Dorothee Kern, Ph.D.

Affiliations: 
Biochemistry Brandeis University, Waltham, MA, United States 
Area:
enzymology, NMR
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"Dorothee Kern"
Cross-listing: Chemistry Tree

Parents

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Gunter S. Fischer grad student 1989-1994 Brandeis (Chemistry Tree)
David E. Wemmer post-doc 1995-1998 UC Berkeley (Chemistry Tree)

Children

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Daryl A. Bosco grad student 2004 Brandeis (Chemistry Tree)
Alexandra K. Gardino grad student 2005 Brandeis
Vu T. Thai grad student 2007 Brandeis
Wladimir Labeikovsky grad student 2008 Brandeis
Janice Velos grad student 2009 Brandeis
S. J. Kerns grad student 2010 Brandeis
Dimitar V. Pachov grad student 2010 Brandeis
Aleksandr Milshteyn grad student 2011 Brandeis
Katherine Henzler-Wildman post-doc 2003-2008 Brandeis (Chemistry Tree)
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Publications

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Otten R, Pádua RAP, Bunzel HA, et al. (2020) How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science (New York, N.Y.)
Hoemberger M, Pitsawong W, Kern D. (2020) Cumulative mechanism of several major imatinib-resistant mutations in Abl kinase. Proceedings of the National Academy of Sciences of the United States of America
Hadzipasic A, Wilson C, Nguyen V, et al. (2020) Ancient origins of allosteric activation in a Ser-Thr kinase. Science (New York, N.Y.). 367: 912-917
Stiller JB, Kerns SJ, Hoemberger M, et al. (2019) Probing the Transition State in Enzyme Catalysis by High-Pressure NMR Dynamics. Nature Catalysis. 2: 726-734
Zorba A, Nguyen V, Koide A, et al. (2019) Allosteric modulation of a human protein kinase with monobodies. Proceedings of the National Academy of Sciences of the United States of America
Pádua RAP, Sun Y, Marko I, et al. (2018) Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2. Nature Communications. 9: 4507
Pitsawong W, Buosi V, Otten R, et al. (2018) Dynamics of human protein kinase Aurora A linked to drug selectivity. Elife. 7
Otten R, Liu L, Kenner LR, et al. (2018) Rescue of conformational dynamics in enzyme catalysis by directed evolution. Nature Communications. 9: 1314
Pitsawong W, Buosi V, Otten R, et al. (2018) Author response: Dynamics of human protein kinase Aurora A linked to drug selectivity Elife
Nguyen V, Wilson C, Hoemberger M, et al. (2016) Evolutionary drivers of thermoadaptation in enzyme catalysis. Science (New York, N.Y.)
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