Year |
Citation |
Score |
2024 |
Lyu Y, Yang Y, Talwar V, Lu H, Chen C, Salman S, Wicks EE, Huang TY, Drehmer D, Wang Y, Zuo Q, Datan E, Jackson W, Dordai D, Wang R, ... Semenza GL, et al. Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate histone ubiquitination and transcriptional activation of target genes. Cell Reports. 43: 113972. PMID 38517892 DOI: 10.1016/j.celrep.2024.113972 |
0.814 |
|
2023 |
Gilkes DM, Bajpai S, Wong CC, Chaturvedi P, Hubbi ME, Wirtz D, Semenza GL. Retraction: Procollagen Lysyl Hydroxylase 2 Is Essential for Hypoxia-Induced Breast Cancer Metastasis. Molecular Cancer Research : McR. 21: 1120. PMID 37779464 DOI: 10.1158/1541-7786.MCR-23-0654 |
0.829 |
|
2023 |
Semenza GL. Mechanisms of Breast Cancer Stem Cell Specification and Self-Renewal Mediated by Hypoxia-Inducible Factor 1. Stem Cells Translational Medicine. PMID 37768037 DOI: 10.1093/stcltm/szad061 |
0.453 |
|
2023 |
Semenza GL. Targeting intratumoral hypoxia to enhance anti-tumor immunity. Seminars in Cancer Biology. 96: 5-10. PMID 37717718 DOI: 10.1016/j.semcancer.2023.09.002 |
0.341 |
|
2023 |
Gilkes DM, Bajpai S, Chaturvedi P, Wirtz D, Semenza GL. Withdrawal: Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts. The Journal of Biological Chemistry. 299: 105144. PMID 37586148 DOI: 10.1016/j.jbc.2023.105144 |
0.82 |
|
2023 |
Zhang H, Bosch-Marce M, Shimoda LA, Tan YS, Baek JH, Wesley JB, Gonzalez FJ, Semenza GL. Withdrawal: Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. The Journal of Biological Chemistry. 299: 105125. PMID 37556879 DOI: 10.1016/j.jbc.2023.105125 |
0.66 |
|
2023 |
Zuo Q, Yang Y, Lyu Y, Yang C, Chen C, Salman S, Huang TY, Wicks EE, Jackson W, Datan E, Qin W, Semenza GL. Plexin-B3 expression stimulates MET signaling, breast cancer stem cell specification, and lung metastasis. Cell Reports. 42: 112164. PMID 36857181 DOI: 10.1016/j.celrep.2023.112164 |
0.843 |
|
2022 |
Yang Y, Chen C, Zuo Q, Lu H, Salman S, Lyu Y, Huang TY, Wicks EE, Jackson W, Datan E, Wang R, Wang Y, Le N, Zhu Y, Qin W, ... Semenza GL, et al. NARF is a hypoxia-induced coactivator for OCT4-mediated breast cancer stem cell specification. Science Advances. 8: eabo5000. PMID 36490339 DOI: 10.1126/sciadv.abo5000 |
0.853 |
|
2022 |
Poll SR, Martin R, Wohler E, Partan ES, Walek E, Salman S, Groepper D, Kratz L, Cernach M, Jesus-Garcia R, Haldeman-Englert C, Choi YJ, Morris CD, Cohen B, Hoover-Fong J, ... ... Semenza GL, et al. Disruption of the HIF-1 pathway in individuals with Ollier disease and Maffucci syndrome. Plos Genetics. 18: e1010504. PMID 36480544 DOI: 10.1371/journal.pgen.1010504 |
0.282 |
|
2022 |
Koyasu S, Horita S, Saito K, Kobayashi M, Ishikita H, Chow CC, Kambe G, Nishikawa S, Menju T, Morinibu A, Okochi Y, Tabuchi Y, Onodera Y, Takeda N, Date H, ... Semenza GL, et al. ZBTB2 links p53 deficiency to HIF-1-mediated hypoxia signaling to promote cancer aggressiveness. Embo Reports. e202154042. PMID 36341521 DOI: 10.15252/embr.202154042 |
0.71 |
|
2022 |
Semenza GL. Regulation of Erythropoiesis by the Hypoxia-Inducible Factor Pathway: Effects of Genetic and Pharmacological Perturbations. Annual Review of Medicine. PMID 35773226 DOI: 10.1146/annurev-med-042921-102602 |
0.42 |
|
2022 |
Semenza GL. Hypoxia-inducible factors: roles in cardiovascular disease progression, prevention, and treatment. Cardiovascular Research. PMID 35687650 DOI: 10.1093/cvr/cvac089 |
0.366 |
|
2022 |
Qin Y, Dinabandhu A, Cao X, Sanchez JC, Jee K, Rodrigues M, Guo C, Zhang J, Vancel J, Menon D, Khan NS, Ma T, Tzeng SY, Daoud YJ, Green JJ, ... Semenza GL, et al. ANGPTL4 influences the therapeutic response of neovascular age-related macular degeneration patients by promoting choroidal neovascularization. Jci Insight. PMID 35653189 DOI: 10.1172/jci.insight.157896 |
0.332 |
|
2022 |
Wicks EE, Semenza GL. Hypoxia-inducible factors: cancer progression and clinical translation. The Journal of Clinical Investigation. 132. PMID 35642641 DOI: 10.1172/JCI159839 |
0.508 |
|
2022 |
Salman S, Meyers DJ, Wicks EE, Lee SN, Datan E, Thomas AM, Anders NM, Hwang Y, Lyu Y, Yang Y, Jackson W, Dordai D, Rudek MA, Semenza GL. HIF inhibitor 32-134D eradicates murine hepatocellular carcinoma in combination with anti-PD1 therapy. The Journal of Clinical Investigation. 132. PMID 35499076 DOI: 10.1172/JCI156774 |
0.792 |
|
2022 |
Jiang X, Tian W, Kim D, McQuiston AS, Vinh R, Rockson SG, Semenza GL, Nicolls MR. Hypoxia and Hypoxia-Inducible Factors in Lymphedema. Frontiers in Pharmacology. 13: 851057. PMID 35450048 DOI: 10.3389/fphar.2022.851057 |
0.316 |
|
2022 |
Samanta D, Park Y, Andrabi SA, Shelton LM, Gilkes DM, Semenza GL. Correction: PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis. Cancer Research. 82: 1153. PMID 35288733 DOI: 10.1158/0008-5472.CAN-21-4328 |
0.813 |
|
2022 |
Gilkes DM, Chaturvedi P, Bajpai S, Wong CC, Wei H, Pitcairn S, Hubbi ME, Wirtz D, Semenza GL. Editor's Note: Collagen Prolyl Hydroxylases Are Essential for Breast Cancer Metastasis. Cancer Research. 82: 943. PMID 35247897 DOI: 10.1158/0008-5472.CAN-21-4312 |
0.813 |
|
2022 |
Yang Y, Lu H, Chen C, Lyu Y, Cole RN, Semenza GL. HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase II and activate target gene transcription in response to hypoxia. Nature Communications. 13: 316. PMID 35031618 DOI: 10.1038/s41467-021-27944-8 |
0.429 |
|
2021 |
Casadevall A, Jackson S, Semenza GL, Tomaselli GF, Ahima RS. The Journal of Clinical Investigation in the time of COVID-19. The Journal of Clinical Investigation. 131. PMID 34907915 DOI: 10.1172/JCI156409 |
0.213 |
|
2021 |
Liu X, Xie P, Hao N, Zhang M, Liu Y, Liu P, Semenza GL, He J, Zhang H. HIF-1-regulated expression of calreticulin promotes breast tumorigenesis and progression through Wnt/β-catenin pathway activation. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34706936 DOI: 10.1073/pnas.2109144118 |
0.494 |
|
2021 |
Semenza GL. Heritable disorders of oxygen sensing. American Journal of Medical Genetics. Part A. 185: 3334-3339. PMID 34655169 DOI: 10.1002/ajmg.a.62521 |
0.395 |
|
2021 |
Lu H, Lyu Y, Tran L, Lan J, Xie Y, Yang Y, Murugan NL, Wang YJ, Semenza GL. HIF-1 recruits NANOG as a coactivator for TERT gene transcription in hypoxic breast cancer stem cells. Cell Reports. 36: 109757. PMID 34592152 DOI: 10.1016/j.celrep.2021.109757 |
0.485 |
|
2021 |
Wang Y, Lyu Y, Tu K, Xu Q, Yang Y, Salman S, Le N, Lu H, Chen C, Zhu Y, Wang R, Liu Q, Semenza GL. Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization. Science Advances. 7. PMID 34452909 DOI: 10.1126/sciadv.abe3771 |
0.525 |
|
2021 |
Semenza GL. Breakthrough Science: Hypoxia-Inducible Factors, Oxygen Sensing, and Disorders of Hematopoiesis. Blood. PMID 34411243 DOI: 10.1182/blood.2021011043 |
0.411 |
|
2021 |
Zhang J, Qin Y, Martinez M, Flores-Bellver M, Rodrigues M, Dinabandhu A, Cao X, Deshpande M, Qin Y, Aparicio-Domingo S, Rui Y, Tzeng SY, Salman S, Yuan J, Scott AW, ... ... Semenza GL, et al. HIF-1α and HIF-2α redundantly promote retinal neovascularization in patients with ischemic retinal disease. The Journal of Clinical Investigation. 131. PMID 34128478 DOI: 10.1172/JCI139202 |
0.407 |
|
2021 |
Semenza GL. Heritable disorders of oxygen sensing. American Journal of Medical Genetics. Part A. PMID 33973706 DOI: 10.1002/ajmg.a.62250 |
0.395 |
|
2021 |
Wang R, Godet I, Yang Y, Salman S, Lu H, Lyu Y, Zuo Q, Wang Y, Zhu Y, Chen C, He J, Gilkes DM, Semenza GL. Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33952697 DOI: 10.1073/pnas.2020490118 |
0.845 |
|
2021 |
Hu K, Babapoor-Farrokhran S, Rodrigues M, Deshpande M, Puchner B, Kashiwabuchi F, Hassan SJ, Asnaghi L, Handa JT, Merbs S, Eberhart CG, Semenza GL, Montaner S, Sodhi A. Correction: Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma. Oncotarget. 12: 519-520. PMID 33747364 DOI: 10.18632/oncotarget.27780 |
0.384 |
|
2021 |
Semenza GL. Intratumoral Hypoxia and Mechanisms of Immune Evasion Mediated by Hypoxia-Inducible Factors. Physiology (Bethesda, Md.). 36: 73-83. PMID 33595388 DOI: 10.1152/physiol.00034.2020 |
0.443 |
|
2021 |
Lu H, Chen I, Shimoda LA, Park Y, Zhang C, Tran L, Zhang H, Semenza GL. Chemotherapy-Induced Ca Release Stimulates Breast Cancer Stem Cell Enrichment. Cell Reports. 34: 108605. PMID 33406433 DOI: 10.1016/j.celrep.2020.108605 |
0.376 |
|
2021 |
Liu Z, Sun L, Cai Y, Shen S, Zhang T, Wang N, Wu G, Ma W, Li ST, Suo C, Hao Y, Jia WD, Semenza GL, Gao P, Zhang H. Hypoxia-induced suppression of alternative splicing of MBD2 promotes breast cancer metastasis via activation of FZD1. Cancer Research. PMID 33402389 DOI: 10.1158/0008-5472.CAN-20-2876 |
0.488 |
|
2020 |
Wang N, Shi XF, Khan SA, Wang B, Semenza GL, Prabhakar NR, Nanduri J. Hypoxia inducible factor-1 mediates pancreatic β-cell dysfunction by intermittent hypoxia. American Journal of Physiology. Cell Physiology. PMID 32936698 DOI: 10.1152/Ajpcell.00309.2020 |
0.481 |
|
2020 |
Samanta D, Huang TY, Shah R, Yang Y, Pan F, Semenza GL. BIRC2 Expression Impairs Anti-Cancer Immunity and Immunotherapy Efficacy. Cell Reports. 32: 108073. PMID 32846130 DOI: 10.1016/J.Celrep.2020.108073 |
0.492 |
|
2020 |
Jiang X, Tian W, Granucci EJ, Tu AB, Kim D, Dahms P, Pasupneti S, Peng G, Kim Y, Lim AH, Espinoza FH, Cribb M, Dixon JB, Rockson SG, Semenza GL, et al. Decreased lymphatic HIF-2α accentuates lymphatic remodeling in lymphedema. The Journal of Clinical Investigation. PMID 32673288 DOI: 10.1172/Jci136164 |
0.507 |
|
2020 |
Pasupneti S, Tian W, Tu AB, Dahms P, Granucci E, Gandjeva A, Xiang M, Butcher E, Semenza GL, Tuder R, Jiang X, Nicolls MR. Endothelial HIF-2α as a Key Endogenous Mediator Preventing Emphysema. American Journal of Respiratory and Critical Care Medicine. PMID 32515984 DOI: 10.1164/Rccm.202001-0078Oc |
0.482 |
|
2020 |
Lu H, Xie Y, Tran L, Lan J, Yang Y, Murugan NL, Wang R, Wang YJ, Semenza GL. Chemotherapy-induced S100A10 recruits KDM6A to facilitate OCT4-mediated breast cancer stemness. The Journal of Clinical Investigation. PMID 32427586 DOI: 10.1172/Jci138577 |
0.577 |
|
2020 |
Semenza GL. The Genomics and Genetics of Oxygen Homeostasis. Annual Review of Genomics and Human Genetics. PMID 32255719 DOI: 10.1146/Annurev-Genom-111119-073356 |
0.498 |
|
2020 |
Ahima RS, Jackson S, Casadevall A, Semenza GL, Tomaselli G, Collins KL, Lieberman AP, Martin DM, Reddy P. Changing the editorial process at JCI and JCI Insight in response to the COVID-19 pandemic. The Journal of Clinical Investigation. PMID 32202513 DOI: 10.1172/Jci138305 |
0.302 |
|
2019 |
Bohuslavova R, Cerychova R, Papousek F, Olejnickova V, Bartos M, Görlach A, Kolar F, Sedmera D, Semenza GL, Pavlinkova G. HIF-1α is required for development of the sympathetic nervous system. Proceedings of the National Academy of Sciences of the United States of America. PMID 31196952 DOI: 10.1073/Pnas.1903510116 |
0.449 |
|
2019 |
Dabral S, Muecke C, Valasarajan C, Schmoranzer M, Wietelmann A, Semenza GL, Meister M, Muley T, Seeger-Nukpezah T, Samakovlis C, Weissmann N, Grimminger F, Seeger W, Savai R, Pullamsetti SS. A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension. Nature Communications. 10: 2130. PMID 31086178 DOI: 10.1038/S41467-019-10044-Z |
0.538 |
|
2019 |
Casadevall A, Semenza GL, Jackson S, Tomaselli G, Ahima RS. Reducing bias: accounting for the order of co-first authors. The Journal of Clinical Investigation. 130. PMID 31033485 DOI: 10.1172/Jci128764 |
0.328 |
|
2019 |
Xiang L, Semenza GL. Hypoxia-inducible factors promote breast cancer stem cell specification and maintenance in response to hypoxia or cytotoxic chemotherapy. Advances in Cancer Research. 141: 175-212. PMID 30691683 DOI: 10.1016/Bs.Acr.2018.11.001 |
0.586 |
|
2019 |
Xiang L, Mou J, Shao B, Wei Y, Liang H, Takano N, Semenza GL, Xie G. Glutaminase 1 expression in colorectal cancer cells is induced by hypoxia and required for tumor growth, invasion, and metastatic colonization. Cell Death & Disease. 10: 40. PMID 30674873 DOI: 10.1038/S41419-018-1291-5 |
0.544 |
|
2019 |
Semenza GL. Pharmacologic Targeting of Hypoxia-Inducible Factors. Annual Review of Pharmacology and Toxicology. 59: 379-403. PMID 30625281 DOI: 10.1146/Annurev-Pharmtox-010818-021637 |
0.515 |
|
2019 |
Sadek HA, Semenza GL. Editorial overview: Hypoxia Current Opinion in Physiology. 7: iii-v. DOI: 10.1016/J.Cophys.2019.02.002 |
0.46 |
|
2018 |
Jiang X, Tian W, Tu AB, Pasupneti S, Shuffle E, Dahms P, Zhang P, Cai H, Dinh TT, Liu B, Cain C, Giaccia AJ, Butcher EC, Simon C, Semenza GL, et al. Endothelial HIF-2α is Required for the Maintenance of Airway Microvasculature. Circulation. PMID 30586708 DOI: 10.1161/Circulationaha.118.036157 |
0.48 |
|
2018 |
Lan J, Lu H, Samanta D, Salman S, Lu Y, Semenza GL. Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment. Proceedings of the National Academy of Sciences of the United States of America. PMID 30242135 DOI: 10.1073/Pnas.1809695115 |
0.602 |
|
2018 |
Samanta D, Semenza GL. Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors. Biochimica Et Biophysica Acta. PMID 30006019 DOI: 10.1016/J.Bbcan.2018.07.002 |
0.511 |
|
2018 |
Lu H, Tran L, Park Y, Chen I, Lan J, Xie Y, Semenza GL. Reciprocally Regulation of DUSP9 and DUSP16 Expression by HIF-1 Controls ERK and p38 MAP Kinase Activity and Mediates Chemotherapy-Induced Breast Cancer Stem Cell Enrichment. Cancer Research. PMID 29880481 DOI: 10.1158/0008-5472.Can-18-0270 |
0.563 |
|
2018 |
Bao L, Chen Y, Lai HT, Wu SY, Wang JE, Hatanpaa KJ, Raisanen JM, Fontenot M, Lega B, Chiang CM, Semenza GL, Wang Y, Luo W. Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration. Nucleic Acids Research. PMID 29860315 DOI: 10.1093/Nar/Gky449 |
0.745 |
|
2018 |
Li J, Yang Q, Bai Z, Semenza GL, Ge RL. Chronic cold exposure results in subcutaneous adipose tissue browning and altered global metabolism in Qinghai-Tibetan plateau pika (Ochotona curzoniae). Biochemical and Biophysical Research Communications. PMID 29626477 DOI: 10.1016/J.Bbrc.2018.03.147 |
0.399 |
|
2018 |
Samanta D, Park Y, Ni X, Li H, Zahnow CA, Gabrielson E, Pan F, Semenza GL. Chemotherapy induces enrichment of CD47+/CD73+/PDL1+ immune evasive triple-negative breast cancer cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 29367423 DOI: 10.1073/Pnas.1718197115 |
0.492 |
|
2018 |
Semenza GL, Prabhakar NR. The role of hypoxia-inducible factors in carotid body (patho) physiology. The Journal of Physiology. PMID 29359806 DOI: 10.1113/Jp275696 |
0.509 |
|
2018 |
Samanta D, Semenza GL. In Vitro Assays of Breast Cancer Stem Cells. Methods in Molecular Biology (Clifton, N.J.). 1742: 237-246. PMID 29330805 DOI: 10.1007/978-1-4939-7665-2_21 |
0.506 |
|
2018 |
Bao L, Chen Y, Lai H, Chiang C, Semenza GL, Wang Y, Luo W. Abstract 5427: Inhibition of hypoxia-inducible factor 1 (HIF-1) transcriptional activity and cell mobility via G9a/GLP-mediated methylation of HIF-1α Cancer Research. 78: 5427-5427. DOI: 10.1158/1538-7445.Am2018-5427 |
0.752 |
|
2017 |
Fu C, Tyagi R, Chin AC, Rojas T, Li RJ, Guha P, Bernstein IA, Rao F, Xu R, Cha JY, Xu J, Snowman AM, Semenza GL, Snyder SH. Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation. Circulation Research. PMID 29279301 DOI: 10.1161/Circresaha.117.311983 |
0.687 |
|
2017 |
Nanduri J, Peng YJ, Wang N, Khan SA, Semenza GL, Prabhakar NR. DNA methylation in the central and efferent limbs of the chemo reflex requires carotid body neural activity. The Journal of Physiology. PMID 29148180 DOI: 10.1113/Jp274833 |
0.406 |
|
2017 |
Applewhite BP, Babapoor-Farrokhran S, Poon D, Hassan SJ, Wellmann E, Ying HS, Semenza GL, Montaner S, Sodhi A. Lack of Evidence for Vasoactive and Inflammatory Mediators in the Promotion of Macular Edema Associated with Epiretinal Membranes. Scientific Reports. 7: 10608. PMID 28878218 DOI: 10.1038/S41598-017-08997-6 |
0.388 |
|
2017 |
Meng Q, Qin Y, Deshpande M, Kashiwabuchi F, Rodrigues M, Lu Q, Ren H, Elisseeff JH, Semenza GL, Montaner SV, Sodhi A. Hypoxia-Inducible Factor-Dependent Expression of Angiopoietin-Like 4 by Conjunctival Epithelial Cells Promotes the Angiogenic Phenotype of Pterygia. Investigative Ophthalmology & Visual Science. 58: 4514-4523. PMID 28873177 DOI: 10.1167/Iovs.17-21974 |
0.524 |
|
2017 |
Nanduri J, Semenza GL, Prabhakar NR. Epigenetic Changes by DNA methylation in Chronic and Intermittent Hypoxia. American Journal of Physiology. Lung Cellular and Molecular Physiology. ajplung.00325.2017. PMID 28839104 DOI: 10.1152/Ajplung.00325.2017 |
0.437 |
|
2017 |
Jee K, Rodrigues M, Kashiwabuchi F, Applewhite BP, Han I, Lutty G, Goldberg MF, Semenza GL, Montaner S, Sodhi A. Expression of the angiogenic mediator, angiopoietin-like 4, in the eyes of patients with proliferative sickle retinopathy. Plos One. 12: e0183320. PMID 28832635 DOI: 10.1371/Journal.Pone.0183320 |
0.431 |
|
2017 |
Semenza GL. Next-gen cancer research. Journal of Molecular Medicine (Berlin, Germany). 95: 789. PMID 28707082 DOI: 10.1007/S00109-017-1567-8 |
0.411 |
|
2017 |
Samanta D, Semenza GL. Maintenance of redox homeostasis by hypoxia-inducible factors. Redox Biology. 13: 331-335. PMID 28624704 DOI: 10.1016/J.Redox.2017.05.022 |
0.438 |
|
2017 |
Pang Y, Yang C, Schovanek J, Wang H, Bullova P, Caisova V, Gupta G, Wolf KI, Semenza GL, Zhuang Z, Pacak K. Anthracyclines suppress pheochromocytoma cell characteristics, including metastasis, through inhibition of the hypoxia signaling pathway. Oncotarget. 8: 22313-22324. PMID 28423608 DOI: 10.18632/Oncotarget.16224 |
0.541 |
|
2017 |
Semenza GL. A Compendium of Proteins that Interact with HIF-1α. Experimental Cell Research. PMID 28336293 DOI: 10.1016/J.Yexcr.2017.03.041 |
0.493 |
|
2017 |
Lu H, Chen I, Shimoda LA, Park Y, Zhang C, Tran L, Zhang H, Semenza GL. Chemotherapy-Induced Ca(2+) Release Stimulates Breast Cancer Stem Cell Enrichment. Cell Reports. 18: 1946-1957. PMID 28228260 DOI: 10.1016/J.Celrep.2017.02.001 |
0.568 |
|
2017 |
Samanta D, Prabhakar NR, Semenza GL. Systems biology of oxygen homeostasis. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. PMID 28221004 DOI: 10.1002/Wsbm.1382 |
0.432 |
|
2017 |
Ju JA, Godet I, Ye IC, Byun J, Jayatilaka H, Lee SJ, Xiang L, Samanta D, Lee MH, Wu PH, Wirtz D, Semenza GL, Gilkes DM. Hypoxia Selectively Enhances Integrin Receptor Expression to Promote Metastasis. Molecular Cancer Research : McR. PMID 28213554 DOI: 10.1158/1541-7786.Mcr-16-0338 |
0.841 |
|
2017 |
Peng YJ, Zhang X, Gridina A, Chupikova I, McCormick DL, Thomas RJ, Scammell TE, Kim G, Vasavda C, Nanduri J, Kumar GK, Semenza GL, Snyder SH, Prabhakar NR. Complementary roles of gasotransmitters CO and H2S in sleep apnea. Proceedings of the National Academy of Sciences of the United States of America. PMID 28115703 DOI: 10.1073/Pnas.1620717114 |
0.334 |
|
2017 |
Semenza G. 2017 SfRBM Discovery Award Lecture Maintenance Of Oxygen And Redox Homeostasis By Hypoxia-Inducible Factor 1 Free Radical Biology and Medicine. 112: 14. DOI: 10.1016/J.Freeradbiomed.2017.10.367 |
0.553 |
|
2016 |
Schito L, Semenza GL. Hypoxia-Inducible Factors: Master Regulators of Cancer Progression. Trends in Cancer. 2: 758-770. PMID 28741521 DOI: 10.1016/J.Trecan.2016.10.016 |
0.814 |
|
2016 |
Semenza GL. Hypoxia-inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype. The Embo Journal. PMID 28007895 DOI: 10.15252/Embj.201695204 |
0.551 |
|
2016 |
Zeng M, Shen J, Liu Y, Lu LY, Ding K, Fortmann SD, Khan M, Wang J, Hackett SF, Semenza GL, Campochiaro PA. The HIF-1 antagonist acriflavine: visualization in retina and suppression of ocular neovascularization. Journal of Molecular Medicine (Berlin, Germany). PMID 28004126 DOI: 10.1007/S00109-016-1498-9 |
0.397 |
|
2016 |
Rodrigues M, Kashiwabuchi F, Deshpande M, Jee K, Goldberg MF, Lutty G, Semenza GL, Montaner S, Sodhi A. Expression Pattern of HIF-1α and VEGF Supports Circumferential Application of Scatter Laser for Proliferative Sickle Retinopathy. Investigative Ophthalmology & Visual Science. 57: 6739-6746. PMID 27951596 DOI: 10.1167/Iovs.16-19513 |
0.442 |
|
2016 |
Samanta D, Semenza GL. Serine Synthesis Helps Hypoxic Cancer Stem Cells Regulate Redox. Cancer Research. PMID 27811150 DOI: 10.1158/0008-5472.Can-16-1730 |
0.533 |
|
2016 |
Semenza GL. Serendipity, Generosity, and Inspiration. Cell. PMID 27634321 DOI: 10.1016/J.Cell.2016.08.045 |
0.308 |
|
2016 |
Kaelin WG, Ratcliffe PJ, Semenza GL. Pathways for Oxygen Regulation and Homeostasis: The 2016 Albert Lasker Basic Medical Research Award. Jama. PMID 27622845 DOI: 10.1001/Jama.2016.12386 |
0.652 |
|
2016 |
Zhang C, Zhi WI, Lu H, Samanta D, Chen I, Gabrielson E, Semenza GL. Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cells. Oncotarget. PMID 27590511 DOI: 10.18632/Oncotarget.11743 |
0.592 |
|
2016 |
Elgogary A, Xu Q, Poore B, Alt J, Zimmermann SC, Zhao L, Fu J, Chen B, Xia S, Liu Y, Neisser M, Nguyen C, Lee R, Park JK, Reyes J, ... ... Semenza GL, et al. Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 27559084 DOI: 10.1073/Pnas.1611406113 |
0.409 |
|
2016 |
Yuan G, Peng YJ, Khan SA, Nanduri J, Singh A, Vasavda C, Semenza GL, Kumar GK, Snyder SH, Prabhakar NR. H2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea. Science Signaling. 9: ra80. PMID 27531649 DOI: 10.1126/Scisignal.Aaf3204 |
0.407 |
|
2016 |
Nanduri J, Peng YJ, Wang N, Khan SA, Semenza GL, Kumar GK, Prabhakar NR. Epigenetic regulation of redox state mediates persistent cardiorespiratory abnormalities after long-term intermittent hypoxia. The Journal of Physiology. PMID 27506145 DOI: 10.1113/Jp272346 |
0.41 |
|
2016 |
Wang GL, Semenza GL. Oxygen sensing and response to hypoxia by mammalian cells. Redox Report : Communications in Free Radical Research. 2: 89-96. PMID 27405946 DOI: 10.1080/13510002.1996.11747034 |
0.53 |
|
2016 |
Samanta D, Park Y, Andrabi SA, Shelton LM, Gilkes DM, Semenza GL. PHGDH Expression is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance and Lung Metastasis. Cancer Research. PMID 27280394 DOI: 10.1158/0008-5472.Can-16-0530 |
0.842 |
|
2016 |
Bullen JW, Tchernyshyov I, Holewinski RJ, DeVine L, Wu F, Venkatraman V, Kass DL, Cole RN, Van Eyk J, Semenza GL. Protein kinase A-dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1. Science Signaling. 9: ra56. PMID 27245613 DOI: 10.1126/Scisignal.Aaf0583 |
0.536 |
|
2016 |
Zhang C, Samanta D, Lu H, Bullen JW, Zhang H, Chen I, He X, Semenza GL. Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA. Proceedings of the National Academy of Sciences of the United States of America. PMID 27001847 DOI: 10.1073/Pnas.1602883113 |
0.587 |
|
2016 |
Klionsky DJ, Abdelmohsen K, Abe A, Abedin J, Abeliovich H, Arozena AA, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Semenza GL, et al. Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 Autophagy. 12: 443-443. PMID 26902590 DOI: 10.1080/15548627.2016.1147886 |
0.75 |
|
2016 |
Luo W, Chen I, Chen Y, Alkam D, Wang Y, Semenza GL. PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia. Oncotarget. PMID 26837221 DOI: 10.18632/Oncotarget.7142 |
0.756 |
|
2016 |
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... Semenza GL, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356 |
0.772 |
|
2016 |
Semenza GL. Novel strategies for cancer therapy. Journal of Molecular Medicine (Berlin, Germany). 94: 119-20. PMID 26780330 DOI: 10.1007/S00109-016-1379-2 |
0.409 |
|
2016 |
Hu K, Babapoor-Farrokhran S, Rodrigues M, Deshpande M, Puchner B, Kashiwabuchi F, Hassan SJ, Asnaghi L, Handa JT, Merbs S, Eberhart CG, Semenza GL, Montaner S, Sodhi A. Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma. Oncotarget. PMID 26761211 DOI: 10.18632/Oncotarget.6868 |
0.511 |
|
2016 |
Semenza GL, Ruvolo PP. Introduction to tumor microenvironment regulation of cancer cell survival, metastasis, inflammation, and immune surveillance. Biochimica Et Biophysica Acta. 1863: 379-81. PMID 26721622 DOI: 10.1016/J.Bbamcr.2015.12.015 |
0.463 |
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2016 |
Johns RA, Takimoto E, Meuchel LW, Elsaigh E, Zhang A, Heller NM, Semenza GL, Yamaji-Kegan K. Hypoxia-Inducible Factor 1α Is a Critical Downstream Mediator for Hypoxia-Induced Mitogenic Factor (FIZZ1/RELMα)-Induced Pulmonary Hypertension. Arteriosclerosis, Thrombosis, and Vascular Biology. 36: 134-44. PMID 26586659 DOI: 10.1161/Atvbaha.115.306710 |
0.464 |
|
2016 |
Semenza GL. Dynamic regulation of stem cell specification and maintenance by hypoxia-inducible factors. Molecular Aspects of Medicine. 47: 15-23. PMID 26549347 DOI: 10.1016/j.mam.2015.09.004 |
0.417 |
|
2016 |
Prabhakar NR, Semenza GL. Regulation of carotid body oxygen sensing by hypoxia-inducible factors. PflüGers Archiv : European Journal of Physiology. 468: 71-5. PMID 26265380 DOI: 10.1007/S00424-015-1719-Z |
0.473 |
|
2016 |
Semenza GL. The hypoxic tumor microenvironment: A driving force for breast cancer progression. Biochimica Et Biophysica Acta. 1863: 382-91. PMID 26079100 DOI: 10.1016/J.Bbamcr.2015.05.036 |
0.583 |
|
2016 |
Semenza GL. Targeting hypoxia-inducible factor 1 to stimulate tissue vascularization. Journal of Investigative Medicine : the Official Publication of the American Federation For Clinical Research. 64: 361-3. PMID 25955799 DOI: 10.1097/Jim.0000000000000206 |
0.518 |
|
2016 |
Zhi W, Huang C, Gabrielson E, Tully E, Cimino-Mathews A, Santa-Maria C, Jeter S, Kai C, Semenza G, Stearns V. Abstract P3-07-62: Association of overexpression of hypoxia inducible factor 1α with response to neoadjuvant chemotherapy in early stage breast cancer Cancer Research. 76. DOI: 10.1158/1538-7445.Sabcs15-P3-07-62 |
0.525 |
|
2015 |
Zhang H, Lu H, Xiang L, Bullen JW, Zhang C, Samanta D, Gilkes DM, He J, Semenza GL. HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 26512116 DOI: 10.1073/Pnas.1520032112 |
0.824 |
|
2015 |
Hubbi ME, Semenza GL. Regulation of cell proliferation by hypoxia-inducible factors. American Journal of Physiology. Cell Physiology. 309: C775-82. PMID 26491052 DOI: 10.1152/Ajpcell.00279.2015 |
0.783 |
|
2015 |
Semenza GL. Regulation of the breast cancer stem cell phenotype by hypoxia-inducible factors. Clinical Science (London, England : 1979). 129: 1037-45. PMID 26405042 DOI: 10.1042/CS20150451 |
0.499 |
|
2015 |
Semenza GL. AJP-Cell Theme: Cellular Responses to Hypoxia. American Journal of Physiology. Cell Physiology. 309: C349. PMID 26374688 DOI: 10.1152/Ajpcell.Zh0-7805-Editorial.2015 |
0.455 |
|
2015 |
Prabhakar NR, Semenza GL. Oxygen Sensing and Homeostasis. Physiology (Bethesda, Md.). 30: 340-8. PMID 26328879 DOI: 10.1152/Physiol.00022.2015 |
0.441 |
|
2015 |
Ganten D, Semenza G, Sommer T. 151 years Berliner Klinische Wochenschrift and the 20th anniversary of the Journal of Molecular Medicine. Journal of Molecular Medicine (Berlin, Germany). 93: 935-6. PMID 26260526 DOI: 10.1007/S00109-015-1324-9 |
0.307 |
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2015 |
Lu H, Samanta D, Xiang L, Zhang H, Hu H, Chen I, Bullen JW, Semenza GL. Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype. Proceedings of the National Academy of Sciences of the United States of America. 112: E4600-9. PMID 26229077 DOI: 10.1073/Pnas.1513433112 |
0.584 |
|
2015 |
Ma T, Patel H, Babapoor-Farrokhran S, Franklin R, Semenza GL, Sodhi A, Montaner S. KSHV induces aerobic glycolysis and angiogenesis through HIF-1-dependent upregulation of pyruvate kinase 2 in Kaposi's sarcoma. Angiogenesis. PMID 26092770 DOI: 10.1007/S10456-015-9475-4 |
0.514 |
|
2015 |
Xiang L, Gilkes DM, Hu H, Luo W, Bullen JW, Liang H, Semenza GL. HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells. Oncotarget. 6: 11768-78. PMID 26059435 DOI: 10.18632/Oncotarget.4190 |
0.838 |
|
2015 |
Babapoor-Farrokhran S, Jee K, Puchner B, Hassan SJ, Xin X, Rodrigues M, Kashiwabuchi F, Ma T, Hu K, Deshpande M, Daoud Y, Solomon S, Wenick A, Lutty GA, Semenza GL, et al. Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative diabetic retinopathy. Proceedings of the National Academy of Sciences of the United States of America. 112: E3030-9. PMID 26039997 DOI: 10.1073/Pnas.1423765112 |
0.428 |
|
2015 |
Semenza GL, Prabhakar NR. Neural regulation of hypoxia-inducible factors and redox state drives the pathogenesis of hypertension in a rodent model of sleep apnea. Journal of Applied Physiology (Bethesda, Md. : 1985). 119: 1152-6. PMID 25953833 DOI: 10.1152/Japplphysiol.00162.2015 |
0.458 |
|
2015 |
Hubbi ME, Semenza GL. An essential role for chaperone-mediated autophagy in cell cycle progression. Autophagy. 11: 850-1. PMID 25945892 DOI: 10.1080/15548627.2015.1037063 |
0.769 |
|
2015 |
Yuan G, Vasavda C, Peng YJ, Makarenko VV, Raghuraman G, Nanduri J, Gadalla MM, Semenza GL, Kumar GK, Snyder SH, Prabhakar NR. Protein kinase G-regulated production of H2S governs oxygen sensing. Science Signaling. 8: ra37. PMID 25900831 DOI: 10.1126/Scisignal.2005846 |
0.393 |
|
2015 |
Wang J, Fu X, Yang K, Jiang Q, Chen Y, Jia J, Duan X, Wang EW, He J, Ran P, Zhong N, Semenza GL, Lu W. Hypoxia inducible factor-1-dependent up-regulation of BMP4 mediates hypoxia-induced increase of TRPC expression in PASMCs. Cardiovascular Research. 107: 108-18. PMID 25824146 DOI: 10.1093/Cvr/Cvv122 |
0.469 |
|
2015 |
Nanduri J, Vaddi DR, Khan SA, Wang N, Makarenko V, Semenza GL, Prabhakar NR. HIF-1α activation by intermittent hypoxia requires NADPH oxidase stimulation by xanthine oxidase. Plos One. 10: e0119762. PMID 25751622 DOI: 10.1371/Journal.Pone.0119762 |
0.479 |
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2015 |
Liu ZJ, Semenza GL, Zhang HF. Hypoxia-inducible factor 1 and breast cancer metastasis. Journal of Zhejiang University. Science. B. 16: 32-43. PMID 25559953 DOI: 10.1631/Jzus.B1400221 |
0.568 |
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2015 |
Luo W, Semenza GL. Abstract 525: PHD3-mediated prolyl hydroxylation of non-muscle actin impairs polymerization and cell motility Cancer Research. 75: 525-525. DOI: 10.1158/1538-7445.Am2015-525 |
0.679 |
|
2015 |
Lu H, Samanta D, Xiang L, Zhang H, Hu H, Chen I, Bullen JW, Semenza GL. Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype Proceedings of the National Academy of Sciences of the United States of America. 112: E4600-E4609. DOI: 10.1073/pnas.1513433112 |
0.442 |
|
2014 |
Xiang L, Gilkes DM, Hu H, Takano N, Luo W, Lu H, Bullen JW, Samanta D, Liang H, Semenza GL. Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype. Oncotarget. 5: 12509-27. PMID 25587023 DOI: 10.18632/Oncotarget.2997 |
0.856 |
|
2014 |
Samanta D, Gilkes DM, Chaturvedi P, Xiang L, Semenza GL. Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells. Proceedings of the National Academy of Sciences of the United States of America. 111: E5429-38. PMID 25453096 DOI: 10.1073/Pnas.1421438111 |
0.84 |
|
2014 |
Hu H, Takano N, Xiang L, Gilkes DM, Luo W, Semenza GL. Hypoxia-inducible factors enhance glutamate signaling in cancer cells. Oncotarget. 5: 8853-68. PMID 25326682 DOI: 10.18632/Oncotarget.2593 |
0.82 |
|
2014 |
Chapiro J, Sur S, Savic LJ, Ganapathy-Kanniappan S, Reyes J, Duran R, Thiruganasambandam SC, Moats CR, Lin M, Luo W, Tran PT, Herman JM, Semenza GL, Ewald AJ, Vogelstein B, et al. Systemic delivery of microencapsulated 3-bromopyruvate for the therapy of pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 6406-17. PMID 25326230 DOI: 10.1158/1078-0432.Ccr-14-1271 |
0.694 |
|
2014 |
Huang D, Li T, Li X, Zhang L, Sun L, He X, Zhong X, Jia D, Song L, Semenza GL, Gao P, Zhang H. HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression. Cell Reports. 8: 1930-42. PMID 25242319 DOI: 10.1016/J.Celrep.2014.08.028 |
0.539 |
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2014 |
Lorenzo FR, Huff C, Myllymäki M, Olenchock B, Swierczek S, Tashi T, Gordeuk V, Wuren T, Ri-Li G, McClain DA, Khan TM, Koul PA, Guchhait P, Salama ME, Xing J, ... Semenza GL, et al. A genetic mechanism for Tibetan high-altitude adaptation. Nature Genetics. 46: 951-6. PMID 25129147 DOI: 10.1038/Ng.3067 |
0.574 |
|
2014 |
Luo W, Lin B, Wang Y, Zhong J, O'Meally R, Cole RN, Pandey A, Levchenko A, Semenza GL. PHD3-mediated prolyl hydroxylation of nonmuscle actin impairs polymerization and cell motility. Molecular Biology of the Cell. 25: 2788-96. PMID 25079693 DOI: 10.1091/Mbc.E14-02-0775 |
0.67 |
|
2014 |
Hubbi ME, Gilkes DM, Hu H, Kshitiz, Ahmed I, Semenza GL. Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression. Proceedings of the National Academy of Sciences of the United States of America. 111: E3325-34. PMID 25071185 DOI: 10.1073/Pnas.1412840111 |
0.817 |
|
2014 |
Takano N, Sarfraz Y, Gilkes DM, Chaturvedi P, Xiang L, Suematsu M, Zagzag D, Semenza GL. Decreased expression of cystathionine β-synthase promotes glioma tumorigenesis. Molecular Cancer Research : McR. 12: 1398-406. PMID 24994751 DOI: 10.1158/1541-7786.Mcr-14-0184 |
0.814 |
|
2014 |
Peng YJ, Yuan G, Khan S, Nanduri J, Makarenko VV, Reddy VD, Vasavda C, Kumar GK, Semenza GL, Prabhakar NR. Regulation of hypoxia-inducible factor-α isoforms and redox state by carotid body neural activity in rats. The Journal of Physiology. 592: 3841-58. PMID 24973414 DOI: 10.1113/Jphysiol.2014.273789 |
0.481 |
|
2014 |
Wang T, Gilkes DM, Takano N, Xiang L, Luo W, Bishop CJ, Chaturvedi P, Green JJ, Semenza GL. Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis. Proceedings of the National Academy of Sciences of the United States of America. 111: E3234-42. PMID 24938788 DOI: 10.1073/Pnas.1410041111 |
0.838 |
|
2014 |
Jiang X, Sung YK, Tian W, Qian J, Semenza GL, Nicolls MR. Graft microvascular disease in solid organ transplantation. Journal of Molecular Medicine (Berlin, Germany). 92: 797-810. PMID 24880953 DOI: 10.1007/S00109-014-1173-Y |
0.363 |
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2014 |
Yang C, Jiang L, Zhang H, Shimoda LA, DeBerardinis RJ, Semenza GL. Analysis of hypoxia-induced metabolic reprogramming. Methods in Enzymology. 542: 425-55. PMID 24862279 DOI: 10.1016/B978-0-12-416618-9.00022-4 |
0.471 |
|
2014 |
Gilkes DM, Semenza GL, Wirtz D. Hypoxia and the extracellular matrix: drivers of tumour metastasis. Nature Reviews. Cancer. 14: 430-9. PMID 24827502 DOI: 10.1038/Nrc3726 |
0.8 |
|
2014 |
Chaturvedi P, Gilkes DM, Takano N, Semenza GL. Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment. Proceedings of the National Academy of Sciences of the United States of America. 111: E2120-9. PMID 24799675 DOI: 10.1073/Pnas.1406655111 |
0.823 |
|
2014 |
Takano N, Peng YJ, Kumar GK, Luo W, Hu H, Shimoda LA, Suematsu M, Prabhakar NR, Semenza GL. Hypoxia-inducible factors regulate human and rat cystathionine β-synthase gene expression. The Biochemical Journal. 458: 203-11. PMID 24328859 DOI: 10.1042/Bj20131350 |
0.734 |
|
2014 |
Gilkes DM, Xiang L, Lee SJ, Chaturvedi P, Hubbi ME, Wirtz D, Semenza GL. Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 111: E384-93. PMID 24324133 DOI: 10.1073/Pnas.1321510111 |
0.834 |
|
2014 |
Xiang L, Gilkes DM, Chaturvedi P, Luo W, Hu H, Takano N, Liang H, Semenza GL. Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer. Journal of Molecular Medicine (Berlin, Germany). 92: 151-64. PMID 24248265 DOI: 10.1007/S00109-013-1102-5 |
0.845 |
|
2014 |
Jiang X, Malkovskiy AV, Tian W, Sung YK, Sun W, Hsu JL, Manickam S, Wagh D, Joubert LM, Semenza GL, Rajadas J, Nicolls MR. Promotion of airway anastomotic microvascular regeneration and alleviation of airway ischemia by deferoxamine nanoparticles. Biomaterials. 35: 803-13. PMID 24161166 DOI: 10.1016/J.Biomaterials.2013.09.092 |
0.437 |
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2014 |
Semenza GL. Hypoxia-inducible factor 1 and cardiovascular disease. Annual Review of Physiology. 76: 39-56. PMID 23988176 DOI: 10.1146/Annurev-Physiol-021113-170322 |
0.468 |
|
2014 |
Semenza GL. Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology. Annual Review of Pathology. 9: 47-71. PMID 23937437 DOI: 10.1146/annurev-pathol-012513-104720 |
0.381 |
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2013 |
Gilkes DM, Semenza GL. Role of hypoxia-inducible factors in breast cancer metastasis. Future Oncology (London, England). 9: 1623-36. PMID 24156323 DOI: 10.2217/Fon.13.92 |
0.846 |
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2013 |
Iwase T, Fu J, Yoshida T, Muramatsu D, Miki A, Hashida N, Lu L, Oveson B, Lima e Silva R, Seidel C, Yang M, Connelly S, Shen J, Han B, Wu M, ... Semenza GL, et al. Sustained delivery of a HIF-1 antagonist for ocular neovascularization. Journal of Controlled Release : Official Journal of the Controlled Release Society. 172: 625-33. PMID 24126220 DOI: 10.1016/J.Jconrel.2013.10.008 |
0.396 |
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2013 |
Cai Z, Luo W, Zhan H, Semenza GL. Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart. Proceedings of the National Academy of Sciences of the United States of America. 110: 17462-7. PMID 24101519 DOI: 10.1073/Pnas.1317158110 |
0.685 |
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2013 |
Semenza GL. HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations. The Journal of Clinical Investigation. 123: 3664-71. PMID 23999440 DOI: 10.1172/Jci67230 |
0.497 |
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2013 |
Chen Z, Barbi J, Bu S, Yang HY, Li Z, Gao Y, Jinasena D, Fu J, Lin F, Chen C, Zhang J, Yu N, Li X, Shan Z, Nie J, ... ... Semenza GL, et al. The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3. Immunity. 39: 272-85. PMID 23973223 DOI: 10.1016/J.Immuni.2013.08.006 |
0.691 |
|
2013 |
Xin X, Rodrigues M, Umapathi M, Kashiwabuchi F, Ma T, Babapoor-Farrokhran S, Wang S, Hu J, Bhutto I, Welsbie DS, Duh EJ, Handa JT, Eberhart CG, Lutty G, Semenza GL, et al. Hypoxic retinal Muller cells promote vascular permeability by HIF-1-dependent up-regulation of angiopoietin-like 4. Proceedings of the National Academy of Sciences of the United States of America. 110: E3425-34. PMID 23959876 DOI: 10.1073/Pnas.1217091110 |
0.505 |
|
2013 |
Rodrigues M, Xin X, Jee K, Babapoor-Farrokhran S, Kashiwabuchi F, Ma T, Bhutto I, Hassan SJ, Daoud Y, Baranano D, Solomon S, Lutty G, Semenza GL, Montaner S, Sodhi A. VEGF secreted by hypoxic Müller cells induces MMP-2 expression and activity in endothelial cells to promote retinal neovascularization in proliferative diabetic retinopathy. Diabetes. 62: 3863-73. PMID 23884892 DOI: 10.2337/Db13-0014 |
0.443 |
|
2013 |
Jiang X, Hsu JL, Tian W, Yuan K, Olcholski M, Perez Vde J, Semenza GL, Nicolls MR. Tie2-dependent VHL knockdown promotes airway microvascular regeneration and attenuates invasive growth of Aspergillus fumigatus. Journal of Molecular Medicine (Berlin, Germany). 91: 1081-93. PMID 23797537 DOI: 10.1007/S00109-013-1063-8 |
0.491 |
|
2013 |
Du J, Liu L, Lay F, Wang Q, Dou C, Zhang X, Hosseini SM, Simon A, Rees DJ, Ahmed AK, Sebastian R, Sarkar K, Milner S, Marti GP, Semenza GL, et al. Combination of HIF-1α gene transfection and HIF-1-Activated bone marrow-derived angiogenic cell infusion improves burn wound healing in aged mice Gene Therapy. 20: 1070-1076. PMID 23784441 DOI: 10.1038/Gt.2013.32 |
0.467 |
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2013 |
Hubbi ME, Hu H, Kshitiz, Gilkes DM, Semenza GL. Sirtuin-7 inhibits the activity of hypoxia-inducible factors. The Journal of Biological Chemistry. 288: 20768-75. PMID 23750001 DOI: 10.1074/Jbc.M113.476903 |
0.821 |
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2013 |
Bohuslavova R, Skvorova L, Sedmera D, Semenza GL, Pavlinkova G. Increased susceptibility of HIF-1α heterozygous-null mice to cardiovascular malformations associated with maternal diabetes. Journal of Molecular and Cellular Cardiology. 60: 129-41. PMID 23619295 DOI: 10.1016/J.Yjmcc.2013.04.015 |
0.398 |
|
2013 |
Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, ... ... Semenza GL, et al. A physical sciences network characterization of non-tumorigenic and metastatic cells. Scientific Reports. 3: 1449. PMID 23618955 DOI: 10.1038/Srep01449 |
0.58 |
|
2013 |
Yuan G, Peng YJ, Reddy VD, Makarenko VV, Nanduri J, Khan SA, Garcia JA, Kumar GK, Semenza GL, Prabhakar NR. Mutual antagonism between hypoxia-inducible factors 1α and 2α regulates oxygen sensing and cardio-respiratory homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 110: E1788-96. PMID 23610397 DOI: 10.1073/Pnas.1305961110 |
0.488 |
|
2013 |
Gilkes DM, Chaturvedi P, Bajpai S, Wong CC, Wei H, Pitcairn S, Hubbi ME, Wirtz D, Semenza GL. Collagen prolyl hydroxylases are essential for breast cancer metastasis. Cancer Research. 73: 3285-96. PMID 23539444 DOI: 10.1158/0008-5472.Can-12-3963 |
0.834 |
|
2013 |
Semenza GL. Advances in cancer biology and therapy. Journal of Molecular Medicine (Berlin, Germany). 91: 409. PMID 23515622 DOI: 10.1007/S00109-013-1024-2 |
0.508 |
|
2013 |
Hubbi ME, Hu H, Kshitiz, Ahmed I, Levchenko A, Semenza GL. Chaperone-mediated autophagy targets hypoxia-inducible factor-1α (HIF-1α) for lysosomal degradation. The Journal of Biological Chemistry. 288: 10703-14. PMID 23457305 DOI: 10.1074/Jbc.M112.414771 |
0.798 |
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2013 |
Semenza GL. Blood vessels, disease pathogenesis, and novel therapies. Journal of Molecular Medicine (Berlin, Germany). 91: 283. PMID 23430241 DOI: 10.1007/S00109-013-1009-1 |
0.328 |
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2013 |
Gilkes DM, Bajpai S, Chaturvedi P, Wirtz D, Semenza GL. Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts. The Journal of Biological Chemistry. 288: 10819-29. PMID 23423382 DOI: 10.1074/Jbc.M112.442939 |
0.838 |
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2013 |
Pisarcik S, Maylor J, Lu W, Yun X, Undem C, Sylvester JT, Semenza GL, Shimoda LA. Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1. American Journal of Physiology. Lung Cellular and Molecular Physiology. 304: L549-61. PMID 23418090 DOI: 10.1152/Ajplung.00081.2012 |
0.528 |
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2013 |
Hubbi ME, Kshitiz, Gilkes DM, Rey S, Wong CC, Luo W, Kim DH, Dang CV, Levchenko A, Semenza GL. A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication Science Signaling. 6. PMID 23405012 DOI: 10.1126/Scisignal.2003417 |
0.803 |
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2013 |
Gilkes DM, Bajpai S, Wong CC, Chaturvedi P, Hubbi ME, Wirtz D, Semenza GL. Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis. Molecular Cancer Research : McR. 11: 456-66. PMID 23378577 DOI: 10.1158/1541-7786.Mcr-12-0629 |
0.831 |
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2013 |
Drager LF, Yao Q, Hernandez KL, Shin MK, Bevans-Fonti S, Gay J, Sussan TE, Jun JC, Myers AC, Olivecrona G, Schwartz AR, Halberg N, Scherer PE, Semenza GL, Powell DR, et al. Chronic intermittent hypoxia induces atherosclerosis via activation of adipose angiopoietin-like 4. American Journal of Respiratory and Critical Care Medicine. 188: 240-8. PMID 23328524 DOI: 10.1164/Rccm.201209-1688Oc |
0.409 |
|
2013 |
Chaturvedi P, Gilkes DM, Wong CC, Luo W, Zhang H, Wei H, Takano N, Schito L, Levchenko A, Semenza GL. Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. The Journal of Clinical Investigation. 123: 189-205. PMID 23318994 DOI: 10.1172/Jci64993 |
0.845 |
|
2013 |
Semenza GL. Cancer-stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis. Oncogene. 32: 4057-63. PMID 23222717 DOI: 10.1038/Onc.2012.578 |
0.581 |
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2013 |
Bardia A, Santa-Maria CA, Jacobs LK, Cimino-Mathews A, Huang P, Russell S, Camp M, Habibi M, Lange JR, Jeter S, Powers P, Slater S, Gabrielson E, Carducci MA, Semenza G, et al. Digoxin as an inhibitor of global hypoxia inducible factor-1α (HIF1α) expression and downstream targets in breast cancer: Dig-HIF1 pharmacodynamic trial. Journal of Clinical Oncology. 31: TPS1144-TPS1144. DOI: 10.1200/Jco.2013.31.15_Suppl.Tps1144 |
0.526 |
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2013 |
Chaturvedi P, Gilkes DM, Wong CCL, Kshitiz, Luo W, Zhang H, Wei H, Takano N, Schito L, Levchenko A, Semenza GL. Erratum: Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis (Journal of Clinical Investigation (2013) 123: 1 (189-205) DOI: 10.1172/JCI64993) Journal of Clinical Investigation. 123. DOI: 10.1172/Jci69244 |
0.83 |
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2013 |
Gilkes DM, Chaturvedi P, Wong C, Bajpai S, Wei H, Hubbi M, Wirtz D, Semenza G. Abstract A3: Collagen hydroxylases are essential for breast cancer metastasis Cancer Research. 73. DOI: 10.1158/1538-7445.Tim2013-A3 |
0.828 |
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2013 |
Chaturvedi P, Gilkes D, Semenza G. Abstract 505: Hypoxia inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. Cancer Research. 73: 505-505. DOI: 10.1158/1538-7445.Am2013-505 |
0.85 |
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2013 |
Gilkes DM, Chaturvedi P, Bajpai S, Hubbi M, Wirtz D, Semenza G. Abstract 3937: Collagen prolyl hydroxylases are essential for breast cancer metastasis. Cancer Research. 73: 3937-3937. DOI: 10.1158/1538-7445.Am2013-3937 |
0.829 |
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2013 |
Luo W, Chang R, Zhong J, Pandey A, Semenza GL. Abstract 2319: Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression. Cancer Research. 73: 2319-2319. DOI: 10.1158/1538-7445.Am2013-2319 |
0.776 |
|
2013 |
Semenza GL, Hubbi ME, VanHook AM. Science Signaling Podcast: 12 February 2013 Science Signaling. 6: pc5-pc5. DOI: 10.1126/Scisignal.2004007 |
0.788 |
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2012 |
Luo W, Chang R, Zhong J, Pandey A, Semenza GL. Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression. Proceedings of the National Academy of Sciences of the United States of America. 109: E3367-76. PMID 23129632 DOI: 10.1073/Pnas.1217394109 |
0.776 |
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2012 |
Semenza GL, Prabhakar NR. The role of hypoxia-inducible factors in oxygen sensing by the carotid body. Advances in Experimental Medicine and Biology. 758: 1-5. PMID 23080136 DOI: 10.1007/978-94-007-4584-1_1 |
0.503 |
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2012 |
Schito L, Rey S, Tafani M, Zhang H, Wong CCL, Russo A, Russo MA, Semenza GL. Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells Proceedings of the National Academy of Sciences of the United States of America. 109: E2707-E2716. PMID 23012449 DOI: 10.1073/Pnas.1214019109 |
0.846 |
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2012 |
Krishnamachary B, Penet MF, Nimmagadda S, Mironchik Y, Raman V, Solaiyappan M, Semenza GL, Pomper MG, Bhujwalla ZM. Hypoxia regulates CD44 and its variant isoforms through HIF-1α in triple negative breast cancer. Plos One. 7: e44078. PMID 22937154 DOI: 10.1371/Journal.Pone.0044078 |
0.524 |
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2012 |
Semenza GL. Molecular mechanisms mediating metastasis of hypoxic breast cancer cells. Trends in Molecular Medicine. 18: 534-43. PMID 22921864 DOI: 10.1016/J.Molmed.2012.08.001 |
0.603 |
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2012 |
Luo W, Semenza GL. Emerging roles of PKM2 in cell metabolism and cancer progression. Trends in Endocrinology and Metabolism: Tem. 23: 560-6. PMID 22824010 DOI: 10.1016/J.Tem.2012.06.010 |
0.721 |
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2012 |
Prabhakar NR, Semenza GL. Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2. Physiological Reviews. 92: 967-1003. PMID 22811423 DOI: 10.1152/Physrev.00030.2011 |
0.522 |
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2012 |
Sarkar K, Cai Z, Gupta R, Parajuli N, Fox-Talbot K, Darshan MS, Gonzalez FJ, Semenza GL. Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning. Proceedings of the National Academy of Sciences of the United States of America. 109: 10504-9. PMID 22699503 DOI: 10.1073/Pnas.1208314109 |
0.513 |
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2012 |
Kshitiz, Hubbi ME, Ahn EH, Downey J, Afzal J, Kim DH, Rey S, Chang C, Kundu A, Semenza GL, Abraham RM, Levchenko A. Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors. Science Signaling. 5: ra41. PMID 22669846 DOI: 10.1126/Scisignal.2003002 |
0.795 |
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2012 |
Wei H, Bedja D, Koitabashi N, Xing D, Chen J, Fox-Talbot K, Rouf R, Chen S, Steenbergen C, Harmon JW, Dietz HC, Gabrielson KL, Kass DA, Semenza GL. Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-β signaling. Proceedings of the National Academy of Sciences of the United States of America. 109: E841-50. PMID 22403061 DOI: 10.1073/Pnas.1202081109 |
0.461 |
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2012 |
Semenza GL. Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Trends in Pharmacological Sciences. 33: 207-14. PMID 22398146 DOI: 10.1016/J.Tips.2012.01.005 |
0.549 |
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2012 |
Semenza GL, Prabhakar NR. Gas biology: small molecular medicine. Journal of Molecular Medicine (Berlin, Germany). 90: 213-5. PMID 22349395 DOI: 10.1007/S00109-012-0877-0 |
0.465 |
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2012 |
Prabhakar NR, Semenza GL. Gaseous messengers in oxygen sensing. Journal of Molecular Medicine (Berlin, Germany). 90: 265-72. PMID 22349394 DOI: 10.1007/S00109-012-0876-1 |
0.464 |
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2012 |
Semenza GL. Hypoxia-inducible factors in physiology and medicine. Cell. 148: 399-408. PMID 22304911 DOI: 10.1016/J.Cell.2012.01.021 |
0.506 |
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2012 |
Abud EM, Maylor J, Undem C, Punjabi A, Zaiman AL, Myers AC, Sylvester JT, Semenza GL, Shimoda LA. Digoxin inhibits development of hypoxic pulmonary hypertension in mice. Proceedings of the National Academy of Sciences of the United States of America. 109: 1239-44. PMID 22232678 DOI: 10.1073/Pnas.1120385109 |
0.427 |
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2012 |
Nanduri J, Makarenko V, Reddy VD, Yuan G, Pawar A, Wang N, Khan SA, Zhang X, Kinsman B, Peng YJ, Kumar GK, Fox AP, Godley LA, Semenza GL, Prabhakar NR. Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 109: 2515-20. PMID 22232674 DOI: 10.1073/Pnas.1120600109 |
0.425 |
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2012 |
Wong CC, Zhang H, Gilkes DM, Chen J, Wei H, Chaturvedi P, Hubbi ME, Semenza GL. Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis. Journal of Molecular Medicine (Berlin, Germany). 90: 803-15. PMID 22231744 DOI: 10.1007/S00109-011-0855-Y |
0.839 |
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2012 |
Hubbi ME, Gilkes DM, Baek JH, Semenza GL. Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1. The Journal of Biological Chemistry. 287: 6139-49. PMID 22219185 DOI: 10.1074/Jbc.M111.278630 |
0.821 |
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2012 |
Sarkar K, Rey S, Zhang X, Sebastian R, Marti GP, Fox-Talbot K, Cardona AV, Du J, Tan YS, Liu L, Lay F, Gonzalez FJ, Harmon JW, Semenza GL. Tie2-dependent knockout of HIF-1 impairs burn wound vascularization and homing of bone marrow-derived angiogenic cells. Cardiovascular Research. 93: 162-9. PMID 22028336 DOI: 10.1093/Cvr/Cvr282 |
0.755 |
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2012 |
Zhang H, Wong CC, Wei H, Gilkes DM, Korangath P, Chaturvedi P, Schito L, Chen J, Krishnamachary B, Winnard PT, Raman V, Zhen L, Mitzner WA, Sukumar S, Semenza GL. HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs. Oncogene. 31: 1757-70. PMID 21860410 DOI: 10.1038/Onc.2011.365 |
0.833 |
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2012 |
Semenza GL. Transcriptional regulation by hypoxia-inducible factor 1 molecular mechanisms of oxygen homeostasis. Trends in Cardiovascular Medicine. 6: 151-7. PMID 21232289 DOI: 10.1016/1050-1738(96)00039-4 |
0.522 |
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2012 |
V FRL, Huff CD, Myllymäki M, Swierczek S, Salama ME, Semenza G, Gordeuk VR, Jorde L, Koivunen P, Prchal JT. A Novel EGLN1/PHD2 High-Frequency Variant in Tibetans Protects Against Hypoxia-Induced Polycythemia. Blood. 120: 2079-2079. DOI: 10.1182/Blood.V120.21.2079.2079 |
0.48 |
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2012 |
Kshitiz, Hubbi ME, Ahn EH, Downey J, Afzal J, Kim DH, Rey S, Chang C, Kundu A, Semenza GL, Abraham RM, Levchenko A. Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors (Science Signaling (2012) 5) Science Signaling. 5. DOI: 10.1126/Scisignal.5245Er6 |
0.768 |
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2012 |
Semenza GL. Shifting paradigms for ischaemic preconditioning: AUTHOR'S RETROSPECTIVE Cardiovascular Research. 96: 216-219. DOI: 10.1093/Cvr/Cvs197 |
0.394 |
|
2011 |
Suda T, Takubo K, Semenza GL. Metabolic regulation of hematopoietic stem cells in the hypoxic niche. Cell Stem Cell. 9: 298-310. PMID 21982230 DOI: 10.1016/J.Stem.2011.09.010 |
0.392 |
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2011 |
Wong CC, Gilkes DM, Zhang H, Chen J, Wei H, Chaturvedi P, Fraley SI, Wong CM, Khoo US, Ng IO, Wirtz D, Semenza GL. Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. Proceedings of the National Academy of Sciences of the United States of America. 108: 16369-74. PMID 21911388 DOI: 10.1073/Pnas.1113483108 |
0.84 |
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2011 |
Dang EV, Barbi J, Yang HY, Jinasena D, Yu H, Zheng Y, Bordman Z, Fu J, Kim Y, Yen HR, Luo W, Zeller K, Shimoda L, Topalian SL, Semenza GL, et al. Control of TH17/Treg balance by hypoxia-inducible factor 1 Cell. 146: 772-784. PMID 21871655 DOI: 10.1016/J.Cell.2011.07.033 |
0.661 |
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2011 |
Hattori H, Okuda K, Murase T, Shigetsura Y, Narise K, Semenza GL, Nagasawa H. Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis. Bioorganic & Medicinal Chemistry. 19: 5392-401. PMID 21865046 DOI: 10.1016/J.Bmc.2011.07.060 |
0.494 |
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2011 |
Semenza GL. Oxygen sensing, homeostasis, and disease. The New England Journal of Medicine. 365: 537-47. PMID 21830968 DOI: 10.1056/Nejmra1011165 |
0.507 |
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2011 |
Semenza GL. Regulation of metabolism by hypoxia-inducible factor 1. Cold Spring Harbor Symposia On Quantitative Biology. 76: 347-53. PMID 21785006 DOI: 10.1101/Sqb.2011.76.010678 |
0.543 |
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2011 |
Luo W, Semenza GL. Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells. Oncotarget. 2: 551-6. PMID 21709315 DOI: 10.18632/Oncotarget.299 |
0.729 |
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2011 |
Semenza GL. Hypoxia. Cross talk between oxygen sensing and the cell cycle machinery. American Journal of Physiology. Cell Physiology. 301: C550-2. PMID 21677261 DOI: 10.1152/Ajpcell.00176.2011 |
0.512 |
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2011 |
Hubbi ME, Luo W, Baek JH, Semenza GL. MCM proteins are negative regulators of hypoxia-inducible factor 1. Molecular Cell. 42: 700-12. PMID 21658608 DOI: 10.1016/J.Molcel.2011.03.029 |
0.826 |
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2011 |
Luo W, Hu H, Chang R, Zhong J, Knabel M, O'Meally R, Cole RN, Pandey A, Semenza GL. Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell. 145: 732-44. PMID 21620138 DOI: 10.1016/J.Cell.2011.03.054 |
0.75 |
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2011 |
Jiang X, Khan MA, Tian W, Beilke J, Natarajan R, Kosek J, Yoder MC, Semenza GL, Nicolls MR. Adenovirus-mediated HIF-1α gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection. The Journal of Clinical Investigation. 121: 2336-49. PMID 21606594 DOI: 10.1172/Jci46192 |
0.447 |
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2011 |
Zhang X, Sarkar K, Rey S, Sebastian R, Andrikopoulou E, Marti GP, Fox-Talbot K, Semenza GL, Harmon JW. Aging impairs the mobilization and homing of bone marrow-derived angiogenic cells to burn wounds. Journal of Molecular Medicine (Berlin, Germany). 89: 985-95. PMID 21499736 DOI: 10.1007/S00109-011-0754-2 |
0.707 |
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2011 |
Rangasamy T, Semenza GL, Georas SN. What is hypoxia-inducible factor-1 doing in the allergic lung? Allergy. 66: 815-7. PMID 21480925 DOI: 10.1111/j.1398-9995.2011.02593.x |
0.33 |
|
2011 |
Rey S, Luo W, Shimoda LA, Semenza GL. Metabolic reprogramming by HIF-1 promotes the survival of bone marrow-derived angiogenic cells in ischemic tissue Blood. 117: 4988-4998. PMID 21389314 DOI: 10.1182/Blood-2010-11-321190 |
0.809 |
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2011 |
Keswani SC, Bosch-Marcé M, Reed N, Fischer A, Semenza GL, Höke A. Nitric oxide prevents axonal degeneration by inducing HIF-1-dependent expression of erythropoietin. Proceedings of the National Academy of Sciences of the United States of America. 108: 4986-90. PMID 21383158 DOI: 10.1073/Pnas.1019591108 |
0.723 |
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2011 |
Yuan G, Khan SA, Luo W, Nanduri J, Semenza GL, Prabhakar NR. Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia. Journal of Cellular Physiology. 226: 2925-33. PMID 21302291 DOI: 10.1002/Jcp.22640 |
0.733 |
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2011 |
Semenza GL. A return to cancer metabolism. Journal of Molecular Medicine (Berlin, Germany). 89: 203-4. PMID 21301793 DOI: 10.1007/S00109-011-0733-7 |
0.412 |
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2011 |
Peng YJ, Nanduri J, Khan SA, Yuan G, Wang N, Kinsman B, Vaddi DR, Kumar GK, Garcia JA, Semenza GL, Prabhakar NR. Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension. Proceedings of the National Academy of Sciences of the United States of America. 108: 3065-70. PMID 21288809 DOI: 10.1073/Pnas.1100064108 |
0.483 |
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2011 |
Shimoda LA, Semenza GL. HIF and the lung: role of hypoxia-inducible factors in pulmonary development and disease. American Journal of Respiratory and Critical Care Medicine. 183: 152-6. PMID 21242594 DOI: 10.1164/Rccm.201009-1393Pp |
0.475 |
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2011 |
Kannan KB, Colorado I, Reino D, Palange D, Lu Q, Qin X, Abungu B, Watkins A, Caputo FJ, Xu DZ, Semenza GL, Deitch EA, Feinman R. Hypoxia-inducible factor plays a gut-injurious role in intestinal ischemia reperfusion injury. American Journal of Physiology. Gastrointestinal and Liver Physiology. 300: G853-61. PMID 21183660 DOI: 10.1152/Ajpgi.00459.2010 |
0.417 |
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2011 |
Semenza GL. American Journal of Physiology-Cell Physiology theme: hypoxia. American Journal of Physiology. Cell Physiology. 300: C225. PMID 21084643 DOI: 10.1152/Ajpcell.00468.2010 |
0.419 |
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2011 |
Semenza GL. Hypoxia-inducible factor 1: regulator of mitochondrial metabolism and mediator of ischemic preconditioning. Biochimica Et Biophysica Acta. 1813: 1263-8. PMID 20732359 DOI: 10.1016/J.Bbamcr.2010.08.006 |
0.48 |
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2011 |
Korangath PC, Zhang H, Zhang Z, Huso D, Stearns V, Dang C, Semenza G, Sukumar S. Abstract 4088: Targeting glutamine metabolism in breast cancer Cancer Research. 71: 4088-4088. DOI: 10.1158/1538-7445.Am2011-4088 |
0.523 |
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2011 |
Wong CCL, Gilkes D, Zhang H, Chen J, Chaturvedi P, Fraley S, Semenza GL. Abstract 1521: Hypoxia inducible factor is an important regulator of metastatic niche formation Cancer Research. 71: 1521-1521. DOI: 10.1158/1538-7445.Am2011-1521 |
0.851 |
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2011 |
Sebastian R, Rey S, Zhang X, Sarkar K, Liu L, Marti GP, Amin F, Junkai D, Semenza GL, Harmon JW. Burn wound homing of bone marrow-derived angiogenic cells is impaired by conditional knock out of the hypoxia-inducible factor 1beta gene Journal of the American College of Surgeons. 213: S87-S88. DOI: 10.1016/J.Jamcollsurg.2011.06.409 |
0.717 |
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2010 |
Guan Y, Ramasamy Reddy K, Zhu Q, Li Y, Lee K, Weerasinghe P, Prchal J, Semenza GL, Jing N. G-rich Oligonucleotides Inhibit HIF-1α and HIF-2α and Block Tumor Growth. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 188-197. PMID 28178550 DOI: 10.1038/mt.2009.219 |
0.459 |
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2010 |
Semenza GL. Oxygen homeostasis. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 2: 336-61. PMID 20836033 DOI: 10.1002/wsbm.69 |
0.416 |
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2010 |
Feinman R, Deitch EA, Watkins AC, Abungu B, Colorado I, Kannan KB, Sheth SU, Caputo FJ, Lu Q, Ramanathan M, Attan S, Badami CD, Doucet D, Barlos D, Bosch-Marce M, ... Semenza GL, et al. HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury. American Journal of Physiology. Gastrointestinal and Liver Physiology. 299: G833-43. PMID 20689059 DOI: 10.1152/Ajpgi.00065.2010 |
0.718 |
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2010 |
Lee JS, Kim Y, Kim IS, Kim B, Choi HJ, Lee JM, Shin HJ, Kim JH, Kim JY, Seo SB, Lee H, Binda O, Gozani O, Semenza GL, Kim M, et al. Negative regulation of hypoxic responses via induced Reptin methylation. Molecular Cell. 39: 71-85. PMID 20603076 DOI: 10.1016/J.Molcel.2010.06.008 |
0.42 |
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2010 |
Zhang X, Wei X, Liu L, Marti GP, Ghanamah MS, Arshad MJ, Strom L, Spence R, Jeng J, Milner S, Harmon JW, Semenza GL. Association of increasing burn severity in mice with delayed mobilization of circulating angiogenic cells. Archives of Surgery (Chicago, Ill. : 1960). 145: 259-66. PMID 20231626 DOI: 10.1001/Archsurg.2009.285 |
0.369 |
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2010 |
Rey S, Semenza GL. Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling Cardiovascular Research. 86: 236-242. PMID 20164116 DOI: 10.1093/Cvr/Cvq045 |
0.753 |
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2010 |
Zhang X, Liu L, Wei X, Tan YS, Tong L, Chang R, Ghanamah MS, Reinblatt M, Marti GP, Harmon JW, Semenza GL. Impaired angiogenesis and mobilization of circulating angiogenic cells in HIF-1alpha heterozygous-null mice after burn wounding. Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. 18: 193-201. PMID 20163569 DOI: 10.1111/J.1524-475X.2010.00570.X |
0.43 |
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2010 |
Yoon D, Okhotin DV, Kim B, Okhotina Y, Okhotin DJ, Miasnikova GY, Sergueeva AI, Polyakova LA, Maslow A, Lee Y, Semenza GL, Prchal JT, Gordeuk VR. Increased size of solid organs in patients with Chuvash polycythemia and in mice with altered expression of HIF-1alpha and HIF-2alpha. Journal of Molecular Medicine (Berlin, Germany). 88: 523-30. PMID 20140661 DOI: 10.1007/S00109-010-0599-0 |
0.466 |
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2010 |
Le A, Cooper CR, Gouw AM, Dinavahi R, Maitra A, Deck LM, Royer RE, Vander Jagt DL, Semenza GL, Dang CV. Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proceedings of the National Academy of Sciences of the United States of America. 107: 2037-42. PMID 20133848 DOI: 10.1073/Pnas.0914433107 |
0.509 |
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2010 |
Yoshida T, Zhang H, Iwase T, Shen J, Semenza GL, Campochiaro PA. Digoxin inhibits retinal ischemia-induced HIF-1alpha expression and ocular neovascularization. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 1759-67. PMID 20065104 DOI: 10.1096/Fj.09-145664 |
0.484 |
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2010 |
Kojima H, Kobayashi A, Sakurai D, Kanno Y, Hase H, Takahashi R, Totsuka Y, Semenza GL, Sitkovsky MV, Kobata T. Differentiation stage-specific requirement in hypoxia-inducible factor-1alpha-regulated glycolytic pathway during murine B cell development in bone marrow. Journal of Immunology (Baltimore, Md. : 1950). 184: 154-63. PMID 19949104 DOI: 10.4049/Jimmunol.0800167 |
0.477 |
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2010 |
Luo W, Zhong J, Chang R, Hu H, Pandey A, Semenza GL. Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha. The Journal of Biological Chemistry. 285: 3651-63. PMID 19940151 DOI: 10.1074/Jbc.M109.068577 |
0.696 |
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2010 |
Ugocsai P, Hohenstatt A, Paragh G, Liebisch G, Langmann T, Wolf Z, Weiss T, Groitl P, Dobner T, Kasprzak P, Göbölös L, Falkert A, Seelbach-Goebel B, Gellhaus A, Winterhager E, ... ... Semenza GL, et al. HIF-1beta determines ABCA1 expression under hypoxia in human macrophages. The International Journal of Biochemistry & Cell Biology. 42: 241-52. PMID 19828131 DOI: 10.1016/J.Biocel.2009.10.002 |
0.455 |
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2010 |
Guan Y, Reddy KR, Zhu Q, Li Y, Lee K, Weerasinghe P, Prchal J, Semenza GL, Jing N. G-rich oligonucleotides inhibit HIF-1alpha and HIF-2alpha and block tumor growth. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 188-97. PMID 19755960 DOI: 10.1038/Mt.2009.219 |
0.512 |
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2010 |
Semenza GL. Vascular responses to hypoxia and ischemia. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 648-52. PMID 19729615 DOI: 10.1161/Atvbaha.108.181644 |
0.51 |
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2010 |
Semenza GL. HIF-1 inhibitors for cancer therapy: from gene expression to drug discovery. Current Pharmaceutical Design. 15: 3839-43. PMID 19671047 DOI: 10.2174/138161209789649402 |
0.562 |
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2010 |
Le A, Cooper CR, Gouw A, Maitra A, Dinavahi R, Deck L, Royer R, Jagt DV, Semenza G, Dang CV. Abstract 5453: Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression Cancer Research. 70: 5453-5453. DOI: 10.1158/1538-7445.Am10-5453 |
0.509 |
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2010 |
Sarkar K, Fox-Talbot K, Steenbergen C, Bosch-Marcé M, Semenza GL. Adenoviral transfer of HIF-1α enhances vascular responses to critical limb ischemia in diabetic mice (Proceedings of the National Academy Sciences of United States of America (2009) 106, 44 (18769-18774) DOI: 10.1073/pnas. 0910561106) Proceedings of the National Academy of Sciences of the United States of America. 107. DOI: 10.1073/Pnas.0913116107 |
0.706 |
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2010 |
Zhang X, Sarkar K, Andrikopoulou E, Xing D, Liu L, Reinblatt M, Laines RS, Marti GP, Semenza GL, Harmon JW. Delayed wound healing in aged mice is associated with diminished mobilization of circulating angiogenic cells Journal of the American College of Surgeons. 211: S78. DOI: 10.1016/J.Jamcollsurg.2010.06.205 |
0.363 |
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2009 |
Rey S, Lee K, Wang CJ, Gupta K, Chen S, McMillan A, Bhise N, Levchenko A, Semenza GL. Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia. Proceedings of the National Academy of Sciences of the United States of America. 106: 20399-404. PMID 19948968 DOI: 10.1073/Pnas.0911921106 |
0.753 |
|
2009 |
Semenza GL. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene. 29: 625-34. PMID 19946328 DOI: 10.1038/Onc.2009.441 |
0.566 |
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2009 |
Semenza GL. HIF-1: upstream and downstream of cancer metabolism. Current Opinion in Genetics & Development. 20: 51-6. PMID 19942427 DOI: 10.1016/J.Gde.2009.10.009 |
0.506 |
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2009 |
Semenza GL. Regulation of vascularization by hypoxia-inducible factor 1. Annals of the New York Academy of Sciences. 1177: 2-8. PMID 19845601 DOI: 10.1111/J.1749-6632.2009.05032.X |
0.526 |
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2009 |
Sarkar K, Fox-Talbot K, Steenbergen C, Bosch-Marcé M, Semenza GL. Adenoviral transfer of HIF-1alpha enhances vascular responses to critical limb ischemia in diabetic mice. Proceedings of the National Academy of Sciences of the United States of America. 106: 18769-74. PMID 19841279 DOI: 10.1073/Pnas.0910561106 |
0.702 |
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2009 |
Lee K, Zhang H, Qian DZ, Rey S, Liu JO, Semenza GL. Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization. Proceedings of the National Academy of Sciences of the United States of America. 106: 17910-5. PMID 19805192 DOI: 10.1073/Pnas.0909353106 |
0.761 |
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2009 |
Wikenheiser J, Wolfram JA, Gargesha M, Yang K, Karunamuni G, Wilson DL, Semenza GL, Agani F, Fisher SA, Ward N, Watanabe M. Altered hypoxia-inducible factor-1 alpha expression levels correlate with coronary vessel anomalies. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 238: 2688-700. PMID 19777592 DOI: 10.1002/Dvdy.22089 |
0.471 |
|
2009 |
Siddiq A, Aminova LR, Troy CM, Suh K, Messer Z, Semenza GL, Ratan RR. Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 8828-38. PMID 19587290 DOI: 10.1523/Jneurosci.1779-09.2009 |
0.439 |
|
2009 |
Schipani E, Maes C, Carmeliet G, Semenza GL. Regulation of osteogenesis-angiogenesis coupling by HIFs and VEGF. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 24: 1347-53. PMID 19558314 DOI: 10.1359/Jbmr.090602 |
0.427 |
|
2009 |
Xia M, Huang R, Sun Y, Semenza GL, Aldred SF, Witt KL, Inglese J, Tice RR, Austin CP. Identification of chemical compounds that induce HIF-1alpha activity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 112: 153-63. PMID 19502547 DOI: 10.1093/Toxsci/Kfp123 |
0.526 |
|
2009 |
Semenza GL. Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis. Blood. 114: 2015-9. PMID 19494350 DOI: 10.1182/Blood-2009-05-189985 |
0.486 |
|
2009 |
Semenza G. Recent advances in vascular biology and their clinical relevance. Journal of Molecular Medicine (Berlin, Germany). 87: 547-8. PMID 19449144 DOI: 10.1007/S00109-009-0480-1 |
0.353 |
|
2009 |
Kizaka-Kondoh S, Itasaka S, Zeng L, Tanaka S, Zhao T, Takahashi Y, Shibuya K, Hirota K, Semenza GL, Hiraoka M. Selective killing of hypoxia-inducible factor-1-active cells improves survival in a mouse model of invasive and metastatic pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 3433-41. PMID 19417024 DOI: 10.1158/1078-0432.Ccr-08-2267 |
0.558 |
|
2009 |
Roman J, Rangasamy T, Guo J, Sugunan S, Meednu N, Packirisamy G, Shimoda LA, Golding A, Semenza G, Georas SN. T-cell activation under hypoxic conditions enhances IFN-gamma secretion. American Journal of Respiratory Cell and Molecular Biology. 42: 123-8. PMID 19372249 DOI: 10.1165/Rcmb.2008-0139Oc |
0.437 |
|
2009 |
Semenza GL. Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Physiology (Bethesda, Md.). 24: 97-106. PMID 19364912 DOI: 10.1152/Physiol.00045.2008 |
0.53 |
|
2009 |
Lee K, Qian DZ, Rey S, Wei H, Liu JO, Semenza GL. Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells. Proceedings of the National Academy of Sciences of the United States of America. 106: 2353-8. PMID 19168635 DOI: 10.1073/Pnas.0812801106 |
0.77 |
|
2009 |
Guo J, Lu W, Shimoda LA, Semenza GL, Georas SN. Enhanced interferon-gamma gene expression in T Cells and reduced ovalbumin-dependent lung eosinophilia in hypoxia-inducible factor-1-alpha-deficient mice. International Archives of Allergy and Immunology. 149: 98-102. PMID 19127065 DOI: 10.1159/000189191 |
0.5 |
|
2009 |
Semenza GL. Does loss of CD151 expression promote the metastasis of hypoxic colon cancer cells? Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 7969-70. PMID 19088010 DOI: 10.1158/1078-0432.Ccr-08-2417 |
0.549 |
|
2009 |
Ganten D, Semenza GL, Nolte C. Fostering trust-- Mol Med's scientific integrity policy. Journal of Molecular Medicine (Berlin, Germany). 87: 1-2. PMID 19066832 DOI: 10.1007/S00109-008-0428-X |
0.323 |
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2009 |
Yoon D, Okhotin D, Kim B, Okhotina Y, Okhotin DJ, Miasnikova GY, Sergueeva AI, Polyakova LA, Maslow A, Lee Y, Semenza GL, Prchal JT, Gordeuk VR. Increased Ratios of Internal Organ Volume to Body Mass in Chuvash Polycythemia and HIF-2α Repression of p21Cip Expression through C-MYC. Blood. 114: 5039-5039. DOI: 10.1182/Blood.V114.22.5039.5039 |
0.458 |
|
2009 |
Zhang H, Semenza GL. Reply to Lopez-Lazaro: Evidence that digoxin inhibits human cancer Proceedings of the National Academy of Sciences. 106: E27-E27. DOI: 10.1073/Pnas.0900125106 |
0.446 |
|
2009 |
Semenza G. 5 Hypoxia-inducible factor 1 in cancer pathogenesis and therapy European Journal of Cancer Supplements. 7: 4. DOI: 10.1016/S1359-6349(09)70012-6 |
0.422 |
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2009 |
Xing D, Marti G, Liu L, Zhang X, Reinblatt M, Semenza GL, Harmon JW. Hypoxia colocalizes with increased levels of HIF-1 alpha and its angiogenic transcription products SDF-1 and VEGF in the burn wound Journal of the American College of Surgeons. 209: S74. DOI: 10.1016/J.Jamcollsurg.2009.06.179 |
0.458 |
|
2008 |
Semenza GL. Regulation of cancer cell metabolism by hypoxia-inducible factor 1. Seminars in Cancer Biology. 19: 12-6. PMID 19114105 DOI: 10.1016/J.Semcancer.2008.11.009 |
0.511 |
|
2008 |
Ratan RR, Siddiq A, Aminova L, Langley B, McConoughey S, Karpisheva K, Lee HH, Carmichael T, Kornblum H, Coppola G, Geschwind DH, Hoke A, Smirnova N, Rink C, Roy S, ... ... Semenza GL, et al. Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury. Annals of the New York Academy of Sciences. 1147: 383-94. PMID 19076458 DOI: 10.1196/Annals.1427.033 |
0.454 |
|
2008 |
Semenza GL. Tumor metabolism: cancer cells give and take lactate. The Journal of Clinical Investigation. 118: 3835-7. PMID 19033652 DOI: 10.1172/Jci37373 |
0.496 |
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2008 |
Zhang H, Qian DZ, Tan YS, Lee K, Gao P, Ren YR, Rey S, Hammers H, Chang D, Pili R, Dang CV, Liu JO, Semenza GL. Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth Proceedings of the National Academy of Sciences of the United States of America. 105: 19579-19586. PMID 19020076 DOI: 10.1073/Pnas.0809763105 |
0.762 |
|
2008 |
Nanduri J, Yuan G, Kumar GK, Semenza GL, Prabhakar NR. Transcriptional responses to intermittent hypoxia. Respiratory Physiology & Neurobiology. 164: 277-81. PMID 18692603 DOI: 10.1016/J.Resp.2008.07.006 |
0.501 |
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2008 |
Yuan G, Nanduri J, Khan S, Semenza GL, Prabhakar NR. Induction of HIF-1alpha expression by intermittent hypoxia: involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR. Journal of Cellular Physiology. 217: 674-85. PMID 18651560 DOI: 10.1002/Jcp.21537 |
0.473 |
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2008 |
Sullivan R, Paré GC, Frederiksen LJ, Semenza GL, Graham CH. Hypoxia-induced resistance to anticancer drugs is associated with decreased senescence and requires hypoxia-inducible factor-1 activity. Molecular Cancer Therapeutics. 7: 1961-73. PMID 18645006 DOI: 10.1158/1535-7163.Mct-08-0198 |
0.49 |
|
2008 |
Zhang H, Semenza GL. The expanding universe of hypoxia. Journal of Molecular Medicine (Berlin, Germany). 86: 739-46. PMID 18551266 DOI: 10.1007/S00109-008-0364-9 |
0.453 |
|
2008 |
Semenza GL. Hypoxia-inducible factor 1 and cancer pathogenesis. Iubmb Life. 60: 591-7. PMID 18506846 DOI: 10.1002/Iub.93 |
0.556 |
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2008 |
Liu L, Marti GP, Wei X, Zhang X, Zhang H, Liu YV, Nastai M, Semenza GL, Harmon JW. Age-dependent impairment of HIF-1alpha expression in diabetic mice: Correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells. Journal of Cellular Physiology. 217: 319-27. PMID 18506785 DOI: 10.1002/Jcp.21503 |
0.456 |
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2008 |
Oda S, Oda T, Nishi K, Takabuchi S, Wakamatsu T, Tanaka T, Adachi T, Fukuda K, Semenza GL, Hirota K. Macrophage migration inhibitory factor activates hypoxia-inducible factor in a p53-dependent manner. Plos One. 3: e2215. PMID 18493321 DOI: 10.1371/Journal.Pone.0002215 |
0.567 |
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2008 |
Semenza GL. A new weapon for attacking tumor blood vessels. The New England Journal of Medicine. 358: 2066-7. PMID 18463385 DOI: 10.1056/Nejmcibr0800272 |
0.416 |
|
2008 |
Semenza GL. O2 sensing: only skin deep? Cell. 133: 206-8. PMID 18423190 DOI: 10.1016/J.Cell.2008.04.004 |
0.407 |
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2008 |
Semenza GL. Mitochondrial autophagy: life and breath of the cell. Autophagy. 4: 534-6. PMID 18376135 DOI: 10.4161/Auto.5956 |
0.461 |
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2008 |
Zhang H, Bosch-Marce M, Shimoda LA, Tan YS, Baek JH, Wesley JB, Gonzalez FJ, Semenza GL. Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. The Journal of Biological Chemistry. 283: 10892-903. PMID 18281291 DOI: 10.1074/Jbc.M800102200 |
0.732 |
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2008 |
Nishi K, Oda T, Takabuchi S, Oda S, Fukuda K, Adachi T, Semenza GL, Shingu K, Hirota K. LPS induces hypoxia-inducible factor 1 activation in macrophage-differentiated cells in a reactive oxygen species-dependent manner. Antioxidants & Redox Signaling. 10: 983-95. PMID 18199003 DOI: 10.1089/Ars.2007.1825 |
0.526 |
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2008 |
Whitman EM, Pisarcik S, Luke T, Fallon M, Wang J, Sylvester JT, Semenza GL, Shimoda LA. Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K+ channel expression in pulmonary arterial myocytes. American Journal of Physiology. Lung Cellular and Molecular Physiology. 294: L309-18. PMID 18065659 DOI: 10.1152/Ajplung.00091.2007 |
0.419 |
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2008 |
Kimura M, Takabuchi S, Tanaka T, Murata M, Nishi K, Oda S, Oda T, Kanai M, Fukuda K, Kizaka-Kondoh S, Adachi T, Takabayashi A, Semenza GL, Hirota K. n-Propyl gallate activates hypoxia-inducible factor 1 by modulating intracellular oxygen-sensing systems. The Biochemical Journal. 411: 97-105. PMID 18047470 DOI: 10.1042/Bj20070824 |
0.538 |
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2008 |
Cai Z, Zhong H, Bosch-Marce M, Fox-Talbot K, Wang L, Wei C, Trush MA, Semenza GL. Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1 alpha. Cardiovascular Research. 77: 463-70. PMID 18006459 DOI: 10.1093/Cvr/Cvm035 |
0.725 |
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2008 |
Krishnamachary B, Semenza GL. Analysis of hypoxia-inducible factor 1alpha expression and its effects on invasion and metastasis. Methods in Enzymology. 435: 347-54. PMID 17998062 DOI: 10.1016/S0076-6879(07)35017-9 |
0.569 |
|
2008 |
Semenza GL. Vasculogenesis, angiogenesis, and arteriogenesis: mechanisms of blood vessel formation and remodeling. Journal of Cellular Biochemistry. 102: 840-7. PMID 17891779 DOI: 10.1002/JCB.21523 |
0.288 |
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2008 |
Semenza GL. HIF-1 mediates the Warburg effect in clear cell renal carcinoma. Journal of Bioenergetics and Biomembranes. 39: 231-4. PMID 17551816 DOI: 10.1007/S10863-007-9081-2 |
0.525 |
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2008 |
Ratan RR, Semenza G, Ryu H, Zaman K, Aminova L, Lee J, Kung A, Mwidau A. Transcriptional mechanisms of neuroprotection by iron chelators Journal of Neurochemistry. 81: 80-80. DOI: 10.1046/j.1471-4159.81.s1.102.x |
0.246 |
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2008 |
Semenza GL. Regulation of Ischemia-Induced Vascularization by Hypoxia-Inducible Factor 1 Journal of Molecular and Cellular Cardiology. 45: S7. DOI: 10.1016/J.Yjmcc.2008.09.613 |
0.499 |
|
2008 |
Zhang X, Wei X, Liu L, Marti G, Ghanamah M, Strom L, Spence R, Milner S, Semenza GL, Harmon JW. Increasing severity of thermal injury causes delayed mobilization of circulating angiogenic cells (CACs) and impaired perfusion in a murine burn wound model Journal of the American College of Surgeons. 207: S69-S70. DOI: 10.1016/J.Jamcollsurg.2008.06.173 |
0.353 |
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2007 |
Semenza GL. Hypoxia and human disease-and the Journal of Molecular Medicine. Journal of Molecular Medicine (Berlin, Germany). 85: 1293-4. PMID 18026915 DOI: 10.1007/S00109-007-0285-Z |
0.514 |
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2007 |
Liu YV, Hubbi ME, Pan F, McDonald KR, Mansharamani M, Cole RN, Liu JO, Semenza GL. Calcineurin promotes hypoxia-inducible factor 1alpha expression by dephosphorylating RACK1 and blocking RACK1 dimerization. The Journal of Biological Chemistry. 282: 37064-73. PMID 17965024 DOI: 10.1074/Jbc.M705015200 |
0.762 |
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2007 |
Semenza GL. Evaluation of HIF-1 inhibitors as anticancer agents. Drug Discovery Today. 12: 853-9. PMID 17933687 DOI: 10.1016/J.Drudis.2007.08.006 |
0.572 |
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2007 |
Bosch-Marce M, Okuyama H, Wesley JB, Sarkar K, Kimura H, Liu YV, Zhang H, Strazza M, Rey S, Savino L, Zhou YF, McDonald KR, Na Y, Vandiver S, Rabi A, ... ... Semenza GL, et al. Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia. Circulation Research. 101: 1310-8. PMID 17932327 DOI: 10.1161/Circresaha.107.153346 |
0.825 |
|
2007 |
Semenza GL. Hypoxia-inducible factor 1 (HIF-1) pathway. Science's Stke : Signal Transduction Knowledge Environment. 2007: cm8. PMID 17925579 DOI: 10.1126/Stke.4072007Cm8 |
0.497 |
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2007 |
Semenza GL. Life with oxygen. Science (New York, N.Y.). 318: 62-4. PMID 17916722 DOI: 10.1126/Science.1147949 |
0.49 |
|
2007 |
Baek JH, Liu YV, McDonald KR, Wesley JB, Zhang H, Semenza GL. Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha. The Journal of Biological Chemistry. 282: 33358-66. PMID 17875644 DOI: 10.1074/Jbc.M705627200 |
0.466 |
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2007 |
Tan M, Gu Q, He H, Pamarthy D, Semenza GL, Sun Y. SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1 alpha ubiquitination and degradation. Oncogene. 27: 1404-11. PMID 17828303 DOI: 10.1038/Sj.Onc.1210780 |
0.513 |
|
2007 |
Kim JW, Gao P, Liu YC, Semenza GL, Dang CV. Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1 Molecular and Cellular Biology. 27: 7381-7393. PMID 17785433 DOI: 10.1128/Mcb.00440-07 |
0.557 |
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2007 |
Gao P, Zhang H, Dinavahi R, Li F, Xiang Y, Raman V, Bhujwalla ZM, Felsher DW, Cheng L, Pevsner J, Lee LA, Semenza GL, Dang CV. HIF-dependent antitumorigenic effect of antioxidants in vivo. Cancer Cell. 12: 230-8. PMID 17785204 DOI: 10.1016/J.Ccr.2007.08.004 |
0.454 |
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2007 |
Semenza GL. Regulation of tissue perfusion in mammals by hypoxia-inducible factor 1. Experimental Physiology. 92: 988-91. PMID 17720748 DOI: 10.1113/Expphysiol.2006.036343 |
0.529 |
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2007 |
Semenza GL, Prabhakar NR. HIF-1-dependent respiratory, cardiovascular, and redox responses to chronic intermittent hypoxia. Antioxidants & Redox Signaling. 9: 1391-6. PMID 17627473 DOI: 10.1089/Ars.2007.1691 |
0.489 |
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2007 |
Prabhakar NR, Kumar GK, Nanduri J, Semenza GL. ROS signaling in systemic and cellular responses to chronic intermittent hypoxia. Antioxidants & Redox Signaling. 9: 1397-403. PMID 17627465 DOI: 10.1089/Ars.2007.1732 |
0.433 |
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2007 |
Tomita M, Semenza GL, Michiels C, Matsuda T, Uchihara JN, Okudaira T, Tanaka Y, Taira N, Ohshiro K, Mori N. Activation of hypoxia-inducible factor 1 in human T-cell leukaemia virus type 1-infected cell lines and primary adult T-cell leukaemia cells. The Biochemical Journal. 406: 317-23. PMID 17576198 DOI: 10.1042/Bj20070286 |
0.514 |
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2007 |
Baek JH, Liu YV, McDonald KR, Wesley JB, Hubbi ME, Byun H, Semenza GL. Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha. The Journal of Biological Chemistry. 282: 23572-80. PMID 17558023 DOI: 10.1074/Jbc.M703504200 |
0.769 |
|
2007 |
Semenza GL. Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1. The Biochemical Journal. 405: 1-9. PMID 17555402 DOI: 10.1042/Bj20070389 |
0.468 |
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2007 |
Zhang H, Gao P, Fukuda R, Kumar G, Krishnamachary B, Zeller KI, Dang CV, Semenza GL. HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell. 11: 407-20. PMID 17482131 DOI: 10.1016/J.Ccr.2007.04.001 |
0.497 |
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2007 |
Fukuda R, Zhang H, Kim Jw, Shimoda L, Dang CV, Semenza G. HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells Cell. 129: 111-122. PMID 17418790 DOI: 10.1016/J.Cell.2007.01.047 |
0.377 |
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2007 |
Semenza GL. Hypoxia and cancer. Cancer Metastasis Reviews. 26: 223-4. PMID 17404692 DOI: 10.1007/S10555-007-9058-Y |
0.496 |
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2007 |
Liu YV, Semenza GL. RACK1 vs. HSP90: competition for HIF-1 alpha degradation vs. stabilization. Cell Cycle (Georgetown, Tex.). 6: 656-9. PMID 17361105 DOI: 10.4161/cc.6.6.3981 |
0.366 |
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2007 |
Liu YV, Baek JH, Zhang H, Diez R, Cole RN, Semenza GL. RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha. Molecular Cell. 25: 207-17. PMID 17244529 DOI: 10.1016/J.Molcel.2007.01.001 |
0.452 |
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2007 |
Komatsu DE, Bosch-Marce M, Semenza GL, Hadjiargyrou M. Enhanced bone regeneration associated with decreased apoptosis in mice with partial HIF-1alpha deficiency. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 22: 366-74. PMID 17181398 DOI: 10.1359/Jbmr.061207 |
0.733 |
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2007 |
Xu B, Doughman Y, Turakhia M, Jiang W, Landsettle CE, Agani FH, Semenza GL, Watanabe M, Yang YC. Partial rescue of defects in Cited2-deficient embryos by HIF-1alpha heterozygosity. Developmental Biology. 301: 130-40. PMID 17022961 DOI: 10.1016/J.Ydbio.2006.08.072 |
0.485 |
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2007 |
Liu L, Zhang X, Marti G, Mohebi P, Brown S, Zhang H, Savino L, Miyashita T, Semenza G, Harmon J. Hypoxia-inducible factor-1 alpha deficiency correlates with impaired dermal wound healing in older diabetic mice Journal of the American College of Surgeons. 205: S41-S42. DOI: 10.1016/J.Jamcollsurg.2007.06.096 |
0.414 |
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2007 |
Semenza GL. Biographical sketch—Gregg L. Semenza Cancer and Metastasis Reviews. 26: 221-221. DOI: 10.1007/S10555-007-9057-Z |
0.288 |
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2006 |
Tatum JL, Kelloff GJ, Gillies RJ, Arbeit JM, Brown JM, Chao KS, Chapman JD, Eckelman WC, Fyles AW, Giaccia AJ, Hill RP, Koch CJ, Krishna MC, Krohn KA, Lewis JS, ... ... Semenza GL, et al. Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy. International Journal of Radiation Biology. 82: 699-757. PMID 17118889 DOI: 10.1080/09553000601002324 |
0.578 |
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2006 |
Zhou YF, Bosch-Marce M, Okuyama H, Krishnamachary B, Kimura H, Zhang L, Huso DL, Semenza GL. Spontaneous transformation of cultured mouse bone marrow-derived stromal cells. Cancer Research. 66: 10849-54. PMID 17108121 DOI: 10.1158/0008-5472.Can-06-2146 |
0.714 |
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2006 |
Cai Z, Semenza GL. Is 15-min ischemia too lethal to be an ischemic preconditioning stimulus? Circulation Research. 99: e86. PMID 17095727 DOI: 10.1161/01.Res.0000249066.23049.70 |
0.342 |
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2006 |
Semenza GL. Baffled by bafilomycin: an anticancer agent that induces hypoxia-inducible factor-1alpha expression. Molecular Pharmacology. 70: 1841-3. PMID 17000862 DOI: 10.1124/Mol.106.031062 |
0.513 |
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2006 |
Peng YJ, Yuan G, Ramakrishnan D, Sharma SD, Bosch-Marce M, Kumar GK, Semenza GL, Prabhakar NR. Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia. The Journal of Physiology. 577: 705-16. PMID 16973705 DOI: 10.1113/Jphysiol.2006.114033 |
0.742 |
|
2006 |
Semenza GL. Hypoxia pathway linked to kidney failure. Nature Medicine. 12: 996-7. PMID 16960569 DOI: 10.1038/Nm0906-996 |
0.488 |
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2006 |
Yoon D, Pastore YD, Divoky V, Liu E, Mlodnicka AE, Rainey K, Ponka P, Semenza GL, Schumacher A, Prchal JT. Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development. The Journal of Biological Chemistry. 281: 25703-11. PMID 16787915 DOI: 10.1074/Jbc.M602329200 |
0.467 |
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2006 |
Shimoda LA, Fallon M, Pisarcik S, Wang J, Semenza GL. HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes. American Journal of Physiology. Lung Cellular and Molecular Physiology. 291: L941-9. PMID 16766575 DOI: 10.1152/Ajplung.00528.2005 |
0.471 |
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2006 |
Semenza GL. Regulation of physiological responses to continuous and intermittent hypoxia by hypoxia-inducible factor 1. Experimental Physiology. 91: 803-6. PMID 16740642 DOI: 10.1113/Expphysiol.2006.033498 |
0.522 |
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2006 |
Hirota K, Semenza GL. Regulation of angiogenesis by hypoxia-inducible factor 1. Critical Reviews in Oncology/Hematology. 59: 15-26. PMID 16716598 DOI: 10.1016/J.Critrevonc.2005.12.003 |
0.557 |
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2006 |
Semenza GL. VHL and p53: tumor suppressors team up to prevent cancer. Molecular Cell. 22: 437-9. PMID 16713574 DOI: 10.1016/J.Molcel.2006.05.001 |
0.44 |
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2006 |
Wang J, Weigand L, Lu W, Sylvester JT, Semenza GL, Shimoda LA. Hypoxia inducible factor 1 mediates hypoxia-induced TRPC expression and elevated intracellular Ca2+ in pulmonary arterial smooth muscle cells. Circulation Research. 98: 1528-37. PMID 16709899 DOI: 10.1161/01.Res.0000227551.68124.98 |
0.416 |
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2006 |
Semenza GL. Therapeutic angiogenesis: another passing phase? Circulation Research. 98: 1115-6. PMID 16690890 DOI: 10.1161/01.Res.0000223485.43020.9E |
0.446 |
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2006 |
Semenza GL, Shimoda LA, Prabhakar NR. Regulation of gene expression by HIF-1. Novartis Foundation Symposium. 272: 2-8; discussion 8-14. PMID 16686426 DOI: 10.1002/9780470035009.Ch2 |
0.521 |
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2006 |
Melillo G, Semenza GL. Meeting report: exploiting the tumor microenvironment for therapeutics. Cancer Research. 66: 4558-60. PMID 16651404 DOI: 10.1158/0008-5472.Can-06-0069 |
0.48 |
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2006 |
Okuyama H, Krishnamachary B, Zhou YF, Nagasawa H, Bosch-Marce M, Semenza GL. Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1. The Journal of Biological Chemistry. 281: 15554-63. PMID 16574650 DOI: 10.1074/Jbc.M602003200 |
0.759 |
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2006 |
Semenza GL. Development of novel therapeutic strategies that target HIF-1. Expert Opinion On Therapeutic Targets. 10: 267-80. PMID 16548775 DOI: 10.1517/14728222.10.2.267 |
0.559 |
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2006 |
Kim JW, Tchernyshyov I, Semenza GL, Dang CV. HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia Cell Metabolism. 3: 177-185. PMID 16517405 DOI: 10.1016/J.Cmet.2006.02.002 |
0.472 |
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2006 |
Krishnamachary B, Zagzag D, Nagasawa H, Rainey K, Okuyama H, Baek JH, Semenza GL. Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B. Cancer Research. 66: 2725-31. PMID 16510593 DOI: 10.1158/0008-5472.Can-05-3719 |
0.501 |
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2006 |
Li J, Bosch-Marce M, Nanayakkara A, Savransky V, Fried SK, Semenza GL, Polotsky VY. Altered metabolic responses to intermittent hypoxia in mice with partial deficiency of hypoxia-inducible factor-1alpha. Physiological Genomics. 25: 450-7. PMID 16507783 DOI: 10.1152/Physiolgenomics.00293.2005 |
0.72 |
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2006 |
Oda T, Hirota K, Nishi K, Takabuchi S, Oda S, Yamada H, Arai T, Fukuda K, Kita T, Adachi T, Semenza GL, Nohara R. Activation of hypoxia-inducible factor 1 during macrophage differentiation. American Journal of Physiology. Cell Physiology. 291: C104-13. PMID 16481368 DOI: 10.1152/Ajpcell.00614.2005 |
0.474 |
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2006 |
Campochiaro PA, Alani R, Alitalo K, Brooks P, Caldwell R, Carmeliet P, Claudio PP, D'Amato R, Das A, De Martin R, Detmar M, Ferrara N, Frank RN, Fruttiger M, Giordano A, ... ... Semenza G, et al. Ocular versus extraocular neovascularization: Mirror images or vague resemblances Investigative Ophthalmology and Visual Science. 47: 462-474. PMID 16431938 DOI: 10.1167/Iovs.05-1494 |
0.297 |
|
2006 |
Semenza GL. Involvement of hypoxia-inducible factor 1 in pulmonary pathophysiology. Chest. 128: 592S-594S. PMID 16373853 DOI: 10.1378/Chest.128.6_Suppl.592S |
0.498 |
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2006 |
Semenza GL. New insights into nNOS regulation of vascular homeostasis. The Journal of Clinical Investigation. 115: 2976-8. PMID 16276412 DOI: 10.1172/Jci26792 |
0.462 |
|
2006 |
Lahiri S, Roy A, Baby SM, Hoshi T, Semenza GL, Prabhakar NR. Oxygen sensing in the body. Progress in Biophysics and Molecular Biology. 91: 249-86. PMID 16137743 DOI: 10.1016/J.Pbiomolbio.2005.07.001 |
0.447 |
|
2006 |
Semenza GL. EC does it with HIF Blood. 107: 419-420. DOI: 10.1182/Blood-2005-10-4263 |
0.49 |
|
2006 |
Watkins A, Abungu B, Sentil M, Lu Q, Barlos D, Prescott L, Caputo F, McCracken B, Xu D, Bosch-Marce M, Semenza G, Deitch E, Feinman R. PARTIAL HIF-1?? DEFICIENCY ATTENUATES ISCHEMIA REPERFUSION-MEDIATED GUT AND LUNG INJURY Shock. 25: 5-6. DOI: 10.1097/00024382-200606001-00016 |
0.67 |
|
2006 |
Zhou Y, Su Q, Kimura H, Okuyama H, Bosch-Marce M, Johns RA, Semenza GL. Increased expression of fractalkine and its receptor in mouse hind limb ischemic tissues and bone marrow-derives stem cells under hypoxic condition Vascular Pharmacology. 45: e26. DOI: 10.1016/J.Vph.2006.08.113 |
0.708 |
|
2005 |
Cai Z, Semenza GL. PTEN activity is modulated during ischemia and reperfusion: involvement in the induction and decay of preconditioning. Circulation Research. 97: 1351-9. PMID 16284183 DOI: 10.1161/01.Res.0000195656.52760.30 |
0.342 |
|
2005 |
Hirota K, Semenza GL. Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases. Biochemical and Biophysical Research Communications. 338: 610-6. PMID 16154531 DOI: 10.1016/J.Bbrc.2005.08.193 |
0.502 |
|
2005 |
Semenza GL. Pulmonary vascular responses to chronic hypoxia mediated by hypoxia-inducible factor 1. Proceedings of the American Thoracic Society. 2: 68-70. PMID 16113471 DOI: 10.1513/pats.200404-029MS |
0.426 |
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2005 |
Resar JR, Roguin A, Voner J, Nasir K, Hennebry TA, Miller JM, Ingersoll R, Kasch LM, Semenza GL. Hypoxia-inducible factor 1alpha polymorphism and coronary collaterals in patients with ischemic heart disease. Chest. 128: 787-91. PMID 16100168 DOI: 10.1378/Chest.128.2.787 |
0.441 |
|
2005 |
Maloyan A, Eli-Berchoer L, Semenza GL, Gerstenblith G, Stern MD, Horowitz M. HIF-1alpha-targeted pathways are activated by heat acclimation and contribute to acclimation-ischemic cross-tolerance in the heart. Physiological Genomics. 23: 79-88. PMID 16046617 DOI: 10.1152/Physiolgenomics.00279.2004 |
0.454 |
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2005 |
Zagzag D, Krishnamachary B, Yee H, Okuyama H, Chiriboga L, Ali MA, Melamed J, Semenza GL. Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor. Cancer Research. 65: 6178-88. PMID 16024619 DOI: 10.1158/0008-5472.Can-04-4406 |
0.482 |
|
2005 |
Xu Q, Briggs J, Park S, Niu G, Kortylewski M, Zhang S, Gritsko T, Turkson J, Kay H, Semenza GL, Cheng JQ, Jove R, Yu H. Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways Oncogene. 24: 5552-5560. PMID 16007214 DOI: 10.1038/Sj.Onc.1208719 |
0.516 |
|
2005 |
Patel TH, Kimura H, Weiss CR, Semenza GL, Hofmann LV. Constitutively active HIF-1alpha improves perfusion and arterial remodeling in an endovascular model of limb ischemia. Cardiovascular Research. 68: 144-54. PMID 15921668 DOI: 10.1016/J.Cardiores.2005.05.002 |
0.417 |
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2005 |
Greijer AE, van der Groep P, Kemming D, Shvarts A, Semenza GL, Meijer GA, van de Wiel MA, Belien JA, van Diest PJ, van der Wall E. Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1). The Journal of Pathology. 206: 291-304. PMID 15906272 DOI: 10.1002/Path.1778 |
0.52 |
|
2005 |
Gray MJ, Zhang J, Ellis LM, Semenza GL, Evans DB, Watowich SS, Gallick GE. HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas. Oncogene. 24: 3110-20. PMID 15735682 DOI: 10.1038/Sj.Onc.1208513 |
0.537 |
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2005 |
Baek JH, Mahon PC, Oh J, Kelly B, Krishnamachary B, Pearson M, Chan DA, Giaccia AJ, Semenza GL. OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha. Molecular Cell. 17: 503-12. PMID 15721254 DOI: 10.1016/J.Molcel.2005.01.011 |
0.489 |
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2005 |
Yuan G, Nanduri J, Bhasker CR, Semenza GL, Prabhakar NR. Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia. The Journal of Biological Chemistry. 280: 4321-8. PMID 15569687 DOI: 10.1074/Jbc.M407706200 |
0.501 |
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2005 |
Manalo DJ, Rowan A, Lavoie T, Natarajan L, Kelly BD, Ye SQ, Garcia JG, Semenza GL. Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1. Blood. 105: 659-69. PMID 15374877 DOI: 10.1182/Blood-2004-07-2958 |
0.548 |
|
2005 |
Dang CV, Semenza GL. Cancer energy metabolism Drug Discovery Today: Disease Mechanisms. 2. DOI: 10.1016/J.Ddmec.2005.05.039 |
0.39 |
|
2004 |
Takabuchi S, Hirota K, Nishi K, Oda S, Oda T, Shingu K, Takabayashi A, Adachi T, Semenza GL, Fukuda K. The intravenous anesthetic propofol inhibits hypoxia-inducible factor 1 activity in an oxygen tension-dependent manner. Febs Letters. 577: 434-8. PMID 15556623 DOI: 10.1016/J.Febslet.2004.10.042 |
0.54 |
|
2004 |
Takabuchi S, Hirota K, Nishi K, Oda S, Oda T, Shingu K, Takabayashi A, Adachi T, Semenza GL, Fukuda K. The inhibitory effect of sodium nitroprusside on HIF-1 activation is not dependent on nitric oxide-soluble guanylyl cyclase pathway. Biochemical and Biophysical Research Communications. 324: 417-23. PMID 15465035 DOI: 10.1016/J.Bbrc.2004.09.064 |
0.518 |
|
2004 |
Semenza GL. Hydroxylation of HIF-1: oxygen sensing at the molecular level. Physiology (Bethesda, Md.). 19: 176-82. PMID 15304631 DOI: 10.1152/Physiol.00001.2004 |
0.474 |
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2004 |
Hirota K, Fukuda R, Takabuchi S, Kizaka-Kondoh S, Adachi T, Fukuda K, Semenza GL. Induction of hypoxia-inducible factor 1 activity by muscarinic acetylcholine receptor signaling. The Journal of Biological Chemistry. 279: 41521-8. PMID 15280370 DOI: 10.1074/Jbc.M405164200 |
0.504 |
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2004 |
Stoeltzing O, McCarty MF, Wey JS, Fan F, Liu W, Belcheva A, Bucana CD, Semenza GL, Ellis LM. Role of hypoxia-inducible factor 1alpha in gastric cancer cell growth, angiogenesis, and vessel maturation. Journal of the National Cancer Institute. 96: 946-56. PMID 15199114 DOI: 10.1093/Jnci/Djh168 |
0.535 |
|
2004 |
Semenza GL. Intratumoral hypoxia, radiation resistance, and HIF-1. Cancer Cell. 5: 405-6. PMID 15144945 DOI: 10.1016/S1535-6108(04)00118-7 |
0.475 |
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2004 |
Kaufman B, Scharf O, Arbeit J, Ashcroft M, Brown JM, Bruick RK, Chapman JD, Evans SM, Giaccia AJ, Harris AL, Huang E, Johnson R, Kaelin W, Koch CJ, Maxwell P, ... ... Semenza GL, et al. Proceedings of the Oxygen Homeostasis/Hypoxia Meeting. Cancer Research. 64: 3350-6. PMID 15126380 DOI: 10.1158/0008-5472.Can-03-2611 |
0.626 |
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2004 |
Cai Z, Semenza GL. Phosphatidylinositol-3-kinase signaling is required for erythropoietin-mediated acute protection against myocardial ischemia/reperfusion injury. Circulation. 109: 2050-3. PMID 15117842 DOI: 10.1161/01.Cir.0000127954.98131.23 |
0.361 |
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2004 |
Zhong H, Semenza GL, Simons JW, De Marzo AM. Up-regulation of hypoxia-inducible factor 1alpha is an early event in prostate carcinogenesis. Cancer Detection and Prevention. 28: 88-93. PMID 15068831 DOI: 10.1016/J.Cdp.2003.12.009 |
0.409 |
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2004 |
Shimoda LA, Semenza GL. Functional analysis of the role of hypoxia-inducible factor 1 in the pathogenesis of hypoxic pulmonary hypertension. Methods in Enzymology. 381: 121-9. PMID 15063669 DOI: 10.1016/S0076-6879(04)81007-3 |
0.498 |
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2004 |
Semenza GL. O2-regulated gene expression: transcriptional control of cardiorespiratory physiology by HIF-1. Journal of Applied Physiology (Bethesda, Md. : 1985). 96: 1173-7; discussion 1. PMID 14766767 DOI: 10.1152/Japplphysiol.00770.2003 |
0.508 |
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2004 |
Kasuno K, Takabuchi S, Fukuda K, Kizaka-Kondoh S, Yodoi J, Adachi T, Semenza GL, Hirota K. Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling. The Journal of Biological Chemistry. 279: 2550-8. PMID 14600153 DOI: 10.1074/jbc.M308197200 |
0.44 |
|
2004 |
Stoeltzing O, McCarty MF, Wey J, Fan F, Liu W, Bucana CD, Mansfield P, Semenza GL, Ellis LM. Inhibition of HIF-1α reduces tumor growth and angiogenesis of human gastric cancer Annals of Surgical Oncology. 11. DOI: 10.1007/Bf02524012 |
0.459 |
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2003 |
Kelly BD, Hackett SF, Hirota K, Oshima Y, Cai Z, Berg-Dixon S, Rowan A, Yan Z, Campochiaro PA, Semenza GL. Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1. Circulation Research. 93: 1074-81. PMID 14576200 DOI: 10.1161/01.Res.0000102937.50486.1B |
0.533 |
|
2003 |
Semenza GL. Targeting HIF-1 for cancer therapy. Nature Reviews. Cancer. 3: 721-32. PMID 13130303 DOI: 10.1038/Nrc1187 |
0.57 |
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2003 |
Stoeltzing O, Liu W, Reinmuth N, Fan F, Parikh AA, Bucana CD, Evans DB, Semenza GL, Ellis LM. Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer. The American Journal of Pathology. 163: 1001-11. PMID 12937141 DOI: 10.1016/S0002-9440(10)63460-8 |
0.501 |
|
2003 |
Cai Z, Manalo DJ, Wei G, Rodriguez ER, Fox-Talbot K, Lu H, Zweier JL, Semenza GL. Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury. Circulation. 108: 79-85. PMID 12796124 DOI: 10.1161/01.Cir.0000078635.89229.8A |
0.432 |
|
2003 |
Fukuda R, Kelly B, Semenza GL. Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1. Cancer Research. 63: 2330-4. PMID 12727858 |
0.464 |
|
2003 |
Bos R, van der Groep P, Greijer AE, Shvarts A, Meijer S, Pinedo HM, Semenza GL, van Diest PJ, van der Wall E. Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma. Cancer. 97: 1573-81. PMID 12627523 DOI: 10.1002/cncr.11246 |
0.468 |
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2003 |
Krishnamachary B, Berg-Dixon S, Kelly B, Agani F, Feldser D, Ferreira G, Iyer N, LaRusch J, Pak B, Taghavi P, Semenza GL. Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. Cancer Research. 63: 1138-43. PMID 12615733 |
0.474 |
|
2003 |
Büchler P, Reber HA, Büchler M, Shrinkante S, Büchler MW, Friess H, Semenza GL, Hines OJ. Hypoxia-inducible factor 1 regulates vascular endothelial growth factor expression in human pancreatic cancer. Pancreas. 26: 56-64. PMID 12499918 DOI: 10.1097/00006676-200301000-00010 |
0.45 |
|
2003 |
Janssen HL, Haustermans KM, Sprong D, Blommestijn G, Hofland I, Hoebers FJ, Blijweert E, Raleigh JA, Semenza GL, Varia MA, Balm AJ, van Velthuysen ML, Delaere P, Sciot R, Begg AC. HIF-1A, pimonidazole, and iododeoxyuridine to estimate hypoxia and perfusion in human head-and-neck tumors. International Journal of Radiation Oncology, Biology, Physics. 54: 1537-49. PMID 12459383 DOI: 10.1016/S0360-3016(02)03935-4 |
0.397 |
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2002 |
Ang SO, Chen H, Hirota K, Gordeuk VR, Jelinek J, Guan Y, Liu E, Sergueeva AI, Miasnikova GY, Mole D, Maxwell PH, Stockton DW, Semenza GL, Prchal JT. Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia Nature Genetics. 32: 614-621. PMID 12415268 DOI: 10.1038/Ng1019 |
0.447 |
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2002 |
Semenza G. Signal transduction to hypoxia-inducible factor 1. Biochemical Pharmacology. 64: 993-8. PMID 12213597 DOI: 10.1016/S0006-2952(02)01168-1 |
0.517 |
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2002 |
Semenza GL. Physiology meets biophysics: visualizing the interaction of hypoxia-inducible factor 1 alpha with p300 and CBP. Proceedings of the National Academy of Sciences of the United States of America. 99: 11570-2. PMID 12186981 DOI: 10.1073/Pnas.192442299 |
0.463 |
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2002 |
Fukuda R, Hirota K, Fan F, Jung YD, Ellis LM, Semenza GL. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. The Journal of Biological Chemistry. 277: 38205-11. PMID 12149254 DOI: 10.1074/Jbc.M203781200 |
0.521 |
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2002 |
Treins C, Giorgetti-Peraldi S, Murdaca J, Semenza GL, Van Obberghen E. Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway. The Journal of Biological Chemistry. 277: 27975-81. PMID 12032158 DOI: 10.1074/Jbc.M204152200 |
0.504 |
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2002 |
Cargile CB, Goh DL, Goodman BK, Chen XN, Korenberg JR, Semenza GL, Thomas GH. Molecular cytogenetic characterization of a subtle interstitial del(3)(p25.3p26.2) in a patient with deletion 3p syndrome. American Journal of Medical Genetics. 109: 133-8. PMID 11977162 DOI: 10.1002/Ajmg.10323 |
0.322 |
|
2002 |
Semenza GL. HIF-1 and tumor progression: pathophysiology and therapeutics. Trends in Molecular Medicine. 8: S62-7. PMID 11927290 DOI: 10.1016/S1471-4914(02)02317-1 |
0.567 |
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2002 |
Semenza GL. Involvement of hypoxia-inducible factor 1 in human cancer. Internal Medicine (Tokyo, Japan). 41: 79-83. PMID 11868612 DOI: 10.2169/Internalmedicine.41.79 |
0.55 |
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2002 |
Kojima H, Gu H, Nomura S, Caldwell CC, Kobata T, Carmeliet P, Semenza GL, Sitkovsky MV. Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice. Proceedings of the National Academy of Sciences of the United States of America. 99: 2170-4. PMID 11854513 DOI: 10.1073/Pnas.052706699 |
0.476 |
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2002 |
Kline DD, Peng YJ, Manalo DJ, Semenza GL, Prabhakar NR. Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha. Proceedings of the National Academy of Sciences of the United States of America. 99: 821-6. PMID 11792862 DOI: 10.1073/Pnas.022634199 |
0.641 |
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2002 |
Bos R, van Der Hoeven JJ, van Der Wall E, van Der Groep P, van Diest PJ, Comans EF, Joshi U, Semenza GL, Hoekstra OS, Lammertsma AA, Molthoff CF. Biologic correlates of (18)fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 20: 379-87. PMID 11786564 |
0.407 |
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2002 |
Itoh T, Namba T, Fukuda K, Semenza GL, Hirota K. Reversible inhibition of hypoxia-inducible factor 1 activation by exposure of hypoxic cells to the volatile anesthetic halothane. Febs Letters. 509: 225-9. PMID 11741593 DOI: 10.1016/S0014-5793(01)03119-2 |
0.552 |
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2001 |
Semenza GL. Angiogenesis in ischemic and neoplastic disorders. Annual Review of Medicine. 54: 17-28. PMID 12359828 DOI: 10.1146/Annurev.Med.54.101601.152418 |
0.499 |
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2001 |
Semenza GL, Artemov D, Bedi A, Bhujwalla Z, Chiles K, Feldser D, Laughner E, Ravi R, Simons J, Taghavi P, Zhong H. 'The metabolism of tumours': 70 years later Novartis Foundation Symposium. 240: 251-260. PMID 11727934 DOI: 10.1002/0470868716.Ch17 |
0.538 |
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2001 |
Tuder RM, Chacon M, Alger L, Wang J, Taraseviciene-Stewart L, Kasahara Y, Cool CD, Bishop AE, Geraci M, Semenza GL, Yacoub M, Polak JM, Voelkel NF. Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis. The Journal of Pathology. 195: 367-74. PMID 11673836 DOI: 10.1002/Path.953 |
0.463 |
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2001 |
Mahon PC, Hirota K, Semenza GL. FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes & Development. 15: 2675-86. PMID 11641274 DOI: 10.1101/Gad.924501 |
0.498 |
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2001 |
Semenza GL. HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Cell. 107: 1-3. PMID 11595178 DOI: 10.1016/S0092-8674(01)00518-9 |
0.491 |
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2001 |
Semenza GL. Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology. Trends in Molecular Medicine. 7: 345-50. PMID 11516994 DOI: 10.1016/S1471-4914(01)02090-1 |
0.545 |
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2001 |
Semenza GL. Regulation of hypoxia-induced angiogenesis: a chaperone escorts VEGF to the dance. The Journal of Clinical Investigation. 108: 39-40. PMID 11435455 DOI: 10.1172/Jci13374 |
0.534 |
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2001 |
Shimoda LA, Manalo DJ, Sham JS, Semenza GL, Sylvester JT. Partial HIF-1alpha deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia. American Journal of Physiology. Lung Cellular and Molecular Physiology. 281: L202-8. PMID 11404263 DOI: 10.1152/Ajplung.2001.281.1.L202 |
0.432 |
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2001 |
Laughner E, Taghavi P, Chiles K, Mahon PC, Semenza GL. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Molecular and Cellular Biology. 21: 3995-4004. PMID 11359907 DOI: 10.1128/Mcb.21.12.3995-4004.2001 |
0.55 |
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2001 |
Semenza GL. Hypoxia-inducible factor 1: control of oxygen homeostasis in health and disease. Pediatric Research. 49: 614-7. PMID 11328942 DOI: 10.1203/00006450-200105000-00002 |
0.561 |
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2001 |
Hirota K, Semenza GL. Rac1 activity is required for the activation of hypoxia-inducible factor 1. The Journal of Biological Chemistry. 276: 21166-72. PMID 11283021 DOI: 10.1074/Jbc.M100677200 |
0.534 |
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2001 |
Dong Z, Venkatachalam MA, Wang J, Patel Y, Saikumar P, Semenza GL, Force T, Nishiyama J. Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia. Hif-1-independent mechanisms. The Journal of Biological Chemistry. 276: 18702-9. PMID 11278985 DOI: 10.1074/Jbc.M011774200 |
0.549 |
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2001 |
Semenza GL. HIF-1 and mechanisms of hypoxia sensing. Current Opinion in Cell Biology. 13: 167-71. PMID 11248550 DOI: 10.1016/S0955-0674(00)00194-0 |
0.506 |
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2001 |
Semenza GL. HIF-1: using two hands to flip the angiogenic switch. Cancer Metastasis Reviews. 19: 59-65. PMID 11191064 DOI: 10.1023/A:1026544214667 |
0.555 |
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2001 |
Bos R, Zhong H, Hanrahan CF, Mommers EC, Semenza GL, Pinedo HM, Abeloff MD, Simons JW, van Diest PJ, van der Wall E. Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis. Journal of the National Cancer Institute. 93: 309-14. PMID 11181778 DOI: 10.1093/Jnci/93.4.309 |
0.554 |
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2001 |
Gardner LB, Li Q, Park MS, Flanagan WM, Semenza GL, Dang CV. Hypoxia Inhibits G1/S Transition through Regulation of p27 Expression Journal of Biological Chemistry. 276: 7919-7926. PMID 11112789 DOI: 10.1074/Jbc.M010189200 |
0.481 |
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2001 |
Maloyan A, Semenza G, Gerstenblith G, Stern M, Horowitz M. Heat-acclimation-ischemia cross-tolerance: Does HIF-1α play a role? Journal of Molecular and Cellular Cardiology. 33: A72. DOI: 10.1016/S0022-2828(01)90285-8 |
0.384 |
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2000 |
Semenza GL. Oxygen-regulated transcription factors and their role in pulmonary disease. Respiratory Research. 1: 159-62. PMID 11667980 DOI: 10.1186/Rr27 |
0.46 |
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2000 |
Zagzag D, Friedlander DR, Margolis B, Grumet M, Semenza GL, Zhong H, Simons JW, Holash J, Wiegand SJ, Yancopoulos GD. Molecular events implicated in brain tumor angiogenesis and invasion. Pediatric Neurosurgery. 33: 49-55. PMID 11025423 DOI: 10.1159/000028975 |
0.465 |
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2000 |
Semenza GL. Surviving ischemia: adaptive responses mediated by hypoxia-inducible factor 1. The Journal of Clinical Investigation. 106: 809-12. PMID 11018065 DOI: 10.1172/Jci11223 |
0.485 |
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2000 |
Bergeron M, Gidday JM, Yu AY, Semenza GL, Ferriero DM, Sharp FR. Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain. Annals of Neurology. 48: 285-96. PMID 10976634 DOI: 10.1002/1531-8249(200009)48:3<285::Aid-Ana2>3.0.Co;2-8 |
0.498 |
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2000 |
Semenza GL. Series Introduction: Tissue ischemia: pathophysiology and therapeutics Journal of Clinical Investigation. 106: 613-614. PMID 10974010 DOI: 10.1172/Jci10913 |
0.435 |
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2000 |
Rivard A, Berthou-Soulie L, Principe N, Kearney M, Curry C, Branellec D, Semenza GL, Isner JM. Age-dependent defect in vascular endothelial growth factor expression is associated with reduced hypoxia-inducible factor 1 activity. The Journal of Biological Chemistry. 275: 29643-7. PMID 10882714 DOI: 10.1074/Jbc.M001029200 |
0.509 |
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2000 |
Zagzag D, Zhong H, Scalzitti JM, Laughner E, Simons JW, Semenza GL. Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression. Cancer. 88: 2606-18. PMID 10861440 DOI: 10.1002/1097-0142(20000601)88:11<2606::AID-CNCR25>3.0.CO;2-W |
0.397 |
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2000 |
Semenza GL. Chairman's summary: mechanisms of oxygen homeostasis, circa 1999. Advances in Experimental Medicine and Biology. 475: 303-10. PMID 10849671 DOI: 10.1007/0-306-46825-5_29 |
0.42 |
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2000 |
Semenza GL, Agani F, Feldser D, Iyer N, Kotch L, Laughner E, Yu A. Hypoxia, HIF-1, and the pathophysiology of common human diseases Advances in Experimental Medicine and Biology. 475: 123-130. PMID 10849654 |
0.427 |
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2000 |
Semenza GL. Hypoxia, clonal selection, and the role of HIF-1 in tumor progression. Critical Reviews in Biochemistry and Molecular Biology. 35: 71-103. PMID 10821478 DOI: 10.1080/10409230091169186 |
0.53 |
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2000 |
Sutter CH, Laughner E, Semenza GL. Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations. Proceedings of the National Academy of Sciences of the United States of America. 97: 4748-53. PMID 10758161 DOI: 10.1073/Pnas.080072497 |
0.499 |
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2000 |
Semenza GL. HIF-1: mediator of physiological and pathophysiological responses to hypoxia. Journal of Applied Physiology (Bethesda, Md. : 1985). 88: 1474-80. PMID 10749844 DOI: 10.1152/Jappl.2000.88.4.1474 |
0.501 |
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2000 |
Becker PM, Alcasabas A, Yu AY, Semenza GL, Bunton TE. Oxygen-independent upregulation of vascular endothelial growth factor and vascular barrier dysfunction during ventilated pulmonary ischemia in isolated ferret lungs. American Journal of Respiratory Cell and Molecular Biology. 22: 272-9. PMID 10696063 DOI: 10.1165/Ajrcmb.22.3.3814 |
0.462 |
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2000 |
Semenza GL. Cellular and molecular dissection of reperfusion injury: ROS within and without. Circulation Research. 86: 117-8. PMID 10666403 DOI: 10.1161/01.Res.86.2.117 |
0.429 |
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2000 |
Semenza GL. Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. Annual Review of Cell and Developmental Biology. 15: 551-78. PMID 10611972 DOI: 10.1146/Annurev.Cellbio.15.1.551 |
0.534 |
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2000 |
Semenza GL. Expression of hypoxia-inducible factor 1: mechanisms and consequences. Biochemical Pharmacology. 59: 47-53. PMID 10605934 DOI: 10.1016/S0006-2952(99)00292-0 |
0.567 |
|
2000 |
Semenza GL. HIF-1 and human disease: one highly involved factor Genes & Development. 14: 1983-1991. DOI: 10.1101/Gad.14.16.1983 |
0.432 |
|
2000 |
Ravi R, Mookerjee B, Bhujwalla ZM, Sutter CH, Artemov D, Zeng Q, Dillehay LE, Madan A, Semenza GL, Bedi A. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α Genes & Development. 14: 34-44. DOI: 10.1101/Gad.14.1.34 |
0.542 |
|
1999 |
Bergeron M, Yu AY, Solway KE, Semenza GL, Sharp FR. Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain. The European Journal of Neuroscience. 11: 4159-70. PMID 10594641 DOI: 10.1046/J.1460-9568.1999.00845.X |
0.508 |
|
1999 |
Zaman K, Ryu H, Hall D, O'Donovan K, Lin KI, Miller MP, Marquis JC, Baraban JM, Semenza GL, Ratan RR. Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1), and erythropoietin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 9821-30. PMID 10559391 DOI: 10.1523/Jneurosci.19-22-09821.1999 |
0.445 |
|
1999 |
Semenza GL. Perspectives on oxygen sensing. Cell. 98: 281-4. PMID 10458603 DOI: 10.1016/S0092-8674(00)81957-1 |
0.433 |
|
1999 |
Yu A, Alcasabas A, Semenza G, Becker P. Differential regulation of vascular endothelial growth factor during ventilated pulmonary ischemia. Chest. 116: 32S. PMID 10424577 DOI: 10.1378/Chest.116.Suppl_1.32S |
0.441 |
|
1999 |
Semenza GL, Agani F, Iyer N, Kotch L, Laughner E, Leung S, Yu A. Regulation of cardiovascular development and physiology by hypoxia-inducible factor 1. Annals of the New York Academy of Sciences. 874: 262-8. PMID 10415537 DOI: 10.1111/J.1749-6632.1999.Tb09241.X |
0.538 |
|
1999 |
Kotch LE, Iyer NV, Laughner E, Semenza GL. Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death. Developmental Biology. 209: 254-67. PMID 10328919 DOI: 10.1006/Dbio.1999.9253 |
0.492 |
|
1999 |
Dang CV, Semenza GL. Oncogenic alterations of metabolism Trends in Biochemical Sciences. 24: 68-72. PMID 10098401 DOI: 10.1016/S0968-0004(98)01344-9 |
0.447 |
|
1999 |
Yu AY, Shimoda LA, Iyer NV, Huso DL, Sun X, McWilliams R, Beaty T, Sham JS, Wiener CM, Sylvester JT, Semenza GL. Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha. The Journal of Clinical Investigation. 103: 691-6. PMID 10074486 DOI: 10.1172/Jci5912 |
0.498 |
|
1999 |
Zaman K, Ryu H, Hall D, O'Donovan K, Lin K, Miller MP, Marquis JC, Baraban JM, Semenza GL, Ratan RR. Protection from Oxidative Stress–Induced Apoptosis in Cortical Neuronal Cultures by Iron Chelators Is Associated with Enhanced DNA Binding of Hypoxia-Inducible Factor-1 and ATF-1/CREB and Increased Expression of Glycolytic Enzymes, p21waf1/cip1, and Erythropoietin The Journal of Neuroscience. 19: 9821-9830. DOI: 10.1523/JNEUROSCI.19-22-09821.1999 |
0.312 |
|
1998 |
Palmer LA, Semenza GL, Stoler MH, Johns RA. Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1. American Journal of Physiology. Lung Cellular and Molecular Physiology. 274: L212-L219. PMID 29585685 DOI: 10.1152/ajplung.1998.274.2.L212 |
0.42 |
|
1998 |
Yu AY, Frid MG, Shimoda LA, Wiener CM, Stenmark K, Semenza GL. Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung. American Journal of Physiology. Lung Cellular and Molecular Physiology. 275: L818-L826. PMID 29585640 DOI: 10.1152/ajplung.1998.275.4.L818 |
0.435 |
|
1998 |
Agani F, Semenza GL. Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia-inducible factor 1 activity. Molecular Pharmacology. 54: 749-54. PMID 9804609 DOI: 10.1124/Mol.54.5.749 |
0.546 |
|
1998 |
Semenza GL. Hypoxia-inducible factor 1: master regulator of O2 homeostasis. Current Opinion in Genetics & Development. 8: 588-94. PMID 9794818 DOI: 10.1016/S0959-437X(98)80016-6 |
0.504 |
|
1998 |
Iyer NV, Leung SW, Semenza GL. The human hypoxia-inducible factor 1α gene: HIF1A structure and evolutionary conservation Genomics. 52: 159-165. PMID 9782081 DOI: 10.1006/Geno.1998.5416 |
0.457 |
|
1998 |
Yu AY, Frid MG, Shimoda LA, Wiener CM, Stenmark K, Semenza GL. Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung. The American Journal of Physiology. 275: L818-26. PMID 9755115 DOI: 10.1152/Ajplung.1998.275.4.L818 |
0.516 |
|
1998 |
Semenza GL, Agani F, Iyer N, Jiang BH, Leung S, Wiener C, Yu A. Hypoxia-inducible factor 1: from molecular biology to cardiopulmonary physiology. Chest. 114: 40S-45S. PMID 9676622 DOI: 10.1378/Chest.114.1_Supplement.40S |
0.467 |
|
1998 |
Liu Y, Christou H, Morita T, Laughner E, Semenza GL, Kourembanas S. Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5' enhancer. The Journal of Biological Chemistry. 273: 15257-62. PMID 9614141 DOI: 10.1074/Jbc.273.24.15257 |
0.506 |
|
1998 |
Martin C, Yu AY, Jiang BH, Davis L, Kimberly D, Hohimer AR, Semenza GL. Cardiac hypertrophy in chronically anemic fetal sheep: Increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1. American Journal of Obstetrics and Gynecology. 178: 527-34. PMID 9539521 DOI: 10.1016/S0002-9378(98)70433-8 |
0.475 |
|
1998 |
Semenza GL. Hypoxia-inducible factor 1 and the molecular physiology of oxygen homeostasis. The Journal of Laboratory and Clinical Medicine. 131: 207-14. PMID 9523843 DOI: 10.1016/S0022-2143(98)90091-9 |
0.467 |
|
1998 |
Palmer LA, Semenza GL, Stoler MH, Johns RA. Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1. The American Journal of Physiology. 274: L212-9. PMID 9486205 DOI: 10.1152/Ajplung.1998.274.2.L212 |
0.403 |
|
1998 |
Iyer NV, Kotch LE, Agani F, Leung SW, Laughner E, Wenger RH, Gassmann M, Gearhart JD, Lawler AM, Yu AY, Semenza GL. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes & Development. 12: 149-62. PMID 9436976 DOI: 10.1101/Gad.12.2.149 |
0.531 |
|
1998 |
Semenza G, Leung S, Agani F, Iyer N, Kotch L, Laughner E, Yu A. Hypoxia-inducible factor 1α: Essential role in cardiovascular development and physiology Pathophysiology. 5: 28. DOI: 10.1016/S0928-4680(98)80385-4 |
0.469 |
|
1998 |
Semenza GL, Agani F, Iyer N, Jiang B, Laughner E, Leung S, Roe R, Wiener C, Yu A. Transcriptional Responses Mediated by Hypoxia-Inducible Factor 1 The Keio Journal of Medicine. 45: 421-427. DOI: 10.1007/978-4-431-68476-3_52 |
0.546 |
|
1997 |
Wang GL, Semenza GL. Molecular basis of hypoxia-induced erythropoietin expression. Current Opinion in Hematology. 3: 156-62. PMID 9372067 DOI: 10.1097/00062752-199603020-00009 |
0.507 |
|
1997 |
Jiang BH, Zheng JZ, Leung SW, Roe R, Semenza GL. Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension. The Journal of Biological Chemistry. 272: 19253-60. PMID 9235919 DOI: 10.1074/Jbc.272.31.19253 |
0.497 |
|
1997 |
Winograd J, Reilly MP, Roe R, Lutz J, Laughner E, Xu X, Hu L, Asakura T, vander Kolk C, Strandberg JD, Semenza GL. Perinatal lethality and multiple craniofacial malformations in MSX2 transgenic mice. Human Molecular Genetics. 6: 369-79. PMID 9147639 DOI: 10.1093/Hmg/6.3.369 |
0.411 |
|
1997 |
Doheny KF, Rasmussen SA, Rutberg J, Semenza GL, Stamberg J, Schwartz M, Batista DA, Stetten G, Thomas GH. Segregation of a familial balanced (12;10) insertion resulting in Dup(10)(q21.2q22.1) and Del(10)(q21.2q22.1) in first cousins. American Journal of Medical Genetics. 69: 188-93. PMID 9056559 DOI: 10.1002/(Sici)1096-8628(19970317)69:2<188::Aid-Ajmg14>3.0.Co;2-H |
0.293 |
|
1997 |
Lee PJ, Jiang BH, Chin BY, Iyer NV, Alam J, Semenza GL, Choi AMK. Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia Journal of Biological Chemistry. 272: 5375-5381. PMID 9038135 DOI: 10.1074/Jbc.272.9.5375 |
0.538 |
|
1997 |
Semenza GL, Agani F, Booth G, Forsythe J, Iyer N, Jiang BH, Leung S, Roe R, Wiener C, Yu A. Structural and functional analysis of hypoxia-inducible factor 1. Kidney International. 51: 553-5. PMID 9027737 DOI: 10.1038/Ki.1997.77 |
0.516 |
|
1997 |
Semenza GL, Jiang BH, Leung SW, Passantino R, Concordet JP, Maire P, Giallongo A. Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. The Journal of Biological Chemistry. 271: 32529-37. PMID 8955077 DOI: 10.1074/Jbc.271.51.32529 |
0.516 |
|
1996 |
Jiang BH, Semenza GL, Bauer C, Marti HH. Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension. The American Journal of Physiology. 271: C1172-80. PMID 8897823 DOI: 10.1152/Ajpcell.1996.271.4.C1172 |
0.477 |
|
1996 |
Semenza GL, Rue EA, Iyer NV, Pang MG, Kearns WG. Assignment of the hypoxia-inducible factor 1alpha gene to a region of conserved synteny on mouse chromosome 12 and human chromosome 14q. Genomics. 34: 437-9. PMID 8786149 DOI: 10.1006/Geno.1996.0311 |
0.384 |
|
1996 |
Forsythe JA, Jiang BH, Iyer NV, Agani F, Leung SW, Koos RD, Semenza GL. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Molecular and Cellular Biology. 16: 4604-13. PMID 8756616 DOI: 10.1128/Mcb.16.9.4604 |
0.55 |
|
1996 |
Wiener CM, Booth G, Semenza GL. In vivo expression of mRNAs encoding hypoxia-inducible factor 1. Biochemical and Biophysical Research Communications. 225: 485-8. PMID 8753788 DOI: 10.1006/Bbrc.1996.1199 |
0.514 |
|
1996 |
Jiang BH, Rue E, Wang GL, Roe R, Semenza GL. Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. The Journal of Biological Chemistry. 271: 17771-8. PMID 8663540 DOI: 10.1074/Jbc.271.30.17771 |
0.474 |
|
1995 |
Wang GL, Semenza GL. Purification and characterization of hypoxia-inducible factor 1. The Journal of Biological Chemistry. 270: 1230-7. PMID 7836384 DOI: 10.1074/Jbc.270.3.1230 |
0.522 |
|
1995 |
Semenza GL, Wang GL, Kundu R. DNA Binding and Transcriptional Properties of Wild-Type and Mutant Forms of the Homeodomain Protein Msx2 Biochemical and Biophysical Research Communications. 209: 257-262. PMID 7726844 DOI: 10.1006/Bbrc.1995.1497 |
0.384 |
|
1995 |
Wang GL, Jiang BH, Semenza GL. Effect of altered redox states on expression and DNA-binding activity of hypoxia-inducible factor 1. Biochemical and Biophysical Research Communications. 212: 550-6. PMID 7626069 DOI: 10.1006/Bbrc.1995.2005 |
0.511 |
|
1995 |
Prchal JT, Semenza GL, Prchal J, Sokol L. Familial polycythemia. Science (New York, N.Y.). 268: 1831-2. PMID 7604250 DOI: 10.1126/science.7604250 |
0.176 |
|
1995 |
Wang GL, Jiang BH, Rue EA, Semenza GL. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proceedings of the National Academy of Sciences of the United States of America. 92: 5510-4. PMID 7539918 DOI: 10.1073/Pnas.92.12.5510 |
0.508 |
|
1995 |
Wang GL, Jiang BH, Semenza GL. Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1. Biochemical and Biophysical Research Communications. 216: 669-75. PMID 7488163 DOI: 10.1006/Bbrc.1995.2674 |
0.494 |
|
1995 |
Sokol L, Luhovy M, Guan Y, Prchal J, Semenza G, Prchal J. Primary familial polycythemia: a frameshift mutation in the erythropoietin receptor gene and increased sensitivity of erythroid progenitors to erythropoietin Blood. 86: 15-22. DOI: 10.1182/blood.V86.1.15.bloodjournal86115 |
0.286 |
|
1994 |
Semenza GL. Erythropoietin gene expression in transgenic mice and human hepatoma cells. Annals of the New York Academy of Sciences. 718: 41-7; discussion 47-. PMID 8185250 DOI: 10.1111/J.1749-6632.1994.Tb55702.X |
0.406 |
|
1994 |
Semenza GL. Transcriptional regulation of gene expression: mechanisms and pathophysiology. Human Mutation. 3: 180-99. PMID 8019554 DOI: 10.1002/Humu.1380030304 |
0.443 |
|
1994 |
Semenza GL. Regulation of Erythropoietin Production: New Insights Into Molecular Mechanisms of Oxygen Homeostasis Hematology/Oncology Clinics of North America. 8: 863-884. DOI: 10.1016/S0889-8588(18)30134-5 |
0.48 |
|
1993 |
Wang GL, Semenza GL. General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proceedings of the National Academy of Sciences of the United States of America. 90: 4304-8. PMID 8387214 DOI: 10.1073/Pnas.90.9.4304 |
0.514 |
|
1993 |
Koury ST, Bondurant MC, Semenza GL, Koury MJ. The use of in situ hybridization to study erythropoietin gene expression in murine kidney and liver Microscopy Research and Technique. 25: 29-39. PMID 8353306 DOI: 10.1002/Jemt.1070250106 |
0.415 |
|
1993 |
Wang G, Semenza G. Desferrioxamine induces erythropoietin gene expression and hypoxia- inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction Blood. 82: 3610-3615. DOI: 10.1182/Blood.V82.12.3610.Bloodjournal82123610 |
0.551 |
|
1992 |
Semenza GL, Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Molecular and Cellular Biology. 12: 5447-54. PMID 1448077 DOI: 10.1128/Mcb.12.12.5447 |
0.498 |
|
1991 |
Semenza GL, Nejfelt MK, Chi SM, Antonarakis SE. Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene. Proceedings of the National Academy of Sciences of the United States of America. 88: 5680-4. PMID 2062846 DOI: 10.1073/Pnas.88.13.5680 |
0.652 |
|
1991 |
Semenza GL, Koury ST, Nejfelt MK, Gearhart JD, Antonarakis SE. Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 88: 8725-9. PMID 1924331 DOI: 10.1073/Pnas.88.19.8725 |
0.651 |
|
1991 |
Koury S, Bondurant M, Koury M, Semenza G. Localization of cells producing erythropoietin in murine liver by in situ hybridization [see comments] Blood. 77: 2497-2503. DOI: 10.1182/Blood.V77.11.2497.Bloodjournal77112497 |
0.389 |
|
1991 |
Koury S, Bondurant M, Koury M, Semenza G. Localization of cells producing erythropoietin in murine liver by in situ hybridization [see comments] Blood. 77: 2497-2503. DOI: 10.1182/blood.v77.11.2497.2497 |
0.288 |
|
1990 |
Semenza GL, Dureza RC, Traystman MD, Gearhart JD, Antonarakis SE. Human erythropoietin gene expression in transgenic mice: multiple transcription initiation sites and cis-acting regulatory elements. Molecular and Cellular Biology. 10: 930-8. PMID 2304468 DOI: 10.1128/mcb.10.3.930-938.1990 |
0.617 |
|
1989 |
Semenza GL, Traystman MD, Gearhart JD, Antonarakis SE. Polycythemia in transgenic mice expressing the human erythropoietin gene. Proceedings of the National Academy of Sciences of the United States of America. 86: 2301-5. PMID 2928334 DOI: 10.1073/Pnas.86.7.2301 |
0.601 |
|
1989 |
Semenza GL, Dowling CE, Kazazian HH. Hinf I polymorphism 3' to the human beta-globin gene detected by the polymerase chain reaction (PCR). Nucleic Acids Research. 17: 2376. PMID 2565032 DOI: 10.1093/Nar/17.6.2376 |
0.612 |
|
1988 |
Semenza GL, Pyeritz RE. Respiratory complications of mucopolysaccharide storage disorders. Medicine. 67: 209-19. PMID 3134589 DOI: 10.1097/00005792-198807000-00002 |
0.343 |
|
1987 |
Semenza GL, Ladias JA, Antonarakis SE. An Xba I polymorphism 3' to the human erythropoietin (EPO) gene. Nucleic Acids Research. 15: 6768. PMID 2888094 DOI: 10.1093/Nar/15.16.6768 |
0.572 |
|
1984 |
Semenza GL, Malladi P, Surrey S, Delgrosso K, Poncz M, Schwartz E. Detection of a novel DNA polymorphism in the beta-globin gene cluster. The Journal of Biological Chemistry. 259: 6045-8. PMID 6327661 |
0.652 |
|
1984 |
Semenza GL, Delgrosso K, Poncz M, Malladi P, Schwartz E, Surrey S. The silent carrier allele: beta thalassemia without a mutation in the beta-globin gene or its immediate flanking regions. Cell. 39: 123-8. PMID 6091904 DOI: 10.1016/0092-8674(84)90197-1 |
0.76 |
|
1984 |
Semenza GL, Delgrosso K, Surrey S, Malladi P, Schwartz E, Ponca M. THE SILENT CARRIER ALLELE: β-THALASSEMIA WITHOUT A MUTATION IN THE β-GLOBIN GENE REGION Pediatric Research. 18: 248A-248A. DOI: 10.1203/00006450-198404001-00931 |
0.779 |
|
1984 |
Semenza GL, Malladi P, Poncz M, Delgrosso K, Schwartz E, Surrey S. DETECTION OF A NOVEL DNA POLYMORPHISM IN THE β-GLOBIN CLUSTER AND EVIDENCE FOR SITE-SPECIFIC RECOMBINATION Pediatric Research. 18: 225A-225A. DOI: 10.1203/00006450-198404001-00794 |
0.765 |
|
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