Lu Chen, Ph.D.
Affiliations: | 2021- | Fox Chase Cancer Center, Philadelphia |
Area:
telomere and telomerase, RNA biology, cancer and agingWebsite:
www.luchenlab.orgGoogle:
"https://scholar.google.com/citations?user=q7rrWCAAAAAJ&hl=en"Cross-listing: Cell Biology Tree
Parents
Sign in to add mentor| Joan W. Conaway | grad student | 2008-2013 | University of Kansas Medical Center (Cell Biology Tree) |
| Steven E. Artandi | post-doc | 2013-2021 | Stanford |
Children
Sign in to add trainee| Julia Hoopman | grad student | 2023- | Lewis Katz School of Medicine at Temple University (Cell Biology Tree) |
| Grigory Matveev | grad student | 2023- | Moscow Institute of Physics and Technology (Cell Biology Tree) |
| Alexander Morris | grad student | 2023- | Lewis Katz School of Medicine at Temple University (Cell Biology Tree) |
| Emily Pochet | grad student | 2024- | Drexel University College of Medicine, Philadelphia (Cell Biology Tree) |
| Vidhyadhar Nandana | post-doc | 2025- | Fox Chase Cancer Center, Philadelphia (Cell Biology Tree) |
| Soon-keat Ooi | post-doc | 2021-2022 | Fox Chase Cancer Center, Philadelphia (Cell Biology Tree) |
| Musinu Zakari | post-doc | 2022-2024 | Fox Chase Cancer Center, Philadelphia (Cell Biology Tree) |
| Aldana Vistarop | post-doc | 2023-2025 | Fox Chase Cancer Center, Philadelphia (Cell Biology Tree) |
| Baihao Su | research scientist | 2025- | Fox Chase Cancer Center, Philadelphia (Cell Biology Tree) |
Collaborators
Sign in to add collaborator| Grazia Raffa | collaborator | 2020- | Sapienza - Universita di Roma (Cell Biology Tree) |
| Ylli Doksani | collaborator | 2022- | IFOM -FIRC Institute of Molecular Oncology (Cell Biology Tree) |
BETA: Related publications
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Publications
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| Wei S, Tamaki A, Pei J, et al. (2025) NFIB::PHACTR2, a novel atypical fusion gene identified in adenoid cystic carcinoma of the palate. Virchows Archiv : An International Journal of Pathology |
| Hasegawa K, Zhao Y, Garbuzov A, et al. (2024) Clonal inactivation of TERT impairs stem cell competition. Nature |
| Murayama T, Nakayama J, Jiang X, et al. (2024) Targeting DHX9 triggers tumor-intrinsic interferon response and replication stress in Small Cell Lung Cancer. Cancer Discovery |
| Huda A, Arakawa H, Mazzucco G, et al. (2023) The telomerase reverse transcriptase elongates reversed replication forks at telomeric repeats. Science Advances. 9: eadf2011 |
| Chen L, Roake CM, Maccallini P, et al. (2022) TGS1 impacts snRNA 3'-end processing, ameliorates survival motor neuron-dependent neurological phenotypes in vivo and prevents neurodegeneration. Nucleic Acids Research |
| Galati A, Scatolini L, Micheli E, et al. (2021) The S-adenosylmethionine analog sinefungin inhibits the trimethylguanosine synthase TGS1 to promote telomerase activity and telomere lengthening. Febs Letters |
| Chen L, Chang HY, Artandi SE. (2021) Analysis of RNA conformation in endogenously assembled RNPs by icSHAPE. Star Protocols. 2: 100477 |
| Vaidyanathan S, Baik R, Chen L, et al. (2021) Targeted replacement of full-length CFTR in human airway stem cells by CRISPR/Cas9 for pan-mutation correction in the endogenous locus. Molecular Therapy : the Journal of the American Society of Gene Therapy |
| Chen L, Bellone RR, Wang Y, et al. (2020) A novel DDB2 mutation causes defective recognition of UV-induced DNA damages and prevalent equine squamous cell carcinoma. Dna Repair. 97: 103022 |
| Chen L, Roake CM, Galati A, et al. (2020) Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation. Cell Reports. 30: 1358-1372.e5 |