| Year |
Citation |
Score |
| 2023 |
Mann JE, Lucca L, Austin MR, Merkin RD, Robert ME, Al Bawardy B, Raddassi K, Aizenbud L, Joshi NS, Hafler DA, Abraham C, Herold KC, Kluger HM. ScRNA-seq defines dynamic T-cell subsets in longitudinal colon and peripheral blood samples in immune checkpoint inhibitor-induced colitis. Journal For Immunotherapy of Cancer. 11. PMID 37586769 DOI: 10.1136/jitc-2023-007358 |
0.321 |
|
| 2023 |
Shinoda K, Li R, Rezk A, Mexhitaj I, Patterson KR, Kakara M, Zuroff L, Bennett JL, von Büdingen HC, Carruthers R, Edwards KR, Fallis R, Giacomini PS, Greenberg BM, Hafler DA, et al. Differential effects of anti-CD20 therapy on CD4 and CD8 T cells and implication of CD20-expressing CD8 T cells in MS disease activity. Proceedings of the National Academy of Sciences of the United States of America. 120: e2207291120. PMID 36634138 DOI: 10.1073/pnas.2207291120 |
0.359 |
|
| 2022 |
Asashima H, Mohanty S, Comi M, Ruff WE, Hoehn KB, Wong P, Klein J, Lucas C, Cohen I, Coffey S, Lele N, Greta L, Raddassi K, Chaudhary O, Unterman A, ... ... Hafler DA, et al. PD-1CXCR5CD4 peripheral helper T cells promote CXCR3 plasmablasts in human acute viral infection. Cell Reports. 111895. PMID 36596303 DOI: 10.1016/j.celrep.2022.111895 |
0.312 |
|
| 2022 |
Axisa PP, Yoshida TM, Lucca LE, Kasler HG, Lincoln MR, Pham GH, Del Priore D, Carpier JM, Lucas CL, Verdin E, Sumida TS, Hafler DA. A multiple sclerosis-protective coding variant reveals an essential role for HDAC7 in regulatory T cells. Science Translational Medicine. 14: eabl3651. PMID 36516268 DOI: 10.1126/scitranslmed.abl3651 |
0.385 |
|
| 2022 |
Asashima H, Axisa PP, Pham THG, Longbrake EE, Ruff WE, Lele N, Cohen I, Raddassi K, Sumida TS, Hafler DA. Impaired TIGIT expression on B cells drives circulating follicular helper T cell expansion in multiple sclerosis. The Journal of Clinical Investigation. 132. PMID 36250467 DOI: 10.1172/JCI156254 |
0.365 |
|
| 2022 |
Pompura SL, Hafler DA, Dominguez-Villar M. Fatty Acid Metabolism and T Cells in Multiple Sclerosis. Frontiers in Immunology. 13: 869197. PMID 35603182 DOI: 10.3389/fimmu.2022.869197 |
0.327 |
|
| 2022 |
Pauken KE, Lagattuta KA, Lu BY, Lucca LE, Daud AI, Hafler DA, Kluger HM, Raychaudhuri S, Sharpe AH. TCR-sequencing in cancer and autoimmunity: barcodes and beyond. Trends in Immunology. PMID 35090787 DOI: 10.1016/j.it.2022.01.002 |
0.303 |
|
| 2022 |
Unterman A, Sumida TS, Nouri N, Yan X, Zhao AY, Gasque V, Schupp JC, Asashima H, Liu Y, Cosme C, Deng W, Chen M, Raredon MSB, Hoehn KB, Wang G, ... ... Hafler DA, et al. Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19. Nature Communications. 13: 440. PMID 35064122 DOI: 10.1038/s41467-021-27716-4 |
0.326 |
|
| 2020 |
Pappalardo JL, Zhang L, Pecsok MK, Perlman K, Zografou C, Raddassi K, Abulaban A, Krishnaswamy S, Antel J, van Dijk D, Hafler DA. Transcriptomic and clonal characterization of T cells in the human central nervous system. Science Immunology. 5. PMID 32948672 DOI: 10.1126/Sciimmunol.Abb8786 |
0.502 |
|
| 2020 |
Choileáin SN, Kleinewietfeld M, Raddassi K, Hafler DA, Ruff WE, Longbrake EE. CXCR3+ T cells in multiple sclerosis correlate with reduced diversity of the gut microbiome. Journal of Translational Autoimmunity. 3: 100032. PMID 32743517 DOI: 10.1016/j.jtauto.2019.100032 |
0.435 |
|
| 2020 |
Lucca LE, Lerner BA, Park C, DeBartolo D, Harnett B, Kumar VP, Ponath G, Raddassi K, Huttner A, Hafler DA, Pitt D. Differential expression of the T-cell inhibitor TIGIT in glioblastoma and MS. Neurology(R) Neuroimmunology & Neuroinflammation. 7. PMID 32269065 DOI: 10.1212/Nxi.0000000000000712 |
0.482 |
|
| 2019 |
Longbrake EE, Hafler DA. Siponimod Chips Away at Progressive MS. Cell. 179: 1440. PMID 31951523 DOI: 10.1016/J.Cell.2019.11.034 |
0.368 |
|
| 2019 |
Sumida T, Lincoln MR, Ukeje CM, Rodriguez DM, Akazawa H, Noda T, Naito AT, Komuro I, Dominguez-Villar M, Hafler DA. Author Correction: Activated β-catenin in Foxp3 regulatory T cells links inflammatory environments to autoimmunity. Nature Immunology. PMID 31175348 DOI: 10.1038/S41590-019-0438-6 |
0.35 |
|
| 2019 |
Dominguez-Villar M, Raddassi K, Danielsen AC, Guarnaccia J, Hafler DA. Corrigendum to "Fingolimod modulates T cell phenotype and regulatory T cell plasticity in vivo" [Yjaut 96C (2019) 40-49]. Journal of Autoimmunity. PMID 31109655 DOI: 10.1016/J.Jaut.2019.05.008 |
0.42 |
|
| 2019 |
James JA, Chen H, Young KA, Bemis EA, Seifert J, Bourn RL, Deane KD, Demoruelle MK, Feser M, O'Dell JR, Weisman MH, Keating RM, Gaffney PM, Kelly JA, Langefeld CD, ... ... Hafler DA, et al. Latent autoimmunity across disease-specific boundaries in at-risk first-degree relatives of SLE and RA patients. Ebiomedicine. PMID 30952617 DOI: 10.1016/J.Ebiom.2019.03.063 |
0.305 |
|
| 2019 |
Stathopoulos P, Chastre A, Waters P, Irani S, Fichtner ML, Benotti ES, Guthridge JM, Seifert J, Nowak RJ, Buckner JH, Holers VM, James JA, Hafler DA, O'Connor KC. Autoantibodies against Neurologic Antigens in Nonneurologic Autoimmunity. Journal of Immunology (Baltimore, Md. : 1950). PMID 30824481 DOI: 10.4049/Jimmunol.1801295 |
0.38 |
|
| 2019 |
Pappalardo JL, Hafler DA. Multiple sclerosis enters a grey area. Nature. 566: 465-466. PMID 30809050 DOI: 10.1038/D41586-019-00563-6 |
0.372 |
|
| 2019 |
Lucca LE, Axisa PP, Singer ER, Nolan NM, Dominguez-Villar M, Hafler DA. TIGIT signaling restores suppressor function of Th1 Tregs. Jci Insight. 4. PMID 30728325 DOI: 10.1172/Jci.Insight.124427 |
0.39 |
|
| 2018 |
Ponath G, Lincoln MR, Levine-Ritterman M, Park C, Dahlawi S, Mubarak M, Sumida T, Airas L, Zhang S, Isitan C, Nguyen TD, Raine CS, Hafler DA, Pitt D. Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis. Nature Communications. 9: 5337. PMID 30559390 DOI: 10.1038/S41467-018-07785-8 |
0.39 |
|
| 2018 |
Sumida T, Lincoln MR, Ukeje CM, Rodriguez DM, Akazawa H, Noda T, Naito AT, Komuro I, Dominguez-Villar M, Hafler DA. Activated β-catenin in Foxp3 regulatory T cells links inflammatory environments to autoimmunity. Nature Immunology. PMID 30374130 DOI: 10.1038/S41590-018-0236-6 |
0.431 |
|
| 2018 |
Farhadian SF, Mehta SS, Zografou C, Robertson K, Price RW, Pappalardo J, Chiarella J, Hafler DA, Spudich SS. Single-cell RNA sequencing reveals microglia-like cells in cerebrospinal fluid during virologically suppressed HIV. Jci Insight. 3. PMID 30232286 DOI: 10.1172/Jci.Insight.121718 |
0.307 |
|
| 2018 |
Dominguez-Villar M, Raddassi K, Danielsen AC, Guarnaccia J, Hafler DA. Fingolimod modulates T cell phenotype and regulatory T cell plasticity in vivo. Journal of Autoimmunity. PMID 30122421 DOI: 10.1016/J.Jaut.2018.08.002 |
0.502 |
|
| 2018 |
Murray C, Miwa H, Dhar M, Park DE, Pao E, Martinez J, Kaanumale S, Loghin E, Graf J, Rhaddassi K, Kwok WW, Hafler D, Puleo C, Di Carlo D. Unsupervised capture and profiling of rare immune cells using multi-directional magnetic ratcheting. Lab On a Chip. PMID 30039125 DOI: 10.1039/C8Lc00518D |
0.356 |
|
| 2018 |
Dominguez-Villar M, Hafler DA. Regulatory T cells in autoimmune disease. Nature Immunology. PMID 29925983 DOI: 10.1038/S41590-018-0120-4 |
0.466 |
|
| 2018 |
Kitz A, Singer E, Hafler D. Regulatory T Cells: From Discovery to Autoimmunity. Cold Spring Harbor Perspectives in Medicine. 8. PMID 29311129 DOI: 10.1101/Cshperspect.A029041 |
0.506 |
|
| 2017 |
Fuchs A, Gliwiński M, Grageda N, Spiering R, Abbas AK, Appel S, Bacchetta R, Battaglia M, Berglund D, Blazar B, Bluestone JA, Bornhäuser M, Ten Brinke A, Brusko TM, Cools N, ... ... Hafler DA, et al. Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization. Frontiers in Immunology. 8: 1844. PMID 29379498 DOI: 10.3389/Fimmu.2017.01844 |
0.408 |
|
| 2017 |
Goods BA, Hernandez AL, Lowther DE, Lucca LE, Lerner BA, Gunel M, Raddassi K, Coric V, Hafler DA, Love JC. Functional differences between PD-1+ and PD-1- CD4+ effector T cells in healthy donors and patients with glioblastoma multiforme. Plos One. 12: e0181538. PMID 28880903 DOI: 10.1371/Journal.Pone.0181538 |
0.307 |
|
| 2017 |
Nylander AN, Ponath GD, Axisa PP, Mubarak M, Tomayko M, Kuchroo VK, Pitt D, Hafler DA. Podoplanin is a negative regulator of Th17 inflammation. Jci Insight. 2. PMID 28878118 DOI: 10.1172/Jci.Insight.92321 |
0.403 |
|
| 2017 |
Lucca LE, Hafler DA. Resisting fatal attraction: a glioma oncometabolite prevents CD8+ T cell recruitment. The Journal of Clinical Investigation. PMID 28319049 DOI: 10.1172/Jci93565 |
0.346 |
|
| 2017 |
Lucca LE, Hafler DA. Co-inhibitory blockade while preserving tolerance: checkpoint inhibitors for glioblastoma. Immunological Reviews. 276: 9-25. PMID 28258696 DOI: 10.1111/Imr.12529 |
0.307 |
|
| 2016 |
Kitz A, de Marcken M, Gautron AS, Mitrovic M, Hafler DA, Dominguez-Villar M. AKT isoforms modulate Th1-like Treg generation and function in human autoimmune disease. Embo Reports. PMID 27312110 DOI: 10.15252/Embr.201541905 |
0.42 |
|
| 2016 |
Arterbery AS, Osafo-Addo A, Avitzur Y, Ciarleglio M, Deng Y, Lobritto SJ, Martinez M, Hafler DA, Kleinewietfeld M, Ekong UD. Production of Proinflammatory Cytokines by Monocytes in Liver-Transplanted Recipients with De Novo Autoimmune Hepatitis Is Enhanced and Induces TH1-like Regulatory T Cells. Journal of Immunology (Baltimore, Md. : 1950). 196: 4040-51. PMID 27183637 DOI: 10.4049/Jimmunol.1502276 |
0.351 |
|
| 2016 |
Lowther DE, Goods BA, Lucca LE, Lerner BA, Raddassi K, van Dijk D, Hernandez AL, Duan X, Gunel M, Coric V, Krishnaswamy S, Love JC, Hafler DA. PD-1 marks dysfunctional regulatory T cells in malignant gliomas. Jci Insight. 1. PMID 27182555 DOI: 10.1172/Jci.Insight.85935 |
0.334 |
|
| 2016 |
Chastre A, Hafler DA, O'Connor KC. Evaluation of KIR4.1 as an Immune Target in Multiple Sclerosis. The New England Journal of Medicine. 374: 1495-1496. PMID 27074083 DOI: 10.1056/Nejmc1513302 |
0.337 |
|
| 2016 |
Keshavan A, Paul F, Beyer MK, Zhu AH, Papinutto N, Shinohara RT, Stern W, Amann M, Bakshi R, Bischof A, Carriero A, Comabella M, Crane JC, D'Alfonso S, Demaerel P, ... ... Hafler DA, et al. Power Estimation for Non-Standardized Multisite Studies. Neuroimage. PMID 27039700 DOI: 10.1016/J.Neuroimage.2016.03.051 |
0.486 |
|
| 2016 |
Cao Y, Nylander A, Ramanan S, Goods BA, Ponath G, Zabad R, Chiang VL, Vortmeyer AO, Hafler DA, Pitt D. CNS demyelination and enhanced myelin-reactive responses after ipilimumab treatment. Neurology. PMID 26984943 DOI: 10.1212/Wnl.0000000000002594 |
0.472 |
|
| 2016 |
Kofler DM, Farkas A, von Bergwelt-Baildon M, Hafler DA. The Link between CD6 and Autoimmunity: Genetic and Cellular Associations. Current Drug Targets. PMID 26844569 DOI: 10.2174/1389450117666160201105934 |
0.425 |
|
| 2015 |
Willis SN, Stathopoulos P, Chastre A, Compton SD, Hafler DA, O'Connor KC. Investigating the Antigen Specificity of Multiple Sclerosis Central Nervous System-Derived Immunoglobulins. Frontiers in Immunology. 6: 600. PMID 26648933 DOI: 10.3389/Fimmu.2015.00600 |
0.441 |
|
| 2015 |
Hernandez AL, Kitz A, Wu C, Lowther DE, Rodriguez DM, Vudattu N, Deng S, Herold KC, Kuchroo VK, Kleinewietfeld M, Hafler DA. Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells. The Journal of Clinical Investigation. 125: 4212-22. PMID 26524592 DOI: 10.1172/Jci81151 |
0.408 |
|
| 2015 |
Housley WJ, Pitt D, Hafler DA. Biomarkers in multiple sclerosis. Clinical Immunology (Orlando, Fla.). 161: 51-8. PMID 26143623 DOI: 10.1016/J.Clim.2015.06.015 |
0.4 |
|
| 2015 |
Housley WJ, Fernandez SD, Vera K, Murikinati SR, Grutzendler J, Cuerdon N, Glick L, De Jager PL, Mitrovic M, Cotsapas C, Hafler DA. Genetic variants associated with autoimmunity drive NFκB signaling and responses to inflammatory stimuli. Science Translational Medicine. 7: 291ra93. PMID 26062845 DOI: 10.1126/Scitranslmed.Aaa9223 |
0.383 |
|
| 2015 |
Marson A, Housley WJ, Hafler DA. Genetic basis of autoimmunity. The Journal of Clinical Investigation. 125: 2234-41. PMID 26030227 DOI: 10.1172/Jci78086 |
0.345 |
|
| 2015 |
Hafler DA, Astier AL. Editorial: T cell regulation by the environment. Frontiers in Immunology. 6: 229. PMID 26029214 DOI: 10.3389/Fimmu.2015.00229 |
0.461 |
|
| 2015 |
Kitz A, Hafler DA. Thymic selection: to thine own self be true. Immunity. 42: 788-9. PMID 25992854 DOI: 10.1016/J.Immuni.2015.05.007 |
0.383 |
|
| 2015 |
Cao Y, Goods BA, Raddassi K, Nepom GT, Kwok WW, Love JC, Hafler DA. Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis. Science Translational Medicine. 7: 287ra74. PMID 25972006 DOI: 10.1126/Scitranslmed.Aaa8038 |
0.536 |
|
| 2015 |
Ransohoff RM, Hafler DA, Lucchinetti CF. Multiple sclerosis-a quiet revolution. Nature Reviews. Neurology. 11: 134-42. PMID 25686758 DOI: 10.1038/Nrneurol.2015.14 |
0.372 |
|
| 2015 |
Dominguez-Villar M, Gautron AS, de Marcken M, Keller MJ, Hafler DA. TLR7 induces anergy in human CD4(+) T cells. Nature Immunology. 16: 118-28. PMID 25401424 DOI: 10.1038/Ni.3036 |
0.404 |
|
| 2015 |
Farh KK, Marson A, Zhu J, Kleinewietfeld M, Housley WJ, Beik S, Shoresh N, Whitton H, Ryan RJ, Shishkin AA, Hatan M, Carrasco-Alfonso MJ, Mayer D, Luckey CJ, Patsopoulos NA, ... ... Hafler DA, et al. Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature. 518: 337-43. PMID 25363779 DOI: 10.1038/Nature13835 |
0.405 |
|
| 2015 |
Lowther DE, Weinhold K, Reap E, Vlahovic G, Omuro A, Sahebjam S, Baehring J, Voloschin A, Cloughesy T, Lim M, Coric V, Latek R, Simon J, Lerner B, Raddassi K, ... Hafler DA, et al. CBM-06IMMUNE BIOMARKER RESULTS FROM A TRIAL OF NIVOLUMAB ± IPILIMUMAB IN PATIENTS WITH RECURRENT GLIOBLASTOMA: CHECKMATE-143 Neuro-Oncology. 17: v70.2-v70. DOI: 10.1093/Neuonc/Nov211.06 |
0.403 |
|
| 2015 |
Goods BA, Lowther DE, Lucca L, Hernandez A, Lerner B, Gunel M, Raddassi K, Simon J, Coric V, Love JC, Hafler DA. CBM-05FUNCTIONAL DIFFERENCES BETWEEN PD-1+AND PD-1–CD4+T EFFECTOR CELLS IN HEALTHY DONORS AND PATIENTS WITH GLIOBLASTOMA Neuro-Oncology. 17: v70.1-v70. DOI: 10.1093/Neuonc/Nov211.05 |
0.352 |
|
| 2015 |
Lucca L, Goods BA, Lowther DE, Hernandez A, Lerner B, Gunel M, Raddassi K, Simon J, Latek R, Coric V, Love JC, Hafler DA. CBM-04PD-1 EXPRESSION IDENTIFIES EXHAUSTED TUMOR INFILTRATING REGULATORY T CELLS IN GLIOBLASTOMA Neuro-Oncology. 17: v69.4-v70. DOI: 10.1093/Neuonc/Nov211.04 |
0.371 |
|
| 2014 |
Stern JN, Yaari G, Vander Heiden JA, Church G, Donahue WF, Hintzen RQ, Huttner AJ, Laman JD, Nagra RM, Nylander A, Pitt D, Ramanan S, Siddiqui BA, Vigneault F, Kleinstein SH, ... Hafler DA, et al. B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes. Science Translational Medicine. 6: 248ra107. PMID 25100741 DOI: 10.1126/Scitranslmed.3008879 |
0.388 |
|
| 2014 |
Gautron AS, Dominguez-Villar M, de Marcken M, Hafler DA. Enhanced suppressor function of TIM-3+ FoxP3+ regulatory T cells. European Journal of Immunology. 44: 2703-11. PMID 24838857 DOI: 10.1002/Eji.201344392 |
0.468 |
|
| 2014 |
Kofler DM, Marson A, Dominguez-Villar M, Xiao S, Kuchroo VK, Hafler DA. Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells. The Journal of Clinical Investigation. 124: 2513-22. PMID 24812667 DOI: 10.1172/Jci72973 |
0.422 |
|
| 2014 |
Raj T, Rothamel K, Mostafavi S, Ye C, Lee MN, Replogle JM, Feng T, Lee M, Asinovski N, Frohlich I, Imboywa S, Von Korff A, Okada Y, Patsopoulos NA, Davis S, ... ... Hafler DA, et al. Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes. Science (New York, N.Y.). 344: 519-23. PMID 24786080 DOI: 10.1126/Science.1249547 |
0.418 |
|
| 2014 |
Joller N, Lozano E, Burkett PR, Patel B, Xiao S, Zhu C, Xia J, Tan TG, Sefik E, Yajnik V, Sharpe AH, Quintana FJ, Mathis D, Benoist C, Hafler DA, et al. Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. Immunity. 40: 569-81. PMID 24745333 DOI: 10.1016/J.Immuni.2014.02.012 |
0.429 |
|
| 2014 |
Xiao S, Yosef N, Yang J, Wang Y, Zhou L, Zhu C, Wu C, Baloglu E, Schmidt D, Ramesh R, Lobera M, Sundrud MS, Tsai PY, Xiang Z, Wang J, ... ... Hafler DA, et al. Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. Immunity. 40: 477-89. PMID 24745332 DOI: 10.1016/J.Immuni.2014.04.004 |
0.425 |
|
| 2014 |
Kleinewietfeld M, Hafler DA. Regulatory T cells in autoimmune neuroinflammation. Immunological Reviews. 259: 231-44. PMID 24712469 DOI: 10.1111/Imr.12169 |
0.513 |
|
| 2013 |
Patsopoulos NA, Barcellos LF, Hintzen RQ, Schaefer C, van Duijn CM, Noble JA, Raj T, Gourraud PA, Stranger BE, Oksenberg J, Olsson T, Taylor BV, Sawcer S, ... Hafler DA, et al. Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects. Plos Genetics. 9: e1003926. PMID 24278027 DOI: 10.1371/Journal.Pgen.1003926 |
0.325 |
|
| 2013 |
Kleinewietfeld M, Hafler DA. The plasticity of human Treg and Th17 cells and its role in autoimmunity. Seminars in Immunology. 25: 305-12. PMID 24211039 DOI: 10.1016/J.Smim.2013.10.009 |
0.495 |
|
| 2013 |
Ottoboni L, Frohlich IY, Lee M, Healy BC, Keenan BT, Xia Z, Chitnis T, Guttmann CR, Khoury SJ, Weiner HL, Hafler DA, De Jager PL. Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus. Neurology. 81: 1891-9. PMID 24174586 DOI: 10.1212/01.Wnl.0000436612.66328.8A |
0.592 |
|
| 2013 |
Beecham AH, Patsopoulos NA, Xifara DK, Davis MF, Kemppinen A, Cotsapas C, Shah TS, Spencer C, Booth D, Goris A, Oturai A, Saarela J, Fontaine B, Hemmer B, ... ... Hafler D, et al. Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nature Genetics. 45: 1353-60. PMID 24076602 DOI: 10.1038/Ng.2770 |
0.327 |
|
| 2013 |
Lozano E, Joller N, Cao Y, Kuchroo VK, Hafler DA. The CD226/CD155 interaction regulates the proinflammatory (Th1/Th17)/anti-inflammatory (Th2) balance in humans. Journal of Immunology (Baltimore, Md. : 1950). 191: 3673-80. PMID 23980210 DOI: 10.4049/Jimmunol.1300945 |
0.381 |
|
| 2013 |
Querol L, Clark PL, Bailey MA, Cotsapas C, Cross AH, Hafler DA, Kleinstein SH, Lee JY, Yaari G, Willis SN, O'Connor KC. Protein array-based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis. Neurology. 81: 956-63. PMID 23921886 DOI: 10.1212/Wnl.0B013E3182A43B48 |
0.406 |
|
| 2013 |
Poutahidis T, Kleinewietfeld M, Smillie C, Levkovich T, Perrotta A, Bhela S, Varian BJ, Ibrahim YM, Lakritz JR, Kearney SM, Chatzigiagkos A, Hafler DA, Alm EJ, Erdman SE. Microbial reprogramming inhibits Western diet-associated obesity. Plos One. 8: e68596. PMID 23874682 DOI: 10.1371/Journal.Pone.0068596 |
0.346 |
|
| 2013 |
Kinnunen T, Chamberlain N, Morbach H, Cantaert T, Lynch M, Preston-Hurlburt P, Herold KC, Hafler DA, O'Connor KC, Meffre E. Specific peripheral B cell tolerance defects in patients with multiple sclerosis. The Journal of Clinical Investigation. 123: 2737-41. PMID 23676463 DOI: 10.1172/Jci68775 |
0.414 |
|
| 2013 |
Van Haren K, Tomooka BH, Kidd BA, Banwell B, Bar-Or A, Chitnis T, Tenembaum SN, Pohl D, Rostasy K, Dale RC, O'Connor KC, Hafler DA, Steinman L, Robinson WH. Serum autoantibodies to myelin peptides distinguish acute disseminated encephalomyelitis from relapsing-remitting multiple sclerosis. Multiple Sclerosis (Houndmills, Basingstoke, England). 19: 1726-33. PMID 23612879 DOI: 10.1177/1352458513485653 |
0.383 |
|
| 2013 |
Larman HB, Laserson U, Querol L, Verhaeghen K, Solimini NL, Xu GJ, Klarenbeek PL, Church GM, Hafler DA, Plenge RM, Nigrovic PA, De Jager PL, Weets I, Martens GA, O'Connor KC, et al. PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis. Journal of Autoimmunity. 43: 1-9. PMID 23497938 DOI: 10.1016/J.Jaut.2013.01.013 |
0.353 |
|
| 2013 |
Kleinewietfeld M, Manzel A, Titze J, Kvakan H, Yosef N, Linker RA, Muller DN, Hafler DA. Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature. 496: 518-22. PMID 23467095 DOI: 10.1038/Nature11868 |
0.422 |
|
| 2013 |
Cotsapas C, Hafler DA. Immune-mediated disease genetics: the shared basis of pathogenesis. Trends in Immunology. 34: 22-6. PMID 23031829 DOI: 10.1016/J.It.2012.09.001 |
0.312 |
|
| 2013 |
Hernandez AL, O'Connor KC, Hafler DA. Multiple Sclerosis The Autoimmune Diseases: Fifth Edition. 735-756. DOI: 10.1016/B978-0-12-384929-8.00052-6 |
0.4 |
|
| 2013 |
Gawlik BB, Hafler DA. Regulatory T cells in MS Multiple Sclerosis Immunology: a Foundation For Current and Future Treatments. 27-47. DOI: 10.1007/978-1-4614-7953-6_2 |
0.375 |
|
| 2012 |
Ottoboni L, Keenan BT, Tamayo P, Kuchroo M, Mesirov JP, Buckle GJ, Khoury SJ, Hafler DA, Weiner HL, De Jager PL. An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity. Science Translational Medicine. 4: 153ra131. PMID 23019656 DOI: 10.1126/Scitranslmed.3004186 |
0.607 |
|
| 2012 |
Lee Y, Awasthi A, Yosef N, Quintana FJ, Xiao S, Peters A, Wu C, Kleinewietfeld M, Kunder S, Hafler DA, Sobel RA, Regev A, Kuchroo VK. Induction and molecular signature of pathogenic TH17 cells. Nature Immunology. 13: 991-9. PMID 22961052 DOI: 10.1038/Ni.2416 |
0.41 |
|
| 2012 |
Lowther DE, Hafler DA. Regulatory T cells in the central nervous system. Immunological Reviews. 248: 156-69. PMID 22725960 DOI: 10.1111/J.1600-065X.2012.01130.X |
0.443 |
|
| 2012 |
Kickler K, Maltby K, Ni Choileain S, Stephen J, Wright S, Hafler DA, Jabbour HN, Astier AL. Prostaglandin E2 affects T cell responses through modulation of CD46 expression. Journal of Immunology (Baltimore, Md. : 1950). 188: 5303-10. PMID 22544928 DOI: 10.4049/Jimmunol.1103090 |
0.427 |
|
| 2012 |
Nylander A, Hafler DA. Multiple sclerosis. The Journal of Clinical Investigation. 122: 1180-8. PMID 22466660 DOI: 10.1172/JCI58649 |
0.35 |
|
| 2012 |
Lozano E, Dominguez-Villar M, Kuchroo V, Hafler DA. The TIGIT/CD226 axis regulates human T cell function. Journal of Immunology (Baltimore, Md. : 1950). 188: 3869-75. PMID 22427644 DOI: 10.4049/Jimmunol.1103627 |
0.47 |
|
| 2012 |
Costantino CM, Spooner E, Ploegh HL, Hafler DA. Class II MHC self-antigen presentation in human B and T lymphocytes. Plos One. 7: e29805. PMID 22299025 DOI: 10.1371/Journal.Pone.0029805 |
0.413 |
|
| 2012 |
Pelletier D, Hafler DA. Fingolimod for multiple sclerosis. The New England Journal of Medicine. 366: 339-47. PMID 22276823 DOI: 10.1056/Nejmct1101691 |
0.334 |
|
| 2012 |
Han Q, Bagheri N, Bradshaw EM, Hafler DA, Lauffenburger DA, Love JC. Polyfunctional responses by human T cells result from sequential release of cytokines. Proceedings of the National Academy of Sciences of the United States of America. 109: 1607-12. PMID 22160692 DOI: 10.1073/Pnas.1117194109 |
0.406 |
|
| 2012 |
Kofler DM, Severson CA, Mousissian N, De Jager PL, Hafler DA. The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4 + T cell proliferation (Journal of Immunology (2011) 187, (3286-3291)) Journal of Immunology. 189: 2063. DOI: 10.4049/jimmunol.1290044 |
0.303 |
|
| 2011 |
Patsopoulos NA, Esposito F, Reischl J, Lehr S, Bauer D, Heubach J, Sandbrink R, Pohl C, Edan G, Kappos L, ... ... Hafler DA, et al. Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. Annals of Neurology. 70: 897-912. PMID 22190364 DOI: 10.1002/Ana.22609 |
0.561 |
|
| 2011 |
Cotsapas C, Voight BF, Rossin E, Lage K, Neale BM, Wallace C, Abecasis GR, Barrett JC, Behrens T, Cho J, De Jager PL, Elder JT, Graham RR, Gregersen P, Klareskog L, ... ... Hafler DA, et al. Pervasive sharing of genetic effects in autoimmune disease. Plos Genetics. 7: e1002254. PMID 21852963 DOI: 10.1371/Journal.Pgen.1002254 |
0.321 |
|
| 2011 |
Kofler DM, Severson CA, Mousissian N, De Jager PL, Hafler DA. The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation. Journal of Immunology (Baltimore, Md. : 1950). 187: 3286-91. PMID 21849685 DOI: 10.4049/Jimmunol.1100626 |
0.423 |
|
| 2011 |
Sawcer S, Hellenthal G, Pirinen M, Spencer CC, Patsopoulos NA, Moutsianas L, Dilthey A, Su Z, Freeman C, Hunt SE, Edkins S, Gray E, Booth DR, ... ... Hafler DA, et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature. 476: 214-9. PMID 21833088 DOI: 10.1038/Nature10251 |
0.378 |
|
| 2011 |
Raddassi K, Kent SC, Yang J, Bourcier K, Bradshaw EM, Seyfert-Margolis V, Nepom GT, Kwok WW, Hafler DA. Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis. Journal of Immunology (Baltimore, Md. : 1950). 187: 1039-46. PMID 21653833 DOI: 10.4049/Jimmunol.1001543 |
0.513 |
|
| 2011 |
Zuvich RL, Bush WS, McCauley JL, Beecham AH, De Jager PL, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Sawcer SJ, Pericak-Vance MA, Barcellos LF, Mortlock DP, Haines JL. Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA-CLEC16A-SOCS1 gene complex. Human Molecular Genetics. 20: 3517-24. PMID 21653641 DOI: 10.1093/Hmg/Ddr250 |
0.361 |
|
| 2011 |
Dominguez-Villar M, Baecher-Allan CM, Hafler DA. Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease. Nature Medicine. 17: 673-5. PMID 21540856 DOI: 10.1038/Nm.2389 |
0.478 |
|
| 2011 |
Vosslamber S, van der Voort LF, van den Elskamp IJ, Heijmans R, Aubin C, Uitdehaag BM, Crusius JB, van der Pouw Kraan TC, van der PouwKraan TC, Comabella M, Montalban X, Hafler DA, De Jager PL, Killestein J, Polman CH, et al. Interferon regulatory factor 5 gene variants and pharmacological and clinical outcome of Interferonβ therapy in multiple sclerosis. Genes and Immunity. 12: 466-72. PMID 21471993 DOI: 10.1038/Gene.2011.18 |
0.32 |
|
| 2011 |
Dominguez-Villar M, Hafler DA. Immunology. An innate role for IL-17. Science (New York, N.Y.). 332: 47-8. PMID 21454778 DOI: 10.1126/Science.1205311 |
0.392 |
|
| 2011 |
Obermeier B, Lovato L, Mentele R, Brück W, Forne I, Imhof A, Lottspeich F, Turk KW, Willis SN, Wekerle H, Hohlfeld R, Hafler DA, O'Connor KC, Dornmair K. Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin. Journal of Neuroimmunology. 233: 245-8. PMID 21353315 DOI: 10.1016/J.Jneuroim.2011.01.010 |
0.313 |
|
| 2011 |
Baecher-Allan CM, Costantino CM, Cvetanovich GL, Ashley CW, Beriou G, Dominguez-Villar M, Hafler DA. CD2 costimulation reveals defective activity by human CD4+CD25(hi) regulatory cells in patients with multiple sclerosis. Journal of Immunology (Baltimore, Md. : 1950). 186: 3317-26. PMID 21300823 DOI: 10.4049/Jimmunol.1002502 |
0.396 |
|
| 2011 |
Wang JH, Pappas D, De Jager PL, Pelletier D, de Bakker PI, Kappos L, Polman CH, Chibnik LB, Hafler DA, Matthews PM, Hauser SL, Baranzini SE, Oksenberg JR. Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data. Genome Medicine. 3: 3. PMID 21244703 DOI: 10.1186/Gm217 |
0.33 |
|
| 2011 |
Lovato L, Willis SN, Rodig SJ, Caron T, Almendinger SE, Howell OW, Reynolds R, O'Connor KC, Hafler DA. Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis. Brain : a Journal of Neurology. 134: 534-41. PMID 21216828 DOI: 10.1093/Brain/Awq350 |
0.391 |
|
| 2011 |
Gross R, Healy BC, Cepok S, Chitnis T, Khoury SJ, Hemmer B, Weiner HL, Hafler DA, De Jager PL. Population structure and HLA DRB1 1501 in the response of subjects with multiple sclerosis to first-line treatments. Journal of Neuroimmunology. 233: 168-74. PMID 21115201 DOI: 10.1016/J.Jneuroim.2010.10.038 |
0.527 |
|
| 2011 |
Konry T, Dominguez-Villar M, Baecher-Allan C, Hafler DA, Yarmush ML. Droplet-based microfluidic platforms for single T cell secretion analysis of IL-10 cytokine. Biosensors & Bioelectronics. 26: 2707-10. PMID 20888750 DOI: 10.1016/J.Bios.2010.09.006 |
0.373 |
|
| 2010 |
Cvetanovich GL, Hafler DA. Human regulatory T cells in autoimmune diseases. Current Opinion in Immunology. 22: 753-60. PMID 20869862 DOI: 10.1016/J.Coi.2010.08.012 |
0.396 |
|
| 2010 |
Khoury SJ, Healy BC, Kivisäkk P, Viglietta V, Egorova S, Guttmann CR, Wedgwood JF, Hafler DA, Weiner HL, Buckle G, Cook S, Reddy S. A randomized controlled double-masked trial of albuterol add-on therapy in patients with multiple sclerosis. Archives of Neurology. 67: 1055-61. PMID 20837847 DOI: 10.1001/Archneurol.2010.222 |
0.565 |
|
| 2010 |
Healy BC, Liguori M, Tran D, Chitnis T, Glanz B, Wolfish C, Gauthier S, Buckle G, Houtchens M, Stazzone L, Khoury S, Hartzmann R, Fernandez-Vina M, Hafler DA, Weiner HL, et al. HLA B*44: protective effects in MS susceptibility and MRI outcome measures. Neurology. 75: 634-40. PMID 20713950 DOI: 10.1212/Wnl.0B013E3181Ed9C9C |
0.584 |
|
| 2010 |
Briggs FB, Bartlett SE, Goldstein BA, Wang J, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, et al. Evidence for CRHR1 in multiple sclerosis using supervised machine learning and meta-analysis in 12,566 individuals. Human Molecular Genetics. 19: 4286-95. PMID 20699326 DOI: 10.1093/Hmg/Ddq328 |
0.363 |
|
| 2010 |
Ligocki AJ, Lovato L, Xiang D, Guidry P, Scheuermann RH, Willis SN, Almendinger S, Racke MK, Frohman EM, Hafler DA, O'Connor KC, Monson NL. A unique antibody gene signature is prevalent in the central nervous system of patients with multiple sclerosis. Journal of Neuroimmunology. 226: 192-3. PMID 20655601 DOI: 10.1016/J.Jneuroim.2010.06.016 |
0.386 |
|
| 2010 |
Cree BA, Rioux JD, McCauley JL, Gourraud PA, Goyette P, McElroy J, De Jager P, Santaniello A, Vyse TJ, Gregersen PK, Mirel D, Hafler DA, Haines JL, Pericak-Vance MA, Compston A, et al. A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01. Plos One. 5: e11296. PMID 20593013 DOI: 10.1371/Journal.Pone.0011296 |
0.319 |
|
| 2010 |
Sakaguchi S, Miyara M, Costantino CM, Hafler DA. FOXP3+ regulatory T cells in the human immune system. Nature Reviews. Immunology. 10: 490-500. PMID 20559327 DOI: 10.1038/Nri2785 |
0.454 |
|
| 2010 |
Briggs FB, Goldstein BA, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, Haines JL, Barcellos LF, et al. Variation within DNA repair pathway genes and risk of multiple sclerosis. American Journal of Epidemiology. 172: 217-24. PMID 20522537 DOI: 10.1093/Aje/Kwq086 |
0.337 |
|
| 2010 |
Beriou G, Bradshaw EM, Lozano E, Costantino CM, Hastings WD, Orban T, Elyaman W, Khoury SJ, Kuchroo VK, Baecher-Allan C, Hafler DA. TGF-beta induces IL-9 production from human Th17 cells. Journal of Immunology (Baltimore, Md. : 1950). 185: 46-54. PMID 20498357 DOI: 10.4049/Jimmunol.1000356 |
0.312 |
|
| 2010 |
Han Q, Bradshaw EM, Nilsson B, Hafler DA, Love JC. Multidimensional analysis of the frequencies and rates of cytokine secretion from single cells by quantitative microengraving. Lab On a Chip. 10: 1391-400. PMID 20376398 DOI: 10.1039/B926849A |
0.373 |
|
| 2010 |
Bronson PG, Caillier S, Ramsay PP, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Sawcer SJ, Pericak-Vance MA, Haines JL, Hauser SL, et al. CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis. Human Molecular Genetics. 19: 2331-40. PMID 20211854 DOI: 10.1093/Hmg/Ddq101 |
0.317 |
|
| 2010 |
Jakkula E, Leppä V, Sulonen AM, Varilo T, Kallio S, Kemppinen A, Purcell S, Koivisto K, Tienari P, Sumelahti ML, Elovaara I, Pirttilä T, Reunanen M, Aromaa A, Oturai AB, ... ... Hafler DA, et al. Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene. American Journal of Human Genetics. 86: 285-91. PMID 20159113 DOI: 10.1016/J.Ajhg.2010.01.017 |
0.339 |
|
| 2010 |
Zuvich RL, McCauley JL, Oksenberg JR, Sawcer SJ, De Jager PL, Aubin C, Cross AH, Piccio L, Aggarwal NT, Evans D, Hafler DA, Compston A, Hauser SL, Pericak-Vance MA, et al. Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility. Human Genetics. 127: 525-35. PMID 20112030 DOI: 10.1007/S00439-010-0789-4 |
0.333 |
|
| 2010 |
Astier AL, Beriou G, Eisenhaure TM, Anderton SM, Hafler DA, Hacohen N. RNA interference screen in primary human T cells reveals FLT3 as a modulator of IL-10 levels. Journal of Immunology (Baltimore, Md. : 1950). 184: 685-93. PMID 20018615 DOI: 10.4049/Jimmunol.0902443 |
0.417 |
|
| 2010 |
Song Q, Han Q, Bradshaw EM, Kent SC, Raddassi K, Nilsson B, Nepom GT, Hafler DA, Love JC. On-chip activation and subsequent detection of individual antigen-specific T cells. Analytical Chemistry. 82: 473-7. PMID 20000848 DOI: 10.1021/Ac9024363 |
0.476 |
|
| 2010 |
Severson C, Hafler DA. T-cells in multiple sclerosis. Results and Problems in Cell Differentiation. 51: 75-98. PMID 19582415 DOI: 10.1007/400_2009_12 |
0.517 |
|
| 2010 |
Dominguez-Villar M, Hafler D, Baecher-Allan C. IL-12 Induces Human CD4+CD45RA-CD25hiCD127low/neg Regulatory T Cells to Secrete IFNγ and IL-10 and Acquire a Non-regulatory Effector Phenotype Clinical Immunology. 135. DOI: 10.1016/J.Clim.2010.03.400 |
0.363 |
|
| 2010 |
Cvetanovich G, Bradshaw E, Beriou G, Mousissian N, Baecher-Allan C, Hafler D. IL-1 Receptor Expression on Human Regulatory T Cells and IL-1β's Role in Reducing Suppression Clinical Immunology. 135. DOI: 10.1016/J.Clim.2010.03.395 |
0.324 |
|
| 2010 |
Ottoboni L, Mousissian N, Castillo IW, Hafler D, Jager PD. Dissecting the Functional Consequences of the Validated Multiple Sclerosis Susceptibility Allele in TNFRSF1A Clinical Immunology. 135. DOI: 10.1016/J.Clim.2010.03.351 |
0.325 |
|
| 2010 |
Schubert D, Gordo S, Vardhana S, Pyrdol J, Seth N, Raddassi K, Hafler D, Dustin M, Wucherpfennig K. Altered Synapse Formation by Self-reactive T Cells from MS Patients Clinical Immunology. 135: S75-S76. DOI: 10.1016/J.Clim.2010.03.227 |
0.614 |
|
| 2010 |
Gordo S, Schubert D, Vardhana S, Seth N, Pyrdol J, Raddassi K, Hafler D, Dustin M, Wucherpfennig K. Efficient Activation of Self-reactive T Cells from MS Patients with Altered Synapse Formation Clinical Immunology. 135. DOI: 10.1016/J.Clim.2010.03.031 |
0.611 |
|
| 2009 |
De Jager PL, Chibnik LB, Cui J, Reischl J, Lehr S, Simon KC, Aubin C, Bauer D, Heubach JF, Sandbrink R, Tyblova M, Lelkova P, ... ... Hafler DA, et al. Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score. The Lancet. Neurology. 8: 1111-9. PMID 19879194 DOI: 10.1016/S1474-4422(09)70275-3 |
0.344 |
|
| 2009 |
Rioux JD, Goyette P, Vyse TJ, Hammarström L, Fernando MM, Green T, De Jager PL, Foisy S, Wang J, de Bakker PI, Leslie S, McVean G, Padyukov L, Alfredsson L, ... ... Hafler DA, et al. Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases. Proceedings of the National Academy of Sciences of the United States of America. 106: 18680-5. PMID 19846760 DOI: 10.1073/Pnas.0909307106 |
0.331 |
|
| 2009 |
Liu DV, Maier LM, Hafler DA, Wittrup KD. Engineered interleukin-2 antagonists for the inhibition of regulatory T cells. Journal of Immunotherapy (Hagerstown, Md. : 1997). 32: 887-94. PMID 19816193 DOI: 10.1097/Cji.0B013E3181B528Da |
0.343 |
|
| 2009 |
Bradshaw EM, Raddassi K, Elyaman W, Orban T, Gottlieb PA, Kent SC, Hafler DA. Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells. Journal of Immunology (Baltimore, Md. : 1950). 183: 4432-9. PMID 19748982 DOI: 10.4049/Jimmunol.0900576 |
0.396 |
|
| 2009 |
McLaughlin KA, Chitnis T, Newcombe J, Franz B, Kennedy J, McArdel S, Kuhle J, Kappos L, Rostasy K, Pohl D, Gagne D, Ness JM, Tenembaum S, O'Connor KC, Viglietta V, ... ... Hafler DA, et al. Age-dependent B cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosis. Journal of Immunology (Baltimore, Md. : 1950). 183: 4067-76. PMID 19687098 DOI: 10.4049/Jimmunol.0801888 |
0.593 |
|
| 2009 |
Hastings WD, Anderson DE, Kassam N, Koguchi K, Greenfield EA, Kent SC, Zheng XX, Strom TB, Hafler DA, Kuchroo VK. TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. European Journal of Immunology. 39: 2492-501. PMID 19676072 DOI: 10.1002/Eji.200939274 |
0.437 |
|
| 2009 |
Willis SN, Stadelmann C, Rodig SJ, Caron T, Gattenloehner S, Mallozzi SS, Roughan JE, Almendinger SE, Blewett MM, Brück W, Hafler DA, O'Connor KC. Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain. Brain : a Journal of Neurology. 132: 3318-28. PMID 19638446 DOI: 10.1093/Brain/Awp200 |
0.346 |
|
| 2009 |
Owens GP, Bennett JL, Lassmann H, O'Connor KC, Ritchie AM, Shearer A, Lam C, Yu X, Birlea M, DuPree C, Williamson RA, Hafler DA, Burgoon MP, Gilden D. Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid. Annals of Neurology. 65: 639-49. PMID 19557869 DOI: 10.1002/Ana.21641 |
0.397 |
|
| 2009 |
Costantino CM, Ploegh HL, Hafler DA. Cathepsin S regulates class II MHC processing in human CD4+ HLA-DR+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 183: 945-52. PMID 19553543 DOI: 10.4049/Jimmunol.0900921 |
0.426 |
|
| 2009 |
De Jager PL, Jia X, Wang J, de Bakker PI, Ottoboni L, Aggarwal NT, Piccio L, Raychaudhuri S, Tran D, Aubin C, Briskin R, Romano S, Baranzini SE, McCauley JL, ... ... Hafler DA, et al. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nature Genetics. 41: 776-82. PMID 19525953 DOI: 10.1038/Ng.401 |
0.579 |
|
| 2009 |
Maier LM, Hafler DA. Autoimmunity risk alleles in costimulation pathways. Immunological Reviews. 229: 322-36. PMID 19426231 DOI: 10.1111/J.1600-065X.2009.00777.X |
0.408 |
|
| 2009 |
De Jager PL, Baecher-Allan C, Maier LM, Arthur AT, Ottoboni L, Barcellos L, McCauley JL, Sawcer S, Goris A, Saarela J, Yelensky R, Price A, Leppa V, Patterson N, de Bakker PI, ... ... Hafler DA, et al. The role of the CD58 locus in multiple sclerosis. Proceedings of the National Academy of Sciences of the United States of America. 106: 5264-9. PMID 19237575 DOI: 10.1073/Pnas.0813310106 |
0.613 |
|
| 2009 |
Kallio SP, Jakkula E, Purcell S, Suvela M, Koivisto K, Tienari PJ, Elovaara I, Pirttilä T, Reunanen M, Bronnikov D, Viander M, Meri S, Hillert J, Lundmark F, Harbo HF, ... ... Hafler DA, et al. Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS. Human Molecular Genetics. 18: 1670-83. PMID 19221116 DOI: 10.1093/Hmg/Ddp073 |
0.361 |
|
| 2009 |
Beriou G, Costantino CM, Ashley CW, Yang L, Kuchroo VK, Baecher-Allan C, Hafler DA. IL-17-producing human peripheral regulatory T cells retain suppressive function. Blood. 113: 4240-9. PMID 19171879 DOI: 10.1182/Blood-2008-10-183251 |
0.345 |
|
| 2009 |
Maier LM, Anderson DE, Severson CA, Baecher-Allan C, Healy B, Liu DV, Wittrup KD, De Jager PL, Hafler DA. Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses. Journal of Immunology (Baltimore, Md. : 1950). 182: 1541-7. PMID 19155502 DOI: 10.4049/Jimmunol.182.3.1541 |
0.375 |
|
| 2009 |
Maier LM, Lowe CE, Cooper J, Downes K, Anderson DE, Severson C, Clark PM, Healy B, Walker N, Aubin C, Oksenberg JR, Hauser SL, Compston A, Sawcer S, ... ... Hafler DA, et al. IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. Plos Genetics. 5: e1000322. PMID 19119414 DOI: 10.1371/Journal.Pgen.1000322 |
0.379 |
|
| 2009 |
Costantino C, Ploegh H, Hafler D. S.132. Cathepsin S Regulates MHC Class II Processing in Human CD4+HLA-DR+T Cells Clinical Immunology. 131: S168. DOI: 10.1016/J.Clim.2009.03.498 |
0.364 |
|
| 2009 |
Ashley C, Hafler D, Baecher-Allan C. S.119. CD127 and HLA DR Define Functionally Distinct Human Tregs- One Subsets Exhibits Decreased Activity in Multiple Sclerosis Clinical Immunology. 131. DOI: 10.1016/J.Clim.2009.03.487 |
0.376 |
|
| 2009 |
Raddassi K, Yang J, Kent S, Bradshaw E, Bourcier K, Seyfert-Margolis V, Kwok W, Hafler D. S.67. Detection of Myelin Reactive CD4+Cells in the Peripheral Blood of Patients with Multiple Sclerosis using MHC Class II Tetramers Clinical Immunology. 131. DOI: 10.1016/J.Clim.2009.03.444 |
0.384 |
|
| 2009 |
Cvetanovich G, Ashley C, Hafler D, Baecher-Allan C. F.108. DNA Methylation of the Human FoxP3 Locus Differs Significantly Between Functionally Distinct Subpopulations of CD4+CD25high Human Regulatory T Cells Clinical Immunology. 131. DOI: 10.1016/J.Clim.2009.03.361 |
0.357 |
|
| 2009 |
Willis S, Almendinger S, Lovato L, Hafler D, O'Connor K. F.89. Elucidating the Antigen Specificity of B Cells Present within the CNS Lesions of Patients with MS Clinical Immunology. 131. DOI: 10.1016/J.Clim.2009.03.346 |
0.371 |
|
| 2009 |
Jager PD, Bakker Pd, Wang J, Ottoboni L, Hauser S, Oksenberg J, Hafler D. F.27. Meta-analysis of Genome Scans and Replication Identify CD6, ICSBP1, and TNFRSF1A as Novel Multiple Sclerosis Susceptibility Loci Clinical Immunology. 131. DOI: 10.1016/J.Clim.2009.03.294 |
0.306 |
|
| 2009 |
Bradshaw E, Raddassi K, Elyaman W, Orban T, Gottlieb P, Kent S, Hafler D. T.22. Monocytes from Patients with Type 1 Diabetes Spontaneously Secrete Pro-inflammatory Cytokines Inducing Th17 Cells Clinical Immunology. 131. DOI: 10.1016/J.Clim.2009.03.163 |
0.371 |
|
| 2009 |
Beriou G, Costantino C, Baecher-Allan C, Hafler D. OR.55. Transforming Growth Factor-beta is Crucial for the Differentiation and Regulation of Interleukin 9-producing Human CD4+T Cells Clinical Immunology. 131. DOI: 10.1016/J.Clim.2009.03.067 |
0.366 |
|
| 2009 |
Lovato L, Almendinger S, Willis S, Rodig S, Hafler D, O'Connor K. OR.43. Comparative Analysis of B Cell Repertoires Among Lesions and Normal Appearing White Matter in the Multiple Sclerosis Central Nervous System Clinical Immunology. 131. DOI: 10.1016/J.Clim.2009.03.055 |
0.341 |
|
| 2009 |
Costantino C, Beriou G, Ashley C, Hafler D, Baecher-Allan C. OR.4. Cellular Senescence in Terminally Differentiated Human CD4+CD25hi IL-7Rneg HLA-DR+Regulatory T Cells Clinical Immunology. 131. DOI: 10.1016/J.Clim.2009.03.011 |
0.409 |
|
| 2008 |
Hafler DA, Kuchroo V. TIMs: central regulators of immune responses. The Journal of Experimental Medicine. 205: 2699-701. PMID 19015312 DOI: 10.1084/Jem.20082429 |
0.405 |
|
| 2008 |
Viglietta V, Bourcier K, Buckle GJ, Healy B, Weiner HL, Hafler DA, Egorova S, Guttmann CR, Rusche JR, Khoury SJ. CTLA4Ig treatment in patients with multiple sclerosis: an open-label, phase 1 clinical trial. Neurology. 71: 917-24. PMID 18794494 DOI: 10.1212/01.Wnl.0000325915.00112.61 |
0.68 |
|
| 2008 |
Costantino CM, Baecher-Allan C, Hafler DA. Multiple sclerosis and regulatory T cells. Journal of Clinical Immunology. 28: 697-706. PMID 18763026 DOI: 10.1007/S10875-008-9236-X |
0.535 |
|
| 2008 |
Bradshaw EM, Kent SC, Tripuraneni V, Orban T, Ploegh HL, Hafler DA, Love JC. Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies. Clinical Immunology (Orlando, Fla.). 129: 10-8. PMID 18675591 DOI: 10.1016/J.Clim.2008.06.009 |
0.389 |
|
| 2008 |
De Jager PL, Rossin E, Pyne S, Tamayo P, Ottoboni L, Viglietta V, Weiner M, Soler D, Izmailova E, Faron-Yowe L, O'Brien C, Freeman S, Granados S, Parker A, Roubenoff R, ... ... Hafler DA, et al. Cytometric profiling in multiple sclerosis uncovers patient population structure and a reduction of CD8low cells. Brain : a Journal of Neurology. 131: 1701-11. PMID 18567923 DOI: 10.1093/Brain/Awn118 |
0.589 |
|
| 2008 |
Yang L, Anderson DE, Baecher-Allan C, Hastings WD, Bettelli E, Oukka M, Kuchroo VK, Hafler DA. IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature. 454: 350-2. PMID 18469800 DOI: 10.1038/Nature07021 |
0.416 |
|
| 2008 |
Vaknin-Dembinsky A, Murugaiyan G, Hafler DA, Astier AL, Weiner HL. Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosis. Journal of Neuroimmunology. 195: 140-5. PMID 18403025 DOI: 10.1016/J.Jneuroim.2008.01.002 |
0.624 |
|
| 2008 |
Costantino CM, Baecher-Allan CM, Hafler DA. Human regulatory T cells and autoimmunity. European Journal of Immunology. 38: 921-4. PMID 18395861 DOI: 10.1002/Eji.200738104 |
0.45 |
|
| 2008 |
Rodriguez-Manzanet R, Meyers JH, Balasubramanian S, Slavik J, Kassam N, Dardalhon V, Greenfield EA, Anderson AC, Sobel RA, Hafler DA, Strom TB, Kuchroo VK. TIM-4 expressed on APCs induces T cell expansion and survival. Journal of Immunology (Baltimore, Md. : 1950). 180: 4706-13. PMID 18354194 DOI: 10.4049/Jimmunol.180.7.4706 |
0.445 |
|
| 2008 |
Yang L, Anderson DE, Kuchroo J, Hafler DA. Lack of TIM-3 immunoregulation in multiple sclerosis. Journal of Immunology (Baltimore, Md. : 1950). 180: 4409-14. PMID 18354161 DOI: 10.4049/Jimmunol.180.7.4409 |
0.529 |
|
| 2008 |
De Jager PL, Simon KC, Munger KL, Rioux JD, Hafler DA, Ascherio A. Integrating risk factors: HLA-DRB1*1501 and Epstein-Barr virus in multiple sclerosis. Neurology. 70: 1113-8. PMID 18272866 DOI: 10.1212/01.Wnl.0000294325.63006.F8 |
0.345 |
|
| 2008 |
Maier LM, Hafler DA. The developing mosaic of autoimmune disease risk. Nature Genetics. 40: 131-2. PMID 18227869 DOI: 10.1038/Ng0208-131 |
0.303 |
|
| 2008 |
Baecher-Allan C, Hafler DA. Response to comment on "MHC class II expression identifies functionally distinct human regulatory T cells" Journal of Immunology. 180: 3626. DOI: 10.4049/Jimmunol.180.6.3626 |
0.371 |
|
| 2008 |
Baecher-Allan C, Beriou G, Yang L, Hastings W, Anderson D, Kuchroo VK, Hafler DA. SY-23 Human CD4+CD25high natural Tregs and Th17 effector cells are related Cytokine. 43: 305. DOI: 10.1016/J.Cyto.2008.07.340 |
0.36 |
|
| 2008 |
Baecher-Allan C, Maier L, Beriou G, Ashley C, Hafler D. Sa.115. IL7R and HLA-Class II selected FoxP3+ Natural Regulatory T Cells (nTregs) Represent Effector nTregs, Precursor nTregs, and Induced nTregs Clinical Immunology. 127. DOI: 10.1016/J.Clim.2008.03.336 |
0.384 |
|
| 2008 |
Jager PD, Kivisäkk P, Hu X, Soler-Ferran D, Izmailova E, O'Brien C, Hafler D, Weiner H, Khoury S. F.34. Changes in the CD8dimCD4- Cell Population Parallel Disease Activity in Treated Multiple Sclerosis Subjects Clinical Immunology. 127: S54. DOI: 10.1016/J.Clim.2008.03.146 |
0.564 |
|
| 2008 |
McLaughlin K, Chitnis T, Banwell B, Bar-Or A, Kuhle J, Kappos L, Rostasy K, Pohl D, Wong S, Tavakoli N, Tenembaum S, Franz B, O'Connor K, Hafler D, Wucherpfennig K. F.14. Autoantibodies to Myelin Oligodendrocyte Glycoprotein in Pediatric MS Clinical Immunology. 127: S47-S48. DOI: 10.1016/J.Clim.2008.03.126 |
0.547 |
|
| 2008 |
De Jager P, Baecher-Allan C, Maier L, Sawcer S, Goris A, Saarela J, Barcellos L, Dubois B, Peltonen L, Palotie A, Weiner H, Booth D, Stewart G, Pericak-Vance M, Haines J, ... ... Hafler D, et al. OR.102. The CD58 Pathway is Implicated in MS Susceptibility Clinical Immunology. 127: S40-S41. DOI: 10.1016/J.Clim.2008.03.109 |
0.579 |
|
| 2008 |
Astier A, Beriou G, Eisenhaure T, Hafler D, Hacohen N. Flt3, a New Regulator of IL-10 Production by Human T Cells, Identified Using an RNAi Library Clinical Immunology. 127. DOI: 10.1016/J.Clim.2008.03.074 |
0.366 |
|
| 2008 |
Beriou G, Ashley C, Constantino C, Hafler D, Baecher-Allan C. OR.39. Differentiation of Natural Human CD4+CD25high Tregs to Th17 Effector Cells Clinical Immunology. 127. DOI: 10.1016/J.Clim.2008.03.045 |
0.362 |
|
| 2007 |
Anderson AC, Anderson DE, Bregoli L, Hastings WD, Kassam N, Lei C, Chandwaskar R, Karman J, Su EW, Hirashima M, Bruce JN, Kane LP, Kuchroo VK, Hafler DA. Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells. Science (New York, N.Y.). 318: 1141-3. PMID 18006747 DOI: 10.1126/Science.1148536 |
0.395 |
|
| 2007 |
Maier LM, Anderson DE, De Jager PL, Wicker LS, Hafler DA. Allelic variant in CTLA4 alters T cell phosphorylation patterns. Proceedings of the National Academy of Sciences of the United States of America. 104: 18607-12. PMID 18000051 DOI: 10.1073/Pnas.0706409104 |
0.455 |
|
| 2007 |
Astier AL, Hafler DA. Abnormal Tr1 differentiation in multiple sclerosis Journal of Neuroimmunology. 191: 70-78. PMID 17936368 DOI: 10.1016/J.Jneuroim.2007.09.018 |
0.515 |
|
| 2007 |
Ousman SS, Tomooka BH, van Noort JM, Wawrousek EF, O'Connor KC, Hafler DA, Sobel RA, Robinson WH, Steinman L. Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination. Nature. 448: 474-9. PMID 17568699 DOI: 10.1038/Nature05935 |
0.447 |
|
| 2007 |
Wucherpfennig KW, Allen PM, Celada F, Cohen IR, De Boer R, Garcia KC, Goldstein B, Greenspan R, Hafler D, Hodgkin P, Huseby ES, Krakauer DC, Nemazee D, Perelson AS, Pinilla C, et al. Polyspecificity of T cell and B cell receptor recognition. Seminars in Immunology. 19: 216-24. PMID 17398114 DOI: 10.1016/J.Smim.2007.02.012 |
0.591 |
|
| 2007 |
Cai G, Hafler DA. Multispecific responses by T cells expanded by endogenous self-peptide/MHC complexes European Journal of Immunology. 37: 602-612. PMID 17304631 DOI: 10.1002/Eji.200636787 |
0.431 |
|
| 2007 |
Yeo TW, De Jager PL, Gregory SG, Barcellos LF, Walton A, Goris A, Fenoglio C, Ban M, Taylor CJ, Goodman RS, Walsh E, Wolfish CS, Horton R, Traherne J, Beck S, ... ... Hafler DA, et al. A second major histocompatibility complex susceptibility locus for multiple sclerosis. Annals of Neurology. 61: 228-36. PMID 17252545 DOI: 10.1002/Ana.21063 |
0.31 |
|
| 2007 |
O'Connor KC, McLaughlin KA, De Jager PL, Chitnis T, Bettelli E, Xu C, Robinson WH, Cherry SV, Bar-Or A, Banwell B, Fukaura H, Fukazawa T, Tenembaum S, Wong SJ, Tavakoli NP, ... ... Hafler DA, et al. Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein. Nature Medicine. 13: 211-7. PMID 17237795 DOI: 10.1038/Nm1488 |
0.588 |
|
| 2007 |
De Jager PL, Hafler DA. New therapeutic approaches for multiple sclerosis Annual Review of Medicine. 58: 417-432. PMID 17217332 DOI: 10.1146/Annurev.Med.58.071105.111552 |
0.406 |
|
| 2007 |
Bradshaw EM, Orihuela A, McArdel SL, Salajegheh M, Amato AA, Hafler DA, Greenberg SA, O'Connor KC. A local antigen-driven humoral response is present in the inflammatory myopathies. Journal of Immunology (Baltimore, Md. : 1950). 178: 547-56. PMID 17182595 DOI: 10.4049/Jimmunol.178.1.547 |
0.349 |
|
| 2007 |
Hafler DA. Cytokines and interventional immunology Nature Reviews Immunology. 7: 423. DOI: 10.1038/Nri2101 |
0.307 |
|
| 2007 |
McLaughlin K, O'Connor K, Hafler D, Wucherpfennig K. Detection of autoantibodies with self-assembling radiolabeled antigen tetramers Nature Protocols. DOI: 10.1038/Nprot.2007.81 |
0.486 |
|
| 2007 |
Raddassi K, Bouchier K, Estevam J, Seyfert-Margolis V, Hafler D. Elifacs: A Multiplex Assay to Detect Antigen Specific T Cells and to Monitor the Immune Response Clinical Immunology. 123. DOI: 10.1016/J.Clim.2007.03.538 |
0.392 |
|
| 2007 |
Manzanet RR, Hartt-Meyers J, Slavik J, Dardalhon V, Kassam N, Greenfield EA, Sobel RA, Strom TB, Hafler DA, Kuchroo VK. Tim-4 Expressed on Antigen-presenting Cells Induces T Cell Expansion and Survival Clinical Immunology. 123: S124-S125. DOI: 10.1016/J.Clim.2007.03.533 |
0.417 |
|
| 2007 |
Costanti-England C, Hang H, Hafler D, Ploegh H. Haplotype-specific Use of Lysosomal Proteases Can Modulate the Class II MHC Peptide Repertoire but Does Not Impair Invariant Chain Degradation in Human Antigen Presenting Cells Clinical Immunology. 123: S53. DOI: 10.1016/J.Clim.2007.03.330 |
0.3 |
|
| 2007 |
Hastings W, Greer A, Kuchroo V, Hafler D, Kent S, Anderson D. Dysregulation of the TIM-3-Galectin-9 Pathway in Type I Diabetic T Cells Clinical Immunology. 123: S21. DOI: 10.1016/J.Clim.2007.03.228 |
0.339 |
|
| 2007 |
Anderson DE, Kuchroo J, Kassam N, Hafler D. TIM-3 is a Negative Regulator of Human Th1 Cells Clinical Immunology. 123. DOI: 10.1016/J.Clim.2007.03.079 |
0.317 |
|
| 2007 |
Raddassi K, Bourcier K, Estevam J, Seyfert-Margolis V, Hafler D. Improving Elispot to Detect Antigen Specific T Cells Clinical Immunology. 123. DOI: 10.1016/J.Clim.2007.03.078 |
0.406 |
|
| 2007 |
Rossin E, Viglietta V, Soler-Ferran D, Parker A, Weiner M, Buckle G, Khoury S, Hafler D, Weiner H, De Jager P. Large Scale Immunoprofiling Uncovers Population Structure in Untreated MS Subjects and Highlights the Role of NK Cells Clinical Immunology. 123: S151. DOI: 10.1016/J.Clim.2007.03.068 |
0.568 |
|
| 2007 |
Yang L, Anderson DE, Kuchroo VK, Hafler DA. Defect in TIM-3 Regulation of CD4+ T Cells in a Human Autoimmune Disease Clinical Immunology. 123: S139-S140. DOI: 10.1016/J.Clim.2007.03.035 |
0.431 |
|
| 2006 |
Baecher-Allan CM, Hafler DA. The purification and functional analysis of human CD4+CD25high regulatory T cells. Current Protocols in Immunology / Edited by John E. Coligan ... [Et Al.]. Unit 7.4B. PMID 18432975 DOI: 10.1002/0471142735.Im0704Bs72 |
0.403 |
|
| 2006 |
O'Connor KC, Roy SM, Becker CH, Hafler DA, Kantor AB. Comprehensive phenotyping in multiple sclerosis: discovery based proteomics and the current understanding of putative biomarkers. Disease Markers. 22: 213-25. PMID 17124343 DOI: 10.1155/2006/670439 |
0.352 |
|
| 2006 |
Astier AL, Meiffren G, Freeman S, Hafler DA. Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis. The Journal of Clinical Investigation. 116: 3252-7. PMID 17099776 DOI: 10.1172/Jci29251 |
0.439 |
|
| 2006 |
Karni A, Abraham M, Monsonego A, Cai G, Freeman GJ, Hafler D, Khoury SJ, Weiner HL. Innate immunity in multiple sclerosis: myeloid dendritic cells in secondary progressive multiple sclerosis are activated and drive a proinflammatory immune response. Journal of Immunology (Baltimore, Md. : 1950). 177: 4196-202. PMID 16951385 DOI: 10.4049/Jimmunol.177.6.4196 |
0.637 |
|
| 2006 |
Baecher-Allan C, Hafler DA. Human regulatory T cells and their role in autoimmune disease Immunological Reviews. 212: 203-216. PMID 16903916 DOI: 10.1111/J.0105-2896.2006.00417.X |
0.482 |
|
| 2006 |
Koguchi K, Anderson DE, Yang L, O'Connor KC, Kuchroo VK, Hafler DA. Dysregulated T cell expression of TIM3 in multiple sclerosis. The Journal of Experimental Medicine. 203: 1413-8. PMID 16754722 DOI: 10.1084/Jem.20060210 |
0.507 |
|
| 2006 |
De Jager PL, Graham R, Farwell L, Sawcer S, Richardson A, Behrens TW, Compston A, Hafler DA, Kere J, Vyse TJ, Rioux JD. The role of inflammatory bowel disease susceptibility loci in multiple sclerosis and systemic lupus erythematosus. Genes and Immunity. 7: 327-34. PMID 16642031 DOI: 10.1038/Sj.Gene.6364303 |
0.336 |
|
| 2006 |
Baecher-Allan C, Wolf E, Hafler DA. MHC Class II Expression Identifies Functionally Distinct Human Regulatory T Cells Journal of Immunology. 176: 4622-4631. PMID 16585553 DOI: 10.4049/Jimmunol.176.8.4622 |
0.386 |
|
| 2006 |
De Jager PL, Sawcer S, Waliszewska A, Farwell L, Wild G, Cohen A, Langelier D, Bitton A, Compston A, Hafler DA, Rioux JD. Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis. European Journal of Human Genetics : Ejhg. 14: 317-21. PMID 16391555 DOI: 10.1038/Sj.Ejhg.5201548 |
0.388 |
|
| 2006 |
Hastings W, Kent S, Kuchroo V, Hafler D. Analysis of Autoreactive T-Cells in Type I Diabetes Clinical Immunology. 119: S44. DOI: 10.1016/J.Clim.2006.04.411 |
0.345 |
|
| 2006 |
Astier A, Beriou G, Eisenhaure T, Hafler D, Hacohen N. OR.80. Identifying Regulators of Cytokine Production in Primary Human T-Cells Using a Lentiviral RNAi Library Clinical Immunology. 119. DOI: 10.1016/J.Clim.2006.04.385 |
0.391 |
|
| 2006 |
Costantino C, Ploegh H, Baecher-Allan C, Hafler D. Sa.130. HLA-DR+ CD4+ T-Cells Have the Capacity to Present Endogenous Antigen Clinical Immunology. 119: S151. DOI: 10.1016/J.Clim.2006.04.362 |
0.426 |
|
| 2006 |
De Jager P, Charles G, Wolfish C, Holland C, Alkasab T, Parker A, Roubenoff R, Khoury S, Hafler D, Weiner H. Sa.43. Role of the HLA DRB1*1501 Risk Haplotype in the Expression of Clinical and Radiographic Phenotypes of Multiple Sclerosis Clinical Immunology. 119: S120. DOI: 10.1016/J.Clim.2006.04.275 |
0.55 |
|
| 2006 |
Slavik J, Viglietta V, Bourcier K, Grinberg I, Khoury S, Hafler D. Sa.25. In Vitro Correlates of in Vivo Rapamycin Therapy in Patients with Multiple Sclerosis Clinical Immunology. 119: S113. DOI: 10.1016/J.Clim.2006.04.257 |
0.319 |
|
| 2006 |
Yang L, Anderson D, Hafler D. Sa.13. Function of TIM3 May Be Compromised in Human CD4 T-Cells of Untreated Patients with Multiple Sclerosis Clinical Immunology. 119. DOI: 10.1016/J.Clim.2006.04.245 |
0.471 |
|
| 2006 |
O'Connor K, McArdel S, Bradshaw E, Anderson D, Moore N, Brady M, Hafler D. Sa.9. Examination of the B-Cell Repertoire in the CNS of Patients with MS Clinical Immunology. 119. DOI: 10.1016/J.Clim.2006.04.241 |
0.395 |
|
| 2006 |
Kent S, Hafler D. OR.72. Enhanced Recognition of Insulin a Chain 1-15 By Expanded T-Cell Clones from Human Type 1 Diabetic (T1D) Pancreatic Draining Lymph Nodes Clinical Immunology. 119. DOI: 10.1016/J.Clim.2006.04.228 |
0.305 |
|
| 2006 |
Bander J, Baecher-Allan C, Hafler D. F.108. Further Characterizations of Human CD4+ CD25+ Regulatory T-Cells Clinical Immunology. 119. DOI: 10.1016/J.Clim.2006.04.148 |
0.364 |
|
| 2006 |
Baecher-Allan C, Ashley C, Hafler D. OR.9. Il-10 Plays a Contrasting Role in Suppression By Functionally Distinct, Dr+ and Dr− Human Natural Regulatory T-Cells Clinical Immunology. 119. DOI: 10.1016/J.Clim.2006.04.011 |
0.386 |
|
| 2005 |
Baecher-Allan CM, Hafler DA. Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+CD25+ T cells Clinical Immunology (Orlando, Fla.). 117: 192; discussion 193. PMID 16214081 DOI: 10.1016/J.Clim.2005.02.018 |
0.393 |
|
| 2005 |
Reich D, Patterson N, De Jager PL, McDonald GJ, Waliszewska A, Tandon A, Lincoln RR, DeLoa C, Fruhan SA, Cabre P, Bera O, Semana G, Kelly MA, Francis DA, Ardlie K, ... ... Hafler DA, et al. A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility. Nature Genetics. 37: 1113-8. PMID 16186815 DOI: 10.1038/Ng1646 |
0.307 |
|
| 2005 |
Kent SC, Chen Y, Clemmings SM, Viglietta V, Kenyon NS, Ricordi C, Hering B, Hafler DA. Loss of IL-4 secretion from human type 1a diabetic pancreatic draining lymph node NKT cells Journal of Immunology. 175: 4458-4464. PMID 16177088 DOI: 10.4049/Jimmunol.175.7.4458 |
0.371 |
|
| 2005 |
O'Connor KC, Appel H, Bregoli L, Call ME, Catz I, Chan JA, Moore NH, Warren KG, Wong SJ, Hafler DA, Wucherpfennig KW. Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein. Journal of Immunology (Baltimore, Md. : 1950). 175: 1974-82. PMID 16034142 DOI: 10.4049/Jimmunol.175.3.1974 |
0.765 |
|
| 2005 |
Ausubel LJ, O'Connor KC, Baecher-Allen C, Trollmo C, Kessler B, Hekking B, Merritt D, Meyer AL, Kwok B, Ploegh H, Huber BT, Hafler DA. Characterization of in vivo expanded OspA-specific human T-cell clones. Clinical Immunology (Orlando, Fla.). 115: 313-22. PMID 15893699 DOI: 10.1016/J.Clim.2005.02.015 |
0.454 |
|
| 2005 |
Kent SC, Chen Y, Bregoli L, Clemmings SM, Kenyon NS, Ricordi C, Hering BJ, Hafler DA. Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope Nature. 435: 224-228. PMID 15889096 DOI: 10.1038/Nature03625 |
0.34 |
|
| 2005 |
Hafler DA, Slavik JM, Anderson DE, O'Connor KC, De Jager P, Baecher-Allan C. Multiple sclerosis. Immunological Reviews. 204: 208-31. PMID 15790361 DOI: 10.1111/j.0105-2896.2005.00240.x |
0.37 |
|
| 2005 |
Ellmerich S, Mycko M, Takacs K, Waldner H, Wahid FN, Boyton RJ, King RH, Smith PA, Amor S, Herlihy AH, Hewitt RE, Jutton M, Price DA, Hafler DA, Kuchroo VK, et al. High incidence of spontaneous disease in an HLA-DR15 and TCR transgenic multiple sclerosis model. Journal of Immunology (Baltimore, Md. : 1950). 174: 1938-46. PMID 15699121 DOI: 10.4049/Jimmunol.174.4.1938 |
0.495 |
|
| 2005 |
Hafler DA, Kent SC, Chen Y, Bregoli L, Clemmings SM, Hering B, Kenyon NS, Ricordi C. Insulin auto-antigenicity in type 1 diabetes (Reply) Nature. 438. DOI: 10.1038/Nature04424 |
0.322 |
|
| 2004 |
Cai G, Karni A, Oliveira EM, Weiner HL, Hafler DA, Freeman GJ. PD-1 ligands, negative regulators for activation of naive, memory, and recently activated human CD4+ T cells. Cellular Immunology. 230: 89-98. PMID 15598424 DOI: 10.1016/J.Cellimm.2004.09.004 |
0.566 |
|
| 2004 |
Baecher-Allan C, Hafler DA. Suppressor T cells in human diseases Journal of Experimental Medicine. 200: 273-276. PMID 15280423 DOI: 10.1084/Jem.20040812 |
0.44 |
|
| 2004 |
Mycko MP, Waldner H, Anderson DE, Bourcier KD, Wucherpfennig KW, Kuchroo VK, Hafler DA. Cross-reactive TCR responses to self antigens presented by different MHC class II molecules. Journal of Immunology (Baltimore, Md. : 1950). 173: 1689-98. PMID 15265898 DOI: 10.4049/Jimmunol.173.3.1689 |
0.634 |
|
| 2004 |
Ellmerich S, Takacs K, Mycko M, Waldner H, Wahid F, Boyton RJ, Smith PA, Amor S, Baker D, Hafler DA, Kuchroo VK, Altmann DM. Disease-related epitope spread in a humanized T cell receptor transgenic model of multiple sclerosis. European Journal of Immunology. 34: 1839-48. PMID 15214032 DOI: 10.1002/Eji.200324044 |
0.427 |
|
| 2004 |
Khademi M, Illés Z, Gielen AW, Marta M, Takazawa N, Baecher-Allan C, Brundin L, Hannerz J, Martin C, Harris RA, Hafler DA, Kuchroo VK, Olsson T, Piehl F, Wallström E. T cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis Journal of Immunology. 172: 7169-7176. PMID 15153541 DOI: 10.4049/Jimmunol.172.11.7169 |
0.4 |
|
| 2004 |
Vijayakrishnan L, Slavik JM, Illés Z, Greenwald RJ, Rainbow D, Greve B, Peterson LB, Hafler DA, Freeman GJ, Sharpe AH, Wicker LS, Kuchroo VK. An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells. Immunity. 20: 563-75. PMID 15142525 DOI: 10.1016/S1074-7613(04)00110-4 |
0.44 |
|
| 2004 |
De Jager PL, Hafler DA. Gene expression profiling in MS: What is the clinical relevance? Lancet Neurology. 3: 269. PMID 15099539 DOI: 10.1016/S1474-4422(04)00731-8 |
0.309 |
|
| 2004 |
Hafler DA. Multiple sclerosis. The Journal of Clinical Investigation. 113: 788-94. PMID 15067307 DOI: 10.1172/JCI21357 |
0.375 |
|
| 2004 |
Viglietta V, Baecher-Allan C, Weiner HL, Hafler DA. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. The Journal of Experimental Medicine. 199: 971-9. PMID 15067033 DOI: 10.1084/Jem.20031579 |
0.659 |
|
| 2004 |
Baecher-Allan C, Viglietta V, Hafler DA. Human CD4+CD25+ regulatory T cells Seminars in Immunology. 16: 89-97. PMID 15036232 DOI: 10.1016/J.Smim.2003.12.005 |
0.429 |
|
| 2004 |
Slavik JM, Lim DG, Burakoff SJ, Hafler DA. Rapamycin-resistant Proliferation of CD8+ T Cells Correlates with p27 kip1 Down-regulation and bcl-xL Induction, and is Prevented by an Inhibitor of Phosphoinositide 3-Kinase Activity Journal of Biological Chemistry. 279: 910-919. PMID 14573608 DOI: 10.1074/Jbc.M209733200 |
0.418 |
|
| 2003 |
Baecher-Allan C, Brown JA, Freeman GJ, Hafler DA, Abbas, Bluestone, Shevach, Roncarolo. CD4+CD25+ regulatory cells from human peripheral blood express very high levels of CD25 ex vivo Novartis Foundation Symposium. 252: 67-91. PMID 14609213 DOI: 10.1002/0470871628.Ch6 |
0.349 |
|
| 2003 |
Walsh EC, Guschwan-McMahon S, Daly MJ, Hafler DA, Rioux JD. Genetic analysis of multiple sclerosis. Journal of Autoimmunity. 21: 111-6. PMID 12935779 DOI: 10.1016/S0896-8411(03)00094-5 |
0.335 |
|
| 2003 |
Lim DG, Slavik JM, Bourcier K, Smith KJ, Hafler DA. Allelic variation of MHC structure alters peptide ligands to induce atypical partial agonistic CD8+ T cell function Journal of Experimental Medicine. 198: 99-109. PMID 12847139 DOI: 10.1084/Jem.20021796 |
0.377 |
|
| 2003 |
Schmied M, Duda PW, Krieger JI, Trollmo C, Hafler DA. In vitro evidence that subcutaneous administration of glatiramer acetate induces hyporesponsive T cells in patients with multiple sclerosis Clinical Immunology. 106: 163-174. PMID 12706402 DOI: 10.1016/S1521-6616(03)00020-2 |
0.449 |
|
| 2003 |
O'Connor KC, Chitnis T, Griffin DE, Piyasirisilp S, Bar-Or A, Khoury S, Wucherpfennig KW, Hafler DA. Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactions. Journal of Neuroimmunology. 136: 140-8. PMID 12620653 DOI: 10.1016/S0165-5728(03)00002-X |
0.582 |
|
| 2003 |
Oliveira EM, Bar-Or A, Waliszewska AI, Cai G, Anderson DE, Krieger JI, Hafler DA. CTLA-4 dysregulation in the activation of myelin basic protein reactive T cells may distinguish patients with multiple sclerosis from healthy controls. Journal of Autoimmunity. 20: 71-81. PMID 12604314 DOI: 10.1016/S0896-8411(02)00106-3 |
0.513 |
|
| 2003 |
Buckle GJ, Höllsberg P, Hafler DA. Activated CD8+ T cells in secondary progressive MS secrete lymphotoxin Neurology. 60: 702-705. PMID 12601116 DOI: 10.1212/01.Wnl.0000048204.89346.30 |
0.463 |
|
| 2003 |
Cao D, Malmström V, Baecher-Allan C, Hafler D, Klareskog L, Trollmo C. Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis European Journal of Immunology. 33: 215-223. PMID 12594850 DOI: 10.1002/Immu.200390024 |
0.458 |
|
| 2003 |
Kantarci OH, Hebrink DD, Achenbach SJ, Atkinson EJ, Waliszewska A, Buckle G, McMurray CT, De Andrade M, Hafler DA, Weinshenker BG. CTLA4 is associated with susceptibility to multiple sclerosis Journal of Neuroimmunology. 134: 133-141. PMID 12507781 DOI: 10.1016/S0165-5728(02)00395-8 |
0.333 |
|
| 2002 |
Baecher-Allan C, Viglietta V, Hafler DA. Inhibition of human CD4+CD25+high regulatory T cell function Journal of Immunology. 169: 6210-6217. PMID 12444126 DOI: 10.4049/Jimmunol.169.11.6210 |
0.387 |
|
| 2002 |
Lim DG, Höllsberg P, Hafler DA. Strength of prior stimuli determines the magnitude of secondary responsiveness in CD8+ T cells Cellular Immunology. 217: 36-46. PMID 12425999 DOI: 10.1016/S0008-8749(02)00511-7 |
0.425 |
|
| 2002 |
Viglietta V, Kent SC, Orban T, Hafler DA. GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes Journal of Clinical Investigation. 109: 895-903. PMID 11927616 DOI: 10.1172/Jci14114 |
0.433 |
|
| 2002 |
Hafler DA. Degeneracy, as opposed to specificity, in immunotherapy Journal of Clinical Investigation. 109: 581-584. PMID 11877465 DOI: 10.1172/Jci15198 |
0.448 |
|
| 2001 |
Bar-Or A, Oliveira EM, Anderson DE, Krieger JI, Duddy M, O'Connor KC, Hafler DA. Immunological memory: contribution of memory B cells expressing costimulatory molecules in the resting state. Journal of Immunology (Baltimore, Md. : 1950). 167: 5669-77. PMID 11698439 DOI: 10.4049/Jimmunol.167.10.5669 |
0.318 |
|
| 2001 |
Bourcier KD, Lim DG, Ding YH, Smith KJ, Wucherpfennig K, Hafler DA. Conserved CDR3 regions in T-cell receptor (TCR) CD8+ T cells that recognize the Tax11-19/HLA-A*0201 complex in a subject infected with human T-cell leukemia virus type 1: Relationship of T-cell fine specificity and major histocompatibility complex/peptide/TCR crystal structure Journal of Virology. 75: 9836-9843. PMID 11559817 DOI: 10.1128/Jvi.75.20.9836-9843.2001 |
0.625 |
|
| 2001 |
Anderson DE, Hafler DA. Immune tolerance and the nervous system. Advances in Experimental Medicine and Biology. 490: 79-98. PMID 11505978 DOI: 10.1007/978-1-4615-1243-1_9 |
0.395 |
|
| 2001 |
Ohashi T, Yukitake M, Slavin A, Krieger J, Hafler DA. In vitro evidence that immunuaffinity-purified MOG contains immunogenic quantities of contaminating mouse IgG; techniques for producing Ig-free MOG Journal of Neuroimmunology. 118: 194-202. PMID 11498254 DOI: 10.1016/S0165-5728(01)00321-6 |
0.466 |
|
| 2001 |
Baecher-Allan C, Brown JA, Freeman GJ, Hafler DA. CD4+CD25high Regulatory Cells in Human Peripheral Blood Journal of Immunology. 167: 1245-1253. PMID 11466340 DOI: 10.4049/Jimmunol.167.3.1245 |
0.397 |
|
| 2001 |
O'Connor KC, Bar-Or A, Hafler DA. The neuroimmunology of multiple sclerosis: possible roles of T and B lymphocytes in immunopathogenesis. Journal of Clinical Immunology. 21: 81-92. PMID 11332657 DOI: 10.1023/A:1011064007686 |
0.493 |
|
| 2001 |
Trollmo C, Meyer AL, Steere AC, Hafler DA, Huber BT. Molecular mimicry in lyme arthritis demonstrated at the single cell level: LFA-1αL is a partial agonist for outer surface protein A-reactive T cells Journal of Immunology. 166: 5286-5291. PMID 11290815 DOI: 10.4049/Jimmunol.166.8.5286 |
0.425 |
|
| 2001 |
Slavik JM, Lim DG, Burakoff SJ, Hafler DA. Uncoupling p70s6 kinase activation and proliferation: Rapamycin-resistant proliferation of human CD8+ T lymphocytes1 Journal of Immunology. 166: 3201-3209. PMID 11207273 DOI: 10.4049/Jimmunol.166.5.3201 |
0.444 |
|
| 2001 |
Gausling R, Trollmo C, Hafler DA. Decreases in interleukin-4 secretion by invariant CD4-CD8-Vα24JαQ T cells in peripheral blood of patients with relapsing-remitting multiple sclerosis Clinical Immunology. 98: 11-17. PMID 11141321 DOI: 10.1006/Clim.2000.4942 |
0.45 |
|
| 2000 |
Duda PW, Krieger JI, Schmied MC, Balentine C, Hafler DA. Human and murine CD4 T cell reactivity to a complex antigen: Recognition of the synthetic random polypeptide glatiramer acetate Journal of Immunology. 165: 7300-7307. PMID 11120865 DOI: 10.4049/Jimmunol.165.12.7300 |
0.417 |
|
| 2000 |
Harrison LC, Hafler DA. Antigen-specific therapy for autoimmune disease Current Opinion in Immunology. 12: 704-711. PMID 11102776 DOI: 10.1016/S0952-7915(00)00166-7 |
0.379 |
|
| 2000 |
Lim DG, Bourcier KB, Freeman GJ, Hafler DA. Examination of CD8+ t cell function in humans using MHC class I tetramers: Similar cytotoxicity but variable proliferation and cytokine production among different clonal CD8+ T cells specific to a single viral epitope Journal of Immunology. 165: 6214-6220. PMID 11086055 DOI: 10.4049/Jimmunol.165.11.6214 |
0.467 |
|
| 2000 |
Meyer AL, Trollmo C, Crawford F, Marrack P, Steere AC, Huber BT, Kappler J, Hafler DA. Direct enumeration of Borrelia-reactive CD4 T cells ex vivo by using MHC class II tetramers. Proceedings of the National Academy of Sciences of the United States of America. 97: 11433-8. PMID 11005833 DOI: 10.1073/Pnas.190335897 |
0.454 |
|
| 2000 |
Kiefer R, Dangond F, Mueller M, Toyka KV, Hafler DA, Hartung HP. Enhanced B7 costimulatory molecule expression in inflammatory human sural nerve biopsies Journal of Neurology Neurosurgery and Psychiatry. 69: 362-368. PMID 10945811 DOI: 10.1046/J.1529-8027.2001.01008-15.X |
0.351 |
|
| 2000 |
Kipp B, Bar-Or A, Gausling R, Oliveira EML, Fruhan SA, Stuart WH, Hafler DA. A novel population of B7-1+ T cells producing intracellular IL-4 is decreased in patients with multiple sclerosis European Journal of Immunology. 30: 2092-2100. PMID 10940899 DOI: 10.1002/1521-4141(200007)30:7<2092::Aid-Immu2092>3.0.Co;2-7 |
0.482 |
|
| 2000 |
Hunter SF, Hafler DA. Ubiquitous pathogens: Links between infection and autoimmunity in MS? Neurology. 55: 164-165. PMID 10908883 DOI: 10.1212/Wnl.55.2.164 |
0.385 |
|
| 2000 |
Wilson SB, Kent SC, Horton HF, Hill AA, Bollyky PL, Hafler DA, Strominger JL, Byrne MC. Multiple differences in gene expression in regulatory Valpha 24Jalpha Q T cells from identical twins discordant for type I diabetes. Proceedings of the National Academy of Sciences of the United States of America. 97: 7411-6. PMID 10840051 DOI: 10.1073/Pnas.120161297 |
0.568 |
|
| 2000 |
Duda PW, Schmied MC, Cook SL, Krieger JI, Hafler DA. Glatiramer acetate (Copaxone®) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis Journal of Clinical Investigation. 105: 967-976. PMID 10749576 DOI: 10.1172/Jci8970 |
0.5 |
|
| 2000 |
Anderson DE, Bieganowska KD, Bar-Or A, Oliveira EM, Carreno B, Collins M, Hafler DA. Paradoxical inhibition of T-cell function in response to CTLA-4 blockade; heterogeneity within the human T-cell population. Nature Medicine. 6: 211-4. PMID 10655112 DOI: 10.1038/72323 |
0.471 |
|
| 1999 |
Bar-Or A, Oliveira EM, Anderson DE, Hafler DA. Molecular pathogenesis of multiple sclerosis. Journal of Neuroimmunology. 100: 252-9. PMID 10695735 DOI: 10.1016/S0165-5728(99)00193-9 |
0.463 |
|
| 1999 |
Anderson DE, Sharpe AH, Hafler DA. The B7-CD28/CTLA-4 costimulatory pathways in autoimmune disease of the central nervous system. Current Opinion in Immunology. 11: 677-83. PMID 10631554 DOI: 10.1016/S0952-7915(99)00036-9 |
0.434 |
|
| 1999 |
Hohol MJ, Olek MJ, Orav EJ, Stazzone L, Hafler DA, Khoury SJ, Dawson DM, Weiner HL. Treatment of progressive multiple sclerosis with pulse cyclophosphamide/methylprednisolone: response to therapy is linked to the duration of progressive disease. Multiple Sclerosis (Houndmills, Basingstoke, England). 5: 403-9. PMID 10618696 DOI: 10.1177/135245859900500I606 |
0.583 |
|
| 1999 |
Kent SC, Hafler DA, Strominger JL, Wilson SB. Noncanonical Valpha24JalphaQ T cells with conservative alpha chain CDR3 region amino acid substitutions are restricted by CD1d. Human Immunology. 60: 1080-9. PMID 10600006 DOI: 10.1016/S0198-8859(99)00109-3 |
0.522 |
|
| 1999 |
Hafler DA. The distinction blurs between an autoimmune versus microbial hypothesis in multiple sclerosis Journal of Clinical Investigation. 104: 527-529. PMID 10487765 DOI: 10.1172/Jci8193 |
0.497 |
|
| 1999 |
Milner JD, Kent SC, Ashley TA, Wilson SB, Strominger JL, Hafler DA. Differential responses of invariant V alpha 24J alpha Q T cells and MHC class II-restricted CD4+ T cells to dexamethasone. Journal of Immunology (Baltimore, Md. : 1950). 163: 2522-9. PMID 10452989 |
0.499 |
|
| 1999 |
She JX, Ellis TM, Wilson SB, Wasserfall CH, Marron M, Reimsneider S, Kent SC, Hafler DA, Neuberg DS, Muir A, Strominger JL, Atkinson MA. Heterophile antibodies segregate in families and are associated with protection from type 1 diabetes. Proceedings of the National Academy of Sciences of the United States of America. 96: 8116-9. PMID 10393957 DOI: 10.1073/pnas.96.14.8116 |
0.359 |
|
| 1999 |
Pohl-Koppe A, Logigian EL, Steere AC, Hafler DA. Cross-reactivity of Borrelia burgdorferi and myelin basic protein-specific T cells is not observed in borrelial encephalomyelitis. Cellular Immunology. 194: 118-123. PMID 10357888 DOI: 10.1006/Cimm.1999.1495 |
0.505 |
|
| 1999 |
Semana G, Gausling R, Jackson RA, Hafler DA. T cell autoreactivity to proinsulin epitopes in diabetic patients and healthy subjects. Journal of Autoimmunity. 12: 259-67. PMID 10330297 DOI: 10.1006/Jaut.1999.0282 |
0.365 |
|
| 1999 |
Smith D, Buckle GJ, Hafler DA, Frank DA, Höllsberg P. HTLV-I-infected T cells evade the antiproliferative action of IFN-β Virology. 257: 314-321. PMID 10329542 DOI: 10.1006/Viro.1999.9679 |
0.439 |
|
| 1999 |
Ausubel LJ, Bieganowska KD, Hafler DA. Cross-reactivity of T-cell clones specific for altered peptide ligands of myelin basic protein. Cellular Immunology. 193: 99-107. PMID 10202117 DOI: 10.1006/Cimm.1998.1447 |
0.462 |
|
| 1999 |
Wilson SB, Kent SC, Patton KT, Orban T, Jackson RA, Exley M, Porcelli S, Schatz DA, Atkinson MA, Balk SP, Strominger JL, Hafler DA. Erratum: Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes Nature. 399: 84-84. DOI: 10.1038/20007 |
0.492 |
|
| 1998 |
Pohl-Koppe A, Burchett SK, Thiele EA, Hafler DA. Myelin basic protein reactive Th2 T cells are found in acute disseminated encephalomyelitis Journal of Neuroimmunology. 91: 19-27. PMID 9846815 DOI: 10.1016/S0165-5728(98)00125-8 |
0.445 |
|
| 1998 |
Windhagen A, Anderson DE, Carrizosa A, Balashov K, Weiner HL, Hafler DA. Cytokine secretion of myelin basic protein reactive T cells in patients with multiple sclerosis. Journal of Neuroimmunology. 91: 1-9. PMID 9846813 DOI: 10.1016/S0165-5728(98)00086-1 |
0.664 |
|
| 1998 |
Martin R, Ruddle NH, Reingold S, Hafler DA. T helper cell differentiation in multiple sclerosis and autoimmunity. Immunology Today. 19: 495-8. PMID 9818541 DOI: 10.1016/S0167-5699(98)01345-0 |
0.494 |
|
| 1998 |
Takashima H, Smith DR, Fukaura H, Khoury SJ, Hafler DA, Weiner HL. Pulse cyclophosphamide plus methylprednisolone induces myelin-antigen-specific IL-4-secreting T cells in multiple sclerosis patients. Clinical Immunology and Immunopathology. 88: 28-34. PMID 9683547 DOI: 10.1006/Clin.1998.4558 |
0.669 |
|
| 1998 |
Scholz C, Patton KT, Anderson DE, Freeman GJ, Hafler DA. Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation Journal of Immunology. 160: 1532-1538. PMID 9570577 |
0.433 |
|
| 1998 |
Mandelboim O, Kent S, Davis DM, Wilson SB, Okazaki T, Jackson R, Hafler D, Strominger JL. Natural killer activating receptors trigger interferon gamma secretion from T cells and natural killer cells. Proceedings of the National Academy of Sciences of the United States of America. 95: 3798-803. PMID 9520447 DOI: 10.1073/Pnas.95.7.3798 |
0.585 |
|
| 1998 |
Dangond F, Hafler DA, Tong JK, Randall J, Kojima R, Utku N, Gullans SR. Differential display cloning of a novel human histone deacetylase (HDAC3) cDNA from PHA-activated immune cells. Biochemical and Biophysical Research Communications. 242: 648-52. PMID 9464271 DOI: 10.1006/Bbrc.1997.8033 |
0.36 |
|
| 1998 |
Wilson SB, Kent SC, Patton KT, Orban T, Jackson RA, Exley M, Porcelli S, Schatz DA, Atkinson MA, Balk SP, Strominger JL, Hafler DA. Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes. Nature. 391: 177-81. PMID 9428763 DOI: 10.1038/34419 |
0.526 |
|
| 1998 |
Duda PW, Krieger JI, Hafler DA. In vitro analysis of T-cell responses to Copaxone® Journal of Neuroimmunology. 90: 96. DOI: 10.1016/S0165-5728(98)91756-8 |
0.416 |
|
| 1998 |
Buckle GJ, Batra V, Hafler DA, Hollsberg P. Increased expression of CDIIb (mac-1) on CD8+ T cells in patients with HAM/TSP Journal of Neuroimmunology. 90: 64. DOI: 10.1016/S0165-5728(98)91559-4 |
0.42 |
|
| 1998 |
Bieganowska K, Anderson DE, Bar-Or A, Hafler DA. Effect of CD28/CTLA4 signaling on function of MBP reactive T cells Journal of Neuroimmunology. 90: 15. DOI: 10.1016/S0165-5728(98)91267-X |
0.405 |
|
| 1998 |
Bar-Or A, Anderson DE, Bieganowska K, Hafler DA. CTLA4 blockade enhances B7-2 dependent Th-2 cytokine production from human MBP-reactive T-cells Journal of Neuroimmunology. 90: 14. DOI: 10.1016/S0165-5728(98)91263-2 |
0.408 |
|
| 1998 |
Anderson DE, Bieganowska K, Bar-Or A, Hafler DA. CTLA4 engagement can have both positive and negative effects on human T cell activation Journal of Neuroimmunology. 90: 14. DOI: 10.1016/S0165-5728(98)91262-0 |
0.383 |
|
| 1997 |
Hafler DA, Kent SC, Pietrusewicz MJ, Khoury SJ, Weiner HL, Fukaura H. Oral administration of myelin induces antigen-specific TGF-beta 1 secreting T cells in patients with multiple sclerosis. Annals of the New York Academy of Sciences. 835: 120-31. PMID 9616767 DOI: 10.1111/J.1749-6632.1997.Tb48623.X |
0.674 |
|
| 1997 |
Smith DR, Balashov KE, Hafler DA, Khoury SJ, Weiner HL. Immune deviation following pulse cyclophosphamide/methylprednisolone treatment of multiple sclerosis: increased interleukin-4 production and associated eosinophilia. Annals of Neurology. 42: 313-8. PMID 9307252 DOI: 10.1002/Ana.410420307 |
0.603 |
|
| 1997 |
Anderson DE, Ausubel LJ, Krieger J, Höllsberg P, Freeman GJ, Hafler DA. Weak peptide agonists reveal functional differences in B7-1 and B7-2 costimulation of human T cell clones. Journal of Immunology (Baltimore, Md. : 1950). 159: 1669-75. PMID 9257827 |
0.304 |
|
| 1997 |
Kent SC, Fukaura H, Pietrusewicz MJ, Khoury SJ, Weiner HL, Hafler DA. Oral administration of myelin induces antigen-specific TGF-beta 1-secreting T cells in multiple sclerosis patients. Annals of the New York Academy of Sciences. 815: 412-22. PMID 9186687 DOI: 10.1111/J.1749-6632.1997.Tb52092.X |
0.63 |
|
| 1997 |
Dangond F, Windhagen A, Groves CJ, Hafler DA. Constitutive expression of costimulatory molecules by human microglia and its relevance to CNS autoimmunity. Journal of Neuroimmunology. 76: 132-138. PMID 9184642 DOI: 10.1016/S0165-5728(97)00043-X |
0.455 |
|
| 1997 |
Nussenblatt RB, Gery I, Weiner HL, Ferris FL, Shiloach J, Remaley N, Perry C, Caspi RR, Hafler DA, Foster CS, Whitcup SM. Treatment of uveitis by oral administration of retinal antigens: results of a phase I/II randomized masked trial. American Journal of Ophthalmology. 123: 583-92. PMID 9152063 DOI: 10.1016/S0002-9394(14)71070-0 |
0.535 |
|
| 1997 |
Bieganowska KD, Ausubel LJ, Modabber Y, Slovik E, Messersmith W, Hafler DA. Direct ex vivo analysis of activated, Fas-sensitive autoreactive T cells in human autoimmune disease. The Journal of Experimental Medicine. 185: 1585-94. PMID 9151896 DOI: 10.1084/Jem.185.9.1585 |
0.493 |
|
| 1997 |
Richardson JH, Höllsberg P, Windhagen A, Child LA, Hafler DA, Lever AML. Variable immortalizing potential and frequent virus latency in blood- derived T-cell clones infected with human T-cell leukemia virus type I Blood. 89: 3303-3314. PMID 9129036 DOI: 10.1182/Blood.V89.9.3303 |
0.413 |
|
| 1997 |
Greenfield EA, Howard E, Paradis T, Nguyen K, Benazzo F, McLean P, Höllsberg P, Davis G, Hafler DA, Sharpe AH, Freeman GJ, Kuchroo VK. B7.2 Expressed by T Cells Does Not Induce CD28-Mediated Costimulatory Activity but Retains CTLA4 Binding: Implications for Induction of Antitumor Immunity to T Cell Tumors Journal of Immunology. 158: 2025-2034. PMID 9036945 |
0.323 |
|
| 1997 |
Balashov KE, Smith DR, Khoury SJ, Hafler DA, Weiner HL. Increased interleukin 12 production in progressive multiple sclerosis: induction by activated CD4+ T cells via CD40 ligand. Proceedings of the National Academy of Sciences of the United States of America. 94: 599-603. PMID 9012830 DOI: 10.1073/Pnas.94.2.599 |
0.676 |
|
| 1997 |
Scholz C, Hafler DA, Höllsberg P. Downregulation of IL-10 secretion and enhanced antigen-presenting abilities following HTLV-I infection of T cells. Journal of Neuroscience Research. 45: 786-94. PMID 8892090 DOI: 10.1002/(SICI)1097-4547(19960915)45:6<786::AID-JNR15>3.0.CO;2-U |
0.349 |
|
| 1997 |
Hafler DA, Saadeh MG, Kuchroo VK, Milford E, Steinman L. TCR usage in human and experimental demyelinating disease. Immunology Today. 17: 152-9. PMID 8871344 DOI: 10.1016/0167-5699(96)80611-6 |
0.479 |
|
| 1996 |
Ausubel LJ, Kwan CK, Sette A, Kuchroo V, Hafler DA. Complementary mutations in an antigenic peptide allow for crossreactivity of autoreactive T-cell clones. Proceedings of the National Academy of Sciences of the United States of America. 93: 15317-22. PMID 8986809 DOI: 10.1073/Pnas.93.26.15317 |
0.398 |
|
| 1996 |
Höllsberg P, Batra V, Dressel A, Hafler DA. Induction of Anergy in CD8 T Cells by B Cell Presentation of Antigen Journal of Immunology. 157: 5269-5276. PMID 8955172 |
0.336 |
|
| 1996 |
Windhagen A, Nicholson LB, Weiner HL, Kuchroo VK, Hafler DA. Role of Th1 and Th2 cells in neurologic disorders. Chemical Immunology. 63: 171-86. PMID 8934837 DOI: 10.1159/000319485 |
0.537 |
|
| 1996 |
Scholz C, Freeman GJ, Greenfield EA, Hafler DA, Höllsberg P. Activation of Human T Cell Lymphotropic Virus Type I-Infected T Cells Is Independent of B7 Costimulation Journal of Immunology. 157: 2932-2938. PMID 8816399 |
0.305 |
|
| 1996 |
Rothenberg ME, Weber WE, Longtine JA, Hafler DA. Cytotoxic gamma delta I lymphocytes associated with an Epstein-Barr virus-induced posttransplantation lymphoproliferative disorder. Clinical Immunology and Immunopathology. 80: 266-72. PMID 8811046 DOI: 10.1006/Clin.1996.0122 |
0.448 |
|
| 1996 |
Buckle GJ, Hafler DA, Höllsberg P. HTLV-I-induced T-cell activation. Journal of Acquired Immune Deficiency Syndromes. 13. PMID 8797712 DOI: 10.1097/00042560-199600001-00018 |
0.454 |
|
| 1996 |
Fukaura H, Kent SC, Pietrusewicz MJ, Khoury SJ, Weiner HL, Hafler DA. Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients. The Journal of Clinical Investigation. 98: 70-7. PMID 8690806 DOI: 10.1172/Jci118779 |
0.672 |
|
| 1996 |
Matsui M, Hafler DA, Weiner HL. Pilot study of oral tolerance to keyhole limpet hemocyanin in humans: down-regulation of KLH-reactive precursor-cell frequency. Annals of the New York Academy of Sciences. 778: 398-404. PMID 8611003 DOI: 10.1111/J.1749-6632.1996.Tb21156.X |
0.544 |
|
| 1996 |
Fukaura H, Kent SC, Pietrusewicz MJ, Khoury SJ, Weiner HL, Hafler DA. Antigen-specific TGF-beta1 secretion with bovine myelin oral tolerization in multiple sclerosis. Annals of the New York Academy of Sciences. 778: 251-7. PMID 8610978 DOI: 10.1111/J.1749-6632.1996.Tb21133.X |
0.671 |
|
| 1996 |
Hohol MJ, Khoury SJ, Cook SL, Orav EJ, Hafler DA, Weiner HL. Three-year open protocol continuation study of oral tolerization with myelin antigens in multiple sclerosis and design of a phase III pivotal trial. Annals of the New York Academy of Sciences. 778: 243-50. PMID 8610977 DOI: 10.1111/J.1749-6632.1996.Tb21132.X |
0.548 |
|
| 1996 |
Pohi-Koppe A, Burchett SK, Hafler DA. Functional Characterization of Autoreactive T-cells in Acute Disseminated Encephalomyelitis 199 Pediatric Research. 40: 548-548. DOI: 10.1203/00006450-199609000-00222 |
0.397 |
|
| 1996 |
Weiner HL, Balashov KE, Smith DR, Khoury SJ, Hafler DA. Increased IL-12 production in progressive multiple sclerosis: Induction by activated CD4+ T cells via CD40 ligand Multiple Sclerosis Journal. 2: 253-253. DOI: 10.1177/135245859600200519 |
0.61 |
|
| 1995 |
Dangond F, Daza JS, Rosania A, Quin MJ, Zaninovic V, Chaplin B, Marlink R, Hafler DA. Tropical spastic paraparesis on the Caribbean coast of Colombia. American Journal of Tropical Medicine and Hygiene. 52: 155-158. PMID 7872443 DOI: 10.4269/Ajtmh.1995.52.155 |
0.353 |
|
| 1995 |
Hafler DA, Weiner HL. Antigen-specific immunosuppression: oral tolerance for the treatment of autoimmune disease. Chemical Immunology. 60: 126-49. PMID 7857525 DOI: 10.1159/000423974 |
0.56 |
|
| 1995 |
Höllsberg P, Hafler DA. What is the pathogenesis of human T-cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis? Annals of Neurology. 37: 143-145. PMID 7847855 DOI: 10.1002/Ana.410370203 |
0.379 |
|
| 1995 |
Hafler DA, Weiner HL. Antigen specific therapies for the treatment of autoimmune diseases. Agents and Actions. Supplements. 47: 59-77. PMID 7785504 DOI: 10.1007/978-3-0348-7343-7_5 |
0.496 |
|
| 1995 |
Balashov KE, Khoury SJ, Hafler DA, Weiner HL. Inhibition of T cell responses by activated human CD8+ T cells is mediated by interferon-gamma and is defective in chronic progressive multiple sclerosis. The Journal of Clinical Investigation. 95: 2711-9. PMID 7769110 DOI: 10.1172/Jci117973 |
0.659 |
|
| 1995 |
Weiner HL, Hohol MJ, Khoury SJ, Dawson DM, Hafler DA. Therapy for multiple sclerosis. Neurologic Clinics. 13: 173-96. PMID 7739502 DOI: 10.1016/S0733-8619(18)30066-5 |
0.615 |
|
| 1995 |
Höllsberg P, Weber WE, Dangond F, Batra V, Sette A, Hafler DA. Differential activation of proliferation and cytotoxicity in human T-cell lymphotropic virus type I Tax-specific CD8 T cells by an altered peptide ligand. Proceedings of the National Academy of Sciences of the United States of America. 92: 4036-40. PMID 7732026 DOI: 10.1073/Pnas.92.9.4036 |
0.449 |
|
| 1995 |
Hafler DA, Weiner HL. Immunologic mechanisms and therapy in multiple sclerosis. Immunological Reviews. 144: 75-107. PMID 7590822 DOI: 10.1111/J.1600-065X.1995.Tb00066.X |
0.548 |
|
| 1995 |
Wucherpfennig KW, Hafler DA, Strominger JL. Structure of human T-cell receptors specific for an immunodominant myelin basic protein peptide: positioning of T-cell receptors on HLA-DR2/peptide complexes. Proceedings of the National Academy of Sciences of the United States of America. 92: 8896-900. PMID 7568039 DOI: 10.1073/Pnas.92.19.8896 |
0.633 |
|
| 1995 |
Wucherpfennig KW, Hafler DA. A review of T-cell receptors in multiple sclerosis: clonal expansion and persistence of human T-cells specific for an immunodominant myelin basic protein peptide. Annals of the New York Academy of Sciences. 756: 241-58. PMID 7544075 DOI: 10.1111/J.1749-6632.1995.Tb44522.X |
0.642 |
|
| 1995 |
McLaurin J, Hafler DA, Antel JP. Reactivity of normal T-cell lines to MBP isolated from normal and multiple sclerosis white matter Journal of the Neurological Sciences. 128: 205-211. PMID 7537795 DOI: 10.1016/0022-510X(94)00224-C |
0.484 |
|
| 1995 |
Windhagen A, Schooz C, Höllsberg P, Fukaura H, Sette A, Hafler DA. Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand Immunity. 2: 373-380. PMID 7536622 DOI: 10.1016/1074-7613(95)90145-0 |
0.385 |
|
| 1995 |
Windhagen A, Newcombe J, Dangond F, Strand C, Woodroofe MN, Cuzner ML, Hafler DA. Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions. The Journal of Experimental Medicine. 182: 1985-96. PMID 7500044 DOI: 10.1084/Jem.182.6.1985 |
0.5 |
|
| 1995 |
Hafler DA, Weiner HL. Antigen-specific therapies for the treatment of autoimmune diseases. Springer Seminars in Immunopathology. 17: 61-76. PMID 7482227 DOI: 10.1007/Bf00194100 |
0.608 |
|
| 1995 |
Weiner HL, Guttman CR, Khoury SJ, Hohol MJ, Hafler DA, Orav EJ, Hsu L, Ahn SS, Kikinis R, Jolesz FA. Correlation of Magnetic Resonance Imaging With Immune and Clinical Measures in 45 MS Patients Receiving 20 to 24 MRI Scans Each Over a 1 -Year Period: 1 Neurology. 45: 1416-1416. DOI: 10.1212/Wnl.45.7.1416 |
0.536 |
|
| 1995 |
Weiner HL, Hohol MJ, Fukaura H, Kent S, Orav J, Khoury SJ, Hafler DA. Treatment of multiple sclerosis and other autoimmune diseases by oral tolerance to autoantigens Journal of Neuroimmunology. 56: 14-14. DOI: 10.1016/0165-5728(95)98898-L |
0.58 |
|
| 1994 |
Kuchroo VK, Collins M, al-Sabbagh A, Sobel RA, Whitters MJ, Zamvil SS, Dorf ME, Hafler DA, Seidman JG, Weiner HL. T cell receptor (TCR) usage determines disease susceptibility in experimental autoimmune encephalomyelitis: studies with TCR V beta 8.2 transgenic mice. The Journal of Experimental Medicine. 179: 1659-64. PMID 8163944 DOI: 10.1084/Jem.179.5.1659 |
0.646 |
|
| 1994 |
Weiner HL, Friedman A, Miller A, Khoury SJ, al-Sabbagh A, Santos L, Sayegh M, Nussenblatt RB, Trentham DE, Hafler DA. Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annual Review of Immunology. 12: 809-37. PMID 8011298 DOI: 10.1146/Annurev.Iy.12.040194.004113 |
0.607 |
|
| 1994 |
LaSalle JM, Hafler DA. T cell anergy. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 8: 601-8. PMID 8005388 DOI: 10.1096/Fasebj.8.9.8005388 |
0.455 |
|
| 1994 |
Chung S, Wucherpfennig KW, Friedman SM, Hafler DA, Strominger JL. Functional three-domain single-chain T-cell receptors. Proceedings of the National Academy of Sciences of the United States of America. 91: 12654-8. PMID 7809095 DOI: 10.1073/Pnas.91.26.12654 |
0.62 |
|
| 1994 |
Chen Y, Kuchroo VK, Inobe J, Hafler DA, Weiner HL. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science (New York, N.Y.). 265: 1237-40. PMID 7520605 DOI: 10.1126/Science.7520605 |
0.671 |
|
| 1994 |
Wucherpfennig KW, Zhang J, Witek C, Matsui M, Modabber Y, Ota K, Hafler DA. Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. Journal of Immunology (Baltimore, Md. : 1950). 152: 5581-92. PMID 7514641 |
0.58 |
|
| 1994 |
Zhang J, Markovic-Plese S, Lacet B, Raus J, Weiner HL, Hafler DA. Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. The Journal of Experimental Medicine. 179: 973-84. PMID 7509366 DOI: 10.1084/Jem.179.3.973 |
0.692 |
|
| 1994 |
Wucherpfennig KW, Sette A, Southwood S, Oseroff C, Matsui M, Strominger JL, Hafler DA. Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones. The Journal of Experimental Medicine. 179: 279-90. PMID 7505801 DOI: 10.1084/Jem.179.1.279 |
0.668 |
|
| 1994 |
Weiner HL, Orav EJ, Hafler DA, Dawson DM. Cyclophosphamide and MS‐RRR Neurology. 44: 580-580. DOI: 10.1212/Wnl.44.3_Part_1.580 |
0.493 |
|
| 1994 |
Zhang JW, Medaer R, Stinissen P, Hafler D, Raus J. In vivo clonal depletion of human myelin basic protein-reactive T cells by T cell vaccination Journal of Neuroimmunology. 54: 208. DOI: 10.1016/0165-5728(94)90597-5 |
0.417 |
|
| 1994 |
Windhagen A, Scholz C, Fukaura H, Sette A, Hafler DA. Switch of autoreactive human T cell clones from a TH2 to a TGFβ1 secreting phenotype with low affinity T-cell receptor stimulating peptide/MHC complex Journal of Neuroimmunology. 54: 206. DOI: 10.1016/0165-5728(94)90586-X |
0.42 |
|
| 1994 |
Markovic-Plese S, Fukoara H, Al-Sabbagh A, Sette A, Kuchroo VK, Hafler DA. T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans Journal of Neuroimmunology. 54: 179. DOI: 10.1016/0165-5728(94)90423-5 |
0.412 |
|
| 1994 |
Höllsberg P, Weber W, Dangond F, Batra V, Sette A, Hafler DA. AbstractDifferential activation of cytolysis and proliferation in HTLV-I tax-reactive CD8 T cells by a single amino acid substitution in a T cell receptor contact residue of the peptide antigen Journal of Neuroimmunology. 54: 168. DOI: 10.1016/0165-5728(94)90360-3 |
0.418 |
|
| 1993 |
Hollsberg P, Hafler DA. Seminars in medicine of the Beth Israel Hospital, Boston. Pathogenesis of diseases induced by human lymphotropic virus type I infection. The New England Journal of Medicine. 328: 1173-1182. PMID 8455685 DOI: 10.1056/Nejm199304223281608 |
0.428 |
|
| 1993 |
Weiner HL, Mackin GA, Orav EJ, Hafler DA, Dawson DM, LaPierre Y, Herndon R, Lehrich JR, Hauser SL, Turel A. Intermittent cyclophosphamide pulse therapy in progressive multiple sclerosis: final report of the Northeast Cooperative Multiple Sclerosis Treatment Group. Neurology. 43: 910-8. PMID 8388090 DOI: 10.1212/Wnl.43.5.910 |
0.556 |
|
| 1993 |
Trentham DE, Dynesius-Trentham RA, Orav EJ, Combitchi D, Lorenzo C, Sewell KL, Hafler DA, Weiner HL. Effects of oral administration of type II collagen on rheumatoid arthritis. Science (New York, N.Y.). 261: 1727-30. PMID 8378772 DOI: 10.1126/Science.8378772 |
0.572 |
|
| 1993 |
Höllsberg P, Melinek J, Benjamin D, Hafler DA. Increased Protein Kinase C Activity in Human Memory T Cells Cellular Immunology. 149: 170-179. PMID 8099849 DOI: 10.1006/Cimm.1993.1145 |
0.413 |
|
| 1993 |
Wucherpfennig KW, Liao YJ, Prendergast M, Prendergast J, Hafler DA, Strominger JL. Human fetal liver gamma/delta T cells predominantly use unusual rearrangements of the T cell receptor delta and gamma loci expressed on both CD4+CD8- and CD4-CD8- gamma/delta T cells. The Journal of Experimental Medicine. 177: 425-32. PMID 8093893 DOI: 10.1084/Jem.177.2.425 |
0.669 |
|
| 1993 |
Zhang J, Medaer R, Stinissen P, Hafler D, Raus J. MHC-restricted depletion of human myelin basic protein-reactive T cells by T cell vaccination Science. 261: 1451-1454. PMID 7690157 DOI: 10.1126/Science.7690157 |
0.461 |
|
| 1993 |
Hafler DA, Zhang JW, LaSalle J, Donnelly C, Weiner HL, Wucherpfeffnig K. The development of antigen specific therapies for autoimmune diseases; investigations in multiple sclerosis as a paradigm for rheumatoid arthritis. Clinical and Experimental Rheumatology. 11: S39-40. PMID 7686832 |
0.421 |
|
| 1993 |
Oettinger HF, al-Sabbagh A, Jingwu Z, LaSalle JM, Weiner HL, Hafler DA. Biological activity of recombinant human myelin basic protein. Journal of Neuroimmunology. 44: 157-62. PMID 7685037 DOI: 10.1016/0165-5728(93)90037-Y |
0.577 |
|
| 1993 |
Weiner HL, Mackin GA, Matsui M, Orav EJ, Khoury SJ, Dawson DM, Hafler DA. Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis. Science (New York, N.Y.). 259: 1321-4. PMID 7680493 DOI: 10.1126/Science.7680493 |
0.633 |
|
| 1992 |
Wucherpfennig KW, Höllsberg P, Richardson JH, Benjamin D, Hafler DA. T-cell activation by autologous human T-cell leukemia virus type I-infected T-cell clones. Proceedings of the National Academy of Sciences of the United States of America. 89: 2110-4. PMID 1549569 DOI: 10.1073/Pnas.89.6.2110 |
0.65 |
|
| 1992 |
Hafler DA, Cohen I, Benjamin DS, Weiner HL. T cell vaccination in multiple sclerosis: a preliminary report. Clinical Immunology and Immunopathology. 62: 307-13. PMID 1541056 DOI: 10.1016/0090-1229(92)90108-Z |
0.687 |
|
| 1992 |
LaSalle JM, Tolentino PJ, Freeman GJ, Nadler LM, Hafler DA. Early signaling defects in human T cells anergized by T cell presentation of autoantigen. The Journal of Experimental Medicine. 176: 177-86. PMID 1535366 DOI: 10.1084/Jem.176.1.177 |
0.467 |
|
| 1992 |
Wucherpfennig KW, Newcombe J, Li H, Keddy C, Cuzner ML, Hafler DA. Gamma delta T-cell receptor repertoire in acute multiple sclerosis lesions. Proceedings of the National Academy of Sciences of the United States of America. 89: 4588-92. PMID 1374907 DOI: 10.1073/Pnas.89.10.4588 |
0.655 |
|
| 1992 |
Höllsberg P, Wucherpfennig KW, Ausubel LJ, Calvo V, Bierer BE, Hafler DA. Characterization of HTLV-I in vivo infected T cell clones. IL-2-independent growth of nontransformed T cells. Journal of Immunology (Baltimore, Md. : 1950). 148: 3256-63. PMID 1374452 |
0.561 |
|
| 1992 |
Wucherpfennig KW, Newcombe J, Li H, Keddy C, Cuzner ML, Hafler DA. T cell receptor V alpha-V beta repertoire and cytokine gene expression in active multiple sclerosis lesions. The Journal of Experimental Medicine. 175: 993-1002. PMID 1348083 DOI: 10.1084/Jem.175.4.993 |
0.602 |
|
| 1992 |
Zhang J, Weiner HL, Hafler DA. Autoreactive T cells in multiple sclerosis. International Reviews of Immunology. 9: 183-201. PMID 1285060 DOI: 10.3109/08830189209061790 |
0.648 |
|
| 1992 |
Miller A, Hafler DA, Weiner HL. Immunotherapy in autoimmune diseases Current Biology. 2: 74. DOI: 10.1016/0960-9822(92)90205-O |
0.493 |
|
| 1991 |
Miller A, Hafler DA, Weiner HL. Tolerance and suppressor mechanisms in experimental autoimmune encephalomyelitis: implications for immunotherapy of human autoimmune diseases. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 5: 2560-6. PMID 1868980 DOI: 10.1096/Fasebj.5.11.1868980 |
0.591 |
|
| 1991 |
Lee SJ, Wucherpfennig KW, Brod SA, Benjamin D, Weiner HL, Hafler DA. Common T-cell receptor V beta usage in oligoclonal T lymphocytes derived from cerebrospinal fluid and blood of patients with multiple sclerosis. Annals of Neurology. 29: 33-40. PMID 1847614 DOI: 10.1002/Ana.410290109 |
0.736 |
|
| 1991 |
LaSalle JM, Hafler DA. The coexpression of CD45RA and CD45RO isoforms on T cells during the S/G2/M stages of cell cycle. Cellular Immunology. 138: 197-206. PMID 1833074 DOI: 10.1016/0008-8749(91)90144-Z |
0.439 |
|
| 1991 |
Miller A, Hafler DA, Weiner HL. Immunotherapy in autoimmune diseases. Current Opinion in Immunology. 3: 936-40. PMID 1793539 DOI: 10.1016/0960-9822(92)90205-O |
0.617 |
|
| 1991 |
Hafler DA, Matsui M, Wucherpfennig KW, Ota K, Weiner HL. The potential of restricted T cell recognition of myelin basic protein epitopes in the therapy of multiple sclerosis. Annals of the New York Academy of Sciences. 636: 251-65. PMID 1724362 DOI: 10.1111/J.1749-6632.1991.Tb33456.X |
0.721 |
|
| 1991 |
Wucherpfennig KW, Weiner HL, Hafler DA. T-cell recognition of myelin basic protein. Immunology Today. 12: 277-82. PMID 1716903 DOI: 10.1016/0167-5699(91)90126-E |
0.708 |
|
| 1991 |
Brod SA, al-Sabbagh A, Sobel RA, Hafler DA, Weiner HL. Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin antigens: IV. Suppression of chronic relapsing disease in the Lewis rat and strain 13 guinea pig. Annals of Neurology. 29: 615-22. PMID 1716432 DOI: 10.1002/Ana.410290608 |
0.58 |
|
| 1991 |
Khatri B, Mcquillen M, Hoffmann R, Weiner H, Hauser S, Dawson D, Hafler D, Mackin G, Orav EJ, Currier R, Haerer A, Files J, Morrison F. Cyclophosphamide and plasma exchange in multiple sclerosis. The Lancet. 337: 1540-1541. PMID 1675382 DOI: 10.1016/0140-6736(91)93226-Y |
0.476 |
|
| 1991 |
Hafler DA, Orav J, Gertz R, Stazzone L, Weiner HL. Immunologic effects of cyclophosphamide/ACTH in patients with chronic progressive multiple sclerosis. Journal of Neuroimmunology. 32: 149-58. PMID 1672870 DOI: 10.1016/0165-5728(91)90007-T |
0.652 |
|
| 1991 |
Hafler DA, Chofflon M, Kurt-Jones E, Weiner HL. Interleukin-1 corrects the defective autologous mixed lymphocyte response in multiple sclerosis. Clinical Immunology and Immunopathology. 58: 115-25. PMID 1670583 DOI: 10.1016/0090-1229(91)90153-2 |
0.675 |
|
| 1991 |
Höllsberg P, Wucherpfennig KW, Bierer BE, Hafler DA. HTLV-1 induced spontaneous T cell clonal proliferation is rapamycin sensitive Journal of Neuroimmunology. 35: 201. DOI: 10.1016/0165-5728(91)91225-2 |
0.605 |
|
| 1991 |
Matsui M, Miller A, Hafler DA, Weiner HL. Oral toleralization to keyhole limpet hemocyanin in humans Journal of Neuroimmunology. 35: 85. DOI: 10.1016/0165-5728(91)90995-J |
0.503 |
|
| 1991 |
Wucherpfennig KW, Newcombe J, Cuzner L, Li H, Keddy C, Hafler DA. Analysis of αβ and γδ T cell receptors in multiple sclerosis plaques Journal of Neuroimmunology. 35: 28. DOI: 10.1016/0165-5728(91)90882-8 |
0.632 |
|
| 1990 |
Dang NH, Hafler DA, Schlossman SF, Breitmeyer JB. FcR-mediated crosslinking of Ta1 (CDw26) induces human T lymphocyte activation Cellular Immunology. 125: 42-57. PMID 2152856 DOI: 10.1016/0008-8749(90)90061-U |
0.474 |
|
| 1990 |
Brod SA, Purvee M, Benjamin D, Hafler DA. Frequency analysis of CD4+CD8+ T cells cloned with IL-4 Cellular Immunology. 125: 426-436. PMID 2105169 DOI: 10.1016/0008-8749(90)90096-A |
0.375 |
|
| 1990 |
Brod SA, Purvee M, Benjamin D, Hafler DA. T-T cell interactions are mediated by adhesion molecules. European Journal of Immunology. 20: 2259-2268. PMID 1700751 DOI: 10.1002/Eji.1830201015 |
0.48 |
|
| 1990 |
Ota K, Matsui M, Milford EL, Mackin GA, Weiner HL, Hafler DA. T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature. 346: 183-187. PMID 1694970 DOI: 10.1038/346183A0 |
0.672 |
|
| 1990 |
Wucherpfennig KW, Ota K, Endo N, Seidman JG, Rosenzweig A, Weiner HL, Hafler DA. Shared human T cell receptor V beta usage to immunodominant regions of myelin basic protein. Science (New York, N.Y.). 248: 1016-9. PMID 1693015 DOI: 10.1126/Science.1693015 |
0.726 |
|
| 1989 |
Brod SA, Rudd CE, Purvee M, Hafler DA. Lymphokine regulation of CD45R expression on human T cell clones. Journal of Experimental Medicine. 170: 2147-2152. PMID 2531196 DOI: 10.1084/Jem.170.6.2147 |
0.406 |
|
| 1989 |
Chofflon M, Weiner HL, Morimoto C, Hafler DA. Decrease of suppressor inducer (CD4+2H4+) T cells in multiple sclerosis cerebrospinal fluid. Annals of Neurology. 25: 494-499. PMID 2528316 DOI: 10.1002/Ana.410250512 |
0.652 |
|
| 1989 |
Hafler DA, Brod SA, Weiner HL. Immunoregulation in multiple sclerosis Research in Immunology. 140: 233-239. PMID 2525796 DOI: 10.1016/0923-2494(89)90093-X |
0.585 |
|
| 1989 |
Chofflon M, González V, Weiner HL, Hafler DA. Inflammatory cerebrospinal fluid T cells have activation requirements characteristic of CD4+CD45RA- T cells. European Journal of Immunology. 19: 1791-1795. PMID 2479560 DOI: 10.1002/Eji.1830191005 |
0.642 |
|
| 1989 |
Hafler DA, Weiner HL. MS: a CNS and systematic autoimmune disease Immunology Today. 10: 104-107. PMID 2472810 DOI: 10.1016/0167-5699(89)90236-3 |
0.663 |
|
| 1989 |
Duby AD, Weiner HL, Benjamin DS, Seidman JG, Hafler DA. Sequestration of virus-specific T cells in the cerebrospinal fluid of a patient with varicella zoster viral meningoencephalitis. Journal of Neuroimmunology. 22: 63-8. PMID 2465314 DOI: 10.1016/0165-5728(89)90010-6 |
0.649 |
|
| 1988 |
Weiner HL, Hafler DA. Immunotherapy of multiple sclerosis. Annals of Neurology. 23: 211-222. PMID 3288084 DOI: 10.1002/Ana.410230302 |
0.624 |
|
| 1988 |
Hafler DA, Duby AD, Lee SJ, Benjamin D, Seidman JG, Weiner HL. Oligoclonal T lymphocytes in the cerebrospinal fluid of patients with multiple sclerosis. The Journal of Experimental Medicine. 167: 1313-22. PMID 3258624 DOI: 10.1084/Jem.167.4.1313 |
0.666 |
|
| 1988 |
Chofflon M, Weiner HL, Morimoto C, Hafler DA. Loss of functional suppression is linked to decreases in circulating suppressor inducer (CD4+ 2H4+) T cells in multiple sclerosis. Annals of Neurology. 24: 185-191. PMID 2972249 DOI: 10.1002/Ana.410240203 |
0.663 |
|
| 1988 |
Borst J, van Dongen JJ, Bolhuis RL, Peters PJ, Hafler DA, de Vries E, van de Griend RJ. Distinct molecular forms of human T cell receptor gamma/delta detected on viable T cells by a monoclonal antibody. The Journal of Experimental Medicine. 167: 1625-44. PMID 2966845 DOI: 10.1084/Jem.167.5.1625 |
0.46 |
|
| 1988 |
Hafler DA, Weiner HL. Anti-CD4 and anti-CD2 monoclonal antibody infusions in subjects with multiple sclerosis. Immunosuppressive effects and human antimouse responses. Annals of the New York Academy of Sciences. 540: 557-559. PMID 2905125 DOI: 10.1111/J.1749-6632.1988.Tb27171.X |
0.562 |
|
| 1988 |
Chofflon M, Weiner HL, Hafler DA. Loss of functional suppression is linked to decreases in circulating suppressor-inducer (CD4+ 2H4+) T cells in multiple sclerosis. Annals of the New York Academy of Sciences. 540: 330-332. PMID 2905122 DOI: 10.1111/J.1749-6632.1988.Tb27089.X |
0.63 |
|
| 1988 |
Sobel RA, Hafler DA, Castro EE, Morimoto C, Weiner HL. Immunohistochemical analysis of suppressor-inducer and helper-inducer T cells in multiple sclerosis brain tissue. Annals of the New York Academy of Sciences. 540: 306-8. PMID 2905121 DOI: 10.1016/0165-5728(87)90382-1 |
0.616 |
|
| 1988 |
Carter JL, Dawson DM, Hafler DA, Fallis RJ, Stazzone L, Orav J, Weiner HL. Cumulative experience with high-dose intravenous cyclophosphamide and ACTH therapy in chronic progressive multiple sclerosis. Annals of the New York Academy of Sciences. 540: 535-6. PMID 2849902 DOI: 10.1111/J.1749-6632.1988.Tb27163.X |
0.531 |
|
| 1987 |
Hafler DA, Weiner HL. In vivo labeling of blood T cells: Rapid traffic into cerebrospinal fluid in multiple sclerosis Annals of Neurology. 22: 89-93. PMID 3498435 DOI: 10.1002/Ana.410220121 |
0.672 |
|
| 1987 |
Hafler DA, Weiner HL. T cells in multiple sclerosis and inflammatory central nervous system diseases. Immunological Reviews. 100: 307-332. PMID 3326824 DOI: 10.1111/J.1600-065X.1987.Tb00537.X |
0.667 |
|
| 1987 |
Ang SL, Seidman JG, Peterman GM, Duby AD, Benjamin D, Lee SJ, Hafler DA. Functional gamma chain-associated T cell receptors on cerebrospinal fluid-derived natural killer-like T cell clones. The Journal of Experimental Medicine. 165: 1453-8. PMID 3106557 DOI: 10.1084/Jem.165.5.1453 |
0.437 |
|
| 1987 |
Hafler DA, Fox DA, Benjamin D, Blue ML, Weiner HL. Secondary immune amplification following live poliovirus immunization in humans. Clinical Immunology and Immunopathology. 44: 321-8. PMID 3040309 DOI: 10.1016/0090-1229(87)90076-6 |
0.588 |
|
| 1987 |
Morimoto C, Hafler DA, Weiner HL, Letvin NL, Hagan M, Daley J, Schlossman SF. Selective loss of the suppressor-inducer T-cell subset in progressive multiple sclerosis. Analysis with anti-2H4 monoclonal antibody. The New England Journal of Medicine. 316: 67-72. PMID 2946956 DOI: 10.1056/Nejm198701083160202 |
0.665 |
|
| 1987 |
Weiner HL, Simon L, Hafler DA. Anti-CD4 and anti-CD2 monoclonal antibodies infusions in multiple sclerosis: Immunosuppressive effects and human anti-mouse responses Journal of Neuroimmunology. 16: 180. DOI: 10.1016/0165-5728(87)90410-3 |
0.556 |
|
| 1987 |
Sobel R, Castro E, Hafler D, Morimoto C, Schlossman S, Weiner H. Immunohistochemical analysis of suppressor-inducer and helper-inducer T cells in multiple sclerosis brain tissue Journal of Neuroimmunology. 16: 163-164. DOI: 10.1016/0165-5728(87)90382-1 |
0.571 |
|
| 1987 |
Lee SJ, Benjamin D, Duby A, Ang S, Seidman J, Hafler DA. T-cell receptor-γ-chain clones with natural killer-like activity in the cerebrospinal fluid Journal of Neuroimmunology. 16: 103. DOI: 10.1016/0165-5728(87)90287-6 |
0.376 |
|
| 1987 |
Hafler DA, Duby A, Lee SJ, Seidman DBJ, Weiner HL. Oligocllonal T lymphocytes in the cerebrospinal fluid (CSF) of patients with chronic progressive multiple sclerosis Journal of Neuroimmunology. 16: 69. DOI: 10.1016/0165-5728(87)90234-7 |
0.617 |
|
| 1987 |
Chofflon M, Weiner HL, Hafler DA. Loss of functional suppression is linked to decreases in circulating suppressor-inducer (CD4+2H4+) T cells in multiple sclerosis Journal of Neuroimmunology. 16: 33. DOI: 10.1016/0165-5728(87)90177-9 |
0.63 |
|
| 1987 |
Carter JL, Az S, Dawson DM, Fallis RJ, Hafler DA, Stazzone L, Weiner HL. Immunosuppression with high-dose I.V. cyclophosphamide and acth in progressive multiple sclerosis Journal of Neuroimmunology. 16: 29. DOI: 10.1016/0165-5728(87)90173-1 |
0.536 |
|
| 1986 |
Hafler DA, Fallis RJ, Dawson DM, Schlossman SF, Reinherz EL, Weiner HL. Immunologic responses of progressive multiple sclerosis patients treated with an anti-T-cell monoclonal antibody, anti-T12. Neurology. 36: 777-777. PMID 3486383 DOI: 10.1212/Wnl.36.6.777 |
0.643 |
|
| 1986 |
Johnson D, Hafler DA, Fallis RJ, Lees MB, Brady RO, Quarles RH, Weiner HL. Cell-mediated immunity to myelin-associated glycoprotein, proteolipid protein, and myelin basic protein in multiple sclerosis. Journal of Neuroimmunology. 13: 99-108. PMID 2428837 DOI: 10.1016/0165-5728(86)90053-6 |
0.63 |
|
| 1986 |
Hafler DA, Johnson D, Kelly JJ, Panitch H, Kyle R, Weiner HL. Monoclonal gammopathy and neuropathy: myelin-associated glycoprotein reactivity and clinical characteristics. Neurology. 36: 75-75. PMID 2417161 DOI: 10.1212/Wnl.36.1.75 |
0.542 |
|
| 1985 |
Hafler DA, Hemler ME, Christenson L, Williams JM, Shapiro HM, Strom TB, Strominger JL, Weiner HL. Investigation of in vivo activated T cells in multiple sclerosis and inflammatory central nervous system diseases. Clinical Immunology and Immunopathology. 37: 163-71. PMID 3930113 DOI: 10.1016/0090-1229(85)90147-3 |
0.718 |
|
| 1985 |
Hafler DA, Fox DA, Manning ME, Schlossman SF, Reinherz EL, Weiner HL. In vivo activated T lymphocytes in the peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. The New England Journal of Medicine. 312: 1405-11. PMID 2985995 DOI: 10.1056/Nejm198505303122201 |
0.655 |
|
| 1985 |
Hafler DA, Buchsbaum M, Weiner HL. Decreased autologous mixed lymphocyte reaction in multiple sclerosis Journal of Neuroimmunology. 9: 339-347. PMID 2931449 DOI: 10.1016/S0165-5728(85)80034-5 |
0.655 |
|
| 1985 |
Hafler DA, Buchsbaum M, Johnson D, Weiner HL. Phenotypic and functional analysis of T cells cloned directly from the blood and cerebrospinal fluid of patients with multiple sclerosis Annals of Neurology. 18: 451-458. PMID 2416267 DOI: 10.1002/Ana.410180407 |
0.674 |
|
| 1984 |
Weiner HL, Hafler DA, Fallis RJ, Johnson D, Ault KA, Hauser SL. Altered blood T-cell subsets in patients with multiple sclerosis Journal of Neuroimmunology. 6: 115-121. PMID 6373819 DOI: 10.1016/0165-5728(84)90032-8 |
0.655 |
|
| 1984 |
Tardieu M, Powers ML, Hafler DA, Hauser SL, Weiner HL. Autoimmunity following viral infection: demonstration of monoclonal antibodies against normal tissue following infection of mice with reovirus and demonstration of shared antigenicity between virus and lymphocytes. European Journal of Immunology. 14: 561-565. PMID 6329771 DOI: 10.1002/Eji.1830140614 |
0.536 |
|
| 1984 |
Weiner HL, Hafler DA, Fallis RJ, Johnson D, Ault KA, Hauser SL. T cell subsets in patients with multiple sclerosis. An overview. Annals of the New York Academy of Sciences. 436: 281-290. PMID 6152384 DOI: 10.1111/J.1749-6632.1984.Tb14800.X |
0.667 |
|
| 1984 |
Weiner HL, Hauser SL, Hafler DA, Fallis RJ, Lehrich JR, Dawson DM. The use of cyclophosphamide in the treatment of multiple sclerosis. Annals of the New York Academy of Sciences. 436: 373-381. PMID 6099707 DOI: 10.1111/J.1749-6632.1984.Tb14808.X |
0.548 |
|
| Show low-probability matches. |
