Lu Chen, Ph.D.

Affiliations: 
2021- Fox Chase Cancer Center, Philadelphia 
Area:
telomere and telomerase, RNA biology, cancer and aging
Website:
www.luchenlab.org
Google:
"https://scholar.google.com/citations?user=q7rrWCAAAAAJ&hl=en"
Cross-listing: Cell Biology Tree

Parents

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Joan W. Conaway grad student 2008-2013 University of Kansas Medical Center (Cell Biology Tree)
Steven E. Artandi post-doc 2013-2021 Stanford

Children

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Julia Hoopman grad student 2023- Lewis Katz School of Medicine at Temple University (Cell Biology Tree)
Grigory Matveev grad student 2023- Moscow Institute of Physics and Technology (Cell Biology Tree)
Alexander Morris grad student 2023- Lewis Katz School of Medicine at Temple University (Cell Biology Tree)
Emily Pochet grad student 2024- Drexel University College of Medicine, Philadelphia (Cell Biology Tree)
Vidhyadhar Nandana post-doc 2025- Fox Chase Cancer Center, Philadelphia (Cell Biology Tree)
Soon-keat Ooi post-doc 2021-2022 Fox Chase Cancer Center, Philadelphia (Cell Biology Tree)
Musinu Zakari post-doc 2022-2024 Fox Chase Cancer Center, Philadelphia (Cell Biology Tree)
Aldana Vistarop post-doc 2023-2025 Fox Chase Cancer Center, Philadelphia (Cell Biology Tree)
Baihao Su research scientist 2025- Fox Chase Cancer Center, Philadelphia (Cell Biology Tree)

Collaborators

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Grazia Raffa collaborator 2020- Sapienza - Universita di Roma (Cell Biology Tree)
Ylli Doksani collaborator 2022- IFOM -FIRC Institute of Molecular Oncology (Cell Biology Tree)
BETA: Related publications

Publications

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Wei S, Tamaki A, Pei J, et al. (2025) NFIB::PHACTR2, a novel atypical fusion gene identified in adenoid cystic carcinoma of the palate. Virchows Archiv : An International Journal of Pathology
Hasegawa K, Zhao Y, Garbuzov A, et al. (2024) Clonal inactivation of TERT impairs stem cell competition. Nature
Murayama T, Nakayama J, Jiang X, et al. (2024) Targeting DHX9 triggers tumor-intrinsic interferon response and replication stress in Small Cell Lung Cancer. Cancer Discovery
Huda A, Arakawa H, Mazzucco G, et al. (2023) The telomerase reverse transcriptase elongates reversed replication forks at telomeric repeats. Science Advances. 9: eadf2011
Chen L, Roake CM, Maccallini P, et al. (2022) TGS1 impacts snRNA 3'-end processing, ameliorates survival motor neuron-dependent neurological phenotypes in vivo and prevents neurodegeneration. Nucleic Acids Research
Galati A, Scatolini L, Micheli E, et al. (2021) The S-adenosylmethionine analog sinefungin inhibits the trimethylguanosine synthase TGS1 to promote telomerase activity and telomere lengthening. Febs Letters
Chen L, Chang HY, Artandi SE. (2021) Analysis of RNA conformation in endogenously assembled RNPs by icSHAPE. Star Protocols. 2: 100477
Vaidyanathan S, Baik R, Chen L, et al. (2021) Targeted replacement of full-length CFTR in human airway stem cells by CRISPR/Cas9 for pan-mutation correction in the endogenous locus. Molecular Therapy : the Journal of the American Society of Gene Therapy
Chen L, Bellone RR, Wang Y, et al. (2020) A novel DDB2 mutation causes defective recognition of UV-induced DNA damages and prevalent equine squamous cell carcinoma. Dna Repair. 97: 103022
Chen L, Roake CM, Galati A, et al. (2020) Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation. Cell Reports. 30: 1358-1372.e5
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