Patrick Rorsman, Ph.D. - Publications

Affiliations: 
 

204 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Tarasov AI, Rorsman P. Dramatis Personae in β-Cell Mass Regulation: Enter SerpinB1. Cell Metabolism. 23: 8-10. PMID 26771113 DOI: 10.1016/j.cmet.2015.12.011  0.96
2016 Vinnakota KC, Cha CY, Rorsman P, Balaban RS, Gerche AL, Wade-Martins R, Beard DA, Jeneson JAL. Improving the physiological realism of experimental models Interface Focus. 6. DOI: 10.1098/rsfs.2015.0076  0.96
2015 Cane MC, Parrington J, Rorsman P, Galione A, Rutter GA. The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca(2+) dynamics and insulin secretion. Cell Calcium. PMID 26769314 DOI: 10.1016/j.ceca.2015.12.004  0.96
2015 Shigeto M, Ramracheya R, Tarasov AI, Cha CY, Chibalina MV, Hastoy B, Philippaert K, Reinbothe T, Rorsman N, Salehi A, Sones WR, Vergari E, Weston C, Gorelik J, Katsura M, ... ... Rorsman P, et al. GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation. The Journal of Clinical Investigation. PMID 26571400 DOI: 10.1172/JCI81975  0.96
2015 Arredouani A, Ruas M, Collins SC, Parkesh R, Clough F, Pillinger T, Coltart G, Rietdorf K, Royle A, Johnson P, Braun M, Zhang Q, Sones W, Shimomura K, Morgan AJ, ... ... Rorsman P, et al. NAADP and endolysosomal two-pore channels modulate membrane excitability and stimulus-secretion coupling in mouse pancreatic β cells. The Journal of Biological Chemistry. PMID 26152717 DOI: 10.1074/jbc.M115.671248  0.96
2015 Szabat M, Modi H, Ramracheya R, Girbinger V, Chan F, Lee JTC, Piske M, Kamal S, Yang YHC, Welling A, Rorsman P, Johnson JD. High-content screening identifies a role for Na+ channels in insulin production Royal Society Open Science. 2. DOI: 10.1098/rsos.150306  0.96
2015 Wu B, Wei S, Petersen N, Ali Y, Wang X, Bacaj T, Rorsman P, Hong W, Südhof TC, Han W. Synaptotagmin-7 phosphorylation mediates GLP-1-dependent potentiation of insulin secretion from β-cells Proceedings of the National Academy of Sciences of the United States of America. 112: 9996-10001. DOI: 10.1073/pnas.1513004112  0.96
2014 Chandra V, Albagli-Curiel O, Hastoy B, Piccand J, Randriamampita C, Vaillant E, Cavé H, Busiah K, Froguel P, Vaxillaire M, Rorsman P, Polak M, Scharfmann R. RFX6 regulates insulin secretion by modulating Ca2+ homeostasis in human β cells. Cell Reports. 9: 2206-18. PMID 25497100 DOI: 10.1016/j.celrep.2014.11.010  0.96
2014 Gheni G, Ogura M, Iwasaki M, Yokoi N, Minami K, Nakayama Y, Harada K, Hastoy B, Wu X, Takahashi H, Kimura K, Matsubara T, Hoshikawa R, Hatano N, Sugawara K, ... ... Rorsman P, et al. Glutamate acts as a key signal linking glucose metabolism to incretin/cAMP action to amplify insulin secretion. Cell Reports. 9: 661-73. PMID 25373904 DOI: 10.1016/j.celrep.2014.09.030  0.96
2014 Rorsman P, Zhang Q. Matthias Braun, 23 July 1966-16 November 2013. Diabetologia. 57: 2431-2. PMID 25312812 DOI: 10.1007/s00125-014-3401-y  0.96
2014 Zhang Q, Chibalina MV, Bengtsson M, Groschner LN, Ramracheya R, Rorsman NJ, Leiss V, Nassar MA, Welling A, Gribble FM, Reimann F, Hofmann F, Wood JN, Ashcroft FM, Rorsman P. Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression. The Journal of Physiology. 592: 4677-96. PMID 25172946 DOI: 10.1113/jphysiol.2014.274209  0.96
2014 Brereton MF, Iberl M, Shimomura K, Zhang Q, Adriaenssens AE, Proks P, Spiliotis II, Dace W, Mattis KK, Ramracheya R, Gribble FM, Reimann F, Clark A, Rorsman P, Ashcroft FM. Reversible changes in pancreatic islet structure and function produced by elevated blood glucose. Nature Communications. 5: 4639. PMID 25145789 DOI: 10.1038/ncomms5639  0.96
2014 Rorsman P, Ramracheya R, Rorsman NJ, Zhang Q. ATP-regulated potassium channels and voltage-gated calcium channels in pancreatic alpha and beta cells: similar functions but reciprocal effects on secretion. Diabetologia. 57: 1749-61. PMID 24906950 DOI: 10.1007/s00125-014-3279-8  0.96
2014 Latreille M, Hausser J, Stützer I, Zhang Q, Hastoy B, Gargani S, Kerr-Conte J, Pattou F, Zavolan M, Esguerra JL, Eliasson L, Rülicke T, Rorsman P, Stoffel M. MicroRNA-7a regulates pancreatic β cell function. The Journal of Clinical Investigation. 124: 2722-35. PMID 24789908 DOI: 10.1172/JCI73066  0.96
2013 Soni A, Amisten S, Rorsman P, Salehi A. GPRC5B a putative glutamate-receptor candidate is negative modulator of insulin secretion. Biochemical and Biophysical Research Communications. PMID 24513213 DOI: 10.1016/j.bbrc.2013.10.099  0.96
2013 Zhang Q, Ramracheya R, Lahmann C, Tarasov A, Bengtsson M, Braha O, Braun M, Brereton M, Collins S, Galvanovskis J, Gonzalez A, Groschner LN, Rorsman NJ, Salehi A, Travers ME, ... ... Rorsman P, et al. Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes. Cell Metabolism. 18: 871-82. PMID 24315372 DOI: 10.1016/j.cmet.2013.10.014  0.96
2013 Ashcroft FM, Rorsman P. K(ATP) channels and islet hormone secretion: new insights and controversies. Nature Reviews. Endocrinology. 9: 660-9. PMID 24042324 DOI: 10.1038/nrendo.2013.166  0.96
2013 Amisten S, Salehi A, Rorsman P, Jones PM, Persaud SJ. An atlas and functional analysis of G-protein coupled receptors in human islets of Langerhans. Pharmacology & Therapeutics. 139: 359-91. PMID 23694765 DOI: 10.1016/j.pharmthera.2013.05.004  0.96
2013 McCarthy MI, Rorsman P, Gloyn AL. TCF7L2 and diabetes: a tale of two tissues, and of two species. Cell Metabolism. 17: 157-9. PMID 23395164 DOI: 10.1016/j.cmet.2013.01.011  0.96
2013 Rorsman P, Braun M. Regulation of insulin secretion in human pancreatic islets. Annual Review of Physiology. 75: 155-79. PMID 22974438 DOI: 10.1146/annurev-physiol-030212-183754  0.96
2012 Kailey B, van de Bunt M, Cheley S, Johnson PR, MacDonald PE, Gloyn AL, Rorsman P, Braun M. SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells. American Journal of Physiology. Endocrinology and Metabolism. 303: E1107-16. PMID 22932785 DOI: 10.1152/ajpendo.00207.2012  0.96
2012 Braun M, Ramracheya R, Rorsman P. Autocrine regulation of insulin secretion. Diabetes, Obesity & Metabolism. 14: 143-51. PMID 22928575 DOI: 10.1111/j.1463-1326.2012.01642.x  0.96
2012 Salehi A, Gunnerud U, Muhammed SJ, Ostman E, Holst JJ, Björck I, Rorsman P. The insulinogenic effect of whey protein is partially mediated by a direct effect of amino acids and GIP on β-cells. Nutrition & Metabolism. 9: 48. PMID 22647249 DOI: 10.1186/1743-7075-9-48  0.96
2012 Rosengren AH, Braun M, Mahdi T, Andersson SA, Travers ME, Shigeto M, Zhang E, Almgren P, Ladenvall C, Axelsson AS, Edlund A, Pedersen MG, Jonsson A, Ramracheya R, Tang Y, ... ... Rorsman P, et al. Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes. Diabetes. 61: 1726-33. PMID 22492527 DOI: 10.2337/db11-1516  0.96
2012 Ashcroft FM, Rorsman P. Diabetes mellitus and the β cell: the last ten years. Cell. 148: 1160-71. PMID 22424227 DOI: 10.1016/j.cell.2012.02.010  0.96
2012 Hoppa MB, Jones E, Karanauskaite J, Ramracheya R, Braun M, Collins SC, Zhang Q, Clark A, Eliasson L, Genoud C, Macdonald PE, Monteith AG, Barg S, Galvanovskis J, Rorsman P. Multivesicular exocytosis in rat pancreatic beta cells. Diabetologia. 55: 1001-12. PMID 22189485 DOI: 10.1007/s00125-011-2400-5  0.96
2012 Rorsman P, Braun M, Zhang Q. Regulation of calcium in pancreatic α- and β-cells in health and disease. Cell Calcium. 51: 300-8. PMID 22177710 DOI: 10.1016/j.ceca.2011.11.006  0.96
2012 Yashiro H, Tsujihata Y, Takeuchi K, Hazama M, Johnson PR, Rorsman P. The effects of TAK-875, a selective G protein-coupled receptor 40/free fatty acid 1 agonist, on insulin and glucagon secretion in isolated rat and human islets. The Journal of Pharmacology and Experimental Therapeutics. 340: 483-9. PMID 22106100 DOI: 10.1124/jpet.111.187708  0.96
2011 Galvanovskis J, Braun M, Rorsman P. Exocytosis from pancreatic β-cells: mathematical modelling of the exit of low-molecular-weight granule content. Interface Focus. 1: 143-52. PMID 22419980 DOI: 10.1098/rsfs.2010.0006  0.96
2011 Walker JN, Ramracheya R, Zhang Q, Johnson PR, Braun M, Rorsman P. Regulation of glucagon secretion by glucose: paracrine, intrinsic or both? Diabetes, Obesity & Metabolism. 13: 95-105. PMID 21824262 DOI: 10.1111/j.1463-1326.2011.01450.x  0.96
2011 Rorsman P, Eliasson L, Kanno T, Zhang Q, Gopel S. Electrophysiology of pancreatic β-cells in intact mouse islets of Langerhans. Progress in Biophysics and Molecular Biology. 107: 224-35. PMID 21762719 DOI: 10.1016/j.pbiomolbio.2011.06.009  0.96
2011 MacDonald PE, Rorsman P. Per-arnt-sim (PAS) domain kinase (PASK) as a regulator of glucagon secretion. Diabetologia. 54: 719-21. PMID 21327866 DOI: 10.1007/s00125-011-2072-1  0.96
2011 Walker JN, Johnson PR, Shigeto M, Hughes SJ, Clark A, Rorsman P. Glucose-responsive beta cells in islets isolated from a patient with long-standing type 1 diabetes mellitus. Diabetologia. 54: 200-2. PMID 20963398 DOI: 10.1007/s00125-010-1930-6  0.96
2011 Hoppa MB, Collins S, Ramracheya R, Hodson L, Amisten S, Zhang Q, Johnson P, Ashcroft FM, Rorsman P. Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca2+ channels from secretory granules (Cell Metabolism) Cell Metabolism. 13: 487. DOI: 10.1016/j.cmet.2011.03.002  0.96
2010 Akhmedov D, Braun M, Mataki C, Park KS, Pozzan T, Schoonjans K, Rorsman P, Wollheim CB, Wiederkehr A. Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 4613-26. PMID 20647546 DOI: 10.1096/fj.10-162222  0.96
2010 Clark RH, McTaggart JS, Webster R, Mannikko R, Iberl M, Sim XL, Rorsman P, Glitsch M, Beeson D, Ashcroft FM. Muscle dysfunction caused by a KATP channel mutation in neonatal diabetes is neuronal in origin. Science (New York, N.Y.). 329: 458-61. PMID 20595581 DOI: 10.1126/science.1186146  0.96
2010 Braun M, Rorsman P. The glucagon-producing alpha cell: an electrophysiologically exceptional cell. Diabetologia. 53: 1827-30. PMID 20556353 DOI: 10.1007/s00125-010-1823-8  0.96
2010 Ramracheya R, Ward C, Shigeto M, Walker JN, Amisten S, Zhang Q, Johnson PR, Rorsman P, Braun M. Membrane potential-dependent inactivation of voltage-gated ion channels in alpha-cells inhibits glucagon secretion from human islets. Diabetes. 59: 2198-208. PMID 20547976 DOI: 10.2337/db09-1505  0.96
2010 De Marinis YZ, Salehi A, Ward CE, Zhang Q, Abdulkader F, Bengtsson M, Braha O, Braun M, Ramracheya R, Amisten S, Habib AM, Moritoh Y, Zhang E, Reimann F, Rosengren AH, ... ... Rorsman P, et al. GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis. Cell Metabolism. 11: 543-53. PMID 20519125 DOI: 10.1016/j.cmet.2010.04.007  0.96
2010 Jeyabalan J, Nesbit MA, Galvanovskis J, Callaghan R, Rorsman P, Thakker RV. SEDLIN forms homodimers: characterisation of SEDLIN mutations and their interactions with transcription factors MBP1, PITX1 and SF1. Plos One. 5: e10646. PMID 20498720 DOI: 10.1371/journal.pone.0010646  0.96
2010 Braun M, Ramracheya R, Bengtsson M, Clark A, Walker JN, Johnson PR, Rorsman P. Gamma-aminobutyric acid (GABA) is an autocrine excitatory transmitter in human pancreatic beta-cells. Diabetes. 59: 1694-701. PMID 20413510 DOI: 10.2337/db09-0797  0.96
2010 Collins SC, Hoppa MB, Walker JN, Amisten S, Abdulkader F, Bengtsson M, Fearnside J, Ramracheya R, Toye AA, Zhang Q, Clark A, Gauguier D, Rorsman P. Progression of diet-induced diabetes in C57BL6J mice involves functional dissociation of Ca2(+) channels from secretory vesicles. Diabetes. 59: 1192-201. PMID 20150285 DOI: 10.2337/db09-0791  0.96
2010 Obermüller S, Calegari F, King A, Lindqvist A, Lundquist I, Salehi A, Francolini M, Rosa P, Rorsman P, Huttner WB, Barg S. Defective secretion of islet hormones in chromogranin-B deficient mice. Plos One. 5: e8936. PMID 20126668 DOI: 10.1371/journal.pone.0008936  0.96
2010 De Marinis YZ, Zhang E, Amisten S, Taneera J, Renström E, Rorsman P, Eliasson L. Enhancement of glucagon secretion in mouse and human pancreatic alpha cells by protein kinase C (PKC) involves intracellular trafficking of PKCalpha and PKCdelta. Diabetologia. 53: 717-29. PMID 20020096 DOI: 10.1007/s00125-009-1635-x  0.96
2010 Rosengren AH, Jokubka R, Tojjar D, Granhall C, Hansson O, Li DQ, Nagaraj V, Reinbothe TM, Tuncel J, Eliasson L, Groop L, Rorsman P, Salehi A, Lyssenko V, Luthman H, et al. Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes. Science (New York, N.Y.). 327: 217-20. PMID 19965390 DOI: 10.1126/science.1176827  0.96
2010 Reed AA, Loh NY, Terryn S, Lippiat JD, Partridge C, Galvanovskis J, Williams SE, Jouret F, Wu FT, Courtoy PJ, Nesbit MA, Rorsman P, Devuyst O, Ashcroft FM, Thakker RV. CLC-5 and KIF3B interact to facilitate CLC-5 plasma membrane expression, endocytosis, and microtubular transport: relevance to pathophysiology of Dent's disease. American Journal of Physiology. Renal Physiology. 298: F365-80. PMID 19940036 DOI: 10.1152/ajprenal.00038.2009  0.96
2009 Santesson S, Degerman E, Rorsman P, Johansson T, Lemos S, Nilsson S. Cell-cell communication between adipocytes and pancreatic beta-cells in acoustically levitated droplets. Integrative Biology : Quantitative Biosciences From Nano to Macro. 1: 595-601. PMID 20023776 DOI: 10.1039/b907834g  0.96
2009 Hoppa MB, Collins S, Ramracheya R, Hodson L, Amisten S, Zhang Q, Johnson P, Ashcroft FM, Rorsman P. Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules. Cell Metabolism. 10: 455-65. PMID 19945403 DOI: 10.1016/j.cmet.2009.09.011  0.96
2009 Li DQ, Jing X, Salehi A, Collins SC, Hoppa MB, Rosengren AH, Zhang E, Lundquist I, Olofsson CS, Mörgelin M, Eliasson L, Rorsman P, Renström E. Suppression of sulfonylurea- and glucose-induced insulin secretion in vitro and in vivo in mice lacking the chloride transport protein ClC-3. Cell Metabolism. 10: 309-15. PMID 19808023 DOI: 10.1016/j.cmet.2009.08.011  0.96
2009 Gilon P, Rorsman P. NALCN: a regulated leak channel. Embo Reports. 10: 963-4. PMID 19662077 DOI: 10.1038/embor.2009.185  0.96
2009 Williams SE, Reed AA, Galvanovskis J, Antignac C, Goodship T, Karet FE, Kotanko P, Lhotta K, Morinière V, Williams P, Wong W, Rorsman P, Thakker RV. Uromodulin mutations causing familial juvenile hyperuricaemic nephropathy lead to protein maturation defects and retention in the endoplasmic reticulum. Human Molecular Genetics. 18: 2963-74. PMID 19465746 DOI: 10.1093/hmg/ddp235  0.96
2009 Braun M, Ramracheya R, Amisten S, Bengtsson M, Moritoh Y, Zhang Q, Johnson PR, Rorsman P. Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells. Diabetologia. 52: 1566-78. PMID 19440689 DOI: 10.1007/s00125-009-1382-z  0.96
2009 Gromada J, Duttaroy A, Rorsman P. The insulin receptor talks to glucagon? Cell Metabolism. 9: 303-5. PMID 19356709 DOI: 10.1016/j.cmet.2009.03.008  0.96
2009 Gloyn AL, Braun M, Rorsman P. Type 2 diabetes susceptibility gene TCF7L2 and its role in beta-cell function. Diabetes. 58: 800-2. PMID 19336690 DOI: 10.2337/db09-0099  0.96
2009 Poy MN, Hausser J, Trajkovski M, Braun M, Collins S, Rorsman P, Zavolan M, Stoffel M. miR-375 maintains normal pancreatic alpha- and beta-cell mass. Proceedings of the National Academy of Sciences of the United States of America. 106: 5813-8. PMID 19289822 DOI: 10.1073/pnas.0810550106  0.96
2009 Olofsson CS, HÃ¥kansson J, Salehi A, Bengtsson M, Galvanovskis J, Partridge C, SörhedeWinzell M, Xian X, Eliasson L, Lundquist I, Semb H, Rorsman P. Impaired insulin exocytosis in neural cell adhesion molecule-/- mice due to defective reorganization of the submembrane F-actin network. Endocrinology. 150: 3067-75. PMID 19213846 DOI: 10.1210/en.2008-0475  0.96
2009 Gustavsson N, Wei SH, Hoang DN, Lao Y, Zhang Q, Radda GK, Rorsman P, Südhof TC, Han W. Synaptotagmin-7 is a principal Ca2+ sensor for Ca2+ -induced glucagon exocytosis in pancreas. The Journal of Physiology. 587: 1169-78. PMID 19171650 DOI: 10.1113/jphysiol.2008.168005  0.96
2009 Braun M, Ramracheya R, Johnson PR, Rorsman P. Exocytotic properties of human pancreatic beta-cells. Annals of the New York Academy of Sciences. 1152: 187-93. PMID 19161389 DOI: 10.1111/j.1749-6632.2008.03992.x  0.96
2009 Sumara G, Formentini I, Collins S, Sumara I, Windak R, Bodenmiller B, Ramracheya R, Caille D, Jiang H, Platt KA, Meda P, Aebersold R, Rorsman P, Ricci R. Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis. Cell. 136: 235-48. PMID 19135240 DOI: 10.1016/j.cell.2008.11.018  0.96
2009 Girard CA, Wunderlich FT, Shimomura K, Collins S, Kaizik S, Proks P, Abdulkader F, Clark A, Ball V, Zubcevic L, Bentley L, Clark R, Church C, Hugill A, Galvanovskis J, ... ... Rorsman P, et al. Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes. The Journal of Clinical Investigation. 119: 80-90. PMID 19065048 DOI: 10.1172/JCI35772  0.96
2009 Karanauskaite J, Hoppa MB, Braun M, Galvanovskis J, Rorsman P. Quantal ATP release in rat beta-cells by exocytosis of insulin-containing LDCVs. PflüGers Archiv : European Journal of Physiology. 458: 389-401. PMID 19018564 DOI: 10.1007/s00424-008-0610-6  0.96
2009 Mårtensson UE, Salehi SA, Windahl S, Gomez MF, Swärd K, Daszkiewicz-Nilsson J, Wendt A, Andersson N, Hellstrand P, Grände PO, Owman C, Rosen CJ, Adamo ML, Lundquist I, Rorsman P, et al. Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice. Endocrinology. 150: 687-98. PMID 18845638 DOI: 10.1210/en.2008-0623  0.96
2009 Hanna ST, Pigeau GM, Galvanovskis J, Clark A, Rorsman P, MacDonald PE. Kiss-and-run exocytosis and fusion pores of secretory vesicles in human beta-cells. PflüGers Archiv : European Journal of Physiology. 457: 1343-50. PMID 18795319 DOI: 10.1007/s00424-008-0588-0  0.96
2008 Zehetner J, Danzer C, Collins S, Eckhardt K, Gerber PA, Ballschmieter P, Galvanovskis J, Shimomura K, Ashcroft FM, Thorens B, Rorsman P, Krek W. PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells. Genes & Development. 22: 3135-46. PMID 19056893 DOI: 10.1101/gad.496908  0.96
2008 Rorsman P, Salehi SA, Abdulkader F, Braun M, MacDonald PE. K(ATP)-channels and glucose-regulated glucagon secretion. Trends in Endocrinology and Metabolism: Tem. 19: 277-84. PMID 18771934 DOI: 10.1016/j.tem.2008.07.003  0.96
2008 Wallis RH, Collins SC, Kaisaki PJ, Argoud K, Wilder SP, Wallace KJ, Ria M, Ktorza A, Rorsman P, Bihoreau MT, Gauguier D. Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome. Plos One. 3: e2962. PMID 18698428 DOI: 10.1371/journal.pone.0002962  0.96
2008 Zhang Q, Galvanovskis J, Abdulkader F, Partridge CJ, Göpel SO, Eliasson L, Rorsman P. Cell coupling in mouse pancreatic beta-cells measured in intact islets of Langerhans. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 366: 3503-23. PMID 18632454 DOI: 10.1098/rsta.2008.0110  0.96
2008 Bengtsson M, Hemberg M, Rorsman P, StÃ¥hlberg A. Quantification of mRNA in single cells and modelling of RT-qPCR induced noise. Bmc Molecular Biology. 9: 63. PMID 18631407 DOI: 10.1186/1471-2199-9-63  0.96
2008 Collins SC, Salehi A, Eliasson L, Olofsson CS, Rorsman P. Long-term exposure of mouse pancreatic islets to oleate or palmitate results in reduced glucose-induced somatostatin and oversecretion of glucagon. Diabetologia. 51: 1689-93. PMID 18622593 DOI: 10.1007/s00125-008-1082-0  0.96
2008 Eliasson L, Abdulkader F, Braun M, Galvanovskis J, Hoppa MB, Rorsman P. Novel aspects of the molecular mechanisms controlling insulin secretion. The Journal of Physiology. 586: 3313-24. PMID 18511483 DOI: 10.1113/jphysiol.2008.155317  0.96
2008 Braun M, Ramracheya R, Bengtsson M, Zhang Q, Karanauskaite J, Partridge C, Johnson PR, Rorsman P. Voltage-gated ion channels in human pancreatic beta-cells: electrophysiological characterization and role in insulin secretion. Diabetes. 57: 1618-28. PMID 18390794 DOI: 10.2337/db07-0991  0.96
2008 Speidel D, Salehi A, Obermueller S, Lundquist I, Brose N, Renström E, Rorsman P. CAPS1 and CAPS2 regulate stability and recruitment of insulin granules in mouse pancreatic beta cells. Cell Metabolism. 7: 57-67. PMID 18177725 DOI: 10.1016/j.cmet.2007.11.009  0.96
2008 Renström E, Rorsman P. Regulation of insulin granule exocytosis Pancreatic Beta Cell in Health and Disease. 147-176. DOI: 10.1007/978-4-431-75452-7_9  0.96
2008 Galvanovskis J, Rorsman P, Söderberg B. Probability of Exocytosis in Pancreatic β-Cells: Dependence on Ca2+ Sensing Latency Times, Ca2+ Channel Kinetic Parameters, and Channel Clustering Biosimulation in Drug Development. 299-311. DOI: 10.1002/9783527622672.ch11  0.96
2007 Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science (New York, N.Y.). 318: 1469-72. PMID 17991826 DOI: 10.1126/science.1151710  0.96
2007 Nielsen LB, Ploug KB, Swift P, Ørskov C, Jansen-Olesen I, Chiarelli F, Holst JJ, Hougaard P, Pörksen S, Holl R, de Beaufort C, Gammeltoft S, Rorsman P, Mortensen HB, Hansen L, et al. Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes. European Journal of Endocrinology / European Federation of Endocrine Societies. 156: 663-71. PMID 17535866 DOI: 10.1530/EJE-06-0756  0.96
2007 MacDonald PE, De Marinis YZ, Ramracheya R, Salehi A, Ma X, Johnson PR, Cox R, Eliasson L, Rorsman P. A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans. Plos Biology. 5: e143. PMID 17503968 DOI: 10.1371/journal.pbio.0050143  0.96
2007 Olofsson CS, Collins S, Bengtsson M, Eliasson L, Salehi A, Shimomura K, Tarasov A, Holm C, Ashcroft F, Rorsman P. Long-term exposure to glucose and lipids inhibits glucose-induced insulin secretion downstream of granule fusion with plasma membrane. Diabetes. 56: 1888-97. PMID 17456851 DOI: 10.2337/db06-1150  0.96
2007 MacDonald PE, Rorsman P. The ins and outs of secretion from pancreatic beta-cells: control of single-vesicle exo- and endocytosis. Physiology (Bethesda, Md.). 22: 113-21. PMID 17420302 DOI: 10.1152/physiol.00047.2006  0.96
2007 Zhang Q, Bengtsson M, Partridge C, Salehi A, Braun M, Cox R, Eliasson L, Johnson PR, Renström E, Schneider T, Berggren PO, Göpel S, Ashcroft FM, Rorsman P. R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion. Nature Cell Biology. 9: 453-60. PMID 17369816 DOI: 10.1038/ncb1563  0.96
2007 Braun M, Wendt A, Karanauskaite J, Galvanovskis J, Clark A, MacDonald PE, Rorsman P. Corelease and differential exit via the fusion pore of GABA, serotonin, and ATP from LDCV in rat pancreatic beta cells. The Journal of General Physiology. 129: 221-31. PMID 17296927 DOI: 10.1085/jgp.200609658  0.96
2007 Jeans AF, Oliver PL, Johnson R, Capogna M, Vikman J, Molnár Z, Babbs A, Partridge CJ, Salehi A, Bengtsson M, Eliasson L, Rorsman P, Davies KE. A dominant mutation in Snap25 causes impaired vesicle trafficking, sensorimotor gating, and ataxia in the blind-drunk mouse. Proceedings of the National Academy of Sciences of the United States of America. 104: 2431-6. PMID 17283335 DOI: 10.1073/pnas.0610222104  0.96
2007 Salehi A, Eliasson L, Ma X, Rorsman P, HÃ¥kanson R, Lundquist I. Secretory and electrophysiological characteristics of insulin cells from gastrectomized mice: evidence for the existence of insulinotropic agents in the stomach. Regulatory Peptides. 139: 31-8. PMID 17109976 DOI: 10.1016/j.regpep.2006.10.001  0.96
2006 MacDonald PE, Braun M, Galvanovskis J, Rorsman P. Release of small transmitters through kiss-and-run fusion pores in rat pancreatic beta cells. Cell Metabolism. 4: 283-90. PMID 17011501 DOI: 10.1016/j.cmet.2006.08.011  0.96
2006 Vikman J, Ma X, Hockerman GH, Rorsman P, Eliasson L. Antibody inhibition of synaptosomal protein of 25 kDa (SNAP-25) and syntaxin 1 reduces rapid exocytosis in insulin-secreting cells. Journal of Molecular Endocrinology. 36: 503-15. PMID 16720719 DOI: 10.1677/jme.1.01978  0.96
2006 MacDonald PE, Rorsman P. Oscillations, intercellular coupling, and insulin secretion in pancreatic beta cells. Plos Biology. 4: e49. PMID 16464129 DOI: 10.1371/journal.pbio.0040049  0.96
2006 Taneera J, Rosengren A, Renstrom E, Nygren JM, Serup P, Rorsman P, Jacobsen SE. Failure of transplanted bone marrow cells to adopt a pancreatic beta-cell fate. Diabetes. 55: 290-6. PMID 16443759 DOI: 10.2337/diabetes.55.02.06.db05-1212  0.96
2005 MacDonald PE, Joseph JW, Rorsman P. Glucose-sensing mechanisms in pancreatic beta-cells. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 360: 2211-25. PMID 16321791 DOI: 10.1098/rstb.2005.1762  0.96
2005 MacDonald PE, Eliasson L, Rorsman P. Calcium increases endocytotic vesicle size and accelerates membrane fission in insulin-secreting INS-1 cells. Journal of Cell Science. 118: 5911-20. PMID 16317049 DOI: 10.1242/jcs.02685  0.96
2005 Bengtsson M, StÃ¥hlberg A, Rorsman P, Kubista M. Gene expression profiling in single cells from the pancreatic islets of Langerhans reveals lognormal distribution of mRNA levels. Genome Research. 15: 1388-92. PMID 16204192 DOI: 10.1101/gr.3820805  0.96
2005 Obermüller S, Lindqvist A, Karanauskaite J, Galvanovskis J, Rorsman P, Barg S. Selective nucleotide-release from dense-core granules in insulin-secreting cells. Journal of Cell Science. 118: 4271-82. PMID 16141231 DOI: 10.1242/jcs.02549  0.96
2005 MacDonald PE, Obermüller S, Vikman J, Galvanovskis J, Rorsman P, Eliasson L. Regulated exocytosis and kiss-and-run of synaptic-like microvesicles in INS-1 and primary rat beta-cells. Diabetes. 54: 736-43. PMID 15734850 DOI: 10.2337/diabetes.54.3.736  0.96
2005 Jing X, Li DQ, Olofsson CS, Salehi A, Surve VV, Caballero J, Ivarsson R, Lundquist I, Pereverzev A, Schneider T, Rorsman P, Renström E. CaV2.3 calcium channels control second-phase insulin release. The Journal of Clinical Investigation. 115: 146-54. PMID 15630454 DOI: 10.1172/JCI22518  0.96
2005 Ma X, Zhang Y, Gromada J, Sewing S, Berggren PO, Buschard K, Salehi A, Vikman J, Rorsman P, Eliasson L. Glucagon stimulates exocytosis in mouse and rat pancreatic alpha-cells by binding to glucagon receptors. Molecular Endocrinology (Baltimore, Md.). 19: 198-212. PMID 15459251 DOI: 10.1210/me.2004-0059  0.96
2005 Rorsman P. Insulin secretion: Function and therapy of pancreatic beta-cells in diabetes British Journal of Diabetes and Vascular Disease. 5: 187-191.  0.96
2004 Gromada J, Rorsman P. New insights into the regulation of glucagon secretion by glucagon-like peptide-1. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et MéTabolisme. 36: 822-9. PMID 15655714 DOI: 10.1055/s-2004-826169  0.96
2004 Barg S, Rorsman P. Insulin secretion: a high-affinity Ca2+ sensor after all? The Journal of General Physiology. 124: 623-5. PMID 15572341 DOI: 10.1085/jgp.200409206  0.96
2004 Gromada J, Brock B, Schmitz O, Rorsman P. Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential. Basic & Clinical Pharmacology & Toxicology. 95: 252-62. PMID 15569269 DOI: 10.1111/j.1742-7843.2004.t01-1-pto950502.x  0.96
2004 Gromada J, Ma X, Høy M, Bokvist K, Salehi A, Berggren PO, Rorsman P. ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse alpha-cells. Diabetes. 53: S181-9. PMID 15561909  0.48
2004 Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M. A pancreatic islet-specific microRNA regulates insulin secretion. Nature. 432: 226-30. PMID 15538371 DOI: 10.1038/nature03076  0.96
2004 Olofsson CS, Salehi A, Göpel SO, Holm C, Rorsman P. Palmitate stimulation of glucagon secretion in mouse pancreatic alpha-cells results from activation of L-type calcium channels and elevation of cytoplasmic calcium. Diabetes. 53: 2836-43. PMID 15504963 DOI: 10.2337/diabetes.53.11.2836  0.96
2004 Braun M, Wendt A, Buschard K, Salehi A, Sewing S, Gromada J, Rorsman P. GABAB receptor activation inhibits exocytosis in rat pancreatic beta-cells by G-protein-dependent activation of calcineurin. The Journal of Physiology. 559: 397-409. PMID 15235087 DOI: 10.1113/jphysiol.2004.066563  0.96
2004 Kanno T, Ma X, Barg S, Eliasson L, Galvanovskis J, Göpel S, Larsson M, Renström E, Rorsman P. Large dense-core vesicle exocytosis in pancreatic beta-cells monitored by capacitance measurements. Methods (San Diego, Calif.). 33: 302-11. PMID 15183179 DOI: 10.1016/j.ymeth.2004.01.003  0.96
2004 Hansson K, Ma X, Eliasson L, Czerwiec E, Furie B, Furie BC, Rorsman P, Stenflo J. The first gamma-carboxyglutamic acid-containing contryphan. A selective L-type calcium ion channel blocker isolated from the venom of Conus marmoreus. The Journal of Biological Chemistry. 279: 32453-63. PMID 15155730 DOI: 10.1074/jbc.M313825200  0.96
2004 Sinnegger-Brauns MJ, Hetzenauer A, Huber IG, Renström E, Wietzorrek G, Berjukov S, Cavalli M, Walter D, Koschak A, Waldschütz R, Hering S, Bova S, Rorsman P, Pongs O, Singewald N, et al. Isoform-specific regulation of mood behavior and pancreatic beta cell and cardiovascular function by L-type Ca 2+ channels. The Journal of Clinical Investigation. 113: 1430-9. PMID 15146240 DOI: 10.1172/JCI20208  0.96
2004 Fex M, Olofsson CS, Fransson U, Bacos K, Lindvall H, Sörhede-Winzell M, Rorsman P, Holm C, Mulder H. Hormone-sensitive lipase deficiency in mouse islets abolishes neutral cholesterol ester hydrolase activity but leaves lipolysis, acylglycerides, fat oxidation, and insulin secretion intact. Endocrinology. 145: 3746-53. PMID 15142983 DOI: 10.1210/en.2003-1673  0.96
2004 Olofsson CS, Salehi A, Holm C, Rorsman P. Palmitate increases L-type Ca2+ currents and the size of the readily releasable granule pool in mouse pancreatic beta-cells. The Journal of Physiology. 557: 935-48. PMID 15090611 DOI: 10.1113/jphysiol.2004.066258  0.96
2004 Wendt A, Birnir B, Buschard K, Gromada J, Salehi A, Sewing S, Rorsman P, Braun M. Glucose inhibition of glucagon secretion from rat alpha-cells is mediated by GABA released from neighboring beta-cells. Diabetes. 53: 1038-45. PMID 15047619 DOI: 10.2337/diabetes.53.4.1038  0.96
2004 Ashcroft FM, Rorsman P. Molecular defects in insulin secretion in type-2 diabetes. Reviews in Endocrine & Metabolic Disorders. 5: 135-42. PMID 15041789 DOI: 10.1023/B:REMD.0000021435.87776.a7  0.96
2004 Göpel S, Zhang Q, Eliasson L, Ma XS, Galvanovskis J, Kanno T, Salehi A, Rorsman P. Capacitance measurements of exocytosis in mouse pancreatic alpha-, beta- and delta-cells within intact islets of Langerhans. The Journal of Physiology. 556: 711-26. PMID 14966302 DOI: 10.1113/jphysiol.2003.059675  0.96
2004 Braun M, Wendt A, Birnir B, Broman J, Eliasson L, Galvanovskis J, Gromada J, Mulder H, Rorsman P. Regulated exocytosis of GABA-containing synaptic-like microvesicles in pancreatic beta-cells. The Journal of General Physiology. 123: 191-204. PMID 14769845 DOI: 10.1085/jgp.200308966  0.96
2004 Ashcroft F, Rorsman P. Type 2 diabetes mellitus: not quite exciting enough? Human Molecular Genetics. 13: R21-31. PMID 14734629 DOI: 10.1093/hmg/ddh066  0.96
2003 Schulla V, Renström E, Feil R, Feil S, Franklin I, Gjinovci A, Jing XJ, Laux D, Lundquist I, Magnuson MA, Obermüller S, Olofsson CS, Salehi A, Wendt A, Klugbauer N, ... ... Rorsman P, et al. Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice. The Embo Journal. 22: 3844-54. PMID 12881419 DOI: 10.1093/emboj/cdg389  0.96
2003 Rorsman P, Renström E. Insulin granule dynamics in pancreatic beta cells Diabetologia. 46: 1029-1045. PMID 12879249 DOI: 10.1007/s00125-003-1153-1  0.96
2003 Olsen HL, Hoy M, Zhang W, Bertorello AM, Bokvist K, Capito K, Efanov AM, Meister B, Thams P, Yang SN, Rorsman P, Berggren PO, Gromada J. Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells. Proceedings of the National Academy of Sciences of the United States of America. 100: 5187-92. PMID 12700357 DOI: 10.1073/pnas.0931282100  0.96
2003 Høy M, Olsen HL, Andersen HS, Bokvist K, Buschard K, Hansen J, Jacobsen P, Petersen JS, Rorsman P, Gromada J. Imidazoline NNC77-0074 stimulates insulin secretion and inhibits glucagon release by control of Ca2+-dependent exocytosis in pancreatic α- and β-cells European Journal of Pharmacology. 466: 213-221. PMID 12679159 DOI: 10.1016/S0014-2999(03)01537-1  0.96
2003 Eliasson L, Ma X, Renström E, Barg S, Berggren PO, Galvanovskis J, Gromada J, Jing X, Lundquist I, Salehi A, Sewing S, Rorsman P. SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells. The Journal of General Physiology. 121: 181-97. PMID 12601083 DOI: 10.1085/jgp.20028707  0.96
2002 Kanno T, Rorsman P, Göpel SO. Glucose-dependent regulation of rhythmic action potential firing in pancreatic β-cells by KATP-channel modulation Journal of Physiology. 545: 501-507. PMID 12456829 DOI: 10.1113/jphysiol.2002.031344  0.96
2002 Gromada J, Bokvist K, Høy M, Olsen HL, Lindström P, Hansen BS, Gotfredsen CF, Rorsman P, Thomsen MK. Nateglinide, but not repaglinide, stimulates growth hormone release in rat pituitary cells by inhibition of K channels and stimulation of cyclic AMP-dependent exocytosis. European Journal of Endocrinology / European Federation of Endocrine Societies. 147: 133-42. PMID 12088930  0.96
2002 Olofsson CS, Göpel SO, Barg S, Galvanovskis J, Ma X, Salehi A, Rorsman P, Eliasson L. Fast insulin secretion reflects exocytosis of docked granules in mouse pancreatic B-cells. PflüGers Archiv : European Journal of Physiology. 444: 43-51. PMID 11976915 DOI: 10.1007/s00424-002-0781-5  0.96
2002 Kanno T, Göpel SO, Rorsman P, Wakui M. Cellular function in multicellular system for hormone-secretion: Electrophysiological aspect of studies on α-, β- and δ-cells of the pancreatic islet Neuroscience Research. 42: 79-90. PMID 11849727 DOI: 10.1016/S0168-0102(01)00318-2  0.96
2002 Barg S, Eliasson L, Renström E, Rorsman P. A subset of 50 secretory granules in close contact with L-type Ca2+ channels accounts for first-phase insulin secretion in mouse β-cells Diabetes. 51: S74-S82. PMID 11815462  0.96
2002 Renström E, Barg S, Thévenod F, Rorsman P. Sulfonylurea-mediated stimulation of insulin exocytosis via an ATP-sensitive K+ channel-independent action Diabetes. 51: S33-S36. PMID 11815455  0.96
2002 Barg S, Olofsson CS, Schriever-Abeln J, Wendt A, Gebre-Medhin S, Renström E, Rorsman P. Delay between fusion pore opening and peptide release from large dense-core vesicles in neuroendocrine cells Neuron. 33: 287-299. PMID 11804575 DOI: 10.1016/S0896-6273(02)00563-9  0.96
2001 Barg S, Ma X, Eliasson L, Galvanovskis J, Göpel SO, Obermüller S, Platzer J, Renström E, Trus M, Atlas D, Striessnig J, Rorsman P. Fast exocytosis with few Ca(2+) channels in insulin-secreting mouse pancreatic B cells. Biophysical Journal. 81: 3308-23. PMID 11720994 DOI: 10.1016/S0006-3495(01)75964-4  0.96
2001 Gromada J, Høy M, Buschard K, Salehi A, Rorsman P. Somatostatin inhibits exocytosis in rat pancreatic alpha-cells by G(i2)-dependent activation of calcineurin and depriming of secretory granules. The Journal of Physiology. 535: 519-32. PMID 11533141 DOI: 10.1111/j.1469-7793.2001.00519.x  0.96
2001 Barg S, Huang P, Eliasson L, Nelson DJ, Obermüller S, Rorsman P, Thévenod F, Renström E. Priming of insulin granules for exocytosis by granular Cl(-) uptake and acidification. Journal of Cell Science. 114: 2145-54. PMID 11493650  0.96
2001 Gromada J, Høy M, Olsen HL, Gotfredsen CF, Buschard K, Rorsman P, Bokvist K. Gi2 proteins couple somatostatin receptors to low-conductance K+ channels in rat pancreatic α-cells Pflugers Archiv European Journal of Physiology. 442: 19-26. PMID 11374064 DOI: 10.1007/s004240000474  0.96
2001 Larsson-Nyrén G, Sehlin J, Rorsman P, Renström E. Perchlorate stimulates insulin secretion by shifting the gating of L-type Ca2+ currents in mouse pancreatic B-cells towards negative potentials Pflugers Archiv European Journal of Physiology. 441: 587-595. PMID 11294239 DOI: 10.1007/s004240000426  0.96
2000 Göpel SO, Kanno T, Barg S, Weng XG, Gromada J, Rorsman P. Regulation of glucagon release in mouse α-cells by K(ATP) channels and inactivation of TTX-sensitive Na+ channels Journal of Physiology. 528: 509-520. PMID 11060128  0.96
2000 Gopel SO, Kanno T, Barg S, Rorsman P. Patch-clamp characterisation of somatostatin-secreting δ-cells in intact mouse pancreatic islets Journal of Physiology. 528: 497-507. PMID 11060127  0.96
2000 Barg S, Galvanovskis J, Gopel SO, Rorsman P, Eliasson L. Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting α-cells Diabetes. 49: 1500-1510. PMID 10969834  0.96
2000 Høy M, Olsen HL, Bokvist K, Buschard K, Barg S, Rorsman P, Gromada J. Tolbutamide stimulates exocytosis of glucagon by inhibition of a mitochondrial-like ATP-sensitive K+ (K(ATP)) conductance in rat pancreatic A-cells Journal of Physiology. 527: 109-120. PMID 10944174  0.96
2000 Bokvist K, Holmqvist M, Gromada J, Rorsman P. Compound exocytosis in voltage-clamped mouse pancreatic β-cells revealed by carbon fibre amperometry Pflugers Archiv European Journal of Physiology. 439: 634-645. PMID 10764224 DOI: 10.1007/s004240050987  0.96
2000 Rorsman P, Eliasson L, Renström E, Gromada J, Barg S, Göpel S. The cell physiology of biphasic insulin secretion News in Physiological Sciences. 15: 72-77.  0.96
1999 Rorsman P, Renström E. Glutamate primes the pump Nature. 402: 595-596. PMID 10604461 DOI: 10.1038/45110  0.96
1999 Göpel S, Kanno T, Barg S, Galvanovskis J, Rorsman P. Voltage-gated and resting membrane currents recorded from B-cells in intact mouse pancreatic islets Journal of Physiology. 521: 717-728. PMID 10601501  0.96
1999 Göpel SO, Kanno T, Barg S, Eliasson L, Galvanovskis J, Renström E, Rorsman P. Activation of Ca2+-dependent K+ channels contributes to rhythmic firing of action potentials in mouse pancreatic β cells Journal of General Physiology. 114: 759-769. PMID 10578013 DOI: 10.1085/jgp.114.6.759  0.96
1999 Bokvist K, Olsen HL, Høy M, Gotfredsen CF, Holmes WF, Buschard K, Rorsman P, Gromada J. Characterisation of sulphonylurea and ATP-regulated K+ channels in rat pancreatic A-cells Pflugers Archiv European Journal of Physiology. 438: 428-436. PMID 10519134 DOI: 10.1007/s004240051058  0.96
1999 Gromada J, Høy M, Renström E, Bokvist K, Eliasson L, Göpel S, Rorsman P. CaM kinase II-dependent mobilization of secretory granules underlies acetylcholine-induced stimulation of exocytosis in mouse pancreatic B-cells Journal of Physiology. 518: 745-759. PMID 10420011 DOI: 10.1111/j.1469-7793.1999.0745p.x  0.96
1999 Barg S, Renstrom E, Berggren PO, Bertorello A, Bokvist K, Braun M, Eliasson L, Holmes WE, Kohler M, Rorsman P, Thevenod F. The stimulatory action of tolbutamide on Ca2+-dependent exocytosis in pancreatic β cells is mediated by a 65-kDa mdr-like P-glycoprotein Proceedings of the National Academy of Sciences of the United States of America. 96: 5539-5544. PMID 10318919 DOI: 10.1073/pnas.96.10.5539  0.96
1999 Gall D, Gromada J, Susa I, Rorsman P, Herchuelz A, Bokvist K. Significance of Na/Ca exchange for Ca2+ buffering and electrical activity in mouse pancreatic β-cells Biophysical Journal. 76: 2018-2028. PMID 10096898  0.96
1999 Mulder H, Holst LS, Svensson H, Degerman E, Sundler F, Ahrén B, Rorsman P, Holm C. Hormone-sensitive lipase, the rate-limiting enzyme in triglyceride hydrolysis, is expressed and active in β-cells Diabetes. 48: 228-232. PMID 9892250 DOI: 10.2337/diabetes.48.1.228  0.96
1999 Wiser O, Trus M, Hernandez A, Renstrom E, Barg S, Rorsman P, Atlas D. The voltage sensitive Lc-type Ca2+ channel is functionally coupled to the exocytotic machinery Proceedings of the National Academy of Sciences of the United States of America. 96: 248-253. PMID 9874804 DOI: 10.1073/pnas.96.1.248  0.96
1998 Fuhlendorff J, Rorsman P, Kofod H, Brand CL, Rolin B, MacKay P, Shymko R, Carr RD. Stimulation of insulin release by repaglinide and glibenclamide involves both common and distinct processes. Diabetes. 47: 345-51. PMID 9519738 DOI: 10.2337/diabetes.47.3.345  0.96
1998 Gromada J, Holst JJ, Rorsman P. Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1 Pflugers Archiv European Journal of Physiology. 435: 583-594. PMID 9479010 DOI: 10.1007/s004240050558  0.96
1998 Gromada J, Bokvist K, Ding WG, Holst JJ, Nielsen JH, Rorsman P. Glucagon-like peptide 1(7-36) amide stimulates exocytosis in human pancreatic β-cells by both proximal and distal regulatory steps in stimulus- secretion coupling Diabetes. 47: 57-65. PMID 9421375  0.96
1997 Eliasson L, Renström E, Ding WG, Proks P, Rorsman P. Rapid ATP-dependent priming of secretory granules precedes Ca2+-induced exocytosis in mouse pancreatic B-cells Journal of Physiology. 503: 399-412. PMID 9306281 DOI: 10.1111/j.1469-7793.1997.399bh.x  0.96
1997 Gromada J, Bokvist K, Ding WG, Barg S, Buschard K, Renström E, Rorsman P. Adrenaline stimulates glucagon secretion in pancreatic A-cells by increasing the Ca2+ current and the number of granules close to the L-type Ca2+ channels Journal of General Physiology. 110: 217-228. PMID 9276750 DOI: 10.1085/jgp.110.3.217  0.96
1997 Rorsman P. Electrophysiological studies of insulin secretion, physiology and pathophysiology | Elektrofysiologiska undersökningar av insulinfrisättningens fysiologi och patofysiologi Nordisk Medicin. 112: 164-168. PMID 9273507  0.96
1997 Rorsman P, Eliasson L, Renstrom E. Components of insulin secretion: Lessons to be learnt from capacitance Japanese Journal of Physiology. 47: S21. PMID 9266316  0.96
1997 Gromada J, Ding WG, Barg S, Renström E, Rorsman P. Multisite regulation of insulin secretion by cAMP-increasing agonists: Evidence that glucagon-like peptide 1 and glucagon act via distinct receptors Pflugers Archiv European Journal of Physiology. 434: 515-524. PMID 9242714 DOI: 10.1007/s004240050431  0.96
1997 Renström E, Eliasson L, Rorsman P. Protein kinase A-dependent and -independent stimulation of exocytosis by cAMP in mouse pancreatic B-cells Journal of Physiology. 502: 105-118. PMID 9234200 DOI: 10.1111/j.1469-7793.1997.105bl.x  0.96
1997 Rorsman P. The pancreatic beta-cell as a fuel sensor: An electrophysiologist's viewpoint Diabetologia. 40: 487-495. PMID 9165215 DOI: 10.1007/s001250050706  0.96
1997 Ding WG, Renström E, Rorsman P, Buschard K, Gromada J. Glucagon-like peptide I and glucose-dependent insulinotropic polypeptide stimulate Ca2+-induced secretion in rat α-cells by a protein kinase A- mediated mechanism Diabetes. 46: 792-800. PMID 9133546  0.96
1997 Gilon P, Yakel J, Gromada J, Zhu Y, Henquin JC, Rorsman P. G protein-dependent inhibition of L-type Ca2+ currents by acetylcholine in mouse pancreatic B-cells. The Journal of Physiology. 499: 65-76. PMID 9061640  0.96
1996 Proks P, Eliasson L, Ämmälä C, Rorsman P, Ashcroft FM. Ca2+- and GTP-dependent exocytosis in mouse pancreatic β-cells involves both common and distinct steps Journal of Physiology. 496: 255-264. PMID 8910213  0.96
1996 Gromada J, Rorsman P. Molecular mechanism underlying glucagon-like peptide 1 induced calcium mobilization from internal stores in insulin-secreting βTC3 cells Acta Physiologica Scandinavica. 157: 349-351. PMID 8830891  0.96
1996 Renström E, Ding WG, Bokvist K, Rorsman P. Neurotransmitter-induced inhibition of exocytosis in insulin-secreting β cells by activation of calcineurin Neuron. 17: 513-522. PMID 8816714 DOI: 10.1016/S0896-6273(00)80183-X  0.96
1996 Renström E, Eliasson L, Bokvist K, Rorsman P. Cooling inhibits exocytosis in single mouse pancreatic B-cells by suppression of granule mobilization Journal of Physiology. 494: 41-52. PMID 8814605  0.96
1996 Malaisse WJ, Lebrun P, Pirotte B, Van Poelje PD, Viñambres C, Villanueva-Peñacarillo ML, Valverde I, Gäbel J, Rorsman P. The riddle of formycin A insulinotropic action Biochemical and Molecular Medicine. 57: 47-63. PMID 8812726 DOI: 10.1006/bmme.1996.0008  0.96
1996 Eliasson L, Proks P, Ammälä C, Ashcroft FM, Bokvist K, Renström E, Rorsman P, Smith PA. Endocytosis of secretory granules in mouse pancreatic beta-cells evoked by transient elevation of cytosolic calcium. The Journal of Physiology. 493: 755-67. PMID 8799897  0.96
1996 Gromada J, Dissing S, Rorsman P. Desensitization of glucagon-like peptide 1 receptors in insulin-secreting βTC3 cells: Role of PKA-independent mechanisms British Journal of Pharmacology. 118: 769-775. PMID 8762106  0.96
1996 Eliasson L, Renström E, Ämmälä C, Berggren PO, Bertorello AM, Bokvist K, Chibalin A, Deeney JT, Flatt PR, Gäbel J, Gromada J, Larsson O, Lindström P, Rhodes CJ, Rorsman P. PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic β cells Science. 271: 813-815. PMID 8628999  0.96
1996 Lebrun P, Renström E, Antoine MH, Bokvist K, Holmquist M, Rorsman P, Malaisse WJ. Dynamics of the cationic, bioelectrical and secretory responses to formycin A in pancreatic islet cells Pflugers Archiv European Journal of Physiology. 431: 353-362. PMID 8584428  0.96
1995 Bokvist K, Eliasson L, Ämmälä C, Renström E, Rorsman P. Co-localization of L-type Ca2+ channels and insulin-containing secretory granules and its significance for the initiation of exocytosis in mouse pancreatic B-cells Embo Journal. 14: 50-57. PMID 7828595  0.96
1995 Gromada J, Dissing S, Bokvist K, Renström E, Frøkjser-Jensen J, Wulff BS, Rorsman P. Glucagon-like peptide I increases cytoplasmic calcium in insulin-secreting βTC3-cells by enhancement of intracellular calcium mobilization Diabetes. 44: 767-774. PMID 7789644  0.96
1995 Gromada J, Rorsman P, Dissing S, Wulff BS. Stimulation of cloned human glucagon-like peptide 1 receptor expressed in HEK 293 cells induces cAMP-dependent activation of calcium-induced calcium release Febs Letters. 373: 182-186. PMID 7589461 DOI: 10.1016/0014-5793(95)01070-U  0.96
1994 Best L, Ammala C, Rorsman P, Tomlinson S. Intracellular pH, cytosolic calcium concentration and electrical activity in RINm5F insulinoma cells Bba - Biomembranes. 1192: 107-111. PMID 8204639 DOI: 10.1016/0005-2736(94)90149-X  0.96
1994 Ämmälä C, Eliasson L, Bokvist K, Berggren PO, Honkanen RE, Sjöholm A, Rorsman P. Activation of protein kinases and inhibition of protein phosphatases play a central role in the regulation of exocytosis in mouse pancreatic β cells Proceedings of the National Academy of Sciences of the United States of America. 91: 4343-4347. PMID 8183910  0.96
1994 Ashcroft FM, Proks P, Smith PA, Ammälä C, Bokvist K, Rorsman P. Stimulus-secretion coupling in pancreatic beta cells. Journal of Cellular Biochemistry. 55: 54-65. PMID 7929618 DOI: 10.1002/jcb.240550007  0.96
1994 Ekmehag B, Persson B, Rorsman P, Rorsman H. Demonstration of voltage-dependent and TTX-sensitive Na(+)-channels in human melanocytes Pigment Cell Research / Sponsored by the European Society For Pigment Cell Research and the International Pigment Cell Society. 7: 333-338. PMID 7886006  0.96
1994 Malaisse WJ, Conget I, Sener A, Rorsman P. Insulinotropic action of AICA riboside. II. Secretory, metabolic and cationic aspects Diabetes Research. 25: 25-37. PMID 7648779  0.96
1994 Rorsman P, Bokvist K, Ammala CD, Eliasson L, Renstrom E, Gabel J. Ion channels, electrical activity and insulin secretion Diabete Et Metabolisme. 20: 138-145. PMID 7528694  0.96
1993 Ämmälä C, Bokvist K, Larsson O, Berggren PO, Rorsman P. Demonstration of a novel apamin-insensitive calcium-activated K+ channel in mouse pancreatic B cells PflüGers Archiv European Journal of Physiology. 422: 443-448. PMID 8474849 DOI: 10.1007/BF00375069  0.96
1993 Sjöholm A, Arkhammar P, Welsh N, Bokvist K, Rorsman P, Hallberg A, Nilsson T, Welsh M, Berggren PO. Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells an effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity Journal of Clinical Investigation. 92: 1910-1917. PMID 8408643  0.96
1993 Larsson O, Ammala C, Bokvist K, Fredholm B, Rorsman P. Stimulation of the K(ATP) channel by adp and diazoxide requires nucleotide hydrolysis in mouse pancreatic β-cells Journal of Physiology. 463: 349-365. PMID 8246187  0.96
1993 Ammala C, Eliasson L, Bokvist K, Larsson O, Ashcroft FM, Rorsman P. Exocytosis elicited by action potentials and voltage-clamp calcium currents in individual mouse pancreatic B-cells Journal of Physiology. 472: 665-688. PMID 8145165 DOI: 10.1113/jphysiol.1993.sp019966  0.96
1993 Juntti-Berggren L, Larsson O, Rorsman P, Ämmälä C, Bokvist K, Wåhlander K, Nicotera P, Dypbukt J, Orrenius S, Hallberg A, Berggren PO. Increased activity of L-type Ca2+ channels exposed to serum from patients with type I diabetes Science. 261: 86-90. PMID 7686306  0.96
1993 Ämmälä C, Ashcroft FM, Rorsman P. Calcium-independent potentiation of insulin release by cyclic AMP in single β-cells Nature. 363: 356-358. PMID 7684514  0.96
1993 Best L, Ammala C, Rorsman P. Evidence for an electrogenic lactate conductance in mouse β-ells and RINm5F insulinoma cells Journal of Physiology. 467: 253P.  0.96
1992 Rorsman P, Ämmälä C, Berggren PO, Bokvist K, Larsson O. Cytoplasmic calcium transients due to single action potentials and voltage-clamp depolarizations in mouse pancreatic B-cells Embo Journal. 11: 2877-2884. PMID 1639061  0.96
1992 Islam MS, Rorsman P, Berggren PO. Ca2+-induced Ca2+ release in insulin-secreting cells Febs Letters. 296: 287-291. PMID 1537406 DOI: 10.1016/0014-5793(92)80306-2  0.96
1992 Juntti-Berggren L, Rorsman P, Siffert W, Berggren PO. Intracellular pH and the stimulus-secretion coupling in insulin-producing RINm5F cells Biochemical Journal. 287: 59-66. PMID 1417791  0.96
1992 Ämmälä C, Berggren PO, Bokvist K, Rorsman P. Inhibition of L-type calcium channels by internal GTP [γS] in mouse pancreatic β cells PflüGers Archiv European Journal of Physiology. 420: 72-77. PMID 1313169 DOI: 10.1007/BF00378643  0.96
1992 Kindmark H, Kohler M, Efendic S, Rorsman P, Larsson o, Berggren PO. Protein kinase C activity affects glucose-induced oscillations in cytoplasmic free Ca2+ in the pancreatic B-cell Febs Letters. 305: 166. DOI: 10.1016/0014-5793(92)80483-W  0.96
1992 Kindmark H, Kohler M, Efendic S, Rorsman P, Larsson o, Berggren PO. Protein kinase C activity affects glucose-induced oscillations in cytoplasmic free Ca2+ in the pancreatic B-cell Febs Letters. 305: 166.  0.96
1991 Ämmälä C, Bokvist K, Galt S, Rorsman P. Inhibition of ATP-regulated K+-channels by a photoactivatable ATP-analogue in mouse pancreatic β-cells Bba - Molecular Cell Research. 1092: 347-349. PMID 2049403 DOI: 10.1016/S0167-4889(97)90011-2  0.96
1991 Rorsman P, Ashcrof FM, Berggren PO. Regulation of glucagon release from pancreatic A-cells Biochemical Pharmacology. 41: 1783-1790. PMID 2039536 DOI: 10.1016/0006-2952(91)90116-M  0.96
1991 Kindmark H, Köhler M, Nilsson T, Arkhammar P, Wiechel KL, Rorsman P, Efendić S, Berggren PO. Measurements of cytoplasmic free Ca2+ concentration in human pancreatic islets and insulinoma cells Febs Letters. 291: 310-314. PMID 1936280 DOI: 10.1016/0014-5793(91)81309-V  0.96
1991 Ämmälä C, Larsson O, Berggren PO, Bokvist K, Juntti-Berggren L, Kindmark H, Rorsman P. Inositol trisphosphate-dependent periodic activation of a Ca2+-activated K+ conductance in glucose-stimulated pancreatic β-cells Nature. 353: 849-852. PMID 1719424  0.96
1991 Rorsman P, Fredholm BB. [Ion channels--the molecular background of neural transmission]. LäKartidningen. 88: 2868-77. PMID 1716716  0.96
1991 Ahren B, Berggren PO, Rorsman P, Ostenson CG, Efendic S. Neuropeptides in the regulation of islet hormone secretion - localization, effects and mode of action Advances in Experimental Medicine and Biology. 291: 129-142. PMID 1681685  0.96
1991 Juntti-Berggren L, Arkhammar P, Nilsson T, Rorsman P, Berggren PO. Glucose-induced increase in cytoplasmic pH in pancreatic β-cells is mediated by Na+/H+ exchange, an effect not dependent on protein kinase C Journal of Biological Chemistry. 266: 23537-23541. PMID 1660875  0.96
1991 Bokvist K, Ämmälä C, Berggren PO, Rorsman P, Wåhlander K. Alpha2-adrenoreceptor stimulation does not inhibit L-type calcium channels in mouse pancreatic β-cells Bioscience Reports. 11: 147-157. PMID 1659917 DOI: 10.1007/BF01182483  0.96
1991 Islam MS, Nilsson T, Rorsman P, Berggren PO. Interaction with the inositol 1,4,5-trisphosphate receptor promotes Ca2+ sequestration in permeabilised insulin-secreting cells Febs Letters. 288: 27-29. PMID 1652478 DOI: 10.1016/0014-5793(91)80995-F  0.96
1990 Smith PA, Ashcroft FM, Rorsman P. Simultaneous recordings of glucose dependent electrical activity and ATP-regulated K(+)-currents in isolated mouse pancreatic beta-cells. Febs Letters. 261: 187-90. PMID 2407553 DOI: 10.1016/0014-5793(90)80667-8  0.96
1990 Bokvist K, Rorsman P, Smith PA. Block of ATP-regulated and Ca2(+)-activated K+ channels in mouse pancreatic beta-cells by external tetraethylammonium and quinine. The Journal of Physiology. 423: 327-42. PMID 2201761  0.96
1990 Bokvist K, Rorsman P, Smith PA. Effects of external tetraethylammonium ions and quinine on delayed rectifying K+ channels in mouse pancreatic beta-cells. The Journal of Physiology. 423: 311-25. PMID 2201760  0.96
1990 Smith PA, Bokvist K, Arkhammar P, Berggren PO, Rorsman P. Delayed rectifying and calcium-activated K+ channels and their significance for action potential repolarization in mouse pancreatic beta-cells. The Journal of General Physiology. 95: 1041-59. PMID 2197368  0.96
1990 Rorsman P, Berggren PO, Smith PA. Glucose in glucagon release. Nature. 344: 716. PMID 2184365 DOI: 10.1038/344716b0  0.64
1989 Smith PA, Bokvist K, Rorsman P. Demonstration of A-currents in pancreatic islet cells. PflüGers Archiv : European Journal of Physiology. 413: 441-3. PMID 2648325 DOI: 10.1007/BF00584497  0.96
1989 Rorsman P, Berggren PO, Bokvist K, Ericson H, Möhler H, Ostenson CG, Smith PA. Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channels. Nature. 341: 233-6. PMID 2550826 DOI: 10.1038/341233a0  0.96
1989 Smith PA, Rorsman P, Ashcroft FM. Modulation of dihydropyridine-sensitive Ca2+ channels by glucose metabolism in mouse pancreatic beta-cells. Nature. 342: 550-3. PMID 2479839 DOI: 10.1038/342550a0  0.96
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