| Year |
Citation |
Score |
| 2024 |
Fan L, Zhuang Y, Wu H, Li H, Xu Y, Wang Y, He L, Wang S, Chen Z, Cheng J, Xu HE, Wang S. Structural basis of psychedelic LSD recognition at dopamine D receptor. Neuron. PMID 39094559 DOI: 10.1016/j.neuron.2024.07.003 |
0.496 |
|
| 2024 |
Liu H, Guo S, Dai A, Xu P, Li X, Huang S, He X, Wu K, Zhang X, Yang D, Xie X, Xu HE. Author Correction: Structural and functional evidence that GPR30 is not a direct estrogen receptor. Cell Research. PMID 39075201 DOI: 10.1038/s41422-024-00998-1 |
0.695 |
|
| 2024 |
Li C, Xu Y, Su W, He X, Li J, Li X, Xu HE, Yin W. Structural insights into ligand recognition, selectivity, and activation of bombesin receptor subtype-3. Cell Reports. 43: 114511. PMID 39024101 DOI: 10.1016/j.celrep.2024.114511 |
0.45 |
|
| 2024 |
Guo J, Zhou YL, Yang Y, Guo S, You E, Xie X, Jiang Y, Mao C, Xu HE, Zhang Y. Structural basis of tethered agonism and G protein coupling of protease-activated receptors. Cell Research. PMID 38997424 DOI: 10.1038/s41422-024-00997-2 |
0.448 |
|
| 2024 |
Tao L, Wang D, Yuan Q, Zhao F, Zhang Y, Du T, Shen S, Xu HE, Li Y, Yang D, Duan J. Bitter taste receptor TAS2R14 activation and G protein assembly by an intracellular agonist. Cell Research. PMID 38969802 DOI: 10.1038/s41422-024-00995-4 |
0.351 |
|
| 2024 |
Fan W, Xu Y, He X, Luo P, Zhu J, Li J, Wang R, Yuan Q, Wu K, Hu W, Zhao Y, Xu S, Cheng X, Wang Y, Xu HE, et al. Molecular basis for the activation of PAF receptor by PAF. Cell Reports. 43: 114422. PMID 38943642 DOI: 10.1016/j.celrep.2024.114422 |
0.456 |
|
| 2024 |
Shen S, Wang D, Liu H, He X, Cao Y, Chen J, Li S, Cheng X, Xu HE, Duan J. Structural basis for hormone recognition and distinctive Gq protein coupling by the kisspeptin receptor. Cell Reports. 43: 114389. PMID 38935498 DOI: 10.1016/j.celrep.2024.114389 |
0.459 |
|
| 2024 |
Li J, You C, Li Y, Li C, Fan W, Chen Z, Hu W, Wu K, Xu HE, Zhao LH. Structural basis for activation of somatostatin receptor 5 by cyclic neuropeptide agonists. Proceedings of the National Academy of Sciences of the United States of America. 121: e2321710121. PMID 38885377 DOI: 10.1073/pnas.2321710121 |
0.462 |
|
| 2024 |
Li C, Liu H, Li J, He X, Zhu H, Fu W, Xu HE. Molecular basis of ligand recognition and activation of the human succinate receptor SUCR1. Cell Research. PMID 38834763 DOI: 10.1038/s41422-024-00984-7 |
0.303 |
|
| 2024 |
Skiba MA, Sterling SM, Rawson S, Zhang S, Xu H, Jiang H, Nemeth GR, Gilman MSA, Hurley JD, Shen P, Staus DP, Kim J, McMahon C, Lehtinen MK, Rockman HA, et al. Antibodies expand the scope of angiotensin receptor pharmacology. Nature Chemical Biology. PMID 38744986 DOI: 10.1038/s41589-024-01620-6 |
0.37 |
|
| 2024 |
Liu H, Guo S, Dai A, Xu P, Li X, Huang S, He X, Wu K, Zhang X, Yang D, Xie X, Xu HE. Structural and functional evidence that GPR30 is not a direct estrogen receptor. Cell Research. PMID 38744981 DOI: 10.1038/s41422-024-00963-y |
0.701 |
|
| 2024 |
He Q, Yuan Q, Shan H, Wu C, Gu Y, Wu K, Hu W, Zhang Y, He X, Xu HE, Zhao LH. Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors. Cell Discovery. 10: 48. PMID 38710677 DOI: 10.1038/s41421-024-00679-8 |
0.442 |
|
| 2024 |
Shen Q, Tang X, Wen X, Cheng S, Xiao P, Zang SK, Shen DD, Jiang L, Zheng Y, Zhang H, Xu H, Mao C, Zhang M, Hu W, Sun JP, et al. Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). e2310120. PMID 38647423 DOI: 10.1002/advs.202310120 |
0.349 |
|
| 2024 |
Cai H, Guo S, Xu Y, Sun J, Li J, Xia Z, Jiang Y, Xie X, Xu HE. Cryo-EM structures of adenosine receptor AAR bound to selective agonists. Nature Communications. 15: 3252. PMID 38627384 DOI: 10.1038/s41467-024-47207-6 |
0.421 |
|
| 2024 |
Chen Z, Yu J, Wang H, Xu P, Fan L, Sun F, Huang S, Zhang P, Huang H, Gu S, Zhang B, Zhou Y, Wan X, Pei G, Xu HE, et al. Flexible scaffold-based cheminformatics approach for polypharmacological drug design. Cell. PMID 38552625 DOI: 10.1016/j.cell.2024.02.034 |
0.697 |
|
| 2024 |
Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, et al. Structure-based design of non-hypertrophic apelin receptor modulator. Cell. PMID 38428423 DOI: 10.1016/j.cell.2024.02.004 |
0.371 |
|
| 2024 |
Duan J, He XH, Li SJ, Xu HE. Cryo-electron microscopy for GPCR research and drug discovery in endocrinology and metabolism. Nature Reviews. Endocrinology. PMID 38424377 DOI: 10.1038/s41574-024-00957-1 |
0.425 |
|
| 2024 |
Wang JJ, Jin S, Zhang H, Xu Y, Hu W, Jiang Y, Chen C, Wang DW, Xu HE, Wu C. Molecular recognition and activation of the prostacyclin receptor by anti-pulmonary arterial hypertension drugs. Science Advances. 10: eadk5184. PMID 38335293 DOI: 10.1126/sciadv.adk5184 |
0.418 |
|
| 2024 |
Ma D, Hu M, Yang X, Liu Q, Ye F, Cai W, Wang Y, Xu X, Chang S, Wang R, Yang W, Ye S, Su N, Fan M, Xu H, et al. Structural basis for sugar perception by gustatory receptors. Science (New York, N.Y.). eadj2609. PMID 38305684 DOI: 10.1126/science.adj2609 |
0.332 |
|
| 2023 |
Zhu S, Yuan Q, Li X, He X, Shen S, Wang D, Li J, Cheng X, Duan X, Xu HE, Duan J. Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2. Cell Reports. 42: 113406. PMID 37952153 DOI: 10.1016/j.celrep.2023.113406 |
0.394 |
|
| 2023 |
Liu H, Zheng Y, Wang Y, Wang Y, He X, Xu P, Huang S, Yuan Q, Zhang X, Wang L, Jiang K, Chen H, Li Z, Liu W, Wang S, ... Xu HE, et al. Recognition of methamphetamine and other amines by trace amine receptor TAAR1. Nature. PMID 37935377 DOI: 10.1038/s41586-023-06775-1 |
0.736 |
|
| 2023 |
Skiba MA, Sterling SM, Rawson S, Gilman MSA, Xu H, Nemeth GR, Hurley JD, Shen P, Staus DP, Kim J, McMahon C, Lehtinen MK, Wingler LM, Kruse AC. Antibodies Expand the Scope of Angiotensin Receptor Pharmacology. Biorxiv : the Preprint Server For Biology. PMID 37662341 DOI: 10.1101/2023.08.23.554128 |
0.372 |
|
| 2023 |
Duan J, Liu H, Zhao F, Yuan Q, Ji Y, Cai X, He X, Li X, Li J, Wu K, Gao T, Zhu S, Lin S, Wang MW, Cheng X, ... ... Xu HE, et al. GPCR activation and GRK2 assembly by a biased intracellular agonist. Nature. PMID 37532940 DOI: 10.1038/s41586-023-06395-9 |
0.432 |
|
| 2023 |
Zhao LH, He Q, Yuan Q, Gu Y, He X, Shan H, Li J, Wang K, Li Y, Hu W, Wu K, Shen J, Xu HE. Conserved class B GPCR activation by a biased intracellular agonist. Nature. PMID 37524305 DOI: 10.1038/s41586-023-06467-w |
0.415 |
|
| 2023 |
Sun W, Yang F, Zhang H, Yuan Q, Ling S, Wang Y, Lv P, Li Z, Luo Y, Liu D, Yin W, Shi P, Xu HE, Tian C. Structural insights into neurokinin 3 receptor activation by endogenous and analogue peptide agonists. Cell Discovery. 9: 66. PMID 37391393 DOI: 10.1038/s41421-023-00564-w |
0.336 |
|
| 2023 |
Liu H, Zhang Q, He X, Jiang M, Wang S, Yan X, Cheng X, Liu Y, Nan FJ, Xu HE, Xie X, Yin W. Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84. Nature Communications. 14: 3271. PMID 37277332 DOI: 10.1038/s41467-023-38985-6 |
0.375 |
|
| 2023 |
Xu P, Huang S, Krumm BE, Zhuang Y, Mao C, Zhang Y, Wang Y, Huang XP, Liu YF, He X, Li H, Yin W, Jiang Y, Zhang Y, Roth BL, ... Xu HE, et al. Structural genomics of the human dopamine receptor system. Cell Research. PMID 37221270 DOI: 10.1038/s41422-023-00808-0 |
0.729 |
|
| 2023 |
Wang Y, Liu W, Xu Y, He X, Yuan Q, Luo P, Fan W, Zhu J, Zhang X, Cheng X, Jiang Y, Xu HE, Zhuang Y. Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins. Nature Chemical Biology. PMID 37169960 DOI: 10.1038/s41589-023-01339-w |
0.382 |
|
| 2023 |
You C, Zhang Y, Xu Y, Xu P, Li Z, Li H, Huang S, Chen Z, Li J, Xu HE, Jiang Y. Structural basis for motilin and erythromycin recognition by motilin receptor. Science Advances. 9: eade9020. PMID 36921049 DOI: 10.1126/sciadv.ade9020 |
0.738 |
|
| 2023 |
Mao C, Xiao P, Tao XN, Qin J, He QT, Zhang C, Guo SC, Du YQ, Chen LN, Shen DD, Yang ZS, Zhang HQ, Huang SM, He YH, Cheng J, ... ... Xu HE, et al. Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science (New York, N.Y.). eadd6220. PMID 36862765 DOI: 10.1126/science.add6220 |
0.312 |
|
| 2023 |
Duan J, Xu P, Zhang H, Luan X, Yang J, He X, Mao C, Shen DD, Ji Y, Cheng X, Jiang H, Jiang Y, Zhang S, Zhang Y, Xu HE. Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor. Nature Communications. 14: 519. PMID 36720854 DOI: 10.1038/s41467-023-36170-3 |
0.716 |
|
| 2023 |
Wang Y, Zhuang Y, DiBerto JF, Zhou XE, Schmitz GP, Yuan Q, Jain MK, Liu W, Melcher K, Jiang Y, Roth BL, Xu HE. Structures of the entire human opioid receptor family. Cell. PMID 36638794 DOI: 10.1016/j.cell.2022.12.026 |
0.308 |
|
| 2022 |
Cai H, Xu Y, Guo S, He X, Sun J, Li X, Li C, Yin W, Cheng X, Jiang H, Xu HE, Xie X, Jiang Y. Structures of adenosine receptor AR bound to endogenous and synthetic agonists. Cell Discovery. 8: 140. PMID 36575181 DOI: 10.1038/s41421-022-00503-1 |
0.33 |
|
| 2022 |
Zhao LH, Yuan QN, Dai AT, He XH, Chen CW, Zhang C, Xu YW, Zhou Y, Wang MW, Yang DH, Xu HE. Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1. Acta Pharmacologica Sinica. PMID 36482086 DOI: 10.1038/s41401-022-01032-z |
0.357 |
|
| 2022 |
Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, ... ... Xu HE, et al. Molecular recognition of morphine and fentanyl by the human μ-opioid receptor. Cell. 185: 4361-4375.e19. PMID 36368306 DOI: 10.1016/j.cell.2022.09.041 |
0.389 |
|
| 2022 |
Zhao LH, Lin J, Ji SY, Zhou XE, Mao C, Shen DD, He X, Xiao P, Sun J, Melcher K, Zhang Y, Yu X, Xu HE. Structure insights into selective coupling of G protein subtypes by a class B G protein-coupled receptor. Nature Communications. 13: 6670. PMID 36335102 DOI: 10.1038/s41467-022-33851-3 |
0.307 |
|
| 2022 |
Xu P, Huang S, Guo S, Yun Y, Cheng X, He X, Cai P, Lan Y, Zhou H, Jiang H, Jiang Y, Xie X, Xu HE. Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119. Nature Structural & Molecular Biology. PMID 35970999 DOI: 10.1038/s41594-022-00816-5 |
0.744 |
|
| 2022 |
Duan J, Xu P, Luan X, Ji Y, He X, Song N, Yuan Q, Jin Y, Cheng X, Jiang H, Zheng J, Zhang S, Jiang Y, Xu HE. Hormone- and antibody-mediated activation of the thyrotropin receptor. Nature. PMID 35940204 DOI: 10.1038/s41586-022-05173-3 |
0.708 |
|
| 2022 |
He XH, You CZ, Jiang HL, Jiang Y, Xu HE, Cheng X. AlphaFold2 versus experimental structures: evaluation on G protein-coupled receptors. Acta Pharmacologica Sinica. PMID 35778488 DOI: 10.1038/s41401-022-00938-y |
0.373 |
|
| 2022 |
Huang S, Xu P, Shen DD, Simon IA, Mao C, Tan Y, Zhang H, Harpsøe K, Li H, Zhang Y, You C, Yu X, Jiang Y, Zhang Y, Gloriam DE, ... Xu HE, et al. GPCRs steer G and G selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors. Molecular Cell. PMID 35714614 DOI: 10.1016/j.molcel.2022.05.031 |
0.71 |
|
| 2022 |
Tan Y, Xu P, Huang S, Yang G, Zhou F, He X, Ma H, Xu HE, Jiang Y. Structural insights into the ligand binding and G coupling of serotonin receptor 5-HT. Cell Discovery. 8: 50. PMID 35610220 DOI: 10.1038/s41421-022-00412-3 |
0.698 |
|
| 2022 |
Shao Z, Tan Y, Shen Q, Hou L, Yao B, Qin J, Xu P, Mao C, Chen LN, Zhang H, Shen DD, Zhang C, Li W, Du X, Li F, ... ... Xu HE, et al. Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3. Cell Discovery. 8: 44. PMID 35570218 DOI: 10.1038/s41421-022-00403-4 |
0.752 |
|
| 2022 |
Xu Y, Feng W, Zhou Q, Liang A, Li J, Dai A, Zhao F, Yan J, Chen CW, Li H, Zhao LH, Xia T, Jiang Y, Xu HE, Yang D, et al. A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2. Nature Communications. 13: 2272. PMID 35477937 DOI: 10.1038/s41467-022-30041-z |
0.366 |
|
| 2022 |
Ping YQ, Xiao P, Yang F, Zhao RJ, Guo SC, Yan X, Wu X, Zhang C, Lu Y, Zhao F, Zhou F, Xi YT, Yin W, Liu FZ, He DF, ... ... Xu HE, et al. Structural basis for the tethered peptide activation of adhesion GPCRs. Nature. PMID 35418678 DOI: 10.1038/s41586-022-04619-y |
0.338 |
|
| 2022 |
Xu Y, Cai H, You C, He X, Yuan Q, Jiang H, Cheng X, Jiang Y, Xu HE. Structural insights into ligand binding and activation of the human thyrotropin-releasing hormone receptor. Cell Research. PMID 35365755 DOI: 10.1038/s41422-022-00641-x |
0.333 |
|
| 2022 |
Zhuang Y, Wang L, Guo J, Sun D, Wang Y, Liu W, Xu HE, Zhang C. Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2. Nature Communications. 13: 1054. PMID 35217703 DOI: 10.1038/s41467-022-28586-0 |
0.463 |
|
| 2022 |
Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, ... ... Xu HE, et al. Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors. Nature Communications. 13: 1057. PMID 35217653 DOI: 10.1038/s41467-022-28683-0 |
0.642 |
|
| 2022 |
Xu H, Tilley DG. Pepducin-mediated G Protein-Coupled Receptor Signaling in the Cardiovascular System. Journal of Cardiovascular Pharmacology. 80: 378-385. PMID 35170495 DOI: 10.1097/FJC.0000000000001236 |
0.387 |
|
| 2022 |
Yin W, Xu Y, Xu P, Cao X, Wu C, Gu C, He X, Wang X, Huang S, Yuan Q, Wu K, Hu W, Huang Z, Liu J, Wang Z, ... ... Xu HE, et al. Structures of the Omicron Spike trimer with ACE2 and an anti-Omicron antibody. Science (New York, N.Y.). eabn8863. PMID 35133176 DOI: 10.1126/science.abn8863 |
0.639 |
|
| 2022 |
Cong Z, Liang YL, Zhou Q, Darbalaei S, Zhao F, Feng W, Zhao L, Xu HE, Yang D, Wang MW. Structural perspective of class B1 GPCR signaling. Trends in Pharmacological Sciences. PMID 35078643 DOI: 10.1016/j.tips.2022.01.002 |
0.415 |
|
| 2021 |
Shao Z, Shen Q, Yao B, Mao C, Chen LN, Zhang H, Shen DD, Zhang C, Li W, Du X, Li F, Ma H, Chen ZH, Xu HE, Ying S, et al. Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1. Nature Chemical Biology. PMID 34949837 DOI: 10.1038/s41589-021-00918-z |
0.42 |
|
| 2021 |
Cong Z, Zhou F, Zhang C, Zou X, Zhang H, Wang Y, Zhou Q, Cai X, Liu Q, Li J, Shao L, Mao C, Wang X, Wu J, Xia T, ... ... Xu HE, et al. Constitutive signal bias mediated by the human GHRHR splice variant 1. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34599099 DOI: 10.1073/pnas.2106606118 |
0.316 |
|
| 2021 |
Zhang X, He C, Wang M, Zhou Q, Yang D, Zhu Y, Feng W, Zhang H, Dai A, Chu X, Wang J, Yang Z, Jiang Y, Sensfuss U, Tan Q, ... ... Xu HE, et al. Structures of the human cholecystokinin receptors bound to agonists and antagonists. Nature Chemical Biology. PMID 34556863 DOI: 10.1038/s41589-021-00866-8 |
0.397 |
|
| 2021 |
Liu Q, Yang D, Zhuang Y, Croll TI, Cai X, Dai A, He X, Duan J, Yin W, Ye C, Zhou F, Wu B, Zhao Q, Xu HE, Wang MW, et al. Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor. Nature Chemical Biology. PMID 34556862 DOI: 10.1038/s41589-021-00841-3 |
0.354 |
|
| 2021 |
Duan J, Xu P, Cheng X, Mao C, Croll T, He X, Shi J, Luan X, Yin W, You E, Liu Q, Zhang S, Jiang H, Zhang Y, Jiang Y, ... Xu HE, et al. Structures of full-length glycoprotein hormone receptor signalling complexes. Nature. PMID 34552239 DOI: 10.1038/s41586-021-03924-2 |
0.745 |
|
| 2021 |
Yin YL, Ye C, Zhou F, Wang J, Yang D, Yin W, Wang MW, Xu HE, Jiang Y. Molecular basis for kinin selectivity and activation of the human bradykinin receptors. Nature Structural & Molecular Biology. 28: 755-761. PMID 34518695 DOI: 10.1038/s41594-021-00645-y |
0.396 |
|
| 2021 |
Ma S, Chen Y, Dai A, Yin W, Guo J, Yang D, Zhou F, Jiang Y, Wang MW, Xu HE. Structural mechanism of calcium-mediated hormone recognition and Gβ interaction by the human melanocortin-1 receptor. Cell Research. PMID 34453129 DOI: 10.1038/s41422-021-00557-y |
0.413 |
|
| 2021 |
Wang Y, Guo S, Zhuang Y, Yun Y, Xu P, He X, Guo J, Yin W, Xu HE, Xie X, Jiang Y. Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor. Nature Communications. 12: 5064. PMID 34417468 DOI: 10.1038/s41467-021-25364-2 |
0.738 |
|
| 2021 |
Wang X, Cheng X, Zhao L, Wang Y, Ye C, Zou X, Dai A, Cong Z, Chen J, Zhou Q, Xia T, Jiang H, Xu HE, Yang D, Wang MW. Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34353904 DOI: 10.1073/pnas.2101279118 |
0.397 |
|
| 2021 |
Huang S, Xu P, Tan Y, You C, Zhang Y, Jiang Y, Xu HE. Structural basis for recognition of anti-migraine drug lasmiditan by the serotonin receptor 5-HT-G protein complex. Cell Research. PMID 34239069 DOI: 10.1038/s41422-021-00527-4 |
0.694 |
|
| 2021 |
Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harpsøe K, Svensson B, Guo J, Jiang H, Gloriam DE, ... ... Xu HE, et al. Structural insights into the lipid and ligand regulation of serotonin receptors. Nature. PMID 33762731 DOI: 10.1038/s41586-021-03376-8 |
0.662 |
|
| 2021 |
Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, ... ... Xu HE, et al. Structural insights into the human D1 and D2 dopamine receptor signaling complexes. Cell. PMID 33571431 DOI: 10.1016/j.cell.2021.01.027 |
0.724 |
|
| 2021 |
Xu P, Huang S, Mao C, Krumm BE, Zhou XE, Tan Y, Huang XP, Liu Y, Shen DD, Jiang Y, Yu X, Jiang H, Melcher K, Roth BL, Cheng X, ... ... Xu HE, et al. Structures of the human dopamine D3 receptor-G complexes. Molecular Cell. PMID 33548201 DOI: 10.1016/j.molcel.2021.01.003 |
0.736 |
|
| 2021 |
Ping YQ, Mao C, Xiao P, Zhao RJ, Jiang Y, Yang Z, An WT, Shen DD, Yang F, Zhang H, Qu C, Shen Q, Tian C, Li ZJ, Li S, ... ... Xu HE, et al. Structures of the glucocorticoid-bound adhesion receptor GPR97-G complex. Nature. PMID 33408414 DOI: 10.1038/s41586-020-03083-w |
0.414 |
|
| 2020 |
Sun W, Chen LN, Zhou Q, Zhao LH, Yang D, Zhang H, Cong Z, Shen DD, Zhao F, Zhou F, Cai X, Chen Y, Zhou Y, Gadgaard S, van der Velden WJC, ... ... Xu HE, et al. A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor. Cell Research. PMID 33239759 DOI: 10.1038/s41422-020-00442-0 |
0.356 |
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| 2020 |
Duan J, Shen DD, Zhou XE, Bi P, Liu QF, Tan YX, Zhuang YW, Zhang HB, Xu PY, Huang SJ, Ma SS, He XH, Melcher K, Zhang Y, Xu HE, et al. Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy. Nature Communications. 11: 4121. PMID 32807782 DOI: 10.1038/S41467-020-17933-8 |
0.777 |
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| 2020 |
Ma H, Huang W, Wang X, Zhao L, Jiang Y, Liu F, Guo W, Sun X, Zhong W, Yuan D, Xu HE. Structural insights into the activation of GLP-1R by a small molecule agonist. Cell Research. PMID 32724086 DOI: 10.1038/S41422-020-0384-8 |
0.306 |
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| 2020 |
Jiang Y, Xu HE. GABA receptor pas de deux: insights from high-resolution structures. Cell Research. PMID 32651455 DOI: 10.1038/S41422-020-0373-Y |
0.386 |
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| 2020 |
Wang L, Cheng CM, Qin J, Xu M, Kao CY, Shi J, You E, Gong W, Rosa LP, Chase P, Scampavia L, Madoux F, Spicer T, Hodder P, Xu HE, et al. Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment. Science Advances. 6: eaaz8031. PMID 32494682 DOI: 10.1126/Sciadv.Aaz8031 |
0.313 |
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| 2020 |
de Waal PW, Shi J, You E, Wang X, Melcher K, Jiang Y, Xu HE, Dickson BM. Molecular mechanisms of fentanyl mediated β-arrestin biased signaling. Plos Computational Biology. 16: e1007394. PMID 32275713 DOI: 10.1371/Journal.Pcbi.1007394 |
0.764 |
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| 2020 |
Jiang H, Zhou XE, Shi J, Zhou Z, Zhao G, Zhang X, Sun Y, Suino-Powell K, Ma L, Gao H, Yu X, Li J, Li J, Melcher K, Xu HE, et al. Identification and structural insight of an effective PPARγ modulator with improved therapeutic index for anti-diabetic drug discovery. Chemical Science. 11: 2260-2268. PMID 32190280 DOI: 10.1039/C9Sc05487A |
0.348 |
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| 2020 |
Zhou Y, Zhou XE, Gong Y, Zhu Y, Cao X, Brunzelle JS, Xu HE, Zhou M, Melcher K, Zhang F. Structural basis of Fusarium myosin I inhibition by phenamacril. Plos Pathogens. 16: e1008323. PMID 32163521 DOI: 10.1371/Journal.Ppat.1008323 |
0.318 |
|
| 2020 |
Ma S, Shen Q, Zhao LH, Mao C, Zhou XE, Shen DD, de Waal PW, Bi P, Li C, Jiang Y, Wang MW, Sexton PM, Wootten D, Melcher K, Zhang Y, ... Xu HE, et al. Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors. Molecular Cell. PMID 32004470 DOI: 10.1016/J.Molcel.2020.01.013 |
0.803 |
|
| 2020 |
Liang YL, Belousoff MJ, Zhao P, Koole C, Fletcher MM, Truong TT, Julita V, Christopoulos G, Xu HE, Zhang Y, Khoshouei M, Christopoulos A, Danev R, Sexton PM, Wootten D. Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation. Molecular Cell. PMID 32004469 DOI: 10.1016/J.Molcel.2020.01.012 |
0.493 |
|
| 2020 |
Xing C, Zhuang Y, Xu TH, Feng Z, Zhou XE, Chen M, Wang L, Meng X, Xue Y, Wang J, Liu H, McGuire TF, Zhao G, Melcher K, Zhang C, ... Xu HE, et al. Cryo-EM Structure of the Human Cannabinoid Receptor CB2-G Signaling Complex. Cell. PMID 32004460 DOI: 10.1016/J.Cell.2020.01.007 |
0.491 |
|
| 2019 |
Dutka P, Mukherjee S, Gao X, Kang Y, de Waal PW, Wang L, Zhuang Y, Melcher K, Zhang C, Xu HE, Kossiakoff AA. Development of "Plug and Play" Fiducial Marks for Structural Studies of GPCR Signaling Complexes by Single-Particle Cryo-EM. Structure (London, England : 1993). PMID 31669042 DOI: 10.1016/J.Str.2019.10.004 |
0.777 |
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| 2019 |
Shi Y, Wang T, Zhou XE, Liu QF, Jiang Y, Xu HE. Structure-based design of a hyperthermostable AgUricase for hyperuricemia and gout therapy. Acta Pharmacologica Sinica. PMID 31253939 DOI: 10.1038/S41401-019-0269-X |
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| 2019 |
Zhao LH, Ma S, Sutkeviciute I, Shen DD, Zhou XE, de Waal PW, Li CY, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, ... ... Xu HE, et al. Structure and dynamics of the active human parathyroid hormone receptor-1. Science (New York, N.Y.). 364: 148-153. PMID 30975883 DOI: 10.1126/science.aav7942 |
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| 2019 |
Liu P, Yin YL, Wang T, Hou L, Wang XX, Wang M, Zhao GG, Shi Y, Xu HE, Jiang Y. Ligand-induced activation of ERK1/2 signaling by constitutively active G-coupled 5-HT receptors. Acta Pharmacologica Sinica. PMID 30833707 DOI: 10.1038/S41401-018-0204-6 |
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| 2019 |
Zhao LH, Ma S, Sutkeviciute I, Shen DD, Zhou XE, Waal PWd, Li CY, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, ... ... Xu HE, et al. Structure and dynamics of the active human parathyroid hormone receptor-1. Science. 364: 148-153. DOI: 10.2210/Pdb6Nbf/Pdb |
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| 2019 |
Sutkeviciute I, Zhao L, Zhang Y, Xu HE, Vilardaga J. OR30-3 Structural Basis of Activation and Sustained Signaling by the PTH Receptor Journal of the Endocrine Society. 3. DOI: 10.1210/Js.2019-Or30-3 |
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| 2018 |
Yan Y, Zhou XE, Xu HE, Melcher K. Structure and Physiological Regulation of AMPK. International Journal of Molecular Sciences. 19. PMID 30423971 DOI: 10.3390/Ijms19113534 |
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| 2018 |
Zhou XE, Melcher K, Xu HE. Structural biology of G protein-coupled receptor signaling complexes. Protein Science : a Publication of the Protein Society. PMID 30311978 DOI: 10.1002/Pro.3526 |
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| 2018 |
Gu X, Bridges MD, Yan Y, de Waal P, Zhou XE, Suino-Powell KM, Xu HE, Hubbell WL, Melcher K. Conformational heterogeneity of the allosteric drug and metabolite (ADaM) site in AMP-activated protein kinase (AMPK). The Journal of Biological Chemistry. PMID 30206123 DOI: 10.1074/Jbc.Ra118.004101 |
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| 2018 |
Yang S, Wu Y, Xu TH, de Waal PW, He Y, Pu M, Chen Y, DeBruine ZJ, Zhang B, Zaidi SA, Popov P, Guo Y, Han GW, Lu Y, Suino-Powell K, ... ... Xu HE, et al. Crystal structure of the Frizzled 4 receptor in a ligand-free state. Nature. PMID 30135577 DOI: 10.1038/S41586-018-0447-X |
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| 2018 |
Byun S, Kim DH, Ryerson D, Kim YC, Sun H, Kong B, Yau P, Guo G, Xu HE, Kemper B, Kemper JK. Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis. Nature Communications. 9: 2590. PMID 29968724 DOI: 10.1038/S41467-018-04697-5 |
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| 2018 |
Kang Y, Kuybeda O, de Waal PW, Mukherjee S, Van Eps N, Dutka P, Zhou XE, Bartesaghi A, Erramilli S, Morizumi T, Gu X, Yin Y, Liu P, Jiang Y, Meng X, ... ... Xu HE, et al. Publisher Correction: Cryo-EM structure of human rhodopsin bound to an inhibitory G protein. Nature. PMID 29930353 DOI: 10.1038/S41586-018-0302-0 |
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| 2018 |
Kang Y, Kuybeda O, de Waal PW, Mukherjee S, Van Eps N, Dutka P, Zhou XE, Bartesaghi A, Erramilli S, Morizumi T, Gu X, Yin Y, Liu P, Jiang Y, Meng X, ... ... Xu HE, et al. Cryo-EM structure of human rhodopsin bound to an inhibitory G protein. Nature. PMID 29899450 DOI: 10.1038/S41586-018-0215-Y |
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| 2018 |
Latorraca NR, Wang JK, Bauer B, Townshend RJL, Hollingsworth SA, Olivieri JE, Xu HE, Sommer ME, Dror RO. Molecular mechanism of GPCR-mediated arrestin activation. Nature. PMID 29720655 DOI: 10.1038/S41586-018-0077-3 |
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| 2018 |
Yin W, Zhou XE, Yang D, de Waal PW, Wang M, Dai A, Cai X, Huang CY, Liu P, Wang X, Yin Y, Liu B, Zhou Y, Wang J, Liu H, ... ... Xu HE, et al. Crystal structure of the human 5-HTserotonin receptor bound to an inverse agonist. Cell Discovery. 4: 12. PMID 29560272 DOI: 10.1038/S41421-018-0009-2 |
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| 2017 |
Cao MJ, Zhang YL, Liu X, Huang H, Zhou XE, Wang WL, Zeng A, Zhao CZ, Si T, Du J, Wu WW, Wang FX, Xu HE, Zhu JK. Combining chemical and genetic approaches to increase drought resistance in plants. Nature Communications. 8: 1183. PMID 29084945 DOI: 10.1038/S41467-017-01239-3 |
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| 2017 |
Ren Z, Wang Z, Zhou XE, Shi H, Hong Y, Cao M, Chan Z, Liu X, Xu HE, Zhu JK. Structure determination and activity manipulation of the turfgrass ABA receptor FePYR1. Scientific Reports. 7: 14022. PMID 29070857 DOI: 10.1038/S41598-017-14101-9 |
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| 2017 |
DeBruine ZJ, Xu HE, Melcher K. Assembly and architecture of the Wnt/β-catenin signalosome at the membrane. British Journal of Pharmacology. PMID 28941231 DOI: 10.1111/bph.14048 |
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| 2017 |
Zhou XE, He Y, de Waal PW, Gao X, Kang Y, Van Eps N, Yin Y, Pal K, Goswami D, White TA, Barty A, Latorraca NR, Chapman HN, Hubbell WL, Dror RO, ... ... Xu HE, et al. Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors. Cell. 170: 457-469.e13. PMID 28753425 DOI: 10.1016/J.Cell.2017.07.002 |
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| 2017 |
Ma H, Duan J, Ke J, He Y, Gu X, Xu TH, Yu H, Wang Y, Brunzelle JS, Jiang Y, Rothbart SB, Xu HE, Li J, Melcher K. A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex. Science Advances. 3: e1601217. PMID 28630893 DOI: 10.1126/Sciadv.1601217 |
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| 2017 |
Gu X, Yan Y, Novick SJ, Kovich A, Goswami D, Ke J, Tan MHE, Wang L, Li X, de Waal P, Webb MR, Griffin PR, Xu HE, Melcher K. Deconvoluting AMP-dependent kinase (AMPK) adenine nucleotide binding and sensing. The Journal of Biological Chemistry. PMID 28615457 DOI: 10.1074/Jbc.M117.793018 |
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| 2017 |
Zhou XE, Melcher K, Xu HE. Understanding the GPCR biased signaling through G protein and arrestin complex structures. Current Opinion in Structural Biology. 45: 150-159. PMID 28558341 DOI: 10.1016/J.Sbi.2017.05.004 |
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| 2017 |
DeBruine ZJ, Ke J, Harikumar KG, Gu X, Borowsky P, Williams BO, Xu W, Miller LJ, Xu HE, Melcher K. Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization. Genes & Development. PMID 28546512 DOI: 10.1101/Gad.298331.117 |
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| 2017 |
Vishnivetskiy SA, Lee RJ, Zhou XE, Franz A, Xu Q, Xu HE, Gurevich VV. Functional role of the three conserved cysteines in the N-domain of visual arrestin-1. The Journal of Biological Chemistry. PMID 28536260 DOI: 10.1074/Jbc.M117.790386 |
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| 2017 |
Pal K, Bandyopadhyay A, Zhou XE, Xu Q, Marciano DP, Brunzelle JS, Yerrum S, Griffin PR, Vande Woude G, Melcher K, Xu HE. Structural Basis of TPR-Mediated Oligomerization and Activation of Oncogenic Fusion Kinases. Structure (London, England : 1993). PMID 28528776 DOI: 10.1016/J.Str.2017.04.015 |
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| 2017 |
He Y, Gao X, Goswami D, Hou L, Pal K, Yin Y, Zhao G, Ernst OP, Griffin P, Melcher K, Xu HE. Molecular assembly of rhodopsin with G protein-coupled receptor kinases. Cell Research. PMID 28524165 DOI: 10.1038/Cr.2017.72 |
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| 2017 |
Shi Y, Wang XX, Zhuang YW, Jiang Y, Melcher K, Xu HE. Structure of the PRC2 complex and application to drug discovery. Acta Pharmacologica Sinica. PMID 28414199 DOI: 10.1038/Aps.2017.7 |
0.309 |
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| 2017 |
Yin Y, de Waal P, He Y, Zhao LH, Yang D, Cai X, Jiang Y, Melcher K, Wang MW, Xu HE. Rearrangement of a polar core provides a conserved mechanism for constitutive activation of class B G protein-coupled receptors. The Journal of Biological Chemistry. PMID 28356352 DOI: 10.1074/Jbc.M117.782987 |
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| 2017 |
Chen YN, Gu X, Zhou XE, Wang W, Cheng D, Ge Y, Ye F, Xu HE, Lv Z. Crystal Structure of TBC1D15 GTPase-activating Protein (GAP) Domain and its Activity on Rab GTPases. Protein Science : a Publication of the Protein Society. PMID 28168758 DOI: 10.1002/Pro.3132 |
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| 2017 |
Zhang F, Ke J, Zhang L, Chen R, Sugimoto K, Howe GA, Xu HE, Zhou M, He SY, Melcher K. Structural insights into alternative splicing-mediated desensitization of jasmonate signaling. Proceedings of the National Academy of Sciences of the United States of America. PMID 28137867 DOI: 10.1073/Pnas.1616938114 |
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| 2017 |
Yi W, Shi J, Zhao G, Zhou XE, Suino-Powell K, Melcher K, Xu HE. Identification of a novel selective PPARγ ligand with a unique binding mode and improved therapeutic profile in vitro. Scientific Reports. 7: 41487. PMID 28128331 DOI: 10.1038/Srep41487 |
0.419 |
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| 2016 |
Yin Y, Zhou XE, Hou L, Zhao LH, Liu B, Wang G, Jiang Y, Melcher K, Xu HE. An intrinsic agonist mechanism for activation of glucagon-like peptide-1 receptor by its extracellular domain. Cell Discovery. 2: 16042. PMID 27917297 DOI: 10.1038/Celldisc.2016.42 |
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| 2016 |
Dickson BM, de Waal PW, Ramjan ZH, Xu HE, Rothbart SB. A fast, open source implementation of adaptive biasing potentials uncovers a ligand design strategy for the chromatin regulator BRD4. The Journal of Chemical Physics. 145: 154113. PMID 27782467 DOI: 10.1063/1.4964776 |
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| 2016 |
Liu P, Jia MZ, Zhou XE, De Waal PW, Dickson BM, Liu B, Hou L, Yin YT, Kang YY, Shi Y, Melcher K, Xu HE, Jiang Y. The structural basis of the dominant negative phenotype of the Gαi1β1γ2 G203A/A326S heterotrimer. Acta Pharmacologica Sinica. PMID 27498775 DOI: 10.1038/Aps.2016.69 |
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| 2016 |
Golani LK, Wallace-Povirk A, Deis SM, Wong JE, Ke J, Gu X, Raghavan S, Wilson MR, Li X, Polin LA, de Waal PW, White K, Kushner J, O'Connor CE, Hou Z, ... Xu HE, et al. Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions Via Cellular Uptake by Folate Receptor α and the Proton-coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis. Journal of Medicinal Chemistry. PMID 27458733 DOI: 10.1021/Acs.Jmedchem.6B00594 |
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| 2016 |
Zhao LH, Yin Y, Yang D, Liu B, Hou L, Wang X, Pal K, Jiang Y, Feng Y, Cai X, Dai A, Liu M, Wang MW, Melcher K, Xu HE. Differential Requirement of the Extracellular Domain in Activation of Class B G Protein-Coupled Receptors. The Journal of Biological Chemistry. PMID 27226600 DOI: 10.1074/Jbc.M116.726620 |
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| 2016 |
Zhou XE, Gao X, Barty A, Kang Y, He Y, Liu W, Ishchenko A, White TA, Yefanov O, Han GW, Xu Q, de Waal PW, Suino-Powell KM, Boutet S, Williams GJ, ... ... Xu HE, et al. X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex. Scientific Data. 3: 160021. PMID 27070998 DOI: 10.1038/Sdata.2016.21 |
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| 2016 |
Zhi X, Zhou XE, Melcher K, Xu HE. Structures and regulation of non-X orphan nuclear receptors: A retinoid hypothesis. The Journal of Steroid Biochemistry and Molecular Biology. 157: 27-40. PMID 26159912 DOI: 10.1016/J.Jsbmb.2015.06.012 |
0.458 |
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| 2015 |
Ke J, Ma H, Gu X, Thelen A, Brunzelle JS, Li J, Xu HE, Melcher K. Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors. Science Advances. 1: e1500107. PMID 26601214 DOI: 10.1126/Sciadv.1500107 |
0.377 |
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| 2015 |
Fu T, Kim YC, Byun S, Kim DH, Seok S, Suino-Powell K, Xu HE, Kemper B, Kemper JK. FXR primes the liver for intestinal FGF15 signaling by transient induction of βKlotho. Molecular Endocrinology (Baltimore, Md.). me20151226. PMID 26505219 DOI: 10.1210/Me.2015-1226 |
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| 2015 |
Zhao LH, Zhou XE, Yi W, Wu Z, Liu Y, Kang Y, Hou L, de Waal PW, Li S, Jiang Y, Scaffidi A, Flematti GR, Smith SM, Lam VQ, Griffin PR, ... ... Xu HE, et al. Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-ligase signaling effector DWARF3. Cell Research. PMID 26470846 DOI: 10.1038/Cr.2015.122 |
0.74 |
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| 2015 |
Kang Y, Gao X, Zhou XE, He Y, Melcher K, Xu HE. A structural snapshot of the rhodopsin-arrestin complex. The Febs Journal. PMID 26467309 DOI: 10.1111/Febs.13561 |
0.455 |
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| 2015 |
Zhang F, Yao J, Ke J, Zhang L, Lam VQ, Xin XF, Zhou XE, Chen J, Brunzelle J, Griffin PR, Zhou M, Xu HE, Melcher K, He SY. Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling. Nature. PMID 26258305 DOI: 10.1038/Nature14661 |
0.396 |
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| 2015 |
Wu ZS, Cheng H, Jiang Y, Melcher K, Xu HE. Ion channels gated by acetylcholine and serotonin: structures, biology, and drug discovery. Acta Pharmacologica Sinica. 36: 895-907. PMID 26238288 DOI: 10.1038/Aps.2015.66 |
0.362 |
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| 2015 |
Shen G, Ke J, Wang Z, Cheng Z, Gu X, Wei Y, Melcher K, Xu HE, Xu W. Structural basis of the Norrin-Frizzled 4 interaction. Cell Research. 25: 1078-81. PMID 26227961 DOI: 10.1038/Cr.2015.92 |
0.305 |
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| 2015 |
Kang Y, Zhou XE, Gao X, He Y, Liu W, Ishchenko A, Barty A, White TA, Yefanov O, Han GW, Xu Q, de Waal PW, Ke J, Tan MH, Zhang C, ... ... Xu HE, et al. Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser. Nature. PMID 26200343 DOI: 10.1038/Nature14656 |
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| 2015 |
Wu ZS, Cui ZC, Cheng H, Fan C, Melcher K, Jiang Y, Zhang CH, Jiang HL, Cong Y, Liu Q, Xu HE. High yield and efficient expression and purification of the human 5-HT3A receptor. Acta Pharmacologica Sinica. PMID 26073329 DOI: 10.1038/Aps.2015.35 |
0.351 |
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| 2015 |
Cheng H, Fan C, Zhang SW, Wu ZS, Cui ZC, Melcher K, Zhang CH, Jiang Y, Cong Y, Xu HE. Crystallization scale purification of α7 nicotinic acetylcholine receptor from mammalian cells using a BacMam expression system. Acta Pharmacologica Sinica. PMID 26073323 DOI: 10.1038/Aps.2015.34 |
0.339 |
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| 2015 |
Sun F, Indran IR, Zhang ZW, Tan MH, Li Y, Lim ZL, Hua R, Yang C, Soon FF, Li J, Xu HE, Cheung E, Yong EL. A novel prostate cancer therapeutic strategy using icaritin-activated arylhydrocarbon-receptor to co-target androgen receptor and its splice variants. Carcinogenesis. 36: 757-68. PMID 25908644 DOI: 10.1093/Carcin/Bgv040 |
0.337 |
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| 2015 |
Zhi X, Zhou XE, He Y, Searose-Xu K, Zhang CL, Tsai CC, Melcher K, Xu HE. Structural basis for corepressor assembly by the orphan nuclear receptor TLX. Genes & Development. 29: 440-50. PMID 25691470 DOI: 10.1101/Gad.254904.114 |
0.461 |
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| 2015 |
Qin Y, Ke J, Gu X, Fang J, Wang W, Cong Q, Li J, Tan J, Brunzelle JS, Zhang C, Jiang Y, Melcher K, Li JP, Xu HE, Ding K. Structural and functional study of D-glucuronyl C5-epimerase. The Journal of Biological Chemistry. 290: 4620-30. PMID 25568314 DOI: 10.1074/Jbc.M114.602201 |
0.372 |
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| 2015 |
Xu HE. Family reunion of nuclear hormone receptors: structures, diseases, and drug discovery. Acta Pharmacologica Sinica. 36: 1-2. PMID 25557215 DOI: 10.1038/Aps.2014.140 |
0.456 |
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| 2015 |
Li X, Wang L, Zhou XE, Ke J, de Waal PW, Gu X, Tan MH, Wang D, Wu D, Xu HE, Melcher K. Structural basis of AMPK regulation by adenine nucleotides and glycogen. Cell Research. 25: 50-66. PMID 25412657 DOI: 10.1038/Cr.2014.150 |
0.75 |
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| 2015 |
Tan MH, Li J, Xu HE, Melcher K, Yong EL. Androgen receptor: structure, role in prostate cancer and drug discovery. Acta Pharmacologica Sinica. 36: 3-23. PMID 24909511 DOI: 10.1038/Aps.2014.18 |
0.336 |
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| 2014 |
Li S, Hsu DD, Li B, Luo X, Alderson N, Qiao L, Ma L, Zhu HH, He Z, Suino-Powell K, Ji K, Li J, Shao J, Xu HE, Li T, et al. Cytoplasmic tyrosine phosphatase Shp2 coordinates hepatic regulation of bile acid and FGF15/19 signaling to repress bile acid synthesis. Cell Metabolism. 20: 320-32. PMID 24981838 DOI: 10.1016/J.Cmet.2014.05.020 |
0.362 |
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| 2014 |
Ng LM, Melcher K, Teh BT, Xu HE. Abscisic acid perception and signaling: structural mechanisms and applications. Acta Pharmacologica Sinica. 35: 567-84. PMID 24786231 DOI: 10.1038/Aps.2014.5 |
0.337 |
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| 2014 |
He Y, Yi W, Suino-Powell K, Zhou XE, Tolbert WD, Tang X, Yang J, Yang H, Shi J, Hou L, Jiang H, Melcher K, Xu HE. Structures and mechanism for the design of highly potent glucocorticoids. Cell Research. 24: 713-26. PMID 24763108 DOI: 10.1038/cr.2014.52 |
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| 2014 |
Zhi X, Zhou XE, He Y, Zechner C, Suino-Powell KM, Kliewer SA, Melcher K, Mangelsdorf DJ, Xu HE. Structural insights into gene repression by the orphan nuclear receptor SHP. Proceedings of the National Academy of Sciences of the United States of America. 111: 839-44. PMID 24379397 DOI: 10.1073/Pnas.1322827111 |
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| 2014 |
Xu HE. Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser Acta Crystallographica Section a Foundations and Advances. 70: C567-C567. DOI: 10.1107/S2053273314094327 |
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| 2014 |
Zhi X, Zhou XE, He Y, Zechner C, Suino-Powell KM, Kliewer SA, Melcher K, Mangelsdorf DJ, Xu HE. Erratum: Structural insights into gene repression by the orphan nuclear receptor SHP (Proceedings of the National Academy of Sciences of the United States of America (2014) 111 (839-844) DOI: 10.1073/pnas.1322827111) Proceedings of the National Academy of Sciences of the United States of America. 111. DOI: 10.1073/Pnas.1402462111 |
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| 2013 |
Pal K, Melcher K, Xu HE. Structure modeling using genetically engineered crosslinking. Cell. 155: 1207-8. PMID 24315089 DOI: 10.1016/J.Cell.2013.11.018 |
0.465 |
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| 2013 |
Ke J, Harikumar KG, Erice C, Chen C, Gu X, Wang L, Parker N, Cheng Z, Xu W, Williams BO, Melcher K, Miller LJ, Xu HE. Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex. Genes & Development. 27: 2305-19. PMID 24186977 DOI: 10.1101/Gad.228544.113 |
0.44 |
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| 2013 |
Tan MH, Zhou XE, Soon FF, Li X, Li J, Yong EL, Melcher K, Xu HE. The crystal structure of the orphan nuclear receptor NR2E3/PNR ligand binding domain reveals a dimeric auto-repressed conformation. Plos One. 8: e74359. PMID 24069298 DOI: 10.1371/Journal.Pone.0074359 |
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| 2013 |
Chen C, Ke J, Zhou XE, Yi W, Brunzelle JS, Li J, Yong EL, Xu HE, Melcher K. Structural basis for molecular recognition of folic acid by folate receptors. Nature. 500: 486-9. PMID 23851396 DOI: 10.1038/Nature12327 |
0.473 |
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| 2013 |
Cao M, Liu X, Zhang Y, Xue X, Zhou XE, Melcher K, Gao P, Wang F, Zeng L, Zhao Y, Zhao Y, Deng P, Zhong D, Zhu JK, Xu HE, et al. An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants. Cell Research. 23: 1043-54. PMID 23835477 DOI: 10.1038/Cr.2013.95 |
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| 2013 |
Seok S, Kanamaluru D, Xiao Z, Ryerson D, Choi SE, Suino-Powell K, Xu HE, Veenstra TD, Kemper JK. Bile acid signal-induced phosphorylation of small heterodimer partner by protein kinase Cζ is critical for epigenomic regulation of liver metabolic genes. The Journal of Biological Chemistry. 288: 23252-63. PMID 23824184 DOI: 10.1074/Jbc.M113.452037 |
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| 2013 |
Wacker D, Wang C, Katritch V, Han GW, Huang XP, Vardy E, McCorvy JD, Jiang Y, Chu M, Siu FY, Liu W, Xu HE, Cherezov V, Roth BL, Stevens RC. Structural features for functional selectivity at serotonin receptors. Science (New York, N.Y.). 340: 615-9. PMID 23519215 DOI: 10.1126/Science.1232808 |
0.483 |
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| 2013 |
Wang C, Jiang Y, Ma J, Wu H, Wacker D, Katritch V, Han GW, Liu W, Huang XP, Vardy E, McCorvy JD, Gao X, Zhou XE, Melcher K, Zhang C, ... ... Xu HE, et al. Structural basis for molecular recognition at serotonin receptors. Science (New York, N.Y.). 340: 610-4. PMID 23519210 DOI: 10.1126/Science.1232807 |
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| 2013 |
Ke J, Xu HE, Williams BO. Lipid modification in Wnt structure and function. Current Opinion in Lipidology. 24: 129-33. PMID 23348724 DOI: 10.1097/Mol.0B013E32835Df2Bf |
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| 2013 |
West GM, Pascal BD, Ng LM, Soon FF, Melcher K, Xu HE, Chalmers MJ, Griffin PR. Protein conformation ensembles monitored by HDX reveal a structural rationale for abscisic acid signaling protein affinities and activities. Structure (London, England : 1993). 21: 229-35. PMID 23290725 DOI: 10.1016/J.Str.2012.12.001 |
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| 2013 |
Joiner DM, Ke J, Zhong Z, Xu HE, Williams BO. LRP5 and LRP6 in development and disease. Trends in Endocrinology and Metabolism: Tem. 24: 31-9. PMID 23245947 DOI: 10.1016/J.Tem.2012.10.003 |
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| 2012 |
Martin KR, Narang P, Xu Y, Kauffman AL, Petit J, Xu HE, Meurice N, MacKeigan JP. Identification of small molecule inhibitors of PTPσ through an integrative virtual and biochemical approach. Plos One. 7: e50217. PMID 23185579 DOI: 10.1371/Journal.Pone.0050217 |
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| 2012 |
Soon FF, Suino-Powell KM, Li J, Yong EL, Xu HE, Melcher K. Abscisic acid signaling: thermal stability shift assays as tool to analyze hormone perception and signal transduction. Plos One. 7: e47857. PMID 23112859 DOI: 10.1371/Journal.Pone.0047857 |
0.365 |
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| 2012 |
Zhou XE, Soon FF, Ng LM, Kovach A, Suino-Powell KM, Li J, Yong EL, Zhu JK, Xu HE, Melcher K. Catalytic mechanism and kinase interactions of ABA-signaling PP2C phosphatases. Plant Signaling & Behavior. 7: 581-8. PMID 22516825 DOI: 10.4161/Psb.19694 |
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| 2012 |
Blind RD, Pineda-Torra I, Xu Y, Xu HE, Garabedian MJ. Ligand structural motifs can decouple glucocorticoid receptor transcriptional activation from target promoter occupancy. Biochemical and Biophysical Research Communications. 420: 839-44. PMID 22465009 DOI: 10.1016/J.Bbrc.2012.03.084 |
0.36 |
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| 2012 |
Ke J, Zhang C, Harikumar KG, Zylstra-Diegel CR, Wang L, Mowry LE, Miller LJ, Williams BO, Xu HE. Modulation of β-catenin signaling by glucagon receptor activation. Plos One. 7: e33676. PMID 22438981 DOI: 10.1371/Journal.Pone.0033676 |
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| 2012 |
Xu HE, Xiao R. A new era for GPCR research: structures, biology and drug discovery. Acta Pharmacologica Sinica. 33: 289-290. PMID 22388110 DOI: 10.1038/Aps.2012.16 |
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| 2012 |
Tiong CT, Chen C, Zhang SJ, Li J, Soshilov A, Denison MS, Lee LS, Tam VH, Wong SP, Xu HE, Yong EL. A novel prenylflavone restricts breast cancer cell growth through AhR-mediated destabilization of ERα protein. Carcinogenesis. 33: 1089-97. PMID 22345291 DOI: 10.1093/Carcin/Bgs110 |
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| 2012 |
Zhou XE, Melcher K, Xu HE. Structure and activation of rhodopsin. Acta Pharmacologica Sinica. 33: 291-299. PMID 22266727 DOI: 10.1038/Aps.2011.171 |
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| 2012 |
Pal K, Melcher K, Xu HE. Structure and mechanism for recognition of peptide hormones by Class B G-protein-coupled receptors. Acta Pharmacologica Sinica. 33: 300-11. PMID 22266723 DOI: 10.1038/Aps.2011.170 |
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| 2012 |
Yu S, Xu HE. Couple Dynamics: PPARγ and Its Ligand Partners Structure. 20: 2-4. PMID 22244751 DOI: 10.1016/J.Str.2011.12.002 |
0.42 |
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| 2012 |
Zhi X, Zhou XE, Melcher K, Motola DL, Gelmedin V, Hawdon J, Kliewer SA, Mangelsdorf DJ, Xu HE. Structural conservation of ligand binding reveals a bile acid-like signaling pathway in nematodes Journal of Biological Chemistry. 287: 4894-4903. PMID 22170062 DOI: 10.1074/Jbc.M111.315242 |
0.406 |
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| 2012 |
Soon FF, Ng LM, Zhou XE, West GM, Kovach A, Tan MH, Suino-Powell KM, He Y, Xu Y, Chalmers MJ, Brunzelle JS, Zhang H, Yang H, Jiang H, Li J, ... ... Xu HE, et al. Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases. Science (New York, N.Y.). 335: 85-8. PMID 22116026 DOI: 10.1126/Science.1215106 |
0.414 |
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| 2012 |
Malapaka RR, Khoo S, Zhang J, Choi JH, Zhou XE, Xu Y, Gong Y, Li J, Yong EL, Chalmers MJ, Chang L, Resau JH, Griffin PR, Chen YE, Xu HE. Identification and mechanism of 10-carbon fatty acid as modulating ligand of peroxisome proliferator-activated receptors. The Journal of Biological Chemistry. 287: 183-95. PMID 22039047 DOI: 10.1074/Jbc.M111.294785 |
0.378 |
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| 2011 |
He Y, Xu Y, Zhang C, Gao X, Dykema KJ, Martin KR, Ke J, Hudson EA, Khoo SK, Resau JH, Alberts AS, MacKeigan JP, Furge KA, Xu HE. Identification of a lysosomal pathway that modulates glucocorticoid signaling and the inflammatory response. Science Signaling. 4: ra44. PMID 21730326 DOI: 10.1126/Scisignal.2001450 |
0.372 |
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| 2011 |
Kumar S, Pioszak A, Zhang C, Swaminathan K, Xu HE. Crystal structure of the PAC1R extracellular domain unifies a consensus fold for hormone recognition by class B G-protein coupled receptors. Plos One. 6: e19682. PMID 21625560 DOI: 10.1371/Journal.Pone.0019682 |
0.491 |
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| 2011 |
Miao J, Choi SE, Seok SM, Yang L, Zuercher WJ, Xu Y, Willson TM, Xu HE, Kemper JK. Ligand-dependent regulation of the activity of the orphan nuclear receptor, small heterodimer partner (SHP), in the repression of bile acid biosynthetic CYP7A1 and CYP8B1 genes. Molecular Endocrinology (Baltimore, Md.). 25: 1159-69. PMID 21566081 DOI: 10.1210/Me.2011-0033 |
0.416 |
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| 2011 |
Zhou XE, Suino-Powell KM, Xu Y, Chan CW, Tanabe O, Kruse SW, Reynolds R, Engel JD, Xu HE. The orphan nuclear receptor TR4 is a vitamin A-activated nuclear receptor. The Journal of Biological Chemistry. 286: 2877-85. PMID 21068381 DOI: 10.1074/Jbc.M110.168740 |
0.485 |
|
| 2010 |
Pal K, Swaminathan K, Xu HE, Pioszak AA. Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor. The Journal of Biological Chemistry. 285: 40351-61. PMID 20966082 DOI: 10.1074/Jbc.M110.186072 |
0.439 |
|
| 2010 |
Melcher K, Zhou XE, Xu HE. Thirsty plants and beyond: structural mechanisms of abscisic acid perception and signaling Current Opinion in Structural Biology. 20: 722-729. PMID 20951573 DOI: 10.1016/J.Sbi.2010.09.007 |
0.432 |
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| 2010 |
Melcher K, Xu Y, Ng LM, Zhou XE, Soon FF, Chinnusamy V, Suino-Powell KM, Kovach A, Tham FS, Cutler SR, Li J, Yong EL, Zhu JK, Xu HE. Identification and mechanism of ABA receptor antagonism. Nature Structural & Molecular Biology. 17: 1102-8. PMID 20729862 DOI: 10.1038/Nsmb.1887 |
0.46 |
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| 2010 |
Tolbert WD, Daugherty-Holtrop J, Gherardi E, Vande Woude G, Xu HE. Structural basis for agonism and antagonism of hepatocyte growth factor. Proceedings of the National Academy of Sciences of the United States of America. 107: 13264-9. PMID 20624990 DOI: 10.1073/Pnas.1005183107 |
0.377 |
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| 2010 |
Pioszak AA, Harikumar KG, Parker NR, Miller LJ, Xu HE. Dimeric arrangement of the parathyroid hormone receptor and a structural mechanism for ligand-induced dissociation. The Journal of Biological Chemistry. 285: 12435-44. PMID 20172855 DOI: 10.1074/Jbc.M109.093138 |
0.524 |
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| 2010 |
Schopfer FJ, Cole MP, Groeger AL, Chen CS, Khoo NK, Woodcock SR, Golin-Bisello F, Motanya UN, Li Y, Zhang J, Garcia-Barrio MT, Rudolph TK, Rudolph V, Bonacci G, Baker PR, ... Xu HE, et al. Covalent peroxisome proliferator-activated receptor gamma adduction by nitro-fatty acids: selective ligand activity and anti-diabetic signaling actions. The Journal of Biological Chemistry. 285: 12321-33. PMID 20097754 DOI: 10.1074/Jbc.M109.091512 |
0.398 |
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| 2010 |
Zhou XE, Suino-Powell KM, Li J, He Y, Mackeigan JP, Melcher K, Yong EL, Xu HE. Identification of SRC3/AIB1 as a preferred coactivator for hormone-activated androgen receptor. The Journal of Biological Chemistry. 285: 9161-71. PMID 20086010 DOI: 10.1074/Jbc.M109.085779 |
0.351 |
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| 2010 |
Zhou XE, Suino-Powell K, Ludidi PL, McDonnell DP, Xu HE. Expression, purification and primary crystallographic study of human androgen receptor in complex with DNA and coactivator motifs. Protein Expression and Purification. 71: 21-7. PMID 19995608 DOI: 10.1016/J.Pep.2009.12.002 |
0.378 |
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| 2009 |
Melcher K, Ng LM, Zhou XE, Soon FF, Xu Y, Suino-Powell KM, Park SY, Weiner JJ, Fujii H, Chinnusamy V, Kovach A, Li J, Wang Y, Li J, Peterson FC, ... ... Xu HE, et al. A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors. Nature. 462: 602-8. PMID 19898420 DOI: 10.1038/Nature08613 |
0.487 |
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| 2009 |
Pioszak AA, Parker NR, Gardella TJ, Xu HE. Structural basis for parathyroid hormone-related protein binding to the parathyroid hormone receptor and design of conformation-selective peptides. The Journal of Biological Chemistry. 284: 28382-91. PMID 19674967 DOI: 10.1074/Jbc.M109.022905 |
0.454 |
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| 2009 |
Chakravarthy MV, Lodhi IJ, Yin L, Malapaka RR, Xu HE, Turk J, Semenkovich CF. Identification of a physiologically relevant endogenous ligand for PPARalpha in liver. Cell. 138: 476-88. PMID 19646743 DOI: 10.1016/J.Cell.2009.05.036 |
0.384 |
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| 2009 |
Wang Z, Zhou XE, Motola DL, Gao X, Suino-Powell K, Conneely A, Ogata C, Sharma KK, Auchus RJ, Lok JB, Hawdon JM, Kliewer SA, Xu HE, Mangelsdorf DJ. Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes. Proceedings of the National Academy of Sciences of the United States of America. 106: 9138-43. PMID 19497877 DOI: 10.1073/Pnas.0904064106 |
0.392 |
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| 2008 |
Xu HE, Li Y. Ligand-Dependent and -Independent Regulation of PPARγ and Orphan Nuclear Receptors Science Signaling. 1. PMID 19050303 DOI: 10.1126/Scisignal.148Pe52 |
0.455 |
|
| 2008 |
Pioszak AA, Parker NR, Suino-Powell K, Xu HE. Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1. The Journal of Biological Chemistry. 283: 32900-12. PMID 18801728 DOI: 10.1074/Jbc.M805749200 |
0.47 |
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| 2008 |
Kruse SW, Suino-Powell K, Zhou XE, Kretschman JE, Reynolds R, Vonrhein C, Xu Y, Wang L, Tsai SY, Tsai MJ, Xu HE. Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor. Plos Biology. 6: e227. PMID 18798693 DOI: 10.1371/Journal.Pbio.0060227 |
0.483 |
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| 2008 |
Li Y, Zhang J, Schopfer FJ, Martynowski D, Garcia-Barrio MT, Kovach A, Suino-Powell K, Baker PRS, Freeman BA, Chen YE, Xu HE. Molecular recognition of nitrated fatty acids by PPARγ Nature Structural and Molecular Biology. 15: 865-867. PMID 18604218 DOI: 10.1038/Nsmb.1447 |
0.392 |
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| 2008 |
Tao YG, Xu Y, Xu HE, Simons SS. Mutations of glucocorticoid receptor differentially affect AF2 domain activity in a steroid-selective manner to alter the potency and efficacy of gene induction and repression Biochemistry. 47: 7648-7662. PMID 18578507 DOI: 10.1021/Bi800472W |
0.442 |
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| 2008 |
Pioszak AA, Xu HE. Molecular recognition of parathyroid hormone by its G protein-coupled receptor. Proceedings of the National Academy of Sciences of the United States of America. 105: 5034-9. PMID 18375760 DOI: 10.1073/Pnas.0801027105 |
0.491 |
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| 2008 |
Suino-Powell K, Xu Y, Zhang C, Tao YG, Tolbert WD, Simons SS, Xu HE. Doubling the size of the glucocorticoid receptor ligand binding pocket by deacylcortivazol Molecular and Cellular Biology. 28: 1915-1923. PMID 18160712 DOI: 10.1128/Mcb.01541-07 |
0.459 |
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| 2007 |
Guo D, Sarkar J, Suino-Powell K, Xu Y, Matsumoto K, Jia Y, Yu S, Khare S, Haldar K, Rao MS, Foreman JE, Monga SP, Peters JM, Xu HE, Reddy JK. Induction of nuclear translocation of constitutive androstane receptor by peroxisome proliferator-activated receptor alpha synthetic ligands in mouse liver. The Journal of Biological Chemistry. 282: 36766-76. PMID 17962186 DOI: 10.1074/Jbc.M707183200 |
0.431 |
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| 2007 |
Tolbert WD, Daugherty J, Gao C, Xie Q, Miranti C, Gherardi E, Vande Woude G, Xu HE. A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist. Proceedings of the National Academy of Sciences of the United States of America. 104: 14592-7. PMID 17804794 DOI: 10.1073/Pnas.0704290104 |
0.438 |
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| 2007 |
Sierra ML, Beneton V, Boullay AB, Boyer T, Brewster AG, Donche F, Forest MC, Fouchet MH, Gellibert FJ, Grillot DA, Lambert MH, Laroze A, Le Grumelec C, Linget JM, Montana VG, ... ... Xu HE, et al. Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. Journal of Medicinal Chemistry. 50: 685-95. PMID 17243659 DOI: 10.1021/Jm058056X |
0.33 |
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| 2006 |
Motola DL, Cummins CL, Rottiers V, Sharma KK, Li T, Li Y, Suino-Powell K, Xu HE, Auchus RJ, Antebi A, Mangelsdorf DJ. Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans. Cell. 124: 1209-23. PMID 16529801 DOI: 10.1016/J.Cell.2006.01.037 |
0.398 |
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| 2005 |
Li Y, Suino K, Daugherty J, Xu HE. Structural and biochemical mechanisms for the specificity of hormone binding and coactivator assembly by mineralocorticoid receptor Molecular Cell. 19: 367-380. PMID 16061183 DOI: 10.1016/J.Molcel.2005.06.026 |
0.461 |
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| 2005 |
Li Y, Choi M, Suino K, Kovach A, Daugherty J, Kliewer SA, Xu HE. Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner. Proceedings of the National Academy of Sciences of the United States of America. 102: 9505-10. PMID 15976031 DOI: 10.1073/Pnas.0501204102 |
0.488 |
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| 2005 |
Li Y, Choi M, Cavey G, Daugherty J, Suino K, Kovach A, Bingham NC, Kliewer SA, Xu HE. Crystallographic identification and functional characterization of phospholipids as ligands for the orphan nuclear receptor steroidogenic factor-1. Molecular Cell. 17: 491-502. PMID 15721253 DOI: 10.1016/J.Molcel.2005.02.002 |
0.471 |
|
| 2004 |
Suino K, Peng L, Reynolds R, Li Y, Cha JY, Repa JJ, Kliewer SA, Xu HE. The Nuclear Xenobiotic Receptor CAR: Structural Determinants of Constitutive Activation and Heterodimerization Molecular Cell. 16: 893-905. PMID 15610733 DOI: 10.1016/J.Molcel.2004.11.036 |
0.487 |
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| 2004 |
Haffner CD, Lenhard JM, Miller AB, McDougald DL, Dwornik K, Ittoop OR, Gampe RT, Xu HE, Blanchard S, Montana VG, Consler TG, Bledsoe RK, Ayscue A, Croom D. Structure-based design of potent retinoid X receptor alpha agonists. Journal of Medicinal Chemistry. 47: 2010-29. PMID 15056000 DOI: 10.1021/Jm030565G |
0.319 |
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| 2004 |
Agostini M, Gurnell M, Savage DB, Wood EM, Smith AG, Rajanayagam O, Garnes KT, Levinson SH, Xu HE, Schwabe JW, Willson TM, O'Rahilly S, Chatterjee VK. Tyrosine agonists reverse the molecular defects associated with dominant-negative mutations in human peroxisome proliferator-activated receptor gamma. Endocrinology. 145: 1527-38. PMID 14657011 DOI: 10.1210/En.2003-1271 |
0.437 |
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| 2003 |
Stanley TB, Leesnitzer LM, Montana VG, Galardi CM, Lambert MH, Holt JA, Xu HE, Moore LB, Blanchard SG, Stimmel JB. Subtype specific effects of peroxisome proliferator-activated receptor ligands on corepressor affinity. Biochemistry. 42: 9278-87. PMID 12899614 DOI: 10.1021/Bi034472C |
0.437 |
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| 2003 |
Li Y, Lambert MH, Xu HE. Activation of nuclear receptors: A perspective from structural genomics Structure. 11: 741-746. PMID 12842037 DOI: 10.1016/S0969-2126(03)00133-3 |
0.505 |
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| 2003 |
Sznaidman ML, Haffner CD, Maloney PR, Fivush A, Chao E, Goreham D, Sierra ML, LeGrumelec C, Xu HE, Montana VG, Lambert MH, Willson TM, Oliver WR, Sternbach DD. Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity. Bioorganic & Medicinal Chemistry Letters. 13: 1517-21. PMID 12699745 DOI: 10.1016/S0960-894X(03)00207-5 |
0.39 |
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| 2003 |
Xu HE, Lambert MH. Structural Mechanisms of Ligand-Mediated Signaling by Nuclear Receptors Handbook of Cell Signaling. 3: 21-24. DOI: 10.1016/B978-012124546-7/50634-3 |
0.347 |
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| 2002 |
Bledsoe RK, Montana VG, Stanley TB, Delves CJ, Apolito CJ, McKee DD, Consler TG, Parks DJ, Stewart EL, Willson TM, Lambert MH, Moore JT, Pearce KH, Xu HE. Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition. Cell. 110: 93-105. PMID 12151000 DOI: 10.1016/S0092-8674(02)00817-6 |
0.516 |
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| 2002 |
Ghosh JC, Yang X, Zhang A, Lambert MH, Li H, Xu HE, Chen JD. Interactions that determine the assembly of a retinoid X receptor/corepressor complex Proceedings of the National Academy of Sciences of the United States of America. 99: 5842-5847. PMID 11972046 DOI: 10.1073/Pnas.092043399 |
0.458 |
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| 2002 |
Xu HE, Stanley TB, Montana VG, Lambert MH, Shearer BG, Cobb JE, McKee DD, Galardi CM, Plunket KD, Nolte RT, Parks DJ, Moore JT, Kliewer SA, Willson TM, Stimmel JB. Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha. Nature. 415: 813-7. PMID 11845213 DOI: 10.1038/415813A |
0.498 |
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| 2001 |
Xu HE, Lambert MH, Montana VG, Plunket KD, Moore LB, Collins JL, Oplinger JA, Kliewer SA, Gampe RT, McKee DD, Moore JT, Willson TM. Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors. Proceedings of the National Academy of Sciences of the United States of America. 98: 13919-24. PMID 11698662 DOI: 10.1073/pnas.241410198 |
0.353 |
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| 2001 |
Oliver WR, Shenk JL, Snaith MR, Russell CS, Plunket KD, Bodkin NL, Lewis MC, Winegar DA, Sznaidman ML, Lambert MH, Xu HE, Sternbach DD, Kliewer SA, Hansen BC, Willson TM. A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport. Proceedings of the National Academy of Sciences of the United States of America. 98: 5306-11. PMID 11309497 DOI: 10.1073/Pnas.091021198 |
0.336 |
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| 2001 |
Kliewer SA, Xu HE, Lambert MH, Willson TM. Peroxisome proliferator-activated receptors: From genes to physiology Recent Progress in Hormone Research. 56: 239-263. PMID 11237216 DOI: 10.1210/Rp.56.1.239 |
0.44 |
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| 2001 |
Melcher K, Xu HE. Gal80–Gal80 interaction on adjacent Gal4p binding sites is required for complete GAL gene repression The Embo Journal. 20: 841-851. PMID 11179228 DOI: 10.1093/Emboj/20.4.841 |
0.324 |
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| 2000 |
Gampe R.T. J, Montana VG, Lambert MH, Wisely GB, Milburn MV, Xu HE. Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix Genes and Development. 14: 2229-2241. PMID 10970886 DOI: 10.1101/gad.802300 |
0.391 |
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| 2000 |
Gampe RT, Montana VG, Lambert MH, Miller AB, Bledsoe RK, Milburn MV, Kliewer SA, Willson TM, Xu HE. Asymmetry in the PPARγ/RXRα crystal structure reveals the molecular basis of heterodimerization among nuclear receptors Molecular Cell. 5: 545-555. PMID 10882139 DOI: 10.1016/S1097-2765(00)80448-7 |
0.467 |
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| 2000 |
Takada I, Yu RT, Xu HE, Lambert MH, Montana VG, Kliewer SA, Evans RM, Umesono K. Alteration of a single amino acid in peroxisome proliferator-activated receptor-alpha (PPAR alpha) generates a PPAR delta phenotype. Molecular Endocrinology (Baltimore, Md.). 14: 733-40. PMID 10809235 DOI: 10.1210/Mend.14.5.0456 |
0.369 |
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| 1999 |
Xu HE, Rould MA, Xu W, Epstein JA, Maas RL, Pabo CO. Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding. Genes & Development. 13: 1263-75. PMID 10346815 DOI: 10.1101/Gad.13.10.1263 |
0.592 |
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| 1999 |
Xu HE, Lambert MH, Montana VG, Parks DJ, Blanchard SG, Brown PJ, Sternbach DD, Lehmann JM, Wisely GB, Willson TM, Kliewer SA, Milburn MV. Molecular recognition of fatty acids by peroxisome proliferator- activated receptors Molecular Cell. 3: 397-403. PMID 10198642 DOI: 10.1016/S1097-2765(00)80467-0 |
0.426 |
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| 1997 |
Zheng WJ, Xu HE, Johnston SA. The cysteine-peptidase bleomycin hydrolase is a member of the galactose regulon in yeast. Journal of Biological Chemistry. 272: 30350-30355. PMID 9374524 DOI: 10.1074/Jbc.272.48.30350 |
0.322 |
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