, Toscano JP. Controlled photochemical release of nitric oxide from O2-naphthylmethyl- and O2-naphthylallyl-substituted diazeniumdiolates Journal of the American Chemical Society. 124: 12640-12641. DOI: 10.1021/ja027957h  0.775
2001 Showalter BM, Datta A, Chowdhury PK, Park J, Bandyopadhyay P, Choudhury PK, Kesavan S, Zeng Y, Kraus GA, Gordon MS, Toscano JP, Petrich JW. Identification of a vibrational frequency corresponding to H-atom translocation in hypericin. Photochemistry and Photobiology. 74: 157-63. PMID 11547549 DOI: 10.1562/0031-8655(2001)074<0157:Ioavfc>2.0.Co;2  0.74
2001 Scaltrito DV, Fry HC, Showalter BM, Thompson DW, Liang HC, Zhang CX, Kretzer RM, Kim E, Toscano JP, Karlin KD, Meyer GJ. Reversible carbon monoxide photodissociation from Cu(I) coordination compounds. Inorganic Chemistry. 40: 4514-5. PMID 11511192 DOI: 10.1021/Ic010684R  0.741
2001 Moss RA, Zheng F, Sauers RR, Toscano JP. The 2-norbornyl cation via the fragmentations of exo- and endo-2-norbornyloxychlorocarbenes: distinction without much difference. Journal of the American Chemical Society. 123: 8109-16. PMID 11506568 DOI: 10.1021/Ja010598Q  0.33
2001 Srinivasan A, Kebede N, Saavedra JE, Nikolaitchik AV, Brady DA, Yourd E, Davies KM, Keefer LK, Toscano JP. Chemistry of the diazeniumdiolates. 3. Photoreactivity. Journal of the American Chemical Society. 123: 5465-72. PMID 11389628 DOI: 10.1021/Ja002898Y  0.352
2000 Moss RA, Johnson LA, Yan S, Toscano JP, Showalter BM. New kinetics methodologies applied to carbene fragmentation reactions [16] Journal of the American Chemical Society. 122: 11256-11257. DOI: 10.1021/Ja002611X  0.705
2000 Showalter BM, Bentz TC, Ryzhkov LR, Hadad CM, Toscano JP. Time-resolved infrared studies of triplet 1,3-cyclopentanediyl Journal of Physical Organic Chemistry. 13: 309-312. DOI: 10.1002/1099-1395(200006)13:6<309::Aid-Poc242>3.0.Co;2-A  0.753
1999 Motschiedler K, Gudmundsdottir A, Toscano JP, Platz M, Garcia-Garibay MA. Excited Precursor Reactivity, Fast 1,2-H Shifts, and Diffusion-Controlled Methanol Insertion in 1,2-Diphenylalkylidenes. The Journal of Organic Chemistry. 64: 5139-5147. PMID 34237870 DOI: 10.1021/jo990172i  0.523
1999 Motschiedler K, Gudmundsdottir A, Toscano JP, Platz M, Garcia-Garibay MA. Excited precursor reactivity, fast 1,2-H shifts, and diffusion- controlled methanol insertion in 1,2-diphenylalkylidenes Journal of Organic Chemistry. 64: 5139-5147. DOI: 10.1021/Jo990172I  0.569
1999 Wang Y, Yuzawa T, Hamaguchi HO, Toscano JP. Time-resolved IR studies of 2-naphthyl(carbomethoxy)carbene: Reactivity and direct experimental estimate of the singlet/triplet energy gap Journal of the American Chemical Society. 121: 2875-2882. DOI: 10.1021/Ja983278O  0.55
1998 Srivastava S, Yourd E, Toscano JP. Structural differences between ππ* and nπ* acetophenone triplet excited states as revealed by time-resolved IR spectroscopy Journal of the American Chemical Society. 120: 6173-6174. DOI: 10.1021/Ja981093B  0.349
1998 Nigam M, Platz MS, Showalter BM, Toscano JP, Johnson R, Abbot SC, Kirchhoff MM. Generation and study of benzylchlorocarbene from a phenanthrene precursor Journal of the American Chemical Society. 120: 8055-8059. DOI: 10.1021/Ja980251W  0.77
1997 Platz MS, Huang H, Ford F, Toscano J. Photochemical rearrangements of diazirines and thermal rearrangements of carbenes Pure and Applied Chemistry. 69: 803-807. DOI: 10.1351/Pac199769040803  0.536
1997 Buterbaugh JS, Toscano JP, Weaver WL, Gord JR, Hadad CM, Gustafson TL, Platz MS. Fluorescence lifetime measurements and spectral analysis of adamantyldiazirine Journal of the American Chemical Society. 119: 3580-3591. DOI: 10.1021/Ja964022Q  0.746
1997 Pezacki JP, Pole DL, Warkentin J, Chen T, Ford F, Toscano JP, Fell J, Platz MS. Laser flash and dual wavelength photolysis of 3,4-diaza-2,2-dimethoxy-1-oxa[4.5]spirooct-3-ene. Migration of hydrogen and carbon in cyclobutylidene and in the excited state of its precursor Journal of the American Chemical Society. 119: 3191-3192. DOI: 10.1021/Ja961933R  0.506
1997 Motschiedler KR, Toscano JP, Garcia-Garibay MA. Arylalkylcarbenes from triplet arylalkyldiazoalkanes Tetrahedron Letters. 38: 949-952. DOI: 10.1016/S0040-4039(96)02487-2  0.386
1996 Robert M, Toscano JP, Platz MS, Abbot SC, Kirchhoff MM, Johnson RP. Laser flash photolysis study of chlorocarbene Journal of Physical Chemistry. 100: 18426-18430. DOI: 10.1021/Jp962333H  0.67
1996 Toscano JP, Platz MS, Nikolaev V, Cao Y, Zimmt MB. The lifetime of formylcarbene determined by transient absorption and transient grating spectroscopy Journal of the American Chemical Society. 118: 3527-3528. DOI: 10.1021/Ja953810X  0.433
1995 Wang JL, Toscano JP, Platz MS, Nikolaev V, Popik V. Dicarbomethoxycarbene. A laser flash photolysis study Journal of the American Chemical Society. 117: 5477-5483. DOI: 10.1021/Ja00125A007  0.444
1995 Toscano JP, Platz MS, Nikolaev V. Lifetimes of simple ketocarbenes Journal of the American Chemical Society. 117: 4712-4713. DOI: 10.1021/Ja00121A032  0.483
1994 Toscano JP, Platz MS, Nikolaev V, Popic V. Carboethoxycarbene. A laser flash photolysis study Journal of the American Chemical Society. 116: 8146-8151.  0.372
1994 Platz MS, Modarelli DA, Morgan S, White WR, Mullins M, Çelebi S, Toscano JP. Lifetimes of alkyl and dialkyl carbenes in solution Progress in Reaction Kinetics. 19: 93-137.  0.662
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