| Year |
Citation |
Score |
| 2023 |
Scott IL, Dominguez MJ, Snow A, Harsini FM, Williams J, Fuson KL, Thapa R, Bhattacharjee P, Cornwall GA, Keyel PA, Sutton RB. Pathogenic Mutations in the C2A Domain of Dysferlin form Amyloid that Activates the Inflammasome. Biorxiv : the Preprint Server For Biology. PMID 37163031 DOI: 10.1101/2023.04.24.538129 |
0.797 |
|
| 2022 |
Dominguez MJ, McCord JJ, Sutton RB. Redefining the architecture of ferlin proteins: Insights into multi-domain protein structure and function. Plos One. 17: e0270188. PMID 35901179 DOI: 10.1371/journal.pone.0270188 |
0.318 |
|
| 2021 |
Padmanarayana M, Liu H, Michelassi F, Li L, Betensky D, Dominguez MJ, Sutton RB, Hu Z, Dittman JS. A unique C2 domain at the C terminus of Munc13 promotes synaptic vesicle priming. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33836576 DOI: 10.1073/pnas.2016276118 |
0.313 |
|
| 2020 |
Bradberry MM, Courtney NA, Dominguez MJ, Lofquist SM, Knox AT, Sutton RB, Chapman ER. Molecular Basis for Synaptotagmin-1-Associated Neurodevelopmental Disorder. Neuron. PMID 32362337 DOI: 10.1016/J.Neuron.2020.04.003 |
0.392 |
|
| 2020 |
Sutton R. Parenchymal pressure injury Ca entry mechanism in pancreatitis. Cell Calcium. 88: 102208. PMID 32361508 DOI: 10.1016/j.ceca.2020.102208 |
0.301 |
|
| 2019 |
Harsini FM, Bui AA, Rice AM, Chebrolu S, Fuson KL, Turtoi A, Bradberry M, Chapman ER, Sutton RB. Structural Basis for the Distinct Membrane Binding Activity of the Homologous C2A Domains of Myoferlin and Dysferlin. Journal of Molecular Biology. PMID 31004665 DOI: 10.1016/J.Jmb.2019.04.006 |
0.811 |
|
| 2019 |
Tertrais M, Bouleau Y, Emptoz A, Belleudy S, Sutton RB, Petit C, Safieddine S, Dulon D. Viral transfer of mini-otoferlins partially restores the fast component of exocytosis and uncovers ultrafast endocytosis in auditory hair cells of otoferlin knock-out mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30833506 DOI: 10.1523/Jneurosci.1550-18.2018 |
0.413 |
|
| 2019 |
Bui AA, Harsini FM, Rice AM, Karmakar S, Fuson K, Sutton RB. Domain Stability and Functional Analysis at the AD3 Locus of Synaptotagmin 1 C2 Domains Biophysical Journal. 116: 526a. DOI: 10.1016/J.Bpj.2018.11.2835 |
0.745 |
|
| 2018 |
Harsini FM, Chebrolu S, Fuson KL, White MA, Rice AM, Sutton RB. FerA is a Membrane-Associating Four-Helix Bundle Domain in the Ferlin Family of Membrane-Fusion Proteins. Scientific Reports. 8: 10949. PMID 30026467 DOI: 10.1038/S41598-018-29184-1 |
0.808 |
|
| 2017 |
Michalski N, Goutman JD, Auclair SM, Boutet de Monvel J, Tertrais M, Emptoz A, Parrin A, Nouaille S, Guillon M, Sachse M, Ciric D, Bahloul A, Hardelin JP, Sutton RB, Avan P, et al. Otoferlin acts as a Ca sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses. Elife. 6. PMID 29111973 DOI: 10.7554/Elife.31013 |
0.392 |
|
| 2017 |
Woolger N, Bournazos A, Sophocleous RA, Evesson FJ, Lek A, Driemer B, Sutton RB, Cooper ST. Limited proteolysis as a tool to probe the tertiary conformation of dysferlin and structural consequences of patient missense variant L344P. The Journal of Biological Chemistry. PMID 28904177 DOI: 10.1074/Jbc.M117.790014 |
0.479 |
|
| 2017 |
Guan Z, Bykhovskaia M, Jorquera RA, Sutton RB, Akbergenova Y, Littleton JT. A synaptotagmin suppressor screen indicates SNARE binding controls the timing and Ca(2+) cooperativity of vesicle fusion. Elife. 6. PMID 28895532 DOI: 10.7554/Elife.28409 |
0.47 |
|
| 2017 |
Piper AK, Ross SE, Redpath GM, Lemckert FA, Woolger N, Bournazos A, Greer PA, Sutton RB, Cooper ST. Enzymatic cleavage of myoferlin releases a dual C2-domain module linked to ERK signalling. Cellular Signalling. PMID 28192161 DOI: 10.1016/J.Cellsig.2017.02.009 |
0.37 |
|
| 2017 |
Harsini F, Rice A, Chebrolu S, Fuson K, Turtoi A, Sutton RB. Homologous C2A Domains of Myoferlin and Dysferlin have Distinct Lipid Binding Specificities Biophysical Journal. 112: 395a. DOI: 10.1016/J.Bpj.2016.11.2146 |
0.82 |
|
| 2016 |
Evans CS, He Z, Bai H, Lou X, Jeggle P, Sutton RB, Edwardson JM, Chapman ER. Functional analysis of the interface between the tandem C2-domains of synaptotagmin-1. Molecular Biology of the Cell. PMID 26792839 DOI: 10.1091/Mbc.E15-07-0503 |
0.657 |
|
| 2016 |
Harsini F, Rice A, Fuson K, Sutton RB. Inversion of Ligand Binding Preferences in Re-Engineered Dysferlin C2Av1 Biophysical Journal. 110: 431a-432a. DOI: 10.1016/J.Bpj.2015.11.2330 |
0.824 |
|
| 2015 |
Voronina S, Collier D, Chvanov M, Middlehurst B, Beckett AJ, Prior IA, Criddle DN, Begg M, Mikoshiba K, Sutton R, Tepikin AV. The role of Ca2+ influx in endocytic vacuole formation in pancreatic acinar cells. The Biochemical Journal. 465: 405-12. PMID 25370603 DOI: 10.1042/BJ20140398 |
0.348 |
|
| 2014 |
Rice AM, Mahling R, Fealey ME, Rannikko A, Dunleavy K, Hendrickson T, Lohese KJ, Kruggel S, Heiling H, Harren D, Sutton RB, Pastor J, Hinderliter A. Randomly organized lipids and marginally stable proteins: a coupling of weak interactions to optimize membrane signaling. Biochimica Et Biophysica Acta. 1838: 2331-40. PMID 24657395 DOI: 10.1016/J.Bbamem.2014.03.005 |
0.409 |
|
| 2014 |
Fuson K, Rice A, Mahling R, Snow A, Nayak K, Shanbhogue P, Meyer AG, Redpath GM, Hinderliter A, Cooper ST, Sutton RB. Alternate splicing of dysferlin C2A confers Ca²âº-dependent and Ca²âº-independent binding for membrane repair. Structure (London, England : 1993). 22: 104-15. PMID 24239457 DOI: 10.1016/J.Str.2013.10.001 |
0.81 |
|
| 2014 |
Hendrickson TA, Gauer JW, Mahling R, Lohese KJ, Fealey ME, Sutton RB, Hinderliter A. Synaptotagmin Linker: Tuning of Cooperativity in Calcium Ion Binding Biophysical Journal. 106: 678a. DOI: 10.1016/J.Bpj.2013.11.3756 |
0.524 |
|
| 2014 |
Mahling RW, Fealey ME, Gauer JW, Lohese KJ, Hendrickson T, Sutton RB, Hinderliter A. Thermodynamic Impact of the Unstructured Linker Region on the Synaptotagmin I C2A Domain Biophysical Journal. 106: 528a-529a. DOI: 10.1016/J.Bpj.2013.11.2948 |
0.53 |
|
| 2013 |
Xu M, Ma L, Bujalowski PJ, Qian F, Sutton RB, Oberhauser AF. Analysis of the REJ Module of Polycystin-1 Using Molecular Modeling and Force-Spectroscopy Techniques. Journal of Biophysics (Hindawi Publishing Corporation : Online). 2013: 525231. PMID 23762046 DOI: 10.1155/2013/525231 |
0.334 |
|
| 2013 |
Mahling RW, Fealy ME, Gauer JW, Sutton RB, Hinderliter A. Thermodynamic Comparison of Dysferlin C2A Wild Type, and C2A V-1 Domains, to the Synaptotamin I C2A and C2B Domains Biophysical Journal. 104: 102a. DOI: 10.1016/J.Bpj.2012.11.599 |
0.554 |
|
| 2013 |
Rice AM, Hinderliter A, Sutton RB. Elucidation of Calcium Ion and Phospholipid Binding Profiles of Multiple Dysferlin Isoforms Biophysical Journal. 104: 593a. DOI: 10.1016/J.Bpj.2012.11.3294 |
0.492 |
|
| 2012 |
Fealey ME, Gauer JW, Kempka SC, Miller K, Nayak K, Sutton RB, Hinderliter A. Negative coupling as a mechanism for signal propagation between C2 domains of synaptotagmin I. Plos One. 7: e46748. PMID 23071627 DOI: 10.1371/Journal.Pone.0046748 |
0.555 |
|
| 2012 |
McCann JJ, Zheng L, Rohrbeck D, Felekyan S, Kühnemuth R, Sutton RB, Seidel CA, Bowen ME. Supertertiary structure of the synaptic MAGuK scaffold proteins is conserved. Proceedings of the National Academy of Sciences of the United States of America. 109: 15775-80. PMID 23019361 DOI: 10.1073/Pnas.1200254109 |
0.445 |
|
| 2012 |
Gauer JW, Sisk R, Murphy JR, Jacobson H, Sutton RB, Gillispie GD, Hinderliter A. Mechanism for calcium ion sensing by the C2A domain of synaptotagmin I. Biophysical Journal. 103: 238-46. PMID 22853901 DOI: 10.1016/J.Bpj.2012.05.051 |
0.643 |
|
| 2012 |
Striegel AR, Biela LM, Evans CS, Wang Z, Delehoy JB, Sutton RB, Chapman ER, Reist NE. Calcium binding by synaptotagmin's C2A domain is an essential element of the electrostatic switch that triggers synchronous synaptic transmission. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 1253-60. PMID 22279210 DOI: 10.1523/Jneurosci.4652-11.2012 |
0.642 |
|
| 2012 |
Lek A, Evesson FJ, Sutton RB, North KN, Cooper ST. Ferlins: regulators of vesicle fusion for auditory neurotransmission, receptor trafficking and membrane repair. Traffic (Copenhagen, Denmark). 13: 185-94. PMID 21838746 DOI: 10.1111/J.1600-0854.2011.01267.X |
0.488 |
|
| 2012 |
McCann JJ, Sutton RB, Bowen ME. Structural Modeling of PSD-95 and other MAGUKs using Single-Molecule FRET Biophysical Journal. 102: 445a. DOI: 10.1016/J.Bpj.2011.11.2438 |
0.413 |
|
| 2011 |
Lur G, Sherwood MW, Ebisui E, Haynes L, Feske S, Sutton R, Burgoyne RD, Mikoshiba K, Petersen OH, Tepikin AV. InsP₃receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences. The Biochemical Journal. 436: 231-9. PMID 21568942 DOI: 10.1042/Bj20110083 |
0.321 |
|
| 2011 |
Kempka SC, Miller K, Gauer JW, Sutton RB, Gillispie G, Hinderliter A. Utilization of Thermodynamic Linkage Relationships to Test for Interactions between the C2 Domains of Synaptotagmin 1 Biophysical Journal. 100: 545a. DOI: 10.1016/J.Bpj.2010.12.3176 |
0.419 |
|
| 2011 |
Gauer JW, Jaworski SR, Sutton RB, Gillispie G, Hinderliter A. Ligand Induced Conformational Redistribution in Synaptotagmin I C2A Biophysical Journal. 100: 510a-511a. DOI: 10.1016/J.Bpj.2010.12.2987 |
0.472 |
|
| 2011 |
Fuson KL, Quisenberry N, Walz T, Dukovski D, Hinderliter A, Sutton RB. Structure and Mutation Analysis of the C2A Domain of Human Dysferlin Provides a Thermodynamic Basis for Limb-Girdle Muscular Dystrophy Biophysical Journal. 100: 410a. DOI: 10.1016/J.Bpj.2010.12.2432 |
0.486 |
|
| 2010 |
Vrljic M, Strop P, Ernst JA, Sutton RB, Chu S, Brunger AT. Molecular mechanism of the synaptotagmin-SNARE interaction in Ca2+-triggered vesicle fusion. Nature Structural & Molecular Biology. 17: 325-31. PMID 20173762 DOI: 10.1038/Nsmb.1764 |
0.75 |
|
| 2010 |
Fuson K, Knutson K, Meyer A, Gauer JW, Murphy J, Hinderliter A, Sutton RB. Link between Structure and Cooperativity in the C2a Domains of Synaptotagmin Biophysical Journal. 98: 678a. DOI: 10.1016/J.Bpj.2009.12.3727 |
0.807 |
|
| 2010 |
Gauer JW, Murphy J, Knutson K, Sutton RB, Gillispie G, Hinderliter A. Conformational Flexibility in Membrane Binding Proteins: Synaptotagmin I C2A Biophysical Journal. 98: 271a. DOI: 10.1016/J.Bpj.2009.12.1479 |
0.476 |
|
| 2010 |
Murphy JR, Knutson KJ, Gauer JW, Sutton RB, Hinderliter A. Diminished Cooperativity: Comparing Linker Lengths in Synaptotagmin I C2A Domain Biophysical Journal. 98: 244a. DOI: 10.1016/J.Bpj.2009.12.1326 |
0.546 |
|
| 2009 |
Baumgartner HK, Gerasimenko JV, Thorne C, Ferdek P, Pozzan T, Tepikin AV, Petersen OH, Sutton R, Watson AJ, Gerasimenko OV. Calcium elevation in mitochondria is the main Ca2+ requirement for mitochondrial permeability transition pore (mPTP) opening. The Journal of Biological Chemistry. 284: 20796-803. PMID 19515844 DOI: 10.1074/jbc.M109.025353 |
0.331 |
|
| 2009 |
Fuson KL, Ma L, Sutton RB, Oberhauser AF. The c2 domains of human synaptotagmin 1 have distinct mechanical properties. Biophysical Journal. 96: 1083-90. PMID 19186144 DOI: 10.1016/J.Bpj.2008.10.025 |
0.637 |
|
| 2009 |
Vrljic M, Strop P, Ernst J, Sutton RB, Chu S, Brunger AT. Relative Rearrangements Of Synaptotagmin3 C2A And C2B Domains Are Influenced ay Calcium, Lipids And SNARE Proteins Biophysical Journal. 96: 358a-359a. DOI: 10.1016/J.Bpj.2008.12.1809 |
0.762 |
|
| 2009 |
Gauer JW, Lange C, Montes M, Fuson K, Knutson K, Murphy J, Sutton RB, Gillispie G, Hinderliter A. The Energetics of the Denaturation of the C2A Domain of Synaptotagmin I Biophysical Journal. 96: 332a. DOI: 10.1016/J.Bpj.2008.12.1675 |
0.487 |
|
| 2009 |
Murphy J, Houghton A, Knutson KJ, Gauer J, Fuson K, Montes M, Sutton RB, Hinderliter A. Synaptotagmin's Role as the Ca2+ Sensor in Regulated Exocytosis Biophysical Journal. 96: 269a. DOI: 10.1016/J.Bpj.2008.12.1330 |
0.52 |
|
| 2008 |
Greene DN, Garcia T, Sutton RB, Gernert KM, Benian GM, Oberhauser AF. Single-molecule force spectroscopy reveals a stepwise unfolding of Caenorhabditis elegans giant protein kinase domains. Biophysical Journal. 95: 1360-70. PMID 18390597 DOI: 10.1529/Biophysj.108.130237 |
0.339 |
|
| 2007 |
Fuson KL, Montes M, Robert JJ, Sutton RB. Structure of human synaptotagmin 1 C2AB in the absence of Ca2+ reveals a novel domain association. Biochemistry. 46: 13041-8. PMID 17956130 DOI: 10.1021/bi701651k |
0.634 |
|
| 2007 |
Criddle DN, Gerasimenko JV, Baumgartner HK, Jaffar M, Voronina S, Sutton R, Petersen OH, Gerasimenko OV. Calcium signalling and pancreatic cell death: apoptosis or necrosis? Cell Death and Differentiation. 14: 1285-94. PMID 17431416 DOI: 10.1038/sj.cdd.4402150 |
0.311 |
|
| 2007 |
Lagow RD, Bao H, Cohen EN, Daniels RW, Zuzek A, Williams WH, Macleod GT, Sutton RB, Zhang B. Modification of a hydrophobic layer by a point mutation in syntaxin 1A regulates the rate of synaptic vesicle fusion. Plos Biology. 5: e72. PMID 17341138 DOI: 10.1371/Journal.Pbio.0050072 |
0.412 |
|
| 2007 |
Criddle DN, Sutton R, Petersen OH. Role of Ca2+ in pancreatic cell death induced by alcohol metabolites. Journal of Gastroenterology and Hepatology. S14-7. PMID 16958662 DOI: 10.1111/j.1440-1746.2006.04577.x |
0.306 |
|
| 2006 |
Petersen OH, Sutton R, Criddle DN. Failure of calcium microdomain generation and pathological consequences. Cell Calcium. 40: 593-600. PMID 17049597 DOI: 10.1016/j.ceca.2006.08.020 |
0.356 |
|
| 2006 |
Montes M, Fuson KL, Sutton RB, Robert JJ. Purification, crystallization and X-ray diffraction analysis of human synaptotagmin 1 C2A-C2B Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 62: 926-929. PMID 16946482 DOI: 10.1107/S1744309106029253 |
0.579 |
|
| 2006 |
Petersen OH, Sutton R. Ca2+ signalling and pancreatitis: effects of alcohol, bile and coffee. Trends in Pharmacological Sciences. 27: 113-20. PMID 16406087 DOI: 10.1016/j.tips.2005.12.006 |
0.348 |
|
| 2005 |
Peng BH, White MA, Campbell GA, Robert JJ, Lee JC, Sutton RB. Crystallization and preliminary X-ray diffraction of the ZO-binding domain of human occludin. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 61: 369-71. PMID 16511043 DOI: 10.1107/S1744309105007475 |
0.351 |
|
| 2005 |
Sutton RB, Vishnivetskiy SA, Robert J, Hanson SM, Raman D, Knox BE, Kono M, Navarro J, Gurevich VV. Crystal structure of cone arrestin at 2.3A: evolution of receptor specificity. Journal of Molecular Biology. 354: 1069-80. PMID 16289201 DOI: 10.1016/J.Jmb.2005.10.023 |
0.321 |
|
| 2004 |
Criddle DN, Raraty MG, Neoptolemos JP, Tepikin AV, Petersen OH, Sutton R. Ethanol toxicity in pancreatic acinar cells: mediation by nonoxidative fatty acid metabolites. Proceedings of the National Academy of Sciences of the United States of America. 101: 10738-43. PMID 15247419 DOI: 10.1073/pnas.0403431101 |
0.306 |
|
| 2003 |
Furst J, Sutton RB, Chen J, Brunger AT, Grigorieff N. Electron cryomicroscopy structure of N-ethyl maleimide sensitive factor at 11 A resolution. The Embo Journal. 22: 4365-74. PMID 12941689 DOI: 10.1093/Emboj/Cdg420 |
0.588 |
|
| 2000 |
Raraty M, Ward J, Erdemli G, Vaillant C, Neoptolemos JP, Sutton R, Petersen OH. Calcium-dependent enzyme activation and vacuole formation in the apical granular region of pancreatic acinar cells Proceedings of the National Academy of Sciences of the United States of America. 97: 13126-13131. PMID 11087863 DOI: 10.1073/Pnas.97.24.13126 |
0.345 |
|
| 2000 |
Raraty MG, Petersen OH, Sutton R, Neoptolemos JP. Intracellular free ionized calcium in the pathogenesis of acute pancreatitis. Bailliere's Best Practice & Research. Clinical Gastroenterology. 13: 241-51. PMID 11030604 DOI: 10.1053/bega.1999.0022 |
0.305 |
|
| 1999 |
Sutton RB, Ernst JA, Brunger AT. Crystal structure of the cytosolic C2A-C2B domains of synaptotagmin III. Implications for Ca(+2)-independent snare complex interaction. The Journal of Cell Biology. 147: 589-98. PMID 10545502 DOI: 10.1083/Jcb.147.3.589 |
0.785 |
|
| 1998 |
Fasshauer D, Sutton RB, Brunger AT, Jahn R. Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREs. Proceedings of the National Academy of Sciences of the United States of America. 95: 15781-6. PMID 9861047 DOI: 10.1073/pnas.95.26.15781 |
0.504 |
|
| 1998 |
Sutton RB, Sprang SR. Structure of the protein kinase Cbeta phospholipid-binding C2 domain complexed with Ca2+. Structure (London, England : 1993). 6: 1395-405. PMID 9817842 DOI: 10.1016/S0969-2126(98)00139-7 |
0.757 |
|
| 1998 |
Sutton RB, Fasshauer D, Jahn R, Brunger AT. Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution. Nature. 395: 347-53. PMID 9759724 DOI: 10.1038/26412 |
0.521 |
|
| 1996 |
Shao X, Davletov BA, Sutton RB, Südhof TC, Rizo J. Bipartite Ca2+-binding motif in C2 domains of synaptotagmin and protein kinase C. Science (New York, N.Y.). 273: 248-51. PMID 8662510 DOI: 10.1126/Science.273.5272.248 |
0.484 |
|
| 1995 |
Sutton RB, Davletov BA, Berghuis AM, Südhof TC, Sprang SR. Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold. Cell. 80: 929-38. PMID 7697723 DOI: 10.1016/0092-8674(95)90296-1 |
0.765 |
|
| 1995 |
Ward JB, Petersen OH, Jenkins SA, Sutton R. Is an elevated concentration of acinar cytosolic free ionised calcium the trigger for acute pancreatitis? Lancet (London, England). 346: 1016-9. PMID 7475553 DOI: 10.1016/S0140-6736(95)91695-4 |
0.308 |
|
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