Douglas Lowell Theobald, Ph.D.

Affiliations: 
2007- Biochemistry Brandeis University, Waltham, MA, United States 
Area:
Telomeres, molecular evolution, structural bioinformatics, superposition, rhodopsin, bacteriorhodopsin, lactate dehydrogenase, malate dehydrogenase
Website:
http://theobald.brandeis.edu/
Google:
"Douglas Theobald"
Cross-listing: Evolution Tree

Parents

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Steve C. Schultz grad student 1994-2001 CU Boulder (Evolution Tree)
 (Crystallographic and thermodynamic studies of ssDNA sequence discrimination with the Oxytricha nova telomere end -binding protein.)
Deborah S. Wuttke post-doc 2001-2006 CU Boulder
Christopher Miller post-doc 2006-2007 Brandeis (Chemistry Tree)

Children

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Nathaniel Lazar research assistant 2008-2010 Brandeis (Evolution Tree)
Marcus R. Kelly research assistant 2009-2011 Brandeis (Evolution Tree)
Adam M. Drake research assistant 2010-2013 Brandeis (Evolution Tree)
Joseph R. Jacobowitz research assistant 2012-2014 Brandeis
Michelle Yen Fry research assistant 2013-2014 Brandeis (Evolution Tree)
Changhan Xu research assistant 2015-2017 Brandeis (Evolution Tree)
Miriam Hood research assistant 2015-2018 Brandeis (Evolution Tree)
Jacob D. Wirth grad student 2014- Brandeis (Evolution Tree)
Michael Sennett grad student 2018- Brandeis (Evolution Tree)
Simon Olsson grad student 2012-2012 Brandeis (Evolution Tree)
Jeffrey I. Boucher grad student 2008-2013 Brandeis (Evolution Tree)
Phillip A. Steindel grad student 2008-2014 Brandeis
Kristine Ann Mackin grad student 2010-2014 Brandeis
Erin Devine grad student 2011-2015 Brandeis (Evolution Tree)
Richard A. Roy grad student 2012-2018 Brandeis (Evolution Tree)
Brian Clifford Beckett grad student 2013-2019 Brandeis (Evolution Tree)
Christoffer H. Norn grad student 2016-2019 Lund University, Sweden (Evolution Tree)

Collaborators

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Christopher Miller collaborator 2007- Brandeis (Chemistry Tree)
Paul A. Garrity collaborator 2009- Brandeis (Neurotree)
Jeff Gelles collaborator 2010- Brandeis (Chemistry Tree)
Nikolaus Grigorieff collaborator 2011- Brandeis (Evolution Tree)
Thomas Hamelryck collaborator 2011- Copenhagen University (Computational Biology Tree)
Kantilal Vardichand Mardia collaborator 2011- University of Leeds (Evolution Tree)
Dorothee Kern collaborator 2012- Brandeis
Daniel D. Oprian collaborator 2012- Brandeis (Neurotree)
BETA: Related publications

Publications

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Wirth JD, Boucher JI, Jacobowitz JR, et al. (2018) Functional and Structural Resilience of the Active Site Loop in the Evolution of Plasmodium Lactate Dehydrogenase. Biochemistry
Lamarche LB, Kumar RP, Trieu MM, et al. (2017) Purification and Characterization of RhoPDE, a Retinylidene/Phosphodiesterase Fusion Protein and Potential Optogenetics Tool from the Choanoflagellate Salpingoeca rosetta. Biochemistry
Trieu MM, Devine EL, Lamarche LB, et al. (2017) Expression, Purification, and Spectral Tuning of RhoGC, a Retinylidene/Guanylyl Cyclase Fusion Protein and Optogenetics Tool from the Aquatic Fungus Blastocladiella emersonii. The Journal of Biological Chemistry
Nguyen V, Wilson C, Hoemberger M, et al. (2016) Evolutionary drivers of thermoadaptation in enzyme catalysis. Science (New York, N.Y.)
Devine EL, Theobald DL, Oprian DD. (2016) Relocating the active-site lysine in rhodopsin: 2. Evolutionary intermediates. Biochemistry
Theobald DL. (2016) Presenilin adopts the ClC channel fold. Protein Science : a Publication of the Protein Society
Steindel PA, Chen EH, Wirth JD, et al. (2016) Gradual neofunctionalization in the convergent evolution of trichomonad lactate and malate dehydrogenases. Protein Science : a Publication of the Protein Society
Wilson C, Agafonov RV, Hoemberger M, et al. (2015) Kinase dynamics. Using ancient protein kinases to unravel a modern cancer drug's mechanism. Science (New York, N.Y.). 347: 882-6
Boucher JI, Jacobowitz JR, Beckett BC, et al. (2014) An atomic-resolution view of neofunctionalization in the evolution of apicomplexan lactate dehydrogenases. Elife. 3
Mackin KA, Roy RA, Theobald DL. (2014) An empirical test of convergent evolution in rhodopsins. Molecular Biology and Evolution. 31: 85-95
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