David C. Zappulla, Ph.D.
Affiliations: | 2008-2017 | Department of Biology | Johns Hopkins University, Baltimore, MD |
| 2017-2018 | Department of Molecular Biology & Genetics | Johns Hopkins University, Baltimore, MD | |
| 2018- | Department of Biological Sciences | Lehigh University, Bethlehem, PA, United States |
Area:
telomerase, telomeres, silencing, dna replication, yeast, RNA, RNP, ncRNAWebsite:
https://www.lehigh.edu/~inbios/Faculty/Zappulla.htmlGoogle:
"David Zappulla"Children
Sign in to add trainee| Sean Li Gao | grad student | 2012 | Johns Hopkins |
| Erin Gunter-Kirkby | grad student | 2012 | Johns Hopkins |
| Kevin J. Lebo | grad student | 2015 | Johns Hopkins |
| Karen E. McMurdie | grad student | 2016 | Johns Hopkins |
| Melissa A. Mefford | grad student | 2016 | Johns Hopkins (Chemistry Tree) |
| Rachel O. Niederer | grad student | 2016 | Johns Hopkins |
| Evan P. Hass | grad student | 2017 | Johns Hopkins |
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Publications
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| Mefford MA, Hass EP, Zappulla DC. (2020) A 4-base pair core-enclosing helix in telomerase RNA is essential for activity and for binding to the TERT catalytic protein subunit. Molecular and Cellular Biology |
| Zappulla DC. (2020) Yeast Telomerase RNA Flexibly Scaffolds Protein Subunits: Results and Repercussions. Molecules (Basel, Switzerland). 25 |
| Hass EP, Zappulla DC. (2020) Repositioning the Sm-Binding Site in Telomerase RNA Reveals RNP Organizational Flexibility and Sm-Directed 3'-End Formation. Non-Coding Rna. 6 |
| Chen H, Xue J, Churikov D, et al. (2017) Structural Insights into Yeast Telomerase Recruitment to Telomeres. Cell |
| Niederer RO, Hass EP, Zappulla DC. (2017) Long Noncoding RNAs in the Yeast S. cerevisiae. Advances in Experimental Medicine and Biology. 1008: 119-132 |
| Niederer RO, Papadopoulos N, Zappulla DC. (2016) Identification of novel noncoding transcripts in telomerase-negative yeast using RNA-seq. Scientific Reports. 6: 19376 |
| Mefford MA, Zappulla DC. (2015) Physical connectivity mapping by circular permutation of human telomerase RNA reveals new regions critical for activity and processivity. Molecular and Cellular Biology |
| Hass EP, Zappulla DC. (2015) The Ku subunit of telomerase binds Sir4 to recruit telomerase to lengthen telomeres in S. cerevisiae. Elife. 4 |
| Niederer RO, Zappulla DC. (2015) Refined secondary-structure models of the core of yeast and human telomerase RNAs directed by SHAPE. Rna (New York, N.Y.). 21: 1053 |
| Lebo KJ, Niederer RO, Zappulla DC. (2015) A second essential function of the Est1-binding arm of yeast telomerase RNA. Rna (New York, N.Y.). 21: 862-76 |